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Alzheimer Disease: HELP
Articles by Sonia Moreno-Grau
Based on 15 articles published since 2010
(Why 15 articles?)
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Between 2010 and 2020, S. Moreno-Grau wrote the following 15 articles about Alzheimer Disease.
 
+ Citations + Abstracts
1 Review Genetic architecture of neurodegenerative dementias. 2020

Clarimon, Jordi / Moreno-Grau, Sonia / Cervera-Carles, Laura / Dols-Icardo, Oriol / Sánchez-Juan, Pascual / Ruiz, Agustín. ·Genetics of Neurodegenerative Disorders Unit, Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; CIBERNED, Center for Networked Biomedical Research into Neurodegenerative Diseases, Madrid, Spain. Electronic address: jclarimon@santpau.cat. · CIBERNED, Center for Networked Biomedical Research into Neurodegenerative Diseases, Madrid, Spain; Research Center and Memory Clinic, Fundació ACE. Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya (UIC), Barcelona, Spain. · Genetics of Neurodegenerative Disorders Unit, Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain; CIBERNED, Center for Networked Biomedical Research into Neurodegenerative Diseases, Madrid, Spain. · CIBERNED, Center for Networked Biomedical Research into Neurodegenerative Diseases, Madrid, Spain; Neurology Service, University Hospital Marqués de Valdecilla (University of Cantabria and IDIVAL), Santander, Spain. ·Neuropharmacology · Pubmed #32097768.

ABSTRACT: Molecular genetics has been an invaluable tool to help understand the molecular basis of neurodegenerative dementias. In this review, we provide an overview of the genetic architecture underlying some of the most prevalent causes of dementia, including Alzheimer's dementia, frontotemporal lobar degeneration, Lewy body dementia, and prion diseases. We also discuss the complexity of the human genome and how the novel technologies have revolutionized and accelerated the way we screen the variety of our DNA. Finally, we also provide some examples about how this genetic knowledge is being transferred into the clinic through personalized medicine. This article is part of the special issue entitled 'The Quest for Disease-Modifying Therapies for Neurodegenerative Disorders'.

2 Review Genome research in pre-dementia stages of Alzheimer's disease. 2016

Moreno-Grau, Sonia / Ruiz, Agustín. ·Memory Clinic of Fundació ACE,Institut Català de Neurociències Aplicades,Barcelona,Spain. ·Expert Rev Mol Med · Pubmed #27237222.

ABSTRACT: Genetic characterization of individuals at risk of Alzheimer's disease (AD), i.e. people having amyloid deposits in the brain without symptoms, people suffering from subjective cognitive decline (SCD) or mild cognitive impairment (MCI), has spurred the interests of researchers. However, their pre-dementia genetic profile remains mostly unexplored. In this study, we reviewed the loci related to phenotypes of AD, MCI and SCD from literature and performed the first meta-analyses evaluating the role of apolipoprotein E (APOE) in the risk of conversion from a healthy status to MCI and SCD. For AD dementia risk, an increased number of loci have been identified; to date, 28 genes have been associated with Late Onset AD. In MCI syndrome, APOE is confirmed as a pheno-conversion factor leading from MCI to AD, and clusterin is a promising candidate. Additionally, our meta-analyses revealed APOE as genetic risk factor to convert from a healthy status to MCI [OR = 1.849 (1.587-2.153); P = 2.80  × 10-15] and to a lesser extent from healthy status to SCD [OR = 1.151 (1.015-1.304); P = 0.028]. Thus, we believe that genetic studies in longitudinal SCD and MCI series may provide new therapeutic targets and improve the existing knowledge of AD. This type of studies must be completed on healthy subjects to better understand the natural disease resistance to brain insults and neurodegeneration.

3 Article Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer's disease and three causality networks: The GR@ACE project. 2019

Moreno-Grau, Sonia / de Rojas, Itziar / Hernández, Isabel / Quintela, Inés / Montrreal, Laura / Alegret, Montserrat / Hernández-Olasagarre, Begoña / Madrid, Laura / González-Perez, Antonio / Maroñas, Olalla / Rosende-Roca, Maitée / Mauleón, Ana / Vargas, Liliana / Lafuente, Asunción / Abdelnour, Carla / Rodríguez-Gómez, Octavio / Gil, Silvia / Santos-Santos, Miguel Ángel / Espinosa, Ana / Ortega, Gemma / Sanabria, Ángela / Pérez-Cordón, Alba / Cañabate, Pilar / Moreno, Mariola / Preckler, Silvia / Ruiz, Susana / Aguilera, Nuria / Pineda, Juan Antonio / Macías, Juan / Alarcón-Martín, Emilio / Sotolongo-Grau, Oscar / Anonymous4911119 / Anonymous4921119 / Anonymous4931119 / Marquié, Marta / Monté-Rubio, Gemma / Valero, Sergi / Benaque, Alba / Clarimón, Jordi / Bullido, Maria Jesus / García-Ribas, Guillermo / Pástor, Pau / Sánchez-Juan, Pascual / Álvarez, Victoria / Piñol-Ripoll, Gerard / García-Alberca, Jose Maria / Royo, José Luis / Franco, Emilio / Mir, Pablo / Calero, Miguel / Medina, Miguel / Rábano, Alberto / Ávila, Jesús / Antúnez, Carmen / Real, Luis Miguel / Orellana, Adelina / Carracedo, Ángel / Sáez, María Eugenia / Tárraga, Lluís / Boada, Mercè / Ruiz, Agustín. ·Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain. · Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain. · Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela, Santiago de Compostela, Spain. · CAEBI, Centro Andaluz de Estudios Bioinformáticos, Sevilla, Spain. · Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, Spain. · Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain; Department of Surgery, Biochemistry and Molecular Biology, School of Medicine, University of Málaga, Málaga, Spain. · CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain; Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Universitat Autònoma de Barcelona, Barcelona, Spain. · CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain; Centro de Biologia Molecular Severo Ochoa (C.S.I.C.-U.A.M.), Universidad Autonoma de Madrid, Madrid, Spain; Instituto de Investigacion Sanitaria "Hospital la Paz" (IdIPaz), Madrid, Spain. · Hospital Universitario Ramón y Cajal, Madrid, Spain. · Fundació per la Recerca Biomèdica i Social Mútua Terrassa, and Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, University of Barcelona School of Medicine, Terrassa, Spain. · CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain; Neurology Service 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain. · Laboratorio de Genética Hospital Universitario Central de Asturias, Oviedo, Spain; Instituto de Investigación Biosanitaria del Principado de Asturias (ISPA), Oviedo, Spain. · CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain; Unitat Trastorns Cognitius, Hospital Universitari Santa Maria de Lleida, Institut de Recerca Biomédica de Lleida (IRBLLeida), Lleida, Spain. · Alzheimer Research Center & Memory Clinic, Andalusian Institute for Neuroscience, Málaga, Spain. · Department of Surgery, Biochemistry and Molecular Biology, School of Medicine, University of Málaga, Málaga, Spain. · Unidad de Demencias, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. · CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología. Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain. · CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain; CIEN Foundation, Queen Sofia Foundation Alzheimer Center, Madrid, Spain; Instituto de Salud Carlos III (ISCIII), Madrid, Spain. · CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain; CIEN Foundation, Queen Sofia Foundation Alzheimer Center, Madrid, Spain. · CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain; CIEN Foundation, Queen Sofia Foundation Alzheimer Center, Madrid, Spain; BT-CIEN, Madrid, Spain. · CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain; Department of Molecular Neuropathology, Centro de Biología Molecular "Severo Ochoa" (CBMSO), Consejo Superior de Investigaciones Científicas (CSIC)/Universidad Autónoma de Madrid (UAM), Madrid, Spain. · Unidad de Demencias, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, Spain. · Unidad Clínica de Enfermedades Infecciosas y Microbiología. Hospital Universitario de Valme, Sevilla, Spain; Department of Surgery, Biochemistry and Molecular Biology, School of Medicine, University of Málaga, Málaga, Spain. · Grupo de Medicina Xenómica, Centro Nacional de Genotipado (CEGEN-PRB3-ISCIII). Universidade de Santiago de Compostela, Santiago de Compostela, Spain; Fundación Pública Galega de Medicina Xenómica- CIBERER-IDIS, Santiago de Compostela, Spain. · Research Center and Memory clinic Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain; CIBERNED, Network Center for Biomedical Research in Neurodegenerative Diseases, National Institute of Health Carlos III, Madrid, Spain. Electronic address: aruiz@fundacioace.org. ·Alzheimers Dement · Pubmed #31473137.

ABSTRACT: INTRODUCTION: Large variability among Alzheimer's disease (AD) cases might impact genetic discoveries and complicate dissection of underlying biological pathways. METHODS: Genome Research at Fundacio ACE (GR@ACE) is a genome-wide study of dementia and its clinical endophenotypes, defined based on AD's clinical certainty and vascular burden. We assessed the impact of known AD loci across endophenotypes to generate loci categories. We incorporated gene coexpression data and conducted pathway analysis per category. Finally, to evaluate the effect of heterogeneity in genetic studies, GR@ACE series were meta-analyzed with additional genome-wide association study data sets. RESULTS: We classified known AD loci into three categories, which might reflect the disease clinical heterogeneity. Vascular processes were only detected as a causal mechanism in probable AD. The meta-analysis strategy revealed the ANKRD31-rs4704171 and NDUFAF6-rs10098778 and confirmed SCIMP-rs7225151 and CD33-rs3865444. DISCUSSION: The regulation of vasculature is a prominent causal component of probable AD. GR@ACE meta-analysis revealed novel AD genetic signals, strongly driven by the presence of clinical heterogeneity in the AD series.

