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Coronary Artery Disease: HELP
Articles by Masoumeh Sadeghi
Based on 22 articles published since 2010
(Why 22 articles?)
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Between 2010 and 2020, Masoumeh Sadeghi wrote the following 22 articles about Coronary Artery Disease.
 
+ Citations + Abstracts
1 Clinical Trial The Impacts of Cardiac Rehabilitation Program on Exercise Capacity, Quality of Life, and Functional Status of Coronary Artery Disease Patients with Left Ventricular Dysfunction. 2015

Sadeghi, Masoumeh / Garakyaraghi, Mohammad / Taghavi, Mahboobeh / Khosravi, Mohsen / Sarrafzadegan, Nizal / Roohafza, Hamidreza. ·Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Psychosomatic Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·Rehabil Nurs · Pubmed #24842623.

ABSTRACT: PURPOSE: To determine the impacts of cardiac rehabilitation on exercise capacity, quality of life (QOL), and functional status in patients with coronary artery disease (CAD). DESIGN: Self-controlled clinical trial. METHODS: CAD patients with mild to moderate left ventricular dysfunction participated in an exercise-based rehabilitation program for eight consecutive weeks. Subjects underwent an exercise test before and 8 weeks after rehabilitation. QOL was assessed with the SF-36 questionnaire. Functional status was assessed in terms of sleep time, walking, cycling, exercise, and working duration. FINDINGS: Seventy patients (age=57.5±10.2 years, 77.1% male) were studied. After rehabilitation, peak exercise capacity increased from 8.00±2.56 to 10.08±3.00 METs (p<.001) and exercise duration increased from 14.17±5.27 to 17.21±5.85 minutes (p<.001). Patients' QOL improved in physical and psychological dimensions (p<.05). Cycling, walking, and exercising status significantly increased after the study (p<.05). CONCLUSIONS: Cardiac rehabilitation improves exercise capacity, QOL, and functional status of CAD patients with mild to moderate left ventricular dysfunction. CLINICAL RELEVANCE: Cardiac rehabilitation practitioners should encourage patients to attend to and be compliant in the rehabilitation programs.

2 Article Effects of selenium supplementation on expression of SEPP1 in mRNA and protein levels in subjects with and without metabolic syndrome suffering from coronary artery disease: Selenegene study a double-blind randomized controlled trial. 2018

Gharipour, Mojgan / Ouguerram, Khadija / Nazih, El-Hassane / Salehi, Mansour / Behmanesh, Mehrdad / Roohafza, Hamidreza / Hosseini, Syed Mohsen / Nezafati, Pouya / Dianatkhah, Minoo / Gharipour, Amin / Haghjoo, Shaghayegh / Sarrafzadegan, Nizal / Sadeghi, Masoumeh. ·Division of Genetic Studies, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medicine Sciences, Isfahan, Iran. · UMR PHAN, INRA, and Université de Nantes, IMAD, CRNH-Ouest, Nantes, France. · Faculté de Pharmacie, EA 2160 MMS - Institut Universitaire Mer et Littoral FR3473 CNRS, Centre de Recherche en Nutrition Humaine Ouest (CRNH Ouest), ULB Université de Nantes, Nantes, France. · Department of Genetics and Molecular Biology Medical School, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Genetics, Faculty of Biological Sciences, Tarbiat Modares University, Tehran, Iran. · Psychosomatic Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Biostatistics and Epidemiology, School of Public Health, Isfahan University of Medical Sciences, Isfahan, Iran. · Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medicine Sciences, Isfahan, Iran. · Griffith University, School of Information and Communication Technology, Gold Coast Campus, Australia. · Applied Physiology Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·J Cell Biochem · Pubmed #29932230.

ABSTRACT: Selenoprotein P (SePP) is involved in the protection against diseases. The present study is the first investigation of the effect of selenium supplementation on plasma selenium and expression of SEPP1 in mRNA and protein levels based on metabolic syndrome (MetS), in individuals suffering from coronary artery diseases. In this clinical trial, 160 patients with angiographically documented stenosis of more than 75% in each vessel were enrolled. Patients received either 200-mg selenium yeast tablets or placebo tablets orally after a meal, once daily for 60 days. The mRNA and protein levels of the selenium and SePP1 products were determined before and after the study. From the initial 160 participants, 145 subjects (71 MetS-affected individuals, 74 MetS-unaffected individuals) enrolled in this study. Comparing the selenium and placebo groups, no significant percentage changes of plasma selenium, △Ct SEPP1, or SePP were shown (P > 0.05). Moreover, beyond a significant difference for the expression of SePP in the selenium group compared to its baseline level (P < 0.05), no other significant differences were revealed for plasma selenium and △Ct SEPP1 after the intervention in either group (P > 0.05). Selenium supplementation did not affect plasma selenium or the mRNA or protein level of SePP in either groups after a 2-months intervention beyond a significant increase of SePP in the MetS group. This trial suggests that further studies should investigate the long-term use of selenium supplementation and the effect of a SePP increase on MetS as a potential therapeutic effect.

3 Article A randomized trial of an optimism training intervention in patients with heart disease. 2018

Mohammadi, Narges / Aghayousefi, Alireza / Nikrahan, Gholam Reza / Adams, Caitlin N / Alipour, Ahmad / Sadeghi, Masoumeh / Roohafza, Hamidreza / Celano, Christopher M / Huffman, Jeff C. ·Department of Psychology, Payame Noor University, Tehran, Iran. · Department of Psychology, University of Isfahan, Isfahan, Iran. · Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. · Department of Cardiology, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Psychiatry, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Psychiatry, Massachusetts General Hospital, Boston, MA, USA; Department of Psychiatry, Harvard Medical School, Boston, MA, USA. Electronic address: jhuffman@mgh.harvard.edu. ·Gen Hosp Psychiatry · Pubmed #29316450.

