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Coronary Artery Disease: HELP
Articles by Witold Ruzyllo
Based on 5 articles published since 2010
(Why 5 articles?)

Between 2010 and 2020, Witold Ruzyłło wrote the following 5 articles about Coronary Artery Disease.
+ Citations + Abstracts
1 Clinical Trial Baseline Characteristics and Risk Profiles of Participants in the ISCHEMIA Randomized Clinical Trial. 2019

Hochman, Judith S / Reynolds, Harmony R / Bangalore, Sripal / O'Brien, Sean M / Alexander, Karen P / Senior, Roxy / Boden, William E / Stone, Gregg W / Goodman, Shaun G / Lopes, Renato D / Lopez-Sendon, Jose / White, Harvey D / Maggioni, Aldo P / Shaw, Leslee J / Min, James K / Picard, Michael H / Berman, Daniel S / Chaitman, Bernard R / Mark, Daniel B / Spertus, John A / Cyr, Derek D / Bhargava, Balram / Ruzyllo, Witold / Wander, Gurpreet S / Chernyavskiy, Alexander M / Rosenberg, Yves D / Maron, David J / Anonymous1211070. ·Cardiovascular Clinical Research Center, New York University School of Medicine, New York, New York. · Duke Clinical Research Institute, Duke University Medical Center, Durham, North Carolina. · Royal Brompton Hospital, London, United Kingdom. · Northwick Park Hospital, London, United Kingdom. · VA New England Healthcare System Boston, Boston, Massachusetts. · Columbia University Medical Center, New York, New York. · Cardiovascular Research Foundation, New York, New York. · St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. · Canadian Heart Research Centre, Toronto, Ontario, Canada. · Hospital Universitario La Paz, Instituto de Investigación Hospital Universitario La Paz, Madrid, Spain. · Green Lane Cardiovascular Services, Auckland Hospital, Auckland, New Zealand. · Associazione Nazionale Medici Cardiologi Ospedalieri Research Center, Florence, Italy. · Weill Cornell Medicine, New York, New York. · New York-Presbyterian Hospital, New York, New York. · Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. · Cedars-Sinai Medical Center, Los Angeles, California. · St Louis University School of Medicine, St Louis, Missouri. · Duke University Medical Center, Durham, North Carolina. · University of Missouri-Kansas City School of Medicine, Kansas City, Missouri. · All India Institutes of Medical Sciences, New Delhi, Delhi, India. · The Cardinal Stefan Wyszyński Institute of Cardiology, Warsaw, Poland. · Dayanand Medical College and Hospital, Ludhiana, Punjab, India. · E. Meshalkin National Medical Research Center, Ministry of Health of the Russian Federation, Novosibirsk, Russia. · National Heart, Lung, and Blood Institute, Bethesda, Maryland. · Stanford University School of Medicine, Stanford, California. ·JAMA Cardiol · Pubmed #30810700.

ABSTRACT: Importance: It is unknown whether coronary revascularization, when added to optimal medical therapy, improves prognosis in patients with stable ischemic heart disease (SIHD) at increased risk of cardiovascular events owing to moderate or severe ischemia. Objective: To describe baseline characteristics of participants enrolled and randomized in the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial and to evaluate whether qualification by stress imaging or nonimaging exercise tolerance test (ETT) influenced risk profiles. Design, Setting, and Participants: The ISCHEMIA trial recruited patients with SIHD with moderate or severe ischemia on stress testing. Blinded coronary computed tomography angiography was performed in most participants and reviewed by a core laboratory to exclude left main stenosis of at least 50% or no obstructive coronary artery disease (CAD) (<50% for imaging stress test and <70% for ETT). The study included 341 enrolling sites (320 randomizing) in 38 countries and patients with SIHD and moderate or severe ischemia on stress testing. Data presented were extracted on December 17, 2018. Main Outcomes and Measures: Enrolled, excluded, and randomized participants' baseline characteristics. No clinical outcomes are reported. Results: A total of 8518 patients were enrolled, and 5179 were randomized. Common reasons for exclusion were core laboratory determination of insufficient ischemia, unprotected left main stenosis of at least 50%, or no stenosis that met study obstructive CAD criteria on study coronary computed tomography angiography. Randomized participants had a median age of 64 years, with 1168 women (22.6%), 1726 nonwhite participants (33.7%), 748 Hispanic participants (15.5%), 2122 with diabetes (41.0%), and 4643 with a history of angina (89.7%). Among the 3909 participants randomized after stress imaging, core laboratory assessment of ischemia severity (in 3901 participants) was severe in 1748 (44.8%), moderate in 1600 (41.0%), mild in 317 (8.1%) and none or uninterpretable in 236 (6.0%), Among the 1270 participants who were randomized after nonimaging ETT, core laboratory determination of ischemia severity (in 1266 participants) was severe (an eligibility criterion) in 1051 (83.0%), moderate in 101 (8.0%), mild in 34 (2.7%) and none or uninterpretable in 80 (6.3%). Among the 3912 of 5179 randomized participants who underwent coronary computed tomography angiography, 79.0% had multivessel CAD (n = 2679 of 3390) and 86.8% had left anterior descending (LAD) stenosis (n = 3190 of 3677) (proximal in 46.8% [n = 1749 of 3739]). Participants undergoing ETT had greater frequency of 3-vessel CAD, LAD, and proximal LAD stenosis than participants undergoing stress imaging. Conclusions and Relevance: The ISCHEMIA trial randomized an SIHD population with moderate or severe ischemia on stress testing, of whom most had multivessel CAD. Trial Registration: ClinicalTrials.gov Identifier: NCT01471522.

