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Depression: HELP
Articles from Iowa
Based on 444 articles published since 2008

These are the 444 published articles about Depression that originated from Iowa during 2008-2019.
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14 · 15 · 16 · 17 · 18
1 Guideline Interventions to Prevent Perinatal Depression: US Preventive Services Task Force Recommendation Statement. 2019

Anonymous3491079 / Curry, Susan J / Krist, Alex H / Owens, Douglas K / Barry, Michael J / Caughey, Aaron B / Davidson, Karina W / Doubeni, Chyke A / Epling, John W / Grossman, David C / Kemper, Alex R / Kubik, Martha / Landefeld, C Seth / Mangione, Carol M / Silverstein, Michael / Simon, Melissa A / Tseng, Chien-Wen / Wong, John B. ·University of Iowa, Iowa City. · Fairfax Family Practice Residency, Fairfax, Virginia. · Virginia Commonwealth University, Richmond. · Veterans Affairs Palo Alto Health Care System, Palo Alto, California. · Stanford University, Stanford, California. · Harvard Medical School, Boston, Massachusetts. · Oregon Health & Science University, Portland. · Feinstein Institute for Medical Research at Northwell Health, Manhasset, New York. · University of Pennsylvania, Philadelphia. · Virginia Tech Carilion School of Medicine, Roanoke. · Kaiser Permanente Washington Health Research Institute, Seattle. · Nationwide Children's Hospital, Columbus, Ohio. · Temple University, Philadelphia, Pennsylvania. · University of Alabama at Birmingham. · University of California, Los Angeles. · Boston University, Boston, Massachusetts. · Northwestern University, Evanston, Illinois. · University of Hawaii, Honolulu. · Pacific Health Research and Education Institute, Honolulu, Hawaii. · Tufts University, Medford, Massachusetts. ·JAMA · Pubmed #30747971.

ABSTRACT: Importance: Perinatal depression, which is the occurrence of a depressive disorder during pregnancy or following childbirth, affects as many as 1 in 7 women and is one of the most common complications of pregnancy and the postpartum period. It is well established that perinatal depression can result in adverse short- and long-term effects on both the woman and child. Objective: To issue a new US Preventive Services Task Force (USPSTF) recommendation on interventions to prevent perinatal depression. Evidence Review: The USPSTF reviewed the evidence on the benefits and harms of preventive interventions for perinatal depression in pregnant or postpartum women or their children. The USPSTF reviewed contextual information on the accuracy of tools used to identify women at increased risk of perinatal depression and the most effective timing for preventive interventions. Interventions reviewed included counseling, health system interventions, physical activity, education, supportive interventions, and other behavioral interventions, such as infant sleep training and expressive writing. Pharmacological approaches included the use of nortriptyline, sertraline, and omega-3 fatty acids. Findings: The USPSTF found convincing evidence that counseling interventions, such as cognitive behavioral therapy and interpersonal therapy, are effective in preventing perinatal depression. Women with a history of depression, current depressive symptoms, or certain socioeconomic risk factors (eg, low income or young or single parenthood) would benefit from counseling interventions and could be considered at increased risk. The USPSTF found adequate evidence to bound the potential harms of counseling interventions as no greater than small, based on the nature of the intervention and the low likelihood of serious harms. The USPSTF found inadequate evidence to assess the benefits and harms of other noncounseling interventions. The USPSTF concludes with moderate certainty that providing or referring pregnant or postpartum women at increased risk to counseling interventions has a moderate net benefit in preventing perinatal depression. Conclusions and Recommendation: The USPSTF recommends that clinicians provide or refer pregnant and postpartum persons who are at increased risk of perinatal depression to counseling interventions. (B recommendation).

2 Editorial Exercise as antidepressant treatment: Time for the transition from trials to clinic? 2017

Ekkekakis, Panteleimon / Murri, Martino Belvederi. ·Department of Kinesiology, Iowa State University, Ames, IA 50011, United States. Electronic address: ekkekaki@iastate.edu. · Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, L.go Rosanna Benzi 10, Genoa, Italy. ·Gen Hosp Psychiatry · Pubmed #29173370.

ABSTRACT: -- No abstract --

3 Editorial Exercise as antidepressant treatment: Time for the transition from trials to clinic? 2017

Ekkekakis, Panteleimon / Murri, Martino Belvederi. ·Department of Kinesiology, Iowa State University, Ames, IA 50011, United States. Electronic address: ekkekaki@iastate.edu. · Section of Psychiatry, Department of Neuroscience, Ophthalmology, Genetics and Infant-Maternal Science, University of Genoa, L.go Rosanna Benzi, 10, Genoa, Italy. ·Gen Hosp Psychiatry · Pubmed #29122144.

ABSTRACT: The publisher regrets that this article has been temporarily removed. A replacement will appear as soon as possible in which the reason for the removal of the article will be specified, or the article will be reinstated. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy.

4 Editorial A Medication for Depression With Mixed Features. 2016

Coryell, William. ·From the Department of Psychiatry, University of Iowa, Iowa City. ·Am J Psychiatry · Pubmed #27035528.

ABSTRACT: -- No abstract --

5 Editorial Assessing clinical assessment tools for older adults. 2015

Arndt, Stephan. ·Iowa Consortium for Substance Abuse Research and Evaluation, Department of Psychiatry, Carver College of Medicine, Department of Biostatistics, College of Public Health, University of Iowa, Iowa City, IA. Electronic address: stephan-arndt@uiowa.edu. ·Am J Geriatr Psychiatry · Pubmed #26208888.

