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Coronary Artery Disease: HELP
Articles by Jonathon A. Leipsic
Based on 115 articles published since 2008
||||

Between 2008 and 2019, J. A. Leipsic wrote the following 115 articles about Coronary Artery Disease.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5
1 Guideline ACR Appropriateness Criteria 2018

Anonymous2701124 / Shah, Amar B / Kirsch, Jacobo / Bolen, Michael A / Batlle, Juan C / Brown, Richard K J / Eberhardt, Robert T / Hurwitz, Lynne M / Inacio, Joao R / Jin, Jill O / Krishnamurthy, Rajesh / Leipsic, Jonathon A / Rajiah, Prabhakar / Singh, Satinder P / White, Richard D / Zimmerman, Stefan L / Abbara, Suhny. ·Westchester Medical Center, Valhalla, New York. Electronic address: ashah27@northwell.edu. · Panel Chair, Cleveland Clinic Florida, Weston, Florida. · Panel Vice-Chair, Cleveland Clinic, Cleveland, Ohio. · Miami Cardiac and Vascular Institute and Baptist Health of South Florida, Miami, Florida. · University of Michigan Health System, Ann Arbor, Michigan. · Boston University School of Medicine, Boston, Massachusetts; American College of Cardiology. · Duke University Medical Center, Durham, North Carolina. · The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada. · Northwestern University Feinberg School of Medicine, Chicago, Illinois; American College of Physicians. · Nationwide Children's Hospital, Columbus, Ohio. · St. Paul's Hospital, Vancouver, British Columbia, Canada. · UT Southwestern Medical Center, Dallas, Texas. · University of Alabama at Birmingham, Birmingham, Alabama. · The Ohio State University Wexner Medical Center, Columbus, Ohio. · Johns Hopkins Medical Institute, Baltimore, Maryland. · Specialty Chair, UT Southwestern Medical Center, Dallas, Texas. ·J Am Coll Radiol · Pubmed #30392597.

ABSTRACT: Chronic chest pain (CCP) of a cardiac etiology is a common clinical problem. The diagnosis and classification of the case of chest pain has rapidly evolved providing the clinician with multiple cardiac imaging strategies. Though scintigraphy and rest echocardiography remain as appropriate imaging tools in the diagnostic evaluation, new technology is available. Current evidence supports the use of alternative imaging tests such as coronary computed tomography angiography (CCTA), cardiac MRI (CMRI), or Rb-82 PET/CT. Since multiple imaging modalities are available to the clinician, the most appropriate noninvasive imaging strategy will be based upon the patient's clinical presentation and clinical status. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.

2 Guideline CAC-DRS: Coronary Artery Calcium Data and Reporting System. An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). 2018

Hecht, Harvey S / Blaha, Michael J / Kazerooni, Ella A / Cury, Ricardo C / Budoff, Matt / Leipsic, Jonathon / Shaw, Leslee. ·Division of Cardiology, Icahn School of Medicine at Mount Sinai, and Mount Sinai St. Luke's Medical Center, New York, NY, United States. Electronic address: harvey.hecht@mountsinai.org. · The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, United States. · Division of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, United States. · Miami Cardiac and Vascular Institute, Baptist Hospital of Miami, 8900 N Kendall Drive, Miami, FL 33176, United States. · Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, United States. · Department of Medicine and Radiology, University of British Columbia, Vancouver, Canada. · Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States. ·J Cardiovasc Comput Tomogr · Pubmed #29793848.

ABSTRACT: The goal of CAC-DRS: Coronary Artery Calcium Data and Reporting System is to create a standardized method to communicate findings of CAC scanning on all noncontrast CT scans, irrespective of the indication, in order to facilitate clinical decision-making, with recommendations for subsequent patient management. The CAC-DRS classification is applied on a per-patient basis and represents the total calcium score and the number of involved arteries. General recommendations are provided for further management of patients with different degrees of calcified plaque burden based on CAC-DRS classification. In addition, CAC-DRS will provide a framework of standardization that may benefit quality assurance and tracking patient outcomes with the potential to ultimately result in improved quality of care.

3 Guideline Clinical indications for coronary artery calcium scoring in asymptomatic patients: Expert consensus statement from the Society of Cardiovascular Computed Tomography. 2017

Hecht, Harvey / Blaha, Michael J / Berman, Daniel S / Nasir, Khurram / Budoff, Matthew / Leipsic, Jonathon / Blankstein, Ron / Narula, Jagat / Rumberger, John / Shaw, Leslee J. ·Division of Cardiology, Icahn School of Medicine at Mount Sinai, Mount Sinai St. Luke's Medical Center, New York, NY, USA. Electronic address: hhecht@aol.com. · The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA. · Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. · Miami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA. · Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. · Department of Medicine and Radiology, University of British Columbia, Vancouver, Canada. · Non-Invasive Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. · Division of Cardiology, Icahn School of Medicine at Mount Sinai, Mount Sinai St. Luke's Medical Center, New York, NY, USA. · The Princeton Longevity Center, Princeton, NJ, USA. · Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. ·J Cardiovasc Comput Tomogr · Pubmed #28283309.