ABSTRACT: OBJECTIVE: Optimism is prospectively and independently associated with superior cardiac outcomes, but there has been minimal study of optimism-specific interventions in persons with cardiovascular illness. We aimed to examine the feasibility and impact of an optimism-promoting program among patients with heart disease in a randomized controlled trial. METHODS: Participants (N=61) were outpatients, age 35-60, with coronary artery disease who were randomized to an 8-week in-person group-based optimism training intervention or an attention-matched educational control condition. Feasibility was assessed via rates of session attendance and exercise completion, and acceptability was assessed via weekly participant ratings of exercise ease, utility, and likelihood of continuation. The impact of the intervention was assessed via between-group differences in change from baseline optimism (Life Orientation Test-Revised [LOT-R]) and other psychological self-report outcomes at 8weeks (primary time point) and 16weeks, using random effects regression models. RESULTS: Participants completed a mean of 6.8 (SD 1.2) sessions and 13.9 (SD 2.4) exercises, with mean ratings all >3.5/5 on measures of acceptability. The intervention was associated with greater improvement in optimism at 8weeks (β=5.13; 95% confidence interval [CI]=3.55, 6.70; p<0.001) and 16weeks; the intervention was also associated with greater improvements in life satisfaction, hope, and anxiety at both time points, though not with positive or negative affect. CONCLUSIONS: A group-based optimism training program was feasible, acceptable, and associated with improvements in optimism and other psychological measures in cardiac patients. Future larger studies should examine effects on major clinical outcomes.

4 Article The Effect of Resistance Exercise on Lipid Profile of Coronary Artery Disease Patients: A Randomized Clinical Trial. 2017

Salehi, Zahra / Salehi, Kobra / Moeini, Mahin / Kargarfard, Mehdi / Sadeghi, Masoumeh. ·Adult Health Nursing, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran. · Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Adult Health Nursing, Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Isfahan, Isfahan, Iran. · Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·Iran J Nurs Midwifery Res · Pubmed #28584548.

ABSTRACT: BACKGROUND: Increased level of blood lipids is one of the risk factors for cardiovascular diseases. Considerable research has done to assess the effects of physical exercises on lipid profile, of which aerobic exercises are the main part of evidence. However, in recent years, resistance exercise has been less investigated. Thus, the present study investigates the effect of resistance exercise on lipid profile in coronary artery disease patients. MATERIALS AND METHODS: This study was a randomized clinical trial. Forty eligible participants were selected through selective sampling and were assigned randomly to either intervention or control groups (20 participants in each group). Fasting blood sample was taken for measurement of lipid profile before, after, and after 4 weeks of the end of intervention. The intervention period lasted 8 weeks and included two exercise sessions of 45-60 minutes per week. Resistance exercise was performed by use of light weights in the range of motion of the elbow, shoulder, and knee joints. The number of repetitions was initially 10 and was gradually increased to 15. Then, the weight was increased by 3-5% and the number of sets too. Data were analyzed on significant level of RESULTS: In both the groups, the mean and mean changes of lipid profile, before, after. and 4 weeks after the end of the intervention were not significantly different ( CONCLUSIONS: The 8-week of resistance exercise did not lead to a significant decrease in the mean lipid profile.

5 Article Investigation of membrane fatty acid profiles in erythrocytes of patients with stable coronary artery disease. 2016

Namazi, Gholamreza / Asa, Parastoo / Movahedian, Ahmad / Sarrafzadegan, Nizal / Sadeghi, Masoumeh / Pourfarzam, Morteza. ·Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran. · Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences, Isfahan, Iran; Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. Electronic address: Pourfarzam@pharm.mui.ac.ir. ·J Clin Lipidol · Pubmed #27578125.

ABSTRACT: BACKGROUND: The association between the erythrocyte membrane fatty acids and the severity of coronary stenosis has not been studied in patients with stable coronary artery disease (CAD). OBJECTIVE: We sought to investigate whether the fatty acid profile of erythrocyte membranes is significantly different in patients with stable CAD compared with patients with nonsignificant coronary stenosis and evaluate a possible relationship between fatty acid profile and the severity of coronary stenosis. METHODS: The population included 144 patients, undergoing clinically indicated coronary angiography. The severity of coronary stenosis was scored after coronary angiography, and patients were divided into 2 groups; the S-stenosis group (CAD patients, n = 82) had a significant stenosis indicated by coronary angiography and the second group, S-stenosis (n = 62), had nonsignificant coronary stenosis. RESULTS: The erythrocyte membranes linoleic acid (LA) levels were lower (P < .001) and the arachidonic acid (AA)-to-LA ratio, a marker of desaturase activity, were higher (P < .001) in CAD patients compared with S-stenosis patients. The CAD scores were correlated negatively with the membrane LA levels (r = -0.338; P < .001) and positively with the AA-to-LA ratio (r = 0.306; P < .001). CONCLUSIONS: This study shows that LA levels of the erythrocyte membrane and AA-to-LA ratio are correlated with the severity of CAD.

