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Coronary Artery Disease: HELP
Articles by Mark Yan-Yee Chan
Based on 23 articles published since 2010
(Why 23 articles?)
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Between 2010 and 2020, Mark Chan wrote the following 23 articles about Coronary Artery Disease.
 
+ Citations + Abstracts
1 Review Biomarkers of Coronary Artery Disease Differ Between Asians and Caucasians in the General Population. 2015

Gijsberts, Crystel M / den Ruijter, Hester M / Asselbergs, Folkert W / Chan, Mark Y / de Kleijn, Dominique P V / Hoefer, Imo E. ·Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, the Netherlands; ICIN-Netherlands Heart Institute, Utrecht, the Netherlands. Electronic address: c.m.gijsberts@umcutrecht.nl. · Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, the Netherlands. · Department of Cardiology, University Medical Centre Utrecht, Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, the Netherlands; Institute of Cardiovascular Science, Population Health Sciences, University College London, London, United Kingdom. · Department of Cardiology, National University Singapore, Singapore; Cardiovascular Research Institute, National University Heart Centre Singapore, National University Health System, Singapore. · Laboratory of Experimental Cardiology, University Medical Centre Utrecht, Utrecht, the Netherlands; Cardiovascular Research Institute, National University Heart Centre Singapore, National University Health System, Singapore; Department of Surgery, National University Singapore, Singapore. ·Glob Heart · Pubmed #26014657.

ABSTRACT: Coronary artery disease (CAD) markers have not been thoroughly investigated among Asians. The incidence of CAD, however, is rising rapidly in Asia. In this review, we systematically discuss publications that compare CAD biomarkers between Asians and Caucasians in the general population. A PubMed search yielded 5,570 hits, containing 59 articles describing 47 unique cohorts that directly compare Asians with Caucasians. Ten biomarkers were taken into account for this review: total cholesterol; triglycerides; high-density lipoprotein cholesterol; low-density lipoprotein cholesterol; C-reactive protein; glucose; insulin; glycated hemoglobin; fibrinogen; and plasminogen activator inhibitor-1. Triglycerides were 1.13-fold higher in South Asians than in Caucasians, and insulin levels were 1.33-fold higher. In Japanese and Chinese subjects, lower C-reactive protein levels were reported: 0.52 and 0.36-fold, respectively. Ethnicity-specific prognostic measures of CAD biomarkers were rarely reported. CAD biomarker levels differ between Asians and Caucasians and among Asian ethnic groups in population-based cohorts. The ethnicity-specific prognostic value of CAD biomarkers is yet to be determined.

2 Review Translational platelet research in patients with coronary artery disease: what are the major knowledge gaps? 2012

Gurbel, Paul A / Roe, Matthew T / Jakubowski, Joseph A / Shah, Svathi / Erlinge, David / Goodman, Shaun G / Huber, Kurt / Chan, Mark Y / Cornel, Jan H / Tantry, Udaya S / Ohman, E Magnus. ·Sinai Center for Thrombosis Research, Cardiac Catheterization Laboratory, 2401 W. Belvedere Ave, Baltimore, MD 21215, USA. PGURBEL@LIFEBRIDGEHEALTH.ORG ·Thromb Haemost · Pubmed #22627684.

ABSTRACT: Translational platelet function investigations performed in the percutaneous coronary intervention (PCI)-treated population receiving clopidogrel have identified high platelet reactivity to ADP (HPR) as a major risk factor for both acute as well as long-term ischaemic event occurrence, including stent thrombosis. Recent studies have highlighted the relation of single nucleotide polymorphisms of genes involved in clopidogrel absorption and metabolism to reduced pharmacokinetic and pharmacodynamic responses to clopidogrel. CYP 2C19 loss-of-function (LoF) allele carriage has been associated with increased thrombotic risk in the PCI population. However, there is no information regarding the utility of platelet function testing to predict outcomes in patients with stable coronary artery disease and in medically managed patients with acute coronary syndromes. Additionally, few studies have included longitudinal assessment of platelet function to assess a potential time-dependent relation to ischaemic event occurrence and no phase-III antiplatelet-therapy trial has included a large enough platelet function sub-study to examine the relation between on-treatment platelet reactivity, bleeding, and ischaemic event occurrence. Therefore, futher studies are needed to delineate the role of platelet function testing across the spectrum of symptomatic coronary artery disease.

3 Clinical Trial Obstructive Sleep Apnea and Cardiovascular Events After Percutaneous Coronary Intervention. 2016

Lee, Chi-Hang / Sethi, Rishi / Li, Ruogu / Ho, Hee-Hwa / Hein, Thet / Jim, Man-Hong / Loo, Germaine / Koo, Chieh-Yang / Gao, Xiao-Fei / Chandra, Sharad / Yang, Xiao-Xiao / Furlan, Sofia F / Ge, Zhen / Mundhekar, Ajeya / Zhang, Wei-Wei / Uchôa, Carlos Henrique G / Kharwar, Rajiv Bharat / Chan, Po-Fun / Chen, Shao-Liang / Chan, Mark Y / Richards, Arthur Mark / Tan, Huay-Cheem / Ong, Thun-How / Roldan, Glenn / Tai, Bee-Choo / Drager, Luciano F / Zhang, Jun-Jie. ·From Department of Cardiology, National University Heart Centre, Singapore (C-H.L., G.L., C.-Y.K., P.-F.C., M.Y.C., A.M.R., H.-C.T.) · Department of Cardiology, King George's Medical University, Lucknow, India (R.S., S.C., A.M., R.B.K.) · Department of Cardiology, Shanghai Chest Hospital, China (R.L., X.-X.Y., W.-W.Z.) · Department of Cardiology, Tan Tock Seng Hospital, Singapore (H.-H.H.) · No (1) 1000-Bed Defence Services General Hospital, Mingaladon, Yangon, Myanmar (T.H.) · Cardiac Medical Unit, Grantham Hospital, Hong Kong (M.-H.J.) · Department of Cardiology, Nanjing First Hospital, Nanjing Medical University, China (X.-F.G., Z.G., S.-L.C., J.-J.Z.) · Hypertension Unit-Heart Institute (InCor), University of Sao Paulo Medical School, Brazil (S.F.F., C.H.G.U., L.F.D.) · Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore (T.-H.O.) · Sleep Educators, Antioch, CA (G.R.) · and Saw Swee Hock School of Public Health, National University of Singapore, Singapore (B.-C.T.). ·Circulation · Pubmed #27178625.