ABSTRACT: This expert consensus statement summarizes the available data regarding the prognostic value of CAC in the asymptomatic population and its ability to refine individual risk prediction, addresses the limitations identified in the current traditional risk factor-based treatment strategies recommended by the 2013 ACC/AHA Prevention guidelines including use of the Pooled Cohort Equations (PCE), and the US Preventive Services Task Force (USPSTF) Recommendation Statement for Statin Use for the Primary Prevention of Cardiovascular Disease in Adults. It provides CAC based treatment recommendations both within the context of the shared decision making model espoused by the 2013 ACC/AHA Prevention guidelines and independent of these guidelines.

4 Guideline SCCT guidelines for the performance and acquisition of coronary computed tomographic angiography: A report of the society of Cardiovascular Computed Tomography Guidelines Committee: Endorsed by the North American Society for Cardiovascular Imaging (NASCI). 2016

Abbara, Suhny / Blanke, Philipp / Maroules, Christopher D / Cheezum, Michael / Choi, Andrew D / Han, B Kelly / Marwan, Mohamed / Naoum, Chris / Norgaard, Bjarne L / Rubinshtein, Ronen / Schoenhagen, Paul / Villines, Todd / Leipsic, Jonathon. ·University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address: Suhny.Abbara@UTSouthwestern.edu. · Department of Radiology and Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. · University of Texas Southwestern Medical Center, Dallas, TX, United States. · Cardiology Service Ft. Belvoir Community Hospital, Ft. Belvoir, VA, United States. · Division of Cardiology and Department of Radiology, The George Washington University School of Medicine, Washington DC, United States. · Minneapolis Heart Institute and Children's Heart Clinic, Minneapolis, MN, United States. · Cardiology Department, University Hospital, Erlangen, Germany. · Concord Hospital, The University of Sydney, Sydney, Australia. · Department of Cardiology B, Aarhus University Hospital-Skejby, Aarhus N, Denmark. · Lady Davis Carmel Medical Center & Rappaport School of Medicine- Technion- IIT, Haifa, Israel. · Cardiovascular Imaging, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, United States. · Walter Reed National Military Medical Center, Bethesda, MD, United States. ·J Cardiovasc Comput Tomogr · Pubmed #27780758.

ABSTRACT: In response to recent technological advancements in acquisition techniques as well as a growing body of evidence regarding the optimal performance of coronary computed tomography angiography (coronary CTA), the Society of Cardiovascular Computed Tomography Guidelines Committee has produced this update to its previously established 2009 "Guidelines for the Performance of Coronary CTA" (1). The purpose of this document is to provide standards meant to ensure reliable practice methods and quality outcomes based on the best available data in order to improve the diagnostic care of patients. Society of Cardiovascular Computed Tomography Guidelines for the Interpretation is published separately (2). The Society of Cardiovascular Computed Tomography Guidelines Committee ensures compliance with all existing standards for the declaration of conflict of interest by all authors and reviewers for the purpose ofclarity and transparency.

5 Guideline Coronary Artery Disease - Reporting and Data System (CAD-RADS): An Expert Consensus Document of SCCT, ACR and NASCI: Endorsed by the ACC. 2016

Cury, Ricardo C / Abbara, Suhny / Achenbach, Stephan / Agatston, Arthur / Berman, Daniel S / Budoff, Matthew J / Dill, Karin E / Jacobs, Jill E / Maroules, Christopher D / Rubin, Geoffrey D / Rybicki, Frank J / Schoepf, U Joseph / Shaw, Leslee J / Stillman, Arthur E / White, Charles S / Woodard, Pamela K / Leipsic, Jonathon A. · ·JACC Cardiovasc Imaging · Pubmed #27609151.

ABSTRACT: The intent of CAD-RADS - Coronary Artery Disease Reporting and Data System is to create a standardized method to communicate findings of coronary CT angiography (coronary CTA) in order to facilitate decision-making regarding further patient management. The suggested CAD-RADS classification is applied on a per-patient basis and represents the highest-grade coronary artery lesion documented by coronary CTA. It ranges from CAD-RADS 0 (Zero) for the complete absence of stenosis and plaque to CAD-RADS 5 for the presence of at least one totally occluded coronary artery and should always be interpreted in conjunction with the impression found in the report. Specific recommendations are provided for further management of patients with stable or acute chest pain based on the CAD-RADS classification. The main goal of CAD-RADS is to standardize reporting of coronary CTA results and to facilitate communication of test results to referring physicians along with suggestions for subsequent patient management. In addition, CAD-RADS will provide a framework of standardization that may benefit education, research, peer-review and quality assurance with the potential to ultimately result in improved quality of care.

