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Coronary Artery Disease: HELP
Articles by Sheng-Hsiung Sheu
Based on 15 articles published since 2008
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Between 2008 and 2019, Sheng-Hsiung Sheu wrote the following 15 articles about Coronary Artery Disease.
 
+ Citations + Abstracts
1 Article Beneficial effects of home-based cardiac rehabilitation on metabolic profiles in coronary heart-disease patients. 2016

Chen, Jing-Ting / Lin, Tsung-Hsien / Voon, Wen-Chol / Lai, Wen-Ter / Huang, Mao-Hsiung / Sheu, Sheng-Hsiung / Chen, Chun-Kai. ·Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Taiwan. · Department of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. · Department of Physical Medicine and Rehabilitation, Kaohsiung Medical University Hospital, Taiwan; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. · Department of Physical Medicine and Rehabilitation, Kaohsiung Municipal Cijin Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Graduate Institute of Medicine, Collage of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. Electronic address: 1000421@cc.kmuh.org.tw. ·Kaohsiung J Med Sci · Pubmed #27316586.

ABSTRACT: Coronary heart disease (CHD) is a major cause of morbidity and mortality in developed countries. Metabolic syndrome (MetS) is associated with increased risk of CHD. Cardiac rehabilitation is considered an effective intervention and a Class I indication in patients with CHD. This study was designed to evaluate the effects of home-based, integrated cardiac rehabilitation (HBICR) of patients with CHD in modifiable risk-factor control and exercise capacity. Sixty-four patients with CHD were investigated and randomized into intervention and control groups. The intervention group received a HBICR containing medication use, exercise program, smoking-cessation counseling, and education regarding risk factors, nutrition, and the necessity of continuing the program, whereas the control group received traditional care. Baseline and follow-up assessments at 3 months and 12 months, including body composition, metabolic syndrome risk score, and biochemical tests were performed in all patients. Additionally, cardiopulmonary function tests were also performed at baseline and 3-month follow-up assessments. There was a significant between-group, within-group, and interaction effect found in the MetS Z scores. Significant within-group effects were also observed in modified Adult Treatment Panel III score, waist circumference, high-density lipoprotein, and low-density lipoprotein. However, several cardiopulmonary parameters did not differ significantly at 3-month follow-up between the two groups, including peak V̇O2, peak heart rate, peak respiratory exchange ratio, anaerobic threshold V̇O2, heart-rate reserve, and heart-rate recovery after 1 min and after 2 min. Our results showed that HBICR exhibited significant positive effects on modifiable risk-factor control in CHD patients.

2 Article Cardiovascular events in patients with atherothrombotic disease: a population-based longitudinal study in Taiwan. 2014

Lee, Wen-Hsien / Hsu, Po-Chao / Chu, Chun-Yuan / Su, Ho-Ming / Lee, Chee-Siong / Yen, Hsueh-Wei / Lin, Tsung-Hsien / Voon, Wen-Chol / Lai, Wen-Ter / Sheu, Sheng-Hsiung. ·Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. · Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. · Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. · Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. ·PLoS One · Pubmed #24647769.

ABSTRACT: BACKGROUND: Atherothrombotic diseases including cerebrovascular disease (CVD), coronary artery disease (CAD), and peripheral arterial disease (PAD), contribute to the major causes of death in the world. Although several studies showed the association between polyvascular disease and poor cardiovascular (CV) outcomes in Asian population, there was no large-scale study to validate this relationship in this population. METHODS AND RESULTS: This retrospective cohort study included patients with a diagnosis of CVD, CAD, or PAD from the database contained in the Taiwan National Health Insurance Bureau during 2001-2004. A total of 19954 patients were enrolled in this study. The atherothrombotic disease score was defined according to the number of atherothrombotic disease. The study endpoints included acute coronary syndrome (ACS), all strokes, vascular procedures, in hospital mortality, and so on. The event rate of ischemic stroke (18.2%) was higher than that of acute myocardial infarction (5.7%) in our patients (P = 0.0006). In the multivariate Cox regression analyses, the adjusted hazard ratios (HRs) of each increment of atherothrombotic disease score in predicting ACS, all strokes, vascular procedures, and in hospital mortality were 1.41, 1.66, 1.30, and 1.14, respectively (P≦0.0169). CONCLUSIONS: This large population-based longitudinal study in patients with atherothrombotic disease demonstrated the risk of subsequent ischemic stroke was higher than that of subsequent AMI. In addition, the subsequent adverse CV events including ACS, all stroke, vascular procedures, and in hospital mortality were progressively increased as the increase of atherothrombotic disease score.

