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Coronary Artery Disease: HELP
Articles by Meriem Mrad
Based on 2 articles published since 2008
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Between 2008 and 2019, Meriem Mrad wrote the following 2 articles about Coronary Artery Disease.
 
+ Citations + Abstracts
1 Clinical Trial The Effect of ACE I/D Polymorphisms Alone and With Concomitant Risk Factors on Coronary Artery Disease. 2018

Amara, Ahmed / Mrad, Meriem / Sayeh, Aicha / Lahideb, Dhaker / Layouni, Samy / Haggui, Abdeddayem / Fekih-Mrissa, Najiba / Haouala, Habib / Nsiri, Brahim. ·1 Laboratoire de Biologie Moléculaire, Service d'Hématologie, Hôpital Militaire de Tunis, Montfleury, Tunisie. · 2 Faculté des Sciences de Tunis, Université Tunis el Manar, Tunis, Tunisie. · 3 Service de Cardiologie, Hôpital Militaire de Tunis, Montfleury, Tunisie. · 4 Faculté de Médecine de Tunis, Université de Tunis El Manar, Tunis, Tunisie. · 5 Faculté de Pharmacie, Université de Monastir, Monastir, Tunisie. · 6 Académie Militaire Fondouk Jédid, Nabeul, Tunisie. ·Clin Appl Thromb Hemost · Pubmed #27895197.

ABSTRACT: BACKGROUND: Coronary artery disease (CAD), also known as atherosclerotic heart disease, is a leading cause of mortality and morbidity throughout the world. The role of insertion/deletion (I/D) polymorphisms of the angiotensin-converting enzyme (ACE) gene in the etiology of CAD remains to be more completely clarified. The aim of this study was to determine the role of the ACE I/D polymorphism in patients with CAD and to study the association together with traditional risk factors in assessing the risk of CAD. METHODS: Our study population included 145 Tunisian patients with symptomatic CAD and a control group of 300 people matched for age and sex. All participants in the study were genotyped for the ACE I/D polymorphisms obtained by polymerase chain reaction amplification on genomic DNA. RESULTS: Our analysis showed that the ACE D allele frequency ( P < 10 CONCLUSION: The ACE D allele may be predictive in individuals who may be at risk of developing CAD. Further investigations of these polymorphisms and their possible synergisms with traditional risk factors for CAD could help to ascertain better predictability for CAD susceptibility.

2 Article Association of FV G1691A Polymorphism but not A4070G With Coronary Artery Disease. 2018

Amara, Ahmed / Mrad, Meriem / Sayeh, Aicha / Haggui, Abdeddayem / Lahideb, Dhaker / Fekih-Mrissa, Najiba / Haouala, Habib / Nsiri, Brahim. ·1 Hôpital Militaire de Tunis, Service d'Hématologie, Laboratoire de Biologie Moléculaire, Montfleury, Tunisie. · 2 Université Tunis el Manar, Faculté des Sciences de Tunis, Tunisie. · 3 Hôpital Militaire de Tunis, Service de Cardiologie, Montfleury, Tunisie. · 4 Université de Tunis El Manar, Faculté de Médecine de Tunis, Tunisie. · 5 Académie Militaire Fondouk Jédid, Nabeul, Tunisie. · 6 Université de Monastir, Faculté de Pharmacie, Monastir, Tunisie. ·Clin Appl Thromb Hemost · Pubmed #29179580.

ABSTRACT: Coronary artery disease (CAD) is one of the chief causes of death in the world. Several hypotheses have been promoted as for the origin of the disease, among which are genetic predispositions and/or environmental factors. The aim of this study was to determine the effect of factor V (FV) gene polymorphisms (Leiden, G1691A [FVL] and HR2 A4070G) and to analyze their association with traditional risk factors in assessing the risk of CAD. Our study population included 200 Tunisian patients with symptomatic CAD and a control group of 300 participants matched for age and sex. All participants were genotyped for the FVL and HR2 polymorphisms. Multivariate logistic regression was applied to analyze independent factors associated with the risk of CAD. Our analysis showed that the FVL A allele frequency ( P < 10