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Autistic Disorder: HELP
Articles from New England
Based on 621 articles published since 2008

These are the 621 published articles about Autistic Disorder that originated from New England during 2008-2019.
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14 · 15 · 16 · 17 · 18 · 19 · 20
1 Editorial At the Intersection of Neurodiversity and Gender Diversity. 2018

van Schalkwyk, Gerrit Ian. ·Warren Alpert Medical School of Brown University, 345 Blackstone Boulevard, Providence, RI, 02906, USA. Gerrit_Van_schalkwyk@brown.edu. ·J Autism Dev Disord · Pubmed #30220017.


2 Editorial Music Therapy for Children With Autism Spectrum Disorder. 2017

Broder-Fingert, Sarabeth / Feinberg, Emily / Silverstein, Michael. ·Department of Pediatrics, Boston University School of Medicine, Boston, Massachusetts. · Boston Medical Center, Boston, Massachusetts. · Department of Community Health Sciences, Boston University School of Public Health, Boston, Massachusetts. ·JAMA · Pubmed #28787492.

ABSTRACT: -- No abstract --

3 Editorial Serum Zonulin, Gut Permeability, and the Pathogenesis of Autism Spectrum Disorders: Cause, Effect, or an Epiphenomenon? 2017

Fasano, Alessio / Hill, Ivor. ·Harvard Medical School Division of Pediatric Gastroenterology and Nutrition and Mucosal Immunology and Biology Research Center Massachusetts General Hospital for Children Boston, Massachusetts. · The Ohio State University College of Medicine Gastroenterology Nationwide Children's Hospital Columbus, Ohio. Electronic address: Ivor.Hill@nationwidechildrens.org. ·J Pediatr · Pubmed #28624097.

ABSTRACT: -- No abstract --

4 Editorial Public Perception, Autism, and the Importance of Violence Subtypes. 2017

Westphal, Alexander. ·Division of Law and Psychiatry, Yale School of Medicine and Yale Child Study Center, New Haven, CT. Electronic address: alexander.westphal@yale.edu. ·J Am Acad Child Adolesc Psychiatry · Pubmed #28545749.

ABSTRACT: -- No abstract --

5 Editorial Commentary on USPSTF Final Statement on Universal Screening for Autism. 2016

Fein, Deborah / Anonymous2100877. ·Departments of Psychology and Pediatrics, University of Connecticut, Storrs, CT. ·J Dev Behav Pediatr · Pubmed #27490701.

ABSTRACT: -- No abstract --

6 Editorial Rigid, Inflexible Approach Results in No Recommendation for Autism Screening. 2016

Veenstra-VanderWeele, Jeremy / McGuire, Kelly. ·Sackler Institute for Developmental Psychobiology, Department of Psychiatry, Columbia University, New York, New York2New York State Psychiatric Institute, New York3Center for Autism and the Developing Brain, New York Presbyterian Hospital, New York. · Center for Autism and Developmental Disorders, Maine Behavioral Healthcare, Portland. ·JAMA Psychiatry · Pubmed #26881781.

ABSTRACT: -- No abstract --

7 Editorial Introduction to Technologies in the Daily Lives of Individuals with Autism. 2015

Shic, Frederick / Goodwin, Matthew. ·Yale Child Study Center, School of Medicine, Yale University, 40 Temple St Suite 7D, New Haven, CT, 06510, USA. frederick.shic@yale.edu. · Department of Health Sciences, College of Computer and Information Science, Northeastern University, 312E Robinson Hall, 360 Huntington Ave, Boston, MA, 02115, USA. m.goodwin@neu.edu. ·J Autism Dev Disord · Pubmed #26530715.

