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Coronary Artery Disease: HELP
Articles by Ahmad Al-Sarraf
Based on 4 articles published since 2010
(Why 4 articles?)

Between 2010 and 2020, Ahmad Al-Sarraf wrote the following 4 articles about Coronary Artery Disease.
+ Citations + Abstracts
1 Review Regional and national familial hypercholesterolemia registries: present international application, importance, and needs for Canada. 2013

Al-Sarraf, Ahmad / Allard, Matt / Martinka, Michal / Frohlich, Jiri. ·Healthy Heart Program Prevention Clinic, St Paul's Hospital/Providence Health Care, Vancouver, British Columbia, Canada. ·Can J Cardiol · Pubmed #22717249.

ABSTRACT: -- No abstract --

2 Review Cardiovascular risk and atherosclerosis prevention. 2013

Frohlich, Jiri / Al-Sarraf, Ahmad. ·Healthy Heart Program Prevention Clinic, St Paul's Hospital, Vancouver, BC. jifr@mail.ubc.ca ·Cardiovasc Pathol · Pubmed #22502868.

ABSTRACT: Until recently, coronary artery disease (CAD) was the leading cause of death in the developed countries. Its remarkable decline can be attributed to our knowledge of the major risk factors identified by several studies resulting in better prevention and treatment. Of the major risk factors, the ratio of apolipoprotein (apo) B/apo A1 followed by smoking, diabetes, and hypertension are the most important. A number of risk scores for men and women are now available to estimate the likelihood of development of CAD. However, because of the risk of CAD differs in various populations, some of the algorithms are more appropriate for some countries but not suitable for others. These risk assessment algorithms differ in the parameters they use. All the risk scores have some limitations such as different study populations; the age of the study is also different, and number of points awarded for age categories also differs among the various algorithms. In an effort to further improve the risk prediction, a number of biomarkers have been studied. In addition to plasma lipids, a lot of interest has focused on apo measurements; particularly of apo B. Another valuable biomarker is lipoprotein (a) [Lp(a)]. Lp(a) is not only atherogenic as low-density lipoprotein (LDL) but also prothrombotic, and several studies indicate that Lp(a) is an independent risk factor for CAD. The lipid profile provides a framework for appropriate management. This includes therapeutic lifestyle changes and medications. Lifestyle interventions are the cornerstone of CAD prevention strategies and are the first step in risk factor management. Of particular importance are smoking cessation, achievement and maintenance of ideal body weight, regular exercise, reduction in the intake of saturated fat and sugars, and decreasing level of stress. Of medications, lipid-lowering, anti-hypertensive, and anti-coagulant can be effectively used. The current strategies for risk assessment and prevention have been very successful contributing to the more than 50% decrease in CAD mortality over the last 20 years. Thus, in Canada, cardiovascular disease is no longer the leading cause of death.

3 Article Low prevalence of type 2 diabetes mellitus among patients with high levels of high-density lipoprotein cholesterol. 2013

Juren, Andrew J / Sarwal, Gautamn / Al-Sarraf, Ahmad / Vrablik, Michal / Chan, Darren / Humphries, Karin H / Frohlich, Jiri J. ·Healthy Heart Program Prevention Clinic, James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St. Paul's Hospital, Vancouver, British Columbia, Canada. andrew.juren@stjohn.org ·J Clin Lipidol · Pubmed #23725918.

ABSTRACT: BACKGROUND: Diabetes mellitus and low levels of high-density lipoprotein cholesterol (HDL-C) are among several known risk factors for coronary artery disease. Recent research has shown potential mechanistic links between these two diseases. OBJECTIVES: The aim of our study was to characterize, by examining particular coronary artery disease risk factors, patients with extremely high and low levels of HDL-C who were referred to a prevention clinic. METHODS: We compared the phenotypes of 113 patients with HDL-C levels greater than the 90th percentile with 212 patients with levels less than the 10th percentile by using a retrospective chart review. RESULTS: The cohort with high HDL-C had a remarkable difference in the incidence of type 2 diabetes (1.8% vs 21.7%). The high HDL-C cohort also had a greater age (52.1 years vs 46.7 years), more light or moderate alcohol consumption (70.8% vs 49.4%), more healthy diet (30.1% vs 22.4%), more light or moderate exercise (90.8% vs 52.2%), and a lower body mass index (25.2 kg/m² vs 28.1 kg/m²). CONCLUSIONS: Compared with the low HDL-C group--and also the general population--the high HDL-C cohort had a remarkably low prevalence of diabetes mellitus.

4 Minor Cholesterol efflux capacity and atherosclerosis. 2011

Frohlich, Jiri / Al-Sarraf, Ahmad. · ·N Engl J Med · Pubmed #21488780.

ABSTRACT: -- No abstract --