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Coronary Artery Disease: HELP
Articles by Majid Kalani
Based on 3 articles published since 2010
(Why 3 articles?)

Between 2010 and 2020, Majid Kalani wrote the following 3 articles about Coronary Artery Disease.
+ Citations + Abstracts
1 Article Kidney function is associated with short-term, mid-term and long-term clinical outcome after coronary angiography and intervention. 2018

Panayiotou, Andrie G / Spaak, Jonas / Kalani, Majid. ·a Cyprus International Institute for Environmental and Public Health , Cyprus University of Technology , Limassol , Cyprus. · b Karolinska Institutet, Department of Clinical Sciences , Danderyd University Hospital , Stockholm , Sweden. ·Acta Cardiol · Pubmed #29082834.

ABSTRACT: BACKGROUND: Patients with kidney dysfunction are at risk of developing ischaemic heart disease. We investigated the association between eGFR and early-, mid- and long-term clinical outcome in patients undergoing coronary angiography and intervention. METHODS: Retrospective study on 4968 patients with complete data on eGFR, 65% male and aged 32-80 years, admitted to Danderyd University Hospital, Stockholm, Sweden for coronary angiography and intervention from 2006 to 2008. Data were censored at 0-30 days, 31-365 days and 366-1825 days of follow-up. RESULTS: Baseline eGFR was strongly associated with all-cause mortality at all three time periods studied with each 10 ml/min per 1.73 m CONCLUSIONS: We report a strong association between kidney function and all-cause mortality at both early, mid- and long-term follow-up in patients undergoing coronary angiography and intervention, with eGFR significantly associated with MI-related mortality after one month of follow-up. Kidney function was also shown to be associated with risk for re-vascularisation at one month, indicating mostly procedural-related risk and with new MI at mid-term follow-up. Further research is warranted to explore the mechanisms linking kidney function and cardiovascular disease to improve both the short- and long-term care of these patients.

2 Article Severely impaired microvascular reactivity in diabetic patients with an acute coronary syndrome. 2016

Östlund Papadogeorgos, Nikolaos / Jörneskog, Gun / Bengtsson, Mattias / Kahan, Thomas / Kalani, Majid. ·Dept of Cardiology, Danderyd University Hospital Corp, 182 88, Stockholm, Sweden. nikolaos.ostlund-papadogeorgos@ds.se. · Department of Clinical Sciences, Karolinska Institutet, Danderyd Hospital, Stockholm, Sweden. ·Cardiovasc Diabetol · Pubmed #27095564.

ABSTRACT: BACKGROUND: Microvascular function is impaired in patients with stable coronary artery disease. The aim was to study microvascular function in patients with diabetes and acute coronary syndrome (ACS). METHODS: Microvascular function was evaluated in 83 patients by laser Doppler fluxmetry (LDF) [PU; perfusion unit, median (interquartile range)] measuring resting LDF and peak LDF following a six min heating of the skin to 44 °C at the foot, respectively. All patients with ACS and without previously known diabetes underwent oral glucose tolerance test. Thirty-nine patients with type 2 diabetes mellitus free from coronary artery disease served as controls. RESULTS: Peak LDF was significantly (P = 0.03) lower in patients with ACS and diabetes (n = 22; 72 (52)) and diabetes without coronary artery disease (n = 39; 69 (51)) as compared to patients with ACS without diabetes (n = 46; 97 (60)), and patients without ACS (n = 15; 140 (121)), respectively. Patients with ACS (n = 68) had significantly (P = 0.04) lower peak LDF (92 (49)) as compared to patients without ACS (n = 15) (140 (121)). CONCLUSION: Microvascular reactivity is severely impaired in patients with diabetes and ACS. Diabetes has a major influence on microvascular function in patients with coronary artery disease.

3 Article Comparison of venous and arterial blood sampling for the assessment of platelet aggregation with whole blood impedance aggregometry. 2011

Kafian, Sam / Mobarrez, Fariborz / Kalani, Majid / Wallén, Håkan / Samad, Bassem A. ·Department of Clinical Sciences, Danderyd Hospital, Division of Cardiovascular Medicine, Karolinska Institutet, Stockholm, Sweden. ·Scand J Clin Lab Invest · Pubmed #21870998.

ABSTRACT: Platelet monitoring is presently under evaluation in the clinic as a tool to improve antiplatelet treatment in patients with coronary artery disease (CAD). Measuring platelet function has, however, many inherent problems. It is important not only to evaluate the method used, but also to evaluate and standardize sampling and sample handling. As platelet monitoring is often performed in connection to coronary angiography and percutaneous coronary interventions, arterial sampling may be more convenient. However, in the outpatient follow-up setting venous sampling is, for obvious reasons, more practical and convenient. In the present study we compared platelet aggregation in blood collected from the arterial sheath to blood collected from the antecubital vein using multiple electrode aggregometry in whole blood in 28 patients with CAD. We found that sampling from artery and vein give similar data and that an identical number of patients with insufficient antiplatelet responses ('low responders' to aspirin and clopidogrel, respectively, according to predefined criteria) were detected with respect to adenosine diphosphate induced and arachidonic-acid induced aggregation. Thus both arterial and venous blood samples can be used in the monitoring of platelet function when multiple electrode aggregometry is applied to detect 'low responders'.