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Fibromyalgia: HELP
Articles from Miscellaneous cities in Turkey
Based on 77 articles published since 2008
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These are the 77 published articles about Fibromyalgia that originated from Miscellaneous cities in Turkey during 2008-2019.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4
1 Clinical Trial Cutaneous silent period in fibromyalgia. 2011

Sahin, Ozlem / Yildiz, Serpil / Yildiz, Nebil. ·Department of Physical Medicine and Rehabilitation, Medical Faculty, Cumhuriyet University, Sivas, Turkey. sahinftr@yahoo.com ·Neurol Res · Pubmed #21535931.

ABSTRACT: OBJECTIVES: The pathogenesis of widespread pain and increased tenderness in Fibromyalgia (FM) are still unknown. Recently, the role of central nervous system hyperexcitability is emphasized in pathogenesis of FM. The central sensitization was demonstrated with decrease in nociceptive flexion reflex (NFR) threshold in patients with FM. The NFR and cutaneous silent period (CuSP) are excitatory and inhibitory parts of the same spinal protective reflex, respectively. The aim of this study was to evaluate the changes in CuSP in FM. PATIENTS AND METHODS: Twenty-eight patients with FM and 18 healthy volunteers were subjected to the study. CuSPs on right abductor pollicis brevis muscle evoked by electrical stimulation of the right fifth digit were recorded. RESULTS: The CuSP onset latencies were significantly longer in patients with FM. There was not any significant difference in CuSP duration between patients and controls. CONCLUSION: The latency elongation of the CuSP shows that there is some delay in the development of the inhibitory part of the spinal protective reflex in patients with FM. The observed changes in CuSP of the patients with FM may suggest some abnormalities in the circuits of sensorimotor integration at spinal and supraspinal levels. The results regarding the changes observed in the CuSP in patients with FM should be confirmed by further studies.

2 Article Evaluation of rational drug use knowledge level in patients with musculoskeletal disorders. 2019

Arikan, İnci / Özyigit, Filiz. ·Department of Public Health, Medical Faculty of Kütahya Health Sciences University, Kütahya 43100, Turkey. · Department of Pharmacology, Medical Faculty of Kütahya Health Sciences University, Kütahya 43100, Turkey. ·J Back Musculoskelet Rehabil · Pubmed #30248041.

ABSTRACT: BACKGROUND: For treatment of chronic musculoskeletal disorders pains to be successful, drug interventions are required. OBJECTIVE: In this study, we aimed to evaluate the Rational Drug Use Knowledge Level (RDUKL) in patients with musculoskeletal disorders and some relevant factors. METHOD: The study was carried out in October 2017 on patients treated in the Physical Therapy Rehabilitation Hospital in Turkey. The prepared questionnaire and RDUKL scale were administered to 239 patients by face-to-face interviews. The ANOVA test, chi-squared test and logistic regression model were used for the statistical evaluation. RESULTS: Forty-three percent of the study group was found to have Rational Drug Use Knowledge (RDUK). The patients who used medicines under family supervision had twice as much RDUK as those who did not use medicines under family supervision, and those who were university graduates had six times as much RDUK as those who had primary education or below. Scale score was found to be low in patients with fibromyalgia and high in patients with rheumatoid arthritis (p< 0.05). CONCLUSION: RDUKL was found to be low in the group with chronic diseases and high average age. Besides training, it is important to provide patients with family support about their illness and its treatment. Thus, positive contributions can be made to the increase of the RDUKL.

3 Article A probable case of movement disorder (Tardive dyskinesia) due to duloxetine treatment. 2018

Yılmaz, Resul / Üstün, Damlanur / Tuncer Uzun, Sema / Reisli, Ruhiye / Türk, Şeyda. ·Department of Anesthesiology and Reanimation, Zile State Hospital, Tokat, Turkey. dr.r.yilmaz@gmail.com. ·Agri · Pubmed #30403275.

ABSTRACT: Tardive dyskinesia and tardive dystonia are caused by dopamine receptor blocking agents, mostly antipsychotics and sometimes antidepressants or calcium channel blockers. Duloxetine is a serotonin-noradrenaline reuptake inhibitor used in the treatment of diabetic neuropathic pain and fibromyalgia, as well as major depression. In this case, we aimed to discuss the tardive dyskinesia-like appearance of a patient using duloxetine due to fibromyalgia.

4 Article Frequency of audiological complaints in patients with fibromyalgia syndrome and its relationship with oxidative stress. 2018

Koca, T T / Seyithanoglu, M / Sagiroglu, S / Berk, E / Dagli, H. ·Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Turkey. · Department of Clinic Biochemistry, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Turkey. · Department of Otorhinolaryngology, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Turkey. ·Niger J Clin Pract · Pubmed #30297558.

ABSTRACT: Aim: Central sensitization-related neuroaudiological symptoms are frequently seen in patients with fibromyalgia syndrome (FMS). This study aimed to evaluate the audiological signs and symptoms in patients with FMS and explore their relationship with oxidative stress markers. Methods: This prospective controlled cross-sectional study compared the serum myeloperoxidase, superoxide dismutase, glutathione peroxidase (GPx), nitric oxide (NO), and malondialdehyde (MDA) concentrations in 44 patients with FMS diagnosed according to the 2010 American College of Rheumatology criteria and 44 healthy volunteers. FMS severity was assessed using the visual analog scale and Fibromyalgia Impact Questionnaire. An audiological assessment including vocalizations, vertigo, balance problems, and hearing problems was done to all participants. Results: The two groups were of similar age (P = 0.24), gender (P = 0.40), and weight distribution (P = 0.6). Vertigo, tinnitus, hearing, and balance complaints (P = 0.01/P = 0.00/P = 0.00/P = 0.01) were significantly higher in the FMS group. All subunits and total scores of dizziness handicap inventory were significantly higher (P = 0.00/P = 0.00/P = 0.01/P = 0.01) in the FMS group. An antioxidant GPx and oxidant parameters such as NO and MDA were found to be significantly higher (P = 0.00/P = 0.01/P = 0.02). The hearing assessments at frequencies between 250 and 12,000 Hz showed a significant difference between the two groups (high hearing frequencies in the FMS group) in audiometry. No significant difference was found between the two groups in terms of the presence of stabilo-acoustic reflex, intraaural pressure, and compliance (P = 0.18/P = 0.33/P = 0.41) in tympanogram. Conclusions: Patients with FMS have high levels of oxidative stress markers (GPx, NO, and MDA), highly frequent audiological symptoms with high hearing frequencies in audiometry, independent of disease severity.