ABSTRACT: BACKGROUND: There is a paucity of data from large cohort studies examining the prognostic significance of obstructive sleep apnea (OSA) in patients with coronary artery disease. We hypothesized that OSA predicts subsequent major adverse cardiac and cerebrovascular events (MACCEs) in patients undergoing percutaneous coronary intervention. METHODS AND RESULTS: The Sleep and Stent Study was a prospective, multicenter registry of patients successfully treated with percutaneous coronary intervention in 5 countries. Between December 2011 and April 2014, 1748 eligible patients were prospectively enrolled. The 1311 patients who completed a sleep study within 7 days of percutaneous coronary intervention formed the cohort for this analysis. Drug-eluting stents were used in 80.1% and bioresorbable vascular scaffolds in 6.3% of the patients, and OSA, defined as an apnea-hypopnea index of ≥15 events per hour, was found in 45.3%. MACCEs, a composite of cardiovascular mortality, nonfatal myocardial infarction, nonfatal stroke, and unplanned revascularization, occurred in 141 patients during the median follow-up of 1.9 years (interquartile range, 0.8 years). The crude incidence of an MACCEs was higher in the OSA than the non-OSA group (3-year estimate, 18.9% versus 14.0%; p=0.001). Multivariate Cox regression analysis indicated that OSA was a predictor of MACCEs, with an adjusted hazard ratio of 1.57 (95% confidence interval, 1.10-2.24; P=0.013), independently of age, sex, ethnicity, body mass index, diabetes mellitus, and hypertension. CONCLUSIONS: OSA is independently associated with subsequent MACCEs in patients undergoing percutaneous coronary intervention. Evaluation of therapeutic approaches to mitigate OSA-associated risk is warranted. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT01306526.

4 Clinical Trial Ethnicity Modifies Associations between Cardiovascular Risk Factors and Disease Severity in Parallel Dutch and Singapore Coronary Cohorts. 2015

Gijsberts, Crystel M / Seneviratna, Aruni / de Carvalho, Leonardo P / den Ruijter, Hester M / Vidanapthirana, Puwalani / Sorokin, Vitaly / Stella, Pieter / Agostoni, Pierfrancesco / Asselbergs, Folkert W / Richards, A Mark / Low, Adrian F / Lee, Chi-Hang / Tan, Huay Cheem / Hoefer, Imo E / Pasterkamp, Gerard / de Kleijn, Dominique P V / Chan, Mark Y. ·Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands; The Netherlands Heart Institute (ICIN), Utrecht, The Netherlands. · Cardiac Department, National University Heart Centre, National University Hospital, Singapore, Singapore. · Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands. · Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. · Cardiology Department, University Medical Center Utrecht, Utrecht, The Netherlands. · Cardiology Department, University Medical Center Utrecht, Utrecht, The Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands; Institute of Cardiovascular Science, faculty of Population Health Sciences, University College London, London, United Kingdom. · Cardiac Department, National University Heart Centre, National University Hospital, Singapore, Singapore; Cardiovascular Research Institute (CVRI), National University Heart Centre (NUHCS), National University Health System, Singapore, Singapore. · Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands; The Netherlands Heart Institute (ICIN), Utrecht, The Netherlands; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore; Cardiovascular Research Institute (CVRI), National University Heart Centre (NUHCS), National University Health System, Singapore, Singapore. ·PLoS One · Pubmed #26147693.

ABSTRACT: BACKGROUND: In 2020 the largest number of patients with coronary artery disease (CAD) will be found in Asia. Published epidemiological and clinical reports are overwhelmingly derived from western (White) cohorts and data from Asia are scant. We compared CAD severity and all-cause mortality among 4 of the world's most populous ethnicities: Whites, Chinese, Indians and Malays. METHODS: The UNIted CORoNary cohort (UNICORN) simultaneously enrolled parallel populations of consecutive patients undergoing coronary angiography or intervention for suspected CAD in the Netherlands and Singapore. Using multivariable ordinal regression, we investigated the independent association of ethnicity with CAD severity and interactions between risk factors and ethnicity on CAD severity. Also, we compared all-cause mortality among the ethnic groups using multivariable Cox regression analysis. RESULTS: We included 1,759 White, 685 Chinese, 201 Indian and 224 Malay patients undergoing coronary angiography. We found distinct inter-ethnic differences in cardiovascular risk factors. Furthermore, the associations of gender and diabetes with severity of CAD were significantly stronger in Chinese than Whites. Chinese (OR 1.3 [1.1-1.7], p = 0.008) and Malay (OR 1.9 [1.4-2.6], p<0.001) ethnicity were independently associated with more severe CAD as compared to White ethnicity. Strikingly, when stratified for diabetes status, we found a significant association of all three Asian ethnic groups as compared to White ethnicity with more severe CAD among diabetics, but not in non-diabetics. Crude all-cause mortality did not differ, but when adjusted for covariates mortality was higher in Malays than the other ethnic groups. CONCLUSION: In this population of individuals undergoing coronary angiography, ethnicity is independently associated with the severity of CAD and modifies the strength of association between certain risk factors and CAD severity. Furthermore, mortality differs among ethnic groups. Our data provide insight in inter-ethnic differences in CAD risk factors, CAD severity and mortality.

5 Clinical Trial The influence of timing of polysomnography on diagnosis of obstructive sleep apnea in patients presenting with acute myocardial infarction and stable coronary artery disease. 2013

Low, Ting-Ting / Hong, Wei-Zhen / Tai, Bee-Choo / Hein, Thet / Khoo, See-Meng / Tan, Adeline Y / Chan, Mark Y / Richards, Mark / Lee, Chi-Hang. ·Department of Cardiology, National University Heart Centre, Singapore. ·Sleep Med · Pubmed #23890600.