3 Article Coronary collateral circulation in patients of coronary ectasia with significant coronary artery disease. 2014

Hsu, Po-Chao / Su, Ho-Ming / Lee, Hsiang-Chun / Juo, Suh-Hang / Lin, Tsung-Hsien / Voon, Wen-Chol / Lai, Wen-Ter / Sheu, Sheng-Hsiung. ·Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan ; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. · Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan ; Department of Internal Medicine, Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan. · Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. · Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Medical Genetics, Kaohsiung Medical University, Kaohsiung, Taiwan ; Center of Excellence for Environmental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. · Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan ; Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. ·PLoS One · Pubmed #24475209.

ABSTRACT: OBJECTIVES: Patients with coronary ectasia (CE) usually have coexisting coronary stenosis resulting in myoischemia. Coronary collateral plays an important role in protecting myocardium from ischemia and reducing cardiovascular events. However, limited studies investigate the role of CE in coronary collaterals development. METHODS: We evaluated 1020 consecutive patients undergoing coronary angiography and 552 patients with significant coronary artery disease (SCAD), defined as diameter stenosis more than 70%, were finally analyzed. CE is defined as the ectatic diameter 1.5 times larger than adjacent reference segment. Rentrop collateral score was used to classify patients into poor (grades 0 and 1) or good (grades 2 and 3) collateral group. RESULTS: 73 patients (13.2%) had CE lesions which were most located in the right coronary artery (53.4%). Patients with CE had a lower incidence of diabetes (43.8% vs 30.1%, p = 0.03), higher body mass index (25.4±3.5 vs 26.7±4.6, p = 0.027) and poorer coronary collateral (58.2% vs 71.2%, p = 0.040). Patients with poor collateral (n = 331) had a higher incidence of CE (15.7% vs 9.5%, p = 0.040) and fewer diseased vessels numbers (1.96±0.84 vs 2.48±0.69, p<0.001). Multivariate analysis showed diabetes (odd ratio (OR) 0.630, p = 0.026), CE (OR = 0.544, p = 0.048), and number of diseased vessels (OR = 2.488, p<0.001) were significant predictors of coronary collaterals development. CONCLUSION: The presence of CE was associated with poorer coronary collateral development in patients with SCAD.

4 Article The hOGG1 Ser326Cys gene polymorphism and the risk of coronary ectasia in the Chinese population. 2014

Hsu, Po-Chao / Wang, Chiao-Ling / Su, Ho-Ming / Juo, Suh-Hang / Lin, Tsung-Hsien / Voon, Wen-Chol / Shin, Shyi-Jang / Lai, Wen-Ter / Sheu, Sheng-Hsiung. ·Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. pochao.hsu@gmail.com. · Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. bizibear@pchome.com.tw. · Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. cobeshm@seed.net.tw. · Department of Medical Research, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. hjuo@kmu.edu.tw. · Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. lth@kmu.edu.tw. · Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. d750078@kmu.edu.tw. · Department of Internal Medicine, Faculty of Medicine, Kaohsiung Medical University, Kaohsiung 80708, Taiwan. sjshin@cc.kmu.edu.tw. · Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. wtlai@cc.kmu.edu.tw. · Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung 80708, Taiwan. sheush@cc.kmu.edu.tw. ·Int J Mol Sci · Pubmed #24451144.