5 Article Paresthesia frequency in fibromyalgia and its effects on personality traits. 2018

Balbaloglu, Ozlem / Tanik, Nermin / Alpayci, Mahmut / Ak, Hakan / Karaahmet, Elif / Inan, Levent Ertugrul. ·Department of Physical Medicine and Rehabilitation, Medical Faculty of Bozok University, Yozgat, Turkey. · Department of Neurology, Medical Faculty of Bozok University, Yozgat, Turkey. · Department of Physical Medicine and Rehabilitation, Spesial Hospital, Diyarbakır, Turkey. · Department of Neurosurgery, Medical Faculty of Bozok University, Yozgat, Turkey. · Department of Psychiatry, Okmeydanı Training and Research Hospital, Istanbul, Turkey. ·Int J Rheum Dis · Pubmed #29968325.

ABSTRACT: AIM: Paresthesia and personality disorders are common conditions among patients with fibromyalgia. However, no previous study has examined a possible relation of paresthesia with personality traits in fibromyalgia. This study investigates the frequency of paresthesia in fibromyalgia patients and its relation with personality traits. METHOD: Female patients with fibromyalgia (n = 101) were divided into two groups according to the presence (n = 49; mean age 40.63 ± 7.62 years; range 23-55 years) or absence (n = 52; mean age 40.50 ± 7.12 years; range 27-53 years) of paresthesia. Also, a healthy control group (n = 53; mean age 39.34 ± 5.26 years; range 23-55 years) was included. The groups were evaluated by the Temperament and Character Inventory. Accordingly, temperament includes four dimensions: harm avoidance, novelty seeking, persistence, reward dependence; and character consists of three dimensions: cooperativeness, self-transcendence, self-directedness. RESULTS: There were no significant differences among the three groups in the scores of novelty seeking, persistence, reward dependence and cooperativeness (for all P > 0.05). Both fibromyalgia groups had significantly higher scores in harm avoidance and had lower scores in self-directedness compared to the control group (P < 0.001). Also, fibromyalgia patients with paresthesia had significantly higher harm avoidance and self-directedness scores than those in patients without paresthesia (P < 0.001). In both fibromyalgia groups, self-transcendence scores were similar (P = 0.465) but significantly higher than in the control group (P < 0.001). CONCLUSION: This is the first study evaluating the association of paresthesia and personality traits in fibromyalgia. These results suggest that psychological distress associated with high harm avoidance and low self-directedness scores are more prominent in fibromyalgia patients, and especially of those who have paresthesia.

6 Article Evaluation of allergic rhinitis with nasal symptoms and nasal mucociliary clearance in patients with fibromyalgia syndrome. 2018

Doğan, Sevil Ceyhan / Karadağ, Ahmet / Durmuş, Kasım / Şahin, Özlem / Altuntaş, Emine Elif. ·Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey. · Department of Otolaryngology, Faculty of Medicine, Cumhuriyet University, Sivas, Turkey. ·J Back Musculoskelet Rehabil · Pubmed #29889054.

ABSTRACT: BACKROUND: The exact etiopathogenesis of fibromyalgia syndrome (FM) is still unclear but the pathogenesis of FM is associated with neurogenic inflammation. Allergic rhinitis (AR) is a common inflammatory and immunological disease of the nasal mucosa. As a result, it is known that neurogenic inflammation has a role in the pathophysiology of both FM and AR. OBJECTIVE: The aim of this study was to evaluate AR and nasal allergic inflammation using nasal mucociliary clearance time (NMC) in FM patients. METHODS: Forty-five FM patients and fifty healthy controls were included in the study. In both groups, AR was evaluated by total nasal symptom scoring (TNSS) and NMC was measured using saccharine transit time test (STT). RESULTS: TNSS was positive in 9 patients (20%) in the FM group and no positivity in the control group. In FM group, the mean value of TNSS was higher than that of the control group (p= 0.0001). The average value of STT of FM patients was statistically significantly longer when compared to the control group (p= 0.0001). CONCLUSION: The results we obtained suggest that there is a high possibility of coexistence of FM and AR. As a result, the coexistence of AR and FM cannot be denied but we believe that comprehensive clinical studies should be conducted on this subject.

7 Article The relationship with restless legs syndrome, fibromyalgia, and depressive symptoms in migraine patients. 2018

Akdag Uzun, Zehra / Kurt, Semiha / Karaer Unaldi, Hatice. ·Yenimahalle Training and Research Hospital, Department of Neurology, Yildirim Beyazit University, Ankara, Turkey. · Faculty of Medicine, Department of Neurology, Gaziosmanpasa University, Tokat, Turkey. gsemihakurt@hotmail.com. · Department of Neurology, Minasera Aldan Hospital, Ankara, Turkey. ·Neurol Sci · Pubmed #29777478.

ABSTRACT: OBJECTIVE: In this study, we aimed to investigate restless legs syndrome, depression, frequency of fibromyalgia and possible causes of its frequencies, and the relationships among these synergies and migraine's prodrome, aura, pain, and postdrome symptoms in patients with migraine. SUBJECTS AND METHODS: The study group included 200 patients previously or recently diagnosed with definite migraine and according to International Headache Society criteria and 200 healthy volunteers. All subjects underwent a medical interview to confirm restless legs syndrome and fibromyalgia, and they were asked to complete Beck Depression and Anxiety Inventory and "severity of restless legs syndrome inventory." RESULTS: The frequencies of depressive symptoms and fibromyalgia in the patients with migraine were higher than those of the control group. The mean age of the migraine patients with restless legs syndrome was also higher, and this group had migraine headache for a longer time. There was a statistically significant difference with regard to only generalized anxiety and traveler's distress, which were features of the migraine, between migraine patients with and without restless legs syndrome. Restless legs syndrome was more common in migraine patients with and without aura and in those with nonspecific white matter lesions in the cranial MRI. CONCLUSIONS: In our study, the greater frequency of restless legs syndrome, depressive symptoms, and fibromyalgia in the patients with migraine supports the role of dopamine, which is common to all three disorders. Interviews focused on these problems among migraine patients may help to decide on the best available treatment modality.

