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Coronary Artery Disease: HELP
Articles from University of British Columbia
Based on 189 articles published since 2008
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These are the 189 published articles about Coronary Artery Disease that originated from University of British Columbia during 2008-2019.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8
1 Guideline ACR Appropriateness Criteria 2018

Anonymous2701124 / Shah, Amar B / Kirsch, Jacobo / Bolen, Michael A / Batlle, Juan C / Brown, Richard K J / Eberhardt, Robert T / Hurwitz, Lynne M / Inacio, Joao R / Jin, Jill O / Krishnamurthy, Rajesh / Leipsic, Jonathon A / Rajiah, Prabhakar / Singh, Satinder P / White, Richard D / Zimmerman, Stefan L / Abbara, Suhny. ·Westchester Medical Center, Valhalla, New York. Electronic address: ashah27@northwell.edu. · Panel Chair, Cleveland Clinic Florida, Weston, Florida. · Panel Vice-Chair, Cleveland Clinic, Cleveland, Ohio. · Miami Cardiac and Vascular Institute and Baptist Health of South Florida, Miami, Florida. · University of Michigan Health System, Ann Arbor, Michigan. · Boston University School of Medicine, Boston, Massachusetts; American College of Cardiology. · Duke University Medical Center, Durham, North Carolina. · The Ottawa Hospital, University of Ottawa, Ottawa, Ontario, Canada. · Northwestern University Feinberg School of Medicine, Chicago, Illinois; American College of Physicians. · Nationwide Children's Hospital, Columbus, Ohio. · St. Paul's Hospital, Vancouver, British Columbia, Canada. · UT Southwestern Medical Center, Dallas, Texas. · University of Alabama at Birmingham, Birmingham, Alabama. · The Ohio State University Wexner Medical Center, Columbus, Ohio. · Johns Hopkins Medical Institute, Baltimore, Maryland. · Specialty Chair, UT Southwestern Medical Center, Dallas, Texas. ·J Am Coll Radiol · Pubmed #30392597.

ABSTRACT: Chronic chest pain (CCP) of a cardiac etiology is a common clinical problem. The diagnosis and classification of the case of chest pain has rapidly evolved providing the clinician with multiple cardiac imaging strategies. Though scintigraphy and rest echocardiography remain as appropriate imaging tools in the diagnostic evaluation, new technology is available. Current evidence supports the use of alternative imaging tests such as coronary computed tomography angiography (CCTA), cardiac MRI (CMRI), or Rb-82 PET/CT. Since multiple imaging modalities are available to the clinician, the most appropriate noninvasive imaging strategy will be based upon the patient's clinical presentation and clinical status. The American College of Radiology Appropriateness Criteria are evidence-based guidelines for specific clinical conditions that are reviewed annually by a multidisciplinary expert panel. The guideline development and revision include an extensive analysis of current medical literature from peer reviewed journals and the application of well-established methodologies (RAND/UCLA Appropriateness Method and Grading of Recommendations Assessment, Development, and Evaluation or GRADE) to rate the appropriateness of imaging and treatment procedures for specific clinical scenarios. In those instances where evidence is lacking or equivocal, expert opinion may supplement the available evidence to recommend imaging or treatment.

2 Guideline CAC-DRS: Coronary Artery Calcium Data and Reporting System. An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). 2018

Hecht, Harvey S / Blaha, Michael J / Kazerooni, Ella A / Cury, Ricardo C / Budoff, Matt / Leipsic, Jonathon / Shaw, Leslee. ·Division of Cardiology, Icahn School of Medicine at Mount Sinai, and Mount Sinai St. Luke's Medical Center, New York, NY, United States. Electronic address: harvey.hecht@mountsinai.org. · The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, United States. · Division of Radiology, University of Michigan Medical Center, Ann Arbor, MI 48109, United States. · Miami Cardiac and Vascular Institute, Baptist Hospital of Miami, 8900 N Kendall Drive, Miami, FL 33176, United States. · Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, United States. · Department of Medicine and Radiology, University of British Columbia, Vancouver, Canada. · Department of Medicine, Emory University School of Medicine, Atlanta, GA, United States. ·J Cardiovasc Comput Tomogr · Pubmed #29793848.

ABSTRACT: The goal of CAC-DRS: Coronary Artery Calcium Data and Reporting System is to create a standardized method to communicate findings of CAC scanning on all noncontrast CT scans, irrespective of the indication, in order to facilitate clinical decision-making, with recommendations for subsequent patient management. The CAC-DRS classification is applied on a per-patient basis and represents the total calcium score and the number of involved arteries. General recommendations are provided for further management of patients with different degrees of calcified plaque burden based on CAC-DRS classification. In addition, CAC-DRS will provide a framework of standardization that may benefit quality assurance and tracking patient outcomes with the potential to ultimately result in improved quality of care.

