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Coronary Artery Disease: HELP
Articles from Turkey
Based on 1,315 articles published since 2008

These are the 1315 published articles about Coronary Artery Disease that originated from Turkey during 2008-2019.
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14 · 15 · 16 · 17 · 18 · 19 · 20
1 Editorial [2017 ESC focused update on dual antiplatelet therapy in coronary artery disease developed in collaboration with EACTS: What is new?] 2018

Öngen, Zeki. ·Department of Cardiology, İstanbul University Cerrahpaşa Faculty of Medicine, İstanbul, Turkey. z_ongen@yahoo.com.tr. ·Turk Kardiyol Dern Ars · Pubmed #29339684.

ABSTRACT: -- No abstract --

2 Editorial Is glomerular filtration rate a marker of severity of coronary heart disease? 2016

Ecder, Tevfik. ·Department of Internal Medicine, Division of Nephrology, İstanbul Bilim University Faculty of Medicine, İstanbul, Turkey. ecder@istanbul.edu.tr. ·Turk Kardiyol Dern Ars · Pubmed #27111306.

ABSTRACT: -- No abstract --

3 Editorial Can heart rate turbulance be used to assess stable coronary artery disease and its severity? 2015

Demircan, Sabri. ·Department of Cardiology, Istanbul Science University, Istanbul, Turkey. ·Turk Kardiyol Dern Ars · Pubmed #26536981.

ABSTRACT: -- No abstract --

4 Editorial [Stable coronary artery disease management: what has changed in the 2013 European Society of Cardiology guideline?]. 2014

Ozpelit, M Emre / Pekel, Nihat / Tengiz, Istemihan. ·Department of Cardiology, İzmir University Medicalpark Hospital, İzmir, Turkey. ·Turk Kardiyol Dern Ars · Pubmed #24481088.

ABSTRACT: -- No abstract --

5 Review [Radial Approach for Percutaneous Coronary Interventions in Patients With Ischemic Heart Disease: Advantages and Disadvantages, Complications Rate in Comparison With Femoral Approach]. 2017

Fettser, D V / Batyraliev, T A / Pershukov, I V / Vanyukov, A E / Sidorenko, B A. ·City Clinical Hospital 52 Moscow, Russia. · University SANKO, Gaziantep, Turkey. · Central State Medical Academy, President Management Department RF, Moscow, Russia. ·Kardiologiia · Pubmed #28762920.

ABSTRACT: During recent 10-15 years, percutaneous coronary interventions (PCI) have reached a new level of efficacy and safety. Rate of serious coronary complications has decreased. That to a greater degree exposes the problem of peripheral complications at the site of arterial approach. At the same time portion of patients older than 75 years in the total pool of PCI constantly increases. Number of patients with pronounced obesity also grows each year. Radial approach for PCI allows to substantially decrease rate of peripheral complications at the account of lowered rate of bleedings, and to shorten duration of hospitalization. In this literature review we present results of a number of relevant clinical studies including those which contained groups of elderly patients and of patients with obesity. We also have summarized main advantages and disadvantages of radial approach as compared with femoral approach for coronary angiography and PCI.

6 Review Prostanoids in the pathophysiology of human coronary artery. 2017

Ozen, G / Norel, X. ·INSERM U1148, CHU X. Bichat, 46 rue H. Huchard, 75018 Paris, France; Faculty of Pharmacy, Department of Pharmacology, Istanbul University, Istanbul, Turkey. · INSERM U1148, CHU X. Bichat, 46 rue H. Huchard, 75018 Paris, France; Paris Nord University, Sorbonne Paris Cité, UMR-S1148, 75018 Paris, France. Electronic address: xavier.norel@inserm.fr. ·Prostaglandins Other Lipid Mediat · Pubmed #28347710.