8 Article Effects of whole body vibration therapy in pain, function and depression of the patients with fibromyalgia. 2017

Alev, Alp / Mihriban, Adalı / Bilge, Efe / Ayça, Elyıldırım / Merve, Karabulut / Şeyma, Coşkun / Uğur, Ertem / Adnan, Bilgiç / Zeynel, Karakullukçuoğlu / Mahmut, Günay Selim. ·Uludağ University Physical Therapy and Rehabilitation Department, Kükürtlü, 16080, Bursa, Turkey. Electronic address: dr.alevalp@gmail.com. · Uludağ University Physical Therapy and Rehabilitation Department, Kükürtlü, 16080, Bursa, Turkey. ·Complement Ther Clin Pract · Pubmed #28779930.

ABSTRACT: AIM: Aim of the study is to search the effects of whole body vibration (WBV) in fibromyalgia patients. MATERIALS AND METHODS: In this single blind study 20 fibromyalgia patients were diagnosed according to 2010 American College of Rheumatology criteria whom participated in the study with the mean age of 57 ± 7 (years). Participants were randomized into 2 equal groups. In the intervention group (n = 10), 6 different types of exercises were combined with 30 hz frequency, 2 mm amplitude WBV for 4 weeks, The control group (n = 10) performed the same exercises on the same platform without vibration. The patients were assessed at baseline, at the 3rd and 6th months by Visual Analogue Scale (VAS), Fibromyalgia Impact Questionnaire (FIQ) and Beck Depression Inventory (BDI). RESULTS: Only FIQ score was significantly better in the treatment group at the 6th month evaluation (p = 0.043). CONCLUSION: WBV is found to be effective in reducing symptoms of fibromyalgia.

9 Article Decreased olfactory bulb volumes in patients with fibromyalgia syndrome. 2017

Sayılır, Selçuk / Çullu, Neşat. ·Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Muğla Sıtkı Koçman University, Muğla, Turkey. selcukssay@gmail.com. · Faculty of Medicine, Department of Radiology, Muğla Sıtkı Koçman University, Muğla, Turkey. ·Clin Rheumatol · Pubmed #28744789.

ABSTRACT: Among the other symptoms, impaired olfactory function such as odor identification, threshold, and discrimination have been reported in patients with fibromyalgia syndrome (FMS). To investigate olfactory bulb (OB) volumes in FMS, by using magnetic resonance imaging (MRI), and to make reasonable suggestions are the goals of the present study. The study included 62 individuals as the FMS group (n = 30) and the control group (n = 32). MRI examinations were performed by a 1.5-T scanner and a standard head coil was used for the images. The coronal T2-weighted images were used for to measure OB volumes. Right, left, and total OB volumes were calculated with the aid of these images. The mean age of the FMS group was 44.2 ± 8.3 years and the control group was 41.7 ± 3.53 years. The mean volume of the right OB was 74.9 ± 12.4 mm

10 Article Evaluation of blood neutrophil-lymphocyte ratio and platelet distribution width as inflammatory markers in patients with fibromyalgia. 2017

Aktürk, Semra / Büyükavcı, Raikan. ·Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Inönü University, Malatya, Turkey. semrakayakturk@hotmail.com. · Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Inönü University, Malatya, Turkey. ·Clin Rheumatol · Pubmed #28466420.

ABSTRACT: Fibromyalgia syndrome (FMS) is characterized by chronic widespread pain and systemic symptoms. The aetiology and pathogenesis of fibromyalgia are not yet fully understood. Blood neutrophil/lymphocyte ratio (NLR) is a marker of systemic inflammatory response. Platelet distribution width (PDW) and mean platelet volume (MPV) are the determinants of platelet activation and studied as markers in inflammatory diseases. The aim of the present study was to evaluate levels of NLR,PDW and MPV in patients with fibromyalgia. A total of 197 FMS patients and 53 healthy controls are included in the study. Demographic characteristics, erythrocyte sedimentation rate, C-reactive protein, neutrophil, lymphocyte and platelet counts, platelet distribution width and mean platelet volume levels were recorded. In the patient group, the blood NLR and MPV were significantly higher and the PDW was significantly lower compared to the control group. In the roc curve analysis, blood PDW ≥had 90.4% sensitivity and 90% specificity in predicting fibromyalgia. The results of this study suggest NLR and PDW as promising inflammatory markers indicating fibromyalgia and may be beneficial in facilitating the diagnosis of FMS patients.

11 Article The association between pain and sleep in fibromyalgia. 2017

Keskindag, Buse / Karaaziz, Meryem. ·Department of Psychology, Faculty of Arts and Sciences, Near East University, North Cyprus, Turkey. E-mail. busekeskindag@outlook.com. ·Saudi Med J · Pubmed #28439595.

ABSTRACT: OBJECTIVE: To clarify the association between pain and sleep in fibromyalgia.  Methods: Electronic databases, including PsycINFO, the Cochrane database for systematic reviews, PubMed, EMBASE, and Ovid were searched to identify eligible articles. Databases independently screened and  the quality of evidence using a reliable and valid quality assessment tool was assessed.  Results: In total, 16 quantitative studies fulfilled the inclusion criteria. According to the results, increased pain in fibromyalgia was associated with reduced sleep quality, efficiency, and duration and increased sleep disturbance and onset latency and total wake time. Remarkably, depressive symptoms were also related to both pain and sleep in patients with fibromyalgia.   Conclusion: Management strategies should be  developed to decrease pain while increasing sleep quality in patients with fibromyalgia. Future studies should also consider mood disorders and emotional dysfunction, as comorbid conditions could occur with both pain and sleep disorder in fibromyalgia.

12 Article Premenstrual syndrome and fibromyalgia: the frequency of the coexistence and their effects on quality of life. 2017

Soyupek, Feray / Aydogan, Cigdem / Guney, Mehmet / Kose, Seyit Ali. ·a Department of Physical Medicine and Rehabilitation , Suleyman Demirel University , Isparta , Turkey , and. · b Department of Obsteric and Gynecology , Suleyman Demirel University , Isparta , Turkey. ·Gynecol Endocrinol · Pubmed #28277106.

