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Fibromyalgia: HELP
Articles from Miscellaneous cities in Turkey
Based on 128 articles published since 2009
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These are the 128 published articles about Fibromyalgia that originated from Miscellaneous cities in Turkey during 2009-2019.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6
1 Review Ultrasound imaging for sarcopenia, spasticity and painful muscle syndromes. 2018

Özçakar, Levent / Ata, Ayşe Merve / Kaymak, Bayram / Kara, Murat / Kumbhare, Dinesh. ·Department of Physical and Rehabilitation Medicine, Hacettepe University Medical School, Ankara. · Department of Physical Medicine and Rehabilitation, Viranşehir State Hospital, Şanlıurfa, Turkey. · Division of Physical Medicine and Rehabilitation, Department of Medicine, University of Toronto, Toronto, Canada. ·Curr Opin Support Palliat Care · Pubmed #29912727.

ABSTRACT: PURPOSE OF REVIEW: On the basis of its various advantages and the relevant awareness of physicians, ultrasound imaging has overwhelmingly taken its place in the scientific arena. This is true both from the side of daily clinical applications and also from the side of research. Yet, ultrasound provides real-time (diagnostic) imaging and (interventional) guidance for a wide spectrum of muscle disorders. In this regard, this review aims to discuss the potential/actual utility of ultrasound imaging in particular muscle disorders, that is, sarcopenia, spasticity and fibromyalgia/myofascial pain syndrome. RECENT FINDINGS: Due to the aging population worldwide and the importance of functionality in the older population, mounting interest has been given to the diagnosis and management of sarcopenia in the recent literature. Likewise, several articles started to report that ultrasound imaging can be used conveniently and effectively in the early diagnosis and quantification of sarcopenia.For spasticity, aside from ultrasound-guided botulinum toxin injections, intriguing attention has been paid to sonographic evaluation of muscle architecture, echogenicity and elasticity in the follow-up of these chronic conditions.As regards painful muscle syndromes, quantitative ultrasound techniques have been shown to detect statistically significant differences between healthy controls and patients with myofascial pain syndrome. SUMMARY: Ultrasound imaging seems to be a promising tool that indisputably deserves further research in the management of a wide range of muscle disorders. VIDEO ABSTRACT: http://links.lww.com/COSPC/A17.

2 Review Advances in diagnostic and treatment options in patients with fibromyalgia syndrome. 2009

Gur, Ali / Oktayoglu, Pelin. ·Department of Physical Medicine and Rehabilitation, Medical Faculty, Gaziantep University, Gaziantep, Turkey. · Department of Physical Medicine and Rehabilitation, Batman State Hospital, Batman, Turkey. ·Open Access Rheumatol · Pubmed #27789991.

ABSTRACT: Fibromyalgia (FM) is characterized as a chronic, painful, noninflammatory syndrome affecting the musculoskeletal system. In addition to pain, common co-morbid symptoms associated with FM include sleep disturbances, fatigue, morning stiffness, affective disorders, chronic daily headache, dyscognition, irritable bowel syndrome, and irritable bladder. Fibromyalgia is usually classified by application of the American College of Rheumatology (ACR) criteria. Although these criteria are accepted among investigators who agree with the concept of fibromyalgia, they do so with some reservations. Tender points and widespread pain alone does not describe the esence of fibromyalgia. New diagnostic tools including either clinical or radiological components are studied to diminish these problems. Although various pharmacological solutions have been studied for treating fibromyalgia, no single drug or groups of drugs have proved to be useful in treating fibromyalgia patients. Recently, three drugs, pregabalin, duloxetine and milnacipran, were approved for the treatment of FM by the US Food and Drug Administration (FDA). Novel therapeutic approaches to the management of FM include cannabinoids, sodium channel blockade and new generation antiepileptics. This review evaluates both new diagnostic tools, including clinical or radiological regimes, and tries to highlight the efficacy of medicinal and nonmedicinal treatments with new therapeutic approaches in the management of FM with a wide perspective.

3 Clinical Trial Cutaneous silent period in fibromyalgia. 2011

Sahin, Ozlem / Yildiz, Serpil / Yildiz, Nebil. ·Department of Physical Medicine and Rehabilitation, Medical Faculty, Cumhuriyet University, Sivas, Turkey. sahinftr@yahoo.com ·Neurol Res · Pubmed #21535931.