ABSTRACT: Coronary artery disease is one of the leading causes of death in wordwide. There is growing evidence that prostanoids are involved in the physiology and pathophysiology of the human coronary artery by controlling vascular tone, remodelling of the vascular wall or angiogenesis. In this review, the production of prostanoids and the expression of prostanoid receptors in human coronary artery in health or disease are described. In addition, the interactions between sex hormones and prostanoids, their participations in the development of coronary artery diseases have been addressed. Globally, most of the studies performed in human coronary artery preparations have shown that prostacyclin (PGI

7 Review Antithrombotic Treatments for Stroke Prevention in Elderly Patients With Nonvalvular Atrial Fibrillation: Drugs and Doses. 2016

Kilickap, Mustafa / Bosch, Jackie / Eikelboom, John W / Hart, Robert G. ·Department of Cardiology, Ankara University School of Medicine, Ankara, Turkey. Electronic address: mkilickap@yahoo.com. · McMaster University Hamilton Health Sciences, Population Health Research Institute, Hamilton, Ontario, Canada. ·Can J Cardiol · Pubmed #27568871.

ABSTRACT: Atrial fibrillation (AF) is a common cardiac rhythm disturbance and is associated with a 5-fold increased risk of stroke. The most important risk factors for stroke in patients with AF are previous stroke and age ≥ 75 years. Canadian guidelines recommend anticoagulant therapy for patients with AF who are older than the age of 65 years, but the elderly often remain undertreated, primarily because of concerns regarding bleeding. Non-vitamin K oral anticoagulants appear to be safer, at least as efficacious, and more convenient than warfarin, and are a cost-effective alternative for elderly patients with AF. We review the evidence for the use of antithrombotic agents for stroke prevention in elderly patients (age ≥ 75 years) with nonvalvular AF.

8 Review Optimisation of percutaneous coronary intervention: indispensables for bioresorbable scaffolds. 2016

Tenekecioglu, Erhan / Bourantas, Christos V / Abdelghani, Mohammad / Sotomi, Yohei / Suwannasom, Pannipa / Tateishi, Hiroki / Onuma, Yoshinobu / Yılmaz, Mustafa / Serruys, Patrick W. ·a Department of Cardiology, ThoraxCentre , Erasmus Medical Center , Rotterdam , The Netherlands. · b Institute of Cardiovascular Sciences , University College of London , London , UK. · c Department of Cardiology , Barts Health NHS Trust , London , UK. · d Academic Medical Center , University of Amsterdam , Amsterdam , The Netherlands. · e Department of Cardiology , Bursa Postgraduate Research and Education Hospital , Bursa , Turkey. · f International Centre for Circulatory Health , Imperial College , London , UK. ·Expert Rev Cardiovasc Ther · Pubmed #27376592.

ABSTRACT: INTRODUCTION: With new developments in percutaneous coronary intervention (PCI), such as the introduction of bioresorbable scaffolds (BRS), percutaneous treatment of coronary artery diseases has entered a new era. Without metallic remnants, BRSs appear able to overcome several limitations of the existing metallic stents and provide a physiologic treatment of coronary artery pathology. AREAS COVERED: BRS have different mechanical properties compared to the traditional metallic stents that should be taken into account during their implantation. Lesion selection, device sizing and satisfied pre-dilatation should be implemented prudently. Although intravascular imaging is not mandatory for the implantation of BRSs it may have a value in optimizing device deployment assess final results and reduce the risk of device related adverse events such as re-stenosis, or scaffold thrombosis. This review aims to reveal the crucial points about the methods of optimization in each steps of BRS implantation. Expert commentary: The target lesions for BRS should be selected meticulously. Pre-dilatation, post-dilatation and intra-vascular imaging techniques should be implemented appropriately to avoid undesirable events after scaffold implantation.

9 Review An update on cardiovascular effects of obstructive sleep apnoea syndrome. 2016

Uyar, Meral / Davutoglu, Vedat. ·Department of Respiratory Medicine, Gaziantep University, Gaziantep, Turkey. · Department of Cardiology, Gaziantep University, Gaziantep, Turkey. ·Postgrad Med J · Pubmed #27317753.