6 Guideline CAD-RADS(TM) Coronary Artery Disease - Reporting and Data System. An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT), the American College of Radiology (ACR) and the North American Society for Cardiovascular Imaging (NASCI). Endorsed by the American College of Cardiology. 2016

Cury, Ricardo C / Abbara, Suhny / Achenbach, Stephan / Agatston, Arthur / Berman, Daniel S / Budoff, Matthew J / Dill, Karin E / Jacobs, Jill E / Maroules, Christopher D / Rubin, Geoffrey D / Rybicki, Frank J / Schoepf, U Joseph / Shaw, Leslee J / Stillman, Arthur E / White, Charles S / Woodard, Pamela K / Leipsic, Jonathon A. ·Miami Cardiac and Vascular Institute, Baptist Hospital of Miami, 8900 N Kendall Drive, Miami, FL, 33176, United States. Electronic address: rcury@baptisthealth.net. · Department of Radiology, 5323 Harry Hines Blvd, Dallas, TX, 75390, United States. Electronic address: Suhny.Abbara@UTSouthwestern.edu. · Friedrich-Alexander-Universität, Erlangen-Nürnberg, Department of Cardiology, Ulmenweg 18, 90154, Erlangen, Germany. Electronic address: Stephan.Achenbach@uk-erlangen.de. · Baptist Health Medical Grp, 1691 Michigan Avenue, Miami, FL, 33139, United States. Electronic address: ArthurSAg@baptisthealth.net. · Cedars-Sinai Med Center, 8700 Beverly Boulevard, Taper Building, Rm 1258, Los Angeles, CA, 90048, United States. Electronic address: bermand@cshs.org. · 1124 W. Carson Street, Torrance, CA, 90502, United States. Electronic address: mbudoff@labiomed.org. · 5841 South Maryland Ave, MC2026, Chicago, IL, 60637, United States. Electronic address: kdill@radiology.bsd.uchicago.edu. · 550 First Avenue, New York, NY, 10016, United States. Electronic address: jill.jacobs@nyumc.org. · Department of Radiology, 5323 Harry Hines Blvd, Dallas, TX, 75390, United States. Electronic address: christopher.maroules@gmail.com. · 2400 Pratt Street, Room 8020, DCRI Box 17969, Durham, NC, 27715, United States. Electronic address: grubin@duke.edu. · The Ottawa Hospital General Campus, 501 Smyth Rd, Ottawa, ON, CA K1H 8L6, Canada. Electronic address: frybicki@toh.on.ca. · 25 Courtenay Dr., Charleston, SC, 29425, United States. Electronic address: schoepf@musc.edu. · 1256 Briarcliff Rd. NE, Rm 529, Atlanta, GA, 30324, United States. Electronic address: lshaw3@emory.edu. · 1364 Clifton Road, NE, Atlanta, GA, 30322, United States. Electronic address: aestill@emory.edu. · University of Maryland, 22 S. Greene St., Baltimore, MD, 21201, United States. Electronic address: cwhite@umm.edu. · Mallinckrodt Instit of Radiology, 510 S Kingshighway Blvd, St. Louis, MO, 63110, United States. Electronic address: woodardp@mir.wustl.edu. · Department of Radiology|St. Paul's Hospital, 2nd Floor, Providence Building, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, United States. Electronic address: jleipsic@providencehealth.bc.ca. ·J Cardiovasc Comput Tomogr · Pubmed #27318587.

ABSTRACT: The intent of CAD-RADS - Coronary Artery Disease Reporting and Data System is to create a standardized method to communicate findings of coronary CT angiography (coronary CTA) in order to facilitate decision-making regarding further patient management. The suggested CAD-RADS classification is applied on a per-patient basis and represents the highest-grade coronary artery lesion documented by coronary CTA. It ranges from CAD-RADS 0 (Zero) for the complete absence of stenosis and plaque to CAD-RADS 5 for the presence of at least one totally occluded coronary artery and should always be interpreted in conjunction with the impression found in the report. Specific recommendations are provided for further management of patients with stable or acute chest pain based on the CAD-RADS classification. The main goal of CAD-RADS is to standardize reporting of coronary CTA results and to facilitate communication of test results to referring physicians along with suggestions for subsequent patient management. In addition, CAD-RADS will provide a framework of standardization that may benefit education, research, peer-review and quality assurance with the potential to ultimately result in improved quality of care.