ABSTRACT: -- No abstract --

6 Editorial Evolving research in the geriatric neuropsychiatry of stroke. 2013

Robinson, Robert G. ·University of Iowa, Carver College of Medicine, Iowa City, IA. Electronic address: robert-robinson@uiowa.edu. ·Am J Geriatr Psychiatry · Pubmed #23930742.

ABSTRACT: -- No abstract --

7 Review Behavioral and cognitive animal models in headache research. 2019

Vuralli, Doga / Wattiez, Anne-Sophie / Russo, Andrew F / Bolay, Hayrunnisa. ·Department of Neurology and Algology, Gazi University Faculty of Medicine, Besevler, 06510, Ankara, Turkey. · Neuropsychiatry Center, Gazi University, Besevler, 06510, Ankara, Turkey. · Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA, USA. · Center for the Prevention and Treatment of Visual Loss, Iowa VA Health Care System, Iowa City, IA, USA. · Department of Neurology, University of Iowa, Iowa City, IA, USA. · Department of Neurology and Algology, Gazi University Faculty of Medicine, Besevler, 06510, Ankara, Turkey. hbolay@gazi.edu.tr. · Neuropsychiatry Center, Gazi University, Besevler, 06510, Ankara, Turkey. hbolay@gazi.edu.tr. ·J Headache Pain · Pubmed #30704400.

ABSTRACT: Animal models have provided a growing body of information about the pathophysiology of headaches and novel therapeutic targets. In recent years, experiments in awake animals have gained attention as more relevant headache models. Pain can be assessed in animals using behavioral alterations, which includes sensory-discriminative, affective-emotional and cognitive aspects. Spontaneous behavioral alterations such as increased grooming, freezing, eye blinking, wet dog shake and head shake and decreased locomotion, rearing, food or water consumption observed during pain episodes are oftentimes easy to translate into clinical outcomes, but are giving little information about the localization and modality of the pain. Evoked pain response such as tactile and thermal hypersensitivity measures are less translatable but gives more insight into mechanisms of action. Mechanical allodynia is usually assessed with von Frey monofilaments and dynamic aesthesiometer, and thermal allodynia can be evaluated with acetone evaporation test and Hargreaves' test in animal models. Anxiety and depression are the most frequent comorbid diseases in headache disorders. Anxiety-like behaviors are evaluated with the open-field, elevated plus-maze or light/dark box tests. Interpretation of the latter test is challenging in migraine models, as presence of photophobia or photosensitivity can also be measured in light/dark boxes. Depressive behavior is assessed with the forced-swim or tail suspension tests. The majority of headache patients complain of cognitive symptoms and migraine is associated with poor cognitive performance in clinic-based studies. Cluster headache and tension type headache patients also exhibit a reversible cognitive dysfunction during the headache attacks. However, only a limited number of animal studies have investigated cognitive aspects of headache disorders, which remains a relatively unexplored aspect of these pathologies. Thus, the headache field has an excellent and growing selection of model systems that are likely to yield exciting advances in the future.

8 Review Forty years of structural brain imaging in mental disorders: is it clinically useful or not? 2018

Peter, Falkai / Andrea, Schmitt / Nancy, Andreasen. ·Department of Psychiatry and Psychotherapy, University Hospital Munich, Munich, Germany. · Department of Psychiatry, The University of Iowa, Iowa City, USA. ·Dialogues Clin Neurosci · Pubmed #30581287.

ABSTRACT: Structural brain imaging was introduced into routine clinical practice more than 40 years ago with the hope that it would support the diagnosis and treatment of mental disorders. It is now widely used to exclude organic brain disease (eg, brain tumors, cardiovascular, and inflammatory processes) in mental disorders. However, questions have been raised about whether structural brain imaging is still needed today and whether it could also be clinically useful to apply new biostatistical methods, such as machine learning. Therefore, the current paper not only reviews structural findings in Alzheimer disease, depression, bipolar disorder, and schizophrenia but also discusses the role of structural imaging in supporting diagnostic, prognostic, and therapeutic processes in mental disorders. Thus, it attempts to answer the questions whether, after four decades of use, structural brain imaging is clinically useful in mental disorders or whether it will become so in the future.

9 Review Identification and Treatment of Peripartum Anxiety Disorders. 2018

Williams, Katherine E / Koleva, Hristina. ·Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, 401 Quarry Road, Stanford, CA 94305-5717, USA. · Department of Psychiatry, University of Iowa, 200 Hawkins Drive, Iowa City, IA 52242, USA. Electronic address: hristina-koleva@uiowa.edu. ·Obstet Gynecol Clin North Am · Pubmed #30092922.

ABSTRACT: Anxiety disorders in the peripartum period are common and frequently overlooked. They can present de novo or as exacerbations of generalized anxiety disorder, obsessive compulsive disorder, panic disorder and social anxiety disorder, or posttraumatic stress disorder. Calculating a score on the Edinburgh postnatal depression scale is a useful method of screening for these disorders while also screening for perinatal depression. Treatment includes psychotherapy, specifically cognitive behavioral therapy, and antidepressants, the choice of which should be balanced between the severity of symptoms and impact of functioning, risks of untreated illness, and the risks associated with the use of medications in pregnancy and lactation. In summary, anxiety disorders in the peripartum period should be recognized and treated promptly.