ABSTRACT: OBJECTIVES: The pathogenesis of widespread pain and increased tenderness in Fibromyalgia (FM) are still unknown. Recently, the role of central nervous system hyperexcitability is emphasized in pathogenesis of FM. The central sensitization was demonstrated with decrease in nociceptive flexion reflex (NFR) threshold in patients with FM. The NFR and cutaneous silent period (CuSP) are excitatory and inhibitory parts of the same spinal protective reflex, respectively. The aim of this study was to evaluate the changes in CuSP in FM. PATIENTS AND METHODS: Twenty-eight patients with FM and 18 healthy volunteers were subjected to the study. CuSPs on right abductor pollicis brevis muscle evoked by electrical stimulation of the right fifth digit were recorded. RESULTS: The CuSP onset latencies were significantly longer in patients with FM. There was not any significant difference in CuSP duration between patients and controls. CONCLUSION: The latency elongation of the CuSP shows that there is some delay in the development of the inhibitory part of the spinal protective reflex in patients with FM. The observed changes in CuSP of the patients with FM may suggest some abnormalities in the circuits of sensorimotor integration at spinal and supraspinal levels. The results regarding the changes observed in the CuSP in patients with FM should be confirmed by further studies.

4 Article Enthesitis and its relationship with disease activity, functional status, and quality of life in psoriatic arthritis: a multi-center study. 2019

Sunar, Ismihan / Ataman, Sebnem / Nas, Kemal / Kilic, Erkan / Sargin, Betul / Kasman, Sevtap Acer / Alkan, Hakan / Sahin, Nilay / Cengiz, Gizem / Cuzdan, Nihan / Gezer, Ilknur Albayrak / Keskin, Dilek / Mülkoğlu, Cevriye / Resorlu, Hatice / Bal, Ajda / Duruöz, Mehmet Tuncay / Küçükakkaş, Okan / Yurdakul, Ozan Volkan / Melikoglu, Meltem Alkan / Aydın, Yıldıray / Ayhan, F Figen / Bodur, Hatice / Calis, Mustafa / Capkın, Erhan / Devrimsel, Gul / Gok, Kevser / Hizmetli, Sami / Kamanlı, Ayhan / Keskin, Yaşar / Kocabas, Hilal / Kutluk, Oznur / Şen, Nesrin / Şendur, Omer Faruk / Tekeoğlu, Ibrahim / Tolu, Sena / Toprak, Murat / Tuncer, Tiraje. ·Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Ankara University School of Medicine, Hacettepe, Talatpaşa Blv No:82, Altındağ, 06230, Ankara, Turkey. dr.ismihan@gmail.com. · Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Ankara University School of Medicine, Hacettepe, Talatpaşa Blv No:82, Altındağ, 06230, Ankara, Turkey. · Division of Rheumatology and Immunology, Department of Physical Medicine and Rehabilitation, Sakarya University School of Medicine, Sakarya, Turkey. · Rheumatology Clinic, Afyonkarahisar State Hospital, Afyonkarahisar, Turkey. · Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Adnan Menderes University School of Medicine, Aydın, Turkey. · Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Marmara University School of Medicine, Istanbul, Turkey. · Department of Physical Medicine and Rehabilitation, Pamukkale University School of Medicine, Denizli, Turkey. · Department of Physical Medicine and Rehabilitation, Balıkesir University School of Medicine, Balıkesir, Turkey. · Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Erciyes University School of Medicine, Kayseri, Turkey. · Rheumatology Clinic, Van Training and Research Hospital, Van, Turkey. · Rheumatology Clinic, Şanlıurfa Training and Research Hospital, Şanlıurfa, Turkey. · Department of Physical Medicine and Rehabilitation, Selçuk University School of Medicine, Konya, Turkey. · Department of Physical Medicine and Rehabilitation, Kırıkkale University School of Medicine, Kirikkale, Turkey. · Department of Physical Medicine and Rehabilitation, Ankara Training and Research Hospital, Ankara, Turkey. · Department of Physical Medicine and Rehabilitation, Çanakkale Onsekiz Mart University School of Medicine, Çanakkale, Turkey. · Department of Physical Medicine and Rehabilitation, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey. · Department of Physical Medicine and Rehabilitation, Bezmiâlem Foundation University, Istanbul, Turkey. · Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Atatürk University School of Medicine, Erzurum, Turkey. · Department of Physical Theraphy and Rehabilitation, Uşak University, High School of Health Sciences, Uşak, Turkey. · Department of Physical Medicine and Rehabilitation, Yıldırım Beyazıt University School of Medicine, Ankara, Turkey. · Department of Physical Medicine and Rehabilitation, Karadeniz Technical University School of Medicine, Trabzon, Turkey. · Department of Physical Medicine and Rehabilitation, Recep Tayyip Erdoğan University School of Medicine, Rize, Turkey. · Rheumatology Clinic, Ankara Numune Training and Research Hospital, Ankara, Turkey. · Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Cumhuriyet University School of Medicine, Sivas, Turkey. · Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Necmettin Erbakan University Meram School of Medicine, Konya, Turkey. · Division of Rheumatology, Department of Physical Medicine and Rehabilitation, Akdeniz University School of Medicine, Antalya, Turkey. · Rheumatology Clinic, Kartal Dr. Lutfi Kirdar Training and Research Hospital, Istanbul, Turkey. · Department of Physical Medicine and Rehabilitation, Adnan Menderes University School of Medicine, Aydın, Turkey. · Department of Physical Medicine and Rehabilitation, Medipol University School of Medicine, Istanbul, Turkey. · Department of Physical Medicine and Rehabilitation, Yuzuncu Yıl University School of Medicine, Van, Turkey. ·Rheumatol Int · Pubmed #31773391.