ABSTRACT: BACKGROUND: We aimed to determine if timing of polysomnography (PSG) influences the diagnosis of obstructive sleep apnea (OSA) in acute myocardial infarction (AMI) or stable coronary artery disease (CAD). METHODS: A total of 160 patients admitted with AMI or stable CAD were consecutively recruited for either in-hospital (n=80) or postdischarge (n=80) PSG. RESULTS: The median time from admission to PSG for the in-hospital and postdischarge groups was 1 day and 17 days, respectively (P<.001). Overall, 59 patients (36.9%) were diagnosed with OSA (apnea-hypopnea index [AHI] > or = 15), and they were more likely to have diabetes mellitus (DM), hypertension, hyperlipidemia, chronic renal failure, and a greater body mass index (BMI) (P<.05 for all). The diagnosis of OSA was significantly higher (P=.037) in patients who had a PSG performed as an inpatient than those who had a PSG as an outpatient. There was a significant interaction between clinical presentation and the effect of PSG timing on the diagnosis of OSA (P=.003). For the patients presenting with AMI but not those with stable CAD, in-hospital PSG was an independent predictor of OSA (adjusted odds ratio, 3.84 [95% confidence interval, 1.42-10.41]; P=.008). CONCLUSION: The timing of PSG influenced the diagnosis of OSA in patients who presented with AMI but not in those who presented with stable CAD.

6 Article Plasma Ceramides as Prognostic Biomarkers and Their Arterial and Myocardial Tissue Correlates in Acute Myocardial Infarction. 2018

de Carvalho, Leonardo P / Tan, Sock Hwee / Ow, Ghim-Siong / Tang, Zhiqun / Ching, Jianhong / Kovalik, Jean-Paul / Poh, Sock Cheng / Chin, Chee-Tang / Richards, A Mark / Martinez, Eliana C / Troughton, Richard W / Fong, Alan Yean-Yip / Yan, Bryan P / Seneviratna, Aruni / Sorokin, Vitaly / Summers, Scott A / Kuznetsov, Vladimir A / Chan, Mark Y. ·Federal University of Sao Paulo State, Sao Paulo, Brazil. · National University Heart Center, Singapore, Singapore. · Cardiovascular Research Institute, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. · Albert Einstein Hospital, São Paulo, Brazil. · Bioinformatics Institute, ASTAR, Singapore. · Institute of Molecular and Cell Biology, ASTAR, Singapore. · Program in Cardiovascular and Metabolic Disorders, Duke-National University of Singapore Graduate Medical School, Singapore. · National Heart Centre Singapore, Singapore. · Christchurch Heart Institute, University of Otago Christchurch, Christchurch Hospital, Christchurch, New Zealand. · Miller School of Medicine, University of Miami, Miami, Florida. · Clinical Research Centre, Sarawak General Hospital, Kuching, Malaysia. · Department of Cardiology, Sarawak General Hospital, Kuching, Malaysia. · Department of Medicine & Therapeutics, The Chinese University of Hong Kong, Hong Kong, China. · University of Utah, Salt Lake City, Utah. · Nanyang Institute of Technology in Health & Medicine, Nanyang Technological University, Singapore. ·JACC Basic Transl Sci · Pubmed #30062203.

ABSTRACT: We identified a plasma signature of 11 C14 to C26 ceramides and 1 C16 dihydroceramide predictive of major adverse cardiovascular events in patients with acute myocardial infarction (AMI). Among patients undergoing coronary artery bypass surgery, those with recent AMI, compared with those without recent AMI, showed a significant increase in 5 of the signature's 12 ceramides in plasma but not simultaneously-biopsied aortic tissue. In contrast, a rat AMI model, compared with sham control, showed a significant increase in myocardial concentrations of all 12 ceramides and up-regulation of 3 ceramide-producing enzymes, suggesting ischemic myocardium as a possible source of this ceramide signature.

7 Article Cost-effectiveness analysis of biodegradable polymer versus durable polymer drug-eluting stents incorporating real-world evidence. 2018

Teng, Monica / Zhao, Ying Jiao / Khoo, Ai Leng / Ananthakrishna, Rajiv / Yeo, Tiong Cheng / Lim, Boon Peng / Chan, Mark Y / Loh, Joshua P. ·Pharmacy and Therapeutics Office, Group Health Informatics, National Healthcare Group, Singapore, Singapore. · Department of Cardiology, National University Heart Centre, Singapore, Singapore. · Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ·Cardiovasc Ther · Pubmed #29873191.

ABSTRACT: AIM: Compared with second-generation durable polymer drug-eluting stents (DP-DES), the cost-effectiveness of biodegradable polymer drug-eluting stents (BP-DES) remains unclear in the real-world setting. We assessed the cost-effectiveness of BP-DES in patients with coronary artery disease undergoing percutaneous coronary intervention (PCI). METHODS: We developed a decision-analytic model to compare the cost-effectiveness of BP-DES to DP-DES over 1 year and 5 years from healthcare payer perspective. Relative treatment effects during the first year post-PCI were obtained from a real-world population analysis while clinical event risks in the subsequent 4 years were derived from a meta-analysis of published studies. RESULTS: At 1 year, based on the clinical data analysis of 497 propensity-score matched pairs of patients, BP-DES were associated with an incremental cost-effectiveness ratio (ICER) of USD20 503 per quality-adjusted life-year (QALY) gained. At 5 years, BP-DES yielded an ICER of USD4062 per QALY gained. At the willingness-to-pay threshold of USD50 400 (one gross domestic product per capita in Singapore in 2015), BP-DES were cost-effective. Sensitivity analysis showed that the cost of stents had a significant impact on the cost-effectiveness of BP-DES. Threshold analysis demonstrated that if the cost difference between BP-DES and DP-DES exceeded USD493, BP-DES would not be cost-effective in patients with 1 year of follow-up. CONCLUSIONS: Biodegradable polymer drug-eluting stents were cost-effective compared with DP-DES in patients with coronary artery disease at 1 year and 5 years after PCI. It is worth noting that the cost of stents had a significant impact on the findings.