6 Article Association between serum myeloperoxidase levels and coronary artery disease in patients without diabetes, hypertension, obesity, and hyperlipidemia. 2016

Hasanpour, Zahra / Javanmard, Shaghayegh Haghjooy / Gharaaty, Maryam / Sadeghi, Masoumeh. ·Department of Physiology, Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. · Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran. ·Adv Biomed Res · Pubmed #27376042.

ABSTRACT: BACKGROUND: Myeloperoxidase (MPO) is an enzyme, elevated in the atheroma and serum of a patient with atherosclerotic vessels. The aim of this study is to investigate whether the serum MPO level is related to the presence of plaque in patients without risk factors, such as, diabetes, hypertension, obesity, and hyperlipidemia. MATERIALS AND METHODS: A serum sample was collected from patients who referred for angiography. The MPO level was measured in the serum samples of 40 patients without risk factors for atherosclerosis using the enzyme-linked immunosorbent assay (ELISA). RESULTS: The MPO level was 245.5 ± 13.8 (ng/ml) in patients with atherosclerosis and 213.9 ± 8.9 (ng/ml) in patients without atherosclerosis. There was a significant difference between the groups (P = 0.002). The odds ratio was 0.67 (0.95 CI, 0.17 - 2.5) for patients with and without coronary atherosclerosis. CONCLUSION: Although the MPO concentration is higher in patients suffering from atherosclerosis, it is not a predictor of coronary artery disease in patients without diabetes, hypertension, obesity, and hyperlipidemia.

7 Article Obstructive sleep apnea, diagnosed by the Berlin questionnaire and association with coronary artery disease severity. 2015

Ghazal, Abdullatef / Roghani, Farshad / Sadeghi, Masoumeh / Amra, Babak / Kermani-Alghoraishi, Mohammad. ·Resident, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Associate Professor, Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Associate Professor, Cardiac Rehabilitation Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Associate Professor, Department of Pulmonology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. · Resident, Hypertension Research Center, Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·ARYA Atheroscler · Pubmed #26715932.

ABSTRACT: BACKGROUND: Obstructive sleep apnea syndrome (OSAS) is a highly prevalent sleep-related disorder that is associated with increased risk of hypertension (HTN) and coronary heart disease. This study aimed to evaluate the correlation between the OSAS and coronary artery disease (CAD) severity. METHODS: The cross-sectional study was conducted from September 2012 to December 2013. We enrolled 127 patients with chronic stable angina who were referred for coronary angiographic studies in Shahid Chamran and Nour Hospitals in Isfahan, Iran. The Berlin questionnaire (BQ) was used for estimate the probability of OSAS in patients as a low or high probability. Demographic characteristics and metabolic risk factors including diabetes mellitus, HTN, obesity, and smoking also were recorded. The severity of CAD was assessed and compared based on the Gensini score with Mann-Whitney U statistical test. Independent t-test for continuous variables and chi-square test for categorical variables were used. RESULTS: Totally, 65.4% of subjects were considered as high and 34.6% as low probability for OSAS, which 81.1% of them had CAD. There was a significant difference between body mass index, systolic blood pressure, diastolic blood pressure, and ischemic heart disease drug consumption with OSAS probability (P < 0.0500). CAD was accompanied by OSAS significantly (P = 0.0260). The Gensini score was significantly higher in patients with high OSAS probability (100.4 ± 69.1 vs. 65.3 ± 68.9; P = 0.0030). OSAS also increase odds of CAD based on regression analysis (odds ratio, 95% confidence interval = 2.7). CONCLUSION: This study indicates that more severe CAD is associated with high OSAS probability identified by BQ.

8 Article The effect of resistance exercise on mean blood pressure in the patients referring to cardiovascular research centre. 2015

Moeini, Mahin / Salehi, Zahra / Sadeghi, Masoumeh / Kargarfard, Mehdi / Salehi, Kobra. ·Department of Adult Health Nursing, Nursing and Midwifery Care Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Nursing, Student Research Center, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran. · Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Exercise Physiology, Faculty of Physical Education and Sport Sciences, University of Isfahan, Isfahan, Iran. · Student of Reproductive Health, Department of Midwifery, School of Nursing and Midwifery, Isfahan University of Medical Sciences, Isfahan, Iran. ·Iran J Nurs Midwifery Res · Pubmed #26257796.

ABSTRACT: BACKGROUND: One of the most important risk factors for cardiovascular disease is hypertension. 1 billion people in the world and 25-35% of the adult population in Iran suffer from hypertension. Despite the emphasis on medicational treatments, non-medicational treatments and modification of lifestyle, including physical activity and exercise, are important for the control and treatment of hypertension and lead to a reduction in cardiovascular diseases. Among the various types of exercises, resistance exercise has been considered important by the cardiologists. The present study investigates the effect of resistance exercise on mean blood pressure in the cardiovascular patients. MATERIALS AND METHODS: In a randomized clinical trial, 40 patients admitted to the rehabilitation unit of cardiovascular research center were assigned to study and control groups. Demographic data were collected. Their blood pressure values were measured and recorded once 1 day before the beginning of the intervention and another time 1 day after its completion. All study subjects participated in two 45-60 min exercise sessions for eight straight weeks. The control group followed routine rehabilitation unit protocol that was aerobic exercise. The study group subjects performed resistance exercise in addition to routine exercise. The weight was determined in the first session of the intervention. At the beginning, the number of the repetitions in the range of motion was 10, which was increased gradually to 15. After it reached 15 repetitions, the amount of weight was increased by 3-5% and the number of sets increased. RESULTS: One day before the beginning of the intervention, mean systolic blood pressure was 128.21 (15.39) mmHg in the study group and 120.00 (20.51) mmHg in the control group. Mean diastolic blood pressure was 82.50 (9.35) mmHg in the study group and 82.00 (13.11) mmHg in the control group. There were no differences between the groups in terms of mean systolic and diastolic blood pressure (P > 0.05). After the end of the intervention, mean systolic blood pressure values were 116.42 (7.18) mmHg and 112.00 (12.60) mmHg in the study and control groups, respectively. There were no significant differences between the groups (P = 0.24). Mean diastolic blood pressure values were 81.78 (7.99) mmHg in the study group and 78.25 (12.48) mmHg in the control group. There was no significant difference between the groups (P = 0.35). At the end of the intervention, mean systolic blood pressure in the study group decreased significantly (P = 0.02). CONCLUSIONS: In the present study, the effect of resistance exercise on mean systolic blood pressure showed a significant difference, caused by the aerobic exercise.