ABSTRACT: OBJECTIVE: We aimed to investigate the association between Premenstrual syndrome (PMS) and fibromyalgia syndrome (FMS), to assess common symptoms and quality of life (QOL) of them. METHODS: Patients with PMS formed the PMS group and age-matched healthy normal controls were included in the control group. The diagnosis of the FMS and PMS were based on new American College of Rheumatology FMS criteria and DSM-IV PMS criteria. FMS-related symptoms assessed by visual analog scale and number of tender points (TePs) were analyzed. QOL, PMS severity and FMS severity were assessed with SF-36, fibromyalgia impact questionnaire (FIQ) and premenstrual assessment form (PAF), respectively. Patients with PMS were divided into two subgroups according to coexistence of FMS or not. RESULTS: The frequency of FMS in PMS and control group were 20 and 0%, respectively (p = 0.002). FMS-related symptoms, number of TePs in the PMS group were higher than those in the control group. The mean mental component summary (MCS) score of SF-36 was low in the PMS group. The mean PAF score in PMS with FMS subgroup was higher than those in without FMS subgroup. The mean physical component summary of SF-36 was low in the PMS patient with FMS. There was correlation between PAF score and FIQ score (r = 0.476, p < 0.001). CONCLUSION: FMS was common among the patients with PMS and frequently seen in the PMS patients having severe premenstrual complaints. Mental QOL was distressed in the patients with PMS but while FMS accompanied to PMS, the physical QOL was decreased.

13 Article The role of oxidative stress in the relation between fibromyalgia and obstructive sleep apnea syndrome. 2017

Yildirim, T / Alp, R. ·Physiotherapy and Rehabilitation, Inonu University School of Medicine, Malatya, Turkey. drtulayoner@hotmail.com. ·Eur Rev Med Pharmacol Sci · Pubmed #28121361.

ABSTRACT: OBJECTIVE: The aim of this study is to examine the involvement of oxidative and antioxidative parameters and to evaluate the relation between fibromyalgia (FMS) and obstructive sleep apnea syndrome (OSAS). PATIENTS AND METHODS: Oxidative stress was determined by measuring the levels of malondialdehyde (MDA) and antioxidative parameters (superoxide dismutase [SOD], catalase [CAT], and glutathione peroxidase [GPx]) in 131 randomly selected patients with OSAS. The control group was composed of 129 subjects with no clinical OSAS symptoms. OSAS was diagnosed by polysomnographic tests. All patients underwent overnight polysomnographic recording. The diagnosis of fibromyalgia was made following the diagnostic criteria of the American College of Rheumatology. The FMS patients used visual analog scales (VAS) to evaluate their pain, and they completed the FMS Impact Questionnaire (FIQ). All subjects completed the 36-item Short Form Health Survey (SF-36) and the Beck Depression Inventory (BDI). RESULTS: In the OSAS + FMS group, CAT, SOD, and GDX were found to be statistically significantly lower and MDA was found to be statistically significantly higher than in both the control group and the OSAS group (p = 0.0001). A significant difference was found about gender between the OSAS group and the OSAS+FMS group (p = 0.0001). In the OSAS + FMS group, BDI was found to be statistically significantly higher than in both the control group and the OSAS group (p = 0.0001). In the OSAS + FMS group, SF 36 was found to be statistically significantly higher than in both the control group and the OSAS group (p = 0.0001). No differences were observed between the groups about AHI, minimum O2 saturation, or total sleep time values. About the presence of FMS presence, no differences were detected among the mild, moderate, and severe OSAS groups (p = 0.831). A negative correlation was determined between AHI and VAS and total sleep and sensitive points (p = 0.0001). A negative correlation was shown between CAT and GPX, SOD and apnea/hypopnea index (AHI) (p = 0.0001). A positive correlation was shown between CAT, GPX and SOD (p = 0.0001). A minimum O2 saturation was detected. A positive correlation between MDA and AHI (p = 0.0001), and a negative correlation between MDA and O2 saturation (p = 0.0001) were found. CONCLUSIONS: OSAS and FMS were highly prevalent, which indicated that oxidative stress might play a role in the pathophysiology of both diseases, especially if they co-exist in the same patient.

14 Article The relationship between balance and vitamin 25(OH)D in fibromyalgia patients. 2017

Kasapoğlu Aksoy, Meliha / Altan, Lale / Ökmen Metin, Burcu. ·a Department of Physical Medicine and Rehabilitation , Sağlık Bilimleri University Bursa Yüksek Ihtisas Training and Research Hospital , Bursa , Turkey and. · b Department of Physical Medicine and Rehabilitation , Uludağ University Medicine Faculty , Bursa , Turkey. ·Mod Rheumatol · Pubmed #27846770.

ABSTRACT: INTRODUCTION: Fibromyalgia syndrome (FMS) is a chronic disease characterized by diffuse pain of unknown cause, fatigue, sleep disorders, cognitive dysfunction, and sensitivity. Fibromyalgia was shown to be associated with balance problems and increased incidence of falls. There are many theoretical mechanisms related to the impact of vitamin D on postural control. The aim of the current study was to investigate the relationship between vitamin 25(OH)D levels and pain, balance and daily activities in patients with FMS. METHOD: Patients aged 35-65 years who were diagnosed with FMS according to 1990 ACR diagnostic criteria were screened. Seventy patients diagnosed with FMS and 60 healthy controls with comparable age and gender were included in the study. Fibromyalgia impact scale (FIQ), Berg Balance Scale (BBS), the Nottingham Health Profile (NHP), and visual analog scale (VAS) were applied to the subjects. The subjects were divided into two groups by vitamin 25(OH)D level being above or below 30 ng/ml. RESULTS: A statistically significant difference was established between VAS, BBS value and all NHP subscale and NHP total values of FMS patients and those of healthy control group. The relationship between BBS and the level of vitamin 25(OH)D of all participants was investigated, a positive statistically significant relationship was found with Vit-D at r = 0.481 level (p < 0.05). CONCLUSION: It was observed that low vitamin D levels affected balance in both FMS group and healthy control group. It should be kept in mind that vitamin D level is likely to negatively affect balance and VAS values in FMS.