4 Article A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity. 2019

van der Lee, Sven J / Conway, Olivia J / Jansen, Iris / Carrasquillo, Minerva M / Kleineidam, Luca / van den Akker, Erik / Hernández, Isabel / van Eijk, Kristel R / Stringa, Najada / Chen, Jason A / Zettergren, Anna / Andlauer, Till F M / Diez-Fairen, Monica / Simon-Sanchez, Javier / Lleó, Alberto / Zetterberg, Henrik / Nygaard, Marianne / Blauwendraat, Cornelis / Savage, Jeanne E / Mengel-From, Jonas / Moreno-Grau, Sonia / Wagner, Michael / Fortea, Juan / Keogh, Michael J / Blennow, Kaj / Skoog, Ingmar / Friese, Manuel A / Pletnikova, Olga / Zulaica, Miren / Lage, Carmen / de Rojas, Itziar / Riedel-Heller, Steffi / Illán-Gala, Ignacio / Wei, Wei / Jeune, Bernard / Orellana, Adelina / Then Bergh, Florian / Wang, Xue / Hulsman, Marc / Beker, Nina / Tesi, Niccolo / Morris, Christopher M / Indakoetxea, Begoña / Collij, Lyduine E / Scherer, Martin / Morenas-Rodríguez, Estrella / Ironside, James W / van Berckel, Bart N M / Alcolea, Daniel / Wiendl, Heinz / Strickland, Samantha L / Pastor, Pau / Rodríguez Rodríguez, Eloy / Anonymous1381184 / Anonymous1391184 / Anonymous1401184 / Anonymous1411184 / Anonymous1421184 / Anonymous1431184 / Boeve, Bradley F / Petersen, Ronald C / Ferman, Tanis J / van Gerpen, Jay A / Reinders, Marcel J T / Uitti, Ryan J / Tárraga, Lluís / Maier, Wolfgang / Dols-Icardo, Oriol / Kawalia, Amit / Dalmasso, Maria Carolina / Boada, Mercè / Zettl, Uwe K / van Schoor, Natasja M / Beekman, Marian / Allen, Mariet / Masliah, Eliezer / de Munain, Adolfo López / Pantelyat, Alexander / Wszolek, Zbigniew K / Ross, Owen A / Dickson, Dennis W / Graff-Radford, Neill R / Knopman, David / Rademakers, Rosa / Lemstra, Afina W / Pijnenburg, Yolande A L / Scheltens, Philip / Gasser, Thomas / Chinnery, Patrick F / Hemmer, Bernhard / Huisman, Martijn A / Troncoso, Juan / Moreno, Fermin / Nohr, Ellen A / Sørensen, Thorkild I A / Heutink, Peter / Sánchez-Juan, Pascual / Posthuma, Danielle / Anonymous1441184 / Clarimón, Jordi / Christensen, Kaare / Ertekin-Taner, Nilüfer / Scholz, Sonja W / Ramirez, Alfredo / Ruiz, Agustín / Slagboom, Eline / van der Flier, Wiesje M / Holstege, Henne. ·Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. s.j.vanderlee@amsterdamumc.nl. · Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. s.j.vanderlee@amsterdamumc.nl. · Department of Neuroscience, Mayo Clinic Florida, Jacksonville, FL, 32224, USA. · Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. · Department of Complex Trait Genetics, Center for Neurogenomics and Cognitive Research, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. · Department for Neurodegenerative Diseases and Geriatric Psychiatry, University of Bonn, Bonn, Germany. · DZNE, German Center for Neurodegenerative Diseases, Bonn, Germany. · Division of Neurogenetics and Molecular Psychiatry, Department of Psychiatry and Psychotherapy, Faculty of Medicine, University Hospital Cologne, Cologne, Germany. · Molecular Epidemiology, Leiden University Medical Center, Leiden, The Netherlands. · Pattern Recognition and Bioinformatics, Delft University of Technology, Delft, The Netherlands. · Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain. · Centro de Investigacion Biomedica en Red en Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain. · Department of Neurology, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands. · Amsterdam UMC-Vrije Universiteit Amsterdam, Department of Epidemiology and Biostatistics, Amsterdam Public Health Research Institute, Amsterdam, The Netherlands. · Interdepartmental Program in Bioinformatics, University of California, Los Angeles, USA. · Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AgeCap) at the University of Gothenburg, Gothenburg, Sweden. · Max Planck Institute of Psychiatry, Munich, Germany. · Department of Neurology, Klinikum rechts der Isar, Technical University of Munich, Munich, Germany. · German Competence Network Multiple Sclerosis (KKNMS), Munich, Germany. · Movement Disorders and Memory Unit, Department of Neurology, University Hospital Mutua de Terrassa, Barcelona, Spain. · Fundacio per la Recerca Biomedica I Social Mutua Terrassa, Terrassa, Barcelona, Spain. · German Center for Neurodegenerative Diseases (DZNE)-Tübingen, Tübingen, Germany. · Hertie Institute for Clinical Brain Research, University of Tübingen, Tübingen, Germany. · Memory Unit, Department of Neurology, IIB Sant Pau, Hospital de la Santa Creu i Sant Pau, Universitat Autonoma de Barcelona, Barcelona, Spain. · Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden. · Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden. · Department of Molecular Neuroscience, UCL Institute of Neurology, Queen Square, London, UK. · The Danish Aging Research Center, Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark. · Neurodegenerative Diseases Research Unit, National Institute of Neurological Disorders and Stroke, Bethesda, MD, 20892-3707, USA. · Epidemiology, Biostatistics and Biodemography, Department of Public Health, University of Southern Denmark, Odense, Denmark. · Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, NE1 3BZ, UK. · Department of Clinical Neurosciences, University of Cambridge, Cambridge, CB2 0QQ, UK. · Institut für Neuroimmunologie und Multiple Sklerose (INIMS), Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany. · Department of Pathology (Neuropathology), Johns Hopkins University Medical Center, Baltimore, MD, USA. · Instituto Biodonostia, San Sebastian, Spain. · University Hospital "Marques de Valdecilla", Santander, Spain. · IDIVAL, Santander, Spain. · Institute of Social Medicine, Occupational Health and Public Health (ISAP), University of Leipzig, Leipzig, Germany. · Department of Neurology, University of Leipzig, Leipzig, Germany. · Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. · Newcastle Brain Tissue Resource, Edwardson Building, Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, NE4 5PL, UK. · Cognitive Disorders Unit, Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain. · Department of Radiology and Nuclear Medicine, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. · Department of Primary Medical Care, Center for Psychosocial Medicine, University Medical Center, Hamburg-Eppendorf, Germany. · Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, EH4 2XU, UK. · Department of Neurology, Klinik für Neurologie mit Institut für Translationale Neurologie, University of Münster, Münster, Germany. · Department of Neurology, Mayo Clinic Minnesota, Rochester, MN, 55905, USA. · Department of Psychiatry and Psychology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA. · Department of Neurology, Mayo Clinic Florida, Jacksonville, FL, 32224, USA. · Delft Bioinformatics Lab, Delft University of Technology, Delft, The Netherlands. · Fundación Instituto Leloir-IIBBA-CONICET, Buenos Aires, Argentina. · Department of Neurology, University of Rostock, Rostock, Germany. · Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. · Department of Neurology, Hospital Universitario San Sebastian, San Sebastian, Spain. · Department of Neurology, Johns Hopkins University Medical Center, Baltimore, MD, 21287, USA. · Center of Neurology, Department of Neurodegenerative diseases, Hertie-Institute for Clinical Brain Research, University of Tuebingen, Tuebingen, Germany. · MRC Mitochondrial Biology Unit, University of Cambridge, Cambridge, CB2 0QQ, UK. · Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. · Department of Sociology, VU University, Amsterdam, The Netherlands. · Research Unit of Gynecology and Obstetrics, Department of Clinical Research, University of Southern Denmark, Odense, Denmark. · Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Copenhagen, Denmark. · Department of Public Health, Section of Epidemiology, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. · MRC Integrative Epidemiology Unit, Bristol University, Bristol, UK. · Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark. · Department of Clinical Genetics, Odense University Hospital, Odense, Denmark. · Dutch Society for Research on Ageing, Leiden, The Netherlands. · Alzheimer Center Amsterdam, Department of Neurology, Amsterdam Neuroscience, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. h.holstege@amsterdamumc.nl. · Department of Clinical Genetics, Vrije Universiteit Amsterdam, Amsterdam UMC, Amsterdam, The Netherlands. h.holstege@amsterdamumc.nl. ·Acta Neuropathol · Pubmed #31131421.

ABSTRACT: The genetic variant rs72824905-G (minor allele) in the PLCG2 gene was previously associated with a reduced Alzheimer's disease risk (AD). The role of PLCG2 in immune system signaling suggests it may also protect against other neurodegenerative diseases and possibly associates with longevity. We studied the effect of the rs72824905-G on seven neurodegenerative diseases and longevity, using 53,627 patients, 3,516 long-lived individuals and 149,290 study-matched controls. We replicated the association of rs72824905-G with reduced AD risk and we found an association with reduced risk of dementia with Lewy bodies (DLB) and frontotemporal dementia (FTD). We did not find evidence for an effect on Parkinson's disease (PD), amyotrophic lateral sclerosis (ALS) and multiple sclerosis (MS) risks, despite adequate sample sizes. Conversely, the rs72824905-G allele was associated with increased likelihood of longevity. By-proxy analyses in the UK Biobank supported the associations with both dementia and longevity. Concluding, rs72824905-G has a protective effect against multiple neurodegenerative diseases indicating shared aspects of disease etiology. Our findings merit studying the PLCγ2 pathway as drug-target.