ABSTRACT: In this introduction to the Special Issue on Technology we explore the continued evolution of technologies designed to help individuals with autism. Through review articles, empirical reports, and perspectives, we examine how far the field has come and how much further we still can go. Notably, even as we highlight the continuing need for larger empirical studies of autism-focused technology, we note how improvements in the portability, sophistication, ubiquity, and reach of daily technologies are providing new opportunities for research, education, enhancement, knowledge, and inspiration. We conclude by discussing how the next generation of technologies may leverage the increasing promise of big-data approaches to move us towards a future where technology is more personal, more relevant, and pervasively transformative.

8 Editorial Occupational Therapy: Meeting the Needs of Families of People With Autism Spectrum Disorder. 2015

Kuhaneck, Heather Miller / Watling, Renee. ·Heather Miller Kuhaneck, PhD, OTR/L, FAOTA, is Associate Professor, Department of Occupational Therapy, Sacred Heart University, Fairfield, CT; kuhaneckh@sacredheart.edu. · Renee Watling, PhD, OTR/L, FAOTA, is Visiting Assistant Professor, School of Occupational Therapy, University of Puget Sound, Tacoma, WA. This work was completed while Dr. Watling was at the University of Washington, Seattle. ·Am J Occup Ther · Pubmed #26356652.

ABSTRACT: Occupational therapy has much to offer to families of people with autism spectrum disorder (ASD). However, people outside the profession may be unaware of occupational therapy's breadth and scope. It is our responsibility and our duty to express the full range of occupational therapy services through research, clinical practice, advocacy, and consumer education. This special issue of the American Journal of Occupational Therapy, with its focus on autism, embarks on this endeavor by highlighting research and theoretical articles that address the various aspects of occupational therapy practice that can help to fully meet the needs of people with ASD and their families.

9 Editorial Quantifying the effects of rare variants in pedigrees: how far does the apple fall from the tree? 2015

Morrow, Eric M. ·Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, Rhode Island2Institute for Brain Science, Laboratory for Molecular Medicine, Brown University, Providence, Rhode Island3Developmental Disorders Genetics Researc. ·JAMA Psychiatry · Pubmed #25493613.

ABSTRACT: -- No abstract --

10 Editorial Promoting communicative speech in minimally verbal children with autism spectrum disorder. 2014

Tager-Flusberg, Helen. ·Boston University. Electronic address: htagerf@bu.edu. ·J Am Acad Child Adolesc Psychiatry · Pubmed #24839879.

ABSTRACT: -- No abstract --

11 Editorial Is the prevalence of autism increasing in the United States? 2014

Blenner, Stephanie / Augustyn, Marilyn. ·Division of Developmental Behavioral Pediatrics, Boston University School of Medicine, Boston, MA 02118, USA. ·BMJ · Pubmed #24817069.

ABSTRACT: -- No abstract --

12 Editorial Autism risk in very preterm infants--new answers, more questions. 2014

Hofheimer, Julie A / Sheinkopf, Stephen J / Eyler, Lisa T. ·Division of Neonatal-Perinatal Medicine, Department of Pediatrics, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina. Electronic address: julie_hofheimer@med.unc.edu. · Department of Psychiatry and Human Behavior, Warren Alpert Medical School of Brown University and Women & Infants Hospital of Rhode Island, Providence, Rhode Island. · Department of Psychiatry and Autism Center, University of California at San Diego, Mental Illness, Research, Education, and Clinical Center, VA San Diego Healthcare System, San Diego, California. ·J Pediatr · Pubmed #24359898.

ABSTRACT: -- No abstract --

13 Editorial Autism and developmental disorders: management of serious behavioral disturbance. 2014

Siegel, Matthew / King, Bryan H. ·Developmental Disorders Program, Spring Harbor Hospital, 123 Andover Road, Westbrook, ME 04092, USA. Electronic address: siegem@springharbor.org. ·Child Adolesc Psychiatr Clin N Am · Pubmed #24231174.

ABSTRACT: -- No abstract --

14 Editorial Can we measure autism? 2013

Kohane, Isaac S / Eran, Alal. ·Isaac S. Kohane is Co-Director of the Center for Biomedical Informatics, Harvard Medical School, Boston, MA 02115, USA, and the Lawrence J. Henderson Professor of Pediatrics, Children's Hospital, Boston, MA 02115, USA. isaac_kohane@harvard.edu. ·Sci Transl Med · Pubmed #24174324.

