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Chronic Fatigue Syndrome: HELP
Articles from North Carolina
Based on 12 articles published since 2010

These are the 12 published articles about Fatigue Syndrome, Chronic that originated from North Carolina during 2010-2020.
+ Citations + Abstracts
1 Review A systematic review of the association between fatigue and genetic polymorphisms. 2017

Wang, Tengteng / Yin, Jie / Miller, Andrew H / Xiao, Canhua. ·Department of Epidemiology, University of North Carolina at Chapel Hill Gillings School of Global Public Health, Chapel Hill, NC, United States; Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, United States. · Department of Epidemiology, Emory University Rollins School of Public Health, Atlanta, GA, United States; Kaiser Permanente Northern California, Division of Research, Oakland, CA, United States. · Department of Psychiatry and Behavioral Sciences, School of Medicine, Emory University, Atlanta, GA, United States. · School of Nursing, Emory University, Atlanta, GA, United States. Electronic address: canhua.xiao@emory.edu. ·Brain Behav Immun · Pubmed #28089639.

ABSTRACT: Fatigue is one of the most common and distressing symptoms, leading to markedly decreased quality of life among a large subset of patients with a variety of disorders. Susceptibility to fatigue may be influenced by genetic factors including single nucleotide polymorphisms (SNPs), especially in the regulatory regions, of relevant genes. To further investigate the association of SNPs with fatigue in various patient populations, a systematic search was conducted on Pubmed, CINAHL, PsycINFO, and Sociological Abstracts Database for fatigue related-terms in combination with polymorphisms or genetic variation-related terms. Fifty papers in total met the inclusion and exclusion criteria for this analysis. These 50 papers were further classified into three subgroups for evaluation: chronic fatigue syndrome (CFS), cancer-related fatigue (CRF) and other disease-related fatigue. SNPs in regulatory pathways of immune and neurotransmitter systems were found to play important roles in the etiologies of CFS, CRF and other disease-related fatigue. Evidence for associations between elevated fatigue and specific polymorphisms in TNFα, IL1b, IL4 and IL6 genes was revealed for all three subgroups of fatigue. We also found CFS shared a series of polymorphisms in HLA, IFN-γ, 5-HT and NR3C1 genes with other disease-related fatigue, however these SNPs (excluding IFN-γ) were not found to be adequately investigated in CRF. Gaps in knowledge related to fatigue etiology and recommendations for future research are further discussed.

2 Clinical Trial Tracking post-infectious fatigue in clinic using routine Lab tests. 2016

Harvey, Jeanna M / Broderick, Gordon / Bowie, Alanna / Barnes, Zachary M / Katz, Ben Z / O'Gorman, Maurice R G / Vernon, Suzanne D / Fletcher, Mary Ann / Klimas, Nancy G / Taylor, Renee. ·Department of Medicine, University of Miami, Miami, FL, USA. · Department of Medicine, University of Miami, Miami, FL, USA. gbroderick@nova.edu. · Institute for Neuro Immune Medicine, Nova Southeastern University, University Park Plaza, 3440 South University, Fort Lauderdale, 33328, FL, USA. gbroderick@nova.edu. · University of Alberta, Edmonton, AB, Canada. gbroderick@nova.edu. · University of Alberta, Edmonton, AB, Canada. · Ann & Robert H Lurie Children's Hospital of Chicago, Chicago, IL, USA. · Children's Hospital Los Angeles, Los Angeles, CA, USA. · Solve ME/CFS Initiative, Charlotte, NC, USA. · Institute for Neuro Immune Medicine, Nova Southeastern University, University Park Plaza, 3440 South University, Fort Lauderdale, 33328, FL, USA. · University of Illinois at Chicago, Chicago, IL, USA. ·BMC Pediatr · Pubmed #27118537.