5 Article Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates Aβ, tau, immunity and lipid processing. 2019

Kunkle, Brian W / Grenier-Boley, Benjamin / Sims, Rebecca / Bis, Joshua C / Damotte, Vincent / Naj, Adam C / Boland, Anne / Vronskaya, Maria / van der Lee, Sven J / Amlie-Wolf, Alexandre / Bellenguez, Céline / Frizatti, Aura / Chouraki, Vincent / Martin, Eden R / Sleegers, Kristel / Badarinarayan, Nandini / Jakobsdottir, Johanna / Hamilton-Nelson, Kara L / Moreno-Grau, Sonia / Olaso, Robert / Raybould, Rachel / Chen, Yuning / Kuzma, Amanda B / Hiltunen, Mikko / Morgan, Taniesha / Ahmad, Shahzad / Vardarajan, Badri N / Epelbaum, Jacques / Hoffmann, Per / Boada, Merce / Beecham, Gary W / Garnier, Jean-Guillaume / Harold, Denise / Fitzpatrick, Annette L / Valladares, Otto / Moutet, Marie-Laure / Gerrish, Amy / Smith, Albert V / Qu, Liming / Bacq, Delphine / Denning, Nicola / Jian, Xueqiu / Zhao, Yi / Del Zompo, Maria / Fox, Nick C / Choi, Seung-Hoan / Mateo, Ignacio / Hughes, Joseph T / Adams, Hieab H / Malamon, John / Sanchez-Garcia, Florentino / Patel, Yogen / Brody, Jennifer A / Dombroski, Beth A / Naranjo, Maria Candida Deniz / Daniilidou, Makrina / Eiriksdottir, Gudny / Mukherjee, Shubhabrata / Wallon, David / Uphill, James / Aspelund, Thor / Cantwell, Laura B / Garzia, Fabienne / Galimberti, Daniela / Hofer, Edith / Butkiewicz, Mariusz / Fin, Bertrand / Scarpini, Elio / Sarnowski, Chloe / Bush, Will S / Meslage, Stéphane / Kornhuber, Johannes / White, Charles C / Song, Yuenjoo / Barber, Robert C / Engelborghs, Sebastiaan / Sordon, Sabrina / Voijnovic, Dina / Adams, Perrie M / Vandenberghe, Rik / Mayhaus, Manuel / Cupples, L Adrienne / Albert, Marilyn S / De Deyn, Peter P / Gu, Wei / Himali, Jayanadra J / Beekly, Duane / Squassina, Alessio / Hartmann, Annette M / Orellana, Adelina / Blacker, Deborah / Rodriguez-Rodriguez, Eloy / Lovestone, Simon / Garcia, Melissa E / Doody, Rachelle S / Munoz-Fernadez, Carmen / Sussams, Rebecca / Lin, Honghuang / Fairchild, Thomas J / Benito, Yolanda A / Holmes, Clive / Karamujić-Čomić, Hata / Frosch, Matthew P / Thonberg, Hakan / Maier, Wolfgang / Roshchupkin, Gennady / Ghetti, Bernardino / Giedraitis, Vilmantas / Kawalia, Amit / Li, Shuo / Huebinger, Ryan M / Kilander, Lena / Moebus, Susanne / Hernández, Isabel / Kamboh, M Ilyas / Brundin, RoseMarie / Turton, James / Yang, Qiong / Katz, Mindy J / Concari, Letizia / Lord, Jenny / Beiser, Alexa S / Keene, C Dirk / Helisalmi, Seppo / Kloszewska, Iwona / Kukull, Walter A / Koivisto, Anne Maria / Lynch, Aoibhinn / Tarraga, Lluís / Larson, Eric B / Haapasalo, Annakaisa / Lawlor, Brian / Mosley, Thomas H / Lipton, Richard B / Solfrizzi, Vincenzo / Gill, Michael / Longstreth, W T / Montine, Thomas J / Frisardi, Vincenza / Diez-Fairen, Monica / Rivadeneira, Fernando / Petersen, Ronald C / Deramecourt, Vincent / Alvarez, Ignacio / Salani, Francesca / Ciaramella, Antonio / Boerwinkle, Eric / Reiman, Eric M / Fievet, Nathalie / Rotter, Jerome I / Reisch, Joan S / Hanon, Olivier / Cupidi, Chiara / Andre Uitterlinden, A G / Royall, Donald R / Dufouil, Carole / Maletta, Raffaele Giovanni / de Rojas, Itziar / Sano, Mary / Brice, Alexis / Cecchetti, Roberta / George-Hyslop, Peter St / Ritchie, Karen / Tsolaki, Magda / Tsuang, Debby W / Dubois, Bruno / Craig, David / Wu, Chuang-Kuo / Soininen, Hilkka / Avramidou, Despoina / Albin, Roger L / Fratiglioni, Laura / Germanou, Antonia / Apostolova, Liana G / Keller, Lina / Koutroumani, Maria / Arnold, Steven E / Panza, Francesco / Gkatzima, Olymbia / Asthana, Sanjay / Hannequin, Didier / Whitehead, Patrice / Atwood, Craig S / Caffarra, Paolo / Hampel, Harald / Quintela, Inés / Carracedo, Ángel / Lannfelt, Lars / Rubinsztein, David C / Barnes, Lisa L / Pasquier, Florence / Frölich, Lutz / Barral, Sandra / McGuinness, Bernadette / Beach, Thomas G / Johnston, Janet A / Becker, James T / Passmore, Peter / Bigio, Eileen H / Schott, Jonathan M / Bird, Thomas D / Warren, Jason D / Boeve, Bradley F / Lupton, Michelle K / Bowen, James D / Proitsi, Petra / Boxer, Adam / Powell, John F / Burke, James R / Kauwe, John S K / Burns, Jeffrey M / Mancuso, Michelangelo / Buxbaum, Joseph D / Bonuccelli, Ubaldo / Cairns, Nigel J / McQuillin, Andrew / Cao, Chuanhai / Livingston, Gill / Carlson, Chris S / Bass, Nicholas J / Carlsson, Cynthia M / Hardy, John / Carney, Regina M / Bras, Jose / Carrasquillo, Minerva M / Guerreiro, Rita / Allen, Mariet / Chui, Helena C / Fisher, Elizabeth / Masullo, Carlo / Crocco, Elizabeth A / DeCarli, Charles / Bisceglio, Gina / Dick, Malcolm / Ma, Li / Duara, Ranjan / Graff-Radford, Neill R / Evans, Denis A / Hodges, Angela / Faber, Kelley M / Scherer, Martin / Fallon, Kenneth B / Riemenschneider, Matthias / Fardo, David W / Heun, Reinhard / Farlow, Martin R / Kölsch, Heike / Ferris, Steven / Leber, Markus / Foroud, Tatiana M / Heuser, Isabella / Galasko, Douglas R / Giegling, Ina / Gearing, Marla / Hüll, Michael / Geschwind, Daniel H / Gilbert, John R / Morris, John / Green, Robert C / Mayo, Kevin / Growdon, John H / Feulner, Thomas / Hamilton, Ronald L / Harrell, Lindy E / Drichel, Dmitriy / Honig, Lawrence S / Cushion, Thomas D / Huentelman, Matthew J / Hollingworth, Paul / Hulette, Christine M / Hyman, Bradley T / Marshall, Rachel / Jarvik, Gail P / Meggy, Alun / Abner, Erin / Menzies, Georgina E / Jin, Lee-Way / Leonenko, Ganna / Real, Luis M / Jun, Gyungah R / Baldwin, Clinton T / Grozeva, Detelina / Karydas, Anna / Russo, Giancarlo / Kaye, Jeffrey A / Kim, Ronald / Jessen, Frank / Kowall, Neil W / Vellas, Bruno / Kramer, Joel H / Vardy, Emma / LaFerla, Frank M / Jöckel, Karl-Heinz / Lah, James J / Dichgans, Martin / Leverenz, James B / Mann, David / Levey, Allan I / Pickering-Brown, Stuart / Lieberman, Andrew P / Klopp, Norman / Lunetta, Kathryn L / Wichmann, H-Erich / Lyketsos, Constantine G / Morgan, Kevin / Marson, Daniel C / Brown, Kristelle / Martiniuk, Frank / Medway, Christopher / Mash, Deborah C / Nöthen, Markus M / Masliah, Eliezer / Hooper, Nigel M / McCormick, Wayne C / Daniele, Antonio / McCurry, Susan M / Bayer, Anthony / McDavid, Andrew N / Gallacher, John / McKee, Ann C / van den Bussche, Hendrik / Mesulam, Marsel / Brayne, Carol / Miller, Bruce L / Riedel-Heller, Steffi / Miller, Carol A / Miller, Joshua W / Al-Chalabi, Ammar / Morris, John C / Shaw, Christopher E / Myers, Amanda J / Wiltfang, Jens / O'Bryant, Sid / Olichney, John M / Alvarez, Victoria / Parisi, Joseph E / Singleton, Andrew B / Paulson, Henry L / Collinge, John / Perry, William R / Mead, Simon / Peskind, Elaine / Cribbs, David H / Rossor, Martin / Pierce, Aimee / Ryan, Natalie S / Poon, Wayne W / Nacmias, Benedetta / Potter, Huntington / Sorbi, Sandro / Quinn, Joseph F / Sacchinelli, Eleonora / Raj, Ashok / Spalletta, Gianfranco / Raskind, Murray / Caltagirone, Carlo / Bossù, Paola / Orfei, Maria Donata / Reisberg, Barry / Clarke, Robert / Reitz, Christiane / Smith, A David / Ringman, John M / Warden, Donald / Roberson, Erik D / Wilcock, Gordon / Rogaeva, Ekaterina / Bruni, Amalia Cecilia / Rosen, Howard J / Gallo, Maura / Rosenberg, Roger N / Ben-Shlomo, Yoav / Sager, Mark A / Mecocci, Patrizia / Saykin, Andrew J / Pastor, Pau / Cuccaro, Michael L / Vance, Jeffery M / Schneider, Julie A / Schneider, Lori S / Slifer, Susan / Seeley, William W / Smith, Amanda G / Sonnen, Joshua A / Spina, Salvatore / Stern, Robert A / Swerdlow, Russell H / Tang, Mitchell / Tanzi, Rudolph E / Trojanowski, John Q / Troncoso, Juan C / Van Deerlin, Vivianna M / Van Eldik, Linda J / Vinters, Harry V / Vonsattel, Jean Paul / Weintraub, Sandra / Welsh-Bohmer, Kathleen A / Wilhelmsen, Kirk C / Williamson, Jennifer / Wingo, Thomas S / Woltjer, Randall L / Wright, Clinton B / Yu, Chang-En / Yu, Lei / Saba, Yasaman / Pilotto, Alberto / Bullido, Maria J / Peters, Oliver / Crane, Paul K / Bennett, David / Bosco, Paola / Coto, Eliecer / Boccardi, Virginia / De Jager, Phil L / Lleo, Alberto / Warner, Nick / Lopez, Oscar L / Ingelsson, Martin / Deloukas, Panagiotis / Cruchaga, Carlos / Graff, Caroline / Gwilliam, Rhian / Fornage, Myriam / Goate, Alison M / Sanchez-Juan, Pascual / Kehoe, Patrick G / Amin, Najaf / Ertekin-Taner, Nilifur / Berr, Claudine / Debette, Stéphanie / Love, Seth / Launer, Lenore J / Younkin, Steven G / Dartigues, Jean-Francois / Corcoran, Chris / Ikram, M Arfan / Dickson, Dennis W / Nicolas, Gael / Campion, Dominique / Tschanz, JoAnn / Schmidt, Helena / Hakonarson, Hakon / Clarimon, Jordi / Munger, Ron / Schmidt, Reinhold / Farrer, Lindsay A / Van Broeckhoven, Christine / C O'Donovan, Michael / DeStefano, Anita L / Jones, Lesley / Haines, Jonathan L / Deleuze, Jean-Francois / Owen, Michael J / Gudnason, Vilmundur / Mayeux, Richard / Escott-Price, Valentina / Psaty, Bruce M / Ramirez, Alfredo / Wang, Li-San / Ruiz, Agustin / van Duijn, Cornelia M / Holmans, Peter A / Seshadri, Sudha / Williams, Julie / Amouyel, Phillippe / Schellenberg, Gerard D / Lambert, Jean-Charles / Pericak-Vance, Margaret A / Anonymous1811199 / Anonymous1821199 / Anonymous1831199 / Anonymous1841199 / and others. ·John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. bkunkle@miami.edu. · Inserm, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. · Institut Pasteur de Lille, Lille, France. · Univ. Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. · Division of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. · UK Dementia Research Institute at Cardiff, Cardiff University, Cardiff, UK. · Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. · Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. · Centre National de Recherche en Génomique Humaine, Institut de Biologie François Jacob, CEA, Université Paris-Saclay, and LabEx GENMED, Evry, France. · Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. · Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. · Framingham Heart Study, Framingham, MA, USA. · Department of Neurology, Boston University School of Medicine, Boston, MA, USA. · John P. Hussman Institute for Human Genomics, University of Miami Miller School of Medicine, Miami, FL, USA. · Neurodegenerative Brain Diseases Group, Center for Molecular Neurology, VIB, Antwerp, Belgium. · Laboratory for Neurogenetics, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. · Icelandic Heart Association, Kopavogur, Iceland. · Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades-Universitat Internacional de Catalunya, Barcelona, Spain. · Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas, Instituto de Salud Carlos III, Madrid, Spain. · Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. · Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. · Department of Neurology, Kuopio University Hospital, Kuopio, Finland. · Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, NY, USA. · Gertrude H. Sergievsky Center, Columbia University, New York, NY, USA. · Department of Neurology, Columbia University, New York, NY, USA. · UMR 894, Center for Psychiatry and Neuroscience, Inserm, Université Paris Descartes, Paris, France. · Institute of Human Genetics, University of Bonn, Bonn, Germany. · Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. · Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland. · School of Biotechnology, Dublin City University, Dublin, Ireland. · Department of Family Medicine, University of Washington, Seattle, WA, USA. · Department of Epidemiology, University of Washington, Seattle, WA, USA. · Dementia Research Centre, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. · Department of Biostatistics, University of Michigan, Ann Arbor, MI, USA. · Faculty of Medicine, University of Iceland, Reykjavik, Iceland. · Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, TX, USA. · Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. · UK Dementia Research Institute at UCL, Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK. · Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IDIVAL), Santander, Spain. · Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. · Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain. · Department of Neurology, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece. · Department of Medicine, University of Washington, Seattle, WA, USA. · Normandie University, UNIROUEN, Inserm U1245, and Rouen University Hospital, Department of Neurology, Department of Genetics and CNR-MAJ, Normandy Center for Genomic and Personalized Medicine, Rouen, France. · Department of Neurodegenerative Disease, MRC Prion Unit at UCL, Institute of Prion Diseases, London, UK. · Centre for Public Health, University of Iceland, Reykjavik, Iceland. · Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico, Neurodegenerative Diseases Unit, Milan, Italy. · University of Milan, Centro Dino Ferrari, Milan, Italy. · Clinical Division of Neurogeriatrics, Department of Neurology, Medical University Graz, Graz, Austria. · Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria. · Institute for Computational Biology, Department of Population & Quantitative Health Sciences, Case Western Reserve University, Cleveland, OH, USA. · Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany. · Program in Medical and Population Genetics, Broad Institute, Cambridge, MA, USA. · Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, TX, USA. · Laboratory for Neurochemistry and Behavior, Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. · Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium. · Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany. · Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX, USA. · Laboratory for Cognitive Neurology, Department of Neurology, University Hospital and University of Leuven, Leuven, Belgium. · Department of Neurology, Johns Hopkins University, Baltimore, MD, USA. · National Alzheimer's Coordinating Center, University of Washington, Seattle, WA, USA. · Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany. · Department of Epidemiology, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, USA. · Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, MA, USA. · Department of Psychiatry, University of Oxford, Oxford, UK. · Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, MD, USA. · Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, TX, USA. · Division of Clinical Neurosciences, School of Medicine, University of Southampton, Southampton, UK. · Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, MA, USA. · Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, TX, USA. · C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, MA, USA. · Theme Aging, Unit for Hereditary Dementias, Karolinska University Hospital-Solna, Stockholm, Sweden. · Karolinska Institutet, Department of Neurobiology, Care Sciences and Society, Alzheimer Research Center, Division of Neurogeriatrics, Solna, Sweden. · German Center for Neurodegenerative Diseases, Bonn, Germany. · Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. · Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN, USA. · Department of Public Health and Caring Sciences/Geriatrics, Uppsala University, Uppsala, Sweden. · Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany. · Department of Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA. · Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany. · Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. · Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. · Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, PA, USA. · Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK. · Department of Neurology, Albert Einstein College of Medicine, Bronx, NY, USA. · Section of Neuroscience, DIMEC-University of Parma, Parma, Italy. · FERB-Alzheimer Center, Gazzaniga (Bergamo), Italy. · Department of Pathology, University of Washington, Seattle, WA, USA. · Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland. · Mercer's Institute for Research on Aging, St. James's Hospital and Trinity College, Dublin, Ireland. · St. James's Hospital and Trinity College, Dublin, Ireland. · Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. · A.I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. · Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, MS, USA. · Interdisciplinary Department of Medicine, Geriatric Medicine and Memory Unity, University of Bari, Bari, Italy. · Department of Neurology, University of Washington, Seattle, WA, USA. · Department of Geriatrics, Center for Aging Brain, University of Bari, Bari, Italy. · Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain. · Memory Disorders Unit, Department of Neurology, Hospital Universitari Mutua de Terrassa, Terrassa, Barcelona, Spain. · Department of Internal Medicine, Erasmus University Medical Center, Rotterdamt, the Netherlands. · Netherlands Consortium on Health Aging and National Genomics Initiative, Leiden, the Netherlands. · Department of Neurology, Mayo Clinic, Rochester, MN, USA. · CHU Lille, Memory Center of Lille (Centre Mémoire de Ressources et de Recherche), Lille, France. · Department of Clinical and Behavioral Neurology, Experimental Neuropsychobiology Laboratory, IRCCS Santa Lucia Foundation, Rome, Italy. · School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, TX, USA. · Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX, USA. · Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ, USA. · Arizona Alzheimer's Consortium, Phoenix, AZ, USA. · Banner Alzheimer's Institute, Phoenix, AZ, USA. · Department of Psychiatry, University of Arizona, Phoenix, AZ, USA. · Institute for Translational Genomics and Population Sciences, Departments of Pediatrics and Medicine, Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. · Department of Clinical Sciences, University of Texas Southwestern Medical Center, Dallas, TX, USA. · University Paris Descartes, EA 4468, AP-HP, Geriatrics Department, Hôpital Broca, Paris, France. · Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy. · Departments of Psychiatry, Medicine, Family & Community Medicine, South Texas Veterans Health Administration Geriatric Research Education & Clinical Center (GRECC), UT Health Science Center at San Antonio, San Antonio, TX, USA. · University of Bordeaux, Inserm 1219, Bordeaux, France. · Department of Neurology, Bordeaux University Hospital / CHU de Bordeaux, Bordeaux, France. · Department of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA. · Inserm U1127, CNRS UMR 7225, Sorbonne Universités, UPMC Université Paris 06, UMRS 1127, Institut du Cerveau et de la Moelle Épinière, Paris, France. · AP-HP, Department of Genetics, Pitié-Salpêtrière Hospital, Paris, France. · Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. · Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK. · Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada. · Inserm U1061 Neuropsychiatry, La Colombière Hospital, Montpellier, France. · Montpellier University, Montpellier, France. · Department of Clinical Brain Sciences, University of Edinburgh, Edinburgh, UK. · VA Puget Sound Health Care System/>GRECC, Seattle, WA, USA. · Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, WA, USA. · Institut de la Mémoire et de la Maladie d'Alzheimer and Institut du Cerveau et de la Moelle Épinière, Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France. · Institut des Neurosciences Translationnelles de Paris, Institut du Cerveau et de la Moelle Épinière, Paris, France. · Inserm, CNRS, UMR-S975, Institut du Cerveau et de la Moelle Epinière, Paris, France. · Sorbonne Universités, Université Pierre et Marie Curie, Hôpital de la Pitié-Salpêtrière, AP-HP, Paris, France. · Ageing Group, Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK. · Departments of Neurology, Pharmacology & Neuroscience, Texas Tech University Health Science Center, Lubbock, TX, USA. · Department of Neurology, University of Michigan, Ann Arbor, MI, USA. · Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, MI, USA. · Michigan Alzheimer Disease Center, Ann Arbor, MI, USA. · Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden. · Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, IN, USA. · Department of Medical and Molecular Genetics, Indiana University, Indianapolis, IN, USA. · Department of Neurology, Indiana University, Indianapolis, IN, USA. · Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, IN, USA. · Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA. · Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, WI, USA. · Department of Medicine, University of Wisconsin, Madison, WI, USA. · Wisconsin Alzheimer's Disease Research Center, Madison, WI, USA. · AXA Research Fund & Sorbonne University Chair, Paris, France. · Sorbonne University, GRC n° 21, Alzheimer Precision Medicine (APM), AP-HP, Pitié-Salpêtrière Hospital, Paris, France. · Brain & Spine Institute, Inserm U 1127, CNRS UMR 7225, Paris, France. · Institute of Memory and Alzheimer's Disease, Department of Neurology, Pitié-Salpêtrière Hospital, AP-HP, Paris, France. · Grupo de Medicina Xenomica, Universidade de Santiago de Compostela, Centro Nacional de Genotipado, Centro de Investigación Biomédica en Red de Enfermedades Raras, Santiago de Compostela, Spain. · UK Dementia Research Institute, University of Cambridge, Cambridge, UK. · Department of Neurological Sciences, Rush University Medical Center, Chicago, IL, USA. · Department of Behavioral Sciences, Rush University Medical Center, Chicago, IL, USA. · Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. · Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Heidelberg, Germany. · Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, AZ, USA. · Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. · Department of Psychology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA. · Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. (and more) ·Nat Genet · Pubmed #30820047.