9 Article Effect of vitamin D therapy on endothelial function in ischemic heart disease female patients with vitamin D deficiency or insufficiency: A primary report. 2015

Hashemi, Sayed Mohammad / Mokhtari, Sayed Meisam / Sadeghi, Masoumeh / Foroozan, Rezvan / Safari, Mahboobeh. ·Associate Professor, Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Resident, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Associate Professor, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Cardiology, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran. ·ARYA Atheroscler · Pubmed #26089932.

ABSTRACT: BACKGROUND: Vitamin D deficiency is associated with vascular endothelial dysfunction. We evaluated endothelial function in ischemic heart disease (IHD) patients with vitamin D deficiency or insufficiency before and after vitamin D therapy. METHODS: An uncontrolled before-after study was conducted in Isfahan, Iran on consecutive sample of female IHD patients who had undergone percutaneous coronary intervention in the preceding 6 months and/or referred with chronic stable angina. Forty patients with vitamin D deficiency or insufficiency (serum 25-hydroxy vitamin D < 20 or 20-30 ng/ml, respectively) were included and received two intramuscular injections of 300,000 IU cholecalciferol with 1 month interval. Endothelial function, assessed by measuring flow-mediated dilatation (FMD), and serum 25-hydroxy vitamin D level were measured at baseline and 1 month after the second dose of cholecalciferol. RESULTS: A total of 30 patients completed the study, age = 59.4 ± 8.7 years; serum 25-hydroxy vitamin D = 19.0 ± 6.5 ng/ml. After treatment, serum 25-hydroxy vitamin D was reached to > 30 ng/ml in all patients. Brachial artery diameter (mm) after ischemia increased significantly, statistically but not clinically (4.55 ± 0.37 to 4.67 ± 0.38, P < 0.001). Furthermore, FMD (%) was increased from 1.96 ± 1.65 to 4.65 ± 1.27 (P < 0.001). The amount of change in FMD was not significantly correlated with serum 25-hydroxy vitamin D (r = 0.038, P = 0.858). CONCLUSION: Endothelial function was improved after vitamin D therapy in IHD patients with low serum vitamin D. Controlled studies with larger sample size are required to confirm if vitamin D therapy has effects on endothelial function.

10 Article Detrimental predictive effect of metabolic syndrome on postoperative complications in patients who undergoing coronary artery bypass grafting. 2015

Gharipour, Mojgan / Sadeghi, Mohsen Mirmohammad / Sadeghi, Masoumeh / Farhmand, Niloufar / Sadeghi, Pouya Mirmohammad. ·Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. mojgangharipour@gmail.com. ·Acta Biomed · Pubmed #25948033.

ABSTRACT: BACKGROUND: The present study came to address the value of metabolic syndrome (MetS) in predicting postoperative outcome following coronary artery bypass grafting (CABG). METHODS: In a retrospective study, a consecutive series of patients including 2010 subjects who underwent isolated CABG were reviewed. Baseline information and intraoperative details were collected by reviewing hospital-recorded files. The composite outcome of major adverse cardiac and cerebrovascular events (postoperative morbidity) was generated from the occurrence of myocardial infarction, cardiac arrhythmias, stroke, renal failure, and other cardiac-related problems. RESULTS: Overall, 2010 patients who underwent isolated CABG were studied that among them 24.7% suffered from MetS. No difference was found in the prevalence of postoperative arrhythmias, brain stroke, multi-organ failure, and dialysis between the two groups with and without MetS. Early morbidity rate was 27.4% in MetS group and 27.8% in non-MetS group with no significant discrepancy. Using multivariable logistic regression modeling, we showed that MetS status could not predict postoperative morbidity; however, advanced age, history of congestive heart failure, higher Canadian Cardiovascular Society (CCS) scale, and longer cross-clamp time were main indicators of postoperative morbidity.  CONCLUSION: MetS has no detrimental predictive effect on early postoperative morbidity in CABG patients. (www.actabiomedica.it).

11 Article Increased membrane lipid peroxidation and decreased Na+/K+-ATPase activity in erythrocytes of patients with stable coronary artery disease. 2015

Namazi, Gholamreza / Jamshidi Rad, Sabieh / Attar, Ahmad Movahedian / Sarrafzadegan, Nizal / Sadeghi, Masoumeh / Naderi, Gholamali / Pourfarzam, Morteza. ·aDepartment of Clinical Biochemistry, School of Pharmacy and Pharmaceutical Sciences bIsfahan Cardiovascular Research Center cCardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·Coron Artery Dis · Pubmed #25426658.