ABSTRACT: BACKGROUND: While biomarkers for chronic fatigue syndrome (CFS) are beginning to emerge they typically require a highly specialized clinical laboratory. We hypothesized that subsets of commonly measured laboratory markers used in combination could support the diagnosis of post-infectious CFS (PI-CFS) in adolescents following infectious mononucleosis (IM) and help determine who might develop persistence of symptoms. METHODS: Routine clinical laboratory markers were collected prospectively in 301 mono-spot positive adolescents, 4 % of whom developed CFS (n = 13). At 6, 12, and 24 months post-diagnosis with IM, 59 standard tests were performed including metabolic profiling, liver enzyme panel, hormone profiles, complete blood count (CBC), differential white blood count (WBC), salivary cortisol, and urinalysis. Classification models separating PI-CFS from controls were constructed at each time point using stepwise subset selection. RESULTS: Lower ACTH levels at 6 months post-IM diagnosis were highly predictive of CFS (AUC p = 0.02). ACTH levels in CFS overlapped with healthy controls at 12 months, but again showed a trend towards a deficiency at 24 months. Conversely, estradiol levels depart significantly from normal at 12 months only to recover at 24 months (AUC p = 0.02). Finally, relative neutrophil count showed a significant departure from normal at 24 months in CFS (AUC p = 0.01). Expression of these markers evolved differently over time between groups. CONCLUSIONS: Preliminary results suggest that serial assessment of stress and sex hormones as well as the relative proportion of innate immune cells measured using standard clinical laboratory tests may support the diagnosis of PI-CFS in adolescents with IM.

3 Article Angiotensin-II-Evoked Ca 2020

Camacho Londoño, Juan E / Marx, André / Kraft, Axel E / Schürger, Alexander / Richter, Christin / Dietrich, Alexander / Lipp, Peter / Birnbaumer, Lutz / Freichel, Marc. ·Pharmakologisches Institut, Ruprecht-Karls-Universität Heidelberg, INF 366, 69120 Heidelberg, Germany. · DZHK (German Centre for Cardiovascular Research), partner site Heidelberg/Mannheim, 69120, Germany. · Walther-Straub-Institut für Pharmakologie und Toxikologie, Ludwig-Maximilians-Universität, 80336 München, Germany. · Medical Faculty, Centre for Molecular Signalling (PZMS), Institute for Molecular Cell Biology and Research Center for Molecular Imaging and Screening, Saarland University, 66421 Homburg/Saar, Germany. · Laboratory of Neurobiology, NIEHS, North Carolina, USA and Institute of Biomedical Research (BIOMED), Catholic University of Argentina, Buenos Aires C1107AFF, Argentina. ·Cells · Pubmed #32013125.

ABSTRACT: TRPC proteins form cation conducting channels regulated by different stimuli and are regulators of the cellular calcium homeostasis. TRPC are expressed in cardiac cells including cardiac fibroblasts (CFs) and have been implicated in the development of pathological cardiac remodeling including fibrosis. Using Ca

4 Article Psychometric properties of the PROMIS 2019

Yang, Manshu / Keller, San / Lin, Jin-Mann S. ·Department of Psychology, University of Rhode Island, 142 Flagg Road, Kingston, RI, 02881, USA. myang@uri.edu. · American Institutes for Research, Chapel Hill, NC, USA. myang@uri.edu. · American Institutes for Research, Chapel Hill, NC, USA. · Centers for Disease Control and Prevention, Atlanta, GA, USA. ·Qual Life Res · Pubmed #31506915.

ABSTRACT: PURPOSE: To evaluate the psychometric properties of the Patient-Reported Outcome Measurement Information System® Fatigue Short Form 7a (PROMIS F-SF) among people with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). METHODS: Analyses were conducted using data from the Multi-Site Clinical Assessment of ME/CFS study, which recruited participants from seven ME/CFS specialty clinics across the US. Baseline and follow-up data from ME/CFS participants and healthy controls were used. Ceiling/Floor effects, internal consistency reliability, differential item functioning (DIF), known-groups validity, and responsiveness were examined. RESULTS: The final sample comprised 549 ME/CFS participants at baseline, 386 of whom also had follow-up. At baseline, the sample mean of PROMIS F-SF T-score was 68.6 (US general population mean T-score of 50 and standard deviation of 10). The PROMIS F-SF demonstrated good internal consistency reliability (Cronbach's α = 0.84) and minimal floor/ceiling effects. No DIF was detected by age or sex for any item. This instrument also showed good known-groups validity with medium-to-large effect sizes (η CONCLUSIONS: Study findings support the reliability and validity of PROMIS F-SF as a measure of fatigue for ME/CFS and lend support to the drug development tool submission for qualifying this measure to evaluate therapeutic effect in ME/CFS clinical trials.

