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Addison Disease: HELP
Articles from Oxford Radcliffe Trust
Based on 3 articles published since 2009

These are the 3 published articles about Addison Disease that originated from Oxford Radcliffe Trust during 2009-2019.
+ Citations + Abstracts
1 Review Therapy of endocrine disease: Perspectives on the management of adrenal insufficiency: clinical insights from across Europe. 2013

Grossman, Ashley / Johannsson, Gudmundur / Quinkler, Marcus / Zelissen, Pierre. ·Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, Headington, Oxford OX3 7EJ, UK. ·Eur J Endocrinol · Pubmed #24031090.

ABSTRACT: BACKGROUND: Conventional glucocorticoid (GC) replacement for patients with adrenal insufficiency (AI) is inadequate. Patients with AI continue to have increased mortality and morbidity and compromised quality of life despite treatment and monitoring. OBJECTIVES: i) To review current management of AI and the unmet medical need based on literature and treatment experience and ii) to offer practical advice for managing AI in specific clinical situations. METHODS: The review considers the most urgent questions endocrinologists face in managing AI and presents generalised patient cases with suggested strategies for treatment. RESULTS: Optimisation and individualisation of GC replacement remain a challenge because available therapies do not mimic physiological cortisol patterns. While increased mortality and morbidity appear related to inadequate GC replacement, there are no objective measures to guide dose selection and optimisation. Physicians must rely on experience to recognise the clinical signs, which are not unique to AI, of inadequate treatment. The increased demand for corticosteroids during periods of stress can result in a life-threatening adrenal crisis (AC) in a patient with AI. Education is paramount for patients and their caregivers to anticipate, recognise and provide proper early treatment to prevent or reduce the occurrence of ACs. CONCLUSIONS: This review highlights and offers suggestions to address the challenges endocrinologists encounter in treating patients with AI. New preparations are being developed to better mimic normal physiological cortisol levels with convenient, once-daily dosing which may improve treatment outcomes.

2 Review Problem-based review: The patient with acute adrenal failure. 2013

Rogers, Angela / Pillinger, Toby / Wass, John A H. ·Department of Endocrinology, Oxford Centre for Diabetes, Endocrinology and Metabolism, Churchill Hospital, University of Oxford, OX3 7LU. angela_rogers@doctors.org.uk ·Acute Med · Pubmed #23539375.

ABSTRACT: Acute adrenal crisis is an important condition to consider in any shocked patient presenting to the acute medical unit. This article aims to highlight the key aspects of initial management, focussing on the importance of rapid recognition and prompt initiation of steroid treatment.

3 Article Addison's disease. 2009

Baker, Sarah J K / Wass, John A H. ·University of Oxford, Churchill Hospital, Oxford OX2 7LJ UK. ·BMJ · Pubmed #19574314.

ABSTRACT: -- No abstract --