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Coronary Artery Disease: HELP
Articles from Erasmus University Rotterdam
Based on 738 articles published since 2008
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These are the 738 published articles about Coronary Artery Disease that originated from Erasmus University Rotterdam during 2008-2019.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14 · 15 · 16 · 17 · 18 · 19 · 20
1 Guideline Perspectives on the 2014 ESC/EACTS Guidelines on Myocardial Revascularization : Fifty Years of Revascularization: Where Are We and Where Are We Heading? 2015

Costa, Francesco / Ariotti, Sara / Valgimigli, Marco / Kolh, Philippe / Windecker, Stephan / Anonymous4360830. ·Thoraxcenter, Erasmus Medical Center, 3015 CE, Rotterdam, The Netherlands. ·J Cardiovasc Transl Res · Pubmed #25986910.

ABSTRACT: The joint European Society of Cardiology and European Association of Cardio-Thoracic Surgery (ESC/EACTS) guidelines on myocardial revascularization collect and summarize the evidence regarding decision-making, diagnostics, and therapeutics in various clinical scenarios of coronary artery disease, including elective, urgent, and emergency settings. The 2014 document updates and extends the effort started in 2010, year of the first edition of these guidelines. Importantly, this latest edition provides a systematic review of all randomized clinical trials performed since 1980, comparing different strategies of myocardial revascularization, including coronary artery bypass graft (CABG), balloon angioplasty, percutaneous coronary intervention (PCI) with bare-metal stents (BMS) and first- and second-generation drug-eluting stents (DES). This review aims to highlight the most relevant novelties introduced by the 2014 edition of the ESC/EACTS myocardial revascularization guidelines as compared with the previous edition and to describe similarities and differences with the American societies' guidelines.

2 Guideline Tissue characterisation using intravascular radiofrequency data analysis: recommendations for acquisition, analysis, interpretation and reporting. 2009

García-García, Héctor M / Mintz, Gary S / Lerman, Amir / Vince, D Geoffrey / Margolis, M Paulina / van Es, Gerrit-Anne / Morel, Marie-Angèle M / Nair, Anuja / Virmani, Renu / Burke, Allen P / Stone, Gregg W / Serruys, Patrick W. ·Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands. ·EuroIntervention · Pubmed #20449928.

ABSTRACT: This document suggests standards for the acquisition, measurement, and reporting of radiofrequency data analysis (virtual histology - VH) intravascular ultrasound (IVUS) studies. Readers should view this document as the authors' best attempt in an area of rapidly evolving investigation, an area where rigorous evidence is not yet available or widely accepted. Nevertheless, this document is based on known pathologic data as well as previously reported imaging data; where practical, this data is summarised in the current document, a document which will also include recommendations for future evolution of the technology.

3 Guideline Meeting report ESC forum on drug eluting stents, European Heart House, Nice, 27-28 September 2007. 2009

Daemen, Joost / Simoons, Maarten L / Wijns, William / Bagust, Adrian / Bos, Gert / Bowen, James M / Braunwald, Eugene / Camenzind, Edoardo / Chevaliers, Bernard / DiMario, Carlo / Fajadeto, Jean / Gitt, Anselm / Guagliumi, Giulio / Hillege, Hans L / James, Stefan / Jüni, Peter / Kastrati, Adnan / Kloth, Sabine / Kristensen, Steen D / Krucoff, Mitchell / Legrand, Victor / Pfisterer, Matthias / Rothman, Martin / Serruys, Patrick W / Silber, Sigmund / Steg, Philippe G / Tariah, Ibrahim / Wallentin, Lars / Windecker, Stephan W / Aimonetti, A / Allocco, D / Berenger, M / Boam, A / Calle, J P / Campo, G / Carlier, S / de Schepper, J / Di Bisceglie, G / Dobbels, H / Farb, A / Ghislain, J C / Hellbardt, S / ten Hoedt, R / Isaia, C / de Jong, P / Lekehal, M / LeNarz, L / Mhullain, F Ni / Nagai, H / Patteet, A / Paunovic, D / Potgieter, A / Purdy, I / Raveau-Landon, C / Ternstrom, S / Van Wuytswinkel, J / Waliszewski, M / Anonymous830624. ·Thoraxcenter, Erasmus MC, Rotterdam, The Netherlands. ·EuroIntervention · Pubmed #19284063.