5 Article Estimating Prevalence, Demographics, and Costs of ME/CFS Using Large Scale Medical Claims Data and Machine Learning. 2018

Valdez, Ashley R / Hancock, Elizabeth E / Adebayo, Seyi / Kiernicki, David J / Proskauer, Daniel / Attewell, John R / Bateman, Lucinda / DeMaria, Alfred / Lapp, Charles W / Rowe, Peter C / Proskauer, Charmian. ·Optum Enterprise Analytics, UnitedHealth Group, Minneapolis, MN, United States. · Optum Technology, UnitedHealth Group, Minneapolis, MN, United States. · Innovation, Research, and Development, UnitedHealth Group, Minneapolis, MN, United States. · Bateman Horne Center, Salt Lake City, UT, United States. · Bureau of Infectious Disease and Laboratory Sciences, Massachusetts Department of Public Health, Boston, MA, United States. · Hunter-Hopkins Center, Charlotte, NC, United States. · Children's Center Chronic Fatigue Clinic, Johns Hopkins University School of Medicine, Baltimore, MD, United States. · Massachusetts ME/CFS & FM Association, Quincy, MA, United States. ·Front Pediatr · Pubmed #30671425.

ABSTRACT: Techniques of data mining and machine learning were applied to a large database of medical and facility claims from commercially insured patients to determine the prevalence, gender demographics, and costs for individuals with provider-assigned diagnosis codes for myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS). The frequency of diagnosis was 519-1,038/100,000 with the relative risk of females being diagnosed with ME or CFS compared to males 1.238 and 1.178, respectively. While the percentage of women diagnosed with ME/CFS is higher than the percentage of men, ME/CFS is not a "women's disease." Thirty-five to forty percent of diagnosed patients are men. Extrapolating from this frequency of diagnosis and based on the estimated 2017 population of the United States, a rough estimate for the number of patients who may be diagnosed with ME or CFS in the U.S. is 1.7 million to 3.38 million. Patients diagnosed with CFS appear to represent a more heterogeneous group than those diagnosed with ME. A machine learning model based on characteristics of individuals diagnosed with ME was developed and applied, resulting in a predicted prevalence of 857/100,000 (

6 Article Persistent neuropsychiatric impairment in HCV patients despite clearance of the virus?! 2017

Dirks, M / Pflugrad, H / Haag, K / Tillmann, H L / Wedemeyer, H / Arvanitis, D / Hecker, H / Tountopoulou, A / Goldbecker, A / Worthmann, H / Weissenborn, K. ·Department of Neurology, Hannover Medical School, Hannover, Germany. · Division of Gastroenterology, Hepatology & Nutrition, East Carolina University, Greenville, NC, USA. · Department of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, Hannover, Germany. · Department of Biometrics, Hannover Medical School, Hannover, Germany. ·J Viral Hepat · Pubmed #28117537.