ABSTRACT: Obstructive sleep apnoea syndrome is an important health problem which may cause or worsen systemic diseases. Chronic intermittent hypoxia during repetitive airflow cessations may cause endothelial dysfunction. Sleep apnoea is also shown to be associated with hypercoagulability which may be due to decreased nitric oxide levels and impaired vasodilatation. Endothelial dysfunction, increased systemic inflammation, sympathetic nervous system activation, increased oxidative stress and dysglycaemia may all contribute to cardiovascular processes such as hypertension, arrhythmia, stroke, heart failure and coronary artery disease in patients with obstructive sleep apnoea. Treatment approaches in patients with obstructive sleep apnoea mainly focus on maintaining upper airway patency either with positive airway pressure devices or upper airway appliances. Strategies involving positive airway pressure therapy are associated with decreased morbidity and mortality. Obstructive sleep apnoea should be suspected as an underlying mechanism in patients with cardiovascular disease and warrants appropriate treatment.

10 Review Bioresorbable scaffolds: a new paradigm in percutaneous coronary intervention. 2016

Tenekecioglu, Erhan / Farooq, Vasim / Bourantas, Christos V / Silva, Rafael Cavalcante / Onuma, Yoshinobu / Yılmaz, Mustafa / Serruys, Patrick W. ·ThoraxCentre, Erasmus Medical Centre, Rotterdam, The Netherlands. erhantenekecioglu@yahoo.com. · Manchester Heart Centre, Manchester Royal Infirmary, Central Manchester University, Hospitals NHS Trust, Manchester, UK. vasimfarooq@hotmail.com. · Institute of Cardiovascular Sciences, Manchester Academic Health Sciences Centre, University of Manchester, Manchester, UK. vasimfarooq@hotmail.com. · Institute of Cardiovascular Sciences, University College of London, London, UK. cbourantas@gmail.com. · Department of Cardiology, Barts Health NHS Trust, London, UK. cbourantas@gmail.com. · ThoraxCentre, Erasmus Medical Centre, Rotterdam, The Netherlands. rafacavasi@hotmail.com. · ThoraxCentre, Erasmus Medical Centre, Rotterdam, The Netherlands. yoshinobuonuma@gmail.com. · Department of Cardiology, Bursa Postgraduate Education and Research Hospital, Bursa, Turkey. mustafayih@yahoo.com.tr. · ThoraxCentre, Erasmus Medical Centre, Rotterdam, The Netherlands. patrick.w.j.c.serruys@gmail.com. · International Centre for Circulatory Health, Imperial College, London, UK. patrick.w.j.c.serruys@gmail.com. · Interventional Cardiology Department, Erasmus MC, 's-Gravendijkwal 230, Rotterdam, 3015 CE, The Netherlands. patrick.w.j.c.serruys@gmail.com. ·BMC Cardiovasc Disord · Pubmed #26868826.

ABSTRACT: Numerous advances and innovative therapies have been introduced in interventional cardiology over the recent years, since the first introduction of balloon angioplasty, but bioresorbable scaffold is certainly one of the most exciting and attracting one. Despite the fact that the metallic drug-eluting stents have significantly diminished the re-stenosis ratio, they have considerable limitations including the hypersensitivity reaction to the polymer that can cause local inflammation, the risk of neo-atherosclerotic lesion formation which can lead to late stent failure as well as the fact that they may preclude surgical revascularization and distort vessel physiology. Bioresorbable scaffolds overcome these limitations as they have the ability to dissolve after providing temporary scaffolding which safeguards vessel patency. In this article we review the recent developments in the field and provide an overview of the devices and the evidence that support their efficacy in the treatment of CAD. Currently 3 devices are CE marked and in clinical use. Additional 24 companies are developing these kind of coronary devices. Most frequently used material is PLLA followed by magnesium.

11 Review Status and potential clinical value of a transthoracic evaluation of the coronary arteries. 2016

Labombarda, Fabien / Castelnuovo, Samuela / Goularas, Dionysis / Sirtori, Cesare R. ·Department of Cardiology, CHU de Caen, Avenue cote de nacre, 14000, Caen, France. fabien.labombarda@gmail.com. · Center E. Grossi Paoletti, University of Milano and Dyslipidemia Center, Niguarda Hospital, Milan, Italy. samuela.castelnuovo@ospedaleniguarda.it. · Department of Computer Engineering, Yeditepe University, Istanbul, Turkey. goularas@cse.yeditepe.edu.tr. · Center E. Grossi Paoletti, University of Milano and Dyslipidemia Center, Niguarda Hospital, Milan, Italy. cesare.sirtori@icloud.com. ·Cardiovasc Ultrasound · Pubmed #26787070.

