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Corneal Ulcer HELP
Based on 1,365 articles published since 2010

These are the 1365 published articles about Corneal Ulcer that originated from Worldwide during 2010-2020.
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14 · 15 · 16 · 17 · 18 · 19 · 20
1 Editorial Fungal keratitis: dealing with a diverse kingdom of ocular assailants. 2016

McGhee, Charles Nj / Kim, Bia Z. ·Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand. ·Clin Exp Ophthalmol · Pubmed #28001007.

ABSTRACT: -- No abstract --

2 Editorial Treating Infectious Keratitis. 2016

Cunningham, Emmett T / Acharya, Nisha R / Akpek, Esen K / Zierhut, Manfred. ·a Department of Ophthalmology , California Pacific Medical Center , San Francisco , California , USA . · b The Department of Ophthalmology , Stanford University School of Medicine , Stanford , California , USA . · c The Francis I. Proctor Foundation, University of California San Francisco , San Francisco , California , USA . · d Ocular Surface Diseases and Dry Eye Clinic, Wilmer Eye Institute, Johns Hopkins University School of Medicine , Baltimore , Maryland , USA , and. · e Centre for Ophthalmology, University Tuebingen , Tuebingen , Germany. ·Ocul Immunol Inflamm · Pubmed #27681115.

ABSTRACT: -- No abstract --

3 Editorial Seeing red: over-the-counter chloramphenicol. 2015

Robaei, Dana / Naunton, Mark / Watson, Stephanie. ·Save Sight Institute, University of Sydney, Sydney, New South Wales, Australia; Department of Ophthalmology, Westmead Hospital, Sydney, New South Wales, Australia. ·Clin Exp Ophthalmol · Pubmed #25833086.

ABSTRACT: -- No abstract --

4 Editorial PACK-CXL: defining CXL for infectious keratitis. 2014

Hafezi, Farhad / Randleman, J Bradley. · ·J Refract Surg · Pubmed #24983827.

ABSTRACT: -- No abstract --

5 Editorial Immunotherapy for corneal inflammatory disorders: stepping up and down the ladder. 2013

Saw, Valerie P J. · ·Br J Ophthalmol · Pubmed #24141142.

ABSTRACT: -- No abstract --

6 Editorial Corticosteroids for bacterial keratitis: who gets them? 2013

Jones, Dan B. · ·JAMA Ophthalmol · Pubmed #23411890.

ABSTRACT: -- No abstract --

7 Editorial The corneal melting point. 2012

Hossain, P. · ·Eye (Lond) · Pubmed #22766538.

ABSTRACT: -- No abstract --

8 Editorial The changing spectrum of microbial keratitis: is microsporia increasing as a cause of microbial keratitis or is it a previously unrecognised cause? 2012

Schwab, Ivan R. · ·Br J Ophthalmol · Pubmed #22457272.

ABSTRACT: -- No abstract --

9 Editorial The challenge of fungal keratitis. 2011

Said, Dalia G / Otri, Muneer / Miri, Ammar / Kailasanathan, Anusha / Khatib, Tasneem / Dua, Harminder S. · ·Br J Ophthalmol · Pubmed #22096205.

ABSTRACT: -- No abstract --

10 Editorial Mooren's ulcer and amniotic membrane transplant: a simple surgical solution? 2011

McGhee, Charles N J / Patel, Dipika V. · ·Clin Exp Ophthalmol · Pubmed #21749593.

ABSTRACT: -- No abstract --

11 Editorial Challenges in the management of corneal ulcer. 2011

Singh, S K. · ·Nepal J Ophthalmol · Pubmed #21505538.

ABSTRACT: -- No abstract --

12 Editorial Orlans HO, Hornby SJ, Bowler IC (2011) In vitro antibiotic susceptibility patterns of bacterial keratitis isolates in Oxford, UK: a 10-year review. Eye Jan 21 [Epub ahead of print] PMID 21252952. 2011

Kaye, Stephen / Gilbert, Rose / Sueke, Henri / Neal, Timothy. · ·Graefes Arch Clin Exp Ophthalmol · Pubmed #21445628.

ABSTRACT: -- No abstract --

13 Editorial Diagnosis of microbial keratitis. 2010

Garg, P. · ·Br J Ophthalmol · Pubmed #20679086.

ABSTRACT: -- No abstract --

14 Review Amniotic membrane transplantation for managing dry eye and neurotrophic keratitis. 2020

Mead, Olivia G / Tighe, Sean / Tseng, Scheffer C G. ·R&D Department, TissueTech Inc., Miami, FL, USA. · Department of Ophthalmology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. · Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, Miami, FL, USA. · Ocular Surface Center, Miami, FL, USA. ·Taiwan J Ophthalmol · Pubmed #32309119.

