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Chronic Fatigue Syndrome: HELP
Articles from Merseyside
Based on 8 articles published since 2010

These are the 8 published articles about Fatigue Syndrome, Chronic that originated from Merseyside during 2010-2020.
+ Citations + Abstracts
1 Review Do evidence based interventions for chronic fatigue syndrome improve sleep? A systematic review and narrative synthesis. 2017

Russell, Charlotte / Kyle, Simon D / Wearden, Alison J. ·School of Psychological Sciences, University of Manchester, UK. Electronic address: Charlotte.Russell@rlbuht.nhs.uk. · Sleep and Circadian Neuroscience Institute (SCNi), Nuffield Department of Clinical Neurosciences, University of Oxford, UK. · School of Psychological Sciences, University of Manchester, UK. ·Sleep Med Rev · Pubmed #27524207.

ABSTRACT: Cognitive behavioural therapy (CBT) and graded exercise therapy (GET) are recommended evidence based treatments for chronic fatigue syndrome (CFS), with research supporting their effectiveness in reducing fatigue and functional impairment. However, little research has focussed on the effect of these treatments on sleep, despite high reported sleep disturbance in CFS. Using a narrative synthesis approach, we aimed to 1) systematically identify and summarise the current evidence for the effectiveness of CBT and GET in improving sleep; 2) consider factors influencing treatment effectiveness, including incorporation of sleep management techniques; and 3) consider the appropriateness of sleep outcome measures used within evaluations. Studies evaluating CBT and/or GET for CFS, and including a sleep outcome were eligible for inclusion. Eight studies were identified. We found that GET interventions can improve sleep but this effect is inconsistent across studies. For CBT the evidence is limited with only one of two evaluations demonstrating sleep-related improvements. We conclude from existing research that we know little about the effects of including sleep management components within CBT and GET interventions. We suggest that future research should explore the effectiveness of sleep components within interventions, and sleep specific interventions, using comprehensive outcome measures that fully capture the range of sleep difficulties experienced in CFS.

2 Review Autoantibody pain. 2016

Goebel, Andreas. ·Pain Research Institute, Department of Translational Medicine, University of Liverpool, and The Walton Centre NHS Foundation Trust, Liverpool, L9 7AL, UK. Electronic address: andreasgoebel@rocketmail.com. ·Autoimmun Rev · Pubmed #26883460.

ABSTRACT: As autoantibodies bind to target tissues, Fc-region dependent inflammation can induce pain via mediators exciting nociceptors. But recently another possibility has emerged, where autoantibody binding to nociceptors can directly cause pain, without inflammation. This is thought to occur as a result of Fab-region mediated modification of nerve transduction, transmission, or neuropeptide release. In three conditions, complex regional pain syndrome, anti-voltage gated potassium channel complex autoimmunity, and chronic fatigue syndrome, all associated with no or only little inflammation, initial laboratory-, and clinical trial-results have suggested a potential role for autoantibody-mediated mechanisms. More research assessing the pathogenic roles of autoantibodies in these and other chronic pain conditions is required. The concept of autoantibody-mediated pain offers hope for the development of novel therapies for currently intractable pains.

3 Article Treating medically unexplained symptoms via improving access to psychological therapy (IAPT): major limitations identified. 2020

Geraghty, Keith / Scott, Michael J. ·Centre for Primary Care, Division of Health Sciences and Population Health, University of Manchester, Manchester, UK. Keith.geraghty@manchester.ac.uk. · , Liverpool, UK. ·BMC Psychol · Pubmed #32020880.

ABSTRACT: BACKGROUND: Improving Access to Psychological Therapies is a UK Government funded initiative to widen access to psychological treatment for a range of common mental health complaints, such as depression and anxiety. More recently, the service has begun to treat patients with medically unexplained symptoms. This paper reports on a review of treatment protocols and early treatment data for medically unexplained symptoms, specifically the illness myalgic encephalomyelitis/chronic fatigue syndrome. MAIN TEXT: A series of seven core problems and failings are identified, including an unproven treatment rationale, a weak and contested evidence-base, biases in treatment promotion, exaggeration of recovery claims, under-reporting of drop-out rates, and a significant risk of misdiagnosis and inappropriate treatment. CONCLUSIONS: There is a pressing need for independent oversight of this service, specifically evaluation of service performance and methods used to collect and report treatment outcomes. This service offers uniform psycho-behavioural therapy that may not meet the needs of many patients with medically unexplained health complaints. Psychotherapy should not become a default when patients' physical symptoms remain unexplained, and patients should be fully informed of the rationale behind psychotherapy, before agreeing to take part. Patients who reject psychotherapy or do not meet selection criteria should be offered appropriate medical and psychological support.

