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Coronary Artery Disease: HELP
Articles by Yinge Wu
Based on 11 articles published since 2009
(Why 11 articles?)
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Between 2009 and 2019, Ying Wu wrote the following 11 articles about Coronary Artery Disease.
 
+ Citations + Abstracts
1 Clinical Trial Elevated survivin expression in peripheral blood mononuclear cells is central to collateral formation in coronary chronic total occlusion. 2015

Xu, Yiguan / Tan, Xuerui / Wang, Dongming / Wang, Wei / Li, Yuguang / Wu, Min / Chen, Songming / Wu, Yinge / Tan, Chunjiang. ·Department of Cardiology, The First Affiliated Hospital of Shantou University Medical College, Shantou, Guangdong 515041, P.R. China. ·Int J Mol Med · Pubmed #25816072.

ABSTRACT: Survivin is essential to angiogenesis and revascularization, but its role in coronary collateral formation remains unclear. The role of survivin in peripheral blood mononuclear cells (PBMCs) of coronary chronic total occlusion (CTO) patients was investigated. Coronary CTO patients (n=46; mean age 60.1±8.5, male 54.3%) (CTO group) and normal control patients (n=18; mean age 58.0±10.0, male 55.6%) underwent angiographic collateral vessel grading by Rentrop classification (C0 - C3) and provided peripheral blood between June 2006 and February 2007. Rat hind limb ischemia models were constructed using four equal groups of Sprague-Dawley rats (n=36): normal control, sham operation, operation and granulocyte macrophage colony-stimulating factor (GM-CSF). PBMC numbers and characteristics, collateral vessels, survivin, CD4, CD8, CD44, vascular endothelial growth factor (VEGF) and intercellular adhesion molecule-1 (ICAM-1) expression were determined using RT-PCR, flow cytometry, immunocytochemistry and western blot analysis. PBMC survivin mRNA and protein expression levels were higher in patients with good collateral circulation (C2 + C3) than in patients with no collateral flow (C0) (all P<0.05). Survivin single-positive and survivin and CD8, VEGF and ICAM-1 double-positive percentages were elevated in patients with good collateral circulation compared to those with normal and no collateral flow (all P<0.05), consistent with the rat model results, wherein higher survivin levels produced significantly larger and more visible collateral vessels. In conclusion, elevated survivin expression in PBMCs, particularly survivin and CD8, VEGF, and ICAM-1 double-positive PBMCs, may be crucial for good collateral formation in patients with coronary CTO, as confirmed by assessment of a rat model.

2 Article Strong association between the interleukin-8-251A/T polymorphism and coronary artery disease risk. 2019

Wu, Ying / Wang, Wei / Li, Xiao-Yan / Qian, Ling-Ling / Dang, Shi-Peng / Tang, Xu / Chen, Heng-Jian / Wang, Ru-Xing. ·Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University. · Wuxi Center for Disease Control and Prevention, Wuxi, Jiangsu, China. ·Medicine (Baltimore) · Pubmed #30855465.

ABSTRACT: Several reports have suggested a possible association between the interleukin (IL)-8-251A/T single-nucleotide polymorphism (SNP) and the susceptibility to coronary artery disease (CAD). Due to inconclusive results of the studies so far, we conducted a meta-analysis to systematically summarize the studies on the association between this SNP and CAD risk. A systematic literature search identified 9 case-control studies (3752 cases and 4219 controls) on the IL-8-251A/T polymorphism. We observed a significant association between different genetic forms of -251A/T SNP and CAD risk, like the allele model (A vs T: odds ratio [OR] 1.14, 95% confidence interval [CI] 1.02-1.27, P = .02), dominant model (AA + AT vs TT: OR 1.20, 95% CI 1.01-1.43, P = .042), recessive model (AA vs AT + TT: OR 1.15, 95% CI 1.03-1.27, P = .01), and homozygous model (AA vs TT: OR 1.26, 95% CI 1.01-1.56, P = .037), whereas the heterozygote model did not show any significant association (AT vs TT: OR 1.16, 95% CI 0.98-1.38, P = .091). Furthermore, significant heterogeneity was observed among studies in terms of all genetic models, except the recessive model. Analysis of the ethnic subgroups revealed a significantly higher risk of CAD in the East Asian population carrying this SNP, and the heterogeneity among the studies regarding the East Asian population was decreased after subgroup analysis. The results of this meta-analysis suggest that the IL-8-251A/T SNP may increase the risk of CAD, especially in people of East Asian ethnicity. Further large-scale, multicenter epidemiological studies are warranted to validate this finding.

3 Article A Modified Supine Position Facilitates Bladder Function in Patients Undergoing Percutaneous Coronary Intervention: A Randomized Controlled Clinical Trial. 2018

Liu, Yisi / Zhang, Ying / Wu, Ying / Elliott, Malcolm. ·Yisi Liu, MSc, RN School of Nursing, Capital Medical University, Beijing, China. Ying Zhang, MSc, RN Beijing Anzhen Hospital, Capital Medical University, China. Ying Wu, PhD, RN School of Nursing, Capital Medical University, Beijing, China. Malcolm Elliott, PhD, RN School of Nursing & Midwifery, Monash University, Melbourne, Australia. ·J Cardiovasc Nurs · Pubmed #28723835.

ABSTRACT: BACKGROUND: Percutaneous coronary intervention (PCI) is currently the most common intervention for cardiovascular disease. Standard care after PCI typically involves a period of bed rest in the supine position, but this position creates voiding difficulties. OBJECTIVE: This study aimed to determine whether a modified supine position could facilitate bladder emptying after PCI. METHOD: A randomized controlled trial involving 300 patients was conducted. Patients in the intervention group were nursed in the supine position with the bed tilted 20° upright and with a pillow between their feet and the end of the bed. Patients in the control group received standard care, which was supine positioning. RESULTS: One hundred fifty patients were allocated to the intervention group (100 men, 50 women), and 150 were allocated to the control group (103 men, 47 women). Baseline data did not differ between the 2 groups. Patients in the intervention group had significantly better bladder function as evidenced by a shorter time to the first void (5 vs 15 minutes) and fewer patients requiring voiding assistance (8.6% vs 35.3%). Residual urinary volumes were also much lower in the intervention group (88.71 vs 248.22 mL, P < .001). CONCLUSIONS: This study demonstrates that a modified supine position can reduce the incidence of impaired micturition and the preservation of normal bladder function after PCI.

4 Article Exome chip meta-analysis identifies novel loci and East Asian-specific coding variants that contribute to lipid levels and coronary artery disease. 2017

Lu, Xiangfeng / Peloso, Gina M / Liu, Dajiang J / Wu, Ying / Zhang, He / Zhou, Wei / Li, Jun / Tang, Clara Sze-Man / Dorajoo, Rajkumar / Li, Huaixing / Long, Jirong / Guo, Xiuqing / Xu, Ming / Spracklen, Cassandra N / Chen, Yang / Liu, Xuezhen / Zhang, Yan / Khor, Chiea Chuen / Liu, Jianjun / Sun, Liang / Wang, Laiyuan / Gao, Yu-Tang / Hu, Yao / Yu, Kuai / Wang, Yiqin / Cheung, Chloe Yu Yan / Wang, Feijie / Huang, Jianfeng / Fan, Qiao / Cai, Qiuyin / Chen, Shufeng / Shi, Jinxiu / Yang, Xueli / Zhao, Wanting / Sheu, Wayne H-H / Cherny, Stacey Shawn / He, Meian / Feranil, Alan B / Adair, Linda S / Gordon-Larsen, Penny / Du, Shufa / Varma, Rohit / Chen, Yii-Der Ida / Shu, Xiao-Ou / Lam, Karen Siu Ling / Wong, Tien Yin / Ganesh, Santhi K / Mo, Zengnan / Hveem, Kristian / Fritsche, Lars G / Nielsen, Jonas Bille / Tse, Hung-Fat / Huo, Yong / Cheng, Ching-Yu / Chen, Y Eugene / Zheng, Wei / Tai, E Shyong / Gao, Wei / Lin, Xu / Huang, Wei / Abecasis, Goncalo / Anonymous2270925 / Kathiresan, Sekar / Mohlke, Karen L / Wu, Tangchun / Sham, Pak Chung / Gu, Dongfeng / Willer, Cristen J. ·Department of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China. · Division of Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. · Department of Human Genetics, University of Michigan, Ann Arbor, Michigan, USA. · Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. · Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA. · Department of Public Health Sciences, Institute of Personalized Medicine, Penn State University, University Park, Pennsylvania, USA. · Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA. · Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan, USA. · MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science & Technology, Wuhan, Hubei, China. · Department of Surgery, Li KaShing Faculty of Medicine, The University of Hong Kong, Hong Kong, China; Dr. Li Dak-Sum Research Centre, The University of Hong Kong-Karolinska Institutet Collaboration in Regenerative Medicine, Hong Kong, China. · Genome Institute of Singapore, Agency for Science, Technology and Research, Singapore, Singapore. · Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and University of the Chinese Academy of Sciences, Shanghai, China. · Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University School of Medicine, Nashville, Tennessee, USA. · Institute for Translational Genomics and Population Sciences, LABioMed at Harbor-UCLA Medical Center, Los Angeles, California, USA. · Department of Cardiology, Institute of Vascular Medicine, Peking University Third Hospital, Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Beijing, China. · Center for Genomic and Personalized Medicine, Medical Scientific Research Center and Department of Occupational Health and Environmental Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi, China. · Department of Cardiology, Peking University First Hospital, Beijing, China. · Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore. · Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. · Department of Epidemiology, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. · Department of Medicine, the University of Hong Kong, Hong Kong, China. · Community Health Center, The 3rd Affiliated Hospital of Shenzhen University, Shenzhen, China. · Duke-National University of Singapore Graduate Medical School, Singapore, Singapore. · Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China. · Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. · Department of Psychiatry, the University of Hong Kong, Hong Kong, China. · Centre for Genomic Sciences, Li KaShing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. · State Key Laboratory of Brain and Cognitive Sciences, The University of Hong Kong, Hong Kong, China. · USC-Office of Population Studies Foundation, University of San Carlos, Cebu City, Philippines. · Department of Anthropology, Sociology, and History, University of San Carlos, Cebu City, Philippines. · Department of Nutrition, Gillings School of Global Public Health, University of North Carolina, Chapel Hill, North Carolina, USA. · Carolina Population Center, University of North Carolina, Chapel Hill, North Carolina, USA. · USC Eye Institute, Department of Ophthalmology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA. · Research Centre of Heart, Brain, Hormone and Healthy Aging, Li KaShing Faculty of Medicine, The University of Hong Kong, Hong Kong, China. · State Key Laboratory of Pharmaceutical Biotechnology, The University of Hong Kong, Hong Kong, China. · Saw Swee Hock School of Public Health, National University Health System, National University of Singapore, Singapore, Singapore. · Department of Ophthalmology, National University of Singapore, Singapore, Singapore. · HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway. · K.G. Jebsen Center for Genetic Epidemiology, Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway. · Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, Levanger, Norway. · Department of Biostatistics, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA. · Hong Kong-Guangdong Joint Laboratory on Stem Cell and Regenerative Medicine, the University of Hong Kong, Hong Kong, China. · Ophthalmology and Visual Sciences Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. · Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, National University Health System, Singapore, Singapore. · Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts, USA. ·Nat Genet · Pubmed #29083407.

