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Coronary Artery Disease: HELP
Articles by Viktor Voros
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, Viktor Voros wrote the following 3 articles about Coronary Artery Disease.
 
+ Citations + Abstracts
1 Article Comparison of Quantity of Coronary Atherosclerotic Plaques Detected by Computed Tomography Versus Angiography. 2016

Kolossváry, Márton / Szilveszter, Bálint / Édes, István Ferenc / Nardai, Sándor / Voros, Viktor / Hartyánszky, István / Merkely, Béla / Voros, Szilard / Maurovich-Horvat, Pál. ·MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary. · Heart and Vascular Center, Semmelweis University, Budapest, Hungary. · Global Genomics Group, Atlanta, Georgia; Department of Psychiatry, University of Pecs, Pecs, Hungary. · Global Genomics Group, Atlanta, Georgia. · MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary. Electronic address: p.maurovich.horvat@mail.harvard.edu. ·Am J Cardiol · Pubmed #27134058.

ABSTRACT: Numerous clinical studies using coronary computed tomography angiography (CTA) and conventional invasive coronary angiography (ICA) confirmed the strong relation between atherosclerotic disease burden and risk of adverse events. Few studies have compared coronary CTA and ICA regarding semiquantitative plaque burden measurements, reproducibility, and cardiovascular risk assessment. We enrolled 71 consecutive patients (mean age 62 ± 9 years, 37% women) from the Genetic Loci and the Burden of Atherosclerotic Lesions study (NCT01738828), who underwent 256-slice multidetector row coronary CTA and ICA at a single site. On average, 42 ± 32 days passed between the 2 examinations. A total of 1,016 coronary segments were imaged by both CTA and ICA according the 18-segment Society of Cardiovascular Computed Tomography classification. We excluded 16 segments treated with coronary stents. Overall, 1,000 segments were evaluated for the presence of stenosis severity (<25%: minimal, 25% to 49%: mild, 50% to 70%: moderate, 70% to 99%: severe, 100%: occlusion). We calculated the segment involvement score (SIS) and segment stenosis score. Patients were classified into 4 groups: extensive obstructive (SIS >4 and ≥50% stenosis), extensive nonobstructive (SIS >4 and <50% stenosis), nonextensive obstructive (SIS ≤4 and ≥50% stenosis), or nonextensive nonobstructive (SIS ≤4 and <50% stenosis). CTA detected coronary artery plaques in 49%, whereas ICA showed coronary plaques in 24% of the analyzed 1,000 segments (p <0.001). CTA detected atherosclerotic plaque in 35% of coronary segments where ICA was negative, whereas ICA detected plaque only in 3% of segments where CTA was negative. CTA-based segment scores were significantly greater, SIS: 6.9 ± 3.0 versus 3.3 ± 2.0, segment stenosis score: 16.4 ± 8.8 versus 9.4 ± 6.8 (p <0.001 for both). In conclusion, coronary CTA detected approximately twice as many coronary segments with plaque compared to ICA, which resulted in 52% of the patients being assigned to a greater risk category.

2 Article Rationale, Design, and Methodological Aspects of the BUDAPEST-GLOBAL Study (Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions). 2015

Maurovich-Horvat, Pál / Tárnoki, Dávid L / Tárnoki, Ádám D / Horváth, Tamás / Jermendy, Ádám L / Kolossváry, Márton / Szilveszter, Bálint / Voros, Viktor / Kovács, Attila / Molnár, Andrea Á / Littvay, Levente / Lamb, Hildo J / Voros, Szilard / Jermendy, György / Merkely, Béla. ·MTA-SE Cardiovascular Imaging Research Group, Heart and Vascular Center, Semmelweis University, Budapest, Hungary. · Department of Radiology and Oncotherapy, Semmelweis University, Budapest, Hungary. · Department of Hydrodynamic Systems, Budapest University of Technology and Economics, Budapest, Hungary. · Scientific Affairs, Global Institute for Research, LLC, Richmond, Virginia. · Department of Cardiology, Military Hospital, Budapest, Hungary. · Department of Political Science, Central European University, Budapest, Hungary. · Department of Radiology, Leiden University Medical Center, Leiden, The Netherlands. · Department of Internal Medicine, Bajcsy-Zsilinszky Hospital, Budapest, Hungary. ·Clin Cardiol · Pubmed #26492817.