ABSTRACT: Psoriatic arthritis (PsA) is an inflammatory arthritis with distinct phenotypic subtypes. Enthesitis is assigned as a hallmark of the disease, given its significant relations to disease activity and quality of life. Our objective is to evaluate the prevalence of enthesitis and its association with some clinical parameters, particularly quality of life, using data from a national registry. Patients with PsA meeting ClASsification criteria for Psoriatic Arthritis (CASPAR) were enrolled by means of a multi-centre Turkish League Against Rheumatism (TLAR) Network Project. The following information was recorded in web-based case report forms: demographic, clinical and radiographic data; physical examination findings, including tender and swollen joint counts (TJC and SJC); nail and skin involvement; Disease Activity Score-28 for Rheumatoid Arthritis with Erythrocyte Sedimentation Rate (DAS 28-ESR); Bath Ankylosing Spondylitis Disease Activity Index (BASDAI); Maastricht Ankylosing Spondylitis Enthesitis Score (MASES); Psoriasis Area Severity Index (PASI); Bath Ankylosing Spondylitis Radiology Index for the spine (BASRI-s); Health Assessment Questionnaire (HAQ); Bath Ankylosing Spondylitis Functional Index (BASFI); Health Assessment Questionnaire for the spondyloarthropathies (HAQ-s); Psoriatic arthritis quality of Life scale (PsAQoL); Short Form 36 (SF-36); Hospital Anxiety Depression Scale (HADS); Functional Assessment of Chronic Illness Therapy-Fatigue (FACIT-F); and Fibromyalgia Rapid Screening Tool (FiRST) scores. The patients were divided into two groups, namely with and without enthesitis, based on the triple Likert-type physician-reported statement of 'active enthesitis', 'history of enthesitis' or 'none' in the case report forms. Patients with active enthesitis were compared to others in terms of these clinical parameters. A total of 1130 patients were enrolled in this observational study. Of these patients, 251 (22.2%) had active enthesitis according to the clinical assessment. TJC, HAQ-s, BASDAI, FiRST and PsAQoL were significantly higher whereas the SF-36 scores were lower in patients with enthesitis (p < 0.05). Chronic back pain, dactylitis, and tenosynovitis were more frequent in the enthesopathy group (59.4%/39%, 13.1%/6.5% and 24.7%/3.4%, respectively). Significant positive correlations between the MASES score and the TJC, HAQ, DAS 28-ESR, BASDAI, FiRST and PsAQoL scores, and a negative correlation with the SF-36 score were found. When linear regression analysis was performed, the SF-36 MCS and PCS scores decreased by - 9.740 and - 11.795 units, and the FiRST scores increased by 1.223 units in patients with enthesitis. Enthesitis is an important involvement of PsA with significant relations to quality of life determined with PsAQoL and SF-36 scores. Our study found higher frequency of dactylitis and chronic back pain, and worse quality of life determined with SF-36 and PsAQoL scores in patients with enthesitis.

5 Article The Relationship of Intimate Partner Violence With Psychiatric Disorders and Severity of Pain Among Female Patients With Fibromyalgia. 2019

Gündüz, Nermin / Erzincan, Erkal / Polat, Aslıhan. ·Department of Psychiatry, Kütahya University of Health Sciences, Kütahya, Turkey. · Department of Psychiatry, Erenköy Mental Health Neurology Training and Research Hospital, İstanbul, Turkey. · Department of Psychiatry, Kocaeli University Faculty of Medicine, Kocaeli, Turkey. ·Arch Rheumatol · Pubmed #31598588.