ABSTRACT: Most genome-wide association studies have been of European individuals, even though most genetic variation in humans is seen only in non-European samples. To search for novel loci associated with blood lipid levels and clarify the mechanism of action at previously identified lipid loci, we used an exome array to examine protein-coding genetic variants in 47,532 East Asian individuals. We identified 255 variants at 41 loci that reached chip-wide significance, including 3 novel loci and 14 East Asian-specific coding variant associations. After a meta-analysis including >300,000 European samples, we identified an additional nine novel loci. Sixteen genes were identified by protein-altering variants in both East Asians and Europeans, and thus are likely to be functional genes. Our data demonstrate that most of the low-frequency or rare coding variants associated with lipids are population specific, and that examining genomic data across diverse ancestries may facilitate the identification of functional genes at associated loci.

5 Article Regulation of Coronary Arterial Large Conductance Ca2+-Activated K+ Channel Protein Expression and Function by n-3 Polyunsaturated Fatty Acids in Diabetic Rats. 2017

Tang, Xu / Qian, Ling-Ling / Wang, Ru-Xing / Yao, Yong / Dang, Shi-Peng / Wu, Ying / Wang, Wen / Ji, Yuan / Sun, Man-Qing / Xia, Da-Yun / Liu, Xiao-Yu / Zhang, Dai-Min / Chai, Qiang / Lu, Tong. ·Department of Cardiology, Wuxi People's Hospital Affiliated to Nanjing Medical University, Wuxi, China. ·J Vasc Res · Pubmed #29040972.

ABSTRACT: AIM: The objective of this study was to examine the effects of n-3 polyunsaturated fatty acids (n-3 PUFAs) on coronary arterial large conductance Ca2+-activated K+ (BK) channel function in coronary smooth muscle cells (SMCs) of streptozotocin-induced diabetic rats. METHODS: The effects of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) on coronary BK channel open probabilities were determined using the patch clamp technique. The mRNA and protein expressions of BK channel subunits were measured using qRT-PCR and Western blots. The coronary artery tension and coronary SMC Ca2+ concentrations were measured using a myograph system and fluorescence Ca2+ indicator. RESULTS: Compared to nondiabetic control rats, the BK channel function was impaired with a reduced response to EPA and DHA in freshly isolated SMCs of diabetic rats. Oral administration of n-3 PUFAs had no effects on protein expressions of BK channel subunits in nondiabetic rats, but significantly enhanced those of BK-β1 in diabetic rats without altering BK-α protein levels. Moreover, coronary ring tension induced by iberiotoxin (a specific BK channel blocker) was increased and cytosolic Ca2+ concentrations in coronary SMCs were decreased in diabetic rats, but no changes were found in nondiabetic rats. CONCLUSIONS: n-3 PUFAs protect the coronary BK channel function and coronary vasoreactivity in diabetic rats as a result of not only increasing BK-β1 protein expressions, but also decreasing coronary artery tension and coronary smooth muscle cytosolic Ca2+ concentrations.

6 Article MicroRNA-32 promotes calcification in vascular smooth muscle cells: Implications as a novel marker for coronary artery calcification. 2017

Liu, Jianghua / Xiao, Xinhua / Shen, Yingying / Chen, Ling / Xu, Canxin / Zhao, Heng / Wu, Ying / Zhang, Qinghai / Zhong, Jing / Tang, Zhenwang / Liu, Changhui / Zhao, Qiang / Zheng, Yi / Cao, Renxian / Zu, Xuyu. ·Institute of Clinical Medicine, the First Affiliated Hospital of University of South China, Hengyang, People's Republic of China (PRC). · Department of Metabolism and Endocrinology, the First Affiliated Hospital of University of South China, Hengyang, PRC. · Department of Pathology and Immunology, University of Washington School of Medicine, St. Louis, Missouri, United States of America. · Department of Cardiovascular Medicine, the First Affiliated Hospital of University of South China, Hengyang, PRC. ·PLoS One · Pubmed #28319142.

ABSTRACT: Cardiovascular calcification is one of the most severe outcomes associated with cardiovascular disease and often results in significant morbidity and mortality. Previous reports indicated that epigenomic regulation of microRNAs (miRNAs) might play important roles in vascular smooth muscle cell (VSMC) calcification. Here, we identified potential key miRNAs involved in vascular calcification in vivo and investigated the role of miR-32-5p (miR-32). According to microarray analysis, we observed increased expression of miR-125b, miR-30a, and miR-32 and decreased expression of miR-29a, miR-210, and miR-320 during the progression of vascularcalcification. Additionally, gain- and loss-of-function studies of miR-32 confirmed promotion of VSMC calcification in mice through the enhanced expression of bonemorphogenetic protein-2, runt-related transcription factor-2(RUNX2), osteopontin, and the bone-specific phosphoprotein matrix GLA protein in vitro. Moreover, miR-32 modulated vascularcalcification progression by activating phosphoinositide 3-kinase (PI3K)signaling and increasing RUNX2 expression and phosphorylation by targeting the 3'-untranslated region of phosphatase and tensin homolog Mrna (PTEN) in mouse VSMCs. Furthermore, we detected higher miR-32 levels in plasmafrom patients with coronary artery disease with coronary artery calcification (CAC) as compared with levels observed in non-CAC patients (P = 0.016), further confirming miR-32 as a critical modulator and potential diagnostic marker for CAC.