10 Review Understanding Mechanisms of Genetic Risk for Adolescent Internalizing and Externalizing Problems: The Mediating Role of Parenting and Personality. 2018

Su, Jinni / Kuo, Sally I-Chun / Bucholz, Kathleen K / Edenberg, Howard J / Kramer, John R / Schuckit, Marc / Dick, Danielle M. ·Department of Psychology,Virginia Commonwealth University,Richmond,Virginia,USA. · Department of Psychiatry,Washington University School of Medicine in St. Louis,St. Louis,Missouri,USA. · Department of Biochemistry and Molecular Biology,Indiana University,Bloomington,Indiana,47405,USA. · Department of Psychiatry,University of Iowa,Iowa City,Iowa,USA. · Department of Psychiatry,University of California at San Diego,La Jolla,California,USA. ·Twin Res Hum Genet · Pubmed #30027866.

ABSTRACT: Genetic predispositions play an important role in the development of internalizing and externalizing behaviors. Understanding the mechanisms through which genetic risk unfolds to influence these developmental outcomes is critical for developing prevention and intervention efforts, capturing key elements of Irv's research agenda and scientific legacy. In this study, we examined the role of parenting and personality in mediating the effect of genetic risk on adolescents' major depressive disorder and conduct disorder symptoms. Longitudinal data were drawn from a sample of 709 European American adolescents and their mothers from the Collaborative Studies on Genetics of Alcoholism. Results from multivariate path analysis indicated that adolescents' depressive symptoms genome-wide polygenic scores (DS_GPS) predicted lower parental knowledge, which in turn was associated with more subsequent major depressive disorder and conduct disorder symptoms. Adolescents' DS_GPS also had indirect effects on these outcomes via personality, with a mediating effect via agreeableness but not via other dimensions of personality. Findings revealed that the pattern of associations was similar across adolescent gender. Our findings emphasize the important role of evocative gene-environment correlation processes and intermediate phenotypes in the pathways of risk from genetic predispositions to complex adolescent outcomes.

11 Review Noninvasive Brain Stimulation: Challenges and Opportunities for a New Clinical Specialty. 2018

Boes, Aaron D / Kelly, Michael S / Trapp, Nicholas T / Stern, Adam P / Press, Daniel Z / Pascual-Leone, Alvaro. ·From the Departments of Pediatrics, Neurology, and Psychiatry, Iowa Neuroimaging and Noninvasive Brain Stimulation Laboratory, University of Iowa Hospitals and Clinics, Iowa City, Iowa (ADB) · the Department of Psychiatry, University of Iowa Hospitals and Clinics, Iowa City, Iowa (NTT) · the Department of Neurology, Division of Cognitive Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Harvard Medical School and Beth Israel Deaconess Medical Center, Boston (ADB, MSK, APS, DZP, AP-L) · and the University of Rochester School of Medicine and Dentistry, Rochester, N.Y. (MSK). ·J Neuropsychiatry Clin Neurosci · Pubmed #29685065.

ABSTRACT: Noninvasive brain stimulation refers to a set of technologies and techniques with which to modulate the excitability of the brain via transcranial stimulation. Two major modalities of noninvasive brain stimulation are transcranial magnetic stimulation (TMS) and transcranial current stimulation. Six TMS devices now have approved uses by the U.S. Food and Drug Administration and are used in clinical practice: five for treating medication refractory depression and the sixth for presurgical mapping of motor and speech areas. Several large, multisite clinical trials are currently underway that aim to expand the number of clinical applications of noninvasive brain stimulation in a way that could affect multiple clinical specialties in the coming years, including psychiatry, neurology, pediatrics, neurosurgery, physical therapy, and physical medicine and rehabilitation. In this article, the authors review some of the anticipated challenges facing the incorporation of noninvasive brain stimulation into clinical practice. Specific topics include establishing efficacy, safety, economics, and education. In discussing these topics, the authors focus on the use of TMS in the treatment of medication refractory depression when possible, because this is the most widely accepted clinical indication for TMS to date. These challenges must be thoughtfully considered to realize the potential of noninvasive brain stimulation as an emerging specialty that aims to enhance the current ability to diagnose and treat disorders of the brain.

12 Review Treatment of Postpartum Depression: Recommendations for the Clinician. 2018

O'Hara, Michael W / Engeldinger, Jane. ·Departments of Psychological and Brain Sciences. · Obstetrics and Gynecology, University of Iowa, Iowa City, Iowa. ·Clin Obstet Gynecol · Pubmed #29351116.

ABSTRACT: Postpartum depression is a significant public health problem affecting almost 600,000 US women every year. It may arise de novo in the postpartum period or continue from pregnancy. A number of evidence-based psychotherapies and medical treatments exist for major depression and postpartum depression. The obstetrical team has many opportunities to identify high risk and depressed women and refer them to mental health professionals or begin treatment with antidepressant medication. Careful assessment of risk factors for postpartum depression during pregnancy and monitoring depressive symptoms during pregnancy and the postpartum period will lead to better outcomes for women and their families.

13 Review A comprehensive review of genetic and epigenetic mechanisms that regulate BDNF expression and function with relevance to major depressive disorder. 2018

Hing, Benjamin / Sathyaputri, Leela / Potash, James B. ·Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa. ·Am J Med Genet B Neuropsychiatr Genet · Pubmed #29243873.