ABSTRACT: Oxidative stress (OS) is related to vascular inflammation possibly, contributing to the development of coronary ectasia (CE). Base excision repair (BER) and nucleotide excision repair are the main DNA repair pathways that can help to remove 8-hydroxydeoxyguanine (8-OHdG), a marker of OS. Human 8-oxoguanine DNA glycosylase 1 (hOGG1) is a key enzyme of the BER pathway and catalyzes the removal of 8-OHdG. The aim of our study was to investigate the association between hOGG1 Ser326Cys gene polymorphism and CE in a Chinese population. Five-hundred forty-seven patients who underwent diagnostic coronary angiography in a tertiary medical center were recruited. The angiographic definition of CE is the diameter of the ectatic segment being more than 1.5 times larger compared with an adjacent healthy reference segment. The gene polymorphisms were analyzed by polymerase chain reaction. The urine 8OHdG concentration was measured using a commercial ELISA kit. The distribution of hOGG1 Ser326Cys genotypes was significantly different between CE and non-CE groups (p = 0.033). The odds ratio of CE development for the Ser to the Cys variant was 1.55 (95% confidence interval (CI), 1.04-2.31, p = 0.033). Both univariate and logistic regression analysis showed a significant association of hOGG1 Ser326Cys polymorphism in the dominant model with CE development (p = 0.009 and 0.011, respectively). Urine 8-OHdG levels were significantly higher in subjects carrying the hOGG1 Ser variant than in those with the Cys/Cys genotype (p < 0.03). In conclusion, our study suggests that the hOGG1 Ser326Cys gene variant might play a role in susceptibility to the development of CE.

5 Article Influence of high-density lipoprotein cholesterol on coronary collateral formation in a population with significant coronary artery disease. 2013

Hsu, Po-Chao / Su, Ho-Ming / Juo, Suh-Hang / Yen, Hsueh-Wei / Voon, Wen-Chol / Lai, Wen-Ter / Sheu, Sheng-Hsiung / Lin, Tsung-Hsien. ·Department of Internal Medicine, Division of Cardiology, Kaohsiung Medical University, 100 Tzyou 1st Road, Kaohsiung, 80708, Taiwan, ROC. ·BMC Res Notes · Pubmed #23510196.

ABSTRACT: BACKGROUND: Coronary collateral circulation plays an important role in protecting myocardium from ischemia and reducing cardiovascular events. Low High-density lipoprotein cholesterol (HDL-C) level is a strong risk factor for coronary artery disease (CAD) and is associated with poor cardiovascular outcome. It was recently reported to be associated with poor coronary collateral development in Turkish population. Hence, we investigated the influence of HDL-C on coronary collateral formation in Chinese population. METHODS: We evaluated 970 consecutive patients undergoing coronary angiography, and 501 patients with significant coronary artery disease (SCAD) were finally analyzed. The collateral scoring system developed by Rentrop was used to classify patient groups as those with poor or good collaterals. RESULTS: The patients with poor collaterals had fewer diseased vessels (1.97 ± 0.84 vs 2.47 ± 0.68, p < 0.001) and lower diffuse score (2.65 ± 1.63 vs 3.76 ± 1.78, p < 0.001). There was no significant difference in HDL-C and other variables between good and poor collaterals. Multivariate analysis showed only number of diseased vessels (odd ratio 0.411, p < 0.001) was a significant predictor of poor collateral development. CONCLUSIONS: The extent of CAD severity but not HDL-C level was the most powerful predictor of coronary collateral formation in our Chinese population with SCAD.