ABSTRACT: OBJECTIVES: We aimed to determine erythrocyte membrane lipid peroxidation levels and Na/K-ATPase activity in patients with and without coronary artery disease (CAD) documented by coronary angiography. DESIGN AND METHODS: A total of 144 patients who had undergone coronary angiography were divided into a CAD group (n=82) and a non-CAD group (control group, n=62) according to the results of coronary angiography. Lipid peroxide levels in plasma and the erythrocyte membrane were measured using a fluorimetric method. Total antioxidant status and Na/K-ATPase activity in plasma were determined using spectrophotometric methods. RESULTS: Lipid peroxidation levels were significantly higher in the erythrocyte membrane of CAD patients compared with controls, whereas Na/K-ATPase activity was significantly lower in the erythrocyte membrane of CAD patients compared with controls. The coronary artery scores were correlated positively with membrane lipid peroxidation (r=0.324, P<0.001) and negatively with Na/K-ATPase activity (r=-0.302, P<0.001). CONCLUSION: This study shows that the levels of membrane lipid peroxidation and Na/K-ATPase activity are correlated with the severity of CAD.

12 Article Psychological state in patients undergoing coronary artery bypass grafting surgery or percutaneous coronary intervention and their spouses. 2015

Roohafza, Hamidreza / Sadeghi, Masoumeh / Khani, Azam / Andalib, Elham / Alikhasi, Hasan / Rafiei, Mohammadali. ·Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·Int J Nurs Pract · Pubmed #24750214.

ABSTRACT: Percutaneous coronary intervention (PCI) and the coronary artery bypass grafting surgery (CABG) are well accepted treatments for coronary artery disease. Many patients and their spouses experience increased level of stress, anxiety and depression before and after going under the procedure. One hundred and ninety-six cardiac patients who were candidate for CABG or PCI procedures and their spouses were asked to complete Hospital Anxiety and Depression Scale and General Health Questionnaire-12 before and 1 month after procedures. Anxiety, depression and stress level in patients and their spouses going under the procedures significantly reduced over time. Scores of anxiety, depression and stress in patients and their spouses were correlated. There was no difference in the level of anxiety, depression and stress between CABG and PCI groups before to after procedures. We suggest providing information about the procedures to both patients and their spouses to deal better with their own psychological state.

13 Article Coronary bypass surgery versus percutaneous coronary intervention: cost-effectiveness in Iran: a study in patients with multivessel coronary artery disease. 2014

Javanbakht, Mehdi / Bakhsh, Razieh Yazdani / Mashayekhi, Atefeh / Ghaderi, Hossein / Sadeghi, Masoumeh. ·Health Economics Research Unit,Institute of Applied Health Sciences,University of Aberdeen;Health Management and Economics Research Center,School of Health Management and Information Sciences,Iran University of Medical Sciencesm.javanbakht@abdn.ac.uk. · Isfahan University of Medical Sciences. · Tehran University of Medical Sciences. · Health Economics Department,School of Health Management and Information Sciences,Iran University of Medical Sciences. · Cardiac Rehabilitation Research Center,Isfahan Cardiovascular Research Institute,Isfahan University of Medical Sciences. ·Int J Technol Assess Health Care · Pubmed #25401422.

ABSTRACT: OBJECTIVES: The aim of this study was to evaluate cost effectiveness of coronary artery bypass graft (CABG) versus percutaneous coronary intervention (PCI) with stenting from Iran society perspective. METHODS: A retrospective study was carried out to estimate the annual cost and health related quality of life (HRQoL) of 109 patients who underwent coronary revascularization (PCI [n = 75] and CABG [n = 34]). A Markov model has been developed to determine the cost effectiveness of CABG compared with PCI. We used the model to calculate lifetime costs, life-years (LYs), and quality-adjusted life-years (QALYs) of each strategy. We also used probabilistic sensitivity analysis to test model robustness. RESULTS: We found that discounted QALY lived per person in CABG versus PCI group in 5 years, 10 years, and lifetime time horizon were (3.8 ± 0.13 versus 3.88 ± 0.14), (6.4 ± 0.23 versus 6.33 ± 0.22), and (8.74 ± 0.29 versus 8.33 ± 0.27), respectively. The estimated medical cost of CABG and PCI per patient in 5 years, 10 years, and lifetime time horizon were (USD 6,819 ± 765 versus 9,011 ± 1,816), (USD 8,852 ± 1,348 versus 12,034 ± 2,375), and (USD 14,037± 4,201 versus 18,798 ± 5,821), respectively. The incremental cost-effectiveness ratio results showed CABG is a dominate alternative in 10 years and lifetime time horizon. CONCLUSIONS: This study demonstrated that despite higher initial cost and lower HRQoL, CABG is a cost-effective revascularization strategy compared with PCI for patients with multivessel coronary artery disease in long-term.

14 Article Myeloperoxidase levels predicts angiographic severity of coronary artery disease in patients with chronic stable angina. 2014

Baseri, Mehdi / Heidari, Ramin / Mahaki, Behzad / Hajizadeh, Yaghoub / Momenizadeh, Amir / Sadeghi, Masoumeh. ·Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Biostatistics, Isfahan University of Medical Sciences, Isfahan, Iran. · Environment Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. · Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·Adv Biomed Res · Pubmed #25161986.

