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Depression: HELP
Articles from Serbia
Based on 177 articles published since 2008

These are the 177 published articles about Depression that originated from Serbia during 2008-2019.
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8
1 Editorial Assessment of depression and anxiety in patients before and after percutaneous coronary intervention: A step forward in cardiac rehabilitation? 2018

Nedeljkovic, Ivana. ·1 Cardiology Clinic, Clinical Centre of Serbia, Belgrade, Serbia. · 2 School of Medicine, University of Belgrade, Serbia. ·Eur J Prev Cardiol · Pubmed #29707962.

ABSTRACT: -- No abstract --

2 Editorial Vascular depression consensus report - a critical update. 2016

Aizenstein, Howard J / Baskys, Andrius / Boldrini, Maura / Butters, Meryl A / Diniz, Breno S / Jaiswal, Manoj Kumar / Jellinger, Kurt A / Kruglov, Lev S / Meshandin, Ivan A / Mijajlovic, Milija D / Niklewski, Guenter / Pospos, Sarah / Raju, Keerthy / Richter, Kneginja / Steffens, David C / Taylor, Warren D / Tene, Oren. ·Department of Psychiatry, University of Pittsburgh Medical Center, Pittsburgh, PA, USA. · Memory Disorders Clinic, Riverside Psychiatric Medical Group, Riverside, CA, USA. · Department of Psychiatry, Columbia University, New York, NY, USA. · Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, New York, NY, USA. · Department of Psychiatry, University of Pittsburgh Medical School, Pittsburgh, PA, USA. · Department of Psychiatry and Behavioral Sciences, University of Texas Health Science Center at Houston, Houston, TX, USA. · Division of Molecular Imaging and Neuropathology, New York State Psychiatric Institute, Columbia University, New York, NY, USA. · Institute of Clinical Neurobiology, Alberichgasse 5/13, Vienna, A-1150, Austria. kurt.jellinger@univie.ac.at. · Department of Geriatric Psychiatry of the St. Petersburg Psychoneurological Research Institute named after V. M. Bekhterev, Medical Faculty of St. Petersburg University, St. Petersburg, Russia. · Clinical Department, Scientific and Practical Center of Psychoneurology named after V. M. Soloviev, St. Petersburg, Russia. · Neurology Clinic, Clinical Center of Serbia, School of Medicine University of Belgrade, Belgrade, Serbia. · University Clinic for Psychiatry and Psychotherapy, Paracelsus Private Medical University, Nuremberg, Germany. · Consultant in Old Age Psychiatry, Cheshire and Wirral Partnership NHS Foundation Trust, Chester, UK. · Faculty for Social Sciences, Technical University of Nuremberg Georg Simon Ohm, Nuremberg, Germany. · Department of Psychiatry, University of Connecticut Health Center, Farmington, CT, USA. · Department of Psychiatry, The Center for Cognitive Medicine, Vanderbilt University Medical Center, Nashville, TN, USA. · Department of Veterans Affairs Medical Center, The Geriatric Research, Education, and Clinical Center (GRECC), Tennessee Valley Healthcare System, Nashville, TN, USA. · Departments of Neurology and Psychiatry, Tel Aviv Medical Center, Tel Aviv, Israel. · Tel Aviv University, Sackler Faculty of Medicine, Tel Aviv, Israel. ·BMC Med · Pubmed #27806704.

ABSTRACT: BACKGROUND: Vascular depression is regarded as a subtype of late-life depression characterized by a distinct clinical presentation and an association with cerebrovascular damage. Although the term is commonly used in research settings, widely accepted diagnostic criteria are lacking and vascular depression is absent from formal psychiatric manuals such as the Diagnostic and Statistical Manual of Mental Disorders, 5 DISCUSSION: This diagnosis, based on clinical and MRI findings, suggests that vascular lesions lead to depression by disruption of frontal-subcortical-limbic networks involved in mood regulation. However, despite multiple MRI approaches to shed light on the spatiotemporal structural changes associated with late life depression, the causal relationship between brain changes, related lesions, and late life depression remains controversial. While postmortem studies of elderly persons who died from suicide revealed lacunes, small vessel, and Alzheimer-related pathologies, recent autopsy data challenged the role of these lesions in the pathogenesis of vascular depression. Current data propose that the vascular depression connotation should be reserved for depressed older patients with vascular pathology and evident cerebral involvement. Based on current knowledge, the correlations between intra vitam neuroimaging findings and their postmortem validity as well as the role of peripheral markers of vascular disease in late life depression are discussed. CONCLUSION: The multifold pathogenesis of vascular depression as a possible subtype of late life depression needs further elucidation. There is a need for correlative clinical, intra vitam structural and functional MRI as well as postmortem MRI and neuropathological studies in order to confirm the relationship between clinical symptomatology and changes in specific brain regions related to depression. To elucidate the causal relationship between regional vascular brain changes and vascular depression, animal models could be helpful. Current treatment options include a combination of vasoactive drugs and antidepressants, but the outcomes are still unsatisfying.

3 Review Breast cancer and its impact in male transsexuals. 2018

Nikolić, Dejan / Granić, Miroslav / Ivanović, Nebojša / Zdravković, Darko / Nikolić, Aleksandra / Stanimirović, Violeta / Zdravković, Marija / Dikić, Srdjan / Nikolić, Marko / Djordjević, Miroslav. ·Faculty of Medicine, University of Belgrade, Belgrade, Serbia. nikolicdrdejan@gmail.com. · University Medical Center Bežanijska kosa, Str. George Matheo bb, 11080, Belgrade, Serbia. nikolicdrdejan@gmail.com. · Faculty of Medicine, University of Belgrade, Belgrade, Serbia. · University Medical Center Bežanijska kosa, Str. George Matheo bb, 11080, Belgrade, Serbia. · Institute for Cardiovascular Diseases Dedinje, Belgrade, Serbia. · Medicine and Medical Devices Agency of Republic of Serbia, Belgrade, Serbia. · Children's Hospital, Belgrade, Serbia. ·Breast Cancer Res Treat · Pubmed #29974289.

