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Coronary Artery Disease: HELP
Articles by Michael Markl
Based on 2 articles published since 2008

Between 2008 and 2019, Michael Markl wrote the following 2 articles about Coronary Artery Disease.
+ Citations + Abstracts
1 Review Cardiovascular magnetic resonance phase contrast imaging. 2015

Nayak, Krishna S / Nielsen, Jon-Fredrik / Bernstein, Matt A / Markl, Michael / D Gatehouse, Peter / M Botnar, Rene / Saloner, David / Lorenz, Christine / Wen, Han / S Hu, Bob / Epstein, Frederick H / N Oshinski, John / Raman, Subha V. ·Ming Hsieh Department of Electrical Engineering, University of Southern California, 3740 McClintock Ave, EEB 406, Los Angeles, California, 90089-2564, USA. knayak@usc.edu. · Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. jfnielse@umich.edu. · Mayo Clinic, Rochester, MN, USA. mbernstein@mayo.edu. · Department of Radiology, Northwestern University, Chicago, IL, USA. mmarkl@northwestern.edu. · Cardiovascular Biomedical Research Unit, Royal Brompton Hospital, London, UK. p.gatehouse@rbht.nhs.uk. · Cardiovascular Imaging, Imaging Sciences Division, Kings's College London, London, UK. rene.botnar@kcl.ac.uk. · Department of Radiology and Biomedical Imaging, University of California San Francisco, San Francisco, CA, USA. david.saloner@ucsf.edu. · Center for Applied Medical Imaging, Siemens Corporation, Baltimore, MD, USA. christine.lorenz@siemens.com. · Imaging Physics Laboratory, National Heart Lung and Blood Institute, Bethesda, MD, USA. han.wen@nih.gov. · Palo Alto Medical Foundation, Palo Alto, CA, USA. hub@pamf.org. · Departments of Radiology and Biomedical Engineering, University of Virginia, Charlottesville, VA, USA. fredepstein@virginia.edu. · Departments of Radiology and Biomedical Engineering, Emory University School of Medicine, Atlanta, GA, USA. jnoshin@emory.edu. · Division of Cardiovascular Medicine, The Ohio State University, Columbus, OH, USA. raman.1@osu.edu. ·J Cardiovasc Magn Reson · Pubmed #26254979.

ABSTRACT: Cardiovascular magnetic resonance (CMR) phase contrast imaging has undergone a wide range of changes with the development and availability of improved calibration procedures, visualization tools, and analysis methods. This article provides a comprehensive review of the current state-of-the-art in CMR phase contrast imaging methodology, clinical applications including summaries of past clinical performance, and emerging research and clinical applications that utilize today's latest technology.

2 Article In vivo wall shear stress distribution in the carotid artery: effect of bifurcation geometry, internal carotid artery stenosis, and recanalization therapy. 2010

Markl, Michael / Wegent, Felix / Zech, Timo / Bauer, Simon / Strecker, Christoph / Schumacher, Martin / Weiller, Cornelius / Hennig, Jürgen / Harloff, Andreas. ·University Hospital Freiburg, Department of Radiology, Medical Physics, Germany. michael.markl@uniklinik-freiburg.de ·Circ Cardiovasc Imaging · Pubmed #20847189.

ABSTRACT: BACKGROUND: the purpose of this study was to analyze the in vivo distribution of absolute wall shear stress (WSS(abs)) and oscillatory shear index (OSI) in the carotid bifurcation and to evaluate its dependence on bifurcation geometry, the presence of internal carotid artery (ICA) stenosis, and recanalization therapy. METHODS AND RESULTS: time-resolved 3D blood flow was acquired with flow-sensitive 4D MRI in 64 normal carotid bifurcations and 17 carotid arteries with moderate ICA stenosis (48±6%) or after surgical recanalization. Among 64 normal arteries, atherogenic wall parameters were consistently concentrated in proximal bulb regions of the common (CCA) and internal (ICA) carotid arteries. The fraction of the carotid bulb exposed to atherosclerosis-prone wall parameters (low WSS(abs) below and high OSI above group-defined 20% and 10% thresholds) was correlated with the individual bifurcation geometry. Multiple regressions revealed significant (P<0.01) relationships (β, 0.44 to 0.48) between the areas with atherosclerosis-prone wall parameters and the d(ICA)/d(CCA) diameter ratio. The size of regions exposed to high OSI demonstrated highly significant (P≤0.01) relationships with all analyzed geometry parameters (d(ICA)/d(CCA) β, 0.48; tortuosity β, ≤-0.56; bifurcation angle β, ≥0.47). Moderate ICA stenosis altered the distribution of wall parameters (45%/61% reduction of individually low WSS(abs)/high OSI in the proximal ICA), which were relocated to segments distal to the arterial stenosis. WSS(abs)/OSI topology after recanalization was similar compared with the normal wall parameter distribution. CONCLUSIONS: flow-sensitive 4D MRI identified alterations in the segmental in vivo WSS distribution associated with atherosclerotic disease, surgical therapy, and individual bifurcation geometry and could be a valuable technique to assess the individual risk of flow-mediated atherosclerosis and carotid plaque progression.