8 Article Treatment of Very Small De Novo Coronary Artery Disease With 2.0 mm Drug-Coated Balloons Showed 1-Year Clinical Outcome Comparable With 2.0 mm Drug-Eluting Stents. 2018

Sim, Hui Wen / Ananthakrishna, Rajiv / Chan, Siew Pang / Low, Adrian F / Lee, Chi-Hang / Chan, Mark Y / Tay, Edgar L / Loh, Poay Huan / Chan, Koo Hui / Tan, Huay Cheem / Loh, Joshua P. ·Department of Cardiology, National University Heart Centre, 1E Kent Ridge Road, NUHS Tower Block, Level 9, Singapore 119228. joshua_py_loh@nuhs.edu.sg. ·J Invasive Cardiol · Pubmed #29656281.

ABSTRACT: OBJECTIVE: To evaluate the 1-year clinical outcomes of patients treated with 2.0 mm drug-coated balloon (DCB) vs 2.0 mm drug-eluting stent (DES) implantation in small-caliber vessel de novo coronary artery disease (CAD). METHODS: All patients treated with 2.0 mm DCB or 2.0 mm DES for very small vessel de novo CAD from July 2014 to June 2016 were included in this study. The primary endpoint was the occurrence of target-lesion failure (TLF) and time to TLF, defined as a combination of cardiac mortality, target-vessel myocardial infarction, and target-lesion revascularization (TLR). RESULTS: A total of 87 patients (96 lesions) were implanted with 2.0 mm DCBs and 200 patients (223 lesions) were implanted with 2.0 mm DESs during the study period. Mean reference vessel diameter was similar between the DCB and DES groups (1.88 ± 0.38 mm vs 1.95 ± 0.21 mm, respectively; P=.11). The 1-year TLF rates were 7.0% in the DCB group and 8.2% in the DES group (P=.73). TLF was driven by TLR in both groups. Bailout stenting was performed in 7 patients (8 lesions) who received a DCB. Stent thrombosis was seen in 4 patients (2.0%) who underwent DES implantation. There was no vessel thrombosis noted in the DCB group. Cardiogenic shock was identified as a direct and significant predictor for both the occurrence of TLF and time to TLF. CONCLUSIONS: In this first report, treatment of very small vessel CAD with 2.0 mm DCB vs 2.0 mm DES was associated with similar 1-year TLF rates.

9 Article Incidence and predictors of target lesion failure in a multiethnic Asian population receiving the SYNERGY coronary stent: A prospective all-comers registry. 2018

Ananthakrishna, Rajiv / Kristanto, William / Liu, Li / Chan, Siew-Pang / Loh, Poay Huan / Tay, Edgar L / Chan, Koo Hui / Chan, Mark Y / Lee, Chi-Hang / Low, Adrian F / Tan, Huay Cheem / Loh, Joshua P. ·Department of Cardiology, National University Heart Centre, Singapore. ·Catheter Cardiovasc Interv · Pubmed #29513378.

ABSTRACT: OBJECTIVES: To evaluate the target lesion failure (TLF) rate of the SYNERGY stent in all-comers, multiethnic Asian population. BACKGROUND: Currently, most drug eluting stents deliver anti-proliferative drugs from a durable polymer which is associated with a risk of late stent thrombosis. The novel everolimus-eluting, platinum chromium SYNERGY stent is coated with a bioabsorbable abluminal polymer that resolves within 4 months. METHODS: This was a prospective, single center registry of consecutive patients treated with the SYNERGY stent between December 2012 and April 2015. The primary outcome was the incidence of TLF, defined as the combination of cardiac death, target vessel myocardial infarction, or clinically driven target lesion revascularization (TLR) at 1 year. RESULTS: A total of 807 patients received the SYNERGY stent during the study period. One-year clinical outcome data was available for 765 patients (94.8%) and were considered for statistical analysis. The mean age was 60.7 ± 10.8 years, and 83.4% were males. Patients with acute myocardial infarction consisted of 50.3% (ST-segment elevation myocardial infarction: 23.0%, Non-ST-segment elevation myocardial infarction: 27.3%) of the study population. The treated lesions were complex (ACC/AHA type B2/C: 72.7%). The primary end point of TLF at 1 year was 5.8%. Rates of cardiac mortality, target vessel myocardial infarction, and TLR were 4.2, 1.0, and 1.3%, respectively, at 1 year. Predictors of the incidence and time to early TLF were female gender, Malay ethnicity, diabetes mellitus, acute myocardial infarction at presentation, a prior history of coronary artery bypass surgery and the presence of lesion calcification. The incidence of definite stent thrombosis was 0.4% at 1 year. CONCLUSIONS: In this registry, the use of the SYNERGY stent was associated with low rates of TLF at 1 year.

10 Article A propensity score-matched comparison of biodegradable polymer vs second-generation durable polymer drug-eluting stents in a real-world population. 2018

Zhao, Ying Jiao / Teng, Monica / Khoo, Ai Leng / Ananthakrishna, Rajiv / Yeo, Tiong Cheng / Lim, Boon Peng / Loh, Joshua P / Chan, Mark Y. ·Pharmacy and Therapeutics Office, Group Corporate Development, National Healthcare Group, Singapore City, Singapore. · Department of Cardiology, National University Heart Centre, Singapore City, Singapore. · Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore City, Singapore. ·Cardiovasc Ther · Pubmed #29316284.

ABSTRACT: AIMS: The safety and efficacy of BP-DES compared to second-generation DP-DES remain unclear in the real-world setting. We compared the clinical outcomes of biodegradable polymer drug-eluting stents (BP-DES) with second-generation durable polymer drug-eluting stents (DP-DES) in an all-comer percutaneous coronary intervention (PCI) registry. METHODS/RESULTS: The study included a cohort of 1065 patients treated with either BP-DES or DP-DES from January 2009 through October 2015. Propensity score matching was performed to account for potential confounders and produced 497 matched pairs of patients. The primary endpoint was target lesion failure (TLF) at one-year follow-up. The rates of TLF were comparable between BP-DES and DP-DES (8.7% vs 9.1%, P = .823) at 1 year. The rates of stent thrombosis at 30 days (0.4% vs 0.4%, P = 1.00) and 1 year (0.8% vs 0.8%, P = 1.00) did not differ between BP-DES and DP-DES. There were no significant differences in other clinical outcomes including target vessel failure (8.9% vs 9.5%, P = .741), in-stent restenosis (1.8% vs 1.0%, P = .282), and cardiac death (6.4% vs 7.4%, P = .533) at 1 year. Multivariate cox regression analysis showed that the risk of TLF at one-year did not differ significantly between BP-DES and DP-DES (hazard ratio 0.94, P = .763). CONCLUSIONS: Efficacy and safety of BP-DES were not better than DP-DES at one-year follow-up.