4 Article Service based comparison of group cognitive behavior therapy to waiting list control for chronic fatigue syndrome with regard to symptom reduction and positive psychological dimensions. 2019

Heald, Adrian / Barber, Louise / Jones, Helen Lyon / Farman, Sanam / Walther, Andreas. ·Department of Endocrinology. · Department of Clinical Psychology, Salford Royal NHS Foundation Trust, University of Manchester, Salford. · Mersey Deanery Psychiatry Rotation, Liverpool, UK. · Biological Psychology, TU Dresden, Dresden, Germany. ·Medicine (Baltimore) · Pubmed #31574792.

ABSTRACT: BACKGROUND: Although chronic fatigue syndrome (CFS) sometimes referred to as myalgic encephalomyelitis (ME) is a very challenging condition to treat, there is evidence that individual cognitive behavioral therapy (ICBT) can be effective for treatment and management of its symptoms. Furthermore, group cognitive behavioral therapy (GCBT) is emerging as promising treatment for the condition.The aim of the present study was to explore further the effectiveness of GCBT in a routine clinical setting and to investigate associated positive psychological effects related to GCBT. METHODS: In this pragmatic, non-randomized, controlled trial, 28 people acted as their own waiting list control by completing a range of measures 8 weeks prior to taking part in the GCBT. The intervention consisted of 8 consecutive weeks of 2.5-hour sessions. RESULTS: Repeated measures analysis of covariance revealed significant improvements in physical fatigue (F = 28.31, P < .01, effect size d = 0.52), mental fatigue (F = 7.72, P < .01, effect size d = 0.22), and depressive symptoms (Beck depression inventory-fast screen for medical individuals [BDI-FS]: F = 11.43, P < .01, effect size d = 0.30; hospital anxiety and depression scale [HADS-D]: F = 16.72, P < .01, effect size d = 0.38) compared with the waiting list. Improvements in quality of life (F = 7.56, P < .01, effect size d = 0.23), hope (F = 15.15, P < .01, effect size d = 0.36), and optimism (F = 8.17, P < .01, effect size d = 0.23) were also identified, but no change was reported for anxiety levels. Global outcome measures revealed that the majority of the individuals found the treatment beneficial and were satisfied with the results. CONCLUSION: GCBT is a beneficial and cost-effective treatment that individuals find amenable in routine clinical practice for CFS. Additionally we have described important effects emerged on positive psychological dimensions such as hope and optimism potentially enhancing the overall benefit.

5 Article Vitamin D status in chronic fatigue syndrome/myalgic encephalomyelitis: a cohort study from the North-West of England. 2017

Earl, Kate E / Sakellariou, Giorgos K / Sinclair, Melanie / Fenech, Manuel / Croden, Fiona / Owens, Daniel J / Tang, Jonathan / Miller, Alastair / Lawton, Clare / Dye, Louise / Close, Graeme L / Fraser, William D / McArdle, Anne / Beadsworth, Michael B J. ·Department of Musculoskeletal Biology, Institute of Ageing and Chronic Disease, MRC-Arthritis Research UK Centre for Integrated Research into Musculoskeletal Ageing, University of Liverpool, Liverpool, UK. · GeneFirst Ltd, Culham Science Centre, Oxfordshire, UK. · Tropical and Infectious Disease Unit, Royal Liverpool University Hospital, Liverpool, UK. · Human Appetite Research Unit, School of Psychology, University of Leeds, Leeds, UK. · Research Institute for Sport and Exercise Science, Liverpool John Moores University, Liverpool, UK. · Department of Medicine, Norwich Medical School, Faculty of Medicine and Health Sciences, University of East Anglia, Norwich Research Park, Norwich, UK. ·BMJ Open · Pubmed #29118054.