ABSTRACT: The growing need for coronary evaluation has raised interest in non-radioactive, non-invasive monitoring systems. In particular, radiation exposure during coronary investigations has been shown to be a possible cause of an enhanced risk of secondary tumors. Literature search has indicated that transthoracic echocardiography (TTE) has been widely applied to coronary arteries up to 2003, following which the lack of adequate equipment and the increased availability of invasive diagnostics, has reduced interest in this low cost, low-risk technology. The more recent availability of newer, more sensitive machines, allows evaluation of a larger number of arterial trees, including the aorta in newborns, the prenatal aortic intima-media thickness, as well as the detection of coronary artery anomalies in the adult. Improved technology for this highly operator sensitive technique may thus predict a possible evolution toward the clinical diagnostics of coronary disease and, eventually, also of the progression/regression of disease. We sought to evaluate the present status of this seldom quoted non-invasive technology.

12 Review Role of Micronutrients on Subclinical Atherosclerosis Micronutrients in Subclinical Atherosclerosis. 2016

Kocyigit, Duygu / Gurses, Kadri Murat / Yalcin, Muhammed Ulvi / Tokgozoglu, Lale. ·Department of Cardiology Hacettepe University Faculty of Medicine, 06100 Sihhiye Ankara, Turkey. kocyigitduygu@yahoo.com. ·Curr Pharm Des · Pubmed #26561073.

ABSTRACT: Atherosclerotic cardiovascular disease (CVD) leading to coronary heart disease is the leading cause of morbidity and mortality in the world. Nutrition is one of the key factors in the etiology of atherosclerosis. Micronutrient supplements are widely used to prevent many chronic diseases including atherosclerosis. However, scientific evidence regarding this issue is still insufficient and current data on the association of dietary micronutrients and CVD risk is contradictory. Most of the randomized studies have failed to demonstrate beneficial effects of micronutrient supplementation on markers of subclinical atherosclerosis. In this review, role of each micronutrient on subclinical atherosclerosis will be evaluated thoroughly.

13 Review How do we measure epicardial adipose tissue thickness by transthoracic echocardiography? 2015

Eroğlu, Serpil. ·Department of Cardiology, Faculty of Medicine, Başkent University; Ankara-Turkey. serpileroglu@gmail.com. ·Anatol J Cardiol · Pubmed #25993714.

ABSTRACT: Epicardial adipose tissue (EAT) is a component of the visceral adiposity located between the heart and pericardium. It is associated with certain diseases, such as metabolic syndrome, coronary artery disease, and hypertension. Therefore, measurement of EAT thickness has recently gained importance. Examination by transthoracic echocardiography for measuring EAT thickness is preferable because of easy availability and low cost. The present review focuses on the method of measuring EAT thickness by transthoracic echocardiography as well as the issues of concern.