11 Article Hybrid PET/CT and PET/MRI imaging of vulnerable coronary plaque and myocardial scar tissue in acute myocardial infarction. 2018

Marchesseau, Stephanie / Seneviratna, Aruni / Sjöholm, A Therese / Qin, Daphne Liang / Ho, Jamie X M / Hausenloy, Derek J / Townsend, David W / Richards, A Mark / Totman, John J / Chan, Mark Y Y. ·Clinical Imaging Research Centre, A*STAR-NUS, Singapore, Singapore. marchesseau.stephanie@gmail.com. · Department of Cardiology, National University Heart Centre, Singapore, Singapore. · Clinical Imaging Research Centre, A*STAR-NUS, Singapore, Singapore. · Department of Radiology, Uppsala University, Uppsala, Sweden. · The Hatter Cardiovascular Institute, University College London, London, UK. · The National Institute of Health Research University College London Hospitals Biomedical Research Centre, London, UK. · National Heart Research Institute Singapore, National Heart Centre Singapore, Singapore, Singapore. · Cardiovascular and Metabolic Disorders Program, Duke-National University of Singapore Medical School, Singapore, Singapore. · Cardiovascular Research Institute, NUHS, Singapore, Singapore. ·J Nucl Cardiol · Pubmed #28500539.

ABSTRACT: BACKGROUND: Following an acute coronary syndrome, combined CT and PET with METHODS AND RESULTS: Ten patients with STEMI were scanned after CONCLUSIONS: We confirmed the potential of

12 Article Genome-wide association study identifies a missense variant at APOA5 for coronary artery disease in Multi-Ethnic Cohorts from Southeast Asia. 2017

Han, Yi / Dorajoo, Rajkumar / Chang, Xuling / Wang, Ling / Khor, Chiea-Chuen / Sim, Xueling / Cheng, Ching-Yu / Shi, Yuan / Tham, Yih Chung / Zhao, Wanting / Chee, Miao Ling / Sabanayagam, Charumathi / Chee, Miao Li / Tan, Nicholas / Wong, Tien Yin / Tai, E-Shyong / Liu, Jianjun / Goh, Daniel Y T / Yuan, Jian-Min / Koh, Woon-Puay / van Dam, Rob M / Low, Adrian F / Chan, Mark Yan-Yee / Friedlander, Yechiel / Heng, Chew-Kiat. ·Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore; and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore. · Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore. · Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore. · Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. · Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore. · Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. · Centre for Quantitative Medicine, Duke-NUS Graduate Medical School, Singapore, Singapore. · Department of Ophthalmology, National University Hospital, Singapore, Singapore. · Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore. · Department of Epidemiology, Graduate School of Public Health; and University of Pittsburgh Cancer Institute, University of Pittsburgh, Pittsburgh, Pennsylvania, USA. · Duke-NUS Graduate Medical School Singapore, Singapore, Singapore. · Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. · National University Heart Centre, National University Health System, Singapore, Singapore. · School of Public Health and Community Medicine, Hebrew University of Jerusalem, Jerusalem, Israel. yechielf@ekmd.huji.ac.il. · Department of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore; and Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore, Singapore. paehck@nus.edu.sg. ·Sci Rep · Pubmed #29263402.

ABSTRACT: Recent genome-wide association studies (GWAS) have identified multiple loci associated with coronary artery disease (CAD) among predominantly Europeans. However, their relevance to multi-ethnic populations from Southeast Asia is largely unknown. We performed a meta-analysis of four GWAS comprising three Chinese studies and one Malay study (Total N = 2,169 CAD cases and 7,376 controls). Top hits (P < 5 × 10

13 Article Inter-Ethnic Differences in Quantified Coronary Artery Disease Severity and All-Cause Mortality among Dutch and Singaporean Percutaneous Coronary Intervention Patients. 2015

Gijsberts, Crystel M / Seneviratna, Aruni / Hoefer, Imo E / Agostoni, Pierfrancesco / Rittersma, Saskia Z H / Pasterkamp, Gerard / Hartman, Mikael / Pinto de Carvalho, Leonardo / Richards, A Mark / Asselbergs, Folkert W / de Kleijn, Dominique P V / Chan, Mark Y. ·Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands; The Netherlands Heart Institute (ICIN), Utrecht, the Netherlands. · Cardiac Department, National University Hospital, Singapore. · Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands. · Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands. · Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Saw Swee Hock School of Public Health, National University of Singapore, Singapore. · Cardiac Department, National University Hospital, Singapore; Department of Cardiology, Albert Einstein Hospital, Sao Paulo, Brazil. · Cardiac Department, National University Hospital, Singapore; Cardiovascular Research Institute (CVRI), National University Heart Centre (NUHCS), National University Health System, Singapore. · Department of Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands; Durrer Center for Cardiogenetic Research, ICIN-Netherlands Heart Institute, Utrecht, The Netherlands; Institute of Cardiovascular Science, faculty of Population Health Sciences, University College London, London, United Kingdom. · Laboratory of Experimental Cardiology, University Medical Center Utrecht, Utrecht, the Netherlands; The Netherlands Heart Institute (ICIN), Utrecht, the Netherlands; Department of Surgery, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; Cardiovascular Research Institute (CVRI), National University Heart Centre (NUHCS), National University Health System, Singapore. ·PLoS One · Pubmed #26147437.

