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Chronic Fatigue Syndrome: HELP
Articles from Africa
Based on 11 articles published since 2010
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These are the 11 published articles about Fatigue Syndrome, Chronic that originated from Africa during 2010-2020.
 
+ Citations + Abstracts
1 Review Infection Elicited Autoimmunity and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: An Explanatory Model. 2018

Blomberg, Jonas / Gottfries, Carl-Gerhard / Elfaitouri, Amal / Rizwan, Muhammad / Rosén, Anders. ·Department of Medical Sciences, Uppsala University, Clinical Microbiology, Academic Hospital, Uppsala, Sweden. · Gottfries Clinic AB, Mölndal, Sweden. · Department of Infectious Disease and Tropical Medicine, Faculty of Public Health, Benghazi University, Benghazi, Libya. · Department of Clinical and Experimental Medicine, Division of Cell Biology, Linköping University, Linköping, Sweden. ·Front Immunol · Pubmed #29497420.

ABSTRACT: Myalgic encephalomyelitis (ME) often also called chronic fatigue syndrome (ME/CFS) is a common, debilitating, disease of unknown origin. Although a subject of controversy and a considerable scientific literature, we think that a solid understanding of ME/CFS pathogenesis is emerging. In this study, we compiled recent findings and placed them in the context of the clinical picture and natural history of the disease. A pattern emerged, giving rise to an explanatory model. ME/CFS often starts after or during an infection. A logical explanation is that the infection initiates an autoreactive process, which affects several functions, including brain and energy metabolism. According to our model for ME/CFS pathogenesis, patients with a genetic predisposition and dysbiosis experience a gradual development of B cell clones prone to autoreactivity. Under normal circumstances these B cell offsprings would have led to tolerance. Subsequent exogenous microbial exposition (triggering) can lead to comorbidities such as fibromyalgia, thyroid disorder, and orthostatic hypotension. A decisive infectious trigger may then lead to immunization against autoantigens involved in aerobic energy production and/or hormone receptors and ion channel proteins, producing postexertional malaise and ME/CFS, affecting both muscle and brain. In principle, cloning and sequencing of immunoglobulin variable domains could reveal the evolution of pathogenic clones. Although evidence consistent with the model accumulated in recent years, there are several missing links in it. Hopefully, the hypothesis generates testable propositions that can augment the understanding of the pathogenesis of ME/CFS.

2 Article Antibodies to Human Herpesviruses in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome Patients. 2019

Blomberg, Jonas / Rizwan, Muhammad / Böhlin-Wiener, Agnes / Elfaitouri, Amal / Julin, Per / Zachrisson, Olof / Rosén, Anders / Gottfries, Carl-Gerhard. ·Section of Clinical Microbiology, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. · Department of Infectious Disease and Tropical Medicine, Faculty of Public Health, Benghazi University, Benghazi, Libya. · Neurological Rehabilitation Clinic, Stora Sköndal, Sköndal, Sweden. · Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden. · Gottfries Clinic AB, Mölndal, Sweden. · Division of Cell Biology, Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden. ·Front Immunol · Pubmed #31475007.

ABSTRACT: Myalgic encephalomyelitis, also referred to as chronic fatigue syndrome (ME/CFS) is a debilitating disease characterized by myalgia and a sometimes severe limitation of physical activity and cognition. It is exacerbated by physical and mental activity. Its cause is unknown, but frequently starts with an infection. The eliciting infection (commonly infectious mononucleosis or an upper respiratory infection) can be more or less well diagnosed. Among the human herpesviruses (HHV-1-8), HHV-4 (Epstein-Barr virus; EBV), HHV-6 (including HHV-6A and HHV-6B), and HHV-7, have been implicated in the pathogenesis of ME/CFS. It was therefore logical to search for serological evidence of past herpesvirus infection/reactivation in several cohorts of ME/CFS patients (all diagnosed using the Canada criteria). Control samples were from Swedish blood donors. We used whole purified virus, recombinant proteins, and synthetic peptides as antigens in a suspension multiplex immunoassay (SMIA) for immunoglobulin G (IgG). The study on herpesviral peptides based on antigenicity with human sera yielded novel epitope information. Overall, IgG anti-herpes-viral reactivities of ME/CFS patients and controls did not show significant differences. However, the high precision and internally controlled format allowed us to observe minor relative differences between antibody reactivities of some herpesviral antigens in ME/CFS versus controls. ME/CFS samples reacted somewhat differently from controls with whole virus HHV-1 antigens and recombinant EBV EBNA6 and EA antigens. We conclude that ME/CFS samples had similar levels of IgG reactivity as blood donor samples with HHV-1-7 antigens. The subtle serological differences should not be over-interpreted, but they may indicate that the immune system of some ME/CFS patients interact with the ubiquitous herpesviruses in a way different from that of healthy controls.