15 Article Hemorheological parameters in patients with fibromyalgia syndrome. 2017

Arihan, Okan / Caglayan, Gokhan / Bayrak, Sibel / Akinci, Aysen / Falkmarken, Neslihan Dikmenoglu. ·Department of Physiology, Yuzuncu Yil University Faculty of Medicine, Van, Turkey. · Division of Rheumatology, Department of Physical and Rehabilitation Medicine, Cumhuriyet University Faculty of Medicine, Sivas, Turkey. · Department of Physiology, Hacettepe University Faculty of Medicine, Ankara, Turkey. · Department of Physical and Rehabilitation Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey. ·Clin Hemorheol Microcirc · Pubmed #27814281.

ABSTRACT: AIM: To evaluate hemorheological parameters in patients with fibromyalgia syndrome (FMS) in order to elucidate the etiology of the disease. METHODS: Twenty-three adult FMS patients and 20 healthy controls were enrolled in the study. Diabetics, hypertensives and those with any rheumatological disorder or use drugs or smoking cigarette were excluded from the study. Following parameters were analyzed in each subject; erythrocyte deformability, erythrocyte aggregation, plasma viscosity, complete blood count, fasting blood glucose, fibrinogen, albumin, globulin and lipid profile. RESULTS: Erythrocyte elongation indices indicating deformability of erythrocytes were higher in FMS patients (0.564±0.002 at 16.87 mPa and 0.605±0.002 at 30 mPa shear rate) than controls (0.558±0.001 at 16.87 mPa and 0.600±0.003 at 30 mPa shear rate). Erythrocyte aggregation speed was higher in FMS patients (2.1±0.1 s) than controls (2.3±0.2 s). Erythrocyte aggregation index was also higher in FMS patients (65.5±1.3) than controls (62.9±1.5). Erythrocyte aggregation amplitude and plasma viscosity values were similar in both groups (both p > 0.05). Among the complete blood count and biochemical parameters, only albumin levels were lower in the FM patients than controls (p < 0.05). CONCLUSION: Our results indicate higher erythrocyte deformability and quicker erythrocyte aggregation in FM patients.

16 Article Investigation of Nerve Conduction Studies of Carpal Tunnel Syndrome Cases With Different Risk Factors: An Electrodiagnostic Study. 2017

Solmaz, Volkan / Yavuz, Selçuk / İnanr, Ahmet / Aksoy, Dürdane / Pektaş, Elmas / Tekataş, Aslan / Kurt, Semiha G. ·*Department of Neurology, Faculty of Medicine, Trakya University, Edirne, Turkey; †Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Trakya University, Edirne, Turkey; ‡Department of Physical Therapy and Rehabilitation, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey; and §Department of Neurology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey. ·J Clin Neurophysiol · Pubmed #27753734.

ABSTRACT: PURPOSE: The aim of this study was to determine whether there are electrodiagnostic differences between carpal tunnel syndrome (CTS) patients with diabetes mellitus, CTS + hypothyroidism (HT), CTS + fibromyalgia syndrome, CTS + rheumatoid arthritis (RA), and idiopathic CTS cases, by comparing nerve conduction studies. METHODS: This research examined electrophysiologic studies of 47 untreated HT + CTS, 47 diabetes mellitus + CTS, 49 RA + CTS, 52 fibromyalgia syndrome + CTS, 50 idiopathic CTS cases, and a healthy control group of 50 individuals (a total of 293 patients and 433 hands with CTS). RESULTS: There were no significant differences between the groups in terms of sex and age. There was no significant difference between the CTS groups-in terms of numbers-with mild, moderate, and severe CTS. When the CTS groups were compared with the control group, in all CTS groups on both left and right hands, there was a significant prolongation in median motor latency and median sensory latency (in the 3rd finger); also a significant decrease in median sensory velocity in the 3rd finger. In diabetes mellitus, HT, and RA groups, the median motor amplitudes in both hands were significantly decreased compared with the idiopathic group. There was a moderate significant negative correlation between disease duration and median motor amplitudes (of both right and left sides) in RA (right; P = 0.028, r = 0.761, left; P = 0.041, r = 0.694) and HT groups (right; P = 0.035, r = 0.637, left; P = 0.049, r = 0.697). CONCLUSIONS: Electrodiagnostic results showed both demyelinating injury and axonal damage in diabetes mellitus, HT, and RA patients with CTS, in these patients during treatment for CTS. Early treatment planning should include the risk factor diseases.

17 Article Lower serotonin level and higher rate of fibromyalgia syndrome with advancing pregnancy. 2017

Atasever, Melahat / Namlı Kalem, Muberra / Sönmez, Çiğdem / Seval, Mehmet Murat / Yüce, Tuncay / Sahin Aker, Seda / Koç, Acar / Genc, Hakan. ·a Department of Gynecology and Obstetrics , Giresun University Faculty of Medicine , Giresun , Turkey. · b Department of Gynecology and Obstetrics , Turgut Ozal University Faculty of Medicine , Ankara , Turkey. · c Department of Clinical Biochemistry , Dr Abdurrahman Yurtarslan Oncology Education and Research Hospital , Ankara , Turkey. · d Department of Gynecology and Obstetrics , Ankara University Faculty of Medicine , Ankara , Turkey. · e Department of Obstetrics and Gynecology , Dr. Sami Ulus Children and Woman Health Training and Research Hospital , Ankara , Turkey and. · f Department of Physical Medicine and Rehabilitation , University of Health Sciences, Ankara Traning and Research Hospital , Ankara , Turkey. ·J Matern Fetal Neonatal Med · Pubmed #27696917.