ABSTRACT: Neurotrophic keratitis (NK), a degenerative disease caused by damage to the trigeminal nerve, abolishes both tearing and blinking reflexes, thus causing the most severe forms of dry eye disease (DED). Conversely, the increasing severity of DED also leads to progressive loss of corneal nerve density, potentially resulting in NK. Both diseases manifest the same spectrum of corneal pathologies including inflammation and corneal epithelial keratitis, which can progress into vision-threatening epithelial defect and stromal ulceration. This review summarizes the current literature regarding outcomes following sutured and sutureless cryopreserved amniotic membrane (AM) in treating DED as well as epithelial defects and corneal ulcers due to underlying NK. These studies collectively support the safety and effectiveness of cryopreserved AM in restoring corneal epithelial health, improving visual acuity in eyes with NK and DED, and alleviating symptomatic DED. Future randomized controlled trials are warranted to validate the above findings and determine whether such clinical efficacy lies in promoting corneal nerve regeneration.

15 Review Etiology and Risk Factors for Infectious Keratitis in South Texas. 2020

Puig, Madeleine / Weiss, Menachem / Salinas, Ricardo / Johnson, Daniel A / Kheirkhah, Ahmad. ·Department of Ophthalmology, Long School of Medicine, University of Texas Health at San Antonio, San Antonio, Texas, USA. ·J Ophthalmic Vis Res · Pubmed #32308946.

ABSTRACT: Purpose: To determine the causative organisms and associated risk factors for infectious keratitis in South Texas. Methods: This retrospective study was performed at a tertiary teaching hospital system in South Texas. Medical records of all patients who presented with infectious keratitis from 2012 to 2018 were reviewed. Only patients with culture-proven bacterial, fungal, and Results: In total, 182 eyes of 181 patients had culture-proven bacterial, fungal, or Conclusions: Bacteria are the most common cause of infectious keratitis in this patient population, with coagulase-negative

16 Review Fulminant 2019

Agarwal, Rinky / Gagrani, Meghal / Mahajan, Asmita / Sharma, Namrata. ·Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India rinky.1990@gmail.com. · Ophthalmology, Dr Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi, Delhi, India. ·BMJ Case Rep · Pubmed #31801779.


17 Review Challenges in the diagnosis of microbial keratitis: A detailed review with update and general guidelines. 2019

Alkatan, Hind M / Al-Essa, Rakan S. ·Department of Ophthalmology, College of Medicine, King Saud University-Medical City, Riyadh, Saudi Arabia. · Department of Pathology, College of Medicine, King Saud University-Medical City, Riyadh, Saudi Arabia. ·Saudi J Ophthalmol · Pubmed #31686969.

ABSTRACT: The incidence of microbial keratitis (MK) is variable worldwide with an estimated 1.5-2 million cases of corneal ulcers in developing countries. The complications of MK can be severe and vision threatening. Therefore, proper diagnosis of the causative organism is essential for early successful treatment. Accurate sampling of microbiological specimens in MK is an important step in identifying the infective organism. Corneal scrapping, tear samples and corneal biopsy are examples of specimens obtained for the investigative procedures in MK. Ophthalmologists especially in an emergency room setting should be aware of the proper sampling techniques based on their microbiology-related basic information for each category of MK. This review article briefly describes the clinical presentation and defines in details the best updated diagnostic methods used in different types of MK. It can be used as a guide for ophthalmology trainees and general ophthalmologists who may be handling such cases at initial presentation.

18 Review Biological Staining and Culturing in Infectious Keratitis: Controversy in Clinical Utility. 2019

Moshirfar, Majid / Hopping, Grant C / Vaidyanathan, Uma / Liu, Harry / Somani, Anisha N / Ronquillo, Yasmyne C / Hoopes, Phillip C. ·Hoopes Durrie Rivera Research Center, Hoopes Vision, Draper, UT, USA. · Utah Lions Eye Bank, Murray, UT, USA. · John A. Moran Eye Center, Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT, USA. · McGovern Medical School, University of Texas Health Science Center, Houston, TX, USA. ·Med Hypothesis Discov Innov Ophthalmol · Pubmed #31598516.