7 Guideline Canadian Cardiovascular Society position statement on the management of thoracic aortic disease. 2014

Boodhwani, Munir / Andelfinger, Gregor / Leipsic, Jonathon / Lindsay, Thomas / McMurtry, M Sean / Therrien, Judith / Siu, Samuel C / Anonymous6800795. ·Division of Cardiac Surgery, University of Ottawa Heart Institute, Ottawa, Ontario, Canada. Electronic address: mboodhwani@ottawaheart.ca. · Department of Pediatrics, University of Montreal, Montreal, Québec, Canada. · Department of Radiology, University of British Colombia, Vancouver, British Colombia, Canada. · Division of Vascular Surgery, University Health Network, Toronto, Ontario, Canada. · Division of Cardiology, University of Alberta, Edmonton, Alberta, Canada. · Division of Cardiology, McGill University, Montreal, Québec, Canada. · Division of Cardiology, Western University, London, Ontario, Canada. ·Can J Cardiol · Pubmed #24882528.

ABSTRACT: This Canadian Cardiovascular Society position statement aims to provide succinct perspectives on key issues in the management of thoracic aortic disease (TAD). This document is not a comprehensive overview of TAD and important elements of the epidemiology, presentation, diagnosis, and management of acute aortic syndromes are deliberately not discussed; readers are referred to the 2010 guidelines published by the American Heart Association, American College of Cardiology, American Association for Thoracic Surgery, and other stakeholders. Rather, this document is a practical guide for clinicians managing adult patients with TAD. Topics covered include size thresholds for surgical intervention, emerging therapies, imaging modalities, medical and lifestyle management, and genetics of TAD. The primary panel consisted of experts from a variety of disciplines that are essential for comprehensive management of TAD patients. The methodology involved a focused literature review with an emphasis on updates since 2010 and the use of Grading of Recommendations Assessment, Development, and Evaluation methodology to arrive at specific recommendations. The final document then underwent review by a secondary panel. This document aims to provide recommendations for most patients and situations. However, the ultimate judgement regarding the management of any individual patients should be made by their health care team.

8 Editorial Coronary Computed Tomographic Angiography - The evidence dominates! 2017

Shaw, Leslee J / Villines, Todd / Blankstein, Ron / Abbara, Suhny / Weigold, Guy / Slim, Ahmad / Leipsic, Jonathon. ·Emory University School of Medicine, Atlanta, Georgia. Electronic address: lshaw3@emory.edu. · Walter Reed Medical Center, Bethesda, MD, United States. · Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. · University of Texas Southwestern Medical Center, Dallas, TX, United States. · MedStar Washington Hospital Center, Washington DC, United States. · Tulane University School of Medicine, New Orleans, LA, United States. · The University of British Columbia, Vancouver, BC, Canada. ·J Cardiovasc Comput Tomogr · Pubmed #28017553.

ABSTRACT: -- No abstract --

9 Editorial Developing a Deeper Understanding of Sex Differences in the Diagnostic Performance of Computed Tomographic Perfusion Imaging Toward a More Personalized Approach. 2016

Kueh, Shaw Hua Anthony / Sellers, Stephanie / Leipsic, Jonathon. ·From the Department of Radiology (S.H.K., S.S., J.L.) and Department of Cardiology (J.L.), University of British Columbia, Vancouver, Canada. · From the Department of Radiology (S.H.K., S.S., J.L.) and Department of Cardiology (J.L.), University of British Columbia, Vancouver, Canada. jleipsic@providencehealth.bc.ca. ·Circ Cardiovasc Imaging · Pubmed #27811152.

ABSTRACT: -- No abstract --

10 Editorial Diagnostic Algorithms for Stable Chest Pain: From Opinion to Science Lessons From PROMISE. 2016

Leipsic, Jonathon / Naoum, Christopher / Blanke, Philipp. ·Department of Medical Imaging and Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: jleipsic@providencehealth.bc.ca. · Department of Cardiology, Concord Hospital, The University of Sydney, Sydney, Australia. · Department of Medical Imaging and Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. ·J Am Coll Cardiol · Pubmed #27256832.

ABSTRACT: -- No abstract --

11 Editorial Change is the law of life. And those who look only to the past or present are certain to miss the future. - John F. Kennedy. 2016

Leipsic, Jonathon A. ·Canada Research Chair, Advanced Cardiac Imaging and Vice Chairman of Radiology, University of British Columbia, Canada. Electronic address: jleipsic@providencehealth.bc.ca. ·J Cardiovasc Comput Tomogr · Pubmed #27145696.

ABSTRACT: -- No abstract --

12 Editorial President's Page. 2015

Leipsic, Jonathon A. ·Canada Research Chair, Advanced Cardiac Imaging and Vice Chairman of Radiology, University of British Columbia, Canada. Electronic address: jleipsic@providencehealth.bc.ca. ·J Cardiovasc Comput Tomogr · Pubmed #26411313.