3 Article Biotransformation profiles from a cohort of chronic fatigue women in response to a hepatic detoxification challenge. 2019

Erasmus, Elardus / Steffens, Francois E / van Reenen, Mari / Vorster, B Chris / Reinecke, Carolus J. ·Human Metabolomics, North-West University (Potchefstroom Campus), South Africa. · Department of Consumer Science, University of Pretoria, Pretoria, South Africa. ·PLoS One · Pubmed #31075116.

ABSTRACT: Chronic fatigue, in its various manifestations, frequently co-occur with pain, sleep disturbances and depression and is a non-communicable condition which is rapidly becoming endemic worldwide. However, it is handicapped by a lack of objective definitions and diagnostic measures. This has prompted the World Health Organization to develop an international instrument whose intended purpose is to improve quality of life (QOL), with energy and fatigue as one domain of focus. To complement this objective, the interface between detoxification, the exposome, and xenobiotic-sensing by nuclear receptors that mediate induction of biotransformation-linked genes, is stimulating renewed attention to a rational development of strategies to identify the metabolic profiles in complex multifactorial conditions like fatigue. Here we present results from a seven-year study of a cohort of 576 female patients suffering from low to high levels of chronic fatigue, in which phase I and phase II biotransformation was assessed. The biotransformation profiles used were based on hepatic detoxification challenge tests through oral caffeine, acetaminophen and acetylsalicylic acid ingestion coupled with oxidative stress analyses. The interventions indicated normal phase I but increased phase II glucuronidation and glycination conjugation. Complementarity was indicated between a fatigue scale, medical symptoms and associated energy-related parameters by application of Chi-square Automatic Interaction Detector (CHAID) analysis. The presented study provides a cluster of data from which we propose that multidisciplinary inputs from the combination of a fatigue scale, medical symptoms and biotransformation profiles provide the rationale for the development of a comprehensive laboratory instrument for improved diagnostics and personalized interventions in patients with chronic fatigue with a view to improving their QOL.

4 Article The relationship between chronic fatigue syndrome, burnout, job satisfaction, social support and age among academics at a tertiary institution 2019

Coetzee, Nicoleen / Maree, David Jacobus Francois / Smit, Byron Nel. ·University of Pretoria, Pretoria, South Africa (Department of Psychology) ·Int J Occup Med Environ Health · Pubmed #30855100.

ABSTRACT: Objectives: Over the last 20 years, tertiary institutions have been subjected to several changes. This has resulted in increased workloads for academics. Some academics have started to experience symptoms that are related to chronic fatigue syndrome and burnout. Researchers, however, cannot agree whether the 2 syndromes are two sides of the same coin or actually 2 separate constructs. This study that was conducted at a tertiary institution in South Africa therefore aimed to determine if these constructs accounted for the evidence of the same syndrome within an academic setting or if they were 2 separate, distinguishable constructs. However, since job satisfaction and social support play a role in the poor physical and psychological health experienced by individuals with chronic fatigue syndrome or burnout, it was decided to also include these 2 constructs into the investigation. Age was also incorporated because it had dissimilar relationships with burnout and chronic fatigue syndrome. Material and Methods: The participants completed the following questionnaires via an online survey: The Centers for Disease Control and Prevention Chronic Fatigue Syndrome Symptom Inventory, the Oldenburg Burnout Inventory, the Overall Job Satisfaction Scale and the Social Support Scale. The data was used for constructing a structural equation model. Results: Job satisfaction was found to be a strong predictor of burnout. The number of symptoms indicative of chronic fatigue syndrome reported by the participants proved to be a relatively strong significant predictor of burnout. Age did not yield any significant relationship with any of the constructs. Conclusions: The results indicated that chronic fatigue and burnout should be perceived as 2 distinguishable constructs in the academic context. It should be noted, however, that some overlap exists between them. Int J Occup Med Environ Health. 2019;32(1):75 – 85

