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Coronary Artery Disease: HELP
Articles by Eleutherios Tsiamis
Based on 3 articles published since 2009
(Why 3 articles?)

Between 2009 and 2019, Eleutherios Tsiamis wrote the following 3 articles about Coronary Artery Disease.
+ Citations + Abstracts
1 Review Matrix metalloproteinases and vulnerable atheromatous plaque. 2012

Toutouzas, Konstantinos / Synetos, Andreas / Nikolaou, Charalampia / Tsiamis, Eleutherios / Tousoulis, Dimitris / Stefanadis, Christodoulos. ·First Department of Cardiology, Hippokration Hospital, Athens, Greece. ktoutouz@otenet.gr ·Curr Top Med Chem · Pubmed #22519447.

ABSTRACT: Atherosclerotic coronary artery disease, the underlying basis for ischemic heart disease, is the leading cause of death and disability in the USA and recent trends indicate that coronary artery disease is also becoming a major public health problem in developing countries [1]. Atherosclerosis is a continuous process that is initiated early in life, which gradually progresses with potentially devastating consequences: atherosclerotic plaque rupture is the most common underlying pathological mechanism creating acute ischemic coronary syndromes [2]. This term refers to the process of disruption of the endothelial surface and the exposure of the underlying prothrombotic vessel wall to circulating platelets and coagulation factors. In order to identify the high-risk plaque we need to recognize its specific morphological and functional characteristics. The morphological characteristics have been identified in several human histopathological and in vivo studies, and include: 1) a large lipid core (≥40% plaque volume) composed of free cholesterol crystals, cholesterol esters, and oxidized lipids impregnated with tissue factor, 2) a thin fibrous cap depleted of smooth muscle cells and collagen, 3) an outward (positive) remodeling, 4) inflammatory cell infiltration of fibrous cap and adventitia (mostly monocyte- macrophages, activated T cells and mast cells), and 5) increased neovascularization. The terms vulnerable, unstable or 'high-risk' are now widely used to describe plaques that exhibit such features, irrespective of whether rupture of the fibrous cap is present [3].

2 Review Differences in drug-eluting stents used in coronary artery disease. 2011

Synetos, Andreas / Toutouzas, Konstantinos / Karanasos, Antonis / Stathogiannis, Konstantinos / Triantafyllou, Georgia / Tsiamis, Eleutherios / Lerakis, Stamatios / Stefanadis, Christodoulos. ·First Department of Cardiology, Hippokration Hospital, University of Athens, Athens, Greece. ·Am J Med Sci · Pubmed #21629039.

ABSTRACT: The introduction of drug-eluting stents (DES) has improved the efficacy of percutaneous coronary intervention by addressing the issue of neointimal proliferation, a pathology contributing to restenosis. First-generation stents eluting sirolimus or paclitaxel were joined by second-generation stents, such as the everolimus- and the zotarolimus-eluting stents, promising increased safety and efficacy. As a result, there is a plethora of drug-eluting stents available, with differences in the stent platform, the polymer coating and the eluted drug, which translate into differences in biological markers of efficacy, such as late loss. However, it remains controversial whether these discrepancies have an impact on clinical markers of safety and efficacy, or if the improved efficacy of DES is a class effect. This article reviews the differences between DES by looking into the biological differences and into trials and registries of DES.

3 Article Effect of gender on the prognostic value of dobutamine stress myocardial contrast echocardiography. 2017

Aggeli, Constantina / Polytarchou, Kali / Felekos, Ioannis / Zisimos, Kostas / Venieri, Erifili / Verveniotis, Athanasios / Varvarousis, Dimitrios / Toutouzas, Kostantinos / Tsiamis, Eleutherios / Tousoulis, Dimitrios. ·1st Cardiology Department, Hippokration Hospital, Athens Medical School, Greece. · 1st Cardiology Department, Hippokration Hospital, Athens Medical School, Greece. Electronic address: kalipolyt@yahoo.gr. ·Hellenic J Cardiol · Pubmed #28442292.

ABSTRACT: BACKGROUND: Dobutamine stress contrast echo (DSCE) has a well-established prognostic value in the context of coronary artery disease (CAD). However, data regarding its prognostic capability separately in men and women are scarce. The aim of the current study was to assess gender-related differences in the prognostic performance of DSCE. METHODS: DSCE was performed in 2645 consecutive patients, who were classified into two groups depending on gender. Follow-up lasted 57.1±10.1 months. End points included all-cause mortality, cardiac death, late revascularization, and hospitalizations. Survival analysis was performed comparing men and women. RESULTS: Of the 2645 patients (59.3±8.7 years), 69.1% were men. DSCE was positive in 23.4% of male patients, while in females, the respective percentage was 14.3%. There was statistically significant difference between the two groups with regard to end point occurrence (11.6% vs. 6.1%, p<0.05). Multivariate analysis revealed that the DSCE response was the strongest predictor of adverse outcomes (Exp(B)=51.9, p<0.05) in both groups. The predictive model including DSCE results along with clinical data performed well without significant differences between males and females (C-index 0.93 vs. 0.87 respectively, p=NS). CONCLUSION: DSCE has a strong prognostic value for patients with known or suspected CAD, regardless of patient gender. This makes DSCE an attractive screening option for women in whom CAD assessment can be challenging.