3 Guideline Clinical indications for coronary artery calcium scoring in asymptomatic patients: Expert consensus statement from the Society of Cardiovascular Computed Tomography. 2017

Hecht, Harvey / Blaha, Michael J / Berman, Daniel S / Nasir, Khurram / Budoff, Matthew / Leipsic, Jonathon / Blankstein, Ron / Narula, Jagat / Rumberger, John / Shaw, Leslee J. ·Division of Cardiology, Icahn School of Medicine at Mount Sinai, Mount Sinai St. Luke's Medical Center, New York, NY, USA. Electronic address: hhecht@aol.com. · The Johns Hopkins Ciccarone Center for the Prevention of Heart Disease, Baltimore, MD, USA. · Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, CA, USA. · Miami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA. · Division of Cardiology, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, CA, USA. · Department of Medicine and Radiology, University of British Columbia, Vancouver, Canada. · Non-Invasive Cardiovascular Imaging Program, Departments of Medicine (Cardiovascular Division) and Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. · Division of Cardiology, Icahn School of Medicine at Mount Sinai, Mount Sinai St. Luke's Medical Center, New York, NY, USA. · The Princeton Longevity Center, Princeton, NJ, USA. · Department of Medicine, Emory University School of Medicine, Atlanta, GA, USA. ·J Cardiovasc Comput Tomogr · Pubmed #28283309.

ABSTRACT: This expert consensus statement summarizes the available data regarding the prognostic value of CAC in the asymptomatic population and its ability to refine individual risk prediction, addresses the limitations identified in the current traditional risk factor-based treatment strategies recommended by the 2013 ACC/AHA Prevention guidelines including use of the Pooled Cohort Equations (PCE), and the US Preventive Services Task Force (USPSTF) Recommendation Statement for Statin Use for the Primary Prevention of Cardiovascular Disease in Adults. It provides CAC based treatment recommendations both within the context of the shared decision making model espoused by the 2013 ACC/AHA Prevention guidelines and independent of these guidelines.

4 Guideline SCCT guidelines for the performance and acquisition of coronary computed tomographic angiography: A report of the society of Cardiovascular Computed Tomography Guidelines Committee: Endorsed by the North American Society for Cardiovascular Imaging (NASCI). 2016

Abbara, Suhny / Blanke, Philipp / Maroules, Christopher D / Cheezum, Michael / Choi, Andrew D / Han, B Kelly / Marwan, Mohamed / Naoum, Chris / Norgaard, Bjarne L / Rubinshtein, Ronen / Schoenhagen, Paul / Villines, Todd / Leipsic, Jonathon. ·University of Texas Southwestern Medical Center, Dallas, TX, United States. Electronic address: Suhny.Abbara@UTSouthwestern.edu. · Department of Radiology and Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. · University of Texas Southwestern Medical Center, Dallas, TX, United States. · Cardiology Service Ft. Belvoir Community Hospital, Ft. Belvoir, VA, United States. · Division of Cardiology and Department of Radiology, The George Washington University School of Medicine, Washington DC, United States. · Minneapolis Heart Institute and Children's Heart Clinic, Minneapolis, MN, United States. · Cardiology Department, University Hospital, Erlangen, Germany. · Concord Hospital, The University of Sydney, Sydney, Australia. · Department of Cardiology B, Aarhus University Hospital-Skejby, Aarhus N, Denmark. · Lady Davis Carmel Medical Center & Rappaport School of Medicine- Technion- IIT, Haifa, Israel. · Cardiovascular Imaging, Cleveland Clinic Lerner College of Medicine, Cleveland, OH, United States. · Walter Reed National Military Medical Center, Bethesda, MD, United States. ·J Cardiovasc Comput Tomogr · Pubmed #27780758.

ABSTRACT: In response to recent technological advancements in acquisition techniques as well as a growing body of evidence regarding the optimal performance of coronary computed tomography angiography (coronary CTA), the Society of Cardiovascular Computed Tomography Guidelines Committee has produced this update to its previously established 2009 "Guidelines for the Performance of Coronary CTA" (1). The purpose of this document is to provide standards meant to ensure reliable practice methods and quality outcomes based on the best available data in order to improve the diagnostic care of patients. Society of Cardiovascular Computed Tomography Guidelines for the Interpretation is published separately (2). The Society of Cardiovascular Computed Tomography Guidelines Committee ensures compliance with all existing standards for the declaration of conflict of interest by all authors and reviewers for the purpose ofclarity and transparency.