ABSTRACT: Risk for late-onset Alzheimer's disease (LOAD), the most prevalent dementia, is partially driven by genetics. To identify LOAD risk loci, we performed a large genome-wide association meta-analysis of clinically diagnosed LOAD (94,437 individuals). We confirm 20 previous LOAD risk loci and identify five new genome-wide loci (IQCK, ACE, ADAM10, ADAMTS1, and WWOX), two of which (ADAM10, ACE) were identified in a recent genome-wide association (GWAS)-by-familial-proxy of Alzheimer's or dementia. Fine-mapping of the human leukocyte antigen (HLA) region confirms the neurological and immune-mediated disease haplotype HLA-DR15 as a risk factor for LOAD. Pathway analysis implicates immunity, lipid metabolism, tau binding proteins, and amyloid precursor protein (APP) metabolism, showing that genetic variants affecting APP and Aβ processing are associated not only with early-onset autosomal dominant Alzheimer's disease but also with LOAD. Analyses of risk genes and pathways show enrichment for rare variants (P = 1.32 × 10

6 Article Correlations between plasma and PET beta-amyloid levels in individuals with subjective cognitive decline: the Fundació ACE Healthy Brain Initiative (FACEHBI). 2018

de Rojas, Itziar / Romero, J / Rodríguez-Gomez, O / Pesini, P / Sanabria, A / Pérez-Cordon, A / Abdelnour, C / Hernández, I / Rosende-Roca, M / Mauleón, A / Vargas, L / Alegret, M / Espinosa, A / Ortega, G / Gil, S / Guitart, M / Gailhajanet, A / Santos-Santos, M A / Moreno-Grau, Sonia / Sotolongo-Grau, O / Ruiz, S / Montrreal, L / Martín, E / Pelejà, E / Lomeña, F / Campos, F / Vivas, A / Gómez-Chiari, M / Tejero, M A / Giménez, J / Pérez-Grijalba, V / Marquié, G M / Monté-Rubio, G / Valero, S / Orellana, A / Tárraga, L / Sarasa, M / Ruiz, A / Boada, M / Anonymous390971. ·Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya-Barcelona, C/ Marquès de Sentmenat, 57, 08029, Barcelona, Spain. · Araclon Biotech©, Zaragoza, Spain. · Servei de Medicina Nuclear, Hospital Clínic i Provincial, Barcelona, Spain. · Departament de Diagnòstic per la Imatge, Clínica Corachan, Barcelona, Spain. · Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya-Barcelona, C/ Marquès de Sentmenat, 57, 08029, Barcelona, Spain. aruiz@fundacioace.org. ·Alzheimers Res Ther · Pubmed #30497535.

ABSTRACT: BACKGROUND: Peripheral biomarkers that identify individuals at risk of developing Alzheimer's disease (AD) or predicting high amyloid beta (Aβ) brain burden would be highly valuable. To facilitate clinical trials of disease-modifying therapies, plasma concentrations of Aβ species are good candidates for peripheral AD biomarkers, but studies to date have generated conflicting results. METHODS: The Fundació ACE Healthy Brain Initiative (FACEHBI) study uses a convenience sample of 200 individuals diagnosed with subjective cognitive decline (SCD) at the Fundació ACE (Barcelona, Spain) who underwent amyloid florbetaben( RESULTS: FBB-PET global SUVR correlated weakly but significantly with Aβ42/40 plasma ratios. For TP42/40, this observation persisted after controlling for age and APOE ε4 allele carrier status (R CONCLUSION: Brain and plasma Aβ levels are partially correlated in individuals diagnosed with SCD. Aβ plasma measurements, particularly the TP42/40 ratio, could generate a new recruitment strategy independent of the APOE genotype that would improve identification of SCD subjects with brain amyloidosis and reduce the rate of screening failures in preclinical AD studies. Independent replication of these findings is warranted.

7 Article Exploring Genetic Associations of Alzheimer's Disease Loci With Mild Cognitive Impairment Neurocognitive Endophenotypes. 2018

Espinosa, Ana / Hernández-Olasagarre, Begoña / Moreno-Grau, Sonia / Kleineidam, Luca / Heilmann-Heimbach, Stefanie / Hernández, Isabel / Wolfsgruber, Steffen / Wagner, Holger / Rosende-Roca, Maitée / Mauleón, Ana / Vargas, Liliana / Lafuente, Asunción / Rodríguez-Gómez, Octavio / Abdelnour, Carla / Gil, Silvia / Marquié, Marta / Santos-Santos, Miguel A / Sanabria, Ángela / Ortega, Gemma / Monté-Rubio, Gemma / Pérez, Alba / Ibarria, Marta / Ruiz, Susana / Kornhuber, Johannes / Peters, Oliver / Frölich, Lutz / Hüll, Michael / Wiltfang, Jens / Luck, Tobias / Riedel-Heller, Steffi / Montrreal, Laura / Cañabate, Pilar / Moreno, Mariola / Preckler, Silvia / Aguilera, Nuria / de Rojas, Itziar / Orellana, Adelina / Alegret, Montserrat / Valero, Sergi / Nöthen, Markus M / Wagner, Michael / Jessen, Frank / Tárraga, Lluis / Boada, Mercè / Ramírez, Alfredo / Ruiz, Agustín. ·Research Center and Memory Clinic, Fundació ACE, Institut Català de Neurociències Aplicades, Universitat Internacional de Catalunya, Barcelona, Spain. · Department for Neurodegenerative Diseases and Geriatric Psychiatry, University Hospital Bonn, Bonn, Germany. · German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. · Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. · Institute of Human Genetics, University of Bonn, School of Medicine and University Hospital Bonn, Bonn, Germany. · Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. · Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. · Department of Psychiatry and Psychotherapy, University Clinic Erlangen, Erlangen, Germany. · Department of Psychiatry, Charité University Medicine, Berlin, Germany. · Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. · Center for Geriatric Medicine and Section of Gerontopsychiatry and Neuropsychology, Medical School, University of Freiburg, Freiburg, Germany. · Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany. · Department of Economic and Social Sciences & Institute of Social Medicine, Rehabilitation Sciences and Healthcare Research (ISRV), University of Applied Sciences Nordhausen, Nordhausen, Germany. · Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany. ·Front Aging Neurosci · Pubmed #30425636.