7 Article Genome-wide associations for birth weight and correlations with adult disease. 2016

Horikoshi, Momoko / Beaumont, Robin N / Day, Felix R / Warrington, Nicole M / Kooijman, Marjolein N / Fernandez-Tajes, Juan / Feenstra, Bjarke / van Zuydam, Natalie R / Gaulton, Kyle J / Grarup, Niels / Bradfield, Jonathan P / Strachan, David P / Li-Gao, Ruifang / Ahluwalia, Tarunveer S / Kreiner, Eskil / Rueedi, Rico / Lyytikäinen, Leo-Pekka / Cousminer, Diana L / Wu, Ying / Thiering, Elisabeth / Wang, Carol A / Have, Christian T / Hottenga, Jouke-Jan / Vilor-Tejedor, Natalia / Joshi, Peter K / Boh, Eileen Tai Hui / Ntalla, Ioanna / Pitkänen, Niina / Mahajan, Anubha / van Leeuwen, Elisabeth M / Joro, Raimo / Lagou, Vasiliki / Nodzenski, Michael / Diver, Louise A / Zondervan, Krina T / Bustamante, Mariona / Marques-Vidal, Pedro / Mercader, Josep M / Bennett, Amanda J / Rahmioglu, Nilufer / Nyholt, Dale R / Ma, Ronald Ching Wan / Tam, Claudia Ha Ting / Tam, Wing Hung / Anonymous24350882 / Ganesh, Santhi K / van Rooij, Frank Ja / Jones, Samuel E / Loh, Po-Ru / Ruth, Katherine S / Tuke, Marcus A / Tyrrell, Jessica / Wood, Andrew R / Yaghootkar, Hanieh / Scholtens, Denise M / Paternoster, Lavinia / Prokopenko, Inga / Kovacs, Peter / Atalay, Mustafa / Willems, Sara M / Panoutsopoulou, Kalliope / Wang, Xu / Carstensen, Lisbeth / Geller, Frank / Schraut, Katharina E / Murcia, Mario / van Beijsterveldt, Catharina Em / Willemsen, Gonneke / Appel, Emil V R / Fonvig, Cilius E / Trier, Caecilie / Tiesler, Carla Mt / Standl, Marie / Kutalik, Zoltán / Bonas-Guarch, Sílvia / Hougaard, David M / Sánchez, Friman / Torrents, David / Waage, Johannes / Hollegaard, Mads V / de Haan, Hugoline G / Rosendaal, Frits R / Medina-Gomez, Carolina / Ring, Susan M / Hemani, Gibran / McMahon, George / Robertson, Neil R / Groves, Christopher J / Langenberg, Claudia / Luan, Jian'an / Scott, Robert A / Zhao, Jing Hua / Mentch, Frank D / MacKenzie, Scott M / Reynolds, Rebecca M / Anonymous24360882 / Lowe, William L / Tönjes, Anke / Stumvoll, Michael / Lindi, Virpi / Lakka, Timo A / van Duijn, Cornelia M / Kiess, Wieland / Körner, Antje / Sørensen, Thorkild Ia / Niinikoski, Harri / Pahkala, Katja / Raitakari, Olli T / Zeggini, Eleftheria / Dedoussis, George V / Teo, Yik-Ying / Saw, Seang-Mei / Melbye, Mads / Campbell, Harry / Wilson, James F / Vrijheid, Martine / de Geus, Eco Jcn / Boomsma, Dorret I / Kadarmideen, Haja N / Holm, Jens-Christian / Hansen, Torben / Sebert, Sylvain / Hattersley, Andrew T / Beilin, Lawrence J / Newnham, John P / Pennell, Craig E / Heinrich, Joachim / Adair, Linda S / Borja, Judith B / Mohlke, Karen L / Eriksson, Johan G / Widén, Elisabeth E / Kähönen, Mika / Viikari, Jorma S / Lehtimäki, Terho / Vollenweider, Peter / Bønnelykke, Klaus / Bisgaard, Hans / Mook-Kanamori, Dennis O / Hofman, Albert / Rivadeneira, Fernando / Uitterlinden, André G / Pisinger, Charlotta / Pedersen, Oluf / Power, Christine / Hyppönen, Elina / Wareham, Nicholas J / Hakonarson, Hakon / Davies, Eleanor / Walker, Brian R / Jaddoe, Vincent Wv / Jarvelin, Marjo-Riitta / Grant, Struan Fa / Vaag, Allan A / Lawlor, Debbie A / Frayling, Timothy M / Davey Smith, George / Morris, Andrew P / Ong, Ken K / Felix, Janine F / Timpson, Nicholas J / Perry, John Rb / Evans, David M / McCarthy, Mark I / Freathy, Rachel M. ·Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. · Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. · Institute of Biomedical and Clinical Science, University of Exeter Medical School, Royal Devon and Exeter Hospital, Exeter, UK. · MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, UK. · The University of Queensland Diamantina Institute, Translational Research Institute, Brisbane, Australia. · School of Women's and Infants' Health, The University of Western Australia, Perth, Australia. · The Generation R Study Group, Erasmus MC, University Medical Center Rotterdam, the Netherlands. · Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, the Netherlands. · Department of Pediatrics, Erasmus MC, University Medical Center Rotterdam, the Netherlands. · Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark. · Department of Pediatrics, University of California San Diego, La Jolla, California, USA. · The Novo Nordisk Foundation Center for Basic Metabolic Research, Section of Metabolic Genetics, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. · Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. · Population Health Research Institute, St George's University of London, London, Cranmer Terrace, UK. · Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, the Netherlands. · COPSAC, Copenhagen Prospective Studies on Asthma in Childhood, Herlev and Gentofte Hospital, University of Copenhagen, Copenhagen, Denmark. · Steno Diabetes Center, Gentofte, Denmark. · Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. · Swiss Institute of Bioinformatics, Lausanne, Switzerland. · Department of Clinical Chemistry, Fimlab Laboratories, Tampere, Finland. · Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere, Finland. · Institute for Molecular Medicine, Finland (FIMM), University of Helsinki, Helsinki, Finland. · Division of Human Genetics, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. · Department of Genetics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. · Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. · Institute of Epidemiology I, Helmholtz Zentrum München- German Research Center for Environmental Health, Neuherberg, Germany. · Division of Metabolic and Nutritional Medicine, Dr. von Hauner Children's Hospital, University of Munich Medical Center, Munich, Germany. · Netherlands Twin Register, Department of Biological Psychology, VU University, Amsterdam, the Netherlands. · ISGlobal, Centre for Research in Environmental Epidemiology (CREAL), Barcelona, Spain. · Universitat Pompeu Fabra (UPF), Barcelona, Spain. · CIBER de Epidemiología y Salud Pública (CIBERESP), Spain. · Usher Institute for Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, UK. · Saw Swee Hock School of Public Health, National University of Singapore, National University Health System, Singapore, Singapore. · William Harvey Research Institute, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. · Department of Nutrition and Dietetics, School of Health Science and Education, Harokopio University, Athens, Greece. · Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. · Institute of Biomedicine, Physiology, University of Eastern Finland, Kuopio, Finland. · KUL - University of Leuven, Department of Neurosciences, Leuven, Belgium. · Translational Immunology Laboratory, VIB, Leuven, Belgium. · Department of Preventive Medicine, Division of Biostatistics, Feinberg School of Medicine, Northwestern University, Chicago, USA. · Institute of Cardiovascular & Medical Sciences, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, UK. · Endometriosis CaRe Centre, Nuffield Department of Obstetrics & Gynaecology, University of Oxford, Oxford, UK. · Center for Genomic Regulation (CRG), Barcelona, Spain. · Department of Internal Medicine, Internal Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland. · Joint BSC-CRG-IRB Research Program in Computational Biology, Barcelona Supercomputing Center, Barcelona, Spain. · Institute of Health and Biomedical Innovation, Queensland University of Technology, Queensland, Australia. · Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China. · Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China. · Hong Kong Institute of Diabetes and Obesity, The Chinese University of Hong Kong, Hong Kong, China. · Department of Obstetrics and Gynaecology, The Chinese University of Hong Kong, Hong Kong, Hong Kong, China. · Cardiovascular Medicine, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan, USA. · Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA. · Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA. · European Centre for Environment and Human Health, University of Exeter, Truro, UK. · Medical Research Council Integrative Epidemiology Unit at the University of Bristol, Bristol, UK. · School of Social and Community Medicine, University of Bristol, Bristol, UK. · Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK. · IFB Adiposity Diseases, University of Leipzig, Leipzig, Germany. · Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire, UK. · FISABIO-Universitat Jaume I-Universitat de València, Joint Research Unit of Epidemiology and Environmental Health, Valencia, Spain. · The Children's Obesity Clinic, Department of Pediatrics, Copenhagen University Hospital Holbæk, Holbæk, Denmark. · Institute of Social and Preventive Medicine, Lausanne University Hospital (CHUV), Lausanne, Switzerland. · Danish Center for Neonatal Screening, Statens Serum Institute, Copenhagen, Denmark. · Department for Congenital Disorders, Statens Serum Institute, Copenhagen, Denmark. · Computer Sciences Department, Barcelona Supercomputing Center, Barcelona, Spain. · Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain. · Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, the Netherlands. · BHF Centre for Cardiovascular Science, University of Edinburgh, Queen's Medical Research Institute, Edinburgh, Scotland, UK. · Department of Medicine, Division of Endocrinology, Metabolism, and Molecular Medicine, Feinberg School of Medicine, Northwestern University, Chicago, USA. · Medical Department, University of Leipzig, Leipzig, Germany. · Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. · Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. · Pediatric Research Center, Department of Women´s & Child Health, University of Leipzig, Leipzig, Germany. · Novo Nordisk Foundation Center for Basic Metabolic Research and Department of Public Health, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. · Institute of Preventive Medicine, Bispebjerg and Frederiksberg Hospital, The Capital Region, Copenhagen, Denmark. · Department of Pediatrics, Turku University Hospital, Turku, Finland. · Department of Physiology, University of Turku, Turku, Finland. · Paavo Nurmi Centre, Sports and Exercise Medicine Unit, Department of Physical Activity and Health, Turku, Finland. · Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. · Department of Statistics and Applied Probability, National University of Singapore, Singapore, Singapore. · Life Sciences Institute, National University of Singapore, Singapore, Singapore. · Singapore Eye Research Institute, Singapore, Singapore. · Department of Clinical Medicine, Copenhagen University, Copenhagen, Denmark. · Department of Medicine, Stanford School of Medicine, Stanford, California, USA. · MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, Scotland, UK. · EMGO Institute for Health and Care Research, VU University and VU University Medical Center, Amsterdam, the Netherlands. · Department of Large Animal Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark. · Center for Life Course Health Research, Faculty of Medicine, University of Oulu, Oulu, Finland. · Biocenter Oulu, University of Oulu, Finland. · School of Medicine and Pharmacology, Royal Perth Hospital Unit, The University of Western Australia, Perth, Australia. · Institute and Outpatient Clinic for Occupational, Social and Environmental Medicine, Inner City Clinic, University Hospital Munich, Ludwig Maximilian University of Munich, Munich, Germany. · Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA. · USC-Office of Population Studies Foundation, Inc., University of San Carlos, Cebu City, Philippines. · Department of Nutrition and Dietetics, University of San Carlos, Cebu City, Philippines. · National Institute for Health and Welfare, Helsinki, Finland. · Department of General Practice and Primary Health Care, University of Helsinki and Helsinki University Hospital, Helsinki, Finland. · Folkhälsan Research Center, Helsinki, Finland. · Department of Clinical Physiology, Tampere University Hopital, Tampere, Finland. · Department of Clinical Physiology, University of Tampere School of Medicine, Tampere, Finland. · Division of Medicine, Turku University Hospital, Turku, Finland. · Department of Medicine, University of Turku, Turku, Finland. · Department of Public Health and Primary Care, Leiden University Medical Center, Leiden, the Netherlands. · Epidemiology Section, BESC Department, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia. · Research Center for Prevention and Health Capital Region, Center for Sundhed, Rigshospitalet - Glostrup, Copenhagen University, Glostrup, Denmark. · Population, Policy and Practice, UCL Institute of Child Health, University College London, London, UK. · Centre for Population Health Research, School of Health Sciences, and Sansom Institute, University of South Australia, Adelaide, Australia. · South Australian Health and Medical Research Institute, Adelaide, Australia. · Department of Pediatrics, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA. · Department of Epidemiology and Biostatistics, MRC-PHE Centre for Environment & Health, School of Public Health, Imperial College London, London, UK. · Unit of Primary Care, Oulu University Hospital, Oulu, Finland. · Division of Endocrinology, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA. · Department of Endocrinology, Rigshospitalet, Copenhagen, Denmark. · Department of Biostatistics, University of Liverpool, Liverpool, UK. · Estonian Genome Center, University of Tartu, Tartu, Estonia. · Department of Paediatrics, University of Cambridge, Cambridge, UK. · Oxford National Institute for Health Research (NIHR) Biomedical Research Centre, Churchill Hospital, Oxford, UK. ·Nature · Pubmed #27680694.