2 Article The prevalence and characteristics of intra-atrial right coronary artery anomaly in 9,284 patients referred for coronary computed tomography angiography. 2014

Opolski, Maksymilian P / Pregowski, Jerzy / Kruk, Mariusz / Staruch, Adam D / Witkowski, Adam / Demkow, Marcin / Hryniewiecki, Tomasz / Michalek, Piotr / Ruzyllo, Witold / Kepka, Cezary. ·Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland. Electronic address: opolski.mp@gmail.com. · Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland. Electronic address: jerzypregowski74@gmail.com. · Department of Coronary and Structural Heart Diseases, Institute of Cardiology, Warsaw, Poland. Electronic address: mariuszkruk2000@yahoo.com. · Medical University of Warsaw, Warsaw, Poland. Electronic address: adstarman@gmail.com. · Department of Interventional Cardiology and Angiology, Institute of Cardiology, Warsaw, Poland. Electronic address: witkowski@hbz.pl. · Department of Coronary and Structural Heart Diseases, Institute of Cardiology, Warsaw, Poland. Electronic address: mdemkow@ikard.pl. · Department of Acquired Cardiac Defects, Institute of Cardiology, Warsaw, Poland. Electronic address: t.hryniewiecki@ikard.pl. · Department of Immediate Diagnostics, Institute of Cardiology, Warsaw, Poland. Electronic address: p.michalek@ikard.pl. · Department of Coronary and Structural Heart Diseases, Institute of Cardiology, Warsaw, Poland. Electronic address: w.ruzyllo@ikard.pl. · Department of Coronary and Structural Heart Diseases, Institute of Cardiology, Warsaw, Poland. Electronic address: c.kepka@ikard.pl. ·Eur J Radiol · Pubmed #24840476.

ABSTRACT: OBJECTIVE: To determine the prevalence, radiologic patterns and clinical characteristics of intra-atrial right coronary artery (IARCA) among adult coronary computed tomography angiography (CCTA) population. METHODS: We included 9,284 consecutive subjects who underwent CCTA at a single high-volume center. The presence of IARCA including the number, length and diameter of IARCA segments with accompanying atherosclerosis and coronary anomalies were evaluated. Additionally, clinical characteristics and midterm follow-up of IARCA patients were recorded. RESULTS: The IARCA prevalence was 0.15% (14/9,284) with 15 intra-atrial segments. The intra-atrial segment length ranged from 14 to 53 mm, and the mean diameter proximal to the entry site was 3.3 ± 0.7 mm. IARCA was more often associated with intramuscular course of the left anterior descending coronary artery (29% vs. 4%, p=0.001) and anomalous origin of the left circumflex artery from the right aortic sinus (14% vs. 0.3%, p=0.001) compared with non-IARCA cases. The majority of IARCA patients were women (86%) presenting with supraventricular arrhythmia (71%). Compared with computed tomographic population without IARCA, IARCA subjects were younger (60 ± 12 vs. 54 ± 14 years, p=0.037) and more often women (51% vs. 86%, p=0.013). At a mean of 20 months follow-up of IARCA patients there were no adverse cardiac events except for supraventricular tachycardia episodes occurring in 36% of subjects. CONCLUSIONS: IARCA occurs rarely and is often associated with additional coronary anomalies. The clinical profile of IARCA patients is most often represented by middle-aged women with supraventricular arrhythmia showing favorable midterm prognosis.