ABSTRACT: BACKGROUND: Myeloperoxidase (MPO) has an important role in the both processes of inflammation and oxidative stress. It plays proatherogenic role via low-density lipoprotein oxidation, functional inactivation of the high-density lipoprotein and endothelial dysfunction, and seems to be involved in the atherogenesis of coronary arteries. This study designed to evaluate the association between the plasma MPO levels and angiographic severity of coronary artery disease (CAD) in patients with the stable CAD. MATERIALS AND METHODS: Sixty-eight patients who had documented CAD with angiography and 66 subjects who had normal angiography were selected as case and the control groups for this study, respectively. Gensini scoring system was used for evaluation of severity of coronary artery stenosis. Plasma MPO and C-reactiveprotein (CRP) levels of both case and control groups were determined. RESULTS: Plasma MPO levels and CRP levels were significantly higher in CAD patients (P < 0.001), and plasma levels of MPO and CRP were correlated with Genssini scores. CONCLUSIONS: Our findings indicated that the plasma MPO levels increase in patients with stable CAD and hence that, it can be used as adiagnostic factor to predict the coronary artery atherosclerosis severity in stable CAD patients; However, it needs further widespread investigations to achieve an accurate cut point.

15 Article Prognostic value of the high-mobility group box-1 in young patients with chest pain. 2014

Haghjooy-Javanmard, Shaghayegh / Sadeghi, Masoumeh / Safavi, Shiva / Gheraati, Maryam / Dana, Nasim. ·Associate Professor, Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. · Associate Professor, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. · Applied Physiology Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. ·ARYA Atheroscler · Pubmed #25161686.

ABSTRACT: BACKGROUND: Atherosclerosis is accepted as an inflammatory disease. Evidence suggests that inflammation evoked by injury plays a pathogenic role in all stages of atherosclerosis. This study aimed to investigate whether the high-mobility group box-1 (HMGB1) a proinflammatory cytokine/nuclear protein, which is derived from both injured endothelium and activated macrophages/monocytes, could contribute to the progression of atherosclerosis and other cardiovascular diseases. METHODS: This study was designed as case-control. A total of 135 patients who referred to the hospital due to angina pectoris had the diagnosis of unstable angina and were candidates of angiography were recruited in this study. Forty patients who had coronary artery disease confirmed by angiography were considered as case group and control group consists of 40 persons who had no plaque, and 55 persons were excluded according to the exclusion criteria. At first, a questionnaire was filled for each patient including demographic factors and their medical history. Then a blood sample was taken to assess the level of HMGB1. Data were analyzed using SPSS, Student's independent t-test, and chi-square tests. RESULTS: The mean plasma level of HMGB1 in the case group was 27.1 ± 2.9 ng/ml, while it was 19.6 ± 1.9 ng/ml in control groups (P = 0.03). The odds ratio for coronary artery plaque associated with high (> 15.03 ng/ml) levels of HMGB1 was 2.50 (95% confidence interval, 1.02-6.17, P = 0.03). CONCLUSION: Increased plasma HMGB1 concentration may be associated with an increased risk of coronary atherosclerosis.

16 Article Does significant weight reduction in men with coronary artery disease manage risk factors after cardiac rehabilitation program? 2013

Sadeghi, Masoumeh / Ghashghaei, Fatemeh Esteki / Rabiei, Katayoun / Golabchi, Allahyar / Noori, Fatemeh / Baboli, Mozhgan Teimourzadeh / Sarrafzadegan, Nizal. ·Department of Cardiology, Cardiac Rehabilitation Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Physical Education and Sport Sciences, Khorasgan Branch, Islamic Azad University, Isfahan, Iran. · Cardiovascular Research Center, Isfahan University of Medical Sciences, Isfahan, Iran. · Cardiac Electrophysiology Research Center, Rajaie Cardiovascular Medical and Research Center, Tehran University of Medical Sciences, Tehran, Iran. · Biostatics Unit, Isfahan University of Medical Sciences, Isfahan, Iran. · Department of Internal Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran. · Department of Cardiology, Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·J Res Med Sci · Pubmed #24523781.

ABSTRACT: BACKGROUND: Vast majority of cardiac patients who refer to cardiac rehabilitation program (CRP) are obese and obesity is associated with coronary heart disease (CHD). So, the aim of this study is to investigate the effects of CRP on obesity indexes, lipid profiles, and functional capacity (FC) in obese men with CHD and to explore whether significant weight reduction affected these risk factors and FC or not. MATERIALS AND METHODS: In an observational study, we evaluated 536 patients, including 464 non-obese men and 72 obese men. All participants completed CRP for 2 months; then, obese patients were divided into two groups: patients with weight reduction ≥ 5% and patients who didn't have significant weight reduction. Data were analyzed with SPSS software version 15. For comparing the mean of outcomes independent t-tests and paired t-tests were used. RESULTS: Results showed following CRP, non-obese men had significant improvement in obesity indexes (P = 0.00), lipid profiles (P < 0.05), and FC (P = 0.00) and in obese men, favorable improvement were seen in obesity indexes (P = 0.00), FC (P = 0.00), and total cholesterol (P = 0.02). Comparing two groups revealed that there were significant differences in obesity indexes, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio. In addition, comparing subgroup of obese patients revealed that there were significant differences in FC (P = 0.00) and low-density lipoprotein cholesterol/ high-density lipoprotein cholesterol ratio (P = 0.04). CONCLUSION: CRP has more advantage in management of obesity, FC, and lipid profiles in both obese and non-obese patients. Also, weight reduction may cause greater improvement in FC and fitness levels in obese men with CHD.