ABSTRACT: Newly released definitions of autism spectrum disorder demonstrate the need for precise diagnoses informed by the integration of clinical, molecular, and biochemical characteristics in a patient-information commons.

15 Review Autism BrainNet: A network of postmortem brain banks established to facilitate autism research. 2018

Amaral, David G / Anderson, Matthew P / Ansorge, Olaf / Chance, Steven / Hare, Carolyn / Hof, Patrick R / Miller, Melissa / Nagakura, Ikue / Pickett, Jane / Schumann, Cynthia / Tamminga, Carol. ·The MIND Institute, University of California at Davis, Sacramento, CA, United States. Electronic address: dgamaral@ucdavis.edu. · Department of Neurology and Pathology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, United States. · Nuffield Department of Clinical Neurosciences, Academic Unit of Neuropathology, John Radcliffe Hospital, University of Oxford, Oxford, United Kingdom. · Autism BrainNet, Foundation Associates, New York, NY, United States. · Department of Neuroscience, Icahn School of Medicine at Mount Sinai, New York, NY, United States. · The MIND Institute, University of California at Davis, Sacramento, CA, United States. · Department of Psychiatry, UT Southwestern, Dallas, TX, United States. ·Handb Clin Neurol · Pubmed #29496150.

ABSTRACT: Autism spectrum disorder (ASD or autism) is a neurodevelopmental condition that affects over 1% of the population worldwide. Developing effective preventions and treatments for autism will depend on understanding the genetic perturbations and underlying neuropathology of the disorder. While evidence from magnetic resonance imaging and other noninvasive techniques points to altered development and organization of the autistic brain, these tools lack the resolution for identifying the cellular and molecular underpinnings of the disorder. Postmortem studies of high-quality human brain tissue currently represent the only viable option to pursuing these types of studies. However, the availability of high-quality ASD brain tissue has been extremely limited. Here we describe the establishment of a privately funded tissue bank, Autism BrainNet, a network of brain collection sites that work in a coordinated fashion to develop an adequate library of human postmortem brain tissues. Autism BrainNet was initiated as a collaboration between the Simons Foundation and Autism Speaks, and is currently funded by the Simons Foundation Autism Research Initiative. Autism BrainNet has collection sites (nodes) in California, Texas, New York, and Massachusetts; an affiliated, international node is located in Oxford, England. All donations to this network become part of a consolidated pool of tissue that is distributed to qualified investigators worldwide to carry out autism research. An essential component of this program is a widespread outreach program that highlights the need for postmortem brain donations to families affected by autism, led by the Autism Science Foundation. Challenges include an outreach campaign that deals with a disorder beginning in early childhood, collecting an adequate number of donations to deal with the high level of biologic heterogeneity of autism, and preparing this limited resource for optimal distribution to the greatest number of investigators.

16 Review Abnormal mTOR Activation in Autism. 2018

Winden, Kellen D / Ebrahimi-Fakhari, Darius / Sahin, Mustafa. ·F.M. Kirby Neurobiology Center, Translational Neuroscience Center, Department of Neurology, Boston Children's Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA; email: mustafa.sahin@childrens.harvard.edu. ·Annu Rev Neurosci · Pubmed #29490194.

ABSTRACT: The mechanistic target of rapamycin (mTOR) is an important signaling hub that integrates environmental information regarding energy availability and stimulates anabolic molecular processes and cell growth. Abnormalities in this pathway have been identified in several syndromes in which autism spectrum disorder (ASD) is highly prevalent. Several studies have investigated mTOR signaling in developmental and neuronal processes that, when dysregulated, could contribute to the development of ASD. Although many potential mechanisms still remain to be fully understood, these associations are of great interest because of the clinical availability of mTOR inhibitors. Clinical trials evaluating the efficacy of mTOR inhibitors to improve neurodevelopmental outcomes have been initiated.