14 Review Validity of Vascular Calcification as a Screening Tool and as a Surrogate End Point in Clinical Research. 2015

Zoccali, Carmine / Bolignano, Davide / D'Arrigo, Graziella / Dekker, Friedo W / Fliser, Danilo / Heine, Gunnar H / Jager, Kitty J / Kanbay, Mehmet / Mallamaci, Francesca / Massy, Ziad / Ortiz, Alberto / Parati, Gianfranco / Rossignol, Patrick / Tripepi, Giovanni / Vanholder, Raymond / Wiecek, Andrzej / London, Gerard / Anonymous7230829. ·From the CNR-IFC Pathophysiology of Renal Diseases and Hypertension Unit, Reggio Calabria, Italy (C.Z., D.B., G.D'A., F.M., G.T.) · Department of Clinical Epidemiology, Leiden University Medical Center, Leiden, The Netherlands (F.W.D.) · Department of Internal Medicine IV, Saarland University Medical Centre, Homburg/Saar, Germany (D.F., G.H.H.) · Department of Medical Informatics, Academic Medical Center, European Renal Association-European Dialysis and Transplant Association (ERA-EDTA) Registry, University of Amsterdam, Amsterdam, The Netherlands (K.J.J.) · Division of Nephrology, Department of Medicine, Koc University School of Medicine, Istanbul, Turkey (M.K.) · Nephrology, Dialysis, and Transplantation Unit and CNR-IFC Clinical Epidemiology, Reggio Calabria, Italy (F.M.) · Paris Ile de France Ouest (UVSQ) University, Paris, France (Z.M.) · Fundación Jiménez Díaz, Universidad Autónoma de Madrid, Fundación Renal Iñigo Alvarez de Toledo, Madrid, Spain (A.O.) · Department of Cardiovascular, Neural, and Metabolic Sciences, S. Luca Hospital, Istituto Auxologico Italiano & University of Milan-Bicocca, Milan, Italy (G.P.) · INSERM, Centre d'Investigations Cliniques-Plurithématique 1433, INSERM U1116, Nancy, France (P.R.) · Département de Cardiologie, CHU Nancy, Institut Lorrain du Cœur et des Vaisseaux, Vandoeuvre lès Nancy, France (P.R.) · Université de Lorraine, Nancy, France (P.R.) · INI-CRCT (Cardiovascular and Renal Clinical Trialists), French-Clinical Research Infrastructure Network (F-CRIN), Nancy, France (P.R.) · Division of Nephrology, Department of Internal Medicine, Ghent University Hospital, University Hospital Gent, Ghent, Belgium (R.V.) · Department of Nephrology, Endocrinology and Metabolic Diseases, Medical University of Silesia, Katowice, Poland (A.W.) · and INSERM U970, Hopital Européen Georges Pompidou, Paris, France (G.L.). ·Hypertension · Pubmed #25966492.

ABSTRACT: -- No abstract --

15 Review Bypass grafting versus percutaneous intervention in multivessel coronary disease: the current state. 2015

Sipahi, Ilke. ·Department of Cardiology, Acibadem University Medical School, Acibadem Maslak Hospital, Buyukdere Cad 40, 34457, Istanbul, Turkey, ilkesipahi@gmail.com. ·Curr Cardiol Rep · Pubmed #25618303.

ABSTRACT: Whether stenting or coronary artery bypass grafting (CABG) is the best revascularization strategy in patients with multivessel disease has been a heavily debated controversy. The trials comparing the two methods were unfortunately underpowered for mortality. Moreover, results of clinical trials appeared to contradict with each other. Because CABG is unequivocally a more cumbersome method, stenting became commonly preferred in the absence of evidence for mortality difference. Meta-analysis is a powerful tool, especially when several high-quality randomized trials are available on the same issue. In these instances, meta-analyses can overcome the power limitation of the individual trials. Our recent meta-analysis reveals that, as compared to stenting, CABG leads to unequivocal reductions in mortality and myocardial infarctions in patients with multivessel disease. These benefits are seen regardless of whether patients are diabetic or not and also do not depend on whether bare-metal or drug-eluting stents are used.

16 Review Noninvasive cardiac imaging for the diagnosis of coronary artery disease in women. 2014

Canpolat, Uğur / Özer, Necla. ·Cardiology Clinic, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey. neclaozer@hotmail.com. ·Anadolu Kardiyol Derg · Pubmed #25341480.

ABSTRACT: Cardiovascular diseases are the foremost cause of morbidity and mortality for both genders worldwide. Appropriate diagnostic tests with increased accuracy and safety provide the decisive relationship between diagnosis and treatment of coronary artery disease (CAD). However, it has been known that women at risk for occurrence of CAD are less often conducted for the proper diagnostic tests compared to men. Many noninvasive diagnostic modalities (exercise/stress electrocardiogram, echocardiography, nuclear imaging, magnetic resonance imaging and coronary computerized tomography) are available for this purpose in the women. In this review, we present the current data on the role of both conventional and modern noninvasive diagnostic tests in the assessment of women with CAD suspicion.

17 Review Role of biomaterials in prevention of in-stent restenosis. 2014

Laçin, Nelisa T / Utkan, Guldem G. ·Advanced Technology Education, Research and Application Center, Mersin University, 33343, Mersin, Turkey. ·J Biomed Mater Res B Appl Biomater · Pubmed #24307479.