ABSTRACT: Birth weight (BW) has been shown to be influenced by both fetal and maternal factors and in observational studies is reproducibly associated with future risk of adult metabolic diseases including type 2 diabetes (T2D) and cardiovascular disease. These life-course associations have often been attributed to the impact of an adverse early life environment. Here, we performed a multi-ancestry genome-wide association study (GWAS) meta-analysis of BW in 153,781 individuals, identifying 60 loci where fetal genotype was associated with BW (P < 5 × 10

8 Article Discovery and refinement of loci associated with lipid levels. 2013

Willer, Cristen J / Schmidt, Ellen M / Sengupta, Sebanti / Peloso, Gina M / Gustafsson, Stefan / Kanoni, Stavroula / Ganna, Andrea / Chen, Jin / Buchkovich, Martin L / Mora, Samia / Beckmann, Jacques S / Bragg-Gresham, Jennifer L / Chang, Hsing-Yi / Demirkan, Ayşe / Den Hertog, Heleen M / Do, Ron / Donnelly, Louise A / Ehret, Georg B / Esko, Tõnu / Feitosa, Mary F / Ferreira, Teresa / Fischer, Krista / Fontanillas, Pierre / Fraser, Ross M / Freitag, Daniel F / Gurdasani, Deepti / Heikkilä, Kauko / Hyppönen, Elina / Isaacs, Aaron / Jackson, Anne U / Johansson, Åsa / Johnson, Toby / Kaakinen, Marika / Kettunen, Johannes / Kleber, Marcus E / Li, Xiaohui / Luan, Jian'an / Lyytikäinen, Leo-Pekka / Magnusson, Patrik K E / Mangino, Massimo / Mihailov, Evelin / Montasser, May E / Müller-Nurasyid, Martina / Nolte, Ilja M / O'Connell, Jeffrey R / Palmer, Cameron D / Perola, Markus / Petersen, Ann-Kristin / Sanna, Serena / Saxena, Richa / Service, Susan K / Shah, Sonia / Shungin, Dmitry / Sidore, Carlo / Song, Ci / Strawbridge, Rona J / Surakka, Ida / Tanaka, Toshiko / Teslovich, Tanya M / Thorleifsson, Gudmar / Van den Herik, Evita G / Voight, Benjamin F / Volcik, Kelly A / Waite, Lindsay L / Wong, Andrew / Wu, Ying / Zhang, Weihua / Absher, Devin / Asiki, Gershim / Barroso, Inês / Been, Latonya F / Bolton, Jennifer L / Bonnycastle, Lori L / Brambilla, Paolo / Burnett, Mary S / Cesana, Giancarlo / Dimitriou, Maria / Doney, Alex S F / Döring, Angela / Elliott, Paul / Epstein, Stephen E / Ingi Eyjolfsson, Gudmundur / Gigante, Bruna / Goodarzi, Mark O / Grallert, Harald / Gravito, Martha L / Groves, Christopher J / Hallmans, Göran / Hartikainen, Anna-Liisa / Hayward, Caroline / Hernandez, Dena / Hicks, Andrew A / Holm, Hilma / Hung, Yi-Jen / Illig, Thomas / Jones, Michelle R / Kaleebu, Pontiano / Kastelein, John J P / Khaw, Kay-Tee / Kim, Eric / Klopp, Norman / Komulainen, Pirjo / Kumari, Meena / Langenberg, Claudia / Lehtimäki, Terho / Lin, Shih-Yi / Lindström, Jaana / Loos, Ruth J F / Mach, François / McArdle, Wendy L / Meisinger, Christa / Mitchell, Braxton D / Müller, Gabrielle / Nagaraja, Ramaiah / Narisu, Narisu / Nieminen, Tuomo V M / Nsubuga, Rebecca N / Olafsson, Isleifur / Ong, Ken K / Palotie, Aarno / Papamarkou, Theodore / Pomilla, Cristina / Pouta, Anneli / Rader, Daniel J / Reilly, Muredach P / Ridker, Paul M / Rivadeneira, Fernando / Rudan, Igor / Ruokonen, Aimo / Samani, Nilesh / Scharnagl, Hubert / Seeley, Janet / Silander, Kaisa / Stančáková, Alena / Stirrups, Kathleen / Swift, Amy J / Tiret, Laurence / Uitterlinden, Andre G / van Pelt, L Joost / Vedantam, Sailaja / Wainwright, Nicholas / Wijmenga, Cisca / Wild, Sarah H / Willemsen, Gonneke / Wilsgaard, Tom / Wilson, James F / Young, Elizabeth H / Zhao, Jing Hua / Adair, Linda S / Arveiler, Dominique / Assimes, Themistocles L / Bandinelli, Stefania / Bennett, Franklyn / Bochud, Murielle / Boehm, Bernhard O / Boomsma, Dorret I / Borecki, Ingrid B / Bornstein, Stefan R / Bovet, Pascal / Burnier, Michel / Campbell, Harry / Chakravarti, Aravinda / Chambers, John C / Chen, Yii-Der Ida / Collins, Francis S / Cooper, Richard S / Danesh, John / Dedoussis, George / de Faire, Ulf / Feranil, Alan B / Ferrières, Jean / Ferrucci, Luigi / Freimer, Nelson B / Gieger, Christian / Groop, Leif C / Gudnason, Vilmundur / Gyllensten, Ulf / Hamsten, Anders / Harris, Tamara B / Hingorani, Aroon / Hirschhorn, Joel N / Hofman, Albert / Hovingh, G Kees / Hsiung, Chao Agnes / Humphries, Steve E / Hunt, Steven C / Hveem, Kristian / Iribarren, Carlos / Järvelin, Marjo-Riitta / Jula, Antti / Kähönen, Mika / Kaprio, Jaakko / Kesäniemi, Antero / Kivimaki, Mika / Kooner, Jaspal S / Koudstaal, Peter J / Krauss, Ronald M / Kuh, Diana / Kuusisto, Johanna / Kyvik, Kirsten O / Laakso, Markku / Lakka, Timo A / Lind, Lars / Lindgren, Cecilia M / Martin, Nicholas G / März, Winfried / McCarthy, Mark I / McKenzie, Colin A / Meneton, Pierre / Metspalu, Andres / Moilanen, Leena / Morris, Andrew D / Munroe, Patricia B / Njølstad, Inger / Pedersen, Nancy L / Power, Chris / Pramstaller, Peter P / Price, Jackie F / Psaty, Bruce M / Quertermous, Thomas / Rauramaa, Rainer / Saleheen, Danish / Salomaa, Veikko / Sanghera, Dharambir K / Saramies, Jouko / Schwarz, Peter E H / Sheu, Wayne H-H / Shuldiner, Alan R / Siegbahn, Agneta / Spector, Tim D / Stefansson, Kari / Strachan, David P / Tayo, Bamidele O / Tremoli, Elena / Tuomilehto, Jaakko / Uusitupa, Matti / van Duijn, Cornelia M / Vollenweider, Peter / Wallentin, Lars / Wareham, Nicholas J / Whitfield, John B / Wolffenbuttel, Bruce H R / Ordovas, Jose M / Boerwinkle, Eric / Palmer, Colin N A / Thorsteinsdottir, Unnur / Chasman, Daniel I / Rotter, Jerome I / Franks, Paul W / Ripatti, Samuli / Cupples, L Adrienne / Sandhu, Manjinder S / Rich, Stephen S / Boehnke, Michael / Deloukas, Panos / Kathiresan, Sekar / Mohlke, Karen L / Ingelsson, Erik / Abecasis, Gonçalo R / Anonymous3140771. ·Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan, Ann Arbor, Michigan 48109, USA. · Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, Michigan 48109, USA. · Department of Human Genetics, University of Michigan, Ann Arbor, Michigan 48109, USA. · Center for Statistical Genetics, Department of Biostatistics, University of Michigan, Ann Arbor, Michigan 48109, USA. · Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts 02118, USA. · Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. · Broad Institute, Program in Medical and Population Genetics, Cambridge, Massachusetts 02142, USA. · Department of Medical Sciences, Molecular Epidemiology, Uppsala University, Uppsala, Sweden. · Science for Life Laboratory, Uppsala University, Uppsala, Sweden. · Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, CB10 1SA, Hinxton, United Kingdom. · Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. · Department of Genetics, University of North Carolina, Chapel Hill, NC 27599 USA. · Division of Preventive Medicine, Brigham and Women's Hospital, 900 Commonwealth Ave., Boston MA 02215, USA. · Harvard Medical School, Boston MA 02115, USA. · Service of Medical Genetics, Lausanne University Hospital, Lausanne, Switzerland. · Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. · Division of Preventive Medicine and Health Services Research, Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. · Genetic Epidemiology Unit, Department of Epidemiology, Erasmus University Medical Center, Rotterdam, The Netherlands. · Department of Neurology, Erasmus Medical Center, Rotterdam, The Netherlands. · Medical Research Institute, University of Dundee, Ninewells Hospital and Medical School. Dundee, DD1 9SY, United Kingdom. · Cardiology, Department of Specialities of Medicine, Geneva University Hospital, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland. · Center for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA. · Estonian Genome Center of the University of Tartu, Tartu, Estonia. · Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia. · Department of Genetics, Washington University School of Medicine, USA. · Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, OX3 7BN, United Kingdom. · Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, EH8 9AG, Scotland, United Kingdom. · Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom. · Hjelt Institute, Department of Public Health, University of Helsinki, Finland. · Centre For Paediatric