ABSTRACT: -- No abstract --

4 Editorial Xanthomas and atheromas. 2017

Sijbrands, Eric J. ·Department of Internal Medicine, Erasmus Medical Center, Rotterdam, The Netherlands. Electronic address: e.sijbrands@erasmusmc.nl. ·Atherosclerosis · Pubmed #28606368.

ABSTRACT: -- No abstract --

5 Editorial Management of coronary artery disease with cardiac CT beyond gatekeeping. 2017

Cademartiri, Filippo / Nistri, Stefano / Tarantini, Giuseppe / Maffei, Erica. ·Department of Radiology & Research Center, Montreal Heart Institute/Universitè de Montreal, Montreal, Quebec, Canada. · Department of Radiology, Erasmus Medical Center University, Rotterdam, The Netherlands. · Cardiology Service, CMSR- Veneto Medica, Altavilla Vicentina, Italy. · Department of Cardiology, University of Padua, Padua, Italy. ·Heart · Pubmed #28446549.

ABSTRACT: -- No abstract --

6 Editorial Clinical Value of Coronary Computed Tomographic Angiography in Patients With Stable Angina. 2016

Nieman, Koen. ·From the Departments of Cardiology and Radiology, Erasmus University Medical Center, Rotterdam, The Netherlands. ·Circ Cardiovasc Imaging · Pubmed #27072304.

ABSTRACT: -- No abstract --

7 Editorial Balancing idealism with realism to safeguard the welfare of patients: The importance of Heart Team led decision-making in patients with complex coronary artery disease. 2016

Farooq, Vasim / Di Mario, Carlo / Serruys, Patrick W. ·Institute of Cardiovascular Sciences, Manchester Academic Health Sciences Centre, University of Manchester and Manchester Heart Centre, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Trust, Manchester, United Kingdom. Electronic address: vasimfarooq@icloud.com. · NIHR Cardiovascular BRU, Royal Brompton & Harefield NHS Foundation Trust and Imperial College London, London, United Kingdom. · Emeritus Professor of Medicine with a Chair in Interventional Cardiology at the Erasmus University, Rotterdam, The Netherlands; International Centre for Circulatory Health, NHLI, Imperial College, London, United Kingdom. ·Indian Heart J · Pubmed #26896257.

ABSTRACT: -- No abstract --

8 Editorial Cardiac CT for the detection of vulnerable plaque. 2016

Cademartiri, Filippo / Maffei, Erica. ·Department of Radiology, Montreal Heart Institute, Universitè de Montreal, Montreal, Canada Department of Radiology, Erasmus Medical Center University, Rotterdam, The Netherlands filippocademartiri@gmail.com. · Centre de Recherche, Montreal Heart Institute, Universitè de Montreal, Montreal, Canada. ·Eur Heart J Cardiovasc Imaging · Pubmed #26628618.

ABSTRACT: -- No abstract --

9 Editorial Doing better in more complex patients: leading the way for QUIP. 2016

Osnabrugge, Ruben L / Kappetein, A Pieter / Head, Stuart J / Kolh, Philippe. ·Erasmus University Medical Center, Rotterdam, Netherlands. · Department of Cardiovascular Surgery, University Hospital (CHU, ULg) of Liège, Liège, Belgium philippe.kolh@chu.ulg.ac.be. ·Eur J Cardiothorac Surg · Pubmed #26242898.

ABSTRACT: -- No abstract --

10 Editorial Snowshoe Versus Ice Skate for Scaffolding of Disrupted Vessel Wall. 2015

Serruys, Patrick W / Suwannasom, Pannipa / Nakatani, Shimpei / Onuma, Yoshinobu. ·International Center for Circulatory Health, National Heart and Lung Institute, Imperial College London, London, United Kingdom. Electronic address: patrick.w.j.c.serruys@gmail.com. · Department of Interventional Cardiology, Thoraxcenter, Erasmus Medical Center, Rotterdam, the Netherlands. ·JACC Cardiovasc Interv · Pubmed #26088509.

ABSTRACT: -- No abstract --

11 Editorial Cardiac CT in asymptomatic diabetes mellitus: role of non-invasive atherosclerosis imaging in high-risk asymptomatic individuals. 2015

Cademartiri, Filippo / Maffei, Erica / Nistri, Stefano / Leipsic, Jonathon. ·Department of Radiology, Erasmus Medical Center University, Rotterdam, The Netherlands filippocademartiri@gmail.com. · Department of Radiology, Giovanni XXIII Clinic, Monastier di Treviso, Italy. · Department of Cardiology, CMSR, Altavilla Vicentina, Italy. · Department of Radiology, University of British Columbia, Vancouver, Canada. ·Eur Heart J Cardiovasc Imaging · Pubmed #26041310.