ABSTRACT: Major depressive disorder (MDD) is a mood disorder that affects behavior and impairs cognition. A gene potentially important to this disorder is the brain derived neurotrophic factor (BDNF) as it is involved in processes controlling neuroplasticity. Various mechanisms exist to regulate BDNF's expression level, subcellular localization, and sorting to appropriate secretory pathways. Alterations to these processes by genetic factors and negative stressors can dysregulate its expression, with possible implications for MDD. Here, we review the mechanisms governing the regulation of BDNF expression, and discuss how disease-associated single nucleotide polymorphisms (SNPs) can alter these mechanisms, and influence MDD. As negative stressors increase the likelihood of MDD, we will also discuss the impact of these stressors on BDNF expression, the cellular effect of such a change, and its impact on behavior in animal models of stress. We will also describe epigenetic processes that mediate this change in BDNF expression. Similarities in BDNF expression between animal models of stress and those in MDD will be highlighted. We will also contrast epigenetic patterns at the BDNF locus between animal models of stress, and MDD patients, and address limitations to current clinical studies. Future work should focus on validating current genetic and epigenetic findings in tightly controlled clinical studies. Regions outside of BDNF promoters should also be explored, as should other epigenetic marks, to improve identification of biomarkers for MDD.

14 Review Determinants of behavioral and psychological symptoms of dementia: A scoping review of the evidence. 2017

Kolanowski, Ann / Boltz, Marie / Galik, Elizabeth / Gitlin, Laura N / Kales, Helen C / Resnick, Barbara / Van Haitsma, Kimberly S / Knehans, Amy / Sutterlin, Jane E / Sefcik, Justine S / Liu, Wen / Petrovsky, Darina V / Massimo, Lauren / Gilmore-Bykovskyi, Andrea / MacAndrew, Margaret / Brewster, Glenna / Nalls, Vycki / Jao, Ying-Ling / Duffort, Naomi / Scerpella, Danny. ·College of Nursing, Penn State, University Park, PA. Electronic address: amk20@psu.edu. · College of Nursing, Penn State, University Park, PA. · School of Nursing, University of Maryland, Baltimore, MD. · Department of Community-Public Health, Center for Innovative Care in Aging, Johns Hopkins School of Nursing, Baltimore, MD; Department of Psychiatry, Johns Hopkins School of Medicine, Baltimore, MD. · The Program for Positive Aging, University of Michigan, Ann Arbor, MI; VA Center for Clinical Management Research, Ann Arbor, MI. · Program for Person Centered Living Systems of Care, College of Nursing, The Pennsylvania State University, University Park, PA; Polisher Research Institute, Madlyn & Leonard Abramson Center for Jewish Life, North Wales, PA. · Penn State College of Medicine, Harrell Health Sciences Library, Research & Learning Commons, Hershey, PA. · Penn State, University Park, PA. · School of Nursing, University of Pennsylvania, Philadelphia, PA. · College of Nursing, The University of Iowa, Iowa City, IA. · School of Nursing, University of Wisconsin-Madison, Madison, WI. · Queensland University of Technology, Kelvin Grove, Queensland, Australia. · Center for Sleep and Circadian Neurobiology, Perelman School of Medicine, School of Nursing, University of Pennsylvania, Philadelphia, PA. · Optum Health, Rockville, MD. · Johns Hopkins School of Nursing, Baltimore, MD. · Center for Innovative Care in Aging, Johns Hopkins School of Nursing, Johns Hopkins University, Baltimore, MD. ·Nurs Outlook · Pubmed #28826872.

ABSTRACT: BACKGROUND: Behavioral and psychological symptoms of dementia (BPSD) are prevalent in people with neurodegenerative diseases. PURPOSE: In this scoping review the Kales, Gitlin and Lykestos framework is used to answer the question: What high quality evidence exists for the patient, caregiver and environmental determinants of five specific BPSD: aggression, agitation, apathy, depression and psychosis? METHOD: An a priori review protocol was developed; 692 of 6013 articles retrieved in the search were deemed eligible for review. Gough's Weight of Evidence Framework and the Cochrane Collaboration's tool for assessing risk of bias were used. The findings from 56 high quality/low bias articles are summarized. DISCUSSION: Each symptom had its own set of determinants, but many were common across several symptoms: neurodegeneration, type of dementia, severity of cognitive impairments, and declining functional abilities, and to a lesser extent, caregiver burden and communication. CONCLUSION: Research and policy implications are relevant to the National Plan to Address Alzheimer's Disease.

15 Review Depression as a Risk Factor of Organic Diseases:An International Integrative Review. 2017

Bica, Teodora / Castelló, Ruth / Toussaint, Loren L / Montesó-Curto, Pilar. ·Staff Nurse, Comarcal Mora d'Ebre Hospital, Mora d'Ebre, Spain. · Staff Nurse, Emergency Department., Brighton and Sussex University Hospitals, NHS Trust, Brighton, England. · Professor, Department of Psychology, Luther College, Decorah, IA, USA. · Professor, Department of Nursing, Rovira I Virgili University, Tortosa, Spain. ·J Nurs Scholarsh · Pubmed #28692781.