ABSTRACT: -- No abstract --

13 Editorial Cardiac CT in asymptomatic diabetes mellitus: role of non-invasive atherosclerosis imaging in high-risk asymptomatic individuals. 2015

Cademartiri, Filippo / Maffei, Erica / Nistri, Stefano / Leipsic, Jonathon. ·Department of Radiology, Erasmus Medical Center University, Rotterdam, The Netherlands filippocademartiri@gmail.com. · Department of Radiology, Giovanni XXIII Clinic, Monastier di Treviso, Italy. · Department of Cardiology, CMSR, Altavilla Vicentina, Italy. · Department of Radiology, University of British Columbia, Vancouver, Canada. ·Eur Heart J Cardiovasc Imaging · Pubmed #26041310.

ABSTRACT: -- No abstract --

14 Editorial Expert opinion: How and when to perform CT myocardial perfusion imaging. 2015

Boiselle, Phillip M / Choe, Yeon Hyeon / Leipsic, Jonathon / Pugliese, Francesca / Schoepf, U Joseph / Vliegenthart, Rozemarijn. · ·J Thorac Imaging · Pubmed #25844977.

ABSTRACT: -- No abstract --

15 Editorial Is atherosclerotic heart disease in COPD a distinct phenotype? 2011

Man, S F Paul / Leipsic, Jonathon A / Man, Jonathan P / Sin, Donald D. ·Respirology Division, University of British Columbia, Vancouver, BC, Canada; St. Paul's Hospital, Vancouver, BC, Canada; University of British Columbia Institute for Heart + Lung Health, Vancouver, BC, Canada. Electronic address: pman@providencehealth.bc.ca. · Department of Radiology, University of British Columbia, Vancouver, BC, Canada; St. Paul's Hospital, Vancouver, BC, Canada. · Division of Cardiology, University of British Columbia, Vancouver, BC, Canada; St. Paul's Hospital, Vancouver, BC, Canada. · Respirology Division, University of British Columbia, Vancouver, BC, Canada; St. Paul's Hospital, Vancouver, BC, Canada; University of British Columbia Institute for Heart + Lung Health, Vancouver, BC, Canada. ·Chest · Pubmed #21896514.

ABSTRACT: -- No abstract --

16 Review Coronary CT Angiography Derived Fractional Flow Reserve: The Game Changer in Noninvasive Testing. 2017

Nørgaard, Bjarne Linde / Jensen, Jesper Møller / Blanke, Philipp / Sand, Niels Peter / Rabbat, Mark / Leipsic, Jonathon. ·Department Cardiology, Aarhus University Hospital, 8200, Aarhus N, Denmark. bnorgaard@dadlnet.dk. · Department Cardiology, Aarhus University Hospital, 8200, Aarhus N, Denmark. · Department of Radiology and Medicine, St. Paul´s Hospital, University of British Columbia, Vancouver, Canada. · Department Cardiology, Hospital of South West Denmark, Esbjerg, and Institute of regional Health Research, University of Southern Denmark, Esbjerg, Denmark. · Medicine and Radiology, Division of Cardiology, Loyola University Chicago, Chicago, Illinois, USA. ·Curr Cardiol Rep · Pubmed #28940026.

ABSTRACT: PURPOSE OF REVIEW: To summarize the scientific basis of CT derived fractional flow reserve (FFR

17 Review Interpreting results of coronary computed tomography angiography-derived fractional flow reserve in clinical practice. 2017

Rabbat, Mark G / Berman, Daniel S / Kern, Morton / Raff, Gilbert / Chinnaiyan, Kavitha / Koweek, Lynne / Shaw, Leslee J / Blanke, Philipp / Scherer, Markus / Jensen, Jesper M / Lesser, John / Nørgaard, Bjarne L / Pontone, Gianluca / De Bruyne, Bernard / Bax, Jeroen J / Leipsic, Jonathon. ·Department of Medicine and Radiology, Division of Cardiology, Loyola University Chicago, Chicago, IL, USA; Edward Hines Jr. Veteran's Affairs Hospital, Hines, IL, USA. Electronic address: mrabbat@lumc.edu. · Cedars-Sinai Medical Center, Department of Imaging, USA. · VA Long Beach HCS, Department of Cardiology, University of California Irvine, USA. · Beaumont Health, Department of Cardiology, USA. · Duke University, Department of Medicine and Radiology, USA. · Emory University, Department of Cardiology, USA. · St. Paul's Hospital & University of British Columbia, Department of Radiology, Canada. · Sanger Heart and Vascular Institute, Department of Cardiology, USA. · Aarhus University Hospital, Department of Cardiology, Denmark. · Minneapolis Heart Institute, USA. · Cardiologico Monzino, Department of Cardiovascular Imaging, Milan, Italy. · OLV Ziekenhuis Aalst, Cardiovascular Center Aalst, Belgium. · Leiden University Medical Center, Department of Cardiology, The Netherlands. ·J Cardiovasc Comput Tomogr · Pubmed #28666784.