ABSTRACT: -- No abstract --

12 Editorial Duration of dual antiplatelet therapy after drug-eluting stent implantation: will we ever reach a consensus? 2015

Valgimigli, Marco / Ariotti, Sara / Costa, Francesco. ·Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands m.valgimigli@erasmusmc.nl. · Thoraxcenter, Erasmus Medical Center, Rotterdam, The Netherlands. ·Eur Heart J · Pubmed #25761893.

ABSTRACT: -- No abstract --

13 Editorial Evolve or perish for coronary calcium imaging. 2015

Nieman, Koen. ·Department of Cardiology, Erasmus MC, Room Bd 116, PO Box 2040, 3000 CA Rotterdam, The Netherlands Department of Radiology, Erasmus MC, Room Bd 116, PO Box 2040, 3000 CA Rotterdam, The Netherlands k.nieman@erasmusmc.nl. ·Eur Heart J Cardiovasc Imaging · Pubmed #25381301.

ABSTRACT: -- No abstract --

14 Editorial Women are from SATURN and men are from an ASTEROID: deciphering the REVERSAL of coronary atheroma. 2014

Garcia-Garcia, Hector M / Campos, Carlos M / Serruys, Patrick W. ·Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, the Netherlands. Electronic address: hect2701@gmail.com. · Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, the Netherlands; Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil. · Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, the Netherlands. ·JACC Cardiovasc Imaging · Pubmed #25323164.

ABSTRACT: -- No abstract --

15 Editorial Coronary bifurcations: still the touchstone of drug-eluting stents and bioresorbable vascular scaffolds? 2014

von Birgelen, Clemens / van Houwelingen, K Gert / Lam, Ming Kai. ·Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, The Netherlands; Department of Health Technology and Services Research, MIRA - Institute for Biomedical Technology and Technical Medicine, University of Twente, Enschede, The Netherlands. Electronic address: c.vonbirgelen@mst.nl. · Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Enschede, The Netherlands. ·Rev Esp Cardiol (Engl Ed) · Pubmed #25262123.

ABSTRACT: -- No abstract --

16 Editorial Precise vessel sizing: a trivial but crucial issue during left main stenting. 2014

Campos, Carlos M / Lemos, Pedro A. ·Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands; Department of Interventional Cardiology, Heart Institute (InCor), University of São Paulo, Brazil. ·Catheter Cardiovasc Interv · Pubmed #25142420.

ABSTRACT: -- No abstract --

17 Editorial Bioresorbable vascular scaffolds: novel devices, novel interpretations, and novel interventions strategies. 2014

Campos, Carlos M / Lemos, Pedro A. ·Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands, Heart Institute (InCor, University of São Paulo Medical Schoo, Sao Paulo, Brazil; Department of Interventional Cardiology, Heart Institute (InCor), University of São Paulo Medical School, Sao Paulo, Brazil. ·Catheter Cardiovasc Interv · Pubmed #24975261.

ABSTRACT: -- No abstract --

18 Editorial Coronary atherosclerosis: the predictor of cardiovascular events. 2014

Cademartiri, Filippo / Arcadi, Teresa / Tarantini, Giuseppe / Maffei, Erica. ·Department of Radiology, Erasmus Medical Center, Rotterdam, The Netherlands. ·Cardiology · Pubmed #24903701.

ABSTRACT: -- No abstract --

19 Editorial Standing on solid ground?: Reassessing the role of incomplete strut apposition in drug-eluting stents. 2014

Karanasos, Antonios / Regar, Evelyn. ·From the Department of Interventional Cardiology, Thoraxcenter, Erasmus University Medical Center, Rotterdam, The Netherlands. ·Circ Cardiovasc Interv · Pubmed #24550529.

ABSTRACT: -- No abstract --

20 Editorial Complex coronary artery disease: would outcomes from the SYNTAX (synergy between percutaneous coronary intervention with taxus and cardiac surgery) trial have differed with newer-generation drug-eluting stents? 2013

Farooq, Vasim / Serruys, Patrick W. ·Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, the Netherlands. ·JACC Cardiovasc Interv · Pubmed #24156963.