3 Article Five-year outcomes in patients with left main disease treated with either percutaneous coronary intervention or coronary artery bypass grafting in the synergy between percutaneous coronary intervention with taxus and cardiac surgery trial. 2014

Morice, Marie-Claude / Serruys, Patrick W / Kappetein, A Pieter / Feldman, Ted E / Ståhle, Elisabeth / Colombo, Antonio / Mack, Michael J / Holmes, David R / Choi, James W / Ruzyllo, Witold / Religa, Grzegorz / Huang, Jian / Roy, Kristine / Dawkins, Keith D / Mohr, Friedrich. ·From the Institut Cardiovasculaire Paris Sud, Hopital Privé Jacques Cartier, Générale de santé, Massy, France (M.-C.M.) · Erasmus University Medical Center Rotterdam, Rotterdam, The Netherlands (P.W.S., A.P.K.) · Evanston Hospital, Evanston, IL (T.E.F.) · University Hospital Uppsala, Uppsala, Sweden (E.S.) · San Raffaele Scientific Institute, Milan, Italy (A.C.) · Medical City Hospital, Dallas, TX (M.J.M.) · Mayo Clinic, Rochester, MN (D.R.H.) · Baylor Heart and Vascular Hospital, Dallas, TX (J.W.C.) · Institute of Cardiology, Warsaw, Poland (W.R., G.R.) · Boston Scientific Corporation, Natick, MA (J.H., K.R., K.D.D.) · University of Leipzig Heart Center, Leipzig, Germany (F.M.). ·Circulation · Pubmed #24700706.

ABSTRACT: BACKGROUND: Current guidelines recommend coronary artery bypass graft surgery (CABG) when treating significant de novo left main coronary artery (LM) stenosis; however, percutaneous coronary intervention (PCI) has a class IIa indication for unprotected LM disease in selected patients. This analysis compares 5-year clinical outcomes in PCI- and CABG-treated LM patients in the Synergy Between PCI With Taxus and Cardiac Surgery (SYNTAX) trial, the largest trial in this group to date. METHODS AND RESULTS: The SYNTAX trial randomly assigned 1800 patients with LM or 3-vessel disease to receive either PCI (with TAXUS Express paclitaxel-eluting stents) or CABG. The unprotected LM cohort (N=705) was predefined and powered. Major adverse cardiac and cerebrovascular event rates at 5 years was 36.9% in PCI patients and 31.0% in CABG patients (hazard ratio, 1.23 [95% confidence interval, 0.95-1.59]; P=0.12). Mortality rate was 12.8% and 14.6% in PCI and CABG patients, respectively (hazard ratio, 0.88 [95% confidence interval, 0.58-1.32]; P=0.53). Stroke was significantly increased in the CABG group (PCI 1.5% versus CABG 4.3%; hazard ratio, 0.33 [95% confidence interval, 0.12-0.92]; P=0.03) and repeat revascularization in the PCI arm (26.7% versus 15.5%; hazard ratio, 1.82 [95% confidence interval, 1.28-2.57]; P<0.01). Major adverse cardiac and cerebrovascular events were similar between arms in patients with low/intermediate SYNTAX scores but significantly increased in PCI patients with high scores (≥33). CONCLUSIONS: At 5 years, no difference in overall major adverse cardiac and cerebrovascular events was found between treatment groups. PCI-treated patients had a lower stroke but a higher revascularization rate versus CABG. These results suggest that both treatments are valid options for LM patients. The extent of disease should accounted for when choosing between surgery and PCI, because patients with high SYNTAX scores seem to benefit more from surgery compared with those in the lower tertiles. CLINICAL TRIAL REGISTRATION URL: http://www.clinicaltrials.gov. Unique identifier: NCT00114972.

