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Depression: HELP
Articles by Giovanni Cizza
Based on 6 articles published since 2010
(Why 6 articles?)

Between 2010 and 2020, G. Cizza wrote the following 6 articles about Depression.
+ Citations + Abstracts
1 Editorial An ounce of prevention: securing bone health in adolescence. 2013

Cizza, Giovanni / Rother, Kristina I. · ·J Adolesc Health · Pubmed #23521896.

ABSTRACT: -- No abstract --

2 Review Chronic sleep deprivation and seasonality: implications for the obesity epidemic. 2011

Cizza, G / Requena, M / Galli, G / de Jonge, L. ·Section on Neuroendocrinology of Obesity, NIDDK, Bethesda, MD, USA. cizzag@intra.niddk.nih.gov ·J Endocrinol Invest · Pubmed #21720205.

ABSTRACT: Sleep duration has progressively fallen over the last 100 years while obesity has increased in the past 30 years. Several studies have reported an association between chronic sleep deprivation and long-term weight gain. Increased energy intake due to sleep loss has been listed as the main mechanism. The consequences of chronic sleep deprivation on energy expenditure have not been fully explored. Sleep, body weight, mood and behavior are subjected to circannual changes. However, in our modern environment seasonal changes in light and ambient temperature are attenuated. Seasonality, defined as cyclic changes in mood and behavior, is a stable personality trait with a strong genetic component. We hypothesize that the attenuation in seasonal changes in the environment may produce negative consequences, especially in individuals more predisposed to seasonality, such as women. Seasonal affective disorder, a condition more common in women and characterized by depressed mood, hypersomnia, weight gain, and carbohydrate craving during the winter, represents an extreme example of seasonality. One of the postulated functions of sleep is energy preservation. Hibernation, a phenomenon characterized by decreased energy expenditure and changes in the state of arousal, may offer useful insight into the mechanisms behind energy preservation during sleep. The goals of this article are to: a) consider the contribution of changes in energy expenditure to the weight gain due to sleep loss; b) review the phenomena of seasonality, hibernation, and their neuroendocrine mechanisms as they relate to sleep, energy expenditure, and body weight regulation.

3 Review Major depressive disorder is a risk factor for low bone mass, central obesity, and other medical conditions. 2011

Cizza, Giovanni. ·Diabetes, Obesity, Endocrine Branch, NIDDK, NIH, DHHS, Department of Laboratory Medicine, Clinical Center, Bethesda, Maryland 20892-1613, USA. cizzag@intra.niddk.nih.gov ·Dialogues Clin Neurosci · Pubmed #21485748.

ABSTRACT: Major depressive disorder (MDD) is one of the most common psychiatric illnesses in the adult population. It is often associated with an increased risk of cardiovascular disease. Osteoporosis is also a major public health threat. Multiple studies have reported an association between depression and low bone mineral density, but a causal link between these two conditions is disputed. Here the most important findings of the POWER (Premenopausal, Osteoporosis Women, Alendronate, Depression) Study, a large prospective study of bone turnover in premenopausal women with major depression, are summarized. The endocrine and immune alterations secondary to depression that might affect bone mass, and the possible role of poor lifestyle in the etiology of osteoporosis in subjects with depression, are also reviewed, as is the potential effect of antidepressants on bone loss. It is proposed that depression induces bone loss and osteoporotic fractures, primarily via specific immune and endocrine mechanisms, with poor lifestyle habits as potential contributory factors.

4 Clinical Trial Do premenopausal women with major depression have low bone mineral density? A 36-month prospective study. 2012

Cizza, Giovanni / Mistry, Sima / Nguyen, Vi T / Eskandari, Farideh / Martinez, Pedro / Torvik, Sara / Reynolds, James C / Gold, Philip W / Sinaii, Ninet / Csako, Gyorgy / Anonymous240733. ·Section on Neuroendocrinology of Obesity, National Institutes of Diabetes and Digestive Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, Maryland, United States of America. cizzag@intra.niddk.nih.gov ·PLoS One · Pubmed #22848407.

ABSTRACT: BACKGROUND: An inverse relationship between major depressive disorder (MDD) and bone mineral density (BMD) has been suggested, but prospective evaluation in premenopausal women is lacking. METHODS: Participants of this prospective study were 21 to 45 year-old premenopausal women with MDD (n = 92) and healthy controls (n = 44). We measured BMD at the anteroposterior lumbar spine, femoral neck, total hip, mid-distal radius, trochanter, and Ward's triangle, as well as serum intact parathyroid hormone (iPTH), ionized calcium, plasma adrenocorticotropic hormone (ACTH), serum cortisol, and 24-hour urinary-free cortisol levels at 0, 6, 12, 24, and 36 months. 25-hydroxyvitamin D was measured at baseline. RESULTS: At baseline, BMD tended to be lower in women with MDD compared to controls and BMD remained stable over time in both groups. At baseline, 6, 12, and 24 months intact PTH levels were significantly higher in women with MDD vs. controls. At baseline, ionized calcium and 25-hydroxyvitamin D levels were significantly lower in women with MDD compared to controls. At baseline and 12 months, bone-specific alkaline phosphatase, a marker of bone formation, was significantly higher in women with MDD vs. controls. Plasma ACTH was also higher in women with MDD at baseline and 6 months. Serum osteocalcin, urinary N-telopeptide, serum cortisol, and urinary free cortisol levels were not different between the two groups throughout the study. CONCLUSION: Women with MDD tended to have lower BMD than controls over time. Larger and longer studies are necessary to extend these observations with the possibility of prophylactic therapy for osteoporosis. TRIAL REGISTRATION: ClinicalTrials.gov NCT 00006180.

