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Coronary Artery Disease: HELP
Articles by Axel Diederichsen
Based on 5 articles published since 2010
(Why 5 articles?)
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Between 2010 and 2020, Axel Diederichsen wrote the following 5 articles about Coronary Artery Disease.
 
+ Citations + Abstracts
1 Article Prevalence of coronary artery calcification in a non-specific chest pain population in emergency and cardiology departments compared with the background population: a prospective cohort study in Southern Denmark with 12-month follow-up of cardiac endpoints. 2018

Ilangkovan, Nivethitha / Mogensen, Christian Backer / Mickley, Hans / Lassen, Annmarie Touborg / Lambrechtsen, Jess / Sand, Niels Peter Ronnow / Albiniussen, Rasmus / Byg, Jørgen / Steffensen, Flemming Hald / Grønhøj, Mette Hjortdal / Diederichsen, Axel. ·Cardiology Department, Hospital of Southern Denmark, Aabenraa, Denmark. · Emergency Department, Hospital of Southern Denmark, Aabenraa, Denmark. · Cardiology Department, Odense University Hospital, Odense, Denmark. · Emergency Department, Odense University Hospital, Odense, Denmark. · Medical Department, Svendborg Hospital, Svendborg, Denmark. · Cardiology Department, Esbjerg Hiospital, Esbjerg, Denmark. · Cardiology Department, Vejle Hospital, Vejle, Denmark. ·BMJ Open · Pubmed #29502085.

ABSTRACT: OBJECTIVES: To examine and compare the prevalence of coronary artery calcification (CAC) and the frequency of cardiac events in a background population and a cohort of patients with non-specific chest pain (NSCP) who present to an emergency or cardiology department and are discharged without an obvious reason for their symptom. DESIGN: A double-blinded, prospective, observational cohort study that measures both CT-determined CAC scores and cardiac events after 1 year of follow-up. SETTING: Emergency and cardiology departments in the Region of Southern Denmark. SUBJECTS: In total, 229 patients with NSCP were compared with 722 patients from a background comparator population. MAIN OUTCOMES MEASURES: Prevalence of CAC and incidence of unstable angina (UAP), acute myocardial infarction (MI), ventricular tachycardia (VT), coronary revascularisation and cardiac-related mortality 1 year after index contact. RESULTS: There was no significant difference in the prevalence of CAC (OR 0.9 (95% CI 0.6 to 1.3), P=0.546) or the frequency of cardiac endpoints (P=0.64) between the studied groups. When compared with the background population, the OR for patients with NSCP for a CAC >100 Agatston units (AU) was 1.0 (95% CI 0.6 to 1.5), P=0.826. During 1 year of follow-up, two (0.9%) patients with NSCP underwent cardiac revascularisation, while none experienced UAP, MI, VT or death. In the background population, four (0.6%) participants experienced a clinical cardiac endpoint; two had an MI, one had VT and one had a cardiac-related death. CONCLUSION: The prevalence of CAC (CAC >0 AU) among patients with NSCP is comparable to a background population and there is a low risk of a cardiac event in the first year after discharge. A CAC study does not provide notable clinical utility for risk-stratifying patients with NSCP. TRIAL REGISTRATION NUMBER: NCT02422316; Pre-results.

2 Article CT-Detected Growth of Coronary Artery Calcification in Asymptomatic Middle-Aged Subjects and Association With 15 Biomarkers. 2017

Diederichsen, Søren Zöga / Grønhøj, Mette Hjortdal / Mickley, Hans / Gerke, Oke / Steffensen, Flemming Hald / Lambrechtsen, Jess / Rønnow Sand, Niels Peter / Rasmussen, Lars Melholt / Olsen, Michael Hecht / Diederichsen, Axel. ·Department of Cardiology, Rigshospitalet, Copenhagen University Hospital, Blegdamsvej, Copenhagen, Denmark. Electronic address: Soeren.Zoega.Diederichsen@regionh.dk. · Department of Cardiology, Odense University Hospital, Odense, Denmark; Centre for Individualized Medicine in Arterial Diseases, Odense University Hospital, Odense, Denmark. · Department of Cardiology, Odense University Hospital, Odense, Denmark. · Department of Nuclear Medicine, Odense University Hospital, Odense, Denmark; Centre of Health Economics Research, University of Southern Denmark, Odense, Denmark. · Department of Cardiology, Sygehus Lillebælt Vejle, Vejle, Denmark. · Department of Cardiology, Svendborg Hospital, Svendborg, Denmark. · Department of Cardiology, Hospital of South West Denmark, Esbjerg, Denmark; Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark. · Centre for Individualized Medicine in Arterial Diseases, Odense University Hospital, Odense, Denmark; Department of Clinical Biochemistry and Pharmacology, Odense University Hospital, Odense, Denmark; Cardiovascular Centre of Excellence, University of Southern Denmark, Odense, Denmark. · Centre for Individualized Medicine in Arterial Diseases, Odense University Hospital, Odense, Denmark; Cardiovascular Centre of Excellence, University of Southern Denmark, Odense, Denmark; Cardiology Section, Department of Internal Medicine, Holbæk Hospital, Holbæk, Denmark. · Department of Cardiology, Odense University Hospital, Odense, Denmark; Centre for Individualized Medicine in Arterial Diseases, Odense University Hospital, Odense, Denmark; Cardiovascular Centre of Excellence, University of Southern Denmark, Odense, Denmark. ·JACC Cardiovasc Imaging · Pubmed #28797406.