ABSTRACT: Objectives: This study aims to compare the prevalence of intimate partner violence and comorbid psychiatric disorders among patients with fibromyalgia syndrome (FMS) and healthy controls and also to investigate the relationship of intimate partner violence with psychiatric disorders and severity of pain in FMS patients. Patients and methods: The study group consisted of 136 females including 68 patients with FMS (mean age 43±10.4 years; range, 25 to 70 years) and 68 FMS-free healthy females (mean age 38.5±11.3 years; range, 22 to 70 years). Following a Structured Clinical Interview for Diagnostic and Statistical Manual-IV Axis I Disorders by a psychiatrist experienced in psychological trauma, Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Visual Analog Scale (VAS) for the severity of pain and Domestic Violence Against Women Scale (DVAWS) were applied. Results: In FMS group, 85% of the patients were diagnosed with mood or anxiety disorder. Almost half of these patients had major depressive disorder. The total scores of DVAWS and all subscales were significantly higher in the FMS group than in the control group (p<0.01). The severity of domestic violence were related to the presence of any psychiatric disorder only in FMS patients (p<0.01). Almost half of the FMS patients with high DVAWS score had comorbid mood and anxiety disorders. There was a significant positive correlation between the total scores of DVAWS, HDRS, HARS, and VAS (p<0.01). Conclusion: Although the etiology of FMS is still uncertain, psychosocial factors may play role as risk factors. Therefore, a multidisciplinary approach to the treatment should be considered.

6 Article Cerebral hemodynamics in patients with ankylosing spondylitis. 2019

Utku, Uygar / Cetin, Gözde / Atilla, Nurhan / Gisi, Kadir / Gökce, Mustafa. ·Department of Neurology, Faculty of Medicine, Kahramanmaras Sutcu Imam University, Kahramanmaras, Turkey. · Department of Internal Diseases Division of Rheumatology, Kahramanmaras, Turkey. · Department of Chest Diseases, Kahramanmaras, Turkey. · Department of Internal Diseases, Kahramanmaras, Turkey. ·J Back Musculoskelet Rehabil · Pubmed #31561322.

ABSTRACT: OBJECTIVE: The aim of this study was to assess the cerebral blood flow velocity as a marker by using transcranial Doppler (TCD) ultrasonography in patients with ankylosing spondylitis (AS). METHODS: A total of 30 patients aged 20 to 50 with AS were enrolled in the AS group (male/female: 4/26, mean age: 34.7 ± 5.9) consecutively. The control group (non-AS group; male/female: 4/26, mean age: 32.3 ± 4.7) consisted of 30 age- and sex-matched, randomly selected patients without AS who had other diagnoses such as fibromyalgia and did not have risk factors for atherosclerosis. Bilateral middle cerebral artery (MCA) peak-systolic, end-diastolic, and mean blood flow velocities, Gosling's pulsatility index values, and Pourcelot's resistance index values were recorded with TCD by a neurosonologist blinded to the AS and control groups. RESULTS: The erythrocyte sedimentation rate (ESR), C-reactive protein (CRP) levels and cerebral blood flow velocities of bilateral MCA were significantly higher in the AS group than in the control group. CONCLUSIONS: This study highlights that the increased cerebral blood flow is indirectly associated with atherosclerosis regarding persistent inflammation in patients with AS.

7 Article The Impact of Fibromyalgia Comorbidity on Patients with Migraine? 2019

Önder, Halil. ·Yozgat State Hospital, Neurology Clinic, Yozgat, Turkey. ·Noro Psikiyatr Ars · Pubmed #31523154.

ABSTRACT: -- No abstract --

8 Article Is Fibromyalgia Syndrome a Neuropathic Pain Syndrome? 2019

Kösehasanoğullari, Meryem / Erdinç Gündüz, Nihan / Akalin, Elif. ·Department of Physical Therapy and Rehabilitation, Uşak Training and Research Hospital, Uşak, Turkey. · Department of Physical Therapy and Rehabilitation, İzmir University of Health Sciences Tepecik Training and Research Hospital, İzmir, Turkey. · Department of Physical Therapy and Rehabilitation, İzmir Dokuz Eylul University Medical Faculty, İzmir, Turkey. ·Arch Rheumatol · Pubmed #31497766.