ABSTRACT: PURPOSE AND DESIGN: This integrative review offers a systematic synthesis of the international literature regarding the role of depression as a risk factor in physical illnesses and the mechanisms of this connection. Special attention is paid to those modifiable factors. FINDINGS: Published studies of depression and physical illness and disease(N = 24) from five countries that were indexed in PubMed, the Cumulative Index to Nursing and Allied Health Literature (CINAHL), APA PsycNET, Scopus, Dialnet, and CUIDEN were examined. Results suggest that depression is a significant risk factor for the development of physical illnesses and diseases. More commonly studied were the connections between depression and cardiovascular disease, metabolic syndrome, biochemical alterations, diabetes, dementia, cognitive impairment, Alzheimer's disease, somatization and chronic pain, asthma, arthritis, and hyperlipidemia. Less frequently studied conditions connected to depression were cancer, infections, allergies, autoimmune disease, gastric ulcer, rhinitis, thyroiditis, bronchitis, migraines, fractures, and osteoporosis. CONCLUSIONS: Mechanisms connecting depression to physical illness appear to involve alterations in the hypothalamic-pituitary axis, unhealthy lifestyle, chronic or acute stressors including posttraumatic stress, an increase in C-reactive protein (CRP) in men, taking antidepressant medication, and social and emotional loneliness. CLINICAL RELEVANCE: A good patient-provider relationship can help to promote decreased acute or chronic stressors, increased family and social support, decreased loneliness, modification of unhealthy lifestyles such as smoking, obesity, physical inactivity, alcohol, control of CRP, and antidepressant medication. Nurses are well placed to help prevent physical diseases through detection and referral of patients who are depressed or undiagnosed and not receiving adequate mental health treatment.

16 Review What are the complications and emerging strategies for preventing depression following traumatic brain injury? 2017

Jones, Melissa / Acion, Laura / Jorge, Ricardo E. ·a VA South Central Mental Illness Research , Education and Clinical Center , Houston , TX , USA. · b Mental Health Care Line , Michael E. DeBakey Veterans Affairs Medical Center , Houston , TX , USA. · c Menninger Department of Psychiatry and Behavioral Sciences , Baylor College of Medicine , Houston , TX , USA. · d Beth K. and Stuart C. Yudofsky Menninger Department of Psychiatry and Behavioral Sciences , Baylor College of Medicine , Houston , TX , USA. · e Iowa Consortium for Substance Abuse Research and Evaluation , University of Iowa , Iowa , IA , USA. ·Expert Rev Neurother · Pubmed #28343407.

ABSTRACT: INTRODUCTION: Depression is a common and disabling complication of traumatic brain injury (TBI). The high rates of post-TBI depression (PTBID) make this condition an important candidate for selective preventive interventions. Areas covered: The authors recently reported on the efficacy of sertraline, a selective serotonin reuptake inhibitor (SSRI), for the prevention of new cases of depression in the first six months after TBI. The authors review this and other studies on preventive strategies in PTBID as ascertained from a PubMed and citation search. The potential complications and barriers to the implementation of pharmacological prevention in patients with TBI are also discussed. Expert commentary: The prevention of depression in patients with TBI has received little attention relative to other medical conditions. Future studies are needed to confirm the benefit of SSRIs and investigate other pharmacological and non-pharmacological interventions, including in special groups of patients at greater risk of developing PTBID.

17 Review Post-traumatic stress disorder in the perinatal period: A concept analysis. 2017

Vignato, Julie / Georges, Jane M / Bush, Ruth A / Connelly, Cynthia D. ·College of Nursing, University of Iowa, Iowa City, IA, USA. · Hahn School of Nursing and Health Science, Beyster Institute for Nursing Research, University of San Diego, San Diego, CA, USA. ·J Clin Nurs · Pubmed #28295746.

ABSTRACT: AIMS AND OBJECTIVES: To report an analysis of the concept of perinatal post-traumatic stress disorder. BACKGROUND: Prevalence of perinatal post-traumatic stress disorder is rising in the USA, with 9% of the U.S. perinatal population diagnosed with the disorder and an additional 18% being at risk for the condition. Left untreated, adverse maternal-child outcomes result in increased morbidity, mortality and healthcare costs. DESIGN: Concept analysis via Walker and Avant's approach. METHODS: The databases Cumulative Index to Nursing and Allied Health Literature (CINAHL), Medline, Academic Search Premier and PsychINFO were searched for articles, written in English, published between 2006-2015, containing the terms perinatal and post-traumatic stress disorder. RESULTS: Perinatal post-traumatic stress disorder owns unique attributes, antecedents and outcomes when compared to post-traumatic stress disorder in other contexts, and may be defined as a disorder arising after a traumatic experience, diagnosed any time from conception to 6 months postpartum, lasting longer than 1 month, leading to specific negative maternal symptoms and poor maternal-infant outcomes. Attributes include a diagnostic time frame (conception to 6 months postpartum), harmful prior or current trauma and specific diagnostic symptomatology defined in the Diagnostic and Statistical Manual of Mental Disorders, 5th edition. Antecedents were identified as trauma (perinatal complications and abuse), postpartum depression and previous psychiatric history. Consequences comprised adverse maternal-infant outcomes. CONCLUSIONS: Further research on perinatal post-traumatic stress disorder antecedents, attributes and outcomes in ethnically diverse populations may provide clinicians a more comprehensive framework for identifying and treating perinatal post-traumatic stress disorder. RELEVANCE TO CLINICAL PRACTICE: Nurses are encouraged to increase their awareness of perinatal post-traumatic stress disorder for early assessment and intervention, and prevention of adverse maternal-infant outcomes.