ABSTRACT: OBJECTIVE: The aim of the study is to investigate the relationship between changes in serotonin levels during pregnancy and fibromyalgia syndrome (FS) and the relationships between FS and the physical/psychological state, biochemical and hormonal parameters, which may be related to the musculoskeletal system. STUDY DESIGN: This study is a prospective case-control study conducted with 277 pregnant women at the obstetric unit of Ankara University Faculty of Medicine, in the period between January and June 2015. FS was determined based on the presence or absence of the 2010 ACR diagnostic criteria and all the volunteers were asked to answer the questionnaires as Fibromyalgia Impact Criteria (FIQ), Widespread Pain Index (WPI), Symptom Severity Scale (SS), Beck Depression Inventory and Visual Analog Scale (VAS). Biochemical and hormonal markers (glucose, TSH, T4, Ca (calcium), P (phosphate), PTH (parathyroid hormone) and serotonin levels) relating to muscle and bone metabolism were measured. RESULTS: In the presence of fibromyalgia, the physical and psychological parameters are negatively affected (p < 0.001). There was no significant difference between the fibromyalgia and control groups in terms of glucose, Ca (calcium), P (phosphorus), PTH (parathyroid hormone), TSH (thyroid stimulant hormone), fT4 (free T4) levels (p = 0.060, 0.799, 0.074, 0.104, 0.797, 0.929, respectively). A reduction in serotonin levels may contribute to the development of fibromyalgia but this was not statistically significant. The Beck Depression Inventory scale statistically showed that increasing scores also increase the risk of fibromyalgia (p <0.001). CONCLUSION: Our study has shown that serotonin levels in women with FS are lower than the control group and that serotonin levels reduce as pregnancy progresses. Anxiety and depression in pregnant women with FS are higher than the control group. The presence of depression increases the likelihood of developing FS at a statistically significant level. Serotonin impairment also increases the chance of developing FS, but this correlation has not been shown to be statistically significant.

18 Article Evaluation of pain sensitivity by tender point counts and myalgic score in patients with and without obstructive sleep apnea syndrome. 2017

Terzi, Rabia / Yılmaz, Zahide. ·Department of Physical Medicine and Rehabilitation, Derince Training and Research Hospital, Kocaeli, Turkey. · Department of Neurology, Derince Training and Research Hospital, Kocaeli, Turkey. ·Int J Rheum Dis · Pubmed #26258423.

ABSTRACT: AIM: The purpose of this study was to assess the difference between patients with and without obstructive sleep apnea syndrome (OSAS) with respect to pain sensitivity. METHOD: The study was conducted on 31 womens diagnosed with OSAS and 31 healthy women. All patients underwent polysomnographic testing. A pressure algometer (dolorimeter) was used to measure the pressure pain threshold. Fibromyalgia was diagnosed based on the 1990 American College of Rheumatology diagnosis criteria. RESULTS: The myalgic score was 73.95 ± 18.09 in patients with OSAS, while this value was 84.18 ± 24.31 in the control group. The difference between the groups was statistically significant (P = 0.041).The number of tender points was 8.19 ± 3.35 in the patient group with OSAS, while this number was 6.35 ± 2.23 in the control group. The difference between the two groups was statistically significant (P = 0.014). No statistically significant differences were found between age, body mass index, Beck depression scores, control point score and the presence of fibromyalgia, between the two groups (P > 0.05). A statistically significant positive correlation was found between the myalgic scores and mean saturation O CONCLUSION: The differences noted between OSAS patients and the control group with respect to myalgic score and the number of tender points suggest that there might be a relation between OSAS and pain sensitivity. There might be an association between low oxygen saturation and total myalgic score.

19 Article Efficacy of vitamin D replacement therapy on patients with chronic nonspecific widespread musculoskeletal pain with vitamin D deficiency. 2016

Yilmaz, Ramazan / Salli, Ali / Cingoz, Havva Turac / Kucuksen, Sami / Ugurlu, Hatice. ·Department of Physical Medicine and Rehabilitation, Yoncali Physical Medicine and Rehabilitation Hospital, Kutahya, Turkey. · Department of Physical Medicine and Rehabilitation, Meram Medical School, Necmettin Erbakan University, Konya, Turkey. · Department of Physical Medicine and Rehabilitation, Seydisehir State Hospital, Konya, Turkey. ·Int J Rheum Dis · Pubmed #27860257.

ABSTRACT: AIM: The objective of this study is the evaluation of the effect of vitamin D replacement treatment on musculoskeletal symptoms and quality of life in patients with chronic widespread musculoskeletal pain (CWP) including fibromyalgia (FM) and vitamin D deficiency. METHOD: Patients with nonspecific CWP and vitamin D deficiency (25-OH D3 < 25 ng/mL) were included into the study. Replacement treatments of 50 000 IU/week oral vitamin D3 for 3 months were given to the patients. Patients were assessed pre- and post-treatment in terms of serum levels of Ca, P, alkaline phosphatase, 25-OH D3, severity of pain (visual analogue scale [VAS]-pain), severity of asthenia (VAS-asthenia), Beck Depression Inventory (BDI), quality of life scale (Short Form [SF]-36), tender point count (TPC), severity of waking unrefreshed, headache, tenderness on tibia, meeting the criteria of FM, and level of patient satisfaction. RESULTS: Fifty-eight patients with a mean age of 36.9 ± 9.2 years were included into the study. 25-OH D3 levels of patients elevated from 10.6 ± 5.1 ng/mL to 46.5 ± 24.0 ng/mL after replacement treatment (P < 0.001). Marked decrease in VAS-pain, VAS-asthenia, severity of waking unrefreshed, TPC, and BDI and an evident increase in subgroups of SF-36 were established in patients after treatment (P < 0.001). The number of FM+ patients was 30 (52%) before treatment and regressed to 20 (34%) after treatment (P = 0.013); 85% of patients stated satisfaction with the treatment. CONCLUSIONS: Vitamin D replacement treatment in patients with nonspecific CWP has provided improvements in musculoskeletal symptoms, level of depression and quality of life of patients. Patients with CWP should be investigated for vitamin D deficiency.

20 Article Comparison of education and balneotherapy efficacy in patients with fibromyalgia syndrome: A randomized, controlled clinical study. 2016

Koçyiğit, Burhan Fatih / Gür, Ali / Altındağ, Özlem / Akyol, Ahmet / Gürsoy, Savaş. ·Department of Physical Medicine and Rehabilitation, Gaziantep University Faculty of Medicine, Gaziantep, Turkey. bfk2701@hotmail.com. · Department of Physical Medicine and Rehabilitation, Gaziantep University Faculty of Medicine, Gaziantep, Turkey. ·Agri · Pubmed #27225736.

