Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Alzheimer Disease: HELP
Articles from Panum Institute
Based on 2 articles published since 2010
||||

These are the 2 published articles about Alzheimer Disease that originated from Panum Institute during 2010-2020.
 
+ Citations + Abstracts
1 Review NCAM2/OCAM/RNCAM: cell adhesion molecule with a role in neuronal compartmentalization. 2012

Winther, Malene / Berezin, Vladimir / Walmod, Peter Schledermann. ·Protein Laboratory, Department of Neuroscience and Pharmacology, Faculty of Health Sciences, University of Copenhagen, Panum Institute, Blegdamsvej 3C, Building 24.2, 2200 Copenhagen N., DK, Denmark. mwinther@sund.ku.dk ·Int J Biochem Cell Biol · Pubmed #22155300.

ABSTRACT: Neural cell adhesion molecules 2 (NCAM2/OCAM/RNCAM), is a paralog of NCAM1. The protein exists in a transmembrane and a lipid-anchored isoform, and has an ectodomain consisting of five immunoglobulin modules and two fibronectin type 3 homology modules. Structural models of the NCAM2 ectodomain reveal that it facilitates cell adhesion through reciprocal interactions between the membrane-distal immunoglobulin modules. There are no known heterophilic NCAM2 binding partners, and NCAM2 is not glycosylated with polysialic acid, a posttranslational modification known to be a major modulator of NCAM1-mediated processes. This suggests that NCAM2 has a function or mode of action distinctly different from that of NCAM1. NCAM2 is primarily expressed in the brain, where it is believed to stimulate neurite outgrowth and to facilitate dendritic and axonal compartmentalization.

2 Article Diagnostic manifestations of total hemispheric glucose metabolism ratio in neuronal network diaschisis: diagnostic implications in Alzheimer's disease and mild cognitive impairment. 2019

Segtnan, Eivind A / Majdi, Alireza / Constantinescu, Caius / Grupe, Peter / Gerke, Oke / Dali, Heini Í / Strøm, Olaf Emil / Holm, Jorun / Alavi, Abass / Sadigh-Eteghad, Saeed / Wermuth, Lene / Hildebrandt, Malene G / Gjedde, Albert / Høilund-Carlsen, Poul Flemming. ·Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark. · Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. · Neurosciences Research Center, Tabriz University of Medical Sciences, Tabriz, Iran. · Division of Nuclear Medicine, Department of Radiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. · Dementia Clinic, Department of Neurology, Odense University Hospital, Odense C, Denmark. · Department of Neuroscience, Panum Institute, University of Copenhagen, Copenhagen, Denmark. · Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark. pfhc@rsyd.dk. · Department of Clinical Research, Faculty of Health Sciences, University of Southern Denmark, Odense, Denmark. pfhc@rsyd.dk. ·Eur J Nucl Med Mol Imaging · Pubmed #30637500.

ABSTRACT: PURPOSE: We tested the hypothesis that lateralized hemispheric glucose metabolism may have diagnostic implications in Alzheimer's disease (AD) and mild cognitive impairment (MCI). METHODS: We performed FDG-PET/CT in 23 patients (mean age 63.7 years, range 50-78, 17 females) diagnosed with AD (n = 15) or MCI (n = 8) during a six-month period in 2014. Ten neurologically healthy individuals (HIs) (mean age 62.5 years, range 43-75, 5 females) served as controls. A neuroimaging expert provided visual assessment of diaschisis. The total hemispheric glucose metabolism ratio (THGr) was calculated, and with area-under the curve of receiver operating characteristics (AUC-ROC) we generated a "Network Diaschisis Test (NDT)". RESULTS: The qualitative detection of cerebral (Ce) and cerebellar (Cb) diaschisis was 7/15 (47%), 0/8 (0%), and 0/10 (0%) in AD, MCI, and HI groups, respectively. Median cerebral THGr was 0.68 (range 0.43-0.99), 0.86 (range 0.64-0.98), and 0.95 (range 0.65-1.00) for AD, MCI, and HI groups, respectively (p = 0.04). Median cerebellar THGr was, respectively, 0.70 (range 0.18-0.98), 0.70 (range 0.48-0.81), and 0.84 (range 0.75-0.96) (p = 0.0138). A positive NDT yielded a positive predictive value of 100% for the presence of AD or MCI and a 86% negative predictive value for healthy brain. Moreover, the diagnostic manifestation of THGr between MCI and AD led to a positive predictive value of 100% for AD, but a negative predictive value of 42.9% for MCI. CONCLUSION: Patients with AD or MCI had more pronounced diaschisis, lateralized hemispheric glucose metabolism and lower THGr compared to healthy controls. The NDT distinguished AD and MCI patients from HIs, and AD from MCI patients with a high positive predictive value and moderate and low negative predictive values. THGr can be a straightforward source of investigating neuronal network diaschisis in AD and MCI and in other cerebral diseases, across institutions.