18 Review A critical review of exercise as a treatment for clinically depressed adults: time to get pragmatic. 2017

Schuch, Felipe Barreto / Morres, Ioannis Dimitrios / Ekkekakis, Panteleimon / Rosenbaum, Simon / Stubbs, Brendon. ·1Post-Graduation Program of Medical Sciences: Psychiatry,Federal University of Rio Grande do Sul,Porto Alegre,Brazil. · 2Exercise Psychology and Quality of Life Laboratory,Department of Physical Education and Sport Science,University of Thessaly,Trikala,Greece. · 3Department of Kinesiology,Iowa States University,Ames,IA,USA. · 4School of Psychiatry,University of New South Wales,Sydney,Australia. · 6Physiotherapy Department,South London and Maudsley NHS Foundation Trust,Denmark Hill,London,UK. ·Acta Neuropsychiatr · Pubmed #27145824.

ABSTRACT: OBJECTIVE: Although considerable evidence supports the efficacy of exercise as an antidepressant treatment, critical reviews informing routine practice and future research directions are scarce. METHODS: We critically reviewed exercise studies for clinically depressed adults, focussing on the PICOS criteria referred to participants, interventions, comparisons, outcomes, and study designs. RESULTS: Most studies have not screened their samples for symptom heterogeneity. Also, they have employed heterogeneous exercise interventions and control groups that may lead to an underestimation of the benefits of exercise. In addition, pragmatic trials allowing scalable replication and implementation in routine practice are scarce. Future studies, can consider the research domain criteria as a diagnostic framework, and conduct moderator analyses to identify depressed subgroups with symptomatology and biopsychosocial characteristics associated with differential responses to exercise interventions. The search for biomarkers of the antidepressant responses to exercise should be prioritised. Further, non-physically active comparison groups should be used to minimise treatment cross-overs and thus the underestimation of the effects of exercise interventions. Finally, the use of outcome measures that maintain their validity at low and moderate levels of symptom severity and the development of trials with a pragmatic design are essential. CONCLUSION: The current evidence base is fraught with methodological considerations that need to be taken into account in order to increase further our understanding on the impact of exercise as medicine in depression. Future research should include moderator analyses, incorporate biomarker assays, use appropriate control and comparison groups, assess outcomes with psychometrically sensitive measures, and prioritise pragmatic trials towards transition to routine practice.

19 Review Depression and serum low-density lipoprotein: A systematic review and meta-analysis. 2016

Persons, Jane E / Fiedorowicz, Jess G. ·Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, United States; Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States. Electronic address: jane-persons@uiowa.edu. · Department of Epidemiology, College of Public Health, University of Iowa, Iowa City, IA, United States; Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, IA, United States; Department of Internal Medicine, Carver College of Medicine, University of Iowa, Iowa City, IA, United States; François M. Abboud Cardiovascular Research Center, Carver College of Medicine, University of Iowa, Iowa City, IA, United States. ·J Affect Disord · Pubmed #27466743.

ABSTRACT: BACKGROUND: A cross-sectional association between depression and serum low-density lipoprotein (LDL) has been noted in the literature. This study aims to employ meta-analytic techniques to clarify the relationship between depression and serum LDL. METHODS: Published articles through April 2015 were identified through systematic query of PubMed with follow-up manual searches. Data from 36 studies reporting mean difference and 7 studies reporting odds ratios were analyzed separately. RESULTS: Meta-analysis of studies modeling serum LDL as a continuous measure demonstrates overall significantly lower serum LDL in depression (Mean difference=-4.29, 95% CI=-8.19, -0.40, p=0.03). Meta-analysis of studies modeling serum LDL as a categorical measure demonstrates a marginally significant lower odds of depression in the presence of low serum LDL relative to high serum LDL (OR=0.90, 95% CI=0.80, 1.01, p=0.08). LIMITATIONS: High heterogeneity was noted across sampled studies, which may be a function of variations in study design, participants sampled, or other factors. The potential for publication bias was also assessed. CONCLUSIONS: This meta-analysis demonstrates a cross-sectional link between depression and low serum LDL.

20 Review Depression and postoperative complications: an overview. 2016

Ghoneim, Mohamed M / O'Hara, Michael W. ·Department of Anesthesia - 6JCP, University of Iowa Hospitals and Clinics, Iowa City, IA, 52242, USA. mohamed-ghoneim@uiowa.edu. · Department of Psychological and Brain Sciences, University of Iowa, Iowa City, IA, 52242, USA. ·BMC Surg · Pubmed #26830195.

ABSTRACT: BACKGROUND: The interaction of depression and anesthesia and surgery may result in significant increases in morbidity and mortality of patients. Major depressive disorder is a frequent complication of surgery, which may lead to further morbidity and mortality. LITERATURE SEARCH: Several electronic data bases, including PubMed, were searched pairing "depression" with surgery, postoperative complications, postoperative cognitive impairment, cognition disorder, intensive care unit, mild cognitive impairment and Alzheimer's disease. REVIEW OF THE LITERATURE: The suppression of the immune system in depressive disorders may expose the patients to increased rates of postoperative infections and increased mortality from cancer. Depression is commonly associated with cognitive impairment, which may be exacerbated postoperatively. There is evidence that acute postoperative pain causes depression and depression lowers the threshold for pain. Depression is also a strong predictor and correlate of chronic post-surgical pain. Many studies have identified depression as an independent risk factor for development of postoperative delirium, which may be a cause for a long and incomplete recovery after surgery. Depression is also frequent in intensive care unit patients and is associated with a lower health-related quality of life and increased mortality. Depression and anxiety have been widely reported soon after coronary artery bypass surgery and remain evident one year after surgery. They may increase the likelihood for new coronary artery events, further hospitalizations and increased mortality. Morbidly obese patients who undergo bariatric surgery have an increased risk of depression. Postoperative depression may also be associated with less weight loss at one year and longer. The extent of preoperative depression in patients scheduled for lumbar discectomy is a predictor of functional outcome and patient's dissatisfaction, especially after revision surgery. General postoperative mortality is increased. CONCLUSIONS: Depression is a frequent cause of morbidity in surgery patients suffering from a wide range of conditions. Depression may be identified through the use of Patient Health Questionnaire-9 or similar instruments. Counseling interventions may be useful in ameliorating depression, but should be subject to clinical trials.

