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Coronary Artery Disease: HELP
Articles by Geertruida H. de Bock
Based on 5 articles published since 2010
(Why 5 articles?)
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Between 2010 and 2020, G. H. de Bock wrote the following 5 articles about Coronary Artery Disease.
 
+ Citations + Abstracts
1 Review Diagnostic performance of semi-quantitative and quantitative stress CMR perfusion analysis: a meta-analysis. 2017

van Dijk, R / van Assen, M / Vliegenthart, R / de Bock, G H / van der Harst, P / Oudkerk, M. ·Center for Medical Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1 EB 45, Groningen, The Netherlands. · Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. · Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. · Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. · Center for Medical Imaging, University Medical Center Groningen, University of Groningen, Hanzeplein 1 EB 45, Groningen, The Netherlands. m.oudkerk@umcg.nl. ·J Cardiovasc Magn Reson · Pubmed #29178905.

ABSTRACT: BACKGROUND: Stress cardiovascular magnetic resonance (CMR) perfusion imaging is a promising modality for the evaluation of coronary artery disease (CAD) due to high spatial resolution and absence of radiation. Semi-quantitative and quantitative analysis of CMR perfusion are based on signal-intensity curves produced during the first-pass of gadolinium contrast. Multiple semi-quantitative and quantitative parameters have been introduced. Diagnostic performance of these parameters varies extensively among studies and standardized protocols are lacking. This study aims to determine the diagnostic accuracy of semi- quantitative and quantitative CMR perfusion parameters, compared to multiple reference standards. METHOD: Pubmed, WebOfScience, and Embase were systematically searched using predefined criteria (3272 articles). A check for duplicates was performed (1967 articles). Eligibility and relevance of the articles was determined by two reviewers using pre-defined criteria. The primary data extraction was performed independently by two researchers with the use of a predefined template. Differences in extracted data were resolved by discussion between the two researchers. The quality of the included studies was assessed using the 'Quality Assessment of Diagnostic Accuracy Studies Tool' (QUADAS-2). True positives, false positives, true negatives, and false negatives were subtracted/calculated from the articles. The principal summary measures used to assess diagnostic accuracy were sensitivity, specificity, andarea under the receiver operating curve (AUC). Data was pooled according to analysis territory, reference standard and perfusion parameter. RESULTS: Twenty-two articles were eligible based on the predefined study eligibility criteria. The pooled diagnostic accuracy for segment-, territory- and patient-based analyses showed good diagnostic performance with sensitivity of 0.88, 0.82, and 0.83, specificity of 0.72, 0.83, and 0.76 and AUC of 0.90, 0.84, and 0.87, respectively. In per territory analysis our results show similar diagnostic accuracy comparing anatomical (AUC 0.86(0.83-0.89)) and functional reference standards (AUC 0.88(0.84-0.90)). Only the per territory analysis sensitivity did not show significant heterogeneity. None of the groups showed signs of publication bias. CONCLUSIONS: The clinical value of semi-quantitative and quantitative CMR perfusion analysis remains uncertain due to extensive inter-study heterogeneity and large differences in CMR perfusion acquisition protocols, reference standards, and methods of assessment of myocardial perfusion parameters. For wide spread implementation, standardization of CMR perfusion techniques is essential. TRIAL REGISTRATION: CRD42016040176 .

2 Review Validation and prognosis of coronary artery calcium scoring in nontriggered thoracic computed tomography: systematic review and meta-analysis. 2013

Xie, Xueqian / Zhao, Yingru / de Bock, Geertruida H / de Jong, Pim A / Mali, Willem P / Oudkerk, Matthijs / Vliegenthart, Rozemarijn. ·Department of Radiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. ·Circ Cardiovasc Imaging · Pubmed #23756678.

ABSTRACT: BACKGROUND: Coronary calcium score (CS), traditionally based on electrocardiography-triggered computed tomography (CT), predicts cardiovascular risk. Currently, nontriggered thoracic CT is extensively used, such as in lung cancer screening. The purpose of the study was to determine the correlation in CS between nontriggered and electrocardiography-triggered CT, and to evaluate the prognostic performance of the CS derived from nontriggered CT. METHODS AND RESULTS: PubMed, Embase, and Web of Knowledge were searched until November 2012. Two reviewers independently screened 2120 records to identify studies reporting the CS in nontriggered CT and extracted information. Study quality was evaluated by standardized assessment tools. Cohen κ was extracted for agreement of CS categories between nontriggered and electrocardiography-triggered CT (validation). Hazard ratio (HR) was extracted for prognostic performance. Five studies about validation comprising 1316 individuals were included. Five studies about prognosis comprising 34 028 cardiac asymptomatic individuals, mainly from lung cancer screening trials, were included. All studies were of high quality. Meta-analysis could only be performed for validation studies because studies on prognostic performance were highly heterogeneous. Pooled Cohen κ for agreement between the 2 techniques was 0.89 (95% confidence interval, 0.83-0.95) for increasing CS categories. Increasing CS categories were associated with increasing risk of cardiovascular death or events. Nontriggered CT yielded false-negative CS in 8.8% of individuals and underestimated high CS in 19.1% of individuals. CONCLUSIONS: Our analysis shows the prognostic value and potential role of nontriggered assessment of coronary calcium, but it does not suggest that electrocardiography-triggered CT should be replaced by nontriggered examinations.