5 Guideline 2016 Focused Update of the Canadian Cardiovascular Society Guidelines for the Management of Atrial Fibrillation. 2016

Macle, Laurent / Cairns, John / Leblanc, Kori / Tsang, Teresa / Skanes, Allan / Cox, Jafna L / Healey, Jeff S / Bell, Alan / Pilote, Louise / Andrade, Jason G / Mitchell, L Brent / Atzema, Clare / Gladstone, David / Sharma, Mike / Verma, Subodh / Connolly, Stuart / Dorian, Paul / Parkash, Ratika / Talajic, Mario / Nattel, Stanley / Verma, Atul / Anonymous6140880. ·Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. Electronic address: lmacle@mac.com. · University of British Columbia, Vancouver, British Columbia, Canada. · University Health Network, University of Toronto, Toronto, Ontario, Canada. · London Heart Institute, Western University, London, Ontario, Canada. · QEII Health Sciences Centre, Dalhousie University, Halifax, Nova Scotia, Canada. · McMaster University and Hamilton General Hospital, Hamilton, Ontario, Canada. · University of Toronto, Toronto, Ontario, Canada. · McGill University Health Centre, Montréal, Québec, Canada. · Montreal Heart Institute, Université de Montréal, Montreal, Quebec, Canada. · Libin Cardiovascular Institute of Alberta, University of Calgary, and Alberta Health Services, Calgary, Alberta, Canada. · Sunnybrook Health Sciences Centre and University of Toronto, Toronto, Ontario, Canada. · McMaster University and Hamilton General Hospital, Hamilton, Ontario, Canada; The Canadian Stroke Network, Ottawa, Ontario, Canada. · St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. · Southlake Regional Health Centre, Newmarket, Ontario, Canada. ·Can J Cardiol · Pubmed #27609430.

ABSTRACT: The Canadian Cardiovascular Society (CCS) Atrial Fibrillation (AF) Guidelines Committee provides periodic reviews of new data to produce focused updates that address clinically important advances in AF management. This 2016 Focused Update deals with: (1) the management of antithrombotic therapy for AF patients in the context of the various clinical presentations of coronary artery disease; (2) real-life data with non-vitamin K antagonist oral anticoagulants; (3) the use of antidotes for the reversal of non-vitamin K antagonist oral anticoagulants; (4) digoxin as a rate control agent; (5) perioperative anticoagulation management; and (6) AF surgical therapy including the prevention and treatment of AF after cardiac surgery. The recommendations were developed with the same methodology used for the initial 2010 guidelines and the 2012 and 2014 Focused Updates. Using the Grading of Recommendations, Assessment, Development, and Evaluation (GRADE) standards, individual studies and literature were reviewed for quality and bias; the literature review process and evidence tables are included in the Supplementary Material, and on the CCS Web site. The section on concomitant AF and coronary artery disease was developed in collaboration with the CCS Antiplatelet Guidelines Committee. Details of the updated recommendations are presented, along with their background and rationale. This document is linked to an updated summary of all CCS AF Guidelines recommendations, from 2010 to the present 2016 Focused Update.

6 Guideline Canadian Cardiovascular Society guidelines for the diagnosis and management of stable ischemic heart disease. 2014

Mancini, G B John / Gosselin, Gilbert / Chow, Benjamin / Kostuk, William / Stone, James / Yvorchuk, Kenneth J / Abramson, Beth L / Cartier, Raymond / Huckell, Victor / Tardif, Jean-Claude / Connelly, Kim / Ducas, John / Farkouh, Michael E / Gupta, Milan / Juneau, Martin / O'Neill, Blair / Raggi, Paolo / Teo, Koon / Verma, Subodh / Zimmermann, Rodney / Anonymous3830801. ·Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: mancini@mail.ubc.ca. · Department of Medicine, Montreal Heart Institute, University of Montreal, Montréal, Québec, Canada. · Department of Medicine, Ottawa Heart Institute, Ottawa, Ontario, Canada. · Department of Medicine, University of Western Ontario, London, Ontario, Canada. · Department of Medicine, University of Calgary, Calgary, Alberta, Canada. · Vancouver Island Health Authority, Victoria, British Columbia, Canada. · Department of Medicine, St Michael's Hospital, University of Toronto, Toronto, Ontario, Canada. · Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada. · Department of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. · Department of Medicine, University Health Network Hospitals, University of Toronto, Toronto, Onario, Canada. · Department of Medicine, McMaster University, Hamilton, Ontario, Canada. · Department of Medicine, University of Alberta, Edmonton, Alberta, Canada. · Department of Medicine, Regina Qu'Appelle Health Region, University of Saskatchewan, Regina, Saskatchewan, Canada. ·Can J Cardiol · Pubmed #25064578.

ABSTRACT: This overview provides a guideline for the management of stable ischemic heart disease. It represents the work of a primary and secondary panel of participants from across Canada who achieved consensus on behalf of the Canadian Cardiovascular Society. The suggestions and recommendations are intended to be of relevance to primary care and specialist physicians with an emphasis on rational deployment of diagnostic tests, expedited implementation of long- and short-term medical therapy, timely consideration of revascularization, and practical follow-up measures.