21 Review Post-Stroke Depression: A Review. 2016

Robinson, Robert G / Jorge, Ricardo E. ·From the Department of Psychiatry, Carver College of Medicine, University of Iowa, Iowa City, Iowa; the Michael E. DeBakey VA Medical Center, Houston; and the Department of Psychiatry and Behavioral Sciences, Baylor College of Medicine, Houston. ·Am J Psychiatry · Pubmed #26684921.

ABSTRACT: Poststroke depression (PSD) has been recognized by psychiatrists for more than 100 years, but controlled systematic studies did not begin until the 1970s. Meta-analyses addressing almost all major clinical issues in the field have emerged because of the relatively small number of patients included in some stroke studies. In order to build large databases, these meta-analyses have merged patients with rigorously assessed mood disorders with major depressive features with patients scoring above arbitrary cutoff points on depression rating scales, thus missing important findings such as cognitive impairment associated with major but not minor depression. Nevertheless, PSD occurs in a significant number of patients and constitutes an important complication of stroke, leading to greater disability as well as increased mortality. The most clinically important advances, however, have been in the treatment and prevention of PSD. Recent meta-analyses of randomized controlled trials for the treatment of PSD have demonstrated the efficacy of antidepressants. Similarly, randomized controlled trials for prevention of PSD have shown that antidepressants significantly decrease the incidence of PSD compared with placebo. Early antidepressant treatment of PSD appears to enhance both physical and cognitive recovery from stroke and might increase survival up to 10 years following stroke. There has also been progress in understanding the pathophysiology of PSD. Inflammatory processes might be associated with the onset of at least some depressive symptoms. In addition, genetic and epigenetic variations, white matter disease, cerebrovascular deregulation, altered neuroplasticity, and changes in glutamate neurotransmission might be relevant etiological factors. Further elucidation of the mechanism of PSD may ultimately lead to specific targeted treatments.

22 Review Ketamine and Other NMDA Antagonists: Early Clinical Trials and Possible Mechanisms in Depression. 2015

Newport, D Jeffrey / Carpenter, Linda L / McDonald, William M / Potash, James B / Tohen, Mauricio / Nemeroff, Charles B / Anonymous2720844. ·From the University of Miami Miller School of Medicine, Department of Psychiatry and Behavioral Sciences, Miami; the University of Miami Miller School of Medicine, Department of Obstetrics and Gynecology, Miami; the University of Miami Miller School of Medicine, Center on Aging, Miami; the Alpert Medical School of Brown University, Department of Psychiatry and Human Behavior, Providence, R.I.; Emory University School of Medicine, Department of Psychiatry and Behavioral Sciences, Atlanta; the University of Iowa Carver College of Medicine, Department of Psychiatry, Iowa City, Iowa; and the University of New Mexico Health Science Center, Department of Psychiatry and Behavioral Sciences, Albuquerque, N.M. ·Am J Psychiatry · Pubmed #26423481.

ABSTRACT: OBJECTIVE: The authors conducted a systematic review and meta-analysis of ketamine and other N-methyl-d-aspartate (NMDA) receptor antagonists in the treatment of major depression. METHOD: Searches of MEDLINE, PsycINFO, and other databases were conducted for placebo-controlled, double-blind, randomized clinical trials of NMDA antagonists in the treatment of depression. Primary outcomes were rates of treatment response and transient remission of symptoms. Secondary outcomes included change in depression symptom severity and the frequency and severity of dissociative and psychotomimetic effects. Results for each NMDA antagonist were combined in meta-analyses, reporting odds ratios for dichotomous outcomes and standardized mean differences for continuous outcomes. RESULTS: Ketamine (seven trials encompassing 147 ketamine-treated participants) produced a rapid, yet transient, antidepressant effect, with odds ratios for response and transient remission of symptoms at 24 hours equaling 9.87 (4.37-22.29) and 14.47 (2.67-78.49), respectively, accompanied by brief psychotomimetic and dissociative effects. Ketamine augmentation of ECT (five trials encompassing 89 ketamine-treated participants) significantly reduced depressive symptoms following an initial treatment (Hedges' g=0.933) but not at the conclusion of the ECT course. Other NMDA antagonists failed to consistently demonstrate efficacy; however, two partial agonists at the NMDA coagonist site, d-cycloserine and rapastinel, significantly reduced depressive symptoms without psychotomimetic or dissociative effects. CONCLUSIONS: The antidepressant efficacy of ketamine, and perhaps D-cycloserine and rapastinel, holds promise for future glutamate-modulating strategies; however, the ineffectiveness of other NMDA antagonists suggests that any forthcoming advances will depend on improving our understanding of ketamine's mechanism of action. The fleeting nature of ketamine's therapeutic benefit, coupled with its potential for abuse and neurotoxicity, suggest that its use in the clinical setting warrants caution.