6 Article Predictor of poor coronary collaterals in elderly population with significant coronary artery disease. 2013

Hsu, Po-Chao / Juo, Suh-Hang / Su, Ho-Ming / Tsai, Wei-Chung / Voon, Wen-Chol / Lai, Wen-Ter / Sheu, Sheng-Hsiung / Lin, Tsung-Hsien. ·Division of Cardiology (P-CH, HMS, H-MS, W-CT, W-CV, W-TL, S-HS, T-HL), Department of Internal Medicine and Department of Medical Research (S-HJ), Kaohsiung Medical University Hospital, Kaohsiung, Taiwan · Department of Internal Medicine (H-MS, W-CV, W-TL, T-HL), Faculty of Medicine, Graduate Institute of Medicine (P-CH), Medical Genetics (S-HJ), and Center of Excellence for Environmental Medicine (S-HJ, S-HS), Kaohsiung Medical University, Kaohsiung, Taiwan · and Department of Internal Medicine (H-MS), Kaohsiung Municipal Hsiao-Kang Hospital, Kaohsiung, Taiwan. ·Am J Med Sci · Pubmed #23221513.

ABSTRACT: BACKGROUND: Coronary collateral circulation plays an important role in protecting myocardium from ischemia and reducing cardiovascular events. Advanced age might be associated with poor coronary collateral development and cardiovascular outcome. However, limited studies investigate the predictors for collateral development in the elderly population. METHODS: The authors evaluated 950 consecutive patients undergoing coronary angiography and finally analyzed 207 patients of 65 years or more. The collateral scoring system developed by Rentrop was used to classify patients into those with poor or good collateral formation. RESULTS: The patients with poor collateral were older age, had lower incidence of smoking, more male sex, had fewer diseased vessels and had a trend to be diabetic. Multivariate analysis showed age (odds ratio (OR) = 1.068; P = 0.019), diabetes (OR = 2.681; P = 0.003) and diseased vessels numbers (OR = 0.337; P < 0.001) were significant predictors of poor collaterals development. Furthermore, age and diabetes have a synergistic effect on poor collateral development (P = 0.041 for interaction). CONCLUSIONS: Even in the elderly population, age and diabetes might negatively influence the coronary collaterals development.

7 Article Predictor of poor coronary collaterals in chronic kidney disease population with significant coronary artery disease. 2012

Hsu, Po-Chao / Juo, Suh-Hang / Su, Ho-Ming / Chen, Szu-Chia / Tsai, Wei-chung / Lai, Wen-Ter / Sheu, Sheng-Hsiung / Lin, Tsung-Hsien. ·Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, 100 Tzyou 1st Road, Kaohsiung, 80708, Taiwan, ROC. ·BMC Nephrol · Pubmed #22935602.

ABSTRACT: BACKGROUND: Coronary collateral circulation plays an important role to protect myocardium from ischemia, preserve myocardial contractility and reduce cardiovascular events. Chronic kidney disease (CKD) is associated with poor coronary collateral development and cardiovascular outcome. However, limited research investigates the predictors for collateral development in the CKD population. METHODS: We evaluated 970 consecutive patients undergoing coronary angiography and 202 patients with CKD, defined as a glomerular filtration rate less than 60 ml/min/1.73 m2, were finally analyzed. The collateral scoring system developed by Rentrop was used to classify patients into poor (grades 0 and 1) or good (grades 2 and 3) collateral group. RESULTS: The patients with poor collateral (n = 122) had a higher incidence of hypertension (82% vs 63.8%, p = 0.005), fewer diseased vessels numbers (2.1 ± 0.9 vs 2.6 ± 0.6, p < 0.001) and a trend to be diabetic (56.6% vs. 43.8%, p = 0.085) or female sex (37.7% vs. 25.0%, p = 0.067). Multivariate analysis showed hypertension (odd ratio (OR) 2.672, p = 0.006), diabetes (OR 1.956, p = 0.039) and diseased vessels numbers (OR 0.402, p < 0.001) were significant predictors of poor coronary collaterals development. Furthermore, hypertension and diabetes have a negative synergistic effect on collateral development (p = 0.004 for interaction). CONCLUSIONS: In the CKD population hypertension and diabetes might negatively influence the coronary collaterals development.