7 Editorial Coronary Computed Tomographic Angiography - The evidence dominates! 2017

Shaw, Leslee J / Villines, Todd / Blankstein, Ron / Abbara, Suhny / Weigold, Guy / Slim, Ahmad / Leipsic, Jonathon. ·Emory University School of Medicine, Atlanta, Georgia. Electronic address: lshaw3@emory.edu. · Walter Reed Medical Center, Bethesda, MD, United States. · Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States. · University of Texas Southwestern Medical Center, Dallas, TX, United States. · MedStar Washington Hospital Center, Washington DC, United States. · Tulane University School of Medicine, New Orleans, LA, United States. · The University of British Columbia, Vancouver, BC, Canada. ·J Cardiovasc Comput Tomogr · Pubmed #28017553.

ABSTRACT: -- No abstract --

8 Editorial Primary and Secondary Prevention, or Subclinical and Clinical Atherosclerosis. 2017

Ahmadi, Amir / Narula, Jagat. ·Icahn School of Medicine at Mount Sinai Hospital, New York, New York; University of British Columbia, Vancouver, Canada. · Icahn School of Medicine at Mount Sinai Hospital, New York, New York. Electronic address: narula@mountsinai.org. ·JACC Cardiovasc Imaging · Pubmed #27771400.

ABSTRACT: -- No abstract --

9 Editorial Developing a Deeper Understanding of Sex Differences in the Diagnostic Performance of Computed Tomographic Perfusion Imaging Toward a More Personalized Approach. 2016

Kueh, Shaw Hua Anthony / Sellers, Stephanie / Leipsic, Jonathon. ·From the Department of Radiology (S.H.K., S.S., J.L.) and Department of Cardiology (J.L.), University of British Columbia, Vancouver, Canada. · From the Department of Radiology (S.H.K., S.S., J.L.) and Department of Cardiology (J.L.), University of British Columbia, Vancouver, Canada. jleipsic@providencehealth.bc.ca. ·Circ Cardiovasc Imaging · Pubmed #27811152.

ABSTRACT: -- No abstract --

10 Editorial Diagnostic Algorithms for Stable Chest Pain: From Opinion to Science Lessons From PROMISE. 2016

Leipsic, Jonathon / Naoum, Christopher / Blanke, Philipp. ·Department of Medical Imaging and Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: jleipsic@providencehealth.bc.ca. · Department of Cardiology, Concord Hospital, The University of Sydney, Sydney, Australia. · Department of Medical Imaging and Division of Cardiology, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada. ·J Am Coll Cardiol · Pubmed #27256832.

ABSTRACT: -- No abstract --

11 Editorial Change is the law of life. And those who look only to the past or present are certain to miss the future. - John F. Kennedy. 2016

Leipsic, Jonathon A. ·Canada Research Chair, Advanced Cardiac Imaging and Vice Chairman of Radiology, University of British Columbia, Canada. Electronic address: jleipsic@providencehealth.bc.ca. ·J Cardiovasc Comput Tomogr · Pubmed #27145696.

ABSTRACT: -- No abstract --

12 Editorial President's Page. 2015

Leipsic, Jonathon A. ·Canada Research Chair, Advanced Cardiac Imaging and Vice Chairman of Radiology, University of British Columbia, Canada. Electronic address: jleipsic@providencehealth.bc.ca. ·J Cardiovasc Comput Tomogr · Pubmed #26411313.

ABSTRACT: -- No abstract --

13 Editorial Minimalist Approach to Evaluating Patients for Transcatheter Aortic Valve Replacement. 2015

Dvir, Danny. ·From the Department of Cardiology, St Paul's Hospital, Vancouver, Canada. danny.dvir@gmail.com. ·Circ Cardiovasc Interv · Pubmed #26160831.

ABSTRACT: -- No abstract --

14 Editorial Cardiac CT in asymptomatic diabetes mellitus: role of non-invasive atherosclerosis imaging in high-risk asymptomatic individuals. 2015

Cademartiri, Filippo / Maffei, Erica / Nistri, Stefano / Leipsic, Jonathon. ·Department of Radiology, Erasmus Medical Center University, Rotterdam, The Netherlands filippocademartiri@gmail.com. · Department of Radiology, Giovanni XXIII Clinic, Monastier di Treviso, Italy. · Department of Cardiology, CMSR, Altavilla Vicentina, Italy. · Department of Radiology, University of British Columbia, Vancouver, Canada. ·Eur Heart J Cardiovasc Imaging · Pubmed #26041310.