17 Article Association of vitamin D deficiency and coronary artery disease with cardiovascular risk factors. 2012

Siadat, Zahra Dana / Kiani, Keyvan / Sadeghi, Masoumeh / Shariat, Amir Sina / Farajzadegan, Ziba / Kheirmand, Maryam. ·Department of Community Medicine, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·J Res Med Sci · Pubmed #23833580.

ABSTRACT: BACKGROUND: Vitamin D deficiency is a prevalent condition in many countries. The aim of this study is to elucidate whether deficient vitamin D status is associated with coronary artery disease considering cardiovascular risk factors. MATERIALS AND METHODS: We measured 25 (OH) D serum levels in 57 patients that were diagnosed with coronary artery disease upon coronary angiography and 62 individuals in the control group who were matched for age and sex with the patients and examined the association between serum 25 (OH) D and coronary artery disease with regard to cardiovascular risk factors. RESULTS: The odds ratio of being affected by coronary artery disease in individuals with vitamin D deficiency (25 (OH) D < 30 ng/ml) was 5.8 (1.77 - 18.94) after adjustment with cardiovascular risk factors, i.e., blood pressure, diabetes, smoking, obesity, physical activity and high blood cholesterol in comparison with the control group. CONCLUSION: Low levels of 25 (OH) D are associated with prevalent coronary artery disease independent of cardiovascular risk factors. Further investigations could demonstrate the need for vitamin D supplementations in order to prevent atherosclerosis.

18 Article Is prehypertension a risk factors for cardiovascular diseases among Iranian women? 2012

Aghababaei, Ismail / Sadeghi, Masoumeh / Talaei, Mohammad / Rabiei, Katayoun / Sarrafzadegan, Nizal. ·Isfahan Cardiovascular Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·J Res Med Sci · Pubmed #23825995.

ABSTRACT: BACKGROUND: Numerous studies have reported prehypertension (pre-HTN) as a risk factor for the cardiovascular diseases as hypertension (HTN). AIM: The present study aimed to evaluate the effects of pre-HTN on cardiovascular incidences among the females of Isfahan cohort study (ICS). MATERIALS AND METHODS: Healthy female at baseline were followed for a median of 6.7 years. They were divided into 3 groups of normal blood pressure, pre-HTN (120/80 < BP < 139/89 mmHg) and HTN (BP > 140/90 mmHg) based on their baseline measurements. The endpoints were ischemic heart disease (IHD), stroke, CVD (combination of IHD and stroke) and mortality. RESULTS: Normal BP, pre-HTN and HTN were observed in 1073 (33%), 1185 (36%), and 994 (31%) participants, respectively. One hundred and ninety-eight subjects developed CVDs and 110 died. In the HTN group, the hazard ratio [HRs (95% confidence interval)] adjusted for age and other risk factors were 3.44 (1.95-6.09) for IHD (P value < 0.001), 1.28 (0.59-2.77) for stroke (P value = 0.536) 4.89 (1.37-17.45) for CVD mortality (P value < 0.001) and 1.70 (0.98-2.96) for all cause mortality (P value = 0.060). Although, pre-HTN significantly increased the risk of IHD incidence in the crude model (HR 2.21, 95% CI 1.23-3.97) and after adjustments for age (HR 1.85, 95% CI 1.02-3.33), (P value < 0.001) the association did not remain statistically significant after including other risk factors in the model. CONCLUSION: Hypertension (HTN) to be a strong risk factor for CVD and IHD. However, in contrast to previous researches, pre-HTN was not found to be a risk factor for CVD, IHD or death independent to other risk factors in women.

19 Article Is there any difference between non-obese male and female in response to cardiac rehabilitation programs? 2012

Sadeghi, Masoumeh / Ghashghaei, Fatemeh E / Rabiei, Katayoun / Roohafza, Hamidreza / Afshar, Hamid. ·Cardiac Rehabilitation Research Center, Isfahan Cardiovascular, Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·J Res Med Sci · Pubmed #23798948.

ABSTRACT: INTRODUCTION: Coronary artery disease (CAD) is the leading cause of death and disability all over the world. A sedentary lifestyle and dyslipidemia are known to be the major risk factors, which play an important role in the progression of coronary artery disease. Regarding gender differences, the risk of developing coronary heart disease is recognized as being different between non-obese males and non-obese females. Hence, the aim of this study is to assess the benefits of a comprehensive cardiac rehabilitation program (CRP) on the functional capacity and lipid profiles, such as, total cholesterol, triglycerides, low density lipoprotein cholesterol, and high density lipoprotein cholesterol in non-obese males and non-obese females with coronary artery disease, and comparing these groups. MATERIALS AND METHODS: We evaluated 585 non-obese males and females with coronary artery disease. All the participants completed the cardiac rehabilitation program for two months, which included 24 exercise training sessions, medical evaluation, and consultation. For investigation of the effects of the cardiac rehabilitation program on the functional capacity and lipid profiles, exercise tests were carried out by each patient, and also, their blood samples were taken on entrance and at the end of this period. RESULTS: The findings, following 24 sessions in the cardiac rehabilitation program, showed that the functional capacity (P = 0.00) and all lipid profiles had significantly improved in both the groups, except that the high density lipoprotein cholesterol did not show a significant difference in non-obese females. In addition, comparing the two groups did not show any significant differences in lipid profiles, but the changes in functional capacity were significant (P = 0.00) between the two groups, following the cardiac rehabilitation program. CONCLUSION: The CRP, which was performed by the patients under supervision of a physician and an exercise physiologist, plays a key role in improving the functional capacity (FC) and all lipid profiles in non-obese males and females with coronary artery disease, without any attention to gender differences.