ABSTRACT: The role of genetic risk markers for Alzheimer's disease (AD) in mediating the neurocognitive endophenotypes (NEs) of subjects with mild cognitive impairment (MCI) has rarely been studied. The aim of the present study was to investigate the relationship between well-known AD-associated single-nucleotide polymorphisms (SNPs) and individual NEs routinely evaluated during diagnosis of MCI, AD, and other dementias. The Fundació ACE (ACE) dataset, comprising information from 1245 patients with MCI, was analyzed, including the total sample, amnestic MCI (aMCI) (

8 Article Usefulness of peripapillary nerve fiber layer thickness assessed by optical coherence tomography as a biomarker for Alzheimer's disease. 2018

Sánchez, Domingo / Castilla-Marti, Miguel / Rodríguez-Gómez, Octavio / Valero, Sergi / Piferrer, Albert / Martínez, Gabriel / Martínez, Joan / Serra, Judit / Moreno-Grau, Sonia / Hernández-Olasagarre, Begoña / De Rojas, Itziar / Hernández, Isabel / Abdelnour, Carla / Rosende-Roca, Maitée / Vargas, Liliana / Mauleón, Ana / Santos-Santos, Miguel A / Alegret, Montserrat / Ortega, Gemma / Espinosa, Ana / Pérez-Cordón, Alba / Sanabria, Ángela / Ciudin, Andrea / Simó, Rafael / Hernández, Cristina / Villoslada, Pablo / Ruiz, Agustín / Tàrraga, Lluís / Boada, Mercè. ·Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain. dsanchez@fundacioace.com. · Clínica Oftalmológica Dr. Castilla, Barcelona, Spain. · Valles Ophthalmology Research, Hospital General de Catalunya, Sant Cugat del Vallès, Spain. · Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain. · Psychiatry Department, Hospital Universitari Vall d'Hebron, CIBERSAM, Universitat Autònoma de Barcelona, Barcelona, Spain. · Topcon España Clinical Affairs, Sant Just Desvern, Spain. · Faculty of Medicine and Dentistry. Faculty of Medicine and Dentistry, Universidad de Antofagasta, Antofagasta, Chile. · Iberoamerican Cochrane Centre, Barcelona, Spain. · Diabetes and Metabolism Research Unit and Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólica Asociada (CIBERDEM), Vall d'Hebron Research Institute, Barcelona, Spain. · Institut d'Investigacions Biomèdiques August Pi Sunyer (IDIBAPS), Barcelona, Spain. ·Sci Rep · Pubmed #30397251.

ABSTRACT: The use of optical coherence tomography (OCT) has been suggested as a potential biomarker for Alzheimer's Disease based on previously reported thinning of the retinal nerve fiber layer (RNFL) in Alzheimer's disease's (AD) and Mild Cognitive Impairment (MCI). However, other studies have not shown such results. 930 individuals (414 cognitively healthy individuals, 192 probable amnestic MCI and 324 probable AD) attending a memory clinic were consecutively included and underwent spectral domain OCT (Maestro, Topcon) examinations to assess differences in peripapillary RNFL thickness, using a design of high ecological validity. Adjustment by age, education, sex and OCT image quality was performed. We found a non-significant decrease in mean RNFL thickness as follows: control group: 100,20 ± 14,60 µm, MCI group: 98,54 ± 14,43 µm and AD group: 96,61 ± 15,27 µm. The multivariate adjusted analysis revealed no significant differences in mean overall (p = 0.352), temporal (p = 0,119), nasal (p = 0,151), superior (p = 0,435) or inferior (p = 0,825) quadrants between AD, MCI and control groups. These results do not support the usefulness of peripapillary RNFL analysis as a marker of cognitive impairment or in discriminating between cognitive groups. The analysis of other OCT measurements in other retinal areas and layers as biomarkers for AD should be tested further.

9 Article Genome-wide significant risk factors on chromosome 19 and the 2018

Moreno-Grau, Sonia / Hernández, Isabel / Heilmann-Heimbach, Stefanie / Ruiz, Susana / Rosende-Roca, Maitée / Mauleón, Ana / Vargas, Liliana / Rodríguez-Gómez, Octavio / Alegret, Montserrat / Espinosa, Ana / Ortega, Gemma / Aguilera, Nuria / Abdelnour, Carla / Neuroimaging Initiative, Alzheimer's Disease / Gil, Silvia / Maier, Wolfgang / Sotolongo-Grau, Oscar / Tárraga, Lluís / Ramirez, Alfredo / López-Arrrieta, Jesús / Antúnez, Carmen / Serrano-Ríos, Manuel / Boada, Mercè / Ruiz, Agustín. ·Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Univesitat Internacional de Catalunya, Barcelona, Spain. · Institute of Human Genetics, University of Bonn, Bonn, Germany. · Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany. · Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. · German Center for Neurodegenerative Diseases, DZNE, Bonn, Germany. · Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. · Memory Unit, University Hospital La Paz-Cantoblanco, Madrid, Spain. · Dementia Unit, University Hospital Virgen de la Arrixaca, Murcia, Spain. · Centro de Investigación Biomédica en Red de Diabetes y Enfermedades Metabólicas Asociadas, CIBERDEM, Spain, Hospital Clínico San Carlos, Madrid, Spain. ·Oncotarget · Pubmed #29872490.

ABSTRACT: The apolipoprotein E (

10 Article Exploring APOE genotype effects on Alzheimer's disease risk and amyloid β burden in individuals with subjective cognitive decline: The FundacioACE Healthy Brain Initiative (FACEHBI) study baseline results. 2018

Moreno-Grau, Sonia / Rodríguez-Gómez, Octavio / Sanabria, Ángela / Pérez-Cordón, Alba / Sánchez-Ruiz, Domingo / Abdelnour, Carla / Valero, Sergi / Hernández, Isabel / Rosende-Roca, Maitée / Mauleón, Ana / Vargas, Liliana / Lafuente, Asunción / Gil, Silvia / Santos-Santos, Miguel Ángel / Alegret, Montserrat / Espinosa, Ana / Ortega, Gemma / Guitart, Marina / Gailhajanet, Anna / de Rojas, Itziar / Sotolongo-Grau, Óscar / Ruiz, Susana / Aguilera, Nuria / Papasey, Judith / Martín, Elvira / Peleja, Esther / Anonymous4090927 / Lomeña, Francisco / Campos, Francisco / Vivas, Assumpta / Gómez-Chiari, Marta / Tejero, Miguel Ángel / Giménez, Joan / Serrano-Ríos, Manuel / Orellana, Adelina / Tárraga, Lluís / Ruiz, Agustín / Boada, Mercè / Anonymous4100927. ·Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain. · Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain; Department of Psychiatry, Hospital Universitari Vall d'Hebron, CIBERSAM, Universitat Autònoma de Barcelona, Barcelona, Spain. · Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain; Cognition and brain plasticity group [Bellvitge Biomedical Research Institute-IDIBELL], L'Hospitalet de Llobregat, Barcelona, Spain. · Servei de Medicina Nuclear, Hospital Clínic i Provincial, Barcelona, Spain. · Departament de Diagnòstic per la Imatge, Clínica Corachan, Barcelona, Spain. · CIBERDEM-Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders, Madrid, Spain; Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), Madrid, Spain. · Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain. Electronic address: aruiz@fundacioace.com. ·Alzheimers Dement · Pubmed #29156223.

ABSTRACT: INTRODUCTION: Subjective cognitive decline (SCD) has been proposed as a potential preclinical stage of Alzheimer's disease (AD). Nevertheless, the genetic and biomarker profiles of SCD individuals remain mostly unexplored. METHODS: We evaluated apolipoprotein E (APOE) ε4's effect in the risk of presenting SCD, using the Fundacio ACE Healthy Brain Initiative (FACEHBI) SCD cohort and Spanish controls, and performed a meta-analysis addressing the same question. We assessed the relationship between APOE dosage and brain amyloid burden in the FACEHBI SCD and Alzheimer's Disease Neuroimaging Initiative cohorts. RESULTS: Analysis of the FACEHBI cohort and the meta-analysis demonstrated SCD individuals presented higher allelic frequencies of APOE ε4 with respect to controls. APOE dosage explained 9% (FACEHBI cohort) and 11% (FACEHBI and Alzheimer's Disease Neuroimaging Initiative cohorts) of the variance of cerebral amyloid levels. DISCUSSION: The FACEHBI sample presents APOE ε4 enrichment, suggesting that a pool of AD patients is nested in our sample. Cerebral amyloid levels are partially explained by the APOE allele dosage, suggesting that other genetic or epigenetic factors are involved in this AD endophenotype.

11 Article Genetic risk for schizophrenia and psychosis in Alzheimer disease. 2018

DeMichele-Sweet, M A A / Weamer, E A / Klei, L / Vrana, D T / Hollingshead, D J / Seltman, H J / Sims, R / Foroud, T / Hernandez, I / Moreno-Grau, S / Tárraga, L / Boada, M / Ruiz, A / Williams, J / Mayeux, R / Lopez, O L / Sibille, E L / Kamboh, M I / Devlin, B / Sweet, R A. ·Department of Psychiatry, University of Pittsburgh, Pittsburgh, PA, USA. · Department of Neurology, University of Pittsburgh, Pittsburgh, PA, USA. · Department of Computational Biology, Carnegie Mellon University, Pittsburgh, PA, USA. · Genomics Research Core of the Health Sciences Core Research Facilities, University of Pittsburgh, Pittsburgh, PA, USA. · Department of Statistics, Carnegie Mellon University, Pittsburgh, PA, USA. · Division of Psychological Medicine and Clinical Neuroscience, School of Medicine, Cardiff University, Cardiff, UK. · Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA. · Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain. · Departments of Neurology, Psychiatry and Epidemiology, Columbia University, New York, NY, USA. · Department of Psychiatry and Pharmacology and Toxicology, University of Toronto, Toronto, ON, Canada. · Campbell Family Mental Health Research Institute of CAMH, Toronto, ON, Canada. · Department of Human Genetics, University of Pittsburgh, Pittsburgh, PA, USA. · VISN 4 Mental Illness Research, Education and Clinical Center (MIRECC), VA Pittsburgh Healthcare System, Pittsburgh, PA, USA. ·Mol Psychiatry · Pubmed #28461698.

ABSTRACT: Psychotic symptoms, defined as the occurrence of delusions or hallucinations, are frequent in Alzheimer disease (AD), affecting ~40 to 60% of individuals with AD (AD with psychosis (AD+P)). In comparison with AD subjects without psychosis, AD+P subjects have more rapid cognitive decline and poor outcomes. Prior studies have estimated the heritability of psychosis in AD at 61%, but the underlying genetic sources of this risk are not known. We evaluated a Discovery Cohort of 2876 AD subjects with (N=1761) or without psychosis (N=1115). All subjects were genotyped using a custom genotyping array designed to evaluate single-nucleotide polymorphisms (SNPs) with evidence of genetic association with AD+P and include SNPs affecting or putatively affecting risk for schizophrenia and AD. Results were replicated in an independent cohort of 2194 AD subjects with (N=734) or without psychosis (N=1460). We found that AD+P is associated with polygenic risk for a set of novel loci and inversely associated with polygenic risk for schizophrenia. Among the biologic pathways identified by the associations of schizophrenia SNPs with AD+P are endosomal trafficking, autophagy and calcium channel signaling. To the best of our knowledge, these findings provide the first clear demonstration that AD+P is associated with common genetic variation. In addition, they provide an unbiased link between polygenic risk for schizophrenia and a lower risk of psychosis in AD. This provides an opportunity to leverage progress made in identifying the biologic effects of schizophrenia alleles to identify novel mechanisms protecting against more rapid cognitive decline and psychosis risk in AD.