8 Article Chewing areca nut increases the risk of coronary artery disease in Taiwanese men: a case-control study. 2012

Tsai, Wei-Chung / Wu, Ming-Tsang / Wang, Guei-Jane / Lee, Kun-Tai / Lee, Chien-Hung / Lu, Ye-Hsu / Yen, Hsueh-Wei / Chu, Chih-Sheng / Chen, Yi-Ting / Lin, Tsung-Hsien / Su, Ho-Ming / Hsu, Po-Chao / Cheng, Kai-Hung / Duh, Tsai-Hui / Ko, Ying-Chin / Sheu, Sheng-Hsiung / Lai, Wen-Ter. ·Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. ·BMC Public Health · Pubmed #22397501.

ABSTRACT: BACKGROUND: Areca nut chewing has been reported to be associated with obesity, metabolic syndrome, hypertension, and cardiovascular mortality in previous studies. The aim of this study was to examine whether chewing areca nut increases the risk of coronary artery disease (CAD) in Taiwanese men. METHODS: This study is a hospital-based case-control study. The case patients were male patients diagnosed in Taiwan between 1996 and 2009 as having a positive Treadmill exercise test or a positive finding on the Thallium-201 single-photon emission computed tomography myocardial perfusion imaging. The case patients were further evaluated by coronary angiography to confirm their CAD. Obstructive CAD was defined as a ≥ 50% decrease in the luminal diameter of one major coronary artery. The patients who did not fulfill the above criteria of obstructive CAD were excluded.The potential controls were males who visited the same hospital for health check-ups and had a normal electrocardiogram but no history of ischemic heart disease or CAD during the time period that the case patients were diagnosed. The eligible controls were randomly selected and frequency-matched with the case patients based on age. Multiple logistic regression analyses were used to estimate the odds ratio of areca nut chewing and the risk of obstructive CAD. RESULTS: A total of 293 obstructive CAD patients and 720 healthy controls, all men, were analyzed. Subjects who chewed areca nut had a 3.5-fold increased risk (95% CI = 2.0-6.2) of having obstructive CAD than those without, after adjusting for other significant covariates. The dose-response relationship of chewing areca nut and the risk of obstructive CAD was also noted. After adjusting for other covariates, the 2-way additive interactions for obstructive CAD risk were also significant between areca nut use and cigarette smoking, hypertension and dyslipidemia. CONCLUSIONS: Long-term areca nut chewing was an independent risk factor of obstructive CAD in Taiwanese men. Interactive effects between chewing areca nut and cigarette smoking, hypertension, and dyslipidemia were also observed for CAD risk. Further exploration of their underlying mechanisms is necessary.

9 Article Postchallenge responses of nitrotyrosine and TNF-alpha during 75-g oral glucose tolerance test are associated with the presence of coronary artery diseases in patients with prediabetes. 2012

Chu, Chih-Sheng / Lee, Kun-Tai / Cheng, Kai-Hong / Lee, Min-Yi / Kuo, Hsuan-Fu / Lin, Tsung-Hsien / Su, Ho-Ming / Voon, Wen-Chol / Sheu, Sheng-Hsiung / Lai, Wen-Ter. ·Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. ·Cardiovasc Diabetol · Pubmed #22397368.

ABSTRACT: BACKGROUND: Meta-analysis has demonstrated an exponential relationship between 2-hr postchallenge hyperglycemia and coronary artery disease (CAD). Pulsatile hyperglycemia can acutely increase proinflammatory cytokines by oxidative stress. We hypothesized that postchallenge proinflammatory and nitrosative responses after 75 g oral glucose tolerance tests (75 g-OGTT) might be associated with CAD in patients without previously recognized type 2 diabetes mellitus (T2DM). METHODS: Serial changes of plasma glucose (PG), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) and nitrotyrosine levels were analyzed during 75 g-OGTT in 120 patients (81 male; age 62 ± 11 years) before coronary angiography. Patients were classified as normal (NGT; 42%), impaired (IGT; 34%) and diabetic (T2DM; 24%) glucose tolerance by 75 g-OGTT. RESULTS: Postchallenge hyperglycemia elicited TNF-α, IL-6 and nitrotyrosine levels time-dependently, and 2-hr median levels of TNF-α (7.1 versus 6.4 pg/ml; P < 0.05) and nitrotyrosine (1.01 versus 0.83 μmol/l; P < 0.05), but not IL-6 or PG, were significantly higher in patients with CAD in either IGT or T2DM groups. After adjusting risk factors and glucose tolerance status, 2-hr nitrotyrosine in highest quartiles (OR: 3.1, P < 0.05) remained an independent predictor of CAD by logistic regression analysis. CONCLUSIONS: These results highlight postchallenge proinflammatory and nitrosative responses by 75 g-OGTT, rather than hyperglycemia per se, are associated with CAD in patients without previous recognized diabetes.