ABSTRACT: The application of computational fluid dynamics to coronary computed tomography angiography allows Fractional Flow Reserve (FFR) to be calculated non-invasively (FFR

18 Review Prognostic Determinants of Coronary Atherosclerosis in Stable Ischemic Heart Disease: Anatomy, Physiology, or Morphology? 2016

Ahmadi, Amir / Stone, Gregg W / Leipsic, Jonathon / Shaw, Leslee J / Villines, Todd C / Kern, Morton J / Hecht, Harvey / Erlinge, David / Ben-Yehuda, Ori / Maehara, Akiko / Arbustini, Eloisa / Serruys, Patrick / Garcia-Garcia, Hector M / Narula, Jagat. ·From the Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, NY (A.A., H.H., J.N.) · Columbia University Medical Center, Cardiovascular Research Foundation, New York, NY (G.W.S., A.M.) · University of British Columbia, Vancouver, British Columbia, Canada (A.A., J.L.) · Emory University School of Medicine, Atlanta, GA (L.J.S.) · Walter Reed National Military Medical Center, Bethesda, MD (T.C.V.) · University of California Irvine (M.J.K.) · Lund University, Sweden (D.E.) · University of California San Diego (O.B.-Y.) · Policlinico San Matteo Pavia Fondazione, Pravia, Italy (E.A.) · Imperial College, London, United Kingdom (P.S.) · and Leesburg Regional Medical Centre, FL (H.M.G.-G.). ·Circ Res · Pubmed #27390334.

ABSTRACT: Risk stratification in patients with stable ischemic heart disease is essential to guide treatment decisions. In this regard, whether coronary anatomy, physiology, or plaque morphology is the best determinant of prognosis (and driver an effective therapeutic risk reduction) remains one of the greatest ongoing debates in cardiology. In the present report, we review the evidence for each of these characteristics and explore potential algorithms that may enable a practical diagnostic and therapeutic strategy for the management of patients with stable ischemic heart disease.

19 Review Beyond Stenosis With Fractional Flow Reserve Via Computed Tomography and Advanced Plaque Analyses for the Diagnosis of Lesion-Specific Ischemia. 2016

Cheruvu, Chaitu / Naoum, Christopher / Blanke, Philipp / Norgaard, Bjarne / Leipsic, Jonathon. ·Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada. · Department of Cardiology, Aarhus University Hospital, Aarhus Skejby, Denmark. · Department of Medicine and Radiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: jleipsic@providencehealth.bc.ca. ·Can J Cardiol · Pubmed #27032888.

ABSTRACT: In the treatment of stable coronary artery disease (CAD), the determination of stenosis severity by invasive coronary angiography (ICA) is a critical procedure, and for borderline lesions, the detection of ischemia through invasive fractional flow reserve (FFR) is the gold standard. With advances in computational fluid dynamics, FFR can now be calculated noninvasively using anatomic data from coronary computed tomographic angiography (CCTA). This technique is known as FFR

20 Review Noninvasive Fractional Flow Reserve Derived From Coronary CT Angiography: Clinical Data and Scientific Principles. 2015

Min, James K / Taylor, Charles A / Achenbach, Stephan / Koo, Bon Kwon / Leipsic, Jonathon / Nørgaard, Bjarne L / Pijls, Nico J / De Bruyne, Bernard. ·Departments of Radiology and Medicine, Weill Cornell Medical College, New York, New York; Dalio Institute of Cardiovascular Imaging, New York-Presbyterian Hospital, New York, New York. Electronic address: jkm2001@med.cornell.edu. · HeartFlow, Inc., Redwood City, California; Department of Bioengineering, Stanford University, Stanford, California. · Department of Cardiology, Erlangen University Hospital, Erlangen, Germany. · Department of Medicine, Seoul National University Hospital, Seoul, South Korea. · Department of Radiology, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. · Department of Medicine, Weill Cornell Medical Center, New York, New York; Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark. · Catharina Hospital, Eindhoven, the Netherlands. · Cardiovascular Center Aalst, OLV Hospital, Aalst, Belgium. ·JACC Cardiovasc Imaging · Pubmed #26481846.

ABSTRACT: Fractional flow reserve derived from coronary computed tomography angiography enables noninvasive assessment of the hemodynamic significance of coronary artery lesions and coupling of the anatomic severity of a coronary stenosis with its physiological effects. Since its initial demonstration of feasibility of use in humans in 2011, a significant body of clinical evidence has developed to evaluate the diagnostic performance of coronary computed tomography angiography-derived fractional flow reserve compared with an invasive fractional flow reserve reference standard. The purpose of this paper was to describe the scientific principles and to review the clinical data of this technology recently approved by the U.S. Food and Drug Administration.