4 Article Epicardial adipose tissue radiodensity is independently related to coronary atherosclerosis. A multidetector computed tomography study. 2011

Pracon, Radoslaw / Kruk, Mariusz / Kepka, Cezary / Pregowski, Jerzy / Opolski, Maksymilian P / Dzielinska, Zofia / Michalowska, Ilona / Chmielak, Zbigniew / Demkow, Marcin / Ruzyłło, Witold. ·Department of Coronary Artery Disease and Structural Heart Diseases, Institute of Cardiology, Warsaw, Poland. radekpracon@yahoo.pl ·Circ J · Pubmed #21178296.

ABSTRACT: BACKGROUND: Preliminary research indicates that epicardial adipose tissue (EAT) may display both anti- and proatherosclerotic properties. Because the varying radiodensities of selected human tissues assessed by multidetector computed tomography (MDCT) has been shown to reflect differences in biological characteristics, the present study investigated the hypothesis that the proatherosclerotic properties of EAT may be linked to its radiodensity. METHODS AND RESULTS: The study included 164 consecutive patients (82 females, mean age 58.8±11.1 years) with suspected coronary artery disease (CAD) undergoing MDCT coronary angiography. Coronary atherosclerosis was defined as: (1) CAD (ie, presence of at least 1 coronary stenosis ≥50%) and (2) coronary artery calcium (CAC) determined by Agatston score. EAT radiodensity was assessed by MDCT and averaged 81.00±4.64 HU (Hounsfield unit (HU) scale). Mean CAC score was 96.0±220.0. Patients with CAD (n=36) showed higher EAT radiodensity than patients without CAD (78.99±4.12 vs. -81.57±4.64 HU, P<0.01). In the multivariable model, only EAT radiodensity and age were independently associated with CAD (odds ratio (OR) 1.15, 95%confidence interval (CI) 1.04-1.28; OR 1.08, 95%CI 1.04-1.12; respectively). EAT radiodensity also correlated with CAC score (r=0.23, P<0.01). EAT radiodensity (P<0.001), age (P<0.001), sex (P=0.03), and past smoking (P<0.01) were independent correlates of CAC in the multivariable linear regression model. CONCLUSIONS: Increased EAT radiodensity is independently associated with coronary atherosclerosis, which may reflect the unfavorable, proatherosclerotic metabolic properties of more radiodense epicardial fat.

5 Article Reduced kidney function estimated by cystatin C and clinical outcomes in hypertensive patients with coronary artery disease: association with homocysteine and other cardiovascular risk factors. 2010

Dzielinska, Zofia / Januszewicz, Andrzej / Wiecek, Andrzej / Prejbisz, Aleksander / Zielinski, Tomasz / Chudek, Jerzy / Makowiecka-Ciesla, Magdalena / Demkow, Marcin / Tyczynski, Pawel / Januszewicz, Magdalena / Ruzyllo, Witold / Naruszewicz, Marek. ·1st Department of Coronary Artery Disease, Institute of Cardiology, Medical University of Warsaw, Warsaw, Poland. ·Kidney Blood Press Res · Pubmed #20516698.

ABSTRACT: AIMS: To evaluate the association between serum cystatin C and homocysteine concentrations, cardiovascular risk factors and cardiovascular events in hypertensive patients with coronary artery disease (CAD). METHODS: 260 patients with hypertension and CAD (mean age 56.9 +/- 9.3) were included. During a mean 40-month follow-up the combined end-point of death from all causes, non-fatal myocardial infarction and stroke or coronary revascularization was assessed. RESULTS: Subjects in the highest serum cystatin C quartile (>103.4 nmol/l) as compared with the lowest were older, were characterized by a higher frequency of multivessel CAD, higher levels of homocysteine (13.2 +/- 5.2 vs. 11.4 +/- 4.2 micromol/l; p < 0.01), fibrinogen and high-sensitivity C-reactive protein and by an increased intima-media thickness. Combined end-point occurred twice as frequently in the 4th quartile of serum cystatin C as compared with the 1st quartile (10.8 vs. 20.3%; p = 0.11). In an univariate analysis, but not in a multivariate model, cystatin C concentration predicted the combined end-point (Exp(B) = 1.096; p < 0.05). CONCLUSION: In hypertensive patients with CAD, serum cystatin C level was independently associated with the extent of CAD, homocysteine plasma level and traditional vascular risk factors. However, serum cystatin C concentration did not independently predict the combined end-point.