ABSTRACT: INTRODUCTION: Lesbian, gay, and bisexuals have unique healthcare needs. Breast cancer is leading cancer in women, worldwide, accounting for 25% of all cases. Annual incidence rates increased significantly in all countries and age groups. The occurrence of breast cancer is rare in transgender population. As they have very limited access to medical care, it is much less likely to pursue breast cancer screening than in other individuals not identified as transgender. REVIEW OF THE CASES FROM LITERATURE: Up to date, only 13 cases of the breast cancer transsexuals (female to male) have been reported in six published papers worldwide. Histological examination of the breast tumor in female-to-male transgender showed progesterone/estrogen-positive invasive ductal carcinoma. DISCUSSION: Gender identity describes a person's inherent sense of being a woman, man, or of neither gender, whereas sexual orientation refers to how people identify their physical and emotional attraction to others. Gender reassignment surgery, as series of complex surgical genital and non-genital procedures, is recognized as the most effective treatment for patients with gender dysphoria. The two main principles of hormone therapy for transgender patients are to reduce endogenous hormone levels and their associated sex characteristics and replace them with hormones of the preferred sex. Breast cancer infrequently occurs in transgender patients. Even breast core biopsies can be difficult for interpreting after changes in breast tissue in female-to-male transsexuals following gender reassignment. CONCLUSION: Reviewing the literature, so many different data concerning probability of breast cancer in sexual minority can be found. Breast cancer screening program should be offered to all transgender individuals according to national guidelines. Very important is to take into consideration a transgender person's natal and surgical anatomy, unique clinical concerns for depression and anxiety, risk of suicide together with risk factors including experiences of harassment or physical or sexual violence, low education level, and unemployment. Understanding the need for mammography in these often marginalized groups is very important in addressing breast cancer disparities despite differences in insurance coverage in some countries and greater concern for the cancer of the breast in residual breast tissue. The best screening rule, ever, for breast cancer in male transsexuals and other similar population should be, besides surgical history and hormonal status, "Screen Now, Screen Regularly and Screen What You Have."

4 Review Therapeutic Strategies for Treatment of Inflammation-related Depression. 2018

Adzic, Miroslav / Brkic, Zeljka / Mitic, Milos / Francija, Ester / Jovicic, Milica J / Radulovic, Jelena / Maric, Nadja P. ·Department of Molecular Biology and Endocrinology, VINCA Institute of Nuclear Sciences, University of Belgrade, Serbia. · Clinic for Psychiatry, Clinical Centre of Serbia, Pasterova 2, 11000, Belgrade, Serbia. · Department of Psychiatry and Behavioral Sciences, The Asher Center of Study and Treatment of Depressive Disorders, Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States. · School of Medicine, University of Belgrade, Dr Subotica 8, 11000, Belgrade, Serbia. ·Curr Neuropharmacol · Pubmed #28847294.

ABSTRACT: BACKGROUND: Mounting evidence demonstrates enhanced systemic levels of inflammatory mediators in depression, indicating that inflammation may play a role in the etiology and course of mood disorders. Indeed, proinflammatory cytokines induce a behavioral state of conservation- withdrawal resembling human depression, characterized by negative mood, fatigue, anhedonia, psychomotor retardation, loss of appetite, and cognitive deficits. Neuroinflammation also contributes to non-responsiveness to current antidepressant (AD) therapies. Namely, response to conventional AD medications is associated with a decrease in inflammatory biomarkers, whereas resistance to treatment is accompanied by increased inflammation. METHODS: In this review, we will discuss the utility and shortcomings of pharmacologic AD treatment strategies focused on inflammatory pathways, applied alone or as an adjuvant component to current AD therapies. RESULTS: Mechanisms of cytokine actions on behavior involve activation of inflammatory pathways in the brain, resulting in changes of neurotransmitter metabolism, neuroendocrine function, and neuronal plasticity. Selective serotonin reuptake inhibitors exhibit the most beneficial effects in restraining the inflammation markers in depression. Different anti-inflammatory agents exhibit AD effects via modulating neurotransmitter systems, neuroplasticity markers and glucocorticoid receptor signaling. Anti-inflammatory add-on therapy in depression highlights such treatment as a candidate for enhancement strategy in patients with moderate-to-severe depression. CONCLUSION: The interactions between the immune system and CNS are not only involved in shaping behavior, but also in responding to therapeutics. Even though, substantial evidence from animal and human research support a beneficial effect of anti-inflammatory add-on therapy in depression, further research with special attention on safety, particularly during prolonged periods of antiinflammatory co-treatments, is required.

5 Review Oxidative and nitrosative stress pathways in the brain of socially isolated adult male rats demonstrating depressive- and anxiety-like symptoms. 2017

Filipović, Dragana / Todorović, Nevena / Bernardi, Rick E / Gass, Peter. ·Laboratory of Molecular Biology and Endocrinology, Institute of Nuclear Sciences "Vinča", University of Belgrade, PO Box 522-090, 11001, Belgrade, Serbia. dragana@vinca.rs. · Laboratory of Molecular Biology and Endocrinology, Institute of Nuclear Sciences "Vinča", University of Belgrade, PO Box 522-090, 11001, Belgrade, Serbia. · Institute of Psychopharmacology, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159, Mannheim, Germany. · Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, 68159, Mannheim, Germany. ·Brain Struct Funct · Pubmed #27033097.