5 Article Mitochondrial complex activity in permeabilised cells of chronic fatigue syndrome patients using two cell types. 2019

Tomas, Cara / Brown, Audrey E / Newton, Julia L / Elson, Joanna L. ·Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. · NHS Foundation Trust, Newcastle upon Tyne Hospitals, Newcastle upon Tyne, United Kingdom. · Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. · Centre for Human Metabonomics, North-West University, Potchefstroom, South Africa. ·PeerJ · Pubmed #30847260.

ABSTRACT: Abnormalities in mitochondrial function have previously been shown in chronic fatigue syndrome (CFS) patients, implying that mitochondrial dysfunction may contribute to the pathogenesis of disease. This study builds on previous work showing that mitochondrial respiratory parameters are impaired in whole cells from CFS patients by investigating the activity of individual mitochondrial respiratory chain complexes. Two different cell types were used in these studies in order to assess individual complex activity locally in the skeletal muscle (myotubes) (

6 Article A characterisation model to address the environmental impact of green water flows for water scarcity footprints. 2018

Quinteiro, Paula / Rafael, Sandra / Villanueva-Rey, Pedro / Ridoutt, Bradley / Lopes, Myriam / Arroja, Luís / Dias, Ana Cláudia. ·Centre for Environmental and Marine Studies (CESAM), Department of Environment and Planning, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. Electronic address: p.sofia@ua.pt. · Centre for Environmental and Marine Studies (CESAM), Department of Environment and Planning, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. Electronic address: sandra.rafel@ua.pt. · Centre for Environmental and Marine Studies (CESAM), Department of Environment and Planning, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal; Department of Chemical Engineering, Institute of Technology, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, Galicia, Spain. Electronic address: pedro.villanueva@usc.es. · University of the Free State, Department of Agricultural Economics, Bloemfontein 9300, South Africa; Commonwealth Scientific and Industrial Research Organisation (CSIRO), Private Bag 10, Clayton South, Victoria 3169, Australia. Electronic address: Brad.Ridoutt@csiro.au. · Centre for Environmental and Marine Studies (CESAM), Department of Environment and Planning, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. Electronic address: myr@ua.pt. · Centre for Environmental and Marine Studies (CESAM), Department of Environment and Planning, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. Electronic address: arroja@ua.pt. · Centre for Environmental and Marine Studies (CESAM), Department of Environment and Planning, University of Aveiro, Campus Universitário de Santiago, 3810-193 Aveiro, Portugal. Electronic address: acdias@ua.pt. ·Sci Total Environ · Pubmed #29898528.

ABSTRACT: The development of methods to assess the potential environmental impact of green water consumption in life cycle assessment has lagged behind those for blue water use, which are now routinely applied in industrial and policy-related studies. This represents a critical gap in the assessment of land-based production systems and the ability to inform policy related to the bio-economy. Combining satellite remote sensing and meteorological data sets, this study develops two new sets of spatially-differentiated and globally applicable characterisation factors (CFs) to assess the environmental impact of green water flows in LCA. One set of CFs addresses the impact of shifts in water vapour flow by evapotranspiration on blue water availability (CFWS) and the other set of CFs addresses moisture recycling within a basin (CFWA). Furthermore, as an additional and optional step, these two indicators are combined into an aggregated green water scarcity indicator, representing the global variability of green water scarcity. The values obtained for CFWA show that there are significant changes in green water flows that were returned to the atmosphere in Alaska (covered by open shrublands) and in some central regions of China (covered by grasslands and barren or sparsely vegetated land), where precipitation levels are lower than 10 mm/yr. The results obtained for CFWS indicate that severe perturbations in surface blue water production occur, particularly in central regions of China (covered by grasslands), the southeast of Australia (covered by evergreen broadleaf forest) and in some central regions of the USA (covered by grassland and evergreen needleleaf forest). The application of the green water scarcity CFs enables the evaluation of the potential environmental impact due to green water consumption by agricultural and forestry products, informing both technical and non-technical audiences and decision-makers for the purpose of strategic planning of land use and to identify green water protection measures.