ABSTRACT: BACKGROUND: Coronary artery disease (CAD) is a global problem with increasing incidence in Asia. Prior studies reported inter-ethnic differences in the prevalence of CAD rather than the severity of CAD. The angiographic "synergy between percutaneous coronary intervention (PCI) with taxus and cardiac surgery" (SYNTAX) score quantifies CAD severity and predicts outcomes. We studied CAD severity and all-cause mortality in four globally populous ethnic groups: Caucasians, Chinese, Indians and Malays. METHODS: We quantified SYNTAX scores of 1,000 multi-ethnic patients undergoing PCI in two tertiary hospitals in the Netherlands (Caucasians) and Singapore (Chinese, Indians and Malays). Within each ethnicity we studied 150 patients with stable CAD and 100 with ST-elevated myocardial infarction (STEMI). We made inter-ethnic comparisons of SYNTAX scores and all-cause mortality. RESULTS: Despite having a younger age (mean age Indians: 56.8 and Malays: 57.7 vs. Caucasians: 63.7 years), multivariable adjusted SYNTAX scores were significantly higher in Indians and Malays than Caucasians with stable CAD: 13.4 [11.9-14.9] and 13.4 [12.0-14.8] vs. 9.4 [8.1-10.8], p<0.001. Among STEMI patients, SYNTAX scores were highest in Chinese and Malays: 17.7 [15.9-19.5] and 18.8 [17.1-20.6] vs. 15.5 [13.5-17.4] and 12.7 [10.9-14.6] in Indians and Caucasians, p<0.001. Over a median follow-up of 709 days, 67 deaths (stable CAD: 37, STEMI: 30) occurred. Among STEMI patients, the SYNTAX score independently predicted all-cause mortality: HR 2.5 [1.7-3.8], p<0.001 for every 10-point increase. All-cause mortality was higher in Indian and Malay STEMI patients than Caucasians, independent of SYNTAX score (adjusted HR 7.2 [1.5-34.7], p=0.01 and 5.8 [1.2-27.2], p=0.02). CONCLUSION: Among stable CAD and STEMI patients requiring PCI, CAD is more severe in Indians and Malays than in Caucasians, despite having a younger age. Moreover, Indian and Malay STEMI patients had a greater adjusted risk of all-cause mortality than Caucasians, independent of SYNTAX score.

14 Article High-grade culprit lesions are a common cause of ST-segment elevation myocardial infarction. 2015

Liang, Michael / Kajiya, Takashi / Chan, Mark Y / Tay, Edgar / Lee, Chi-Hang / Richards, Arthur Mark / Low, Adrian F / Tan, Huay Cheem. ·National University Heart Centre Singapore, Singapore. ·Singapore Med J · Pubmed #26106241.

ABSTRACT: INTRODUCTION: Conventional knowledge holds that the majority of ruptured atherosclerotic plaques causing ST-segment elevation myocardial infarction (STEMI) are found in moderate stenoses that produce < 50% loss of arterial diameter. This study aimed to analyse the culprit lesions in patients who presented with STEMI and underwent primary percutaneous coronary intervention (PPCI) at our institution. METHODS: Patients who underwent PPCI between June 2008 and August 2010 at our institution were included in the analysis. Quantitative coronary angiography was performed for the culprit lesions immediately after antegrade flow was restored by thrombectomy, low-profile balloon predilatation or guidewire crossing. RESULTS: A total of 1,021 patients were included in the study. The mean age was 57 ± 12 years and 85.2% were male. Lesion measurement was done after coronary flow was restored by thrombectomy (73.1%), balloon dilatation (24.1%) and following guidewire passage across the lesion (2.8%). Mean minimal luminal diameter was 1.1 ± 0.5 mm, mean reference vessel diameter was 2.8 ± 0.6 mm, mean diameter stenosis was 61 ± 16% and mean lesion length was 16 ± 6 mm. Most (80.2%) of the culprit lesions had diameter stenoses > 50% (p < 0.01). Although balloon angioplasty was performed in 24.1% of the patients, the majority (64.2%) still had diameter stenoses > 50%. High-grade stenoses (> 50%) were more frequently observed in male patients (p = 0.04). CONCLUSION: Contrary to the existing paradigm, we found that most of the patients with STEMI in our institution had culprit lesions with diameter stenosis > 50%.

15 Article Highly sensitive and quantitative human thrombospondin-1 detection by an M55 aptasensor and clinical validation in patients with atherosclerotic disease. 2014

Ji, Kaili / de Carvalho, Leonardo Pinto / Bi, Xuezhi / Seneviratnankn, Aruni / Bhakoo, Kishore / Chan, Mark / Yau Li, Sam Fong. ·NUS Graduate School for Integrative Sciences and Engineering, National University of Singapore, Singapore 119077, Singapore. · Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore. · Bioprocessing Technology Institute, Agency for Science, Technology and Research, 20 Biopolis Way, #06-01, Singapore 138668, Singapore. · Translational Molecular Imaging Group, Singapore Bioimaging Consortium, Agency for Science, Technology and Research, Singapore 138667, Singapore. · National University Heart Centre, Singapore 119074, Singapore. · Department of Chemistry and NUS Environmental Research Institute, National University of Singapore, Singapore 117543, Singapore; Shenzhen Engineering Laboratory for Eco-efficient Polysilicate Materials, Peking University Shenzhen Graduate School, Shenzhen, P.R.C. 518055. Electronic address: chmlifys@nus.edu.sg. ·Biosens Bioelectron · Pubmed #24434496.

ABSTRACT: Aptamer-based biosensors (aptasensor) are powerful tools for rapid and sensitive biomarker detection. In this study, we report a DNA aptamer probe evolved from cell-SELEX that can recognize thrombospondin-1 protein in human plasma samples. The KD value of the aptamer M55 binding to thrombospondin-1 was determined as 0.5 ± 0.2 μM with an R(2) of 0.9144. A horseradish peroxidase-linked short oligo was complementarily bound onto the 3' end of the aptamer sequence to facilitate the 'smart' design of an M55-aptasensor for quantifying thrombospondin-1 protein in plasma samples. The limit of detection was 6.96 fM. Thrombospondin-1 is a glycoprotein with multiple biological functions, including inflammation, platelet aggregation and endothelial cell apoptosis, and is involved in the pathology of atherosclerosis. In total, 118 plasma subjects were analyzed by using the aptasensor measurement with 1 μL sample volume and 5 min incubation time. The thrombospondin-1 concentrations in ST-Elevation Myocardial Infarction patients with severe atherosclerotic plaque burden were statistically significantly higher than in the healthy volunteers without atherosclerosis conditions, suggesting that thromboposnidn-1 is a potential plasma biomarker for atherosclerosis progression.