ABSTRACT: Coronary balloon angioplasty and coronary stenting are the procedures used in healing coronary artery disease. However, injury of arteries during angioplasty and stenting causes cell stimulations in tissue. Cell movement and thrombosis lead to re-narrowing of widened vessel called restenosis. Several new types of carriers and technology have been developed to suppress and/or prevent restenosis. Authors review the polymeric materials featured in drug/gene carrier systems, nanovehicles, and stent coating materials against restenosis.

18 Review Coronary artery bypass grafting vs percutaneous coronary intervention and long-term mortality and morbidity in multivessel disease: meta-analysis of randomized clinical trials of the arterial grafting and stenting era. 2014

Sipahi, Ilke / Akay, M Hakan / Dagdelen, Sinan / Blitz, Arie / Alhan, Cem. ·Department of Cardiology, Acibadem University Medical School, Istanbul, Turkey2Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio. · Department of Cardiovascular Surgery, Acibadem University Medical School, Istanbul, Turkey. · Department of Cardiology, Acibadem University Medical School, Istanbul, Turkey. · Harrington Heart and Vascular Institute, University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio. ·JAMA Intern Med · Pubmed #24296767.

ABSTRACT: IMPORTANCE: Recent trials of percutaneous coronary intervention (PCI) vs coronary artery bypass grafting (CABG) for multivessel disease were not designed to detect a difference in mortality and therefore were underpowered for this outcome. Consequently, the comparative effects of these 2 revascularization methods on long-term mortality are still unclear. In the absence of solid evidence for mortality difference, PCI is oftentimes preferred over CABG in these patients, given its less invasive nature. OBJECTIVES: To determine the comparative effects of CABG vs PCI on long-term mortality and morbidity by performing a meta-analysis of all randomized clinical trials of the current era that compared the 2 treatment techniques in patients with multivessel disease. DATA SOURCES: A systematic literature search was conducted for all randomized clinical trials directly comparing CABG with PCI. STUDY SELECTION: To reflect current practice, we included randomized trials with 1 or more arterial grafts used in at least 90%, and 1 or more stents used in at least 70% of the cases that reported outcomes in patients with multivessel disease. DATA EXTRACTION: Numbers of events at the longest possible follow-up and sample sizes were extracted. DATA SYNTHESIS: A total of 6 randomized trials enrolling a total of 6055 patients were included, with a weighted average follow-up of 4.1 years. There was a significant reduction in total mortality with CABG compared with PCI (I2 = 0%; risk ratio [RR], 0.73 [95% CI, 0.62-0.86]) (P < .001). There were also significant reductions in myocardial infarction (I2 = 8.02%; RR, 0.58 [95% CI, 0.48-0.72]) (P < .001) and repeat revascularization (I2 = 75.6%; RR, 0.29 [95% CI, 0.21-0.41]) (P < .001) with CABG. There was a trend toward excess strokes with CABG (I2 = 24.9%; RR, 1.36 [95% CI, 0.99-1.86]), but this was not statistically significant (P = .06). For reduction in total mortality, there was no heterogeneity between trials that were limited to and not limited to patients with diabetes or whether stents were drug eluting or not. Owing to lack of individual patient-level data, additional subgroup analyses could not be performed. CONCLUSIONS AND RELEVANCE: In patients with multivessel coronary disease, compared with PCI, CABG leads to an unequivocal reduction in long-term mortality and myocardial infarctions and to reductions in repeat revascularizations, regardless of whether patients are diabetic or not. These findings have implications for management of such patients.

19 Review Pregnancy-associated myocardial infarction : case report and review of the literature. 2014

Bezgin, T / Geçmen, Ç / Erden, I / Esen, A M. ·Cardiology Clinic, Kartal Koşuyolu Heart&Research Hospital, Denizer Cad. Cevizli, 34846, Kartal-İstanbul, Turkey, bezgintahir3@yahoo.com. ·Herz · Pubmed #23873007.