ABSTRACT: -- No abstract --

15 Editorial Is atherosclerotic heart disease in COPD a distinct phenotype? 2011

Man, S F Paul / Leipsic, Jonathon A / Man, Jonathan P / Sin, Donald D. ·Respirology Division, University of British Columbia, Vancouver, BC, Canada; St. Paul's Hospital, Vancouver, BC, Canada; University of British Columbia Institute for Heart + Lung Health, Vancouver, BC, Canada. Electronic address: pman@providencehealth.bc.ca. · Department of Radiology, University of British Columbia, Vancouver, BC, Canada; St. Paul's Hospital, Vancouver, BC, Canada. · Division of Cardiology, University of British Columbia, Vancouver, BC, Canada; St. Paul's Hospital, Vancouver, BC, Canada. · Respirology Division, University of British Columbia, Vancouver, BC, Canada; St. Paul's Hospital, Vancouver, BC, Canada; University of British Columbia Institute for Heart + Lung Health, Vancouver, BC, Canada. ·Chest · Pubmed #21896514.

ABSTRACT: -- No abstract --

16 Review Recent Developments in Sex-Related Differences in Presentation, Prognosis, and Management of Coronary Artery Disease. 2018

Parvand, Mahraz / Rayner-Hartley, Erin / Sedlak, Tara. ·Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. · Department of Medicine, Division of Cardiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: tara.sedlak@vch.ca. ·Can J Cardiol · Pubmed #29571423.

ABSTRACT: Coronary artery disease (CAD) is the most prevalent type of heart disease among women and men. Sex-related differences in the presentation, prognosis, and management of patients with CAD has been increasingly studied. Compared with men, women are more likely to present with multiple comorbidities, have a higher prevalence of psychological risk factors, and present with atypical symptoms. These factors, along with delays in seeking medical attention, might contribute to sex-related treatment differences in women with stable angina and acute coronary syndrome. This review article highlights recent evidence examining sex-related differences in stable CAD patients with obstructive CAD, nonobstructive CAD, as well as myocardial infarction.

17 Review 2018 Canadian Cardiovascular Society/Canadian Association of Interventional Cardiology Focused Update of the Guidelines for the Use of Antiplatelet Therapy. 2018

Mehta, Shamir R / Bainey, Kevin R / Cantor, Warren J / Lordkipanidzé, Marie / Marquis-Gravel, Guillaume / Robinson, Simon D / Sibbald, Matthew / So, Derek Y / Wong, Graham C / Abunassar, Joseph G / Ackman, Margaret L / Bell, Alan D / Cartier, Raymond / Douketis, James D / Lawler, Patrick R / McMurtry, Michael S / Udell, Jacob A / van Diepen, Sean / Verma, Subodh / Mancini, G B John / Cairns, John A / Tanguay, Jean-François / Anonymous921134. ·McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada. Electronic address: smehta@mcmaster.ca. · University of Alberta and Mazankowski Alberta Heart Institute, Edmonton, Alberta, Canada. · University of Toronto and Southlake Regional Health Centre, Toronto, Ontario, Canada. · Université de Montréal and Institut de Cardiologie de Montréal, Montréal, Quebec, Canada. · Royal Jubilee Hospital, University of British Columbia, Victoria, British Columbia, Canada. · McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada. · University of Ottawa Heart Institute, Ottawa, Ontario, Canada. · University of British Columbia and Vancouver General Hospital, Vancouver, British Columbia, Canada. · University of Toronto, Toronto, Ontario, Canada. · McMaster University and St Joseph's Healthcare Hamilton, Hamilton, Ontario, Canada. · University of Toronto and Women's College Hospital and Peter Munk Cardiac Centre of Toronto General Hospital, Toronto, Ontario, Canada. · University of Toronto and St Michael's Hospital, Toronto, Ontario, Canada. · Université de Montréal and Institut de Cardiologie de Montréal, Montréal, Quebec, Canada. Electronic address: jean-francois.tanguay@icm-mhi.org. ·Can J Cardiol · Pubmed #29475527.

ABSTRACT: Antiplatelet therapy (APT) has become an important tool in the treatment and prevention of atherosclerotic events, particularly those associated with coronary artery disease. A large evidence base has evolved regarding the relationship between APT prescription in various clinical contexts and risk/benefit relationships. The Guidelines Committee of the Canadian Cardiovascular Society and Canadian Association of Interventional Cardiology publishes regular updates of its recommendations, taking into consideration the most recent clinical evidence. The present update to the 2011 and 2013 Canadian Cardiovascular Society APT guidelines incorporates new evidence on how to optimize APT use, particularly in situations in which few to no data were previously available. The recommendations update focuses on the following primary topics: (1) the duration of dual APT (DAPT) in patients who undergo percutaneous coronary intervention (PCI) for acute coronary syndrome and non-acute coronary syndrome indications; (2) management of DAPT in patients who undergo noncardiac surgery; (3) management of DAPT in patients who undergo elective and semiurgent coronary artery bypass graft surgery; (4) when and how to switch between different oral antiplatelet therapies; and (5) management of antiplatelet and anticoagulant therapy in patients who undergo PCI. For PCI patients, we specifically analyze the particular considerations in patients with atrial fibrillation, mechanical or bioprosthetic valves (including transcatheter aortic valve replacement), venous thromboembolic disease, and established left ventricular thrombus or possible left ventricular thrombus with reduced ejection fraction after ST-segment elevation myocardial infarction. In addition to specific recommendations, we provide values and preferences and practical tips to aid the practicing clinician in the day to day use of these important agents.

