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Coronary Artery Disease: HELP
Articles by Jing-Ping Lin
Based on 2 articles published since 2008
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Between 2008 and 2019, Jing Lin wrote the following 2 articles about Coronary Artery Disease.
 
+ Citations + Abstracts
1 Review Serum bilirubin and genes controlling bilirubin concentrations as biomarkers for cardiovascular disease. 2010

Lin, Jing-Ping / Vitek, Libor / Schwertner, Harvey A. ·Office of Biostatistics Research, Division of Cardiovascular Science, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA. ·Clin Chem · Pubmed #20693308.

ABSTRACT: BACKGROUND: Serum bilirubin has been consistently shown to be inversely related to cardiovascular disease (CVD). Recent studies showed serum bilirubin to be associated with CVD-related factors such as diabetes, metabolic syndrome, and body mass index. Although the association of serum bilirubin with CVD has been found in both retrospective and prospective studies, less information is available on the role of genes that control bilirubin concentrations and their association with CVD. CONTENT: In this review, we provide detailed information on the identity of the major genes that control bilirubin concentrations and their association with serum bilirubin concentrations and CVD risk. We also update the results of the major studies that have been performed on the association between serum bilirubin, CVD, and CVD-related diseases such as diabetes or metabolic syndrome. Studies consistently indicate that bilirubin concentrations are inversely associated with different types of CVD and CVD-related diseases. A conditional linkage study indicates that UGT1A1 is the major gene controlling serum bilirubin concentrations, and this finding has been confirmed in recent genomewide association studies. Studies also indicate that individuals homozygous for UGT1A1*28 have a significantly lower risk of developing CVD than carriers of the wild-type alleles. SUMMARY: Serum bilirubin has a protective effect on CVD and CVD-related diseases, and UGT1A1 is the major gene controlling serum bilirubin concentrations. Pharmacologic, nonpharmacologic, or genetic interventions that increase serum bilirubin concentrations could provide more direct evidence on the role of bilirubin in CVD prevention.

2 Article ZIP8 induces monocyte adhesion to the aortas ex-vivo by regulating zinc influx. 2018

Cheng, Gong / Chang, Feng-Jun / You, Peng-Hua / Lin, Jing / Huang, Xiao-Yan / Wu, Hao-Yu / Yan, Li / Deng, Ji-Zhao / You, Hong-Jun / Sun, Chao-Feng. ·Department of Cardiology, The First Affiliated Hospital of Xi'an Jiaotong University, China. · Department of Cardiology, Shaanxi Provincial People's Hospital, China. · Department of Central Laboratory, Shaanxi Provincial People's Hospital, China. · Department of Cardiology, The First Affiliated Hospital of Xi'an Jiaotong University, China. Electronic address: chfsun1@126.com. ·Int Immunopharmacol · Pubmed #30015240.

ABSTRACT: Monocytes recruited and adhering to the inflamed arteries are crucial for atherosclerosis development. Here, we report the role of zinc (Zn