20 Article Aspirin resistance and ischemic heart disease on Iranian experience. 2012

Sadeghi, Masoumeh / Emami, Afsoon / Ziyaei, Naghmeh / Yaran, Majid / Golabchi, Allahyar / Sadeghi, Azam. ·Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan, Iran. ·Adv Biomed Res · Pubmed #23210092.

ABSTRACT: BACKGROUND: Coronary artery disease (CAD) and myocardial infarction are the most common causes of mortality and morbidity all over the world. Aspirin resistance is an important part of therapeutic failure in patients who experience several atherosclerotic events despite aspirin therapy. Different studies have reported aspirin resistance between 5% and 45% all over the world. According to different responses to aspirin therapy in countries and lack of adequate studies on aspirin resistance in Iran, this study was designed for evaluation of aspirin resistance in ischemic patients. MATERIALS AND METHODS: Total 170 patients with documented coronary artery stenosis with were enrolled in this cross-sectional prospective study. Two cc urine samples were obtained from all the subjects. Then a questionnaire including questions about major risk factors (hypertension, diabetes, hyperlipidemia, obesity and smoking) was completed for each patient. Thromboxane B2 level in urine was measured two times for each patient by one kit of via ELISA method. Gensini modified was usedfor assessment of severity of coronary arteries involvement. Data were analyzed via SPSS 16. with general linear model (univariate). RESULTS: 75.3% of studied patients were aspirin resistant. There was significant relationship between angiography score and aspirin resistance (P<0.001).Our results also showed that aspirin resistance is more common in studied women than men (P=0.003).Significant correlation was observed between diabetes and aspirin resistance in studied subjects (P=0.023). CONCLUSION: Our study showed aspirin resistance in a sample of Iranian ischemic patients is so prevalent which is higher than other studies in another communities and also aspirin resistance is more common in patients with severe CAD.

21 Article Comparing the effects of a cardiac rehabilitation program on functional capacity of obese and non-obese women with coronary artery disease. 2012

Sadeghi, Masoumeh / Esteki Ghashghaei, Fatemeh / Rouhafza, Hamidreza. ·Associate Professor, Department of Cardiology, Cardiac Rehabilitation Research Center, Isfahan Cardiovascular Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran. ·ARYA Atheroscler · Pubmed #23056103.

ABSTRACT: BACKGROUND: Obesity and sedentary lifestyle are known as important risk factors of coronary artery disease. The prevalence of obesity has increased among both men and women in the world. Therefore, the present study tried to evaluate the effectiveness of a cardiac rehabilitation program on functional capacity and body mass index (BMI) in obese and non-obese women with coronary artery disease. METHODS: In an observational study during 2000-11, we evaluated a total of 205 women with coronary artery disease who referred to the cardiac rehabilitation unit of Isfahan Cardiovascular Research Institute, Isfahan, Iran. BMI and functional capacity of each patient were assessed before and after the program. The patients were categorized as obese or non-obese based on their BMI. All participants completed the full course of the program. Data was analyzed by independent t-test and paired t-test in SPSS(15). RESULTS: Our finding showed that an 8-week cardiac rehabilitation program had significant effects on functional capacity in obese and non-obese female patients (P < 0.01 for both). The program also resulted in BMI improvements in both groups (P < 0.01 for both). Comparing the changes in the two groups did not reveal any significant differences in functional capacity. However, the two groups were significantly different in terms of BMI changes. CONCLUSION: Cardiac rehabilitation programs are a major step in restoration of functional capacity and improvement of BMI in obese and non-obese women with coronary artery disease.

22 Article Evaluation of leptin and adiponectin levels in patients with stable angina pectoris. 2010

Mozafari, Masoud / Sadeghi, Masoumeh / Sanei, Hamid / Arash Ramezani, Mohammad / Golabchi, Allahyar / Sarrafzadegan, Nizal. ·Cardiology Resident, Isfahan University of Medical Sciences, Isfahan, Iran. ·ARYA Atheroscler · Pubmed #22577414.

ABSTRACT: BACKGROUND: Leptin and adiponectin are two adipose tissue hormones and their association with the incidence of cardiovascular diseases is under evaluation. The aim of this study was to determine the relationship of leptin and adiponectin with coronary artery diseases. METHODS: One hundred and seventy patients with angina pectoris and indications of coronary angiography underwent angiography. Serum levels of blood lipids, leptin, and adiponectin were measured. The gathered data was evaluated using SPSS(15) software, by multivariate variance analysis. RESULTS: Analysis of the data demonstrated that 45.1% of the patients had positive angiographic findings. The serum levels of leptin and adiponectin were significantly lower than the minimum levels specified by the kit. However, the two groups, i.e., patients with positive angiographic findings and those with negative findings were not significantly different according to the serum levels of the hormones. Moreover, no significant correlation between the serum levels of the hormones and serum lipids was observed. CONCLUSION: Various studies have demonstrated that high serum level of leptin and the incidence of coronary artery diseases are correlated. On the other hand, they have reported that adiponectin has cardioprotective role. Confirmation of these findings requires more detailed studies.