ABSTRACT: Acute myocardial infarction (AMI) is a rare, but possibly catastrophic event during pregnancy, delivery, or puerperium, leading to a high mortality rate. It has different pathogenic mechanisms, such as atherosclerosis, vasospasm, thrombosis, and coronary dissection. Although MI has been reported in pregnant women at all stages of pregnancy and postpartum, it occurs more commonly in the third trimester. Pregnancy-associated MI most commonly involves the anterior wall. Pregnancy itself is an independent risk factor for MI, conferring a fourfold higher risk than that of nonpregnant women matched for age. We report the case of a 27-year-old primigravida at 30 weeks' gestation presenting with anterior MI, secondary to severe stenosis of the left anterior descending coronary artery, treated with emergency percutaneous coronary intervention.

20 Review Psoriasis and atherosclerosis: Is there a need for novel biomarkers assessing cardiovascular risk? 2014

Sunbul, Murat / Agirbasli, Mehmet. ·Yesilbahar Sok. 68/14 Goztepe 34726 Istanbul Turkey. magirbasli@gmail.com. ·Curr Pharm Des · Pubmed #23565636.

ABSTRACT: Epidemiological studies indicate increased mortality rates in cohorts of patients with psoriatic arthritis (PsA). Psoriasis is associated with an enhanced cardiovascular risk. The excess mortality in psoriasis and PsA is predominantly due to coronary artery disease. The aim of this review is to overview the biomarkers and/or mediators of increased cardiovascular risk in patients with psoriasis and PsA. We searched through Medline/PubMed to retrieve sources on cardiovascular disease (CVD), related risk factors and inflammatory markers in psoriasis and PsA. We analyzed the relationship between psoriasis and novel vascular biomarkers with potential use for preventive studies. Studies underline the importance of considering psoriatic patients as a high-risk population in terms of CVD. Novel biomarkers of inflammation, thrombosis, oxidative stress and atherosclerosis can provide risk stratification and strategies for early detection and treatment of CVD in patients with psoriasis. A better understanding of the association between psoriasis and vascular risk can help the clinician to manage the increased morbidity and mortality related to CVD.

21 Review Pseudoaneurysm originating from left ventricle aneurysm: an autopsy case and review of literature. 2013

Dogan, Kamil Hakan / Demirci, Serafettin / Tavli, Lema / Buken, Bora. ·Department of Forensic Medicine, Faculty of Medicine, Selcuk University, Aleaddin Keykubat Campus, Selcuklu, 42075 Konya, Turkey. Electronic address: drhakan2000@gmail.com. ·J Forensic Leg Med · Pubmed #24237794.

ABSTRACT: Rupture of the free wall of the left ventricle is a catastrophic complication of acute myocardial infarction. Rarely, free wall rupture is contained by overlying adherent pericardium, producing a pseudoaneurysm of the left ventricle. In this report, a case of a left ventricular pseudoaneurysm due to a previous myocardial infarction is described. A 55-year-old woman had a severe chest pain 11 months prior to death. No cardiac investigation was performed. Three days prior to death, she suffered from fatigue and weakness, and had a witnessed sudden cardiac death. At autopsy, a 8.5 × 10 × 8 cm pseudoaneurysm of the left ventricle was found. There was severe coronary artery atherosclerosis. There were extensive adhesions between pericardium and pseudoaneurysm wall. The cause of death was attributed to heart failure and resulting arrhythmia. The case illustrates the rare event of left ventricular pseudoaneurysm first diagnosed at forensic autopsy.

22 Review Epicardial adipose tissue: a review of physiology, pathophysiology, and clinical applications. 2013

Şengül, Cihan / Özveren, Olcay. ·Division of Cardiology, Gaziosmanpaşa Hospital, İstanbul, Turkey. drcsengul@yahoo.com ·Anadolu Kardiyol Derg · Pubmed #23395709.

ABSTRACT: Visceral fat tissue is an important predictor of cardio-metabolic diseases, carrying more risk than general fat accumulation. Epicardial fat, a particular form of visceral fat deposited around the heart, is considered an important cardiovascular risk predictor, in view of producing and releasing several adipo-cytokines. There is growing evidence about the physiological and metabolic importance of epicardial fat. Epicardial fat thickness and volume have both strong correlation between obesity, impaired fasting glucose, insulin resistance, metabolic syndrome, hypertension, diabetes mellitus, and atherosclerosis. Epicardial fat can be assessed by transthoracic echocardiography, cardiac magnetic resonance imaging, and computed tomography. In this article, we reviewed the anatomy, physiology, function, and the methods of assessment of epicardial fat tissue. We also have tried to discuss its relationship to metabolic syndrome and coronary atherosclerosis in the lights of recent findings.