ABSTRACT: Various stressors may disrupt the redox homeostasis of an organism by causing oxidative and nitrosative stress that may activate stressor-specific pathways and provoke specific responses. Chronic social isolation (CSIS) represents a mild chronic stress that evokes a variety of neurobehavioral changes in rats similar to those observed in people with psychiatric disorders, including depression. Most rodent studies have focused on the effect of social isolation during weaning or adolescence, while its effect in adult rats has not been extensively examined. In this review, we discuss the current knowledge regarding the involvement of oxidative/nitrosative stress pathways in the prefrontal cortex and hippocampus of adult male rats exposed to CSIS, focusing on hypothalamic-pituitary-adrenocortical (HPA) axis activity, behavior parameters, antioxidative defense systems, stress signaling mediated by nuclear factor-kappa B (NF-κB), and mitochondria-related proapoptotic signaling. Although increased concentrations of corticosterone (CORT) have been shown to induce oxidative and nitrosative stress, we suggest a mechanism underlying the glucocorticoid paradox whereby a state of oxidative/nitrosative stress may exist under basal CORT levels. This review also highlights the differential susceptibility of prefrontal cortex and hippocampus to oxidative stress following CSIS and suggests a possible cellular pathway of stress tolerance that preserves the hippocampus from molecular damage and apoptosis. The differential regulation of the transcriptional factor NF-κB, and the enzymes inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) following CSIS may be one functional difference between the response of the prefrontal cortex and hippocampus, thus identifying potentially relevant targets for antidepressant treatment.

6 Review Molecular Mechanism and Clinical Relevance of Ketamine as Rapid-Acting Antidepressant. 2016

Pešić, Vesna / Petrović, Jelena / M Jukić, Marin. ·Department of Physiology, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. · Department of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden. ·Drug Dev Res · Pubmed #27546787.

ABSTRACT: Preclinical Research The emergence of rapid-acting antidepressants such as ketamine has motivated studies aiming to reveal the molecular mechanism of the ketamine antidepressant effect and to enable the clinical application of rapid-acting antidepressants. Here, we provide an overview of studies addressing the antidepressant effects of ketamine in depressed patients and animal models of depression and we compare the reduction of depressive symptoms in humans with the reduction in immobility time in the forced swim test in rodents after acute ketamine treatment. We also discuss different theories and potential biochemical pathways involved in the rapid antidepressant response to ketamine including the modulation of glutamatergic neurotransmission and intracellular hub-kinase activation. Finally, we summarize recent brain-region specific studies and we suggest that the activation of the ventral hippocampus-medial prefrontal cortex-dorsal raphae nuclei (vHC-mPFC-DRN) neuronal pathway may mediate the antidepressant effect of ketamine. Although substantial progress has been made, further brain-region specific animal studies and longitudinal clinical trials are necessary for the understanding and successful application of novel rapid-acting antidepressants. Drug Dev Res 77 : 414-422, 2016. © 2016 Wiley Periodicals, Inc.

7 Review Biomarkers for Major Depressive Disorder: Economic Considerations. 2016

Bogavac-Stanojevic, Natasa / Lakic, Dragana. ·Faculty of Pharmacy, Department of Medical Biochemistry, University of Belgrade, Belgrade, Serbia. · Faculty of Pharmacy, Department of Social Pharmacy and Pharmacy Legislation, University of Belgrade, Belgrade, Serbia. ·Drug Dev Res · Pubmed #27546547.

ABSTRACT: Preclinical Research Major depressive disorder (MDD) is a major psychiatric illness and it is predicted to be the second leading cause of disability by 2020 with a lifetime prevalence of about 13%. Selective serotonin reuptake inhibitors (SSRIs) are the most commonly used therapeutic class for MDD. However, response to SSRI treatment varies considerably between patients. Biomarkers of treatment response may enable clinicians to target the appropriate drug for each patient. Biomarkers need to have accuracy in real life, sensitivity, specificity, and relevance to depression. Introduction of MDD biomarkers into the health care system can increase the overall cost of clinical diagnosis of patients. Because of that, decisions to allocate health research funding must be based on drug effectiveness and cost-effectiveness. The assessment of MDD biomarkers should include reliable evidence of associated drug effectiveness, adverse events and consequences (reduced productivity and quality of life, disability) and effectiveness of alternative approaches, other drug classes or behavioral or alternative therapies. In addition, all the variables included in an economic model (probabilities, outcomes, and costs) should be based on reliable evidence gained from the literature-ideally meta-analyses-and the evidence should also be determined by informed and specific expert opinion. Early assessment can guide decisions about whether or not to continue test development, and ideally to optimize the process. Drug Dev Res 77 : 374-378, 2016. © 2016 Wiley Periodicals, Inc.

8 Review Meta-analysis of the changes in correlations between depression instruments used in longitudinal studies. 2016

Bukumiric, Zoran / Starcevic, Vladan / Stanisavljevic, Dejana / Marinkovic, Jelena / Milic, Natasa / Djukic-Dejanovic, Slavica / Janjic, Vladimir / Corac, Aleksandar / Ilic, Aleksandra / Kostic, Mirjana / Nikolic, Ivan / Trajkovic, Goran. ·Institute for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Serbia. Electronic address: zoran.bukumiric@mfub.bg.ac.rs. · University of Sydney, Sydney Medical School - Nepean, Discipline of Psychiatry, Sydney, Australia. · Institute for Medical Statistics and Informatics, Faculty of Medicine, University of Belgrade, Serbia. · Department of Psychiatry, Faculty of Medical Sciences, University of Kragujevac, Serbia. · Department of Public Health, Medical Faculty, University of Pristina, Kosovska Mitrovica, Serbia. ·J Affect Disord · Pubmed #26606717.