ABSTRACT: OBJECTIVES: Fibromyalgia is a disease characterized by chronic, widespread pain. Pharmacological and non-pharmacological treatment methods are used. The aim of the present study was to determine the effect of balneotherapy on treatment of fibromyalgia syndrome, compared with education alone. METHODS: A total of 66 patients diagnosed with fibromyalgia syndrome were randomly separated into balneotherapy and control groups. Patients in both groups were informed about fibromyalgia syndrome. In addition, the balneotherapy group received 21 sessions of spa treatment with 34.8 °C thermomineral water, attending the spa 5 days a week. Patients were evaluated by visual analogue scale, tender point count, fibromyalgia impact questioning, and modified fatigue impact scale at initiation of treatment on the 15th day, 1st month, 3rd month, and 6th month. Evaluations were performed by the same doctor. RESULTS: Statistically significant improvement was detected in all parameters, compared to starting evaluation, in both groups. Most improved results among all parameters were observed in the balneotherapy group on the first 3-month follow-up. In addition, all parameters beyond tender point count and modified fatigue impact were improved on 6-month follow-up. CONCLUSION: It was concluded that addition of balneotherapy to patient education has both short- and long-term beneficial effects on female patients with fibromyalgia.

21 Article Rule based fuzzy logic approach for classification of fibromyalgia syndrome. 2016

Arslan, Evren / Yildiz, Sedat / Albayrak, Yalcin / Koklukaya, Etem. ·Department of Electrical and Electronics Engineering, Faculty of Engineering, Sakarya University, Sakarya, Turkey. · Department of Physical Medicine and Rehabilitation, Egirdir Bone & Joint Disease Treatment and Rehabilitation Hospital, Isparta, Turkey. · Department of Electrical and Electronics Engineering, Faculty of Engineering, Akdeniz University, Antalya, Turkey. yalbayrak@akdeniz.edu.tr. · Sakarya University, Sakarya, Turkey. yalbayrak@akdeniz.edu.tr. · Sakarya University, Sakarya, Turkey. · Department of Electrical and Electronics Engineering, Faculty of Engineering, Gazi University, Ankara, Turkey. ·Australas Phys Eng Sci Med · Pubmed #27193630.

ABSTRACT: Fibromyalgia syndrome (FMS) is a chronic muscle and skeletal system disease observed generally in women, manifesting itself with a widespread pain and impairing the individual's quality of life. FMS diagnosis is made based on the American College of Rheumatology (ACR) criteria. However, recently the employability and sufficiency of ACR criteria are under debate. In this context, several evaluation methods, including clinical evaluation methods were proposed by researchers. Accordingly, ACR had to update their criteria announced back in 1990, 2010 and 2011. Proposed rule based fuzzy logic method aims to evaluate FMS at a different angle as well. This method contains a rule base derived from the 1990 ACR criteria and the individual experiences of specialists. The study was conducted using the data collected from 60 inpatient and 30 healthy volunteers. Several tests and physical examination were administered to the participants. The fuzzy logic rule base was structured using the parameters of tender point count, chronic widespread pain period, pain severity, fatigue severity and sleep disturbance level, which were deemed important in FMS diagnosis. It has been observed that generally fuzzy predictor was 95.56 % consistent with at least of the specialists, who are not a creator of the fuzzy rule base. Thus, in diagnosis classification where the severity of FMS was classified as well, consistent findings were obtained from the comparison of interpretations and experiences of specialists and the fuzzy logic approach. The study proposes a rule base, which could eliminate the shortcomings of 1990 ACR criteria during the FMS evaluation process. Furthermore, the proposed method presents a classification on the severity of the disease, which was not available with the ACR criteria. The study was not limited to only disease classification but at the same time the probability of occurrence and severity was classified. In addition, those who were not suffering from FMS were evaluated for their conditions in other patient groups.

22 Article Relationship between FokI polymorphism in the vitamin D receptor gene and fibromyalgia syndrome. 2016

Maraslı, Erdem / Ozdolap, Senay / Sarıkaya, Selda. ·Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Bulent Ecevit University, Zonguldak, Turkey. ·Int J Rheum Dis · Pubmed #27135653.

ABSTRACT: AIM: The aim of this study was to evaluate the vitamin D receptor (VDR) gene FokI polymorphism frequencies distribution in subjects with fibromyalgia syndrome (FMS) compared to healthy controls. METHOD: Using a case-control design, 100 female patients, who were diagnosed with FMS according to the American College of Rheumatology criteria and 100 healthy female subjects were enrolled in this study. FokI polymorphisms of the VDR gene were analyzed by restriction fragment length polymorphisms (RFLP) in both groups. RESULTS: No significant differences in the frequencies distribution of both genotype and alleles of the FokI polymorphism in the VDR gene were observed between the two groups. CONCLUSION: The relationship between VDR gene FokI polymorphism and FMS, particularly in Turkish women, could not be determined in this study. However, further studies with larger patient numbers may be needed to prove a relation between VDR gene polymorphism and FMS.

23 Article Physiological parameters as a tool in the diagnosis of fibromyalgia syndrome in females: A preliminary study. 2016

Elmas, Onur / Yildiz, Sedat / Bilgin, Suleyman / Demirci, Seden / Comlekci, Selcuk / Koyuncuoglu, Hasan Rifat / Akkus, Selami / Colak, Omer Halil / Etem Koklukaya, ? / Arslan, Evren / Ozkan, Ozhan / Bilgin, Gurkan. ·Mugla Sitki Kocman University, Faculty of Medicine, Department of Physiology, Mugla 48000, Turkey. Electronic address: onurelmas@outlook.com. · Suleyman Demirel University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Isparta, Turkey. · Akdeniz University, Faculty of Engineering, Department of Electrical and Electronics Engineering, Antalya, Turkey. · Suleyman Demirel University, Department of Electronics and Communication Engineering, Isparta, Turkey. · Suleyman Demirel University, Faculty of Medicine, Department of Neurology, Isparta, Turkey. · Yildirim Beyazit University, Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Ankara, Turkey. · Sakarya University, Faculty of Engineering, Department of Electrical and Electronics Engineering, Sakarya, Turkey. · Mehmet Akif Ersoy University, Burdur Junior Technical College, Burdur, Turkey. ·Life Sci · Pubmed #26685758.