10 Article Synergistic effect between BRAP polymorphism and diabetes on the extent of coronary atherosclerosis in the Chinese population. 2011

Hsu, Po-Chao / Lin, Tsung-Hsien / Su, Ho-Ming / Juo, Suh-Hang Hank / Lai, Wen-Ter / Sheu, Sheng-Hsiung. ·Division of Cardiology, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. ·Cardiology · Pubmed #22085839.

ABSTRACT: OBJECTIVES: Coronary artery disease (CAD) is a multifactorial disease and influenced by genetics. We previously reported that a single nucleotide polymorphism (rs11066001) in the BRAP gene was related to the risk of myocardial infarction. However, it is unclear whether rs11066001 is associated with the extent of coronary atherosclerosis. METHODS: We enrolled 732 patients scheduled for diagnostic coronary angiography. Angiographic presence of significant CAD (0 or 1), clinical vessel score (CVS, 0-3 vessels) and diffuse score (DS, 0-11.5) were used to evaluate the extent of coronary atherosclerosis. Genotyping was carried out by the TaqMan technology. RESULTS: Of all patients, 558 (76.2%) had significant CAD. The odds ratio for the GG to the AA genotype was 2.45 (95% CI 1.13-5.34, p = 0.024) for the presence of significant CAD. The CVS was correlated with the frequency of genotypes in the recessive model (p = 0.001). Regression analysis showed a significant association between rs11066001 and the presence of significant CAD and DS (all p < 0.05). There was a synergistic effect between rs11066001 and diabetes on the occurrence of significant CAD (p < 0.001 for interaction). CONCLUSION: The BRAP rs11066001 gene is associated with the extent of coronary atherosclerosis and has a synergistic effect with diabetes on the occurrence of significant CAD in the Chinese population.

11 Article The 8-oxoguanine glycosylase I (hOGG1) Ser326Cys variant affects the susceptibility to multi-vessel disease in Taiwan coronary artery disease patients. 2010

Wang, Chiao-Ling / Lin, Tsung-Hsien / Lin, Hsing-Yi / Sheu, Sheng-Hsiung / Yu, Ming-Lung / Hsiao, Pi-Jung / Lin, Kun-Der / Hsu, Chin / Yang, Yi-Hsin / Shin, Shyi-Jang. ·Graduate Institute of Medicine, Faculty of Medicine, College of Medicine, Kaohsiung Medical University, Taiwan, ROC. ·Thromb Res · Pubmed #20667409.