5 Clinical Trial Clinical subtypes of depression are associated with specific metabolic parameters and circadian endocrine profiles in women: the power study. 2012

Cizza, Giovanni / Ronsaville, Donna S / Kleitz, Hayley / Eskandari, Farideh / Mistry, Sejal / Torvik, Sara / Sonbolian, Nina / Reynolds, James C / Blackman, Marc R / Gold, Philip W / Martinez, Pedro E / Anonymous1180715. ·Section on Neuroendocrinology of Obesity, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland, United States of America. cizzag@intra.niddk.nih.gov ·PLoS One · Pubmed #22235252.

ABSTRACT: BACKGROUND: Major depressive disorder (MDD) has been associated with adverse medical consequences, including cardiovascular disease and osteoporosis. Patients with MDD may be classified as having melancholic, atypical, or undifferentiated features. The goal of the present study was to assess whether these clinical subtypes of depression have different endocrine and metabolic features and consequently, varying medical outcomes. METHODS: Premenopausal women, ages 21 to 45 years, with MDD (N = 89) and healthy controls (N = 44) were recruited for a prospective study of bone turnover. Women with MDD were classified as having melancholic (N = 51), atypical (N = 16), or undifferentiated (N = 22) features. Outcome measures included: metabolic parameters, body composition, bone mineral density (BMD), and 24 hourly sampling of plasma adrenocorticotropin (ACTH), cortisol, and leptin. RESULTS: Compared with control subjects, women with undifferentiated and atypical features of MDD exhibited greater BMI, waist/hip ratio, and whole body and abdominal fat mass. Women with undifferentiated MDD characteristics also had higher lipid and fasting glucose levels in addition to a greater prevalence of low BMD at the femoral neck compared to controls. Elevated ACTH levels were demonstrated in women with atypical features of depression, whereas higher mean 24-hour leptin levels were observed in the melancholic subgroup. CONCLUSIONS: Pre-menopausal women with various features of MDD exhibit metabolic, endocrine, and BMD features that may be associated with different health consequences. TRIAL REGISTRATION: ClinicalTrials.gov NCT00006180.

6 Article Cytokine Patterns in Healthy Adolescent Girls: Heterogeneity Captured by Variable and Person-Centered Statistical Strategies. 2016

Dorn, Lorah D / Gayles, Jochebed G / Engeland, Christopher G / Houts, Renate / Cizza, Giovanni / Denson, Lee A. ·From the College of Nursing (Dorn, Engeland), The Pennsylvania State University · Prevention Research Center (Gayles), The Pennsylvania State University · Department of Biobehavioral Health (Engeland), The Pennsylvania State University, University Park, Pennsylvania · Department of Psychology and Neuroscience (Houts), Duke University, Durham, North Carolina · National Institute of Child Health and Human Development (Cizza), National Institutes of Health, Bethesda, Maryland · Pediatric Gastroenterology (Denson), Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio · and University of Cincinnati School of Medicine (Denson), Cincinnati, Ohio. ·Psychosom Med · Pubmed #27187849.

ABSTRACT: BACKGROUND: Little is known about variation in individual cytokines/cytokine profiles for a large healthy, pediatric population. When cytokines in a healthy group are not abnormally high as in a disease state, it is challenging to determine appropriate statistical strategies. The aims of the study were (1) to describe variation among cytokine concentrations and profiles in healthy adolescent girls, (2) to illustrate utility of data reduction approaches novel to cytokine research, (variable-centered [principal factor analysis, PFA], person-centered [latent profile analysis, LPA]), and (3) to demonstrate utility of such methods in linking cytokine profiles to health outcomes (e.g., depressive, anxiety symptoms). METHOD: Serum was analyzed for 13 cytokines representing adaptive and innate immune responses in 262 girls (age = 11, 13, 15, and 17 years). RESULTS: There was great variation in cytokine concentrations. PFA revealed a four-factor solution explaining 73.13% of the shared variance among 13 cytokines (e.g., factor 1 included interleukin [IL]-4, IL-13, IL-5, interferon gamma; 26.65% of the shared variance). The LPA supported classifying girls into subgroups characterized by "high overall" (7.3% of sample), "high adaptive" (26.7%), "high innate" (21%), or "low overall" (45%) cytokine levels. Factors and profiles were useful in describing individual differences in depressive/anxiety symptoms (e.g., factor 1 positively associated with depressive symptoms but negatively with trait anxiety; increased depressive symptoms or trait anxiety was associated with greater likelihood of being in the "high adaptive" group). CONCLUSIONS: Healthy girls showed differences in cytokine levels and patterns of variation and important associations with psychological variables. PFA and LPA offer novel approaches useful for examining cytokine panels in healthy populations.