ABSTRACT: Infectious keratitis causes significant, financial burden and is only increasing in frequency with contact lens use. Despite this, no retrospective studies, prospective studies, or clinical trials have evaluated the diagnostic validity of clinical guidelines in cases of infectious keratitis. Currently, standard of care recommends that corneal samples be obtained for staining and culturing in select patients showing evidence of corneal ulceration. Ideally, diagnostic information from corneal sampling is thought to help guide therapeutic interventions, prevent disease progression, reduce antibiotic resistance, and decrease overall expenditures for the management and treatment of infectious keratitis. However, current staining and culturing methods are limited by poor sensitivity in non-bacterial cases (i.e. fungal, viral) and lengthy turnaround times, and these methods do not frequently change clinical decision making. Newer fluoroquinolones and broad-spectrum antibiotics resolve the vast majority of cases of infectious keratitis, rendering cultures less essential for management. We studied the clinical utility of obtaining corneal samples for culturing and staining and the need for future research to establish superior diagnostic guidelines for their use in infectious keratitis.

19 Review Recent innovations with drugs in clinical trials for neurotrophic keratitis and refractory corneal ulcers. 2019

Bremond-Gignac, Dominique / Daruich, Alejandra / Robert, Matthieu P / Chiambaretta, Frederic. ·Ophthalmology Department, University Hospital Necker-Enfants malades, Paris, France. · INSERM UMRS 1138, Team 17, From physiopathology of ocular diseases to clinical development, Université Sorbonne Paris Cité, Centre de Recherche des Cordeliers, Paris, France. · Ophthalmology Department, University Hospital Gabriel Monpied, Clermont-Ferrand, France. ·Expert Opin Investig Drugs · Pubmed #31596151.


20 Review None 2019

O'Callaghan, Richard / Caballero, Armando / Tang, Aihua / Bierdeman, Michael. ·Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA. · Department of Microbiology and Immunology, University of Mississippi Medical Center, Jackson, MS 39216, USA. acaballero@umc.edu. ·Microorganisms · Pubmed #31443433.


21 Review Photoactivated chromophore for infectious keratitis - Corneal cross-linking (PACK-CXL): A systematic review and meta-analysis. 2019

Ting, Darren Shu Jeng / Henein, Christin / Said, Dalia G / Dua, Harminder S. ·Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK; Department of Ophthalmology, Queen Medical Centre, Nottingham, UK. Electronic address: ting.darren@gmail.com. · Newcastle University, Newcastle Upon Tyne, UK; National Institute for Health Research (NIHR) Biomedical Research Centre at Moorfields Eye Hospital NHS Foundation Trust and UCL Institute of Ophthalmology, London, UK. · Academic Ophthalmology, Division of Clinical Neuroscience, School of Medicine, University of Nottingham, Nottingham, UK; Department of Ophthalmology, Queen Medical Centre, Nottingham, UK. ·Ocul Surf · Pubmed #31401338.

ABSTRACT: PURPOSE: To examine the efficacy of adjuvant photoactivated chromophore for infectious keratitis-corneal cross-linking (PACK-CXL) for the treatment of infectious keratitis (IK). METHODS: Electronic databases, including MEDLINE, EMBASE and Cochrane Central, were searched for articles related to PACK-CXL. All clinical studies, including randomized controlled trials (RCTs), non-randomized controlled studies, case series and case reports, were included. A meta-analysis was further performed when there were sufficient similarities in the included RCTs. Primary outcome measure was time to complete corneal healing and secondary outcome measures included size of epithelial defect and infiltrate, corrected-distance-visual-acuity (CDVA), and adverse events. RESULTS: Forty-six eligible studies (including four RCTs) with 435 patients were included. When compared to standard antimicrobial treatment (SAT) alone, adjuvant PACK-CXL resulted in shorter mean time to complete corneal healing (-7.44 days; 95% CI, -10.71 to -4.16) and quicker resolution of the infiltrate at 7 days (-5.49 mm CONCLUSIONS: Our study demonstrates that adjuvant PACK-CXL expedites the healing of IK when compared to SAT alone (low-quality evidence). Further adequately powered, high-quality RCTs are required to fully ascertain the therapeutic effect of PACK-CXL.

22 Review Update on surgical management of corneal ulceration and perforation. 2019

Stamate, Alina-Cristina / Tătaru, Călin Petru / Zemba, Mihail. ·Department of Ophthalmology, "Carol Davila" University of Medicine and Pharmacy, Bucharest, Romania. · Arena Med Clinic, Bucharest, Romania. · Clinical Hospital of Ophthalmologic Emergencies, Bucharest, Romania. · Department of Ophthalmology, "Dr. Carol Davila" Central Military Emergency University Hospital, Bucharest, Romania. ·Rom J Ophthalmol · Pubmed #31334396.