Epidemiology and Biostatistics/MRC Centre of Epidemiology for Child Health, University College of London Institute of Child Health, London, United Kingdom. · Centre for Medical Systems Biology, Leiden, the Netherlands. · Department of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden. · Uppsala Clinical Research Center, Uppsala University, Uppsala, Sweden. · Genome Centre, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. · Clinical Pharmacology, NIHR Cardiovascular Biomedical Research Unit, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry Queen Mary University of London, London, UK. · Biocenter Oulu, University of Oulu, Oulu, Finland. · Institute of Health Sciences, University of Oulu, Finland. · Institute for Molecular Medicine Finland FIMM, University of Helsinki, Finland. · Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland. · Department of Internal Medicine II - Cardiology, University of Ulm Medical Centre, Ulm, Germany. · Mannheim Institute of Public Health, Social and Preventive Medicine, Medical Faculty of Mannheim, University of Heidelberg, Ludolf-Krehl-Strasse 7-11, 68167 Mannheim, Germany. · Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. · MRC Epidemiology Unit, Institute of Metabolic Science, Box 285, Addenbrooke's Hospital, Hills Road, Cambridge, CB2 0QQ, United Kingdom. · Department of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland. · Department of Clinical Chemistry, University of Tampere School of Medicine, Tampere 33014, Finland. · Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom. · Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, Maryland. · Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany. · Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians University, Munich, Germany. · Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University of Munich, Munich, Germany. · Department of Epidemiology, University of Groningen, University Medical Center Groningen, The Netherlands. · Division of Endocrinology, Children's Hospital Boston, Massachusetts 02115, USA. · Division of Genetics, Program in Genomics, Children's Hospital, Boston, Massachusetts 02115, USA. · Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, 09042, Italy. · Massachusetts General Hospital/Broad Institute, Harvard University, Cambridge, MA, USA. · Center for Neurobehavioral Genetics, The Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, USA. · Genetic Epidemiology Group, Deparment of Epidemiology and Public Health, UCL, London WC1E 6BT, United Kingdom. · Department of Clinical Sciences, Genetic & Molecular Epidemiology Unit, Lund University Diabetes Center, Scania University Hosptial, Malmö, Sweden. · Department of Odontology, Umeå University, Umeå, Sweden. · Department of Public Health and Primary Care, Unit of Medicine, Umeå University, Umeå, Sweden. · Dipartimento di Scienze Biomediche, Universita di Sassari, 07100 SS, Italy. · Atherosclerosis Research Unit, Department of Medicine Solna, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. · Center for Molecular Medicine, Karolinska University Hospital, Stockholm, Sweden. · Clinical Research Branch, National Institute Health, Baltimore, MD, USA. · deCODE Genetics/Amgen, 101 Reykjavik, Iceland. · Department of Genetics, University of Pennsylvania - School of Medicine, Philadelphia PA, 19104, USA. · Department of Systems Pharmacology and Translational Therapeutics, University of Pennsylvania - School of Medicine, Philadelphia PA, 19104, USA. · Human Genetics Center, University of Texas Health Science Center - School of Public Health, Houston, TX 77030, USA. · HudsonAlpha Institute for Biotechnology, Huntsville, AL, USA. · MRC Unit for Lifelong Health and Ageing, 33 Bedford Place, London, WC1B 5JU, United Kingdom. · Department of Epidemiology and Biostatistics, School of Public Health, Imperial College London, London, United Kingdom. · Ealing Hospital, Southall, Middlesex UB1 3HW, United Kingdom. · MRC/UVRI Uganda Research Unit on AIDS, Entebbe, Uganda. · University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Level 4, Institute of Metabolic Science Box 289 Addenbrooke's Hospital Cambridge CB2 OQQ, UK. · Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. · Genome Technology Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA. · Department of Experimental Medicine, University of Milano Bicocca, Italy. · MedStar Health Research Institute, 6525 Belcrest Road, Suite 700, Hyattsville, MD 20782, USA. · Research Centre on Public Health, University of Milano Bicocca, Italy. · Department of Dietetics-Nutrition, Harokopio University, 70 El. Venizelou Str, Athens, Greece. · Institute of Epidemiology I, Helmholtz Zentrum München, Neuherberg 85764, Germany. · Institute of Epidemiology II, Helmholtz Zentrum München, Neuherberg 85764, Germany. · Department of Epidemiology and Biostatistics, MRC Health Protection Agency (HPA) Centre for Environment and Health, School of Public Health, Imperial College London, UK. · The Laboratory in Mjodd, 108 Reykjavik, Iceland. · Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. · Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA. · Research Unit of Molecular Epidemiology, Helmholtz Zentrum München, Neuherberg 85764, Germany. · Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, OX3 7LJ, United Kingdom. · Department of Public Health and Clinical Medicine, Nutritional research, Umeå University, Umeå, Sweden. · Department of Clinical Sciences/Obstetrics and Gynecology, Oulu University Hospital, Oulu, Finland. · MRC Human Genetics Unit, Institute of Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, United Kingdom. · Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA. · Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy - Affiliated Institute of the University of Lübeck, Lübeck, Germany. · Division of Endocrinology & Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan. · Hannover Unified Biobank, Hannover Medical School, Hannover 30625, Germany. · Department of Vascular Medicine, Academic Medical Center, Amsterdam, The Netherlands. · Clinical Gerontology Unit, University of Cambridge, Cambridge, United Kingdom. · Kuopio Research Institute of Exercise Medicine, Kuopio, Finland. · Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, School of Medicine, National Yang-Ming University, Taipei, Taiwan. · Diabetes Prevention Unit, National Institute for Health and Welfare, 00271 Helsinki, Finland. · The Genetics of Obesity and Related Metabolic Traits Program, The Icahn School of Medicine at Mount Sinai, New York, USA. · The Charles Bronfman Institute for Personalized Medicine, The Icahn School of Medicine at ount Sinai, New York, USA. · The Mindich Child Health and Development Institute, The Icahn School of Medicine at Mount Sinai, New York. · School of Social and Community Medicine, University of Bristol, Oakfield House, Oakfield Grove, Bristol BS8 2BN, United Kingdom. · Institute for Medical Informatics and Biometrics, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany. · Laboratory of Genetics, National Institute on Aging, Baltimore, MD21224, USA. · Department of Clinical Pharmacology, University of Tampere School of Medicine, Tamperew 33014, Finland. · Department of Internal Medicine, Päijät-Häme Central Hospital, Lahti, Finland. · Division of Cardiology, Helsinki University Central Hospital, Helsinki, Finland. · Department of Clinical Biochemistry, Landspitali University Hospital, 101 Reykjavik, Iceland. · Department of Medical Genetics, Haartman Institute, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland. · Genetic Epidemiology Group, Wellcome Trust Sanger Institute, Hinxton, Cambridge, United ingdom. · Department of Statistical Sciences, University College of London, London, United Kingdom. · National Institute for Health and Welfare, Oulu, Finland. · Cardiovascular Institute, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA. · Division of Translational Medicine and Human Genetics, Perelman School of Medicine at the University