12 Article Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. 2017

Sims, Rebecca / van der Lee, Sven J / Naj, Adam C / Bellenguez, Céline / Badarinarayan, Nandini / Jakobsdottir, Johanna / Kunkle, Brian W / Boland, Anne / Raybould, Rachel / Bis, Joshua C / Martin, Eden R / Grenier-Boley, Benjamin / Heilmann-Heimbach, Stefanie / Chouraki, Vincent / Kuzma, Amanda B / Sleegers, Kristel / Vronskaya, Maria / Ruiz, Agustin / Graham, Robert R / Olaso, Robert / Hoffmann, Per / Grove, Megan L / Vardarajan, Badri N / Hiltunen, Mikko / Nöthen, Markus M / White, Charles C / Hamilton-Nelson, Kara L / Epelbaum, Jacques / Maier, Wolfgang / Choi, Seung-Hoan / Beecham, Gary W / Dulary, Cécile / Herms, Stefan / Smith, Albert V / Funk, Cory C / Derbois, Céline / Forstner, Andreas J / Ahmad, Shahzad / Li, Hongdong / Bacq, Delphine / Harold, Denise / Satizabal, Claudia L / Valladares, Otto / Squassina, Alessio / Thomas, Rhodri / Brody, Jennifer A / Qu, Liming / Sánchez-Juan, Pascual / Morgan, Taniesha / Wolters, Frank J / Zhao, Yi / Garcia, Florentino Sanchez / Denning, Nicola / Fornage, Myriam / Malamon, John / Naranjo, Maria Candida Deniz / Majounie, Elisa / Mosley, Thomas H / Dombroski, Beth / Wallon, David / Lupton, Michelle K / Dupuis, Josée / Whitehead, Patrice / Fratiglioni, Laura / Medway, Christopher / Jian, Xueqiu / Mukherjee, Shubhabrata / Keller, Lina / Brown, Kristelle / Lin, Honghuang / Cantwell, Laura B / Panza, Francesco / McGuinness, Bernadette / Moreno-Grau, Sonia / Burgess, Jeremy D / Solfrizzi, Vincenzo / Proitsi, Petra / Adams, Hieab H / Allen, Mariet / Seripa, Davide / Pastor, Pau / Cupples, L Adrienne / Price, Nathan D / Hannequin, Didier / Frank-García, Ana / Levy, Daniel / Chakrabarty, Paramita / Caffarra, Paolo / Giegling, Ina / Beiser, Alexa S / Giedraitis, Vilmantas / Hampel, Harald / Garcia, Melissa E / Wang, Xue / Lannfelt, Lars / Mecocci, Patrizia / Eiriksdottir, Gudny / Crane, Paul K / Pasquier, Florence / Boccardi, Virginia / Henández, Isabel / Barber, Robert C / Scherer, Martin / Tarraga, Lluis / Adams, Perrie M / Leber, Markus / Chen, Yuning / Albert, Marilyn S / Riedel-Heller, Steffi / Emilsson, Valur / Beekly, Duane / Braae, Anne / Schmidt, Reinhold / Blacker, Deborah / Masullo, Carlo / Schmidt, Helena / Doody, Rachelle S / Spalletta, Gianfranco / Longstreth, W T / Fairchild, Thomas J / Bossù, Paola / Lopez, Oscar L / Frosch, Matthew P / Sacchinelli, Eleonora / Ghetti, Bernardino / Yang, Qiong / Huebinger, Ryan M / Jessen, Frank / Li, Shuo / Kamboh, M Ilyas / Morris, John / Sotolongo-Grau, Oscar / Katz, Mindy J / Corcoran, Chris / Dunstan, Melanie / Braddel, Amy / Thomas, Charlene / Meggy, Alun / Marshall, Rachel / Gerrish, Amy / Chapman, Jade / Aguilar, Miquel / Taylor, Sarah / Hill, Matt / Fairén, Mònica Díez / Hodges, Angela / Vellas, Bruno / Soininen, Hilkka / Kloszewska, Iwona / Daniilidou, Makrina / Uphill, James / Patel, Yogen / Hughes, Joseph T / Lord, Jenny / Turton, James / Hartmann, Annette M / Cecchetti, Roberta / Fenoglio, Chiara / Serpente, Maria / Arcaro, Marina / Caltagirone, Carlo / Orfei, Maria Donata / Ciaramella, Antonio / Pichler, Sabrina / Mayhaus, Manuel / Gu, Wei / Lleó, Alberto / Fortea, Juan / Blesa, Rafael / Barber, Imelda S / Brookes, Keeley / Cupidi, Chiara / Maletta, Raffaele Giovanni / Carrell, David / Sorbi, Sandro / Moebus, Susanne / Urbano, Maria / Pilotto, Alberto / Kornhuber, Johannes / Bosco, Paolo / Todd, Stephen / Craig, David / Johnston, Janet / Gill, Michael / Lawlor, Brian / Lynch, Aoibhinn / Fox, Nick C / Hardy, John / Anonymous10931124 / Albin, Roger L / Apostolova, Liana G / Arnold, Steven E / Asthana, Sanjay / Atwood, Craig S / Baldwin, Clinton T / Barnes, Lisa L / Barral, Sandra / Beach, Thomas G / Becker, James T / Bigio, Eileen H / Bird, Thomas D / Boeve, Bradley F / Bowen, James D / Boxer, Adam / Burke, James R / Burns, Jeffrey M / Buxbaum, Joseph D / Cairns, Nigel J / Cao, Chuanhai / Carlson, Chris S / Carlsson, Cynthia M / Carney, Regina M / Carrasquillo, Minerva M / Carroll, Steven L / Diaz, Carolina Ceballos / Chui, Helena C / Clark, David G / Cribbs, David H / Crocco, Elizabeth A / DeCarli, Charles / Dick, Malcolm / Duara, Ranjan / Evans, Denis A / Faber, Kelley M / Fallon, Kenneth B / Fardo, David W / Farlow, Martin R / Ferris, Steven / Foroud, Tatiana M / Galasko, Douglas R / Gearing, Marla / Geschwind, Daniel H / Gilbert, John R / Graff-Radford, Neill R / Green, Robert C / Growdon, John H / Hamilton, Ronald L / Harrell, Lindy E / Honig, Lawrence S / Huentelman, Matthew J / Hulette, Christine M / Hyman, Bradley T / Jarvik, Gail P / Abner, Erin / Jin, Lee-Way / Jun, Gyungah / Karydas, Anna / Kaye, Jeffrey A / Kim, Ronald / Kowall, Neil W / Kramer, Joel H / LaFerla, Frank M / Lah, James J / Leverenz, James B / Levey, Allan I / Li, Ge / Lieberman, Andrew P / Lunetta, Kathryn L / Lyketsos, Constantine G / Marson, Daniel C / Martiniuk, Frank / Mash, Deborah C / Masliah, Eliezer / McCormick, Wayne C / McCurry, Susan M / McDavid, Andrew N / McKee, Ann C / Mesulam, Marsel / Miller, Bruce L / Miller, Carol A / Miller, Joshua W / Morris, John C / Murrell, Jill R / Myers, Amanda J / O'Bryant, Sid / Olichney, John M / Pankratz, Vernon S / Parisi, Joseph E / Paulson, Henry L / Perry, William / Peskind, Elaine / Pierce, Aimee / Poon, Wayne W / Potter, Huntington / Quinn, Joseph F / Raj, Ashok / Raskind, Murray / Reisberg, Barry / Reitz, Christiane / Ringman, John M / Roberson, Erik D / Rogaeva, Ekaterina / Rosen, Howard J / Rosenberg, Roger N / Sager, Mark A / Saykin, Andrew J / Schneider, Julie A / Schneider, Lon S / Seeley, William W / Smith, Amanda G / Sonnen, Joshua A / Spina, Salvatore / Stern, Robert A / Swerdlow, Russell H / Tanzi, Rudolph E / Thornton-Wells, Tricia A / Trojanowski, John Q / Troncoso, Juan C / Van Deerlin, Vivianna M / Van Eldik, Linda J / Vinters, Harry V / Vonsattel, Jean Paul / Weintraub, Sandra / Welsh-Bohmer, Kathleen A / Wilhelmsen, Kirk C / Williamson, Jennifer / Wingo, Thomas S / Woltjer, Randall L / Wright, Clinton B / Yu, Chang-En / Yu, Lei / Garzia, Fabienne / Golamaully, Feroze / Septier, Gislain / Engelborghs, Sebastien / Vandenberghe, Rik / De Deyn, Peter P / Fernadez, Carmen Muñoz / Benito, Yoland Aladro / Thonberg, Hakan / Forsell, Charlotte / Lilius, Lena / Kinhult-Stählbom, Anne / Kilander, Lena / Brundin, RoseMarie / Concari, Letizia / Helisalmi, Seppo / Koivisto, Anne Maria / Haapasalo, Annakaisa / Dermecourt, Vincent / Fievet, Nathalie / Hanon, Olivier / Dufouil, Carole / Brice, Alexis / Ritchie, Karen / Dubois, Bruno / Himali, Jayanadra J / Keene, C Dirk / Tschanz, JoAnn / Fitzpatrick, Annette L / Kukull, Walter A / Norton, Maria / Aspelund, Thor / Larson, Eric B / Munger, Ron / Rotter, Jerome I / Lipton, Richard B / Bullido, María J / Hofman, Albert / Montine, Thomas J / Coto, Eliecer / Boerwinkle, Eric / Petersen, Ronald C / Alvarez, Victoria / Rivadeneira, Fernando / Reiman, Eric M / Gallo, Maura / O'Donnell, Christopher J / Reisch, Joan S / Bruni, Amalia Cecilia / Royall, Donald R / Dichgans, Martin / Sano, Mary / Galimberti, Daniela / St George-Hyslop, Peter / Scarpini, Elio / Tsuang, Debby W / Mancuso, Michelangelo / Bonuccelli, Ubaldo / Winslow, Ashley R / Daniele, Antonio / Wu, Chuang-Kuo / Anonymous10941124 / Peters, Oliver / Nacmias, Benedetta / Riemenschneider, Matthias / Heun, Reinhard / Brayne, Carol / Rubinsztein, David C / Bras, Jose / Guerreiro, Rita / Al-Chalabi, Ammar / Shaw, Christopher E / Collinge, John / Mann, David / Tsolaki, Magda / Clarimón, Jordi / Sussams, Rebecca / Lovestone, Simon / O'Donovan, Michael C / Owen, Michael J / Behrens, Timothy W / Mead, Simon / Goate, Alison M / Uitterlinden, Andre G / Holmes, Clive / Cruchaga, Carlos / Ingelsson, Martin / Bennett, David A / Powell, John / Golde, Todd E / Graff, Caroline / De Jager, Philip L / Morgan, Kevin / Ertekin-Taner, Nilufer / Combarros, Onofre / Psaty, Bruce M / Passmore, Peter / Younkin, Steven G / Berr, Claudine / Gudnason, Vilmundur / Rujescu, Dan / Dickson, Dennis W / Dartigues, Jean-François / DeStefano, Anita L / Ortega-Cubero, Sara / Hakonarson, Hakon / Campion, Dominique / Boada, Merce / Kauwe, John Keoni / Farrer, Lindsay A / Van Broeckhoven, Christine / Ikram, M Arfan / Jones, Lesley / Haines, Jonathan L / Tzourio, Christophe / Launer, Lenore J / Escott-Price, Valentina / Mayeux, Richard / Deleuze, Jean-François / Amin, Najaf / Holmans, Peter A / Pericak-Vance, Margaret A / Amouyel, Philippe / van Duijn, Cornelia M / Ramirez, Alfredo / Wang, Li-San / Lambert, Jean-Charles / Seshadri, Sudha / Williams, Julie / Schellenberg, Gerard D / and others. ·Institute of Psychological Medicine and Clinical Neurosciences, MRC Centre for Neuropsychiatric Genetics and Genomics, Cardiff University, Cardiff, UK. · Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. · Department of Biostatistics and Epidemiology/Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. · INSERM, U1167, RID-AGE-Risk Factors and Molecular Determinants of Aging-Related Diseases, Lille, France. · Institut Pasteur de Lille, Lille, France. · University Lille, U1167-Excellence Laboratory LabEx DISTALZ, Lille, France. · Icelandic Heart Association, Kopavogur, Iceland. · John P. Hussman Institute for Human Genomics, University of Miami, Miami, Florida, USA. · CEA/Institut de Génomique, Centre National de Génotypage, Evry, France. · Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, Washington, USA. · Dr. John T. Macdonald Foundation, Department of Human Genetics, University of Miami, Miami, Florida, USA. · Institute of Human Genetics, University of Bonn, Bonn, Germany. · Department of Genomics, Life &Brain Center, University of Bonn, Bonn, Germany. · Boston University School of Medicine, Boston, Massachusetts, USA. · Framingham Heart Study, Framingham, Massachusetts, USA. · Penn Neurodegeneration Genomics Center, Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. · Neurodegenerative Brain Diseases Group, Department of Molecular Genetics, VIB, Antwerp, Belgium. · Institute Born-Bunge, University of Antwerp, Antwerp, Belgium. · Research Center and Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain. · Immunology Biomarkers Group, Genentech, South San Francisco, California, USA. · Division of Medical Genetics, University Hospital and Department of Biomedicine, University of Basel, Basel, Switzerland. · School of Public Health, Human Genetics Center, University of Texas Health Science Center at Houston, Houston, Texas, USA. · Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Neurology, Columbia University, New York, New York, USA. · Gertrude H. Sergievsky Center, Columbia University, New York, New York, USA. · Department of Neurology, Columbia University, New York, New York, USA. · Institute of Biomedicine, University of Eastern Finland, Kuopio, Finland. · Department of Neurology, Kuopio University Hospital, Kuopio, Finland. · Program in Translational NeuroPsychiatric Genomics, Institute for the Neurosciences, Departments of Neurology and Psychiatry, Brigham and Women's Hospital, Boston, Massachusetts, USA. · UMR 894, Center for Psychiatry and Neuroscience, INSERM, Université Paris Descartes, Paris, France. · German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. · Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. · Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. · Faculty of Medicine, University of Iceland, Reykjavik, Iceland. · Institute for Systems Biology, Seattle, Washington, USA. · School of Biotechnology, Dublin City University, Dublin, Ireland. · Section of Neuroscience and Clinical Pharmacology, Department of Biomedical Sciences, University of Cagliari, Cagliari, Italy. · Neurology Service and CIBERNED, 'Marqués de Valdecilla' University Hospital (University of Cantabria and IFIMAV), Santander, Spain. · Department of Immunology, Hospital Universitario Doctor Negrín, Las Palmas de Gran Canaria, Spain. · Brown Foundation Institute of Molecular Medicine, University of Texas Health Sciences Center at Houston, Houston, Texas, USA. · Departments of Medicine, Geriatrics, Gerontology and Neurology, University of Mississippi Medical Center, Jackson, Mississippi, USA. · Centre Hospitalier du Rouvray, Sotteville les Rouen, France. · INSERM U1079, Rouen University, IRIB, Normandy University, Rouen, France. · Department of Basic and Clinical Neuroscience, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. · Genetic Epidemiology, QIMR Berghofer Medical Research Institute, Herston, Queensland, Australia. · Department of Geriatric Medicine, Karolinska University Hospital Huddinge, Stockholm, Sweden. · Aging Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet and Stockholm University, Stockholm, Sweden. · Institute of Genetics, Queen's Medical Centre, University of Nottingham, Nottingham, UK. · Department of Medicine, University of Washington, Seattle, Washington, USA. · Section of Computational Biomedicine, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA. · Neurodegenerative Disease Unit, Department of Basic Medicine, Neuroscience, and Sense Organs, University of Bari Aldo Moro, Bari, Italy. · Centre for Public Health, School of Medicine, Dentistry and Biomedical Sciences, Queen's University, Belfast, UK. · Department of Neuroscience, Mayo Clinic, Jacksonville, Florida, USA. · Geriatric Medicine-Memory Unit and Rare Disease Centre, University of Bari Aldo Moro, Bari, Italy. · Geriatric Unit and Gerontology-Geriatrics Research Laboratory, Department of Medical Sciences, IRCCS Casa Sollievo della Sofferenza, San Giovanni Rotondo, Italy. · Section of Gerontology and Geriatrics, Department of Medicine, University of Perugia, Perugia, Italy. · Department of Neurology, Rouen University Hospital, Rouen, France. · Department of Neurology, University Hospital La Paz, Universidad Autónoma de Madrid, Madrid, Spain. · Instituto de Investigación Sanitaria Hospital la Paz (IdiPAZ), Madrid, Spain. · Centro de Investigación Biomédica en Red de Enfermedades Neurodegenerativas (CIBERNED), Instituto de Salud Carlos III, Madrid, Spain. · National Heart, Lung, and Blood Institute, Bethesda, Maryland, USA. · Center for Translational Research in Neurodegenerative Disease, Department of Neuroscience, University of Florida, Gainesville, Florida, USA. · Department of Neuroscience, University of Parma, Parma, Italy. · Center for Cognitive Disorders AUSL, Parma, Italy. · Department of Psychiatry, Martin Luther University Halle-Wittenberg, Halle, Germany. · Department