ABSTRACT: Corneal ulcerations are a medical emergency, and in recalcitrant cases, leading to perforation, a surgical ophthalmological emergency. The urgency of the treatment is dictated by the necessity of preventing complications that can lead to serious ocular morbidities. Medical treatment represents the first therapeutic approach and is a defining step in the further management of a patient with corneal ulceration. Multiple surgical strategies are available, but the option depends on the etiology and parameters of the ulceration: size, depth, and location.

23 Review Corneal cross-linking (CXL)-A clinical study to evaluate CXL as a treatment in comparison with medical treatment for ulcerative keratitis in horses. 2019

Hellander Edman, Anna / Ström, Lena / Ekesten, Björn. ·Department of Clinical Sciences, Swedish University of Agricultural Sciences, Uppsala, Sweden. ·Vet Ophthalmol · Pubmed #31012258.

ABSTRACT: OBJECTIVE: Compare CXL treatment with medical treatment alone in horses with stromal, ulcerative keratitis. ANIMALS STUDIED: 24 horses (24 eyes) with stromal, ulcerative keratitis were included. PROCEDURE: 12 horses were initially treated with CXL, and 12 horses were given conventional medical treatment. Topical medical treatment was added to horses in the CXL group if necessary. Parameters including cytology, microbial growth, time to fluorescein negativity, and time to inhibition of stromal melting were evaluated. RESULTS: After the first day of treatments, a decrease in inflammatory signs and pain from the eye was observed in both groups. Stromal melting ceased within 24 hours regardless of treatment. CXL treatment alone was sufficient in 3 horses with noninfectious, superficial stromal ulcerations. Clinical signs of impaired wound healing were seen after 3-14 days in corneas with suspected or proven bacterial infection treated with CXL only, most likely because of insufficient elimination of bacteria deeper in the corneal stroma or because of re-infection from bacteria in the conjunctiva. The average decrease in stromal ulcer area per day after onset of treatment was almost identical between the groups, and no significant difference in time to fluorescein negativity was found. CONCLUSIONS: We consider CXL a possible useful adjunct treatment of corneal stromal ulcers in horses, especially for melting ulcers and as a potential alternative to prophylactic antibiotic treatment for noninfected stromal ulcers. However, CXL should not be used alone for infected or suspected infected stromal ulcers, because topical antibiotics were required in all horses with proven infectious keratitis.

24 Review Peripheral ulcerative keratitis with corneal melt as the primary presentation in a case of human immunodeficiency virus. 2019

Tavassoli, Shokufeh / Gunn, David / Tole, Derek / Darcy, Kieren. ·Cornea and Refractive Surgery, Bristol Eye Hospital, Bristol, UK. ·BMJ Case Rep · Pubmed #30798272.

ABSTRACT: Peripheral ulcerative keratitis (PUK) is an aggressive, potentially sight-threatening cause for peripheral corneal thinning. It is thought to be the result of immune complex deposition at the limbus, resulting in corneal inflammation and stromal melt. We present a case of a 43-year-old female patient of African origin, presenting with PUK and associated corneal perforation as the primary presentation of HIV infection. An urgent tectonic deep anterior lamellar keratoplasty was performed under general anaesthesia with excellent outcome. The patient was referred to the sexual health clinic and anti-retroviral treatment was initiated. This case is to the best of our knowledge the first report from the UK of PUK with corneal perforation as the primary presentation of HIV infection. As highlighted in this report, infection with HIV may initially be silent; therefore, it is vital to consider HIV infection when dealing with PUK of unknown aetiology.

25 Review Ocular infection caused by Hormographiella aspergillata: A case report and review of literature. 2019

Jain, N / Jinagal, J / Kaur, H / Ghosh, A / Gupta, S / Ram, J / Rudramurthy, S M. ·Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. · Department of Ophthalmology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. · Department of Medical Microbiology, Post Graduate Institute of Medical Education and Research, Chandigarh, India. Electronic address: drharsimranpgi@gmail.com. ·J Mycol Med · Pubmed #30630667.

ABSTRACT: Hormographiella aspergillata, a basidiomycete is a rare cause of human infection. We report a case of 70-year-old female with corneal ulcer and endophthalmitis caused by this agent. The patient had an intraocular implantation of lens following a cataract surgery. Corneal tissue obtained during therapeutic penetrating keratoplasty showed presence of septate hyphae on microscopy and culture grew H. aspergillata which was confirmed by sequencing of ITS region. Patient was started on systemic voriconazole and topical natamycin, however the eye could not be salvaged. To our knowledge, this is the first report of ocular infection caused Hormographiella aspergillata in an immunocompetent patient.