of Pennsylvania, 3400 Civic Center Blvd, Building 421, Translational Research Center, Philadelphia, PA 19104-5158, USA. · Department of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands. · Department of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands. · Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging NCHA), Leiden, The Netherlands. · Department of Clinical Sciences/Clinical Chemistry, University of Oulu, Oulu, Finland. · National Institute for Health Research Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK. · Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, LE3 9QP, UK. · Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Austria. · School of International Development, University of East Anglia, Norwich NR4 7TJ, United Kingdom. · University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland. · INSERM UMRS 937, Pierre and Marie Curie University, Paris, France. · Department of Laboratory Medicine, University of Groningen, University Medical Center Groningen, The Netherlands. · LifeLines Cohort Study, University of Groningen, University Medical Center Groningen, The Netherlands. · Department of Genetics, University of Groningen, University Medical Center Groningen, The Netherlands. · Department of Biological Psychology, VU Univ, Amsterdam, The Netherlands. · Department of Community Medicine, Faculty of Health Sciences, University of Tromsø, Tromsø, Norway. · Department of Nutrition, University of North Carolina, Chapel Hill, NC, USA. · Department of Epidemiology and Public Health, EA 3430, University of Strasbourg, Faculty of Medicine, Strasbourg, France. · Department of Medicine, Stanford University School of Medicine, Stanford, CA, USA. · Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy. · Chemical Pathology, Department of Pathology, University of the West Indies, Mona, Kingston 7, Jamaica. · Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, Route de la Corniche 10, 1010 Lausanne, Switzerland. · Division of Endocrinology and Diabetes, Department of Internal Medicine, Ulm University Medical Centre, Ulm, Germany. · Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore. · Department of Medicine III, University of Dresden, Medical Faculty Carl Gustav Carus, Fetscherstrasse 74, 01307 Dresden, Germany. · Ministry of Health, Victoria, Republic of Seychelles. · Service of Nephrology, Lausanne University Hospital, Lausanne, Switzerland. · Imperial College Healthcare NHS Trust, London, United Kingdom. · Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California, USA. · Department of Medicine, University of California Los Angeles, Los Angeles, California, USA. · Department of Preventive Medicine and Epidemiology, Loyola University Medical School, Maywood, Illinois 60153, USA. · Office of Population Studies Foundation, University of San Carlos, Talamban, Cebu City, Philippines. · Department of Cardiology, Toulouse University School of Medicine, Rangueil Hospital, Toulouse, France. · Department of Psychiatry, University of California, Los Angeles, USA. · Department of Clinical Sciences, Lund University, SE-20502, Malmö, Sweden. · Department of Medicine, Helsinki University Hospital, FI-00029 Helsinki, Finland. · Icelandic Heart Association, Kopavogur, Iceland. · Department of Cardiology, Karolinska University Hospital, Stockholm, Sweden. · Laboratory of Epidemiology, Demography, and Biometry, National Institute on Ageing, Bethesda, MD, USA. · Institute of Population Health Sciences, National Health Research Institutes, Zhunan, Taiwan. · Cardiovascular Genetics, BHF Laboratories, Institute Cardiovascular Science, University College London, London, United Kingdom. · Cardiovascular Genetics, University of Utah School of Medicine, Salt Lake City, UT, USA. · HUNT Research Centre, Department of Public Health and General Practice, Norwegian University of Science and Technology, Levanger, Norway. · Kaiser Permanente, Division of Research, Oakland, CA, USA. · Unit of Primary Care, Oulu University Hospital, Oulu, Finland. · Department of Chronic Disease Prevention, National Institute for Health and Welfare, Turku, Finland. · Department of Clinical Physiology, University of Tampere School of Medicine, Tampere 33014, Finland. · Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland. · Institute of Clinical Medicine, Department of Medicine, University of Oulu and Clinical Research Center, Oulu University Hospital, Oulu, Finland. · National Heart & Lung Institute, Imperial College London, Hammersmith Hospital, London, United Kingdom. · Children's Hospital Oakland Research Institute, 5700 Martin Luther King Junior Way, Oakland, CA 94609, USA. · Department of Medicine, University of Eastern Finland and Kuopio University Hospital, 70210 Kuopio, Finland. · Institute of Regional Health Services Research, University of Southern Denmark, Odense, Denmark. · Odense Patient data Explorative Network (OPEN), Odense University Hospital, Odense, Denmark. · Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Finland. · Department of Medical Sciences, Uppsala University, Uppsala, Sweden. · Queensland Institute of Medical Research, Locked Bag 2000, Royal Brisbane Hospital, Queensland 4029, Australia. · Synlab Academy, Synlab Services GmbH,Gottlieb-Daimler-Straße 25, 68165 Mannheim, Germany. · Tropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona, Kingston 7, Jamaica. · U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006 Paris, France. · Department of Medicine, Kuopio University Hospital, Kuopio, Finland. · Department of Neurology, General Central Hospital, Bolzano, Italy. · Department of Neurology, University of Lübeck, Lübeck, Germany. · Cardiovascular Health Research Unit, Departments of Medicine, Epidemiology, and Health Services, University of Washington, Seattle, WA, USA. · Group Health Research Institute, Group Health Cooperative, Seattle, WA, USA. · Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. · Center for Non-Communicable Diseases, Karachi, Pakistan. · Department of Medicine, University of Pennsylvania, USA. · Unit of Chronic Disease Epidemiology and Prevention, National Institute for Health and Welfare, Helsinki, Finland. · South Karelia Central Hospital, Lappeenranta, Finland. · Paul Langerhans Institute Dresden, German Center for Diabetes Research (DZD), Dresden, Germany. · Division of Endocrine and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan. · Geriatric Research and Education Clinical Center, Veterans Administration Medical Center, Baltimore, Maryland. · Faculty of Medicine, University of Iceland, 101 Reykjavík, Iceland. · Division of Population Health Sciences and Education, St George's, University of London, Cranmer Terrace, London SW17 0RE, United Kingdom. · Department of Pharmacological Sciences, University of Milan, Monzino Cardiology Center, IRCCS, Milan, Italy. · Centre for Vascular Prevention, Danube-University Krems, 3500 Krems, Austria. · King Abdulaziz University, Faculty of Medicine, Jeddah 21589, Saudi Arabia. · Red RECAVA Grupo RD06/0014/0015, Hospital Universitario La Paz, 28046. · Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Finland. · Research Unit, Kuopio University Hospital, Kuopio, Finland. · Department of Medicine, Lausanne University Hospital, Switzerland. · Department of Endocrinology, University of Groningen, University Medical Center Groningen, The Netherlands. · Department of Cardiovascular Epidemiology and Population Genetics, National Center for rdiovascular Investigation, Madrid, Spain. · IMDEA-Alimentacion, Madrid, Spain. · Nutrition and Genomics Laboratory, Jean Mayer-USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA, USA. · Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. · Framingham Heart Study, Framingham, MA, USA. · Center for Public Health Genomics, University of Virginia, Charlottesville, VA 22908, USA. · Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA. · Department of Medicine, Harvard Medical School, Boston, Massachusetts 02115, USA. ·Nat Genet · Pubmed #24097068.