3 Article The Relationship of Coronary Artery Calcium and Clinical Coronary Artery Disease with Cognitive Function: A Systematic Review and Meta-Analysis. 2020

Xia, Congying / Vonder, Marleen / Sidorenkov, Grigory / Oudkerk, Matthijs / de Groot, Jan Cees / van der Harst, Pim / de Bock, Geertruida H / De Deyn, Peter Paul / Vliegenthart, Rozemarijin. ·University of Groningen, University Medical Center Groningen, Department of Radiology. · University of Groningen, University Medical Center Groningen, Department of Epidemiology. · University of Groningen, Faculty of Medical Sciences. · University of Groningen, University Medical Center Groningen, Department of Cardiology. · University of Groningen, University Medical Center Groningen, Department of Neurology, Alzheimer Center Groningen. ·J Atheroscler Thromb · Pubmed #32062643.

ABSTRACT: AIM: Coronary artery disease (CAD) and cognitive impairment are common in the elderly, with evidence for shared risk factors and pathophysiological processes. The coronary artery calcium (CAC) score is a marker of subclinical CAD, which may allow early detection of individuals prone to cognitive decline. Prior studies on associations of CAC and clinical CAD with cognitive impairment had discrepant results. This systematic review aims to evaluate the association of (sub)clinical CAD with cognitive function, cognitive decline, and diagnosis of mild cognitive impairment (MCI) or dementia. METHODS: A systematic search was conducted in MEDLINE, Embase, and Web of Science until February 2019, supplemented with citations tracking. Two reviewers independently screened studies and extracted information including odds ratios (ORs) and hazard ratios (HRs). RESULTS: Forty-six studies, 10 on CAC and 36 on clinical CAD, comprising 1,248,908 participants were included in the systematic review. Studies about associations of (sub)clinical CAD with cognitive function and cognitive decline had heterogeneous methodology and inconsistent findings. Two population-based studies investigated the association between CAC and risk of dementia over 6-12.2 years using different CAC scoring methods. Both found a tendency toward higher risk of dementia as CAC severity increased. Meta-analysis in 15 studies (663,250 individuals) showed an association between CAD and MCI/dementia (pooled OR 1.32, 95%CI 1.17-1.48) with substantial heterogeneity (I2=87.0%, p<0.001). Pooled HR of CAD for incident MCI/dementia over 3.2-25.5 years in six longitudinal studies (70,060 individuals) was 1.51 (95%CI 1.24-1.85), with low heterogeneity (I2=14.1%, p=0.32). Sensitivity analysis did not detect any study that was of particular influence on the pooled OR or HR. CONCLUSIONS: Limited evidence suggests the CAC score is associated with risk of dementia. In clinical CAD, risk of MCI and dementia is increased by 50%, as supported by stronger evidence.

4 Article Early imaging biomarkers of lung cancer, COPD and coronary artery disease in the general population: rationale and design of the ImaLife (Imaging in Lifelines) Study. 2020

Xia, Congying / Rook, Mieneke / Pelgrim, Gert Jan / Sidorenkov, Grigory / Wisselink, Hendrik J / van Bolhuis, Jurjen N / van Ooijen, Peter M A / Guo, Jiapan / Oudkerk, Matthijs / Groen, Harry / van den Berge, Maarten / van der Harst, Pim / Dijkstra, Hildebrand / Vonder, Marleen / Heuvelmans, Marjolein A / Dorrius, Monique D / De Deyn, Peter Paul / de Bock, Geertruida H / Dotinga, Aafje / Vliegenthart, Rozemarijn. ·Department of Radiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. · Martini Hospital Groningen, Groningen, The Netherlands. · Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. · Lifelines Cohort Study, Groningen, The Netherlands. · Department of Radiation Therapy, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. · iDNA B.V, Groningen, The Netherlands. · University of Groningen, Groningen, The Netherlands. · Department of Pulmonary Diseases, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. · Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. · Department of Neurology, University of Groningen, University Medical Center Groningen, Alzheimer Research Center, Groningen, The Netherlands. · Department of Radiology, University of Groningen, University Medical Center Groningen, Hanzeplein 1, 9713 GZ, Groningen, The Netherlands. r.vliegenthart@umcg.nl. ·Eur J Epidemiol · Pubmed #31016436.