21 Review Do plaques rapidly progress prior to myocardial infarction? The interplay between plaque vulnerability and progression. 2015

Ahmadi, Amir / Leipsic, Jonathon / Blankstein, Ron / Taylor, Carolyn / Hecht, Harvey / Stone, Gregg W / Narula, Jagat. ·From the Division of Cardiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.A., H.H., J.N.) · Division of Cardiology (A.A., J.L., C.T.), and Division of Radiology (J.L.), University of British Columbia, Vancouver, BC, Canada · Division of Cardiovascular Medicine, Brigham and Women Hospital, Harvard Medical School, Boston, MA (R.B.) · and Medical Center and the Cardiovascular Research Foundation, Columbia University, New York, NY (G.W.S.). ·Circ Res · Pubmed #26089367.

ABSTRACT: There is a common misperception in the cardiology community that most acute coronary events arise from ruptures of mildly stenotic plaques. This notion has emanated from multiple studies that had measured the degree of angiographic luminal narrowing in culprit plaques months to years before myocardial infarction. However, angiographic studies within 3 months before myocardial infarction, immediately after myocardial infarction with thrombus aspiration or fibrinolytic therapy, and postmortem pathological observations have all shown that culprit plaques in acute myocardial infarction are severely stenotic. Serial angiographic studies also have demonstrated a sudden rapid lesion progression before most cases of acute coronary syndromes. The possible mechanisms for such rapid plaque progression and consequent luminal obstruction include recurrent plaque rupture and healing and intraplaque neovascularization and hemorrhage with deposition of erythrocyte-derived free cholesterol. Moreover, recent intravascular and noninvasive imaging studies have demonstrated that plaques which result in coronary events have larger plaque volume and necrotic core size with greater positive vessel remodeling compared with plaques, which remain asymptomatic during several years follow-up, although these large atheromatous vulnerable plaques may angiographically seem mild. As such, it is these vulnerable plaques which are more prone to rapid plaque progression or are those in which plaque progression is more likely to become clinically evident. Therefore, in addition to characterizing plaque morphology, inflammatory activity, and severity, detection of the rate of plaque progression might identify vulnerable plaques with an increased potential for adverse outcomes.

22 Review Iterative reconstruction in cardiac CT. 2015

Naoum, Christopher / Blanke, Philipp / Leipsic, Jonathon. ·Department of Medical Imaging and Division of Cardiology, St Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6. · Department of Medical Imaging and Division of Cardiology, St Paul's Hospital, University of British Columbia, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6. Electronic address: jleipsic@providencehealth.bc.ca. ·J Cardiovasc Comput Tomogr · Pubmed #26088375.

ABSTRACT: Iterative reconstruction (IR) has the ability to reduce image noise in CT without compromising diagnostic quality, which permits a significant reduction in effective radiation dose. This been increasingly integrated into clinical CT practice over the past 7 years and has been particularly important in the field of cardiac CT with multiple vendors introducing cardiac CT-compatible IR algorithms. The following review will summarize the principles of IR algorithms, studies validating their noise- and dose-reducing abilities, and the specific applications of IR in cardiac CT.

23 Review Open issues in transcatheter aortic valve implantation. Part 1: patient selection and treatment strategy for transcatheter aortic valve implantation. 2014

Bax, Jeroen J / Delgado, Victoria / Bapat, Vinayak / Baumgartner, Helmut / Collet, Jean P / Erbel, Raimund / Hamm, Christian / Kappetein, Arie P / Leipsic, Jonathon / Leon, Martin B / MacCarthy, Philip / Piazza, Nicolo / Pibarot, Philippe / Roberts, William C / Rodés-Cabau, Josep / Serruys, Patrick W / Thomas, Martyn / Vahanian, Alec / Webb, John / Zamorano, Jose Luis / Windecker, Stephan. ·Department of Cardiology, Leiden University Medical Center, Albinusdreef 2 2300 RC, Leiden, The Netherlands j.j.bax@lumc.nl. · Department of Cardiology, Leiden University Medical Center, Albinusdreef 2 2300 RC, Leiden, The Netherlands. · Department of Cardiology and Cardiothoracic Surgery, St Thomas' Hospital, London, UK. · Division of Adult Congenital and Valvular Heart Disease, Department of Cardiovascular Medicine, University Hospital Muenster, Muenster, Germany. · Institut de Cardiologie, Groupe Hospitalier Pitié-Salpêtrière, Paris, France. · Department of Cardiology, West-German Heart Center Essen, University Duisburg Essen, Essen, Germany. · Department of Cardiology, Kerckhoff-Klinik, Bad Nauheim, Germany. · Erasmus Medical Center, Rotterdam, The Netherlands. · St Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. · Columbia University Medical Center, Center for Interventional Vascular Therapy, New York Presbyterian Hospital, New York, USA. · Cardiovascular Department, King's College Hospital, London, UK. · Interventional Cardiology, McGill University Health Center, Montreal, Canada Cardiovascular Surgery, German Heart Center Munich, Bavaria, Germany. · Quebec Heart and Lung Institute, Québec, Canada. · Baylor Heart and Vascular Institute and the Departments of Internal Medicine (Division of Cardiology) and Pathology, Baylor University Medical Center, Dallas, TX, USA. · Department of Cardiology, Laval University, Quebec, Canada. · Bichat Hospital, University Paris VII, Paris, France. · Cardiac Imaging Department, University Hospital Ramon y Cajal, Madrid, Spain. · Department of Cardiology, Bern University Hospital, Bern, Switzerland. ·Eur Heart J · Pubmed #25062952.