of Public Health/Geriatrics, Uppsala University, Uppsala, Sweden. · AXA Research Fund and UPMC Chair, Paris, France. · Sorbonne Universités, Université Pierre et Marie Curie, Paris, France. · Institut de la Mémoire et de la Maladie d'Alzheimer (IM2A) and Institut du Cerveau et de la Moelle Épinière (ICM), Département de Neurologie, Hôpital de la Pitié-Salpêtrière, Paris, France. · Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Bethesda, Maryland, USA. · Centre Hospitalier Universitaire de Lille, Epidemiology and Public Health Department, Lille, France. · INSERM UMRS 1171, CNR-Maj, Lille, France. · Department of Pharmacology and Neuroscience, University of North Texas Health Science Center, Fort Worth, Texas, USA. · Department of Primary Medical Care, University Medical Centre Hamburg-Eppendorf, Hamburg, Germany. · Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA. · Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany. · Department of Neurology, Johns Hopkins University, Baltimore, Maryland, USA. · Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany. · Faculty of Pharmaceutical Sciences, University of Iceland, Reykjavik, Iceland. · National Alzheimer's Coordinating Center, University of Washington, Seattle, Washington, USA. · Schools of Life Sciences and Medicine, University of Nottingham, Nottingham, UK. · Department of Neurology, Clinical Division of Neurogeriatrics, Medical University Graz, Graz, Austria. · Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA. · Department of Psychiatry, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA. · Department of Neurology, Catholic University of Rome, Rome, Italy. · Institute of Molecular Biology and Biochemistry, Medical University Graz, Graz, Austria. · Alzheimer's Disease and Memory Disorders Center, Baylor College of Medicine, Houston, Texas, USA. · Experimental Neuropsychiatry Laboratory, IRCCS Santa Lucia Foundation, Department of Clinical and Behavioural Neurology, Rome, Italy. · Department of Neurology, University of Washington, Seattle, Washington, USA. · Department of Epidemiology, University of Washington, Seattle, Washington, USA. · Office of Strategy and Measurement, University of North Texas Health Science Center, Fort Worth, Texas, USA. · Department of Psychiatry, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. · Department of Neurology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. · C.S. Kubik Laboratory for Neuropathology, Massachusetts General Hospital, Charlestown, Massachusetts, USA. · Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, Indiana, USA. · Department of Surgery, University of Texas Southwestern Medical Center, Dallas, Texas, USA. · Alzheimer's Disease Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. · Department of Human Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. · Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri, USA. · Hope Center Program on Protein Aggregation and Neurodegeneration, Washington University School of Medicine, St. Louis, Missouri, USA. · Department of Neurology, Albert Einstein College of Medicine, Bronx, New York, USA. · Department of Mathematics and Statistics, Utah State University, Logan, Utah, USA. · Fundació per la Recerca Biomèdica i Social Mútua Terrassa, Terrassa, Barcelona, Spain. · Memory Unit, Department of Neurology, Hospital Universitario Mútua Terrassa, Terrassa, Barcelona, Spain. · Department of Old Age Psychiatry, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. · INSERM U558, University of Toulouse, Toulouse, France. · Elderly and Psychiatric Disorders Department, Medical University of Lodz, Lodz, Poland. · Department of Health Sciences, Psychiatry for the Elderly, University of Leicester, Leicester, UK. · Department of Neurodegenerative Disease, MRC Prion Unit, UCL Institute of Neurology, London, UK. · Department of Pathophysiology and Transplantation, University of Milan, Fondazione Ca' Granda, IRCCS Ospedale Policlinico, Milan, Italy. · Department of Psychiatry and Psychotherapy, University Hospital, Saarland, Germany. · Memory Unit, Neurology Department and Sant Pau Biomedical Research Institute, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain. · Regional Neurogenetic Centre (CRN), ASP Catanzaro, Lamezia Terme, Italy. · Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA. · NEUROFARBA (Department of Neuroscience, Psychology, Drug Research and Child Health), University of Florence, Florence, Italy. · IRCCS 'Don Carlo Gnocchi', Florence, Italy. · Institute for Medical Informatics, Biometry and Epidemiology, University Hospital of Essen, University Duisburg-Essen, Essen, Germany. · Department of Psychiatry and Psychotherapy, University of Erlangen-Nuremberg, Erlangen, Germany. · Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) Associazione Oasi Maria Santissima Srl, Troina, Italy. · Mercers Institute for Research on Aging, St. James Hospital and Trinity College, Dublin, Ireland. · Department of Molecular Neuroscience, UCL, Institute of Neurology, London, UK. · Department of Neurology, University of Michigan, Ann Arbor, Michigan, USA. · Geriatric Research, Education and Clinical Center (GRECC), VA Ann Arbor Healthcare System (VAAAHS), Ann Arbor, Michigan, USA. · Michigan Alzheimer Disease Center, Ann Arbor, Michigan, USA. · Indiana Alzheimer's Disease Center, Indiana University School of Medicine, Indianapolis, Indiana, USA. · Department of Medical and Molecular Genetics, Indiana University, Indianapolis, Indiana, USA. · Department of Neurology, Indiana University, Indianapolis, Indiana, USA. · Department of Radiology and Imaging Sciences, Indiana University, Indianapolis, Indiana, USA. · Department of Psychiatry, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. · Geriatric Research, Education and Clinical Center (GRECC), University of Wisconsin, Madison, Wisconsin, USA. · Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA. · Wisconsin Alzheimer's Disease Research Center, Madison, Wisconsin, USA. · Department of Medicine (Genetics Program), Boston University, Boston, Massachusetts, USA. · Department of Neurological Sciences, Rush University Medical Center, Chicago, Illinois, USA. · Department of Behavioral Sciences, Rush University Medical Center, Chicago, Illinois, USA. · Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA. · Civin Laboratory for Neuropathology, Banner Sun Health Research Institute, Phoenix, Arizona, USA. · Departments of Psychiatry, Neurology, and Psychology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, USA. · Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. · Cognitive Neurology and Alzheimer's Disease Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. · VA Puget Sound Health Care System/GRECC, Seattle, Washington, USA. · Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA. · Swedish Medical Center, Seattle, Washington, USA. · Department of Neurology, University of California, San Francisco, San Francisco, California, USA. · Department of Medicine, Duke University, Durham, North Carolina, USA. · University of Kansas Alzheimer's Disease Center, University of Kansas Medical Center, Kansas City, Kansas, USA. · Department of Genetics and Genomic Sciences, Mount Sinai School of Medicine, New York, New York, USA. · Department of Neuroscience, Mount Sinai School of Medicine, New York, New York, USA. · Department of Psychiatry, Mount Sinai School of Medicine, New York, New York, USA. · Department of Pathology and Immunology, Washington University, St. Louis, Missouri, USA. · USF Health Byrd Alzheimer's Institute, University of South Florida, Tampa, Florida, USA. · Fred Hutchinson Cancer Research Center, Seattle, Washington, USA. · Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, USA. · Department of Pathology and Laboratory Medicine, Medical University of South Carolina, Charleston, South Carolina, USA. · Department of Neurology, University of Southern California, Los Angeles, California, USA. · Department of Neurology, Medical University of South Carolina, Charleston, South Carolina, USA. · Department of Neurology, Ralph H. Johnson VA Medical Center, Charleston, South Carolina, USA. · Department of Neurology, University of California, Irvine, Irvine, California, USA. · Department of Neurology, University of California, Davis, Sacramento, California, USA. · Institute for Memory Impairments and Neurological Disorders, University of California, Irvine, Irvine, California, USA. · Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, Florida, USA. · Rush Institute for Healthy Aging, Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois, USA. · Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA. · Sanders-Brown Center on Aging, Department of Biostatistics, University of Kentucky, Lexington, Kentucky, USA. · Department of Psychiatry, New York University, New York, New York, USA. · Department of Neurosciences, University of California, San Diego, La Jolla, California, USA. · Department of Pathology and Laboratory Medicine, Emory University, Atlanta, Georgia, USA. · Emory Alzheimer's Disease Center, Emory University, Atlanta, Georgia, USA. · Neurogenetics Program, University of California, Los Angeles, Los Angeles, California, USA. · Department of Neurology, Mayo Clinic, Jacksonville, Florida, USA. · Division of Genetics, Department of Medicine and Partners Center for Personalized Genetic Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA. · Department of Neurology, Massachusetts General Hospital/Harvard Medical School, Boston, Massachusetts, USA. · Department of Pathology (Neuropathology), University of Pittsburgh, Pittsburgh, Pennsylvania, USA. · Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama, USA. · Neurogenomics Division, Translational Genomics Research Institute, Phoenix, Arizona, USA. · Department of Pathology, Duke University, Durham, North Carolina, USA. · Department of Genome Sciences, University of Washington, Seattle, Washington, USA. · Department of Medicine (Medical Genetics), University of Washington, Seattle, Washington, USA. · Sanders-Brown Center on Aging, College of Public Health, Department of Epidemiology, University of Kentucky, Lexington, Kentucky, USA. · Department of Pathology and Laboratory Medicine, University of California, Davis, Sacramento, California, USA. · Department of Biostatistics, Boston University, Boston, Massachusetts, USA. · Department of Ophthalmology, Boston University, Boston, Massachusetts, USA. · Department of Neurology, Oregon Health &Science University, Portland, Oregon, USA. · Department of Neurology, Portland Veterans Affairs Medical Center, Portland, Oregon, USA. · Department of Pathology and Laboratory Medicine, University of California, Irvine, Irvine, California, USA. · Department of Neurology, Boston University, Boston, Massachusetts, USA. · Department of Pathology, Boston University, Boston, Massachusetts, USA. · Department of Neuropsychology, University of California, San Francisco, San Francisco, California, USA. · Department of Neurobiology and Behavior, University of California, Irvine, Irvine, California, USA. · Department of Neurology, Emory University, Atlanta, Georgia, USA. · Cleveland Clinic Lou Ruvo Center for Brain Health, Cleveland Clinic, Cleveland, Ohio, USA. · Department of Pathology, University of Michigan, Ann Arbor, Michigan, USA. · Department of Psychiatry, Johns Hopkins University, Baltimore, Maryland, USA. · Department of Medicine-Pulmonary, New York University, New York, New York, USA. · Department of Neurology, University of Miami, Miami, Florida, USA. · Department of Pathology, University of California, San Diego, La Jolla, California, USA. · School of Nursing Northwest Research Group on Aging, University of Washington, Seattle, Washington, USA. · Department of Neurology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. · Department of Pathology, University of Southern California, Los Angeles, California, USA. · Department of Neurology, Washington University, St. Louis, Missouri, USA. · Internal Medicine, Division of Geriatrics, University of North Texas Health Science Center, Fort Worth, Texas, USA. · Department of Internal Medicine, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA. · Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA. · Department of Neurology, University of Colorado School of Medicine, Aurora, Colorado, USA. · Alzheimer's Disease Center, New York University, New York, New York, USA. · Department of Epidemiology, Columbia University, New York, New York, USA. · Department of Neurology, University of California, Los Angeles, Los Angeles, California, USA. · Tanz Centre for Research in Neurodegenerative Disease, University of Toronto, Toronto, Ontario, Canada. · Department of Neurology, University of Texas Southwestern Medical Center, Dallas, Texas, USA. · Department of Pathology (Neuropathology), Rush University Medical Center, Chicago, Illinois, USA. · Department of Psychiatry, University of Southern California, Los Angeles, California, USA. · Department of Pathology, University of Washington, Seattle, Washington, USA. · Translational Medicine, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts, USA. · Department of Pathology and Laboratory Medicine, University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA. · Department of Pathology, Johns Hopkins University, Baltimore, Maryland, USA. · Sanders-Brown Center on Aging, Department of Anatomy and Neurobiology, University of Kentucky, Lexington, Kentucky, USA. · Department of Pathology and Laboratory Medicine, University of California, Los Angeles, Los Angeles, California, USA. · Taub Institute on Alzheimer's Disease and the Aging Brain, Department of Pathology, Columbia University, New York, New York, USA. · Department of Psychiatry, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. · Department of Psychiatry and Behavioral Sciences, Duke University, Durham, North Carolina, USA. · Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA. · Department of Pathology, Oregon Health &Science University, Portland, Oregon, USA. · Evelyn F. McKnight Brain Institute, Department of Neurology, Miller School of Medicine, University of Miami, Miami, Florida, USA. · Department of Neurology and Memory Clinic, Hospital Network Antwerp, Antwerp, Belgium. · Laboratory for Cognitive Neurology, Department of Neurology, University of Leuven, Leuven, Belgium. (and more) ·Nat Genet · Pubmed #28714976.