ABSTRACT: OBJECTIVES: This study sought to determine the incidence and progression of coronary artery calcification (CAC) in asymptomatic middle-aged subjects and to evaluate the value of a broad panel of biomarkers in the prediction of CAC growth. BACKGROUND: CAC continues to be a major risk factor, but the value of biochemical markers in predicting CAC incidence and progression remains unresolved. METHODS: At baseline, 1,227 men and women underwent traditional risk assessment and a computed tomography (CT) scan to determine the CAC score. Biomarkers of calcium-phosphate metabolism (calcium, phosphate, vitamin D RESULTS: A total of 1,006 participants underwent a CT scan after 5 years. Among the 562 participants with a baseline CAC score of 0, 189 (34%) had incident CAC, whereas 214 (48%) of the 444 participants with baseline CAC score >0 had significant progression (>15% annual increase in CAC score). In the multivariate models (n = 1,006), age, sex, hypertension, diabetes, dyslipidemia, and smoking were associated with ΔCAC, whereas the strongest predictor was baseline CAC score. Low-density lipoprotein and total cholesterol levels were independently associated with CAC incidence (n = 562; incidence rate ratio [IRR]: 1.47; 95% confidence interval [CI]: 1.05 to 2.05; and IRR: 1.34; 95% CI: 1.01 to 1.77, respectively), whereas phosphate level was associated with CAC progression (n = 444; IRR: 3.60; 95% CI: 1.42 to 9.11). CONCLUSIONS: In this prospective study, a large part of participants had incident CAC or progression of prevalent CAC at 5 years of follow-up. Low-density lipoprotein and total cholesterol were associated with CAC incidence and phosphate with CAC progression, whereas 12 other biomarkers had little value.

3 Article Diabetes and male sex are key risk factor correlates of the extent of coronary artery calcification: A Euro-CCAD study. 2017

Nicoll, Rachel / Zhao, Ying / Wiklund, Urban / Diederichsen, Axel / Mickley, Hans / Ovrehus, Kristian / Zamorano, Jose / Gueret, Pascal / Schmermund, Axel / Maffei, Erica / Cademartiri, Filippo / Budoff, Matt / Henein, Michael. ·Department of Public Health and Clinical Medicine, Umeå University and Heart Centre, Umeå, Sweden. · Department of Ultrasound, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. · Department of Radiation Sciences, Biomedical Engineering, Umea University, Umeå, Sweden. · Department of Cardiology, Odense University Hospital, Denmark. · Department of Cardiology, Odense University Hospital, Denmark; Vejle Hospital, Vejle, Denmark. · University Alcala, Hospital Ramon y Cajal, Madrid, Spain. · University Hospital Henri Mondor, Creteil, Paris, France. · Bethanien Hospital, Frankfurt, Germany. · Centre de Recherche & Department of Radiology, Montréal Heart Institute/Université de Montréal, Montréal, QC, Canada. · Centre de Recherche & Department of Radiology, Montréal Heart Institute/Université de Montréal, Montréal, QC, Canada; Department of Radiology, Erasmus Medical Center University, Rotterdam, the Netherlands. · Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA, USA. · Department of Public Health and Clinical Medicine, Umeå University and Heart Centre, Umeå, Sweden. Electronic address: michael.henein@umu.se. ·J Diabetes Complications · Pubmed #28499962.

