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Coronary Artery Disease: HELP
Articles by Milorad Tesic
Based on 3 articles published since 2008
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Between 2008 and 2019, Milorad Tesic wrote the following 3 articles about Coronary Artery Disease.
 
+ Citations + Abstracts
1 Article Increased left ventricular mass index is present in patients with type 2 diabetes without ischemic heart disease. 2018

Seferovic, Jelena P / Tesic, Milorad / Seferovic, Petar M / Lalic, Katarina / Jotic, Aleksandra / Biering-Sørensen, Tor / Giga, Vojislav / Stankovic, Sanja / Milic, Natasa / Lukic, Ljiljana / Milicic, Tanja / Macesic, Marija / Gajovic, Jelena Stanarcic / Lalic, Nebojsa M. ·Clinic of Endocrinology, Diabetes and Metabolic disorders, Clinical Center of Serbia, Dr. Subotica 13, 11000, Belgrade, Serbia. jpseferovic@gmail.com. · University of Belgrade, Faculty of Medicine, Belgrade, Serbia. jpseferovic@gmail.com. · Clinic of Cardiology, Clinical Center of Serbia, Koste Todorovica 8, 11000, Belgrade, Serbia. · University of Belgrade, Faculty of Medicine, Belgrade, Serbia. · Clinic of Endocrinology, Diabetes and Metabolic disorders, Clinical Center of Serbia, Dr. Subotica 13, 11000, Belgrade, Serbia. · Department of Cardiology, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. · Center for Medical Biochemistry, Clinical Center of Serbia, Visegradska 26, 11000, Belgrade, Serbia. · Institute of Medical Statistics, Faculty of Medicine, Dr. Subotića 15, Belgrade, Serbia. ·Sci Rep · Pubmed #29343820.

ABSTRACT: Left ventricular mass index (LVMI) increase has been described in hypertension (HTN), but less is known about its association with type 2 diabetes (T2DM). As these conditions frequently co-exist, we investigated the association of T2DM, HTN and both with echocardiographic parameters, and hypothesized that patients with both had highest LVMI, followed by patients with only T2DM or HTN. Study population included 101 T2DM patients, 62 patients with HTN and no T2DM, and 76 patients with T2DM and HTN, excluded for ischemic heart disease. Demographic and clinical data, biochemical measurements, stress echocardiography, transthoracic 2D Doppler and tissue Doppler echocardiography were performed. Multivariable logistic regression was used to determine the independent association with T2DM. Linear regression models and Pearson's correlation were used to assess the correlations between LVMI and other parameters. Patients with only T2DM had significantly greater LVMI (84.9 ± 20.3 g/m

2 Article Prognostic value of calcium score and coronary flow velocity reserve in asymptomatic diabetic patients. 2015

Dikic, Miodrag / Tesic, Milorad / Markovic, Zeljko / Giga, Vojislav / Djordjevic-Dikic, Ana / Stepanovic, Jelena / Beleslin, Branko / Jovanovic, Ivana / Mladenovic, Ana / Seferovic, Jelena / Ostojic, Miodrag / Arandjelovic, Aleksandra. ·Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, 11000, Belgrade, Serbia. miodrag.dikic@gmail.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, 11000, Belgrade, Serbia. misa.tesic@gmail.com. · Medical School, University of Belgrade, Belgrade, Serbia. dr.markovic@gmail.com. · Clinic for Radiology, Clinical Center of Serbia, Belgrade, Serbia. dr.markovic@gmail.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, 11000, Belgrade, Serbia. voja2011@yahoo.com. · Medical School, University of Belgrade, Belgrade, Serbia. voja2011@yahoo.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, 11000, Belgrade, Serbia. skali.ana7@gmail.com. · Medical School, University of Belgrade, Belgrade, Serbia. skali.ana7@gmail.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, 11000, Belgrade, Serbia. jelena.stepanovic@kcs.ac.rs. · Medical School, University of Belgrade, Belgrade, Serbia. jelena.stepanovic@kcs.ac.rs. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, 11000, Belgrade, Serbia. branko.beleslin@gmail.com. · Medical School, University of Belgrade, Belgrade, Serbia. branko.beleslin@gmail.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, 11000, Belgrade, Serbia. ivana170679@gmail.com. · Clinic for Radiology, Clinical Center of Serbia, Belgrade, Serbia. anicak@yahoo.com. · Medical School, University of Belgrade, Belgrade, Serbia. jpseferovic@gmail.com. · Clinic for Endocrinology, Clinical Center of Serbia, Belgrade, Serbia. jpseferovic@gmail.com. · Medical School, University of Belgrade, Belgrade, Serbia. mostojic2003@yahoo.com. · Medical School, University of Belgrade, Belgrade, Serbia. drarandjelovic@yahoo.com. · Cardiology Department, Clinical Hospital Zvezdara, Belgrade, Serbia. drarandjelovic@yahoo.com. ·Cardiovasc Ultrasound · Pubmed #26340922.