23 Review Pre-treatment effects of peripheral tumors on brain and behavior: neuroinflammatory mechanisms in humans and rodents. 2015

Schrepf, Andrew / Lutgendorf, Susan K / Pyter, Leah M. ·Department of Psychology, University of Iowa, Iowa City, IA 52242, USA. · Department of Psychology, University of Iowa, Iowa City, IA 52242, USA; Departments of Urology and Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, USA. · Institute for Behavioral Medicine Research, Departments of Psychiatry and Behavioral Health and Neuroscience, Ohio State University, Columbus, OH 43210, USA. Electronic address: leah.pyter@osumc.edu. ·Brain Behav Immun · Pubmed #25958011.

ABSTRACT: Cancer patients suffer high levels of affective and cognitive disturbances, which have been attributed to diagnosis-related distress, impairment of quality of life, and side effects of primary treatment. An inflammatory microenvironment is also a feature of the vast majority of solid tumors. However, the ability of tumor-associated biological processes to affect the central nervous system (CNS) has only recently been explored in the context of symptoms of depression and cognitive disturbances. In this review, we summarize the burgeoning evidence from rodent cancer models that solid tumors alter neurobiological pathways and subsequent behavioral processes with relevance to affective and cognitive disturbances reported in human cancer populations. We consider, in parallel, the evidence from human clinical cancer research demonstrating that affective and cognitive disturbances are common in some malignancies prior to diagnosis and treatment. We further consider the underlying neurobiological pathways, including altered neuroinflammation, tryptophan metabolism, prostaglandin synthesis and associated neuroanatomical changes, that are most strongly implicated in the rodent literature and supported by analogous evidence from human cancer populations. We focus on the implications of these findings for behavioral researchers and clinicians, with particular emphasis on methodological issues and areas of future research.

24 Review How robust is the association between smoking and depression in adults? A meta-analysis using linear mixed-effects models. 2014

Luger, Tana M / Suls, Jerry / Vander Weg, Mark W. ·Center for Healthcare Organization and Implementation Research, 200 Springs Road, Building 70 (152), Bedford, MA 02117, USA. Electronic address: Tana.Luger2@va.gov. · Behavioral Research Program, National Cancer Institute, 9609 Medical Center Drive, Bethesda, MD 20892, USA. Electronic address: jerry.suls@nih.gov. · Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA; Comprehensive Access & Delivery Research and Evaluation Center, 601 Highway 6 West, Iowa City, IA 52246, USA; Department of Internal Medicine, University of Iowa, Carver College of Medicine, Iowa City, IA 52242, USA. Electronic address: mark-vanderweg@uiowa.edu. ·Addict Behav · Pubmed #24935795.

ABSTRACT: INTRODUCTION: Our objective was to use meta-analytic techniques to assess the strength of the overall relationship and role of potential moderators in the association between smoking and depression in adults. METHODS: Two popular health and social science databases (PubMed and PsycINFO) were systematically searched to identify studies which examined the association between adult smoking behavior and major depressive disorder (MDD) or depressive symptoms. A total of 85 relevant studies were selected for inclusion. Studies were analyzed using a linear mixed effects modeling package ("lme4" for R) and the Comprehensive Meta-Analysis program version 2. RESULTS: Multiple nested linear mixed-effects models were compared. The best fitting models were those that included only random study effects and smoking status. In cross-sectional studies, current smokers were more likely to be depressed than never smokers (OR=1.50, CI=1.39-1.60), and current smokers were more likely to be depressed than former smokers (OR=1.76, CI=1.48-2.09). The few available prospective studies, that used the requisite statistical adjustments, also showed smokers at baseline had greater odds of incident depression at follow-up than never smokers (OR=1.62, CI=1.10-2.40). CONCLUSIONS: In cross-sectional studies, smoking was associated with a nearly two-fold increased risk of depression relative to both never smokers and former smokers. In the smaller set of prospective studies, the odds of subsequent depression were also higher for current than never smokers. Attesting to its robustness, the relationship between smoking and depression was exhibited across several moderators. Findings could help health care providers to more effectively anticipate co-occurring health issues of their patients. Several methodological recommendations for future research are offered.

25 Review The search for peripheral biomarkers for major depression: benefiting from successes in the biology of smoking. 2014

Philibert, Robert / Gunter, Helen M / Kolassa, Iris-Tatjana. ·Department of Psychiatry, University of Iowa, Iowa City, Iowa; Zukunftskolleg, University of Konstanz, Konstanz, Germany. ·Am J Med Genet B Neuropsychiatr Genet · Pubmed #24591099.

ABSTRACT: The search for robust, clinically useful markers for major depression (MD) has been relatively unproductive. This is unfortunate because MD is one of the largest socio-economic challenges for much of the world and the development of reliable biomarkers for MD could aid in the prevention or treatment of this common syndrome. In this editorial, we compare the approaches taken in the search for biomarkers for MD to that of the more successful searches for biomarkers for tobacco use, and identify several substantive barriers. We suggest that many of the existing clinical repositories used in these biomarkers searches for MD may be of limited value. We conclude that in the future greater attention should be given to the clinical definitions, characterization of confounding environmental factors and age of subjects included in studies. © 2014 Wiley Periodicals, Inc.