ABSTRACT: The heritability of coronary atherosclerotic plaque burden, coronary geometry, and phenotypes associated with increased cardiometabolic risk are largely unknown. The primary aim of the Burden of Atherosclerotic Plaques Study in Twins-Genetic Loci and the Burden of Atherosclerotic Lesions (BUDAPEST-GLOBAL) study is to evaluate the influence of genetic and environmental factors on the burden of coronary artery disease. By design this is a prospective, single-center, classical twin study. In total, 202 twins (61 monozygotic pairs, 40 dizygotic same-sex pairs) were enrolled from the Hungarian Twin Registry database. All twins underwent non-contrast-enhanced computed tomography (CT) for the detection and quantification of coronary artery calcium and for the measurement of epicardial fat volumes. In addition, a single non-contrast-enhanced image slice was acquired at the level of L3-L4 to assess abdominal fat distribution. Coronary CT angiography was used for the detection and quantification of plaque, stenosis, and overall coronary artery disease burden. For the primary analysis, we will assess the presence and volume of atherosclerotic plaques. Furthermore, the 3-dimensional coronary geometry will be assessed based on the coronary CT angiography datasets. Additional phenotypic analyses will include per-patient epicardial and abdominal fat quantity measurements. Measurements obtained from monozygotic and dizygotic twin pairs will be compared to evaluate the genetic or environmental effects of the given phenotype. The BUDAPEST-GLOBAL study provides a unique framework to shed some light on the genetic and environmental influences of cardiometabolic disorders.

3 Article Precision phenotyping, panomics, and system-level bioinformatics to delineate complex biologies of atherosclerosis: rationale and design of the "Genetic Loci and the Burden of Atherosclerotic Lesions" study. 2014

Voros, Szilard / Maurovich-Horvat, Pal / Marvasty, Idean B / Bansal, Aruna T / Barnes, Michael R / Vazquez, Gustavo / Murray, Sarah S / Voros, Viktor / Merkely, Bela / Brown, Bradley O / Warnick, G Russell. ·Global Genomics Group, LLC, 737 N. 5th Street, Richmond, VA 23219, USA. Electronic address: szilardvorosmd@gmail.com. · Semmelweis University, Budapest, Hungary. · Global Genomics Group, LLC, 737 N. 5th Street, Richmond, VA 23219, USA. · Acclarogen, Ltd. Cambridge, UK. · Queen Mary University, London, UK. · Global Institute for Research, LLC, Richmond, VA, USA. · University of California at San Diego, San Diego, CA, USA. · Health Diagnostic Laboratory, LLC, Richmond, VA, USA. ·J Cardiovasc Comput Tomogr · Pubmed #25439791.

ABSTRACT: BACKGROUND: Complex biological networks of atherosclerosis are largely unknown. OBJECTIVE: The main objective of the Genetic Loci and the Burden of Atherosclerotic Lesions study is to assemble comprehensive biological networks of atherosclerosis using advanced cardiovascular imaging for phenotyping, a panomic approach to identify underlying genomic, proteomic, metabolomic, and lipidomic underpinnings, analyzed by systems biology-driven bioinformatics. METHODS: By design, this is a hypothesis-free unbiased discovery study collecting a large number of biologically related factors to examine biological associations between genomic, proteomic, metabolomic, lipidomic, and phenotypic factors of atherosclerosis. The Genetic Loci and the Burden of Atherosclerotic Lesions study (NCT01738828) is a prospective, multicenter, international observational study of atherosclerotic coronary artery disease. Approximately 7500 patients are enrolled and undergo non-contrast-enhanced coronary calcium scanning by CT for the detection and quantification of coronary artery calcium, as well as coronary artery CT angiography for the detection and quantification of plaque, stenosis, and overall coronary artery disease burden. In addition, patients undergo whole genome sequencing, DNA methylation, whole blood-based transcriptome sequencing, unbiased proteomics based on mass spectrometry, as well as metabolomics and lipidomics on a mass spectrometry platform. The study is analyzed in 3 subsequent phases, and each phase consists of a discovery cohort and an independent validation cohort. For the primary analysis, the primary phenotype will be the presence of any atherosclerotic plaque, as detected by cardiac CT. Additional phenotypic analyses will include per patient maximal luminal stenosis defined as 50% and 70% diameter stenosis. Single-omic and multi-omic associations will be examined for each phenotype; putative biomarkers will be assessed for association, calibration, discrimination, and reclassification.