16 Article Excessive daytime sleepiness is associated with longer culprit lesion and adverse outcomes in patients with coronary artery disease. 2013

Lee, Chi-Hang / Ng, Wai-Yee / Hau, William / Ho, Hee-Hwa / Tai, Bee-Choo / Chan, Mark Y / Richards, A Mark / Tan, Huay-Cheem. ·Department of Cardiology, National University Heart Centre, Singapore ; Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore. ·J Clin Sleep Med · Pubmed #24340288.

ABSTRACT: STUDY OBJECTIVES: We assessed whether excessive daytime sleepiness was associated with coronary plaque phenotype and subsequent adverse cardiovascular events. METHODS: Prospective cohort study. Intravascular ultrasound (IVUS) examination of the culprit coronary stenosis was performed. The Epworth Sleepiness Scale (ESS) questionnaire was administered, and the patients were divided into 2 groups-(1) sleepier and (2) less sleepy-based on the ESS score. Adverse cardiovascular outcomes were defined as cardiac death, myocardial infarction, stroke, unplanned revascularization, or heart failure admission. RESULTS: One hundred seventeen patients undergoing urgent or non-urgent coronary angiography were recruited. Compared with the less sleepy group (ESS ≤ 10, n = 87), the sleepier group (ESS > 10, n = 30) had higher serum levels of total cholesterol and of low-density-lipoprotein cholesterols (p < 0.05 for both). The IVUS examinations indicated coronary stenoses were longer in the sleepier group than in the less sleepy group (p = 0.011). The cumulative incidence of adverse cardiovascular events at 16-month follow-up was higher in the sleepier than the less sleepy group (12.5% versus 6.9%, p = 0.03). Cox regression analysis adjusting for age and smoking showed increased hazard of adverse cardiovascular events in sleepier group as compared to less sleepy group (HR = 3.44, 95% CI 1.01-11.72). CONCLUSION: In patients presenting with coronary artery disease, excessive daytime sleepiness based on ESS > 10 was associated with longer culprit lesions and future adverse cardiovascular events.

17 Article Relationship between apnoea-hypopnoea index and angiographic
coronary disease phenotypes in patients presenting with acute
myocardial infarction. 2013

Hein, Thet / Loo, Germaine / Ng, Wai-Yee / Tai, Bee-Choo / Kajiya, Takashi / Tan, Adeline / Khoo, See-Meng / Chan, Mark / Low, Adrian F / Chia, Boon-Lock / Richards, Mark / Lee, Chi-Hang. ·National University Heart Centre Singapore, National University Health System, Singapore. ·Acute Card Care · Pubmed #23738622.

ABSTRACT: BACKGROUND: Relationship between obstructive sleep apnoea and atherosclerosis has not been confirmed using coronary angiography. We sought to investigate the relationships between the apnoea-hypopnoea index (AHI) and angiographic coronary disease phenotypes.
 METHODS: SYNTAX score, lesion complexity, and thrombus burden grade were determined in 125 patients presenting with acute myocardial infarction and had undergone a screening sleep study. Severe OSA was defined as AHI ≥ 30.
 RESULTS: Most of the recruited patients were male (97.6%). Severe obstructive sleep apnoea was diagnosed in 37% of the patients. The severe obstructive sleep apnoea group (n = 46) was older (P = 0.039) and more obese (P = 0.003) than the non-severe group (n = 79). There was no evidence of difference between the severe and non-severe obstructive sleep apnoea groups with regard to SYNTAX score (P = 0.871), number of complex lesions (P = 0.241), and thrombus burden grade (P = 0.433). Multivariate analysis adjusting for difference in age and body mass index did not change the findings. CONCLUSION: Using the three angiographic scoring systems, we found no association between AHI and angiographic coronary disease phenotypes, suggesting a limited effect of obstructive sleep apnoea on the amount and distribution of coronary plaques in patients presenting with acute myocardial infarction.

18 Article Everolimus-eluting bioresorbable vascular scaffold (BVS) implantation in patients with ST-segment elevation myocardial infarction (STEMI). 2013

Kajiya, Takashi / Liang, Michael / Sharma, Ranjit Kumar / Lee, Chi-Hang / Chan, Mark Y / Tay, Edgar / Chan, Koo-Hui / Tan, Huay-Cheem / Low, Adrian F. ·Cardiac Department, National University Heart Centre Singapore, Singapore. ·EuroIntervention · Pubmed #23687101.

ABSTRACT: AIMS: Recent studies have demonstrated favourable clinical outcomes for the everolimus-eluting bioresorbable vascular scaffold (BVS) ABSORB™ in patients with stable coronary artery disease. There are currently no data on its use in patients with ST-segment elevation myocardial infarction (STEMI). We assessed the safety and impact of BVS in the setting of primary percutaneous coronary intervention (PCI) in patients presenting with STEMI to our institution. METHODS AND RESULTS: A total of 11 patients who underwent primary PCI with intent for BVS implantation between October 2012 and April 2013 at our institution were included. Median follow-up period was 53.0 ± 45.9 days. One patient presented to the hospital with cardiogenic shock and subsequently died. The other 10 patients did not have any major adverse cardiac events (MACE). There were no acute or subacute stent thromboses at short-term follow-up. CONCLUSIONS: These are the first real-world data using BVS in patients with STEMI. The ABSORB™ BVS may be safely used in patients with STEMI undergoing primary PCI with favourable short-term outcome.

19 Article Adiponectin profile in Asian patients undergoing coronary revascularization and its association with plaque vulnerability: IDEAS-ADIPO study. 2012

Lee, Chi-Hang / Hau, William K T / Tai, Bee-Choo / Chan, Mark Y / Saw, Betty / Phua, Qian-Hui / Low, Adrian F / Yeo, Tiong-Cheng / Richards, A Mark / Tan, Huay-Cheem. ·Department of Medicine, National University of Singapore, Singapore. mdclchr@nus.edu.sg) ·Obesity (Silver Spring) · Pubmed #22510959.