ABSTRACT: -- No abstract --

21 Editorial Residual SYNTAX score for left main intervention: Are we really ready to predict the future? 2013

Campos, Carlos A M / Lemos, Pedro A. ·Department of Interventional Cardiology, Erasmus University Medical Centre, Thoraxcenter, Rotterdam, The Netherlands. ·Catheter Cardiovasc Interv · Pubmed #24038972.

ABSTRACT: -- No abstract --

22 Editorial Ultrasound and light: friend or foe? On the role of intravascular ultrasound in the era of optical coherence tomography. 2011

Huisman, Jennifer / Hartmann, Marc / von Birgelen, Clemens. ·Department of Cardiology, Thoraxcentrum Twente, Medisch Spectrum Twente, Haaksbergerstraat 55, 7513 ER Enschede, The Netherlands. ·Int J Cardiovasc Imaging · Pubmed #21337025.

ABSTRACT: More than 20 years after its introduction, intravascular ultrasound (IVUS) has outlived many other intracoronary techniques. IVUS was useful to solve many interventional problems and assisted us in understanding the dynamics of atherosclerosis. It serves as an established imaging endpoint in large progression-regression trial and as an important workhorse in many catheterization laboratories. Nowadays, increasingly complex lesions are treated with drug-eluting stents. The application of IVUS during such interventions can be very useful. Recently, optical coherence tomography (OCT), a light-based imaging technique, has entered the clinical arena. The "omnipresence" of OCT during scientific sessions and live courses with PCI may raise in many the question: Does IVUS have a future in the "era of OCT"? Three review articles, highlighted by this editorial, demonstrate the broad spectrum of current IVUS applications and underline the significant role of IVUS during the last two decades. OCT, the much younger technique, still has to prove its value. Yet OCT is likely to take over some of the current indications of IVUS as a research tool. In addition, OCT is currently gaining clinical significance for stent optimization during complex interventional procedures. Nevertheless, there is little doubt that IVUS still has a major role in studies on coronary atherosclerosis and for guidance of coronary stenting. Thus, ultrasound and light--are they friend or foe? In fact, both methods are good in their own rights. They are complementary rather than competitive. Moreover, in combination, at least for certain indications, they could be even better.

23 Review Percutaneous coronary intervention or coronary artery bypass graft in left main coronary artery disease: a comprehensive meta-analysis of adjusted observational studies and randomized controlled trials. 2018

Bertaina, Maurizio / De Filippo, Ovidio / Iannaccone, Mario / Colombo, Antonio / Stone, Gregg / Serruys, Patrick / Mancone, Massimo / Omedè, Pierluigi / Conrotto, Federico / Pennone, Mauro / Kimura, Takeshi / Kawamoto, Hiroyoshi / Zoccai, Giuseppe Biondi / Sheiban, Imad / Templin, Christian / Benedetto, Umberto / Cavalcante, Rafael / D'Amico, Maurizio / Gaudino, Mario / Moretti, Claudio / Gaita, Fiorenzo / D'Ascenzo, Fabrizio. ·Division of Cardiology, Città Della Salute e della Scienza, Molinette Hospital, Turin. · Interventional Cardiology, Cardio-Thoracic-Vascular Department, San Raffaele Scientific Institute, Milan, Italy. · Cardiovascular Research and Education Columbia University Medical Center, Presbyterian Hospital, New York, USA. · Department of Interventional Cardiology, Erasmus University Medical Center, Rotterdam, the Netherlands. · Department of Cardiovascular, Respiratory, Nephrology, Anesthesiology and Geriatric Sciences, University 'La Sapienza' of Rome, Rome, Italy. · Department of Cardiovascular Medicine, Kyoto University, Japan. · Department of Medico-Surgical Sciences and Biotechnologies, Sapienza University of Rome, Latina. · Department of AngioCardioNeurology, IRCCS Neuromed, Pozzilli. · Cardiology Department, Pederzoli Hospital, Verona, Italy. · University Heart Center, Department of Cardiology, University Hospital Zurich, Zurich, Switzerland. · Bristol Heart Institute, University of Bristol, School of Clinical Sciences, Bristol, United Kingdom. · Department of Cardiothoracic Surgery, Weill Cornell Medical College, New York, New York, USA. ·J Cardiovasc Med (Hagerstown) · Pubmed #30095584.