ABSTRACT: 8-hydroxydeoxyguanosine, the key lesion of oxidative DNA damage, contributes to the development of coronary artery disease (CAD). In humans, 8-hydroxydeoxyguanosine is repaired by the enzyme 8-oxoguanine glycosylase I (hOGG1). We investigated the association between the hOGG1 Ser(326)Cys polymorphism and the presence and the severity of CAD in a Taiwan population. Genotypes of the hOGG1 Ser(326)Cys polymorphism were determined from 1397 participants enrolled in this study (378 CAD patients and 1019 controls). CAD severity was indicated both by number of vessels affected (single-vessel disease, SVD vs. multi-vessel disease, MVD), and by individual diffuse score. Real-time polymerase chain reaction was used to determine genotype, using allele-specific TaqMan probes. We found that presence of the hOGG1 Ser(326)Cys polymorphism was associated with a significantly increased risk of CAD and multi-vessel disease when assuming a dominant model of inheritance (OR: 1.52 [95%:1.082~2.133], p=0.015; OR: 2.26 [95%:1.232~4.156], p=0.007). This result was confirmed by multivariate analysis, after adjustment for age, gender, body-mass index, diabetes hypertension, hypercholesterolemia and smoking (OR: 1.78 [95%:1.127~2.806], p<0.005; OR: 2.44 [95%:1.276~4.651], p<0.001). In the present study, hOGG1 Ser(326)Cys polymorphism is a novel genetic marker to be independently associated with the development and severity of CAD in Taiwanese population.

12 Article Acute myocardial infarction with simultaneous involvement of right coronary artery and left anterior descending artery: a case report. 2010

Lee, Wen-Hsien / Hsu, Po-Chao / Lin, Tsung-Hsien / Su, Ho-Ming / Lai, Wen-Ter / Sheu, Sheng-Hsiung. ·Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. ·Kaohsiung J Med Sci · Pubmed #20638042.

ABSTRACT: Acute myocardial infarction is usually caused by rupture of unstable plaque and involves a single coronary artery. Simultaneous occlusions of multiple coronary arteries in patients with ST elevation myocardial infarction are uncommon and lead to a fatal outcome. We report a 75-year-old male presenting with persistent chest pain complicated by ventricular fibrillation. After defibrillation and cardiopulmonary resuscitation, an emergency coronary angiogram showed total occlusion of the right coronary artery, and thrombus in the proximal left anterior descending artery. Both coronary arteries underwent successful balloon inflation and stenting. The patient finally survived under ventilatory support. This rare case suggests that aggressive reperfusion therapy and even mechanical support to improve poor clinical outcome are suggested in high risk patients with multivessel occlusions.

13 Article Functional vascular endothelial growth factor gene polymorphisms and diabetes: effect on coronary collaterals in patients with significant coronary artery disease. 2010

Lin, Tsung-Hsien / Wang, Chiao-Ling / Su, Ho-Ming / Hsu, Po-Chao / Juo, Suh-Hang Hank / Voon, Wen-Chol / Shin, Shyi-Jang / Lai, Wen-Ter / Sheu, Sheng-Hsiung. ·Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Taiwan. ·Clin Chim Acta · Pubmed #20621071.

ABSTRACT: BACKGROUND: Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis. This study tested the association between functional VEGF +405 C>G (rs2010963), -2578C>A (rs699947) polymorphisms, and coronary collaterals in patients with coronary artery disease (CAD). METHOD: The collateral scoring system developed by Rentrop was used to classify 393 patients according to their collaterals as either "poor" (grades 0 and 1) or "good" (grades 2 and 3). Gene polymorphisms were analyzed by TaqMan assay. RESULTS: The frequency of +405C and -2578A alleles was higher in the good collaterals group (p=0.007 and 0.005, respectively). For the +405C>G allele, the odds ratio (OR) of good collaterals for CC to GG genotype was 2.54 (p=0.003). For the -2578A allele, the OR of good collaterals for AA to CC genotype was 2.31 (p=0.038). Univariate and logistic regression analysis found 2 polymorphisms in the additive model for associations with collateral development: +405C>G (p=0.005 and 0.010) and -2578C>A (p=0.006 and 0.006). The VEGF +405C>G polymorphism and DM revealed an interactive effect on collateral development (p=0.027). CONCLUSIONS: The VEGF +405C>G and -2578C>A polymorphisms might be novel genetic factors affecting collateral development in Chinese patients.

14 Article Vascular endothelial growth factor polymorphisms and extent of coronary atherosclerosis in Chinese population with advanced coronary artery disease. 2010

Lin, Tsung-Hsien / Su, Ho-Ming / Wang, Chiao-Ling / Voon, Wen-Chol / Shin, Shyi-Jang / Lai, Wen-Ter / Sheu, Sheng-Hsiung. ·Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan. ·Am J Hypertens · Pubmed #20489684.