ABSTRACT: Objectives: This study aims to investigate whether fibromyalgia syndrome (FMS) represents a neuropathic pain syndrome through the use of neuropathic pain scales. Patients and methods: The study included 99 female patients (mean age 44.21 years; range, 18 to 65 years) who referred to Physical Therapy and Rehabilitation Department Outpatient Clinics with complaints of widespread pain and who received a clinical diagnosis of fibromyalgia based on the 1990 American College of Rheumatology diagnostic criteria and a control group consisting of 86 female patients (mean age 49.21 years; range, 18 to 65 years) who were diagnosed with acute subacromial impingement as a nociceptive pain model. All patients completed the Turkish version of the Fibromyalgia Impact Questionnaire (FIQ), the Beck Depression Scale (BDS), the 10 cm Visual Analog Scale for pain assessment, the Leeds Assessment of Neuropathic Symptoms and Signs (LANSS) pain questionnaire for neuropathic pain assessment and the painDETECT scale. Results: An evaluation of the patients' symptoms indicated that complaints of numbness, burning, tingling, morning stiffness, insomnia, fatigue and weakness were significantly more common in the fibromyalgia group compared to the controls. Moreover, the mean scores of the BDS, FIQ, painDETECT and LANSS pain scale were significantly higher in the fibromyalgia group compared to the controls. Statistically significant correlations were noted between FIQ values and LANSS, and the BDS and painDETECT results in the fibromyalgia group. Conclusion: The present study demonstrates that sensorial symptoms such as paraesthesia, hyperalgesia and allodynia were more common and the scores of neuropathic pain scales such as painDETECT and LANSS were significantly elevated in the fibromyalgia patients compared to the control group, and these findings suggest that FMS may have a neuropathic pain component.

9 Article The Impact of Perceived Social Support on Anxiety, Depression and Severity of Pain and Burnout Among Turkish Females With Fibromyalgia. 2019

Gündüz, Nermin / Üşen, Ahmet / Aydin Atar, Emel. ·Department of Psychiatry, Dumlupinar University Faculty of Medicine, Kütahya, Turkey. · Department of Physical Therapy and Rehabilitation, Bezmiâlem Vakıf University, İstanbul, Turkey. · Department of Physical Therapy and Rehabilitation, İstanbul Sultan Abdulhamit Han Training and Research Hospital, İstanbul, Turkey. ·Arch Rheumatol · Pubmed #31497765.

ABSTRACT: Objectives: This study aims to assess the impact of perceived social support on burnout, severity of pain and comorbid anxiety and depression among Turkish females with fibromyalgia syndrome (FMS). Patients and methods: A total of 117 females including 65 patients with FMS (mean age 33.5±8.1 years; range 20 to 60 years) and 52 healthy controls (mean age 33.6±7.3 years; range 23 to 48 years) were included between January 2017 and May 2017. Following a semi-structured psychiatric interview by a psychiatrist, Sociodemographic Data Form, Mood and Anxiety Disorders Modules of Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders fourth edition Axis I Disorders (SCID-I), Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), Visual Analog Scale (VAS), Maslach Burnout Inventory (MBI) and Multidimensional Scale of Perceived Social Support (MSPSS) were applied to participants. Results: As a result of the semi-structured clinical interview conducted by a psychiatrist, the prevalence of any mood or anxiety disorder was found to be significantly more common in the FMS group. The proportion of patients diagnosed with any mood or anxiety disorder using SCID-I was significantly different among FMS (n=50, 76.92%) and healthy control (n=14, 33.33%) groups (p<0.001). Correlations between these variables were examined within the FMS group. There was a significant negative correlation between VAS and MSPSS. There were significant negative correlations between MSPSS and HDRS, HARS, all subscales of MBI. There were significant positive correlations between VAS and HDRS, HARS, all subscales of MBI. Conclusion: In conclusion, perceived social support was found to be strongly associated with depression, anxiety, burnout and severity of pain in patients with FMS. Our study provided support to emphasize the importance of perceived social support among females with FMS. Considering that FMS is associated with many physical and cognitive complaints in addition to pain, it can be considered as a multi-systemic disease requiring a multidisciplinary approach.

10 Article Pro-inflammatory Cytokines and Oxidized Low-Density-Lipoprotein in Patients With Fibromyalgia. 2019

Kutu, Funda Canpolat / Özdolap, Şenay / Sarikaya, Selda. ·Department of Physical Medicine and Rehabilitation, Çaycