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Coronary Artery Disease: HELP
Articles by Martha H. Mackay
Based on 2 articles published since 2010
(Why 2 articles?)

Between 2010 and 2020, Martha Mackay wrote the following 2 articles about Coronary Artery Disease.
+ Citations + Abstracts
1 Article Outcomes following percutaneous coronary revascularization among South Asian and Chinese Canadians. 2017

Mackay, Martha H / Singh, Robinder / Boone, Robert H / Park, Julie E / Humphries, Karin H. ·School of Nursing, University of British Columbia, and St. Paul's Hospital, 1081 Burrard St, Vancouver, BC, V6Z 1Y6, Canada. mmackay@providencehealth.bc.ca. · Faculty of Medicine, University of Manitoba and St. Boniface Hospital, Winnipeg, Canada. · Division of Cardiology, University of British Columbia and St. Paul's Hospital, Vancouver, Canada. · BC Centre for Improved Cardiovascular Health, Vancouver, Canada. · Division of Cardiology, University of British Columbia, Vancouver, Canada. ·BMC Cardiovasc Disord · Pubmed #28420368.

ABSTRACT: BACKGROUND: Previous data suggest significant ethnic differences in outcomes following percutaneous coronary revascularization (PCI), though previous studies have focused on subgroups of PCI patients or used administrative data only. We sought to compare outcomes in a population-based cohort of men and women of South Asian (SA), Chinese and "Other" ethnicity. METHODS: Using a population-based registry, we identified 41,792 patients who underwent first revascularization via PCI in British Columbia, Canada, between 2001 and 2010. We defined three ethnic groups (SA, 3904 [9.3%]; Chinese, 1345 [3.2%]; and all "Others" 36,543 [87.4%]). Differences in mortality, repeat revascularization (RRV) and target vessel revascularization (TVR), at 30 days and from 31 days to 2 years were examined. RESULTS: Adjusted mortality from 31 days to 2 years was lower in Chinese patients than in "Others" (hazard ratio [HR] 0.72; 95% confidence interval [CI] 0.53-0.97), but not different between SAs and "Others". SA patients had higher RRV at 30 days (adjusted odds ratio [OR] 1.30; 95% CI: 1.12-1.51) and from 31 days to 2 years (adjusted hazard ratio [HR] 1.17; 95% CI: 1.06-1.30) compared to "Others". In contrast, Chinese patients had a lower rate of RRV from 31 days to 2 years (adjusted HR 0.79; 95% CI: 0.64-0.96) versus "Others". SA patients also had higher rates of TVR at 30 days (adjusted OR 1.35; 95% CI: 1.10-1.66) and from 31 days to 2 years (adjusted HR 1.19; 95% CI: 1.06-1.34) compared to "Others". Chinese patients had a lower rate of TVR from 31 days to 2 years (adjusted HR 0.76; 95% CI: 0.60-0.96). CONCLUSIONS: SA had higher RRV and TVR rates while Chinese Canadians had lower rates of long-term RRV, compared to those of "Other" ethnicity. Further research to elucidate the reasons for these differences could inform targeted strategies to improve outcomes.

2 Article Sex and Ethnic Differences in Outcomes of Acute Coronary Syndrome and Stable Angina Patients With Obstructive Coronary Artery Disease. 2016

Izadnegahdar, Mona / Mackay, Martha / Lee, May K / Sedlak, Tara L / Gao, Min / Bairey Merz, C Noel / Humphries, Karin H. ·From the Division of Cardiology (M.I., K.H.H.), School of Nursing (M.M.), and Vancouver General Hospital, Leslie Diamond Women's Heart Health Clinic (T.L.S.), University of British Columbia, Canada · Heart Centre (M.M.) and Providence Health Care Research Institute (M.M., M.K.L., K.H.H.), St. Paul's Hospital, British Columbia, Canada · BC Centre for Improved Cardiovascular Health, British Columbia, Canada (M.I., M.K.L., M.G., K.H.H.) · Centre for Health Evaluation and Outcomes Research, Canada (M.M., K.H.H.) · and Barbra Streisand Women's Heart Center, Cedars-Sinai Heart Institute, Los Angeles, CA (C.N.B.M.). ·Circ Cardiovasc Qual Outcomes · Pubmed #26908856.

ABSTRACT: BACKGROUND: The joint contribution of sex, ethnicity, and initial clinical presentation to the long-term outcomes of patients undergoing coronary angiography for acute coronary syndrome (ACS) or stable angina, in whom there is angiographic evidence for obstructive coronary artery disease, remains unknown. METHODS AND RESULTS: We conducted a population-based cohort study on 49 556 adult ACS or stable angina patients with angiographic evidence of obstructive coronary artery disease (≥ 50% stenosis) in British Columbia. The 2-year composite outcome was all-cause death and hospital readmissions for myocardial infarction, heart failure, cerebrovascular accident, or angina after the index angiography. Sex and ethnic differences in the composite outcome were examined by clinical presentation using the Cox proportional-hazards and logistic regression models. Overall, 25.6% were women, 9.5% were South Asians, 3.0% were Chinese, and 65.9% presented with ACS. Regardless of ethnicity, women were more likely than men to have adverse outcomes, but the magnitude of the sex difference was greater in the ACS patients (P(interaction) for sex and clinical presentation=0.03). Angina readmission accounted for 45% of the composite outcome and was the main component for all groups with the exception of Chinese women with ACS. Furthermore, women were more likely than men to be readmitted for angina (odds ratio [95% confidence interval], 1.13 [1.04-1.22]). CONCLUSIONS: Higher rates of adverse events among women with obstructive coronary artery disease, regardless of ethnicity, as well as high rates of angina readmission, highlight the need for more targeted interventions to reduce the burden of angina because this presentation is clearly not benign.