ABSTRACT: Lung cancer, chronic obstructive pulmonary disease (COPD), and coronary artery disease (CAD) are expected to cause most deaths by 2050. State-of-the-art computed tomography (CT) allows early detection of lung cancer and simultaneous evaluation of imaging biomarkers for the early stages of COPD, based on pulmonary density and bronchial wall thickness, and of CAD, based on the coronary artery calcium score (CACS), at low radiation dose. To determine cut-off values for positive tests for elevated risk and presence of disease is one of the major tasks before considering implementation of CT screening in a general population. The ImaLife (Imaging in Lifelines) study, embedded in the Lifelines study, is designed to establish the reference values of the imaging biomarkers for the big three diseases in a well-defined general population aged 45 years and older. In total, 12,000 participants will undergo CACS and chest acquisitions with latest CT technology. The estimated percentage of individuals with lung nodules needing further workup is around 1-2%. Given the around 10% prevalence of COPD and CAD in the general population, the expected number of COPD and CAD is around 1000 each. So far, nearly 4000 participants have been included. The ImaLife study will allow differentiation between normal aging of the pulmonary and cardiovascular system and early stages of the big three diseases based on low-dose CT imaging. This information can be finally integrated into personalized precision health strategies in the general population.

5 Article High-pitch versus sequential mode for coronary calcium in individuals with a high heart rate: Potential for dose reduction. 2018

Vonder, Marleen / Vliegenthart, Rozemarijn / Kaatee, Merel A / van der Aalst, Carlijn M / van Ooijen, Peter M A / de Bock, Geertruida H / Gratama, Jan Willem / Kuijpers, Dirkjan / de Koning, Harry J / Oudkerk, Matthijs. ·University of Groningen, University Medical Center Groningen, Center for Medical Imaging North-East Netherlands (CMI-NEN), Groningen, The Netherlands. Electronic address: m.vonder@umcg.nl. · University of Groningen, University Medical Center Groningen, Center for Medical Imaging North-East Netherlands (CMI-NEN), Groningen, The Netherlands. Electronic address: r.vliegenthart@umcg.nl. · University of Groningen, University Medical Center Groningen, Center for Medical Imaging North-East Netherlands (CMI-NEN), Groningen, The Netherlands. Electronic address: m.a.kaatee@umcg.nl. · Erasmus MC, Dept. of Public Health, Rotterdam, The Netherlands. Electronic address: c.vanderaalst@erasmusmc.nl. · University of Groningen, University Medical Center Groningen, Center for Medical Imaging North-East Netherlands (CMI-NEN), Groningen, The Netherlands. Electronic address: p.m.a.van.ooijen@umcg.nl. · University of Groningen, University Medical Center Groningen, Department of Epidemiology, Groningen, The Netherlands. Electronic address: g.h.de.bock@umcg.nl. · University of Groningen, University Medical Center Groningen, Center for Medical Imaging North-East Netherlands (CMI-NEN), Groningen, The Netherlands; Gelre Ziekenhuizen, Dept. of Radiology, Apeldoorn, The Netherlands. Electronic address: j.w.gratama@gelre.nl. · University of Groningen, University Medical Center Groningen, Center for Medical Imaging North-East Netherlands (CMI-NEN), Groningen, The Netherlands; HMC-Bronovo, Dept. of Radiology, The Hague, The Netherlands. Electronic address: t.kuijpers@haaglandenmc.nl. · Erasmus MC, Dept. of Public Health, Rotterdam, The Netherlands. Electronic address: h.dekoning@erasmusmc.nl. · University of Groningen, University Medical Center Groningen, Center for Medical Imaging North-East Netherlands (CMI-NEN), Groningen, The Netherlands. Electronic address: m.oudkerk@umcg.nl. ·J Cardiovasc Comput Tomogr · Pubmed #29551663.

ABSTRACT: BACKGROUND: To determine the impact of high-pitch spiral acquisition on radiation dose and cardiovascular disease (CVD) risk stratification by coronary artery calcium (CAC) assessment with computed tomography in individuals with a high heart rate. METHODS: Of the ROBINSCA trial, 1990 participants with regular rhythm and heart rates >65 beats per minute (bpm) were included. As reference, 390 participants with regular heart rates ≤65 bpm were used. All participants underwent prospectively electrocardiographically(ECG)-triggered imaging of the coronary arteries using dual source CT at 120 kVp, 80 ref mAs using both high-pitch spiral mode and sequential mode. Radiation dose, Agatston score, number of positive scores, as well as median absolute difference of the Agatston score were determined and participants were stratified into CVD risk categories. RESULTS: A similar percentage of participants with low heart rates and high heart rates had a positive CAC score in data sets acquired in high-pitch spiral (low heart rate: 57.7%, high heart rate: 55.8%) and sequential mode (58.0%, 54.7%, p = n.s.). The median absolute difference in Agatston scores between acquisition modes was 14.2% and 9.2%, for the high and low heart rate groups, respectively. Excellent agreement for risk categorization between the two data acquisition modes was found for the high (κ = 0.927) and low (κ = 0.946) heart rate groups. Radiation dose was 48% lower for high-pitch spiral versus sequential acquisitions. CONCLUSION: Radiation dose for the quantification of coronary calcium can be reduced by 48% when using the high-pitch spiral acquisition mode compared to the sequential mode in participants with a regular high heart rate. CVD risk stratification agreement between the two modes of data acquisition is excellent.