ABSTRACT: We identified rare coding variants associated with Alzheimer's disease in a three-stage case-control study of 85,133 subjects. In stage 1, we genotyped 34,174 samples using a whole-exome microarray. In stage 2, we tested associated variants (P < 1 × 10

13 Article Impact of Recruitment Methods in Subjective Cognitive Decline. 2017

Abdelnour, Carla / Rodríguez-Gómez, Octavio / Alegret, Montserrat / Valero, Sergi / Moreno-Grau, Sonia / Sanabria, Ángela / Hernández, Isabel / Rosende-Roca, Maitee / Vargas, Liliana / Mauleón, Ana / Sánchez, Domingo / Espinosa, Ana / Ortega, Gemma / Pérez-Cordón, Alba / Diego, Susana / Gailhajanet, Anna / Guitart, Marina / Sotolongo-Grau, Óscar / Ruiz, Agustín / Tárraga, Lluís / Boada, Mercè. ·Alzheimer Research Center and Memory Clinic of Fundació ACE, Institut Catalá de Neurociències Aplicades, Barcelona, Spain. · Department of Psychiatry, Hospital Universitari Vall d'Hebron, CIBERSAM, Universitat Autònoma de Barcelona, Barcelona, Spain. ·J Alzheimers Dis · Pubmed #28269773.

ABSTRACT: BACKGROUND: Recruitment methods can determine sample characteristics in mild cognitive impairment and Alzheimer's disease dementia, but little is known about its influence in subjective cognitive decline (SCD). OBJECTIVE: To determine the influence of two types of recruitment methods in the characteristics of individuals with SCD. METHODS: We select and compare clinical and neuropsychological features, and frequency of APOE ɛ4 allele of 326 subjects with SCD from two cohorts: Open House Initiative (OHI) versus Memory Unit (MU). A logistic regression analysis (LRA), using gender and years of education as covariates, was used to examine the neuropsychological variables. RESULTS: The OHI sample were mostly women (75.9% versus 64.5%, p < 0.05), with higher educational level (12.15 [3.71] versus 10.70 [3.80] years, p = 0.001), and more family history of dementia (138 [62.7%] versus 44 [41.5%], p < 0.001) than the MU sample. Also, the OHI sample showed better overall neuropsychological performance than the MU sample, and after a LRA, this trend continued in automatic response inhibition capacity, abstract reasoning, and recognition memory. We did not find differences in age, depression history, and/or APOE ɛ4 allele frequency. CONCLUSION: SCD subjects showed different demographic and neuropsychological characteristics depending on the recruitment method, which should be taken into account in the design of research studies with this target population.

14 Article Genome-wide significant risk factors for Alzheimer's disease: role in progression to dementia due to Alzheimer's disease among subjects with mild cognitive impairment. 2017

Lacour, A / Espinosa, A / Louwersheimer, E / Heilmann, S / Hernández, I / Wolfsgruber, S / Fernández, V / Wagner, H / Rosende-Roca, M / Mauleón, A / Moreno-Grau, S / Vargas, L / Pijnenburg, Y A L / Koene, T / Rodríguez-Gómez, O / Ortega, G / Ruiz, S / Holstege, H / Sotolongo-Grau, O / Kornhuber, J / Peters, O / Frölich, L / Hüll, M / Rüther, E / Wiltfang, J / Scherer, M / Riedel-Heller, S / Alegret, M / Nöthen, M M / Scheltens, P / Wagner, M / Tárraga, L / Jessen, F / Boada, M / Maier, W / van der Flier, W M / Becker, T / Ramirez, A / Ruiz, A. ·German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. · Memory Clinic and Research Center of Fundación ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain. · Department of Neurology and Alzheimer Centre, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. · Institute of Human Genetics, University of Bonn, Bonn, Germany. · Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany. · Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany. · Alzheimer Center and Department of Clinical Genetics, Neuroscience Campus Amsterdam, VU University Medical Center, Amsterdam, The Netherlands. · Department of Psychiatry and Psychotherapy, University Clinic Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany. · Department of Psychiatry, Charité University Medicine, Berlin, Germany. · Department of Geriatric Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. · Center for Geriatric Medicine and Section of Gerontopsychiatry and Neuropsychology, Medical School, University of Freiburg, Freiburg, Germany. · Department of Psychiatry and Psychotherapy, University of Göttingen, Göttingen, Germany. · Department of Primary Medical Care, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. · Institute of Social Medicine, Occupational Health and Public Health, University of Leipzig, Leipzig, Germany. · Department of Psychiatry and Psychotherapy, Medical Faculty, University of Cologne, Cologne, Germany. · Department of Epidemiology and Biostatistics, VU University Medical Center, Amsterdam, The Netherlands. · Institute for Medical Biometry, Informatics and Epidemiology, University of Bonn, Bonn, Germany. ·Mol Psychiatry · Pubmed #26976043.

ABSTRACT: Few data are available concerning the role of risk markers for Alzheimer's disease (AD) in progression to AD dementia among subjects with mild cognitive impairment (MCI). We therefore investigated the role of well-known AD-associated single-nucleotide polymorphism (SNP) in the progression from MCI to AD dementia. Four independent MCI data sets were included in the analysis: (a) the German study on Aging, Cognition and Dementia in primary care patients (n=853); (b) the German Dementia Competence Network (n=812); (c) the Fundació ACE from Barcelona, Spain (n=1245); and (d) the MCI data set of the Amsterdam Dementia Cohort (n=306). The effects of single markers and combined polygenic scores were measured using Cox proportional hazards models and meta-analyses. The clusterin (CLU) locus was an independent genetic risk factor for MCI to AD progression (CLU rs9331888: hazard ratio (HR)=1.187 (1.054-1.32); P=0.0035). A polygenic score (PGS1) comprising nine established genome-wide AD risk loci predicted a small effect on the risk of MCI to AD progression in APOE-ɛ4 (apolipoprotein E-ɛ4) carriers (HR=1.746 (1.029-2.965); P=0.038). The novel AD loci reported by the International Genomics of Alzheimer's Project were not implicated in MCI to AD dementia progression. SNP-based polygenic risk scores comprising currently available AD genetic markers did not predict MCI to AD progression. We conclude that SNPs in CLU are potential markers for MCI to AD progression.

15 Article Evaluation of Candidate Genes Related to Neuronal Apoptosis in Late-Onset Alzheimer’s Disease. 2015

Moreno-Grau, Sonia / Barneda, Bruna / Carriba, Paulina / Marín, Juan / Sotolongo-Grau, Oscar / Hernández, Isabel / Rosende-Roca, Maitée / Mauleón, Ana / Vargas, Liliana / Espinosa, Ana / Alegret, Montserrat / Rodriguez, Octavio / Ortega, Gemma / Fernández, Maria Victoria / López-Arrieta, Jesús / Tárraga, Lluís / Boada, Mercè / Antúnez, Carmen / López, Joaquin / Ruiz, Agustín / Comella, Joan Xavier. ·Memory Clinic of Fundació ACE, Institut Català de Neurociències Aplicades, Barcelona, Spain. ·J Alzheimers Dis · Pubmed #25613099.

ABSTRACT: The objective of this study was to identify genetic variation in genes encoding death receptors and signals that modulate their activity. After conducting a meta-analysis with five previous genome-wide association studies and aggregated data, the most significant signals, (TNF locus: rs2395488, rs2534672, and rs9267445; and FASLG locus: rs730278), were replicated in 1,046 cases and 372 controls. The rs2395488 and rs2534672 markers showed a modest protective effect (OR = 0.849, p = 0.49780;OR= 0.687, p = 0.11335), in contrast to rs730278 marker (OR = 1.146, p = 0.17212), which did not follow the previous effect direction; in any case it reached the significance level. Final meta-analysis, adding the replication sample, confirmed these observations. We concluded that FASLG marker is not etiologically linked to Alzheimer’s disease. However, single nucleotide polymorphisms around TNF locus require further analyses in order to explain the association between Alzheimer’s disease and human leukocyte antigen.