18 Review Coronary CT Angiography Derived Fractional Flow Reserve: The Game Changer in Noninvasive Testing. 2017

Nørgaard, Bjarne Linde / Jensen, Jesper Møller / Blanke, Philipp / Sand, Niels Peter / Rabbat, Mark / Leipsic, Jonathon. ·Department Cardiology, Aarhus University Hospital, 8200, Aarhus N, Denmark. bnorgaard@dadlnet.dk. · Department Cardiology, Aarhus University Hospital, 8200, Aarhus N, Denmark. · Department of Radiology and Medicine, St. Paul´s Hospital, University of British Columbia, Vancouver, Canada. · Department Cardiology, Hospital of South West Denmark, Esbjerg, and Institute of regional Health Research, University of Southern Denmark, Esbjerg, Denmark. · Medicine and Radiology, Division of Cardiology, Loyola University Chicago, Chicago, Illinois, USA. ·Curr Cardiol Rep · Pubmed #28940026.

ABSTRACT: PURPOSE OF REVIEW: To summarize the scientific basis of CT derived fractional flow reserve (FFR

19 Review Noninvasive assessment of subclinical atherosclerosis in persons with symptoms of depression. 2017

Ali, Shozab S / Khan, Sher A / Khosa, Faisal / Aneni, Ehimen C / Jones, Andrew / St Leger, Antony Selwyn / Feiz, Hamid R / Cury, Ricardo C / Agatston, Arthur S / Nasir, Khurram. ·Center for Healthcare Advancement and Outcomes, Baptist Health Medical Group, Miami, FL, USA; University of Manchester, Faculty of Biology, Medicine and Health, Manchester, United Kingdom; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA. Electronic address: ShozabSA@baptisthealth.net. · Center for Healthcare Advancement and Outcomes, Baptist Health Medical Group, Miami, FL, USA. · University of British Columbia, Vancouver, Canada. · University of Manchester, Faculty of Biology, Medicine and Health, Manchester, United Kingdom. · Aventura Hospital & Medical Center, Aventura, FL, USA. · Miami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA. · Center for Healthcare Advancement and Outcomes, Baptist Health Medical Group, Miami, FL, USA; Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA; Miami Cardiac and Vascular Institute, Baptist Health South Florida, Miami, FL, USA; Robert Stempel College of Public Health, Florida International University, Miami, FL, USA; Ciccarone Center for the Prevention of Heart Disease, Johns Hopkins University, Baltimore, MD, USA. ·Atherosclerosis · Pubmed #28760375.

ABSTRACT: BACKGROUND AND AIMS: Depression is a mood disorder characterized by persistent feelings of loss of interest along with a cluster of clinical symptoms. It is a significant public health concern affecting 350 million people worldwide. Depression has an association with increased risk of cardiovascular disease. The World Health Organization estimates both depression and coronary artery disease to be the two major causes of disability-adjusted life years by year 2020. Early identification of subclinical cardiovascular disease in people suffering from depression may significantly impact risk stratification of these patients. METHODS: An electronic search of MEDLINE database was carried out using PubMed and OvidSP. Subclinical atherosclerosis was identified by coronary artery calcium (CAC). A total of 24 studies were identified to be included in the review. RESULTS: In this review of twenty-four studies, we found that twelve studies identified a positive association between depression and subclinical atherosclerosis. Ten studies found no significant association between depressive symptoms and coronary calcification. Whereas, two studies showed negative association. CONCLUSIONS: There is mixed evidence assessing the relationship between depression and CAC. Depressive symptoms may represent a potentially modifiable risk factor for early prevention of cardiovascular disease especially in younger patients with moderate to severe depression.