ABSTRACT: BACKGROUND: Correlations between instruments measuring the same construct reflect their concurrent validity. Little is known about changes in correlations between such instruments employed in studies with repeated assessment. The aim of this meta-analysis was to examine the changes in correlations between depression instruments in the course of longitudinal studies. METHODS: A literature search was conducted using MEDLINE and PsycINFO for the period from 1960 to 2013. The total number of collected articles was 3723, of which 61 were included. Three meta-analyses were performed for the changes in correlations between each pair of the three depression scales: Hamilton Rating Scale for Depression (HAMD), Montgomery-Asberg Depression Rating Scale (MADRS) and Beck Depression Inventory (BDI). The effect size in these meta-analyses was obtained by the z-transformation of correlation coefficients. RESULTS: Correlations between depression scales increased over time in 52 studies. Significant changes in correlation coefficients were found for correlations between HAMD and BDI (p<0.001) and for correlations between HAMD and MADRS (p<0.001). An increase in correlations between the scales was associated with a decrease in depression scores and increase in their variability. LIMITATIONS: Univariable and multivariable meta-regression models were not obtained in all three meta-analyses because of the lack of data. CONCLUSIONS: A finding that correlations between depression instruments tended to increase over time has significant implications for assessment of the concurrent validity of these instruments. In longitudinal designs it is important to estimate correlations between depression scales over time because different thresholds for scale correlations indicate acceptable concurrent validity at different times.

9 Review Psychiatric comorbidity in the treatment of patients with inflammatory bowel disease. 2014

Filipovic, Branislav R / Filipovic, Branka F. ·Branislav R Filipovic, Faculty of Medicine, Institute of Anatomy "Niko Miljanic", 11000 Belgrade, Serbia. ·World J Gastroenterol · Pubmed #24707138.

ABSTRACT: Ulcerative colitis and Crohn's disease, commonly known as inflammatory bowel disease (IBD), draw attention from specialists of various disorders, including gastroenterology, psychiatry, and radiology. The involvement of a cortical influence in the brain-gut axis as well as the interaction of the hypothalamic-pituitary-adrenal axis and the peripheral nervous system provide an initial explanation of the psychological symptoms associated with IBD. The involvement of structures the limbic system, such as the anterior cingulate cortex, the prefrontal cortex, and the amygdala, paves the way for the discovery of the mechanisms underlying depression depression, anxiety, alexithymia, personality traits, and other psychological impairments following the onset of IBD. Psychiatric therapy in IBD patients is almost as important as the gastroenterological approach and consists of pharmacological treatment and psychotherapy. Neither of the available psychiatric treatment methods is considered the golden standard because both methods have side effects, and psychotropic medication can provoke the worsening of IBD symptoms. Thus, both approaches must be applied with awareness of the possibility of side effects. We suggest that psychiatrists and gastroenterologists work together to reach a consensus on IBD therapy to ensure success and to reduce side effects and relapse to the lowest possible rates.

10 Review Are antidepressants effective in quality of life improvement among children and adolescents? A systematic review. 2014

Stevanovic, Dejan / Tadic, Ivana / Knez, Rajna. ·1 Department of Psychiatry, General Hospital Sombor, Sombor, Serbia. · 2 Department of Social Pharmacy and Pharmacy Legislation, Faculty of Pharmacy, University of Belgrade, Belgrade, Serbia. · 3 Department of Psychiatry, Rijeka University Hospital Centre, Rijeka, Croatia. ·CNS Spectr · Pubmed #24029410.

ABSTRACT: There is some evidence indicating that psychotropic medications might lead to health-related quality of life (QOL) improvements among children and adolescents with psychiatric disorders. The aim of this systematic review is to assess evidence regarding whether antidepressant treatment improves QOL among children and adolescents with depressive or anxiety disorders. A comprehensive search resulted in 5 clinical trials to be included in this review: 4 trials with major depressive disorder (MDD) and 1 trial with social anxiety disorder (SAD). In one MDD trial, fluoxetine combined with cognitive behavior therapy (CBT) significantly improved QOL compared to fluoxetine or CBT alone (effect sizes were 0.53 and 0.69, respectively). In 2 combined trials, sertraline alone significantly improved QOL among adolescents with MDD (effect size was 0.29), but not among children with MDD. Essentially, it was observed that antidepressants in these trials had minor positive effects on QOL improvement, which were lower than their potential to improve depressive symptoms. Although fluoxetine with CBT or sertraline monotherapy were shown to have some potential to improve QOL, this systematic review found inconclusive evidence that antidepressant treatments improve QOL among children and adolescents with depressive or anxiety disorders. More research is required, considering that QOL is currently under-evaluated in clinical trials with antidepressants among children and adolescents and available trials have limited methodological quality when reporting QOL data.

11 Review Pharmacological modulation of HPA axis in depression - new avenues for potential therapeutic benefits. 2013

Maric, Nadja P / Adzic, Miroslav. ·Clinic for Psychiatry, University Clinical Centre of Serbia, Pasterova 2, 11000 Belgrade, Serbia, nadjamaric@yahoo.com. ·Psychiatr Danub · Pubmed #24048401.

ABSTRACT: One of the most consistent biological findings in major depression (MDD) is the altered activity of the hypothalamic-pituitary-adrenal (HPA) axis. It is not surprising that glucocorticoid receptor (GR), the common mechanism for stress-related changes in brain function, is a potential target of antidepressant drugs and therapies. All effective antidepressant treatments should trigger and maintain GR-related cellular processes necessary for recovery from MDD. Classic antidepressants act indirectly, by affecting the dynamic interplay between serotonin neurotransmission and HPA. On the other hand, certain compounds acting at supra-hypothalamic, HPA axis, glucocorticoid receptors, and post-receptor levels are being considered as new therapeutic options with the potential to modulate the aforementioned system in affective disorders directly. Different classes of drugs pharmacologically modify the HPA axis. This article summarizes the efficacy of classic antidepressants, as well as drugs classified as "antiglucocorticoids" (GR agonists, GR antagonists, dehydroepiandrosterone- DHEA, steroid synthesis inhibitors drugs, etc) in their capacity to heal glucocorticoid-mediated damage in depression. New avenues investigating the potential therapeutic benefits of antiglucocorticoids in affective disorders are at the proof-of-concept stage and future developments in this area deserve the full attention of psychiatrists and neuroscientists, as the current pharmacological treatment of MDD is far from perfect.

12 Review Repetitive transcranial magnetic stimulation in bipolar depression: another puzzle of manic switch? 2013

Krstić, Jelena / Ilić, Tihomir V. ·Psychiatric Hospital, Clinical Hospital Center "Dr Dragiha MiBoviC"- Dedinje, Belgrade, Serbia. ·Vojnosanit Pregl · Pubmed #23885527.

