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Diabetes Mellitus: HELP
Articles by L. Rydén
Based on 2 articles published since 2010
(Why 2 articles?)
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Between 2010 and 2020, L. Rydén wrote the following 2 articles about Diabetes Mellitus.
 
+ Citations + Abstracts
1 Article Clinical implications of cardiovascular outcome trials in type 2 diabetes. 2019

Mellbin, L G / Wang, A / Rydén, L. ·Cardiology Unit, Department of Medicine K2, Karolinska Institutet, Stockholm, Sweden. linda.mellbin@ki.se. · Heart and Vascular Theme, Karolinska University Hospital, 17176, Stockholm, Sweden. linda.mellbin@ki.se. · Cardiology Unit, Department of Medicine K2, Karolinska Institutet, Stockholm, Sweden. ·Herz · Pubmed #30805659.

ABSTRACT: Cardiovascular disease (CVD) is the main reason for premature death in patients with type 2 diabetes. Hyperglycemia, the hallmark of diabetes, has long been considered the link between diabetes and CVD, and many trials focused on preventing CVD manifestations by means of tight glucose control. However, diabetes is a multifactorial disease in which, e. g., insulin resistance, endothelial dysfunction, and factors such as hypertension and dyslipidemia contribute. Thus, treatment needs to be multifactorial and take cardiovascular aspects into account. Newer classes of drugs, originally launched for glucose lowering, among them dipeptidyl-peptidase (DPP)-4 inhibitors, sodium-glucose cotransporter (SGLT)-2 inhibitors, and glucagon-like peptide (GLP)-1 receptor agonists, have been studied in large cardiovascular outcome trials (CVOT). Several SGLT-2 inhibitors and GLP-1 receptor agonists are associated with a reduction of cardiovascular events (cardiovascular death, nonfatal myocardial infarction, and nonfatal stroke). Although the mechanisms behind the effects are not fully understood, an important reason for the benefits of SGLT-2 inhibitors seems be a reduction in heart failure, while GLP-1 receptor agonists may retard the development of the atherosclerotic vascular disease or may be effective by stabilizing plaques. The outcomes of these studies have been taken into account in recently issued guidelines and an important task for diabetologists, cardiologists, and general practitioners is to incorporate the findings of these trials into clinical practice.

2 Article Severe Periodontitis Is Associated with Myocardial Infarction in Females. 2018

Nordendahl, E / Gustafsson, A / Norhammar, A / Näsman, P / Rydén, L / Kjellström, B / Anonymous10630941. ·1 Department of Dental Medicine, Karolinska Institutet, Stockholm, Sweden. · 2 Department of Medicine, Karolinska Institutet, Stockholm, Sweden. · 3 Capio S:t Görans Hospital, Stockholm, Sweden. · 4 Center for Safety Research, KTH Royal Institute of Technology, Stockholm, Sweden. ·J Dent Res · Pubmed #29596754.

ABSTRACT: The aim of the present study was to test the hypothesis that there is a sex difference in the association between periodontitis (PD) and a first myocardial infarction (MI). The analysis in the case-control study was based on 785 patients (147 females and 638 males) with a first MI and 792 matched controls (147 females and 645 males), screened for cardiovascular risk factors and subjected to a panoramic dental X-ray. Periodontal status was defined by alveolar bone loss and diagnosed as no PD (≥80% remaining alveolar bone), mild to moderate PD (66% to 79%), or severe PD (<66%). Logistic regression was used when analyzing PD as a risk factor for MI, adjusting for age, smoking, diabetes, education, and marital status. The mean age was 64 ± 7 y for females and 62 ± 8 y for males. Severe PD was more common in female patients than female controls (14 vs. 4%, P = 0.005), with an increased risk for severe PD among female patients with a first MI (odds ratio [OR] = 3.92, 95% confidence interval [CI] =1.53 to 10.00, P = 0.005), which remained (OR = 3.72, 95% CI = 1.24 to 11.16, P = 0.005) after adjustments. Male patients had more severe PD (7% vs. 4%; P = 0.005) than male controls and an increased risk for severe PD (OR = 1.88, 95% CI = 1.14 to 3.11, P = 0.005), but this association did not remain following adjustment (OR = 1.67, 95% CI = 0.97 to 2.84, NS). Severe PD was associated with MI in both females and males. After adjustments for relevant confounders, this association did, however, remain only in females. These data underline the importance of considering poor dental health when evaluating cardiovascular risk, especially in females.