ABSTRACT: An exponential increase in the use of transcatheter aortic valve implantation (TAVI) in patients with severe aortic stenosis has been witnessed over the recent years. The current article reviews different areas of uncertainty related to patient selection. The use and limitations of risk scores are addressed, followed by an extensive discussion on the value of three-dimensional imaging for prosthesis sizing and the assessment of complex valve anatomy such as degenerated bicuspid valves. The uncertainty about valvular stenosis severity in patients with a mismatch between the transvalvular gradient and the aortic valve area, and how integrated use of echocardiography and computed tomographic imaging may help, is also addressed. Finally, patients referred for TAVI may have concomitant mitral regurgitation and/or coronary artery disease and the management of these patients is discussed.

24 Review The diagnostic accuracy and outcomes after coronary computed tomography angiography vs. conventional functional testing in patients with stable angina pectoris: a systematic review and meta-analysis. 2014

Nielsen, Lene H / Ortner, Nino / Nørgaard, Bjarne L / Achenbach, Stephan / Leipsic, Jonathon / Abdulla, Jawdat. ·Department of Cardiology, Lillebaelt Hospital, Kabbeltoft 25, Vejle 7100, Denmark lenehuche@gmail.com. · Division of Cardiology, Department of Medicine, Glostrup University Hospital, Glostrup, Denmark. · Department of Cardiology B, Aarhus University Hospital Skejby, Aarhus N, Denmark. · Department of Cardiology, University of Erlangen, Erlangen, Germany. · Department of Medical Imaging, St. Paul's Hospital, Vancouver, BC, Canada. ·Eur Heart J Cardiovasc Imaging · Pubmed #24618659.

ABSTRACT: AIMS: To systematically review and perform a meta-analysis of the diagnostic accuracy and post-test outcomes of conventional exercise electrocardiography (XECG) and single-photon emission computed tomography (SPECT) compared with coronary computed tomography angiography (coronary CTA) in patients suspected of stable coronary artery disease (CAD). METHODS AND RESULTS: We systematically searched for studies published from January 2002 to February 2013 examining the diagnostic accuracy (defined as at least ≥50% luminal obstruction on invasive coronary angiography) and outcomes of coronary CTA (≥16 slice) in comparison with XECG and SPECT. The search revealed 11 eligible studies (N = 1575) comparing the diagnostic accuracy and 7 studies (N = 216.603) the outcomes of coronary CTA vs. XECG or/and SPECT. The per-patient sensitivity [95% confidence interval (95% CI)] to identify significant CAD was 98% (93-99%) for coronary CTA vs. 67% (54-78%) (P < 0.001) for XECG and 99% (96-100%) vs. 73% (59-83%) (P = 0.001) for SPECT. The specificity (95% CI) of coronary CTA was 82% (63-93%) vs. 46% (30-64%) (P < 0.001) for XECG and 71% (60-80%) vs. 48% (31-64%) (P = 0.14) for SPECT. The odds ratio (OR) of downstream test utilization (DTU) for coronary CTA vs. XECG/SPECT was 1.38 (1.33-1.43, P < 0.001), for revascularization 2.63 (2.50-2.77, P < 0.001), for non-fatal myocardial infarction 0.53 (0.39-0.72, P < 0.001), and for all-cause mortality 1.01 (0.87-1.18, P = 0.87). CONCLUSION: The up-front diagnostic performance of coronary CTA is higher than of XECG and SPECT. When compared with XECG/SPECT testing, coronary CTA testing is associated with increased DTU and coronary revascularization.

25 Review Coronary computed tomography angiography for stable angina: past, present, and future. 2013

Ajlan, Amr M / Heilbron, Brett G / Leipsic, Jonathon. ·Radiology Department, King Abdulaziz University Hospital, Jeddah, Saudi Arabia. ·Can J Cardiol · Pubmed #23148998.

ABSTRACT: Although the clinical use of computed tomography in cardiac imaging had slow beginnings, it has seen rapid development over the past decade. This review aims to discuss the state of the technology and to help clarify its role in the diagnosis and management of coronary artery disease. This article highlights major historic perspectives, the accuracy of coronary computed tomography angiography in evaluating obstructive coronary artery disease, associated radiation exposure issues, considerations in patient selection, and ongoing clinical and technologic advancements.

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