ABSTRACT: -- No abstract --

13 Review Preoperative assessment and management of patient with psychiatric comorbidity. 2011

Milenović, Miodrag / Kalezić, Nevena / Simić, Dusica / Dimitrijević, Draga / Marković, Dejan / Dimitrijević, Ivan. ·Center for Anesthesia, Clinical Center of Serbia, Belgrade. ·Acta Chir Iugosl · Pubmed #21879664.

ABSTRACT: This article explains the most frequent psychiatric disorders such as co-morbidity in the acute surgical treatment, along with its position and importance for the surgical procedure. Besides basic features of these disorders, epidemiology and clinical expression, this article holds the latest therapeutic approach, side effects, toxicity and drug interactions, during the surgical procedure. Frequent postoperative problems, delirium, and postoperative cognitive disorders are noted in these patients. To avoid these complications, it is recommended to use a mini-mental score examination to re-evaluate the decision and indication for high risk surgery patient.

14 Review Neuroanatomical correlates of depression and apathy in Parkinson's disease: magnetic resonance imaging studies. 2011

Kostić, Vladimir S / Filippi, Massimo. ·Department of Neurology, School of Medicine, University of Belgrade, Belgrade, Serbia. vladimir.s.kostic@gmail.com ·J Neurol Sci · Pubmed #21684552.

ABSTRACT: Depression and apathy are among the most common neuropsychiatric disturbances in Parkinson's disease (PD), and among the most important factors associated with a poor quality of life. However, their neural bases remain unclear. The results of the magnetic resonance imaging (MRI) studies on depression in PD differ dramatically. Some of them proposed a role of morphologic changes in the mediodorsal thalamus. In contrast to previous voxel-based morphometry (VBM) data, our study did not confirm a decrease in gray matter (GM) density in any brain region of depressed PD patients. Instead, a more severe white matter (WM) loss in the right frontal lobe was found, including the anterior cingulate bundle and the inferior orbitofrontal (OF) region. We suggested that the negative correlation between the severity of depression and WM density in the right OF region reinforces the hypothesis of depression in PD as a "disconnection syndrome". Only one MRI study using VBM found that high apathy scores correlated with low GM density values in the right (posterior) cingulate gyrus and the bilateral inferior frontal gyrus, in line with the findings in Alzheimer's disease and elderly adults with major depression.

15 Review Critical review of studies on quality of life in psychiatric patients published in Serbian medical journals from 2000 to 2009. 2010

Jašović-Gašić, Miroslava / Lačković, Maja / Dunjić-Kostić, Bojana / Pantović, Maja M / Cvetić, Tijana / Damjanović, Aleksandar / Vuković, Olivera / Ceković, Jovana / Jovanović, Aleksandar A. ·University Clinical Center of Serbia, Pasterova 2, 11000 Belgrade, Serbia. mjasovicgasic0@gmail.com ·Psychiatr Danub · Pubmed #21169887.

ABSTRACT: BACKGROUND: Quality of life (QoL) is known to be indicative of the level of social functioning in mental health patients. However, the research on QoL, in the field of psychiatry, is not as comprehensive as it is in other domains of medicine. The aim of this study was to review the research evidence on QoL in psychiatric patients, published in Serbian medical journals during the last decade. MATERIAL AND METHODS: The research data from studies on quality of life in psychiatric patients, published in Serbian medical journals from 2000 to 2009, were obtained by searching the databases Kobson and Medline. RESULTS: We found eight studies on QoL in psychiatric patients published in Serbian medical journals from 2000 to 2009. The reviewed articles were focused on the comparison of QoL between psychiatric patients and healthy controls, or somatic patients, the research on the relationship of QoL and general psychopathology, and the research on QoL and medical treatment. CONCLUSIONS: QoL in patients suffering from mental disorders, as the outcome variable, is of a paramount interest in the follow-up treatment studies in psychiatry targeting critical issues of mental illness management strategies. QoL of psychiatric patients in Serbia is still under-researched, and it would be important to measure QoL from both a patient's and observer's (i.e. family members, friends, nursing staff, mental health professionals, etc.) perspective, in the context of social, economic, and cultural background of the patient. In the future, the studies on QoL in psychiatric patients in Serbia should also rely on "disease specific" assessment scales, which would consider particular aspects of psychopathology, and eventually follow up longitudinal course of mental illness, treatment outcome, and recovery.

16 Review Transcranial sonography in depression. 2010

Mijajlovic, Milija D. ·Institute of Neurology, Clinical Center of Serbia, School of Medicine University of Belgrade, Serbia. ·Int Rev Neurobiol · Pubmed #20692507.

ABSTRACT: Transcranial sonography, which displays tissue echogenicity of the brain through the intact skull, reveals reduced echogenicity of the brainstem raphe (BR) as a characteristic finding in unipolar depression and in depression associated with Parkinson's or Wilson's disease, but in general not in healthy adults, bipolar affective disorders, schizophrenia, multiple sclerosis with depression, or Parkinson's disease without concomitant depression. The reason for the reduced echogenicity of the BR is not entirely clear. Magnetic resonance imaging investigations, however, provide evidence that the signal alteration may be caused by a modification of tissue cell density, the interstitial matrix composition, or an alteration of fiber tracts integrity. An involvement of the basal limbic system in the pathogenesis of unipolar depression and depression associated with certain neurodegenerative diseases is assumed.

17 Review Contemporary framework for alcohol craving. 2008

Vuković, Olivera / Cvetić, Tijana / Zebić, Mirjana / Marić, Nadja / Britvić, Dubravka / Damjanović, Aleksandar / Jasović-Gasić, Miroslava. ·Institute of Psychiatry, Clinical Center of Serbia, Serbia. ·Psychiatr Danub · Pubmed #19011591.