ABSTRACT: One of the most disabling symptoms of hepatitis C virus (HCV) infection is chronic fatigue. While this is accepted for HCV polymerase chain reaction (PCR)-positive patients, a relationship between HCV infection and chronic fatigue is questioned after successful virus eradication. As fatigue is a subjective criterion, we aimed to evaluate in addition mood alterations and cognitive function in HCV-exposed patients with only mild liver disease and to assess a) possible interrelationships between these factors and health-related quality of life and b) the impact of viremia and former interferon treatment. One hundred and fifty-nine anti-HCV-positive individuals without advanced liver disease answered health-related quality of life (HRQoL), fatigue and depression questionnaires and underwent a battery of attention and memory tests. Accompanying diseases which could distort the results of the study such as HIV co-infection or drug addiction were exclusion criteria. The patients were subdivided into four groups according to their viremia status and interferon treatment history. Patients' data were evaluated with respect to norms given in the respective test manuals and in addition compared to those of 33 age-matched healthy controls. Eighty-five per cent of the patients had chronic fatigue, 50-60% mild depression or anxiety, 45% memory deficits and 30% attention deficits, irrespective of their HCV viremia status or treatment history. HRQoL correlated negatively with chronic fatigue (P<.001), while cognitive deficits-especially memory function-were independent from fatigue and depression. HCV infection may cause long-standing cerebral dysfunction that significantly impairs HRQoL and may even persist after clearance of the virus.

7 Article High-sensitive C-Reactive Protein as a Marker for Inflammation in Irritable Bowel Syndrome. 2016

Hod, Keren / Ringel-Kulka, Tamar / Martin, Christopher F / Maharshak, Nitsan / Ringel, Yehuda. ·Departments of *Epidemiology and Preventive Medicine, School of Public Health §Gastroenterology and Liver Diseases, Tel Aviv Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel Departments of †Medicine, Division of Gastroenterology and Hepatology ‡Maternal and Child Health, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC. ·J Clin Gastroenterol · Pubmed #25930973.

ABSTRACT: BACKGROUND: Recent studies demonstrated low-grade inflammation in patients with irritable bowel syndrome (IBS). However, these studies have been relatively small and do not enable examination of this factor in different subtypes of IBS and the possibility of confounding effects of comorbidities that may be associated with inflammatory responses. GOALS: To investigate the association between high-sensitive C-reactive protein (hs-CRP) and the diagnosis of IBS, IBS subtypes, symptoms' severity, and IBS-associated comorbidities. STUDY: This cross-sectional study uses data from a large matched case-control study of IBS subjects and healthy controls (HC). hs-CRP levels were measured in all subjects. IBS diagnosis was determined by Rome III criteria, negative screening blood tests, and normal colonoscopy. Subjects were evaluated for IBS severity and associated pain and psychological comorbidities. RESULTS: A total of 242 IBS patients and 244 HC were studied. Median hs-CRP levels in the IBS group were significantly higher than in HC (1.80; interquartile range, 0.7 to 4.04 mg/L vs. 1.20, interquartile range, 0.5 to 2.97 mg/L respectively, P<0.006). Levels were highest in IBS-D patients with greater disease severity. Hs-CRP levels mildly correlated with symptoms severity (r=0.169, P=0.009); this correlation was stronger for the IBS-D patients (r=0.27, P=0.006). IBS was a significant independent predictor (P=0.025) for higher hs-CRP levels, whereas other pain and psychological comorbidities were not. CONCLUSIONS: Given these observations of cross-sectional differences in hs-CRP between IBS subtypes and severity, independent of pain and comorbidities, more research is needed to explore a possible role of low-grade inflammation in the pathogenesis and/or clinical presentation of IBS.

8 Article DNA methylation modifications associated with chronic fatigue syndrome. 2014

de Vega, Wilfred C / Vernon, Suzanne D / McGowan, Patrick O. ·Centre for Environmental Epigenetics and Development, University of Toronto, Scarborough, ON, Canada; Department of Biological Sciences, University of Toronto, Scarborough, ON, Canada; Department of Cell and Systems Biology, University of Toronto, Toronto, ON, Canada. · CFIDS Association of America, Charlotte, North Carolina, United States of America. ·PLoS One · Pubmed #25111603.