ABSTRACT: Despite potent insulin-sensitizing, anti-inflammatory, and antiatherogenic effects in animal studies, the relationship between serum adiponectin level and coronary artery disease in patients remains unclear. We determined the adiponectin profile in a cohort of multiethnic Asian patients with coronary artery disease, and the association between serum adiponectin level and culprit lesion necrotic core (NC) content. Ninety-four Asian patients (BMI, 25.3 ± 3.7 kg/m(2)) undergoing percutaneous coronary intervention were recruited. The serum adiponectin level was measured (n = 94), and the baseline virtual histology intravascular ultrasound examination was analyzed (n = 88). The median level of adiponectin was 3.7 µg/ml (interquartile range, 2.8-4.5 µg/ml). The serum adiponectin level was below 10 µg/ml in 90 patients (95.7%) and below 6 µg/ml in 80 patients (85.1%). There was a significant association between ethnicity and serum adiponectin level (P = 0.048). The median adiponectin level was highest among the Chinese, followed by the Malay and the Indians. Serum adiponectin levels were positively associated with culprit lesion NC content. A 1-µg/ml increase in log adiponectin was associated with a 3.04% (95% confidence interval: 0.33-5.44) increase in culprit lesion NC content. This association remains significant after adjusting for age, sex, ethnicity, low-density lipoprotein cholesterol, high-density lipoprotein cholesterol, and procedural indication. We found a low serum level of adiponectin in Asian patients and a significant ethnic effect on serum adiponectin level. Increased serum adiponectin levels were independently associated with increased culprit lesion NC burden, suggesting a role for adiponectin in modulating coronary plaque vulnerability.

20 Article Correlation between high density lipoprotein-cholesterol and remodeling index in patients with coronary artery disease: IDEAS (IVUS diagnostic evaluation of atherosclerosis in Singapore)-HDL study. 2012

Lee, Chi-Hang / Tai, Bee-Choo / Lim, Gek-Hsiang / Chan, Mark Y / Low, Adrian F / Tan, Kathryn C / Chia, Boon-Lock / Tan, Huay-Cheem. ·Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Kent Ridge, Singapore. mdclchr@nus.edu.sg ·Int J Cardiovasc Imaging · Pubmed #21197580.

ABSTRACT: Serum level of high density lipoprotein (HDL)-cholesterol is associated with risk of coronary artery disease. We correlated the serum level of cholesterol with coronary artery remodeling index of patients with coronary artery disease. A total of 120 patients with de novo lesions located in native coronary artery were studied. Remodeling index was based on intravascular ultrasound (IVUS) interrogation of the lesions using the static approach, and was defined as external elastic membrane (EEM) area at lesion/average EEM area at proximal and distal reference segments. The average remodeling index was 0.9 (SD: 0.2). The remodeling index was not associated with any of the demographic and coronary risk factors. Stable angina was associated with a low remodeling index. Remodeling index correlated with white blood cell count and HDL-cholesterol, but not with total cholesterol, LDL-cholesterol and triglyceride. In the multiple linear regression analysis, HDL-cholesterol and procedure indication were the only 2 significant predictors of remodeling index. An increase of 1 mg/dL of HDL-cholesterol resulted in a decrease of 0.003 (95% CI: 0.0001, 0.007; P = 0.046) in remodeling index, after adjusting for procedural indications. When stratified according to diabetic status, the negative correlation persisted in non-diabetic (P = 0.023), but not in diabetic, patients (P = 0.707). We found a negative correlation between HDL-cholesterol level and remodeling index. Diabetic status may have an influence on the observed relationship.

21 Article An anti-von Willebrand factor aptamer reduces platelet adhesion among patients receiving aspirin and clopidogrel in an ex vivo shear-induced arterial thrombosis. 2011

Arzamendi, Dabit / Dandachli, Firas / Théorêt, Jean-François / Ducrocq, Gregory / Chan, Mark / Mourad, Walid / Gilbert, James C / Schaub, Robert G / Tanguay, Jean-François / Merhi, Yahye. ·Department of Medicine, Montreal Heart Institute, Université de Montréal, Montreal, Canada. ·Clin Appl Thromb Hemost · Pubmed #21078615.

ABSTRACT: The von Willebrand factor (vWF) aptamer, ARC1779 that blocks the binding of vWF A1-domain to platelet glycoprotein 1b (GPIb) at high shear, may deliver a site-specific antithrombotic effect. We investigated the efficiency of ARC1779 on platelet function in patients with coronary artery disease (CAD) on double antiplatelet therapy. Blood from patients taking aspirin and clopidogrel and from normal volunteers was treated ex vivo with ARC1779 or abciximab, either prior to perfusion (pretherapy) or 10 minutes following the initiation of perfusion (posttherapy) on damaged arteries. Under pre- but not posttherapy, platelet adhesion was significantly reduced by ARC1779 at 83 and 250 nmol/L and by abciximab (100 nmol/L) versus placebo (4.8, 3.8, and 2.9 vs 7.3 platelets × 10(6)/cm(2), P < .05). In contrast to abciximab, ARC1779 did not significantly affect platelet aggregation, P-selectin expression, and platelet-leukocyte binding. These proof-of-concept data may constitute the framework for randomized clinical investigations of this novel antiplatelet therapy among patients with CAD.

22 Minor Paradoxical effects of adiponectin level on plaque vulnerability and clinical outcomes after coronary revascularization. 2013

Kajiya, Takashi / Er, Benjamin H / Chan, Mark Y / Low, Adrian F / Tan, Huay-Cheem / Tai, Bee-Choo / Lee, Chi-Hang. ·Department of Cardiology, National University Heart Center, Singapore. ·Int J Cardiol · Pubmed #23886528.

ABSTRACT: -- No abstract --

23 Minor Initial experience in the clinical use of everolimus-eluting bioresorbable vascular scaffold (BVS) in a single institution. 2013

Liang, Michael / Kajiya, Takashi / Lee, Chi-Hang / Chan, Mark / Teo, Swee-Guan / Chan, Koo-Hui / Tan, Huay-Cheem / Low, Adrian F. ·National University Heart Centre, Singapore, Singapore; National University Health System, Singapore. ·Int J Cardiol · Pubmed #23290080.

ABSTRACT: -- No abstract --