ABSTRACT: Levels of low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, triglycerides and total cholesterol are heritable, modifiable risk factors for coronary artery disease. To identify new loci and refine known loci influencing these lipids, we examined 188,577 individuals using genome-wide and custom genotyping arrays. We identify and annotate 157 loci associated with lipid levels at P < 5 × 10(-8), including 62 loci not previously associated with lipid levels in humans. Using dense genotyping in individuals of European, East Asian, South Asian and African ancestry, we narrow association signals in 12 loci. We find that loci associated with blood lipid levels are often associated with cardiovascular and metabolic traits, including coronary artery disease, type 2 diabetes, blood pressure, waist-hip ratio and body mass index. Our results demonstrate the value of using genetic data from individuals of diverse ancestry and provide insights into the biological mechanisms regulating blood lipids to guide future genetic, biological and therapeutic research.

9 Article Common variants associated with plasma triglycerides and risk for coronary artery disease. 2013

Do, Ron / Willer, Cristen J / Schmidt, Ellen M / Sengupta, Sebanti / Gao, Chi / Peloso, Gina M / Gustafsson, Stefan / Kanoni, Stavroula / Ganna, Andrea / Chen, Jin / Buchkovich, Martin L / Mora, Samia / Beckmann, Jacques S / Bragg-Gresham, Jennifer L / Chang, Hsing-Yi / Demirkan, Ayşe / Den Hertog, Heleen M / Donnelly, Louise A / Ehret, Georg B / Esko, Tõnu / Feitosa, Mary F / Ferreira, Teresa / Fischer, Krista / Fontanillas, Pierre / Fraser, Ross M / Freitag, Daniel F / Gurdasani, Deepti / Heikkilä, Kauko / Hyppönen, Elina / Isaacs, Aaron / Jackson, Anne U / Johansson, Asa / Johnson, Toby / Kaakinen, Marika / Kettunen, Johannes / Kleber, Marcus E / Li, Xiaohui / Luan, Jian'an / Lyytikäinen, Leo-Pekka / Magnusson, Patrik K E / Mangino, Massimo / Mihailov, Evelin / Montasser, May E / Müller-Nurasyid, Martina / Nolte, Ilja M / O'Connell, Jeffrey R / Palmer, Cameron D / Perola, Markus / Petersen, Ann-Kristin / Sanna, Serena / Saxena, Richa / Service, Susan K / Shah, Sonia / Shungin, Dmitry / Sidore, Carlo / Song, Ci / Strawbridge, Rona J / Surakka, Ida / Tanaka, Toshiko / Teslovich, Tanya M / Thorleifsson, Gudmar / Van den Herik, Evita G / Voight, Benjamin F / Volcik, Kelly A / Waite, Lindsay L / Wong, Andrew / Wu, Ying / Zhang, Weihua / Absher, Devin / Asiki, Gershim / Barroso, Inês / Been, Latonya F / Bolton, Jennifer L / Bonnycastle, Lori L / Brambilla, Paolo / Burnett, Mary S / Cesana, Giancarlo / Dimitriou, Maria / Doney, Alex S F / Döring, Angela / Elliott, Paul / Epstein, Stephen E / Eyjolfsson, Gudmundur Ingi / Gigante, Bruna / Goodarzi, Mark O / Grallert, Harald / Gravito, Martha L / Groves, Christopher J / Hallmans, Göran / Hartikainen, Anna-Liisa / Hayward, Caroline / Hernandez, Dena / Hicks, Andrew A / Holm, Hilma / Hung, Yi-Jen / Illig, Thomas / Jones, Michelle R / Kaleebu, Pontiano / Kastelein, John J P / Khaw, Kay-Tee / Kim, Eric / Klopp, Norman / Komulainen, Pirjo / Kumari, Meena / Langenberg, Claudia / Lehtimäki, Terho / Lin, Shih-Yi / Lindström, Jaana / Loos, Ruth J F / Mach, François / McArdle, Wendy L / Meisinger, Christa / Mitchell, Braxton D / Müller, Gabrielle / Nagaraja, Ramaiah / Narisu, Narisu / Nieminen, Tuomo V M / Nsubuga, Rebecca N / Olafsson, Isleifur / Ong, Ken K / Palotie, Aarno / Papamarkou, Theodore / Pomilla, Cristina / Pouta, Anneli / Rader, Daniel J / Reilly, Muredach P / Ridker, Paul M / Rivadeneira, Fernando / Rudan, Igor / Ruokonen, Aimo / Samani, Nilesh / Scharnagl, Hubert / Seeley, Janet / Silander, Kaisa / Stančáková, Alena / Stirrups, Kathleen / Swift, Amy J / Tiret, Laurence / Uitterlinden, Andre G / van Pelt, L Joost / Vedantam, Sailaja / Wainwright, Nicholas / Wijmenga, Cisca / Wild, Sarah H / Willemsen, Gonneke / Wilsgaard, Tom / Wilson, James F / Young, Elizabeth H / Zhao, Jing Hua / Adair, Linda S / Arveiler, Dominique / Assimes, Themistocles L / Bandinelli, Stefania / Bennett, Franklyn / Bochud, Murielle / Boehm, Bernhard O / Boomsma, Dorret I / Borecki, Ingrid B / Bornstein, Stefan R / Bovet, Pascal / Burnier, Michel / Campbell, Harry / Chakravarti, Aravinda / Chambers, John C / Chen, Yii-Der Ida / Collins, Francis S / Cooper, Richard S / Danesh, John / Dedoussis, George / de Faire, Ulf / Feranil, Alan B / Ferrières, Jean / Ferrucci, Luigi / Freimer, Nelson B / Gieger, Christian / Groop, Leif C / Gudnason, Vilmundur / Gyllensten, Ulf / Hamsten, Anders / Harris, Tamara B / Hingorani, Aroon / Hirschhorn, Joel N / Hofman, Albert / Hovingh, G Kees / Hsiung, Chao Agnes / Humphries, Steve E / Hunt, Steven C / Hveem, Kristian / Iribarren, Carlos / Järvelin, Marjo-Riitta / Jula, Antti / Kähönen, Mika / Kaprio, Jaakko / Kesäniemi, Antero / Kivimaki, Mika / Kooner, Jaspal S / Koudstaal, Peter J / Krauss, Ronald M / Kuh, Diana / Kuusisto, Johanna / Kyvik, Kirsten O / Laakso, Markku / Lakka, Timo A / Lind, Lars / Lindgren, Cecilia M / Martin, Nicholas G / März, Winfried / McCarthy, Mark I / McKenzie, Colin A / Meneton, Pierre / Metspalu, Andres / Moilanen, Leena / Morris, Andrew D / Munroe, Patricia B / Njølstad, Inger / Pedersen, Nancy L / Power, Chris / Pramstaller, Peter P / Price, Jackie F / Psaty, Bruce M / Quertermous, Thomas / Rauramaa, Rainer / Saleheen, Danish / Salomaa, Veikko / Sanghera, Dharambir K / Saramies, Jouko / Schwarz, Peter E H / Sheu, Wayne H-H / Shuldiner, Alan R / Siegbahn, Agneta / Spector, Tim D / Stefansson, Kari / Strachan, David P / Tayo, Bamidele O / Tremoli, Elena / Tuomilehto, Jaakko / Uusitupa, Matti / van Duijn, Cornelia M / Vollenweider, Peter / Wallentin, Lars / Wareham, Nicholas J / Whitfield, John B / Wolffenbuttel, Bruce H R / Altshuler, David / Ordovas, Jose M / Boerwinkle, Eric / Palmer, Colin N A / Thorsteinsdottir, Unnur / Chasman, Daniel I / Rotter, Jerome I / Franks, Paul W / Ripatti, Samuli / Cupples, L Adrienne / Sandhu, Manjinder S / Rich, Stephen S / Boehnke, Michael / Deloukas, Panos / Mohlke, Karen L / Ingelsson, Erik / Abecasis, Goncalo R / Daly, Mark J / Neale, Benjamin M / Kathiresan, Sekar. ·1] Cardiovascular Research Center, Massachusetts General Hospital, Boston, Massachusetts, USA. [2] Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA. [3] Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA. [4] Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA. ·Nat Genet · Pubmed #24097064.

ABSTRACT: Triglycerides are transported in plasma by specific triglyceride-rich lipoproteins; in epidemiological studies, increased triglyceride levels correlate with higher risk for coronary artery disease (CAD). However, it is unclear whether this association reflects causal processes. We used 185 common variants recently mapped for plasma lipids (P < 5 × 10(-8) for each) to examine the role of triglycerides in risk for CAD. First, we highlight loci associated with both low-density lipoprotein cholesterol (LDL-C) and triglyceride levels, and we show that the direction and magnitude of the associations with both traits are factors in determining CAD risk. Second, we consider loci with only a strong association with triglycerides and show that these loci are also associated with CAD. Finally, in a model accounting for effects on LDL-C and/or high-density lipoprotein cholesterol (HDL-C) levels, the strength of a polymorphism's effect on triglyceride levels is correlated with the magnitude of its effect on CAD risk. These results suggest that triglyceride-rich lipoproteins causally influence risk for CAD.