ABSTRACT: BACKGROUND: Treatment of patients with ULMCA (unprotected left main coronary artery disease) with percutaneous coronary intervention (PCI) has been compared with coronary artery bypass graft (CABG), without conclusive results. METHODS: All randomized controlled trials (RCTs) and observational studies with multivariate analysis comparing PCI and CABG for ULMCA were included. Major cardiovascular events (MACEs, composite of all-cause death, MI, definite or probable ST, target vessel revascularization and stroke) were the primary end points, whereas its single components were the secondary ones, along with stent thrombosis, graft occlusion and in-hospital death and stroke. Subgroup analyses were performed according to Syntax score. RESULTS: Six RCTs (4717 patients) and 20 observational studies with multivariate adjustment (14 597 patients) were included. After 5 (3-5.5) years, MACE rate was higher for PCI [odds ratio (OR) 1.10, 95% confidence interval (CI) 1.07-1.14], without difference in death, whereas more relevant risk of MI was because of observational studies. Coronary stenting increased risk of revascularization (OR 1.52; 95% CI 1.34-1.72). At meta-regression, performance of PCI was improved by use of intra-coronary imaging and worsened by first generation stents, whereas two arterial grafts increased benefit of CABG. For patients with Syntax score less than 22, MACE rates did not differ, whereas for higher values, CABG reduced MACE because of lower risk of revascularization. Incidence of graft occlusion was 3.24% (2.25-4.23), whereas 2.13% (1.28-2.98: all CI 95%) of patients experienced stent thrombosis. CONCLUSION: Surgical revascularization reduces risk of revascularization for ULMCA patients, especially for those with Syntax score greater than 22, with a higher risk of in-hospital death. Intra-coronary imaging and use of arterial grafts improved performance of revascularization strategies.

24 Review Imaging-guided pre-dilatation, stenting, post-dilatation: a protocolized approach highlighting the importance of intravascular imaging for implantation of bioresorbable scaffolds. 2018

Ali, Ziad A / Karimi Galougahi, Keyvan / Shlofmitz, Richard / Maehara, Akiko / Mintz, Gary S / Abizaid, Alexandre / Chamié, Daniel / Hill, Jonathan / Serruys, Patrick W / Onuma, Yoshinobu / Stone, Gregg W. ·a Clinical Trials Center, Cardiovascular Research Foundation , New York , NY , USA. · b Department of Cardiology , NewYork-Presbyterian Hospital/Columbia University Medical Center , New York , NY , USA. · c Department of Cardiology , St Francis Hospital , Roslyn , NY , USA. · d Department of Cardiology , Instituto Dante Pazzanese of Cardiology , São Paulo , Brazil. · e Department of Cardiology , Cardiovascular Research Center , São Paulo , Brazil. · f Department of Cardiology , King's College , London , UK. · g Imperial College of Science, Technology and Medicine , London , UK. · h Thoraxcenter, Erasmus Medical Center , Rotterdam , The Netherlands. ·Expert Rev Cardiovasc Ther · Pubmed #29732926.

ABSTRACT: INTRODUCTION: The advent of the fully bioresorbable vascular scaffold (BVS) is the latest step in a series of advancements in the design of intracoronary stents over the past few decades. The novelty of this technology is in providing temporary vessel scaffolding and local antiproliferative therapy to prevent neointimal hyperplasia after percutaneous coronary intervention followed by gradual resorption of the scaffold to restore the native vessel anatomy and physiology - a process termed vascular reparative therapy. Areas covered: The first generation of BVS has not been able to fully match the high benchmark in safety and efficacy set by contemporary metallic drug-eluting stents. These shortcomings of BVS may be due to factors related to the device itself, the complexity of the underlying lesion, or the implantation technique. Expert commentary: Here, how intravascular imaging may be used to minimize these shortcomings is described and moreover, an imaging-guided step-by-step approach for BVS implantation that integrates the recently described pre-dilatation, stenting, post-dilatation (PSP) strategy is explained.

25 Review Mortality after coronary artery bypass grafting versus percutaneous coronary intervention with stenting for coronary artery disease: a pooled analysis of individual patient data. 2018