20 Review Interpreting results of coronary computed tomography angiography-derived fractional flow reserve in clinical practice. 2017

Rabbat, Mark G / Berman, Daniel S / Kern, Morton / Raff, Gilbert / Chinnaiyan, Kavitha / Koweek, Lynne / Shaw, Leslee J / Blanke, Philipp / Scherer, Markus / Jensen, Jesper M / Lesser, John / Nørgaard, Bjarne L / Pontone, Gianluca / De Bruyne, Bernard / Bax, Jeroen J / Leipsic, Jonathon. ·Department of Medicine and Radiology, Division of Cardiology, Loyola University Chicago, Chicago, IL, USA; Edward Hines Jr. Veteran's Affairs Hospital, Hines, IL, USA. Electronic address: mrabbat@lumc.edu. · Cedars-Sinai Medical Center, Department of Imaging, USA. · VA Long Beach HCS, Department of Cardiology, University of California Irvine, USA. · Beaumont Health, Department of Cardiology, USA. · Duke University, Department of Medicine and Radiology, USA. · Emory University, Department of Cardiology, USA. · St. Paul's Hospital & University of British Columbia, Department of Radiology, Canada. · Sanger Heart and Vascular Institute, Department of Cardiology, USA. · Aarhus University Hospital, Department of Cardiology, Denmark. · Minneapolis Heart Institute, USA. · Cardiologico Monzino, Department of Cardiovascular Imaging, Milan, Italy. · OLV Ziekenhuis Aalst, Cardiovascular Center Aalst, Belgium. · Leiden University Medical Center, Department of Cardiology, The Netherlands. ·J Cardiovasc Comput Tomogr · Pubmed #28666784.

ABSTRACT: The application of computational fluid dynamics to coronary computed tomography angiography allows Fractional Flow Reserve (FFR) to be calculated non-invasively (FFR

21 Review Update on the clinical utility of coronary computed tomographic angiography in stable angina pectoris. 2017

Kueh, Shaw H / Naoum, Christopher. ·Radiology Department, St Paul's Hospital, Vancouver, Canada. · Cardiology Department, Concord Hospital, The University of Sydney, Sydney, Australia - chris.naoum@gmail.com. ·Minerva Cardioangiol · Pubmed #28406279.

ABSTRACT: Over the last decade, coronary computed tomographic angiography (CCTA) has emerged as a valuable non-invasive imaging modality with excellent diagnostic performance compared to invasive coronary angiography (ICA) for identifying patients with coronary artery disease (CAD). Beyond the diagnosis of CAD, CCTA also provides valuable prognostic information. While patients with normal CCTA have excellent long-term prognosis, among those with CAD, increasing CAD extent and severity is associated with increased cardiovascular event risk over both medium- and long-term follow-up in both men and women. The ability to image non-obstructive CAD is a particularly unique attribute of CCTA. Moreover, the ability to assess plaque features on CCTA has further enhanced our understanding of coronary plaque dynamics and the prediction of future cardiovascular events. The clinical impact of CCTA has been recently evaluated in two landmark prospective multicenter trials, which have provided insights into the influence of CCTA on the clinical management of symptomatic patients with suspected CAD. We review the value of CCTA in the evaluation of patients with stable chest pain including its diagnostic performance, prognostic utility and real-world clinical application.

22 Review The 100 most-cited original articles in cardiac computed tomography: A bibliometric analysis. 2016

O'Keeffe, Michael E / Hanna, Tarek N / Holmes, Davis / Marais, Olivia / Mohammed, Mohammed F / Clark, Sheldon / McLaughlin, Patrick / Nicolaou, Savvas / Khosa, Faisal. ·Department of Emergency & Trauma Radiology, Vancouver General Hospital, Vancouver, CA, Canada. Electronic address: dr.meokeeffe@gmail.com. · Division of Emergency Radiology, Department of Radiology and Imaging Sciences, Emory University, Atlanta, GA, USA. · Department of Emergency & Trauma Radiology, Vancouver General Hospital, Vancouver, CA, Canada. ·J Cardiovasc Comput Tomogr · Pubmed #27452312.

ABSTRACT: Bibliometric analysis is the application of statistical methods to analyze quantitative data about scientific publications. It can evaluate research performance, author productivity, and manuscript impact. To the best of our knowledge, no bibliometric analysis has focused on cardiac computed tomography (CT). The purpose of this paper was to compile a list of the 100 most-cited articles related to cardiac CT literature using Scopus and Web of Science (WOS). A list of the 100 most-cited articles was compiled by order of citation frequency, as well a list of the top 10 most-cited guideline and review articles and the 20 most-cited articles of the years 2014-2015. The database of 100 most-cited articles was analyzed to identify characteristics of highly cited publications. For each manuscript, the number of authors, study design, size of patient cohort and departmental affiliations were cataloged. The 100 most-cited articles were published from 1990 to 2012, with the majority (53) published between 2005 and 2009. The total number of citations varied from 3354 to 196, and the number of citations per year varied from 9.5 to 129.0 with a median and mean of 30.9 and 38.7, respectively. The majority of publications had a study patients sample size of 200 patients or less. The USA and Germany were the nations with the highest number of frequently cited publications. This bibliometric analysis provides insights on the most-cited articles published on the subject of cardiac CT and calcium volume, thus helping to characterize the field and guide future research.