ABSTRACT: Chronic Fatigue Syndrome (CFS), also known as myalgic encephalomyelitis, is a complex multifactorial disease that is characterized by the persistent presence of fatigue and other particular symptoms for a minimum of 6 months. Symptoms fail to dissipate after sufficient rest and have major effects on the daily functioning of CFS sufferers. CFS is a multi-system disease with a heterogeneous patient population showing a wide variety of functional disabilities and its biological basis remains poorly understood. Stable alterations in gene function in the immune system have been reported in several studies of CFS. Epigenetic modifications have been implicated in long-term effects on gene function, however, to our knowledge, genome-wide epigenetic modifications associated with CFS have not been explored. We examined the DNA methylome in peripheral blood mononuclear cells isolated from CFS patients and healthy controls using the Illumina HumanMethylation450 BeadChip array, controlling for invariant probes and probes overlapping polymorphic sequences. Gene ontology (GO) and network analysis of differentially methylated genes was performed to determine potential biological pathways showing changes in DNA methylation in CFS. We found an increased abundance of differentially methylated genes related to the immune response, cellular metabolism, and kinase activity. Genes associated with immune cell regulation, the largest coordinated enrichment of differentially methylated pathways, showed hypomethylation within promoters and other gene regulatory elements in CFS. These data are consistent with evidence of multisystem dysregulation in CFS and implicate the involvement of DNA modifications in CFS pathology.

9 Article No association found between the detection of either xenotropic murine leukemia virus-related virus or polytropic murine leukemia virus and chronic fatigue syndrome in a blinded, multi-site, prospective study by the establishment and use of the SolveCFS BioBank. 2014

Irlbeck, David M / Vernon, Suzanne D / McCleary, K Kimberly / Bateman, Lucinda / Klimas, Nancy G / Lapp, Charles W / Peterson, Daniel L / Brown, James R / Remlinger, Katja S / Wilfret, David A / Gerondelis, Peter. ·Division of Infectious Diseases, GlaxoSmithKline, Research Triangle Park, NC, USA. peter.z.gerondelis@gsk.com. ·BMC Res Notes · Pubmed #25092471.

ABSTRACT: BACKGROUND: In 2009, a retrospective study reported the detection of xenotropic murine leukemia virus-related virus (XMRV) in clinical isolates derived from individuals with chronic fatigue syndrome or myalgic encephalomyelitis (CFS). While many efforts to confirm this observation failed, one report detected polytropic murine leukemia virus (pMLV), instead of XMRV. In both studies, Polymerase Chain Reaction (PCR)-based methods were employed which could provide the basis for the development of a practical diagnostic tool. To confirm these studies, we hypothesized that the ability to detect these viruses will not only depend upon the technical details of the methods employed but also on the criteria used to diagnose CFS and the availability of well characterized clinical isolates. METHODS: A repository of clinical isolates from geographically distinct sites was generated by the collection of fresh blood samples from well characterized CFS and healthy subjects. Molecular techniques were used to generate assay positive controls and to determine the lower limit of detection (LLOD) for murine retroviral and Intracisternal A particle (Cell 12(4):963-72, 1977) detection methods. RESULTS: We report the establishment of a repository of well-defined, clinical isolates from five, geographically distinct regions of the US, the comparative determination of the LLODs and validation efforts for the previously reported detection methods and the results of an effort to confirm the association of these retroviral signatures in isolates from individuals with CFS in a blinded, multi-site, prospective study. We detected various, murine retroviral DNA signatures but were unable to resolve a difference in the incidence of their detection between isolates from CFS (5/72; 6.7%) and healthy (2/37; 5.4%) subjects (Fisher's Exact Test, p-value = 1). The observed sequences appeared to reflect the detection of endogenous murine retroviral DNA, which was not identical to either XMRV or pMLV. CONCLUSIONS: We were unable to confirm a previously reported association between the detection of XMRV or pMLV sequences and CFS in a prospective, multi-site study. Murine retroviral sequences were detected at a low frequency that did not differ between CFS and control subjects. The nature of these sequences appeared to reflect the detection of pre-existing, endogenous, murine retroviral DNA in the PCR reagents employed.