ABSTRACT: BACKGROUND AND AIMS: Although much has been written about the conventional cardiovascular risk factor correlates of the extent of coronary artery calcification (CAC), few studies have been carried out on symptomatic patients. This paper assesses the potential ability of risk factors to associate with an increasing CAC score. METHODS: From the European Calcific Coronary Artery Disease (Euro-CCAD) cohort, we retrospectively investigated 6309 symptomatic patients, 62% male, from Denmark, France, Germany, Italy, Spain and the USA. All had conventional cardiovascular risk factor assessment and CT scanning for CAC scoring. RESULTS: Among all patients, male sex (OR = 4.85, p<0.001) and diabetes (OR = 2.36, p<0.001) were the most important risk factors of CAC extent, with age, hypertension, dyslipidemia and smoking also showing a relationship. Among patients with CAC, age, diabetes, hypertension and dyslipidemia were associated with an increasing CAC score in males and females, with diabetes being the strongest dichotomous risk factor (p<0.001 for both). These results were echoed in quantile regression, where diabetes was consistently the most important correlate with CAC extent in every quantile in both males and females. To a lesser extent, hypertension and dyslipidemia were also associated in the high CAC quantiles and the low CAC quantiles respectively. CONCLUSION: In addition to age and male sex in the total population, diabetes is the most important correlate of CAC extent in both sexes.

4 Article Prognostic assessment of stable coronary artery disease as determined by coronary computed tomography angiography: a Danish multicentre cohort study. 2017

Nielsen, Lene H / Bøtker, Hans Erik / Sørensen, Henrik T / Schmidt, Morten / Pedersen, Lars / Sand, Niels Peter / Jensen, Jesper M / Steffensen, Flemming H / Tilsted, Hans Henrik / Bøttcher, Morten / Diederichsen, Axel / Lambrechtsen, Jess / Kristensen, Lone D / Øvrehus, Kristian A / Mickley, Hans / Munkholm, Henrik / Gøtzsche, Ole / Husain, Majed / Knudsen, Lars L / Nørgaard, Bjarne L. ·Department of Cardiology, Lillebaelt Hospital-Vejle, Kabbeltoft 25, DK-7100 Vejle, Denmark. · Department of Cardiology, Aarhus University Hospital, Aarhus, Denmark. · Department of Clinical Epidemiology, Aarhus University Hospital, Aarhus, Denmark. · Department of Cardiology, Hospital of South West Jutland, Esbjerg, Denmark. · Department of Cardiology, Aalborg University Hospital, Aalborg, Denmark. · Department of Cardiology, Regional Hospital Herning, Herning, Denmark. · Department of Cardiology, Odense University Hospital, Denmark. · Department of Cardiology, Svendborg Hospital, Denmark. · Department of Cardiology, Regional Hospital Silkeborg, Silkeborg, Denmark. ·Eur Heart J · Pubmed #27941018.

ABSTRACT: Aims: To examine the 3.5 year prognosis of stable coronary artery disease (CAD) as assessed by coronary computed tomography angiography (CCTA) in real-world clinical practice, overall and within subgroups of patients according to age, sex, and comorbidity. Methods and results: This cohort study included 16,949 patients (median age 57 years; 57% women) with new-onset symptoms suggestive of CAD, who underwent CCTA between January 2008 and December 2012. The endpoint was a composite of late coronary revascularization procedure >90 days after CCTA, myocardial infarction, and all-cause death. The Kaplan-Meier estimator was used to compute 91 day to 3.5 year risk according to the CAD severity. Comparisons between patients with and without CAD were based on Cox-regression adjusted for age, sex, comorbidity, cardiovascular risk factors, concomitant cardiac medications, and post-CCTA treatment within 90 days. The composite endpoint occurred in 486 patients. Risk of the composite endpoint was 1.5% for patients without CAD, 6.8% for obstructive CAD, and 15% for three-vessel/left main disease. Compared with patients without CAD, higher relative risk of the composite endpoint was observed for non-obstructive CAD [hazard ratio (HR): 1.28; 95% confidence interval (CI): 1.01-1.63], obstructive one-vessel CAD (HR: 1.83; 95% CI: 1.37-2.44), two-vessel CAD (HR: 2.97; 95% CI: 2.09-4.22), and three-vessel/left main CAD (HR: 4.41; 95% CI :2.90-6.69). The results were consistent in strata of age, sex, and comorbidity. Conclusion: Coronary artery disease determined by CCTA in real-world practice predicts the 3.5 year composite risk of late revascularization, myocardial infarction, and all-cause death across different groups of age, sex, or comorbidity burden.

5 Minor [Calcium screening in asymptomatic persons]. 2010

Diederichsen, Axel / Mickley, Hans. · ·Ugeskr Laeger · Pubmed #20429149.

ABSTRACT: -- No abstract --