23 Review Prognostic Determinants of Coronary Atherosclerosis in Stable Ischemic Heart Disease: Anatomy, Physiology, or Morphology? 2016

Ahmadi, Amir / Stone, Gregg W / Leipsic, Jonathon / Shaw, Leslee J / Villines, Todd C / Kern, Morton J / Hecht, Harvey / Erlinge, David / Ben-Yehuda, Ori / Maehara, Akiko / Arbustini, Eloisa / Serruys, Patrick / Garcia-Garcia, Hector M / Narula, Jagat. ·From the Mount Sinai Heart, Icahn School of Medicine at Mount Sinai, New York, NY (A.A., H.H., J.N.) · Columbia University Medical Center, Cardiovascular Research Foundation, New York, NY (G.W.S., A.M.) · University of British Columbia, Vancouver, British Columbia, Canada (A.A., J.L.) · Emory University School of Medicine, Atlanta, GA (L.J.S.) · Walter Reed National Military Medical Center, Bethesda, MD (T.C.V.) · University of California Irvine (M.J.K.) · Lund University, Sweden (D.E.) · University of California San Diego (O.B.-Y.) · Policlinico San Matteo Pavia Fondazione, Pravia, Italy (E.A.) · Imperial College, London, United Kingdom (P.S.) · and Leesburg Regional Medical Centre, FL (H.M.G.-G.). ·Circ Res · Pubmed #27390334.

ABSTRACT: Risk stratification in patients with stable ischemic heart disease is essential to guide treatment decisions. In this regard, whether coronary anatomy, physiology, or plaque morphology is the best determinant of prognosis (and driver an effective therapeutic risk reduction) remains one of the greatest ongoing debates in cardiology. In the present report, we review the evidence for each of these characteristics and explore potential algorithms that may enable a practical diagnostic and therapeutic strategy for the management of patients with stable ischemic heart disease.

24 Review Beyond Stenosis With Fractional Flow Reserve Via Computed Tomography and Advanced Plaque Analyses for the Diagnosis of Lesion-Specific Ischemia. 2016

Cheruvu, Chaitu / Naoum, Christopher / Blanke, Philipp / Norgaard, Bjarne / Leipsic, Jonathon. ·Department of Radiology, University of British Columbia, Vancouver, British Columbia, Canada. · Department of Cardiology, Aarhus University Hospital, Aarhus Skejby, Denmark. · Department of Medicine and Radiology, University of British Columbia, Vancouver, British Columbia, Canada. Electronic address: jleipsic@providencehealth.bc.ca. ·Can J Cardiol · Pubmed #27032888.

ABSTRACT: In the treatment of stable coronary artery disease (CAD), the determination of stenosis severity by invasive coronary angiography (ICA) is a critical procedure, and for borderline lesions, the detection of ischemia through invasive fractional flow reserve (FFR) is the gold standard. With advances in computational fluid dynamics, FFR can now be calculated noninvasively using anatomic data from coronary computed tomographic angiography (CCTA). This technique is known as FFR

25 Review Is it Time to Update How Suspected Angina Is Evaluated prior to the Use of Specialized Tests Implications Based on a Systematic Review. 2016

Tashakkor, A Yashar / Stone, James / Mancini, G B John. ·Department of Medicine, University of British Columbia, Vancouver, B.C., Canada. ·Cardiology · Pubmed #26613257.

ABSTRACT: OBJECTIVES: Appropriate use of specialized tests to assess chest pain is based classically on minimal information such as age, gender and the patient's description of pain. This approach has not been reevaluated in decades. We examined the relationship between history, examination and routine laboratory tests to identify factors warranting prospective validation as predictors of underlying coronary artery disease (CAD). METHODS: Studies linking obstructive CAD (≥50% diameter stenosis of at least one vessel by invasive angiography or cardiac computed tomographic angiography) and elements of history, examination and laboratory tests were identified. RESULTS: Forty-one prospectively identified papers were analyzed. Advanced age, gender and chest pain descriptors were extremely important, although the last was less so in women, in whom the presence of risk factors may be more important. Physical examination and chest X-ray were largely noncontributory. Laboratory tests were of variable utility other than to identify risk factors not already known from the history. However, biomarkers such as troponin, brain natriuretic factor and inflammatory markers were promising. The electrocardiogram was mainly important for the identification of ST-T abnormalities. CONCLUSIONS: This review identifies the most promising factors warranting prospective validation for improving the pretest probability estimation of CAD, so appropriate use criteria for the utilization of specialized diagnostic tests can be updated and improved.

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