23 Review [Prediabetes, becoming the equivalent of coronary artery disease]. 2012

Ceyhan, Köksal / Altunkaş, Fatih. ·Department of Cardiology, Gaziospanpaşa University Faculty of Medicine, Tokat, Turkey. kceyhan09@yahoo.com. ·Turk Kardiyol Dern Ars · Pubmed #23187443.

ABSTRACT: Prediabetes refers to a state where blood glucose levels are higher than normal, but not high enough to meet the diagnostic criteria for diabetes mellitus. Similar to the worldwide trend, data derived from large studies has shown an increasing trend in the prevalence of prediabetes in Turkey. According to the Centers for Disease Control and Prevention data, 79 million individuals in the United States have prediabetes. This implies a large population worldwide is at risk of developing diabetes in the near future. In addition to its strong association with the development of diabetes, prediabetes itself represents an increased risk of developing cardiovascular disease and its complications. This review will focus on definition, detection, association with cardiovascular disease and treatment of prediabetes.

24 Review Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases. 2012

Taşçı, İlker / Kabul, Hasan Kutsi / Aydoğdu, Aydoğan. ·Department of Internal Medicine, Gülhane School of Medicine, Ankara-Turkey. itasci@gata.edu.tr ·Anadolu Kardiyol Derg · Pubmed #22989797.

ABSTRACT: Important advances in our understanding of the relationships between adipose tissue derived peptides, namely adipokines, and their effects on cardiovascular functions have been achieved in recent years. Growing knowledge of adipokine biology is revealing the complexity of these proteins. Adipose tissue releases some other proteins called neurotrophins that are mainly active in central and peripheral nervous system. However, secretion and activity of these hormones are not only limited to neuronal cells and tissues, but they also take part in adipose tissue development, energy metabolism, glucose utilization, insulin sensitivity, inflammation, lipoprotein synthesis, and atherosclerosis. In this review, we describe the most recent advances in the functions of brain derived nerve growth factor (BDNF), a major type of neurotrophins, focusing primarily on cardiovascular and metabolic diseases.

25 Review [Coronary artery disease from a perspective of genomic risk score, ethical approaches and suggestions]. 2012

Ağırbaşlı, Deniz / Ülman, Yeşim Işıl. ·Acıbadem Üniversitesi Tıp Fakültesi, Tıbbi Biyoloji Anabilim Dalı İstanbul-Turkey. deniz.agirbasli@acibadem.edu.tr ·Anadolu Kardiyol Derg · Pubmed #22306571.

ABSTRACT: As a leading cause of mortality, coronary artery disease is on the focus of genetic research as a complex trait. Although predictive genetic testing for cardiovascular diseases is on the counter, it is still hard to aggregate information from multiple genetic variants, environmental factors and family history into a single score. Every susceptibility allele provides small contribution to disease formation. Biomarkers play a role in various metabolic pathways. Genetic information and data depend heavily on probabilities. This should be clearly explained by genetic counselor to the patient and relatives who are looking for certain answers. Presence of susceptibility alleles can be a source of anxiety and it may result as a reduced self-confidence in ability to change health behavior. Complex diseases set a new stage to study novel techniques that can elucidate interactions among genetic, environmental and ethnic factors. The cookbook approach to treat a complex disease can often be misleading. Future studies may provide personalized information, which can improve the outcome of standardized treatments. As knowing one's own genetic risk is becoming a task for the responsible individual, it surely will add new challenges to ethical framework. Publicly marketing genetic tests for complex diseases raises ethical concerns. To avoid discriminatory use of genetic information; genetic risk scoring, therapeutic process, ethical policies must have a multifaceted progress. In this review, we summarized the attempts to resolve ethical issues related to genetic testing in complex diseases to resolve patient autonomy with individual responsibility and to aim the patient beneficence and confidentiality.