17 Review Repint of "Reframing autism as a behavioral syndrome and not a specific mental disorder: Implications of genetic and phenotypic heterogeneity". 2018

Tordjman, S / Cohen, D / Anderson, G M / Botbol, M / Canitano, R / Coulon, N / Roubertoux, P L. ·Pôle Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Université de Rennes 1 and Centre Hospitalier Guillaume Régnier, 154 rue de Châtillon, 35200 Rennes, France; Laboratoire Psychologie de la Perception, Université Paris Descartes and CNRS UMR 8158, Paris, France. Electronic address: s.tordjman@yahoo.fr. · Department of Child and Adolescent Psychiatry, AP-HP, GH Pitié-Salpétrière, CNRS FRE 2987, Université Pierre et Marie Curie, Paris, France. · Child Study Center, Yale University School of Medicine, New Haven, CT, USA. · Departement Hospitalo-Universitaire de Psychiatrie de l'Enfant et de l'Adolescent, Université de Bretagne Occidentale, Brest, France. · Division of Child and Adolescent Neuropsychiatry, University Hospital of Siena, Italy. · Laboratoire Psychologie de la Perception, Université Paris Descartes and CNRS UMR 8158, Paris, France. · Aix Marseille Université, GMGF, Inserm, UMR_S 910, 13385, Marseille, France. ·Neurosci Biobehav Rev · Pubmed #29391184.

ABSTRACT: Clinical and molecular genetics have advanced current knowledge on genetic disorders associated with autism. A review of diverse genetic disorders associated with autism is presented and for the first time discussed extensively with regard to possible common underlying mechanisms leading to a similar cognitive-behavioral phenotype of autism. The possible role of interactions between genetic and environmental factors, including epigenetic mechanisms, is in particular examined. Finally, the pertinence of distinguishing non-syndromic autism (isolated autism) from syndromic autism (autism associated with genetic disorders) will be reconsidered. Given the high genetic and etiological heterogeneity of autism, autism can be viewed as a behavioral syndrome related to known genetic disorders (syndromic autism) or currently unknown disorders (apparent non-syndromic autism), rather than a specific categorical mental disorder. It highlights the need to study autism phenotype and developmental trajectory through a multidimensional, non-categorical approach with multivariate analyses within autism spectrum disorder but also across mental disorders, and to conduct systematically clinical genetic examination searching for genetic disorders in all individuals (children but also adults) with autism.

18 Review Gut-immune-brain dysfunction in Autism: Importance of sex. 2018

Kopec, Ashley M / Fiorentino, Maria R / Bilbo, Staci D. ·Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Lurie Center for Autism, Massachusetts General Hospital for Children, Boston, MA, USA. · Mucosal Immunology and Biology Research Center, Massachusetts General Hospital for Children, Boston, MA, USA. · Department of Pediatrics, Harvard Medical School, Boston, MA, USA; Lurie Center for Autism, Massachusetts General Hospital for Children, Boston, MA, USA. Electronic address: sbilbo@mgh.harvard.edu. ·Brain Res · Pubmed #29360468.

ABSTRACT: Autism Spectrum Disorder (ASD) is characterized by social behavior deficits, stereotypies, cognitive rigidity, and in some cases severe intellectual impairment and developmental delay. Although ASD is most widely identified by its neurological deficits, gastrointestinal issues are common in ASD. An intimate and complex relationship exists between the gut, the immune system, and the brain, leading to the hypothesis that ASD may be a systems-level disease affecting the gut and immune systems, in addition to the brain. Despite significant advances in understanding the contribution of the gut and immune systems to the etiology of ASD, there is an intriguing commonality among patients that is not well understood: they are predominantly male. Virtually no attention has been given to the potential role of sex-specific regulation of gut, peripheral, and central immune function in ASD, despite the 4:1 male-to-female bias in this disorder. In this review, we discuss recent revelations regarding the impact of gut-immune-brain relationships on social behavior in rodent models and in ASD patients, placing them in the context of known or putative sex specific mechanisms.