Head, Stuart J / Milojevic, Milan / Daemen, Joost / Ahn, Jung-Min / Boersma, Eric / Christiansen, Evald H / Domanski, Michael J / Farkouh, Michael E / Flather, Marcus / Fuster, Valentin / Hlatky, Mark A / Holm, Niels R / Hueb, Whady A / Kamalesh, Masoor / Kim, Young-Hak / Mäkikallio, Timo / Mohr, Friedrich W / Papageorgiou, Grigorios / Park, Seung-Jung / Rodriguez, Alfredo E / Sabik, Joseph F / Stables, Rodney H / Stone, Gregg W / Serruys, Patrick W / Kappetein, Arie Pieter. ·Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands. Electronic address: s.head@erasmusmc.nl. · Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands. · Department of Cardiology, Erasmus University Medical Center, Rotterdam, Netherlands. · Department of Cardiology, University of Ulsan College of Medicine, Asan Medical Center, Seoul, South Korea. · Department of Cardiology, Aarhus University Hospital, Skejby, Aarhus, Denmark. · Icahn School of Medicine at Mount Sinai, New York, NY, USA; Peter Munk Cardiac Centre and the Heart and Stroke Richard Lewar Centre, University of Toronto, Toronto, ON, Canada. · Norwich Medical School University of East Anglia and Norfolk and Norwich University Hospital, Norwich, UK. · Icahn School of Medicine at Mount Sinai, New York, NY, USA. · Stanford University School of Medicine, Stanford, CA, USA. · Heart Institute (InCor), University of São Paulo Medical School, São Paulo, Brazil. · Richard L Roudebush VA Medical Center, Indianapolis, IN, USA. · Department of Cardiology, Oulu University Hospital, Oulu, Finland. · Department of Cardiac Surgery, Herzzentrum Universität Leipzig, Leipzig, Germany. · Department of Cardiothoracic Surgery, Erasmus University Medical Center, Rotterdam, Netherlands; Department of Biostatistics, Erasmus University Medical Center, Rotterdam, Netherlands. · Cardiac Unit, Otamendi Hospital, Buenos Aires, Argentina. · Department Surgery, University Hospitals Cleveland Medical Center, Cleveland, OH, USA. · Institute of Cardiovascular Medicine and Science, Liverpool Heart and Chest Hospital, Liverpool, UK. · Columbia University Medical Center and the Center for Clinical Trials, Cardiovascular Research Foundation, New York, NY, USA. · Imperial College London, London, UK. ·Lancet · Pubmed #29478841.

ABSTRACT: BACKGROUND: Numerous randomised trials have compared coronary artery bypass grafting (CABG) with percutaneous coronary intervention (PCI) for patients with coronary artery disease. However, no studies have been powered to detect a difference in mortality between the revascularisation strategies. METHODS: We did a systematic review up to July 19, 2017, to identify randomised clinical trials comparing CABG with PCI using stents. Eligible studies included patients with multivessel or left main coronary artery disease who did not present with acute myocardial infarction, did PCI with stents (bare-metal or drug-eluting), and had more than 1 year of follow-up for all-cause mortality. In a collaborative, pooled analysis of individual patient data from the identified trials, we estimated all-cause mortality up to 5 years using Kaplan-Meier analyses and compared PCI with CABG using a random-effects Cox proportional-hazards model stratified by trial. Consistency of treatment effect was explored in subgroup analyses, with subgroups defined according to baseline clinical and anatomical characteristics. FINDINGS: We included 11 randomised trials involving 11 518 patients selected by heart teams who were assigned to PCI (n=5753) or to CABG (n=5765). 976 patients died over a mean follow-up of 3·8 years (SD 1·4). Mean Synergy between PCI with Taxus and Cardiac Surgery (SYNTAX) score was 26·0 (SD 9·5), with 1798 (22·1%) of 8138 patients having a SYNTAX score of 33 or higher. 5 year all-cause mortality was 11·2% after PCI and 9·2% after CABG (hazard ratio [HR] 1·20, 95% CI 1·06-1·37; p=0·0038). 5 year all-cause mortality was significantly different between the interventions in patients with multivessel disease (11·5% after PCI vs 8·9% after CABG; HR 1·28, 95% CI 1·09-1·49; p=0·0019), including in those with diabetes (15·5% vs 10·0%; 1·48, 1·19-1·84; p=0·0004), but not in those without diabetes (8·7% vs 8·0%; 1·08, 0·86-1·36; p=0·49). SYNTAX score had a significant effect on the difference between the interventions in multivessel disease. 5 year all-cause mortality was similar between the interventions in patients with left main disease (10·7% after PCI vs 10·5% after CABG; 1·07, 0·87-1·33; p=0·52), regardless of diabetes status and SYNTAX score. INTERPRETATION: CABG had a mortality benefit over PCI in patients with multivessel disease, particularly those with diabetes and higher coronary complexity. No benefit for CABG over PCI was seen in patients with left main disease. Longer follow-up is needed to better define mortality differences between the revascularisation strategies. FUNDING: None.

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