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Coronary Artery Disease: HELP
Articles by J. Anthony Brandon
Based on 2 articles published since 2010
(Why 2 articles?)

Between 2010 and 2020, J. Brandon wrote the following 2 articles about Coronary Artery Disease.
+ Citations + Abstracts
1 Review Arguing the case for the autotaxin-lysophosphatidic acid-lipid phosphate phosphatase 3-signaling nexus in the development and complications of atherosclerosis. 2014

Smyth, Susan S / Mueller, Paul / Yang, Fanmuyi / Brandon, J Anthony / Morris, Andrew J. ·From the Veterans Affairs Medical Center, Cardiovascular Medicine Service, Lexington, KY (S.S.S., A.J.M.) · and Division of Cardiovascular Medicine, Gill Heart Institute, University of Kentucky, Lexington, KY (S.S.S., P.M., F.Y., J.A.B., A.J.M.). ·Arterioscler Thromb Vasc Biol · Pubmed #24482375.

ABSTRACT: The structurally simple glycero- and sphingo-phospholipids, lysophosphatidic acid (LPA) and sphingosine-1-phosphate, serve as important receptor-active mediators that influence blood and vascular cell function and are positioned to influence the events that contribute to the progression and complications of atherosclerosis. Growing evidence from preclinical animal models has implicated LPA, LPA receptors, and key enzymes involved in LPA metabolism in pathophysiologic events that may underlie atherosclerotic vascular disease. These observations are supported by genetic analysis in humans implicating a lipid phosphate phosphatase as a novel risk factor for coronary artery disease. In this review, we summarize current understanding of LPA production, metabolism, and signaling as may be relevant for atherosclerotic and other vascular disease.

2 Article Coronary Artery Disease Risk-Associated 2019

Mueller, Paul A / Yang, Liping / Ubele, Margo / Mao, Guogen / Brandon, Jason / Vandra, Julia / Nichols, Timothy C / Escalante-Alcalde, Diana / Morris, Andrew J / Smyth, Susan S. ·From the Division of Cardiovascular Medicine, The Gill Heart & Vascular Institute, University of Kentucky, Lexington (P.A.M., L.Y., M.U., G.M., J.B., J.V., A.J.M., S.S.S.). · Department of Pathology and Laboratory Medicine, University of North Carolina at Chapel Hill (T.C.N.). · División de Neurociencias, Instituto de Fisiología, Celular Universidad Nacional Autónoma de México, Ciudad de México, CDMX (D.E.-A.). · Department of Veterans Affairs Medical Center, Lexington, KY (A.J.M., S.S.S.). ·Arterioscler Thromb Vasc Biol · Pubmed #31533471.

ABSTRACT: OBJECTIVE: Genome-wide association studies identified novel loci in CONCLUSIONS: Our results identify a novel lipid signaling pathway that regulates inflammation in the context of atherosclerosis and is not related to traditional risk factors. Pharmacological targeting of bioactive LPP3 substrates, including LPA, may offer an orthogonal approach to lipid-lowering drugs for mitigation of coronary artery disease risk.