ABSTRACT: OBJECTIVE: Fifty years ago, craving was defined as an "urgent and overpowering desire, or irresistible impulse", but subsequently, craving definitions have been modified by many authors and no unique definition of this phenomena, or a consensus in regards to its manifestation and significance exists. This review discusses the contemporary views of alcohol craving. Issues such as definition and different types, dynamics of craving, its mediators and moderators and clinical correlations are explored. SUBJECTS AND METHODS: We focused on the literature search (MEDLINE, PSYCHLIT, and EMBASE) and new findings in the addiction field, especially paying attention on the study of craving. FINDINGS: There is growing evidence to suggest that craving is associated with different aspects of addiction (i.e. withdrawal, relapse) and clinical characteristics such as depression and anxiety. These different phenomena contribute individual differences in intensity, frequency and types of craving. At present, there are several different models to better describe the complexity of craving. CONCLUSIONS: Craving is not an exact, precisely measurable value but it is rather an uncertain, descriptive phenomenon. Further research (biological, sociological and psychological) should be orientated primarily toward exploration of the relationship between environmental factors and personality variables and craving and its maintenance, with special attention to gender differences.

18 Review Excessive internet use and depressive disorders. 2008

Mihajlović, Goran / Hinić, Darko / Damjanović, Aleksandar / Gajić, Tomislav / Dukić-Dejanović, Slavica. ·Psychiatry Clinic, Faculty of Medicine, University of Kragujevac, Serbia. ·Psychiatr Danub · Pubmed #18376325.

ABSTRACT: Recent studies of Internet influence on behavioural disorders of its users, have created quite a polarised ambience. On the one hand, there are those who believe that the Internet is a new better medium for enabling various patterns of communication and social relations. On the other hand, others maintain that Internet use can lead to social isolation and other forms of psychological disorders, for an example depression. The aim of this work is a review of research attempts to confirm a connection between increased Internet use and psychological disorders, in the first place, depression. The number of studies on this subject is not very great thus far. This is mainly because depression and similar disorders are serious distorsions in basic psychological processes; this suggests how difficult it may be to work with such examinees, and how complex it may appear to distinguish etiological factors. These facts do not lessen the importance of the aim itself, i.e. defining potential consequences of excessive Internet use when it comes to psychological wellbeing, since the Internet is expected to become a basic form of social interaction in the near future, and consequently one of the major factors of socialisation and constitution of one's psychological identity. Due to that fact, the aim of this work is to indicate methodological and conceptual flaws of the studies which have attempted to make a connection between mood disorders and the Internet, so as to establish the base for future studies of the psychological consequences of Internet development.

19 Clinical Trial The efficacy of fluoxetine in BMS-A cross-over study. 2018

Zoric, Bojana / Jankovic, Ljiljana / Kuzmanovic Pficer, Jovana / Zidverc-Trajkovic, Jasna / Mijajlovic, Milija / Stanimirovic, Dragan. ·Department of Periodontology and Oral Medicine, School of Dental Medicine, University of Belgrade, Belgrade, Serbia. · Department for Medical Statistics and Informatics, School of Dental Medicine, University of Belgrade, Belgrade, Serbia. · Institute of Neurology, Clinical Center of Serbia, Belgrade, Serbia. ·Gerodontology · Pubmed #29575009.

ABSTRACT: BACKGROUND: Burning mouth syndrome (BMS) is an intraoral burning or dysaesthetic sensation, recurring daily for more than two hours during the period longer than 3 months. The objective was to evaluate and analyse the efficacy of serotonin reuptake inhibitor fluoxetine on psychological factors, as well as on pain in participants with BMS. METHODS: In a 6-month study, 100 participants with primary and secondary BMS were divided into two groups-fluoxetine and control (placebo) and examined by the dentist and the neurologist. Depression and anxiety were estimated by Hamilton Scale for Depression (HAM-D) and Anxiety (HAM-A) and Beck Depression Inventory (BDI) and the pain intensity by visual analogue scale (VAS). RESULTS: Mean age of the participants was 60.33 in fluoxetine group and 67.4 in control group. Most of the participants were female-74% in the fluoxetine and 78% in the control group. Statistical difference between the fluoxetine and the control group was found in HAM-D results (P < .05). Values of other scales and VAS decreased significantly after the therapy in both groups (P < .05). CONCLUSIONS: Our trial results indicate that fluoxetine therapy not only improves the psychological status of participants with BMS but also fluoxetine decreases the intensity of pain in these patients.

20 Clinical Trial Improvement of Glycemic Control in Insulin-Dependent Diabetics with Depression by Concomitant Treatment with Antidepressants. 2016

Radojkovic, Jana / Sikanic, Natasa / Bukumiric, Zoran / Tadic, Marijana / Kostic, Nada / Babic, Rade. ·Department of Clinical Endocrinology, Clinical Center "Dr Dragisa Misovic", Belgrade, Serbia. · Department of Clinical Psychiatry, Clinical Center "Dr Dragisa Misovic", Belgrade, Serbia. · Department of Medical Statistics, University School of Medicine, Belgrade, Serbia. · Department of Internal Medicine, University School of Medicine, Belgrade, Serbia. ·Med Sci Monit · Pubmed #27329213.

ABSTRACT: BACKGROUND It is still disputable whether negative effects of comorbid depression in diabetics can be diminished by successful treatment of depression. The primary aim of this study was to assess whether addition of antidepressants to existing insulin treatment would further improve glycemic control in these patients. A secondary objective was to assess whether such treatment impairs their lipid and inflammatory status. MATERIAL AND METHODS Total of 192 patients with poorly controlled diabetes (defined as HbA1c ≥8%) in the absence of any uncontrolled medical condition entered the 6-month run-in phase with optimization of diabetic therapy. Depression status was screened at the end of this phase by BDI-II depression testing. Patients with BDI-II ≥14 and psychiatric confirmation of depression (58 patients) entered the 6-month interventional phase with SSRI class antidepressants. RESULTS Fifty patients completed the study. During the run-in phase, HbA1c dropped from 10.0±1.8% to 8.5±1.2% (p<0.001), and during the interventional phase it dropped from 8.5±1.2% to 7.7±0.7% (p<0.001). BDI-II scores improved significantly from 30.4±13.2 to 23.5±11.0 (p=0.02) during the interventional phase. A positive linear correlation between improvement in depression scale and improvement in glycemic control was observed (R²=0.139, p=0.008). Lipid profile and inflammatory status did not change significantly during the interventional phase. CONCLUSIONS Patients with poorly controlled diabetes and comorbid depression might benefit from screening and treatment of depression with SSRI antidepressants by achieving an incremental effect on glycoregulation. This therapy did not have any adverse effects on lipid profile or inflammatory status.