10 Article Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. 2011

Anonymous650705 / Ehret, Georg B / Munroe, Patricia B / Rice, Kenneth M / Bochud, Murielle / Johnson, Andrew D / Chasman, Daniel I / Smith, Albert V / Tobin, Martin D / Verwoert, Germaine C / Hwang, Shih-Jen / Pihur, Vasyl / Vollenweider, Peter / O'Reilly, Paul F / Amin, Najaf / Bragg-Gresham, Jennifer L / Teumer, Alexander / Glazer, Nicole L / Launer, Lenore / Zhao, Jing Hua / Aulchenko, Yurii / Heath, Simon / Sõber, Siim / Parsa, Afshin / Luan, Jian'an / Arora, Pankaj / Dehghan, Abbas / Zhang, Feng / Lucas, Gavin / Hicks, Andrew A / Jackson, Anne U / Peden, John F / Tanaka, Toshiko / Wild, Sarah H / Rudan, Igor / Igl, Wilmar / Milaneschi, Yuri / Parker, Alex N / Fava, Cristiano / Chambers, John C / Fox, Ervin R / Kumari, Meena / Go, Min Jin / van der Harst, Pim / Kao, Wen Hong Linda / Sjögren, Marketa / Vinay, D G / Alexander, Myriam / Tabara, Yasuharu / Shaw-Hawkins, Sue / Whincup, Peter H / Liu, Yongmei / Shi, Gang / Kuusisto, Johanna / Tayo, Bamidele / Seielstad, Mark / Sim, Xueling / Nguyen, Khanh-Dung Hoang / Lehtimäki, Terho / Matullo, Giuseppe / Wu, Ying / Gaunt, Tom R / Onland-Moret, N Charlotte / Cooper, Matthew N / Platou, Carl G P / Org, Elin / Hardy, Rebecca / Dahgam, Santosh / Palmen, Jutta / Vitart, Veronique / Braund, Peter S / Kuznetsova, Tatiana / Uiterwaal, Cuno S P M / Adeyemo, Adebowale / Palmas, Walter / Campbell, Harry / Ludwig, Barbara / Tomaszewski, Maciej / Tzoulaki, Ioanna / Palmer, Nicholette D / Anonymous660705 / Anonymous670705 / Anonymous680705 / Anonymous690705 / Anonymous700705 / Aspelund, Thor / Garcia, Melissa / Chang, Yen-Pei C / O'Connell, Jeffrey R / Steinle, Nanette I / Grobbee, Diederick E / Arking, Dan E / Kardia, Sharon L / Morrison, Alanna C / Hernandez, Dena / Najjar, Samer / McArdle, Wendy L / Hadley, David / Brown, Morris J / Connell, John M / Hingorani, Aroon D / Day, Ian N M / Lawlor, Debbie A / Beilby, John P / Lawrence, Robert W / Clarke, Robert / Hopewell, Jemma C / Ongen, Halit / Dreisbach, Albert W / Li, Yali / Young, J Hunter / Bis, Joshua C / Kähönen, Mika / Viikari, Jorma / Adair, Linda S / Lee, Nanette R / Chen, Ming-Huei / Olden, Matthias / Pattaro, Cristian / Bolton, Judith A Hoffman / Köttgen, Anna / Bergmann, Sven / Mooser, Vincent / Chaturvedi, Nish / Frayling, Timothy M / Islam, Muhammad / Jafar, Tazeen H / Erdmann, Jeanette / Kulkarni, Smita R / Bornstein, Stefan R / Grässler, Jürgen / Groop, Leif / Voight, Benjamin F / Kettunen, Johannes / Howard, Philip / Taylor, Andrew / Guarrera, Simonetta / Ricceri, Fulvio / Emilsson, Valur / Plump, Andrew / Barroso, Inês / Khaw, Kay-Tee / Weder, Alan B / Hunt, Steven C / Sun, Yan V / Bergman, Richard N / Collins, Francis S / Bonnycastle, Lori L / Scott, Laura J / Stringham, Heather M / Peltonen, Leena / Perola, Markus / Vartiainen, Erkki / Brand, Stefan-Martin / Staessen, Jan A / Wang, Thomas J / Burton, Paul R / Soler Artigas, Maria / Dong, Yanbin / Snieder, Harold / Wang, Xiaoling / Zhu, Haidong / Lohman, Kurt K / Rudock, Megan E / Heckbert, Susan R / Smith, Nicholas L / Wiggins, Kerri L / Doumatey, Ayo / Shriner, Daniel / Veldre, Gudrun / Viigimaa, Margus / Kinra, Sanjay / Prabhakaran, Dorairaj / Tripathy, Vikal / Langefeld, Carl D / Rosengren, Annika / Thelle, Dag S / Corsi, Anna Maria / Singleton, Andrew / Forrester, Terrence / Hilton, Gina / McKenzie, Colin A / Salako, Tunde / Iwai, Naoharu / Kita, Yoshikuni / Ogihara, Toshio / Ohkubo, Takayoshi / Okamura, Tomonori / Ueshima, Hirotsugu / Umemura, Satoshi / Eyheramendy, Susana / Meitinger, Thomas / Wichmann, H-Erich / Cho, Yoon Shin / Kim, Hyung-Lae / Lee, Jong-Young / Scott, James / Sehmi, Joban S / Zhang, Weihua / Hedblad, Bo / Nilsson, Peter / Smith, George Davey / Wong, Andrew / Narisu, Narisu / Stančáková, Alena / Raffel, Leslie J / Yao, Jie / Kathiresan, Sekar / O'Donnell, Christopher J / Schwartz, Stephen M / Ikram, M Arfan / Longstreth, W T / Mosley, Thomas H / Seshadri, Sudha / Shrine, Nick R G / Wain, Louise V / Morken, Mario A / Swift, Amy J / Laitinen, Jaana / Prokopenko, Inga / Zitting, Paavo / Cooper, Jackie A / Humphries, Steve E / Danesh, John / Rasheed, Asif / Goel, Anuj / Hamsten, Anders / Watkins, Hugh / Bakker, Stephan J L / van Gilst, Wiek H / Janipalli, Charles S / Mani, K Radha / Yajnik, Chittaranjan S / Hofman, Albert / Mattace-Raso, Francesco U S / Oostra, Ben A / Demirkan, Ayse / Isaacs, Aaron / Rivadeneira, Fernando / Lakatta, Edward G / Orru, Marco / Scuteri, Angelo / Ala-Korpela, Mika / Kangas, Antti J / Lyytikäinen, Leo-Pekka / Soininen, Pasi / Tukiainen, Taru / Würtz, Peter / Ong, Rick Twee-Hee / Dörr, Marcus / Kroemer, Heyo K / Völker, Uwe / Völzke, Henry / Galan, Pilar / Hercberg, Serge / Lathrop, Mark / Zelenika, Diana / Deloukas, Panos / Mangino, Massimo / Spector, Tim D / Zhai, Guangju / Meschia, James F / Nalls, Michael A / Sharma, Pankaj / Terzic, Janos / Kumar, M V Kranthi / Denniff, Matthew / Zukowska-Szczechowska, Ewa / Wagenknecht, Lynne E / Fowkes, F Gerald R / Charchar, Fadi J / Schwarz, Peter E H / Hayward, Caroline / Guo, Xiuqing / Rotimi, Charles / Bots, Michiel L / Brand, Eva / Samani, Nilesh J / Polasek, Ozren / Talmud, Philippa J / Nyberg, Fredrik / Kuh, Diana / Laan, Maris / Hveem, Kristian / Palmer, Lyle J / van der Schouw, Yvonne T / Casas, Juan P / Mohlke, Karen L / Vineis, Paolo / Raitakari, Olli / Ganesh, Santhi K / Wong, Tien Y / Tai, E Shyong / Cooper, Richard S / Laakso, Markku / Rao, Dabeeru C / Harris, Tamara B / Morris, Richard W / Dominiczak, Anna F / Kivimaki, Mika / Marmot, Michael G / Miki, Tetsuro / Saleheen, Danish / Chandak, Giriraj R / Coresh, Josef / Navis, Gerjan / Salomaa, Veikko / Han, Bok-Ghee / Zhu, Xiaofeng / Kooner, Jaspal S / Melander, Olle / Ridker, Paul M / Bandinelli, Stefania / Gyllensten, Ulf B / Wright, Alan F / Wilson, James F / Ferrucci, Luigi / Farrall, Martin / Tuomilehto, Jaakko / Pramstaller, Peter P / Elosua, Roberto / Soranzo, Nicole / Sijbrands, Eric J G / Altshuler, David / Loos, Ruth J F / Shuldiner, Alan R / Gieger, Christian / Meneton, Pierre / Uitterlinden, Andre G / Wareham, Nicholas J / Gudnason, Vilmundur / Rotter, Jerome I / Rettig, Rainer / Uda, Manuela / Strachan, David P / Witteman, Jacqueline C M / Hartikainen, Anna-Liisa / Beckmann, Jacques S / Boerwinkle, Eric / Vasan, Ramachandran S / Boehnke, Michael / Larson, Martin G / Järvelin, Marjo-Riitta / Psaty, Bruce M / Abecasis, Gonçalo R / Chakravarti, Aravinda / Elliott, Paul / van Duijn, Cornelia M / Newton-Cheh, Christopher / Levy, Daniel / Caulfield, Mark J / Johnson, Toby. · ·Nature · Pubmed #21909115.

ABSTRACT: Blood pressure is a heritable trait influenced by several biological pathways and responsive to environmental stimuli. Over one billion people worldwide have hypertension (≥140 mm Hg systolic blood pressure or  ≥90 mm Hg diastolic blood pressure). Even small increments in blood pressure are associated with an increased risk of cardiovascular events. This genome-wide association study of systolic and diastolic blood pressure, which used a multi-stage design in 200,000 individuals of European descent, identified sixteen novel loci: six of these loci contain genes previously known or suspected to regulate blood pressure (GUCY1A3-GUCY1B3, NPR3-C5orf23, ADM, FURIN-FES, GOSR2, GNAS-EDN3); the other ten provide new clues to blood pressure physiology. A genetic risk score based on 29 genome-wide significant variants was associated with hypertension, left ventricular wall thickness, stroke and coronary artery disease, but not kidney disease or kidney function. We also observed associations with blood pressure in East Asian, South Asian and African ancestry individuals. Our findings provide new insights into the genetics and biology of blood pressure, and suggest potential novel therapeutic pathways for cardiovascular disease prevention.

11 Article The impacts of thiazolidinediones on circulating C-reactive protein levels in different diseases: a meta-analysis. 2010

Zhao, Yulan / He, Xuelian / Huang, Chengjin / Fu, Xiaonan / Shi, Xuegui / Wu, Ying / Han, Yijie / Li, Naishi / Wu, Yanxiang / Heng, Chew-Kiat. ·Advanced Institute of NBIC Integrated Drug Discovery and Development, East China Normal University, Shanghai City 200062, PR China. ylzhao@imet.ecnu.edu.cn ·Diabetes Res Clin Pract · Pubmed #20926154.

ABSTRACT: OBJECTIVES: Thiazolidinediones (TZDs), including rosiglitazone and pioglitazone, are widely used as antidiabetic agents. Here we present an updated meta-analysis of the respective effects of rosiglitazone and pioglitazone on the levels of C-reactive protein (CRP), a biomarker and predictor of CAD risks. METHODS AND RESULTS: PubMed and EMBASE were systematically searched using the terms "C-reactive protein" and "rosiglitazone" or "pioglitazone" or "thiazolidinedione". A total of 59 rosiglitazone studies and 36 pioglitazone studies were included for evaluation. These were classified as 2-group studies and 1-group studies according to their study design. Standard mean difference (SMD) of CRP and 95% CI were calculated to evaluate the effect of TZDs on CRP. The overall SMD for rosiglitazone treatment is -0.392 (95% CI, [-0.446, -0.338]) in 2-group studies and -0.424 (95% CI, [-0.501, -0.346]) in 1-group studies. The overall SMD for pioglitazone treatment is -0.577 (95% CI, [-0.732, -0.421]) in 2-group studies and -0.327 (95% CI, [-0.439, -0.216]) in 1-group studies. Moreover, TZDs were found to significantly reduce CRP levels in both diabetes mellitus (DM) and non-DM patients. CONCLUSIONS: Our meta-analysis suggested that both rosiglitazone and pioglitazone significantly decrease serum CRP levels. TZDs presented their CRP-lowering effect in both DM and non-DM patients.