ABSTRACT: OBJECTIVE: Severe vitamin D deficiency is a recognised cause of skeletal muscle fatigue and myopathy. The aim of this study was to examine whether chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is associated with altered circulating vitamin D metabolites. DESIGN: Cohort study. SETTING: UK university hospital, recruiting from April 2014 to April 2015. PARTICIPANTS: Ninety-two patients with CFS/ME and 94 age-matched healthy controls (HCs). MAIN OUTCOME MEASURES: The presence of a significant association between CFS/ME, fatigue and vitamin D measures. RESULTS: No evidence of a deficiency in serum total 25(OH) vitamin D (25(OH)D CONCLUSIONS: Low serum concentrations of total 25(OH)D do not appear to be a contributing factor to the level of fatigue of CFS/ME.

6 Article Therapist Effects and the Impact of Early Therapeutic Alliance on Symptomatic Outcome in Chronic Fatigue Syndrome. 2015

Goldsmith, Lucy P / Dunn, Graham / Bentall, Richard P / Lewis, Shôn W / Wearden, Alison J. ·Centre for Biostatistics, Institute of Population Health, University of Manchester, Manchester, United Kingdom. · Manchester Academic Health Science Centre, Manchester, United Kingdom. · School of Health and Human Sciences, University of Huddersfield, Huddersfield, United Kingdom. · Institute of Psychology, Health and Society, University of Liverpool, Liverpool, United Kingdom. · Institute of Brain, Behaviour and Mental Health, University of Manchester, Manchester, United Kingdom. · School of Psychological Sciences and Manchester Centre for Health Psychology, University of Manchester, Manchester, United Kingdom. ·PLoS One · Pubmed #26657793.


7 Article Lyme disease in a British referral clinic. 2012

Cottle, L E / Mekonnen, E / Beadsworth, M B J / Miller, A R O / Beeching, N J. ·Tropical and Infectious Disease Unit, Royal Liverpool University Hospital, Prescot Street, Liverpool L7 8XP, UK. ·QJM · Pubmed #22301822.

ABSTRACT: BACKGROUND: Concerns about over-diagnosis and inappropriate management of Lyme disease (LD) are well documented in North America and supported by clinical data. There are few parallel data on the situation in the UK. AIM: To describe the patterns of referral, investigation, diagnosis and treatment of patients with suspected LD referred to an infectious disease unit in Liverpool, UK. Previous management by National Health Service (NHS) and non-NHS practitioners was reviewed. DESIGN: Descriptive study conducted by retrospective casenotes review. METHODS: Retrospective casenotes review of adults referred with possible LD to an infectious disease unit in Liverpool, UK, over 5 years (2006-2010). RESULTS: Of 115 patients, 27 (23%) were diagnosed with LD, 38 (33%) with chronic fatigue syndrome (CFS) and 13 (11%) with other medical conditions. No specific diagnosis could be made in 38 (33%). At least 53 unnecessary antibiotic courses had been given by non-NHS practitioners; 21 unnecessary courses had been prescribed by NHS practitioners. Among 38 patients, 17 (45%) with CFS had been misdiagnosed as having LD by non-NHS practitioners. CONCLUSION: A minority of referred patients had LD, while a third had CFS. LD is over-diagnosed by non-specialists, reflecting the complexities of clinical and/or laboratory diagnosis. Patients with CFS were susceptible to misdiagnosis in non-NHS settings, reinforcing concerns about missed opportunities for appropriate treatment for this group and about the use of inappropriate diagnostic modalities and anti-microbials in non-NHS settings.

8 Minor Graded exercise self-help for chronic fatigue syndrome in GETSET. 2018

Crawford, Joan S. ·The Brain Charity, Liverpool, UK; Chester MESH (ME Self-Help), Chester, CH2 2AN, UK; Chronic Pain Management Service, St Helens Hospital, St Helens, UK. Electronic address: joan.crawford1@outlook.com. ·Lancet · Pubmed #29595492.

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