ABSTRACT: BACKGROUND: Vascular endothelial growth factor (VEGF) is important in atherosclerotic development. We examined two VEGF polymorphisms, including +405 C/G (rs2010963) and -2578C/A (rs699947), to assess their relation to the extent of coronary atherosclerosis. METHODS: We recruited 398 patients with advanced coronary artery disease (CAD). Angiographic "clinical vessel score" (CVS, 1-3 vessels) and "diffuse score" (DS, 0-11.5) were used to evaluate the extent of coronary atherosclerosis. CVS are further categorized into single- (SVD) and multi-vessel disease (MVD: 2 and 3 vessels). Genotyping was performed by TaqMan assay. RESULTS: The frequency of +405 C/G genotype was correlated with CVS and DS (P = 0.016 and 0.016, respectively). The +405C allele frequency was significantly increased in patients with MVD (P = 0.020). The odds ratio (OR) for the CC to the GG genotype was 2.92 (95% confidence interval (CI): 1.31-6.55, P = 0.007). Univariate and logistic regression analysis showed a significant independent association of +405 C/G genotype with SVD/MVD (P = 0.010 and 0.015, respectively) in the recessive model. Furthermore, there is a synergistic effect of CC genotype and diabetes on the occurrence of MVD (P = 0.001 for interaction). There is also a significant independent association of +405 C/G genotype in the recessive model with DS in the uni- and multivariate regression analysis (P = 0.013 and 0.005, respectively). No association was found between VEGF -2578C/A polymorphism and both atherosclerotic parameters. CONCLUSIONS: The VEGF +405C/G polymorphism is a novel genetic factor to influence the extent of coronary atherosclerosis in the Chinese CAD population.

15 Article Usefulness of the ratio of transmitral E wave velocity to isovolumic relaxation flow propagation velocity for predicting left ventricular end-diastolic pressure. 2008

Su, Ho-Ming / Lin, Tsung-Hsien / Lee, Chee-Siong / Lin, Chien-Tsai / Tang, Min-Hua / Chin, Tan-Tze / Lai, Wen-Ter / Sheu, Sheng-Hsiung / Voon, Wen-Chol. ·Division of Cardiology, Department of Internal Medicine, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung, Taiwan. ·Ultrasound Med Biol · Pubmed #18538465.

ABSTRACT: Transmitral E wave velocity was reported to be positively related to left ventricular (LV) filling pressure and negatively related to LV relaxation constant, and isovolumic relaxation flow propagation velocity (IRFPV) was proven recently to be negatively related to LV relaxation constant and independent of preload alterations. Therefore, the combination index, E/IRFPV, may eliminate the influence of LV relaxation and bring the LV filling pressure into focus. However, it is unknown whether E/IRFPV is a useful index in prediction of LV filling pressure. The aim of this study is to evaluate the correlation between E/IRFPV and LV end-diastolic pressure (LVEDP). Forty-three patients with suspected coronary artery disease who underwent a Doppler echocardiographic study and cardiac catheterization were included. LVEDP was determined by a micromanometer-tipped catheter. In a univariate analysis, LVEDP had a positive correlation with left atrial dimension, LV end-diastolic dimension, LV end-systolic dimension, the ratio of E to E wave propagation velocity (EPV) (r = 0.408, p = 0.007), the ratio of E to early diastolic mitral annular velocity (Ea) (r = 0.439, p = 0.003) and E/IRFPV (r = 0.686, p < 0.001). It had a negative correlation with diastolic blood pressure, E wave deceleration time, LV ejection fraction, EPV, Ea and IRFPV. After stepwise multiple linear regression analysis, only the E/IRFPV was the independent predictor of LVEDP (beta = 0.667, p < 0.001). In conclusion, E/IRFPV is a useful parameter in prediction of LVEDP.