7 Article Cellular bioenergetics is impaired in patients with chronic fatigue syndrome. 2017

Tomas, Cara / Brown, Audrey / Strassheim, Victoria / Elson, Joanna L / Newton, Julia / Manning, Philip. ·Institute of Cellular Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. · Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, United Kingdom. · Newcastle upon Tyne Hospitals, NHS Foundation Trust, Newcastle upon Tyne, United Kingdom. · Institute of Genetic Medicine, Newcastle University, Newcastle upon Tyne, United Kingdom. · Centre for Human Metabolomics, North-West University, Potchefstroom, South Africa. ·PLoS One · Pubmed #29065167.

ABSTRACT: Chronic fatigue syndrome (CFS) is a highly debilitating disease of unknown aetiology. Abnormalities in bioenergetic function have been cited as one possible cause for CFS. Preliminary studies were performed to investigate cellular bioenergetic abnormalities in CFS patients. A series of assays were conducted using peripheral blood mononuclear cells (PBMCs) from CFS patients and healthy controls. These experiments investigated cellular patterns in oxidative phosphorylation (OXPHOS) and glycolysis. Results showed consistently lower measures of OXPHOS parameters in PBMCs taken from CFS patients compared with healthy controls. Seven key parameters of OXPHOS were calculated: basal respiration, ATP production, proton leak, maximal respiration, reserve capacity, non-mitochondrial respiration, and coupling efficiency. While many of the parameters differed between the CFS and control cohorts, maximal respiration was determined to be the key parameter in mitochondrial function to differ between CFS and control PBMCs due to the consistency of its impairment in CFS patients found throughout the study (p≤0.003). The lower maximal respiration in CFS PBMCs suggests that when the cells experience physiological stress they are less able to elevate their respiration rate to compensate for the increase in stress and are unable to fulfil cellular energy demands. The metabolic differences discovered highlight the inability of CFS patient PBMCs to fulfil cellular energetic demands both under basal conditions and when mitochondria are stressed during periods of high metabolic demand.

8 Article Clinically proven mtDNA mutations are not common in those with chronic fatigue syndrome. 2017

Schoeman, Elizna M / Van Der Westhuizen, Francois H / Erasmus, Elardus / van Dyk, Etresia / Knowles, Charlotte V Y / Al-Ali, Shereen / Ng, Wan-Fai / Taylor, Robert W / Newton, Julia L / Elson, Joanna L. ·Centre for Human Metabolomics, North-West University, Potchefstroom, South Africa. · Wellcome Trust Centre for Mitochondrial Research, Institute of Neuroscience, The Medical School, Newcastle University, Newcastle upon Tyne, NE2 4HH, UK. · Institute of Cellular Medicine, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK. · Department of Biology, College of Science, University of Basrah, Basrah, Iraq. · Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne, UK. · Centre for Human Metabolomics, North-West University, Potchefstroom, South Africa. Joanna.elson@ncl.ac.uk. · Institute of Genetic Medicine, Newcastle University, Central Parkway, Newcastle upon Tyne, UK. Joanna.elson@ncl.ac.uk. ·BMC Med Genet · Pubmed #28302057.