19 Review Supporting Children with Autism and Their Families: A Culturally Responsive Family-Driven Interprofessional Process. 2018

Potvin, Marie-Christine / Prelock, Patricia A / Savard, Liliane. ·Philadelphia University, 4201 Henry Avenue, Philadelphia, PA 19144-5497, USA. · University of Vermont, Dean's Office, College of Nursing and Health Sciences, 106 Carrigan Drive, 105 Rowell Building, Burlington, VT 05405, USA. Electronic address: patricia.prelock@med.uvm.edu. · University of Vermont Zippy Life Physical Therapy pllc, 32 Main Street, Suite 206, Montpelier, VT 05602, USA. ·Pediatr Clin North Am · Pubmed #29173719.

ABSTRACT: This article describes the Coaching in Context (CinC) process, a family-driven, culturally responsive structure that facilitates family identification and achievement of goals. CinC focuses on modification of the demands of an activity with guidance from a health care professional who coaches the family to increase their participation in everyday activities. An interprofessional team is key in this process. Working as a team and communicating effectively across professions supports the health professional who serves as the coach. Effective interprofessional team collaboration is possible; health professions share values for the delivery of the highest quality of care.

20 Review Translating genetic and preclinical findings into autism therapies. 2017

Chahrour, Maria / Kleiman, Robin J / Manzini, M Chiara. ·Eugene McDermott Center for Human Growth and Development, Departments of Neuroscience and Psychiatry, University of Texas Southwestern Medical Center, Dallas, Texas, USA. · Research and Early Development, Biogen, Cambridge MA, USA. · Institute for Neuroscience, Autism and Neurodevelopmental Disorders Institute, and Department of Pharmacology and Physiology, The George Washington University School of Medicine and Health Sciences, Washington, DC, USA. ·Dialogues Clin Neurosci · Pubmed #29398929.

ABSTRACT: Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder characterized by social deficits and repetitive/restrictive interests. ASD is associated with multiple comorbidities, including intellectual disability, anxiety, and epilepsy. Evidence that ASD is highly heritable has spurred major efforts to unravel its genetics, revealing possible contributions from hundreds of genes through rare and common variation and through copy-number changes. In this perspective, we provide an overview of the current state of ASD genetics and of how genetic research has spurred the development of in vivo and in vitro models using animals and patient cells to evaluate the impact of genetic mutations on cellular function leading to disease. Efforts to translate these findings into successful therapies have yet to bear fruit. We discuss how the valuable insight into the disorder provided by these new models can be used to better understand ASD and develop future clinical trials.

21 Review Facilitating Autism Research. 2017

Fein, Deborah / Helt, Molly. ·1Departments of Psychological Sciences and Pediatrics,University of Connecticut,Storrs,Connecticut. · 2Departments of Psychology and Neuroscience,Trinity College,Hartford,Connecticut. ·J Int Neuropsychol Soc · Pubmed #29198284.

ABSTRACT: Early autism research focused on behavior and cognition. In recent decades, the pace of research has accelerated, and advances in imaging and genetics have allowed the accumulation of biological data. Nevertheless, a coherent picture of the syndrome at either phenotypic or biological level has not emerged. We see two fundamental obstacles to progress in basic understanding of autism. First, the two defining features (impairment in social interactions and communication, and restricted, repetitive behaviors and interests) are historically seen as integrally related. Others hold that these two major traits are fractionable and must be studied independently, casting doubt on autism as a coherent syndrome. Second, despite much recent research on brain structure and function, environmental factors, and genetics/genomics, findings on the biological level have not generally aligned well with those on the phenotypic level. In the first two sections, we explore these challenges, and in the third section, we review approaches that may facilitate progress, such as (1) including in studies all individuals defined by social impairment without regard to repetitive behaviors, (2) forming narrowly defined subtypes by thorough characterization on specific features, both diagnostic and non-diagnostic, (3) focusing on characteristics that may be relatively robust to environmental influence, (4) studying children as early as possible, minimizing environmental influence, and including longitudinal course as an important part of the phenotype, (5) subtyping by environmental risk factors, (6) distinguishing between what participants can do and what they typically do, and (7) aggregating large data sets across sites. (JINS, 2017, 23, 903-915).