ABSTRACT: AIMS: Although fibromyalgia (FM) syndrome is associated with many symptoms, there is as yet no specific finding or laboratory test diagnostic of this syndrome. The physical examination and laboratory tests may be helpful in figuring out this syndrome. MATERIALS AND METHODS: The heart rate, respiration rate, body temperature (TEMP), height, body weight, hemoglobin level, erythrocyte sedimentation rate, white blood cell count, platelet count (PLT), rheumatoid factor and C-reactive protein levels and electrocardiograms (ECG) of FM patients were compared with those of control individuals. In addition, the predictive value of these tests was evaluated via receiver operating characteristic (ROC) analysis. KEY FINDINGS: The results showed that the TEMP and the PLT were higher in the FM group compared with the control group. Also, ST heights in ECGs which corresponds to a period of ventricle systolic depolarization, showed evidence of a difference between the FM and the control groups. There was no difference observed in terms of the other parameters. According to the ROC analysis, PLT, TEMP and ST height have predictive capacities in FM. SIGNIFICANCE: Changes in hormonal factors, peripheral blood circulation, autonomous system activity disorders, inflammatory incidents, etc., may explain the increased TEMP in the FM patients. The high PLT level may signify a thromboproliferation or a possible compensation caused by a PLT functional disorder. ST depression in FM patients may interrelate with coronary pathology. Elucidating the pathophysiology underlying the increases in TEMP and PLT and the decreases in ST height may help to explain the etiology of FM.

24 Article A Study on the Effects of Sympathetic Skin Response Parameters in Diagnosis of Fibromyalgia Using Artificial Neural Networks. 2016

Ozkan, Ozhan / Yildiz, Murat / Arslan, Evren / Yildiz, Sedat / Bilgin, Suleyman / Akkus, Selami / Koyuncuoglu, Hasan R / Koklukaya, Etem. ·Department of Electrical and Electronics Engineering, Faculty of Engineering, Sakarya University, 54187, Sakarya, Turkey. · Department of Electrical and Electronics Engineering, Faculty of Engineering, Sakarya University, 54187, Sakarya, Turkey. earslan@sakarya.edu.tr. · Physical Medicine and Rehabilitation Clinic, Egirdir Bone & Joint Disease Treatment and Rehabilitation Hospital, Isparta, Turkey. · Department of Electrical and Electronics Engineering, Faculty of Engineering, Akdeniz University, Antalya, Turkey. · Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey. · Department of Neurology, Faculty of Medicine, Suleyman Demirel University, Isparta, Turkey. · Department of Electrical and Electronics Engineering, Faculty of Engineering, Gazi University, Ankara, Turkey. ·J Med Syst · Pubmed #26645318.

ABSTRACT: Fibromyalgia syndrome (FMS), usually observed commonly in females over age 30, is a rheumatic disease accompanied by extensive chronic pain. In the diagnosis of the disease non-objective psychological tests and physiological tests and laboratory test results are evaluated and clinical experiences stand out. However, these tests are insufficient in differentiating FMS with similar diseases that demonstrate symptoms of extensive pain. Thus, objective tests that would help the diagnosis are needed. This study analyzes the effect of sympathetic skin response (SSR) parameters on the auxiliary tests used in FMS diagnosis, the laboratory tests and physiological tests. The study was conducted in Suleyman Demirel University, Faculty of Medicine, Physical Medicine and Rehabilitation Clinic in Turkey with 60 patients diagnosed with FMS for the first time and a control group of 30 healthy individuals. In the study all participants underwent laboratory tests (blood tests), certain physiological tests (pulsation, skin temperature, respiration) and SSR measurements. The test data and SSR parameters obtained were classified using artificial neural network (ANN). Finally, in the ANN framework, where only laboratory and physiological test results were used as input, a simulation result of 96.51 % was obtained, which demonstrated diagnostic accuracy. This data, with the addition of SSR parameter values obtained increased to 97.67 %. This result including SSR parameters - meaning a higher diagnostic accuracy - demonstrated that SSR could be a new auxillary diagnostic method that could be used in the diagnosis of FMS.

25 Article Effects of low sleep quality on sexual function, in women with fibromyalgia. 2016

Amasyali, A S / Taştaban, E / Amasyali, S Y / Turan, Y / Kazan, E / Sari, E / Erol, B / Cengiz, M / Erol, H. ·Adnan Menderes University School of Medicine, Department of Urology, Aydin, Turkey. · Adnan Menderes University School of Medicine, Department of Physical Therapy and Rehabilitation, Aydin, Turkey. · Adnan Menderes University School of Medicine, Department of Algology, Aydin, Turkey. · Balikesir University School of Medicine, Department of Urology, Balikesir, Turkey. · Istanbul Medeniyet University Faculty of Medicine, Department of Urology, Goztepe Kadikoy, Istanbul. · Adnan Menderes University School of Medicine, Department of Biostatistics, Aydin, Turkey. ·Int J Impot Res · Pubmed #26581913.

ABSTRACT: Sexual dysfunction is a common experience in women with fibromyalgia. However, the physiopathology of this association is unclear. We aimed to evaluate whether sleep disturbance has an influence on sexual function in women with fibromyalgia. Fifty-four sexually active premenopausal women with fibromyalgia were enrolled in the study. The following questionnaires were used: the Female Sexual Function Index (FSFI), the Pittsburgh Sleep Quality Index (PSQI), the Fibromyalgia Impact Questionnaire (FIQ) and the Beck Depression Inventory (BDI). Appropriate statistical analyses were used by using SPSS 18. The mean FSFI score was 25.344 ± 6.52 and showed no correlation with age, body mass index, BDI or duration of fibromyalgia. However, a positive correlation between sexual dysfunction and low sleep quality was found (r=0.43; P=0.001). In addition, the median FSFI score was 29.2 (27.2-32.4) in patients with higher sleep quality (PSQI⩽5), whereas it was 21.4 (18.9-25.3) in patients with lower sleep quality (PSQI>5) (P<0.001). There was a positive correlation between sexual dysfunction and symptoms of fibromyalgia as indicated by a higher FIQ score (r=0.37; P=0.006). Sexual dysfunction in female patients with fibromyalgia may be due to low sleep quality. Treatment of the sleep disorder may improve female sexual function.

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