ABSTRACT: BACKGROUND: Chronic Fatigue Syndrome (CFS) is a prevalent debilitating condition that affects approximately 250,000 people in the UK. There is growing interest in the role of mitochondrial function and mitochondrial DNA (mtDNA) variation in CFS. It is now known that fatigue is common and often severe in patients with mitochondrial disease irrespective of their age, gender or mtDNA genotype. More recently, it has been suggested that some CFS patients harbour clinically proven mtDNA mutations. METHODS: MtDNA sequencing of 93 CFS patients from the United Kingdom (UK) and South Africa (RSA) was performed using an Ion Torrent Personal Genome Machine. The sequence data was examined for any evidence of clinically proven mutations, currently; more than 200 clinically proven mtDNA mutations point mutations have been identified. RESULTS: We report the complete mtDNA sequence of 93 CFS patients from the UK and RSA, without finding evidence of clinically proven mtDNA mutations. This finding demonstrates that clinically proven mtDNA mutations are not a common element in the aetiology of disease in CFS patients. That is patients having a clinically proven mtDNA mutation and subsequently being misdiagnosed with CFS are likely to be rare. CONCLUSION: The work supports the assertion that CFS should not be considered to fall within the spectrum of mtDNA disease. However, the current study cannot exclude a role for nuclear genes with a mitochondrial function, nor a role of mtDNA population variants in susceptibility to disease. This study highlights the need for more to be done to understand the pathophysiology of CFS.

9 Article Meningitis: is a major cause of disability amongst Papua New Guinea children? 2012

Karthikeyan, Priya / Ramalingam, Karthikeyan P. ·Department of Physiotherapy, Divine Word University, Madang, Papua New Guinea. pkarthi@dwu.ac.pg ·Disabil Rehabil · Pubmed #22256779.

ABSTRACT: PURPOSE: This article is intended to focus on the need for the use of rehabilitation services, for children with meningitis in Papua New Guinea, which is one of largest developing country in The Pacific with diverse culture and landscape. Meningitis is the fifth leading disease that results in disability in the country. The first line of treatment is usually antibiotics, administration of vaccination is also recommended. Currently community based rehabilitation workers and Physiotherapist offer the rehabilitation services. There is a need for the other rehabilitation professionals and appropriate education to the CBR workers, caregivers for providing effective Rehabilitation. METHOD: Articles related to meningitis were recruited through various electronic database such as Ovid SP, MEDLINE, CINHAL, Google Scholar and HINARI and EBSCOhost for full text. The search includes journal articles, editorials, research reports, systematic reviews and books. RESULTS: The neurological sequelae resulting from meningitis are increasing. There is a need for Hib vaccination to reduce the rate of mortality. Physiotherapists are new professionals that emerged since 2006 and are assisting in reducing the motor and neurological disability. CONCLUSIONS: A multidisciplinary approach is required to manage the child with meningitis. Adequate knowledge, resources and assistance about the condition among the health professionals, carers and teachers would enable the children to achieve the quality of life.

10 Minor Authors' response (April 8, 2019) concerning the paper "The relationship between chronic fatigue syndrome, burnout, job satisfaction, social support and age among academics at a tertiary institution". 2019

Coetzee, Nicoleen / Maree, David Jacobus Francois / Smit, Byron Nel. ·University of Pretoria, Pretoria, South Africa (Department of Psychology). nicoleen.coetzee@up.ac.za. · University of Pretoria, Pretoria, South Africa (Department of Psychology). david.maree@up.ac.za. · University of Pretoria, Pretoria, South Africa (Department of Psychology). bnsmit@gmail.com. ·Int J Occup Med Environ Health · Pubmed #31112141.

ABSTRACT: -- No abstract --

11 Minor Is chronic fatigue syndrome truly associated with haplogroups or mtDNA single nucleotide polymorphisms? 2016

Finsterer, Josef / Zarrouk-Mahjoub, Sinda. ·Krankenanstalt Rudolfstiftung, Postfach 20, 1180, Vienna, Austria. fifigs1@yahoo.de. · Genomics Platform, Pasteur Institute of Tunis, Tunis, Tunisia. ·J Transl Med · Pubmed #27317438.

ABSTRACT: -- No abstract --