22 Review Acetylcholine Neuromodulation in Normal and Abnormal Learning and Memory: Vigilance Control in Waking, Sleep, Autism, Amnesia and Alzheimer's Disease. 2017

Grossberg, Stephen. ·Center for Adaptive Systems, Graduate Program in Cognitive and Neural Systems, Departments of Mathematics & Statistics, Psychological & Brain Sciences and Biomedical Engineering, Boston University, Boston, MA, United States. ·Front Neural Circuits · Pubmed #29163063.

ABSTRACT: Adaptive Resonance Theory, or ART, is a neural model that explains how normal and abnormal brains may learn to categorize and recognize objects and events in a changing world, and how these learned categories may be remembered for a long time. This article uses ART to propose and unify the explanation of diverse data about normal and abnormal modulation of learning and memory by acetylcholine (ACh). In ART,

23 Review Interprofessional Education and Practice: A Family-Centered Approach to Autism. 2017

Prelock, Patricia A / Potvin, Marie-Christine / Savard, Liliane. ·College of Nursing and Health Sciences, University of Vermont, Burlington, Vermont. · Philadelphia University, Philadelphia, Pennsylvania. · University of Vermont, Burlington, Vermont. ·Semin Speech Lang · Pubmed #29078221.

ABSTRACT: -- No abstract --

24 Review Sensory perception in autism. 2017

Robertson, Caroline E / Baron-Cohen, Simon. ·Harvard Society of Fellows, Harvard University, Cambridge, Massachusetts, 02138, USA. · McGovern Institute for Brain Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA. · Department of Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire, 03755, USA. · Autism Research Centre, Department of Psychiatry, Cambridge University, Cambridge, CB2 8AH, UK. ·Nat Rev Neurosci · Pubmed #28951611.

ABSTRACT: Autism is a complex neurodevelopmental condition, and little is known about its neurobiology. Much of autism research has focused on the social, communication and cognitive difficulties associated with the condition. However, the recent revision of the diagnostic criteria for autism has brought another key domain of autistic experience into focus: sensory processing. Here, we review the properties of sensory processing in autism and discuss recent computational and neurobiological insights arising from attention to these behaviours. We argue that sensory traits have important implications for the development of animal and computational models of the condition. Finally, we consider how difficulties in sensory processing may relate to the other domains of behaviour that characterize autism.

25 Review Microglia emerge as central players in brain disease. 2017

Salter, Michael W / Stevens, Beth. ·Neurosciences &Mental Health Program, Hospital for Sick Children, Department of Physiology, Faculty of Medicine, University of Toronto, Toronto, Ontario, Canada. · F.M. Kirby Neurobiology Center, Boston Children's Hospital and Harvard Medical School, Boston, Massachusetts, Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, United States. ·Nat Med · Pubmed #28886007.

ABSTRACT: There has been an explosion of new findings recently giving us insights into the involvement of microglia in central nervous system (CNS) disorders. A host of new molecular tools and mouse models of disease are increasingly implicating this enigmatic type of nervous system cell as a key player in conditions ranging from neurodevelopmental disorders such as autism to neurodegenerative disorders such as Alzheimer's disease and chronic pain. Contemporaneously, diverse roles are emerging for microglia in the healthy brain, from sculpting developing neuronal circuits to guiding learning-associated plasticity. Understanding the physiological functions of these cells is crucial to determining their roles in disease. Here we focus on recent developments in our rapidly expanding understanding of the function, as well as the dysfunction, of microglia in disorders of the CNS.