21 Clinical Trial Gallbladder emptying in patients with major depression: a case series. 2011

Andjelkovic, M / Jovanovic, D B / Zdravkovic, N / Jankovic, S M. ·Dom Zdravlja, Kragujevac, Serbia. ·Pharmacopsychiatry · Pubmed #21751125.

ABSTRACT: INTRODUCTION: Although several adverse effects of antidepressants on the gastrointestinal tract have been described (bleeding, constipation, dolichocolon), their influence on gallbladder motility was not investigated.The aim of our study was to investigate the effects of selected antidepressants on gallbladder emptying in patients with major depression. METHODS: The study was set up as an open clinical trial, with the same intervention (ingestion of test meal provoking gallbladder emptying) undertaken in 112 patients with major depression. There were 30 patients not taking antidepressants (the control group), 25 patients taking amitriptyline, 30 patients taking maprotiline, and 27 patients taking fluoxetine. The volume of gallbladder in the study patients was measured by ultrasonography before the test meal, and 15, 30, 45 and 60 min after the meal. RESULTS: 1 h after ingestion of the study meal, the amitriptyline group showed incomplete gallbladder emptying (F=10.829, df=3, p=0.000; mean residual volume 11.0±6.1 mL), while in the control, maprotiline and fluoxetine groups emptying of gallbladder was complete (mean residual volumes 5.0±3.3 mL, 5.6±3.7 mL and 5.7±2.3 mL, respectively). DISCUSSION: In patients with cholecystitis, it would be wise to use antidepressants which do not impair gallbladder emptying, like maprotiline or fluoxetine, and to avoid amitriptyline.

22 Clinical Trial Efficacy, tolerability and safety of tianeptine in special populations of depressive patients. 2009

Vuković, Olivera / Marić, Nadja P / Britvić, Dubravka / Cvetić, Tijana / Damjanović, Aleksandar / Prostran, Milica / Jasović-Gasić, Miroslava. ·Institute of Psychiatry, Clinical Centre of Serbia, 11000 Belgrade, Pasterova 2, Serbia. olivukovic@gmail.com ·Psychiatr Danub · Pubmed #19556948.

ABSTRACT: BACKGROUND: Tianeptine, a new generation antidepressant, possesses a unique mechanism of antidepressive action and has a specific pharmacokinetic profile. The aim of this study was to determine the efficacy, tolerability and safety of tianeptine in a "fragile" population of depressive patients: (1) a group of elderly patients and (2) a group with comorbid alcohol addiction. SUBJECTS AND METHODS: This was an open multicentric eight-week study of tianeptine efficacy, tolerability and safety including patients with mild to moderate depression (DSM-IV), age > or =55 years (group 1; n=45) or with comorbid alcohol addiction (group 2; n=32). Assessments was made with the following rating scales; MADRS, HAM-A and CGI for efficacy and DESS for tolerability. RESULTS: After eight-week tianeptine therapy, remission (MADRS < or =12) was established in 51.1% and 84.4% patients, respectively. On day 7, the therapy led to a significant decrease of MADRS. On endpoint, there were significant differences on HAM-A, CGI-I and CGI-S scores (p<0.01). No adverse effects with frequency > or = 10%, were registered. A lower tolerability of tianeptine was registered in a group of elderly (nausea 4.5%, leg fatigue 4.4%, irritability 2.2%, bursts of crying and sadness 2.2%), while only 3.1% depressive patients with comorbid alcohol addiction had dizziness. CONCLUSION: This is the first clinical study to evaluate tolerability, efficacy and safety of tianeptine in a special population of depressive patients in the region. The study showed that tianeptine had good efficacy in treatment of mild to moderate forms of depression in special populations of depressive patients (elderly population and patients with comorbid alcohol addiction). The drug was well tolerated.

23 Article Brain Sub/Region-Specific Effects of Olanzapine on c-Fos Expression of Chronically Socially Isolated Rats. 2019

Stanisavljević, Andrijana / Perić, Ivana / Gass, Peter / Inta, Dragos / Lang, Undine E / Borgwardt, Stefan / Filipović, Dragana. ·Vinča Institute of Nuclear Sciences, Laboratory for Molecular Biology and Endocrinology, University of Belgrade, Serbia. · Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. · Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychiatry (UPK), University of Basel, Switzerland. · Department of Psychiatry (UPK), University of Basel, Switzerland. · Vinča Institute of Nuclear Sciences, Laboratory for Molecular Biology and Endocrinology, University of Belgrade, Serbia. Electronic address: dragana@vinca.rs. ·Neuroscience · Pubmed #30458222.