ABSTRACT: BACKGROUND: The risk stratification of patients with diabetes mellitus (DM) is a major objective for the clinicians, and it can be achieved by coronary flow velocity reserve (CFVR) or with coronary artery calcium score (CS). CS evaluates underlying coronary atherosclerotic plaque burden and CFVR estimates both presence of coronary artery stenosis and microvascular function. Consequently, CFVR may provide unique risk information beyond the extent of coronary atherosclerosis. AIM: Our aim is to assess joint prognostic value of CFVR and CS in asymptomatic DM patients. MATERIALS AND METHODS: We prospectively included 200 asymptomatic patients (45,5 % male, mean age 57,35 ± 11,25), out of which, there were 101 asymptomatic patients with DM and 99 asymptomatic patients without DM, but with one or more conventionally risk factors for coronary artery disease. We analyzed clinical, biochemical, metabolic, inflammatory parameters, CS by Agatston method, transthoracic Doppler echocardiography CFVR of left anterior descending artery and echocardiographic parameters. RESULTS: Total CS and CS LAD were significantly higher, while mean CFVR was lower in diabetics compared to the nondiabetics. During 1 year follow-up, 24 patients experienced cardio-vascular events (one cardiovascular death, two strokes, three myocardial infarctions, nine new onsets of unstable angina and nine myocardial revascularizations): 19 patients with DM and five non DM patients, (p = 0,003). Overall event free survival was significantly higher in non DM group, compared to the DM group (94,9 % vs. 81,2 %, p = 0,002 respectively), while the patients with CS ≥200 and CFVR <2 had the worst outcome during 1 year follow up in the whole study population as well as in the DM group. At multivariable analysis CFVR on LAD (HR 12.918, 95 % CI 3.865-43.177, p < 0.001) and total CS (HR 13.393, 95 % CI 1.675-107.119, p = 0.014) were independent prognostic predictors of adverse events in DM group of patients. CONCLUSION: Both CS and CFVR provide independent and complementary prognostic information in asymptomatic DM patients. When two parameters are analyzed together, the risk stratification ability improves, even when DM patients are analyzed together with non DM patients. As a result, DM patients with CS ≥200 and CFVR <2 had the worst outcome. Consequently, the use of two tests identified subset of patients who can derive the most benefit from the intensive prevention measures.

3 Article The effects of nicorandil on microvascular function in patients with ST segment elevation myocardial infarction undergoing primary PCI. 2015

Kostic, Jelena / Djordjevic-Dikic, Ana / Dobric, Milan / Milasinovic, Dejan / Nedeljkovic, Milan / Stojkovic, Sinisa / Stepanovic, Jelena / Tesic, Milorad / Trifunovic, Zoran / Zamaklar-Tifunovic, Danijela / Radosavljevic-Radovanovic, Mina / Ostojic, Miodrag / Beleslin, Branko. ·Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. jesikakostic@yahoo.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. skali.ana7@gmail.com. · Medical School, University of Belgrade, Belgrade, Serbia. skali.ana7@gmail.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. iatros007@gmail.com. · Medical School, University of Belgrade, Belgrade, Serbia. iatros007@gmail.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. dejan_milasinovic@yahoo.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. milanned@hotmail.com. · Medical School, University of Belgrade, Belgrade, Serbia. milanned@hotmail.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. sstojkovi@open.telekom.rs. · Medical School, University of Belgrade, Belgrade, Serbia. sstojkovi@open.telekom.rs. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. jelena.stepanovic@kcs.ac.rs. · Medical School, University of Belgrade, Belgrade, Serbia. jelena.stepanovic@kcs.ac.rs. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. misa.tesic@gmail.com. · Military Medical Academy, Belgrade, Serbia. drtrifun@yahoo.com. · Medical Faculty, University of Defense, Belgrade, Serbia. drtrifun@yahoo.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. danijelatrif@gmail.com. · Medical School, University of Belgrade, Belgrade, Serbia. danijelatrif@gmail.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. radovanovicn@sbb.rs. · Medical School, University of Belgrade, Belgrade, Serbia. radovanovicn@sbb.rs. · Medical School, University of Belgrade, Belgrade, Serbia. mostojic2011@gmail.com. · Clinic for Cardiology, Clinical Center of Serbia, Visegradska 26, Belgrade, Serbia. branko.beleslin@gmail.com. · Medical School, University of Belgrade, Belgrade, Serbia. branko.beleslin@gmail.com. ·Cardiovasc Ultrasound · Pubmed #26012474.

ABSTRACT: BACKGROUND: Nicorandil, as a selective potassium channel opener, has dual action including coronary and peripheral vasodilatation and cardioprotective effect through ischemic preconditioning. Considering those characteristics, nicorandil was suggested to reduce the degree of microvascular dysfunction. METHODS: Thirty-two patients with ST-elevation myocardial infarction undergoing primary percutaneous coronary intervention (pPCI) were included in the study. Index of microvascular resistance (IMR) was measured in all patients immediatelly after pPCI before the after administration of Nicorandil. ST segment resolution was monitored before intervention and 60 min after terminating the procedure. Echocardiographic evaluation of myocardial function and transthoracic Doppler derived Coronary flow reserve (CFR) of infarct related artery (IRA) was performed during hospitalization and 3 months later. RESULTS: IMR was significantly lower after administration of Nicorandil (9.9 ± 3.7 vs. 14.1 ± 5.1, p < 0.001). There was significant difference in ST segment elevation before and after primary PCI with administration of Nicorandil (6.9 ± 3.7 mm vs. 1.6 ± 1.6 mm, p < 0.001). Transthoracic Doppler CFR measurement improved after 3 months (2.69 ± 0.38 vs. 2.92 ± 0.54, p = 0.021), as well as WMSI (1.14 ± 0.17 vs. 1.07 ± 0.09, p = 0.004). CONCLUSION: Intracoronary Nicorandil administration after primary PCI significantly decreases IMR, resulting in improved CFR and ventricular function in patients with STEMI undergoing primary PCI.