10 Article Method Issues in Epidemiological Studies of Medically Unexplained Symptom-based Conditions in Veterans. 2013

Coughlin, Steven S / McNeil, Rebecca B / Provenzale, Dawn T / Dursa, Erin K / Thomas, Catherine M. ·Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, GA. · Durham Epidemiologic Research and Information Center, Veterans Affairs Medical Center, Durham, NC. · Durham Epidemiologic Research and Information Center, Veterans Affairs Medical Center, Durham, NC ; Division of Gastroenterology, Duke University Medical Center, Durham, NC. · Epidemiology Program, Post-deployment Health Group, Office of Public Health, Department of Veterans Affairs, Washington, DC. ·J Mil Veterans Health · Pubmed #24683425.

ABSTRACT: Symptom-based conditions such as chronic fatigue syndrome (CFS) and medically unexplained multi-symptom illness (MSI) are fairly common in the general population and are also important veteran's health concerns due to their higher frequency among U.S. veterans who served during the 1990-1991 Gulf War. CFS, MSI, and other symptom-based conditions are often associated with considerable morbidity due to fatigue, chronic pain, neurologic symptoms, and other symptoms that can impair the quality of life. This article discusses several important issues of methodology that arise in population studies of CFS and MSI. These include the exclusion criteria that have been used in population studies to define CFS-like illness and unexplained MSI, the potential for false positive and false negative assessments of illness status, the potential for sex differences, and the poorly understood natural history of these symptom-based conditions across the life span. As an empirical example of these methodology issues, we examined existing data from a 2005 follow-up survey. We found that 64.9% (762 of 1,175) of female Gulf War veterans and 53.4% (2,530 of 4,739) of male Gulf War veterans had 1 or more exclusionary medical conditions. The prevalence among veterans with one or more exclusionary medical conditions increased markedly by age among females and those with a low income.

11 Article An unbiased metagenomic search for infectious agents using monozygotic twins discordant for chronic fatigue. 2011

Sullivan, Patrick F / Allander, Tobias / Lysholm, Fredrik / Goh, Shan / Persson, Bengt / Jacks, Andreas / Evengård, Birgitta / Pedersen, Nancy L / Andersson, Björn. ·Department of Genetics, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA. pfsulliv@med.unc.edu ·BMC Microbiol · Pubmed #21194495.

ABSTRACT: BACKGROUND: Chronic fatigue syndrome is an idiopathic syndrome widely suspected of having an infectious or immune etiology. We applied an unbiased metagenomic approach to try to identify known or novel infectious agents in the serum of 45 cases with chronic fatigue syndrome or idiopathic chronic fatigue. Controls were the unaffected monozygotic co-twins of cases, and serum samples were obtained at the same place and time. RESULTS: No novel DNA or RNA viral signatures were confidently identified. Four affected twins and no unaffected twins evidenced viremia with GB virus C (8.9% vs. 0%, p = 0.019), and one affected twin had previously undetected hepatitis C viremia. An excess of GB virus C viremia in cases with chronic fatigue requires confirmation. CONCLUSIONS: Current, impairing chronic fatigue was not robustly associated with viremia detectable in serum.

12 Article An investigation of victimization and the clinical course of chronic fatigue syndrome. 2010

Johnson, Susan K / Schmaling, Karen B / Dmochowski, Jacek / Bernstein, David. ·University of North Carolina at Charlotte, 9201 University City Blvd, Charlotte, NC 28223, USA. skjohnso@uncc.edu ·J Health Psychol · Pubmed #20348356.

ABSTRACT: Medically unexplained syndromes, including chronic fatigue syndrome (CFS), have been associated with victimization in childhood and adulthood. The purpose of this study was to examine the associations of victimization experiences in childhood and adulthood with functional status and illness severity in a sample of patients with CFS using longitudinal data. In the sample of 93 patients with CFS, childhood abuse and neglect had greater impact than adulthood victimization. Overall, victimization experiences in childhood demonstrated modest associations with clinical outcomes in CFS, although several victimization experiences were in the opposite direction of expectations. Victimization predicted worse outcomes, but not worsening outcomes over time.