ABSTRACT: Olanzapine (Olz) is an atypical antipsychotic used to treat depression, anxiety and schizophrenia, which can be caused by chronic psychosocial stress. c-Fos protein expression has been used as an indirect marker of neuronal activity in response to various forms of stress or pharmacological treatments. We examined the effects of a 3-week treatment of Olz (7.5 mg/kg/day) on c-Fos protein expression in stress-relevant brain sub/regions, its relationship with isolation-induced behavioral changes, and potential sites of Olz action on control and male rats exposed to 6 weeks of chronic social isolation (CSIS), an animal model of depression. Olz treatment reversed depression- and anxiety-like behaviors induced by CSIS and suppressed a CSIS-induced increase in the number of c-Fos-positive cells in subregions of the dorsal hippocampus, ventral (v) DG, retrosplenial cortex, and medial prefrontal cortex. In contrast, no change in c-Fos expression was seen in the CA3v, amygdala and thalamic, hypothalamic or striatal subregions in Olz-treated CSIS rats, suggesting different brain sub/regions' susceptibility to Olz. An increased number of c-Fos-positive cells in the CA1v, amygdala and thalamic, hypothalamic and striatal subregions in controls as well as in the CA1v and subregion of the hypothalamus and nucleus accumbens in Olz-treated CSIS rats was found. Results suggest the activation of brain sub/regions following CSIS that may be involved in depressive and anxiety-like behaviors. Olz treatment showed region-specific effects on neuronal activation. Our data contribute to a better understanding of the mechanisms underlying the CSIS response and potential brain targets of Olz in socially isolated rats.

24 Article Subregion-specific Protective Effects of Fluoxetine and Clozapine on Parvalbumin Expression in Medial Prefrontal Cortex of Chronically Isolated Rats. 2019

Todorović, Nevena / Mićić, Bojana / Schwirtlich, Marija / Stevanović, Milena / Filipović, Dragana. ·Laboratory of Molecular Biology and Endocrinology, Institute of Nuclear Sciences "Vinča", University of Belgrade, Serbia. · Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia. · Institute of Molecular Genetics and Genetic Engineering, University of Belgrade, Belgrade, Serbia; University of Belgrade, Faculty of Biology, Belgrade, Serbia; Serbian Academy of Sciences and Arts, Belgrade, Serbia. · Laboratory of Molecular Biology and Endocrinology, Institute of Nuclear Sciences "Vinča", University of Belgrade, Serbia. Electronic address: http://www.vinca.rs. ·Neuroscience · Pubmed #30448452.

ABSTRACT: Dysregulation of GABAergic system is becoming increasingly associated with depression, psychiatric disorder that imposes severe clinical, social and economic burden. Special attention is paid to the fast-spiking parvalbumin-positive (PV+) interneurons, GABAergic neurons which are highly susceptible to redox dysregulation and oxidative stress and implicated in a variety of psychiatric diseases. Here we analyzed the number of PV+ and cleaved caspase-3-positive (CC3+) cells in the rat medial prefrontal cortical (mPFC) subregions following chronic social isolation (CSIS), an animal model of depression and schizophrenia. Also, we examined potential protective effects of antidepressant fluoxetine (FLX) and atypical antipsychotic clozapine (CLZ) on the number of these cells in mPFC subregions, when applied parallel with CSIS in doses that correspond to therapeutically effective ones in patients. Immunofluorescence analysis revealed decreased number of PV+ cells in cingulate cortex area 1, prelimbic area (PrL), infralimbic area (IL) and dorsal peduncular cortex of the mPFC in isolated rats, which coincided with depressive- and anxiety-like behaviors. In addition, CSIS-induced increase in the number of CC3+ cells was detected in aforementioned subregions of mPFC. Treatments with either FLX or CLZ prevented behavioral changes, decrease in PV+ and increase in CC3+ cell numbers in PrL and IL subregions in isolated rats. These results indicate the importance of intact GABAergic signaling in these areas for resistance against CSIS-induced behavioral changes, as well as subregion-specific protective effects of FLX and CLZ in mPFC of CSIS rats.

25 Article Tianeptine antagonizes the reduction of PV+ and GAD67 cells number in dorsal hippocampus of socially isolated rats. 2019

Perić, Ivana / Stanisavljević, Andrijana / Inta, Dragos / Gass, Peter / Lang, Undine E / Borgwardt, Stefan / Filipović, Dragana. ·Vinča Institute of Nuclear Sciences, Laboratory for molecular biology and endocrinology, University of Belgrade, Serbia. · Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany; Department of Psychiatry (UPK), University of Basel, Switzerland. · Department of Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. · Department of Psychiatry (UPK), University of Basel, Switzerland. · Vinča Institute of Nuclear Sciences, Laboratory for molecular biology and endocrinology, University of Belgrade, Serbia. Electronic address: dragana@vinca.rs. ·Prog Neuropsychopharmacol Biol Psychiatry · Pubmed #30367961.

ABSTRACT: Adult male rats exposed to chronic social isolation (CSIS) show depressive- and anxiety-like behaviors and reduce the numbers of parvalbumin-positive (PV+) interneurons in the dorsal hippocampus. We aimed to determine whether tianeptine (Tian), administered during the last three weeks of a six-week-social isolation (10 mg/kg/day), may reverse CSIS-induced behavioral changes and antagonize the CSIS-induced reduction in the number of PV+ interneurons. We also studied whether Tian affects the GABA-producing enzyme GAD67+ cells, in Stratum Oriens (SO), Stratum Pyramidale (SP), Stratum Radiatum (SR) and Stratum Lacunosum Moleculare (LM) of CA1-3, as well as in molecular layer-granule cell layer (ML-GCL) and Hilus (H) of the dentate gyrus (DG). CSIS-induced reduction in the number of PV+ cells was layer/subregion-specific with the greatest decrease in SO of CA2. Reduction in the number of PV+ cells was significantly higher than GAD67+ cells, indicating that PV+ cells are the main target following CSIS. Tian reversed CSIS-induced behavior phenotype and antagonized the reduction in the number of PV+ and GAD67+ cells in all subregions. In controls, Tian led to an increase in the number of PV+ and GAD67+ cells in SP of all subregions and PV+ interneurons in ML-GCL of DG, while treatment during CSIS, compared to CSIS alone, resulted with an increase of PV+ interneurons in SO and SP CA1, SP CA2/CA3 and ML-GCL DG with simultaneous increase in GAD67+ cells in all CA1, LM CA2, SO/SR/LM CA3. Data show that Tian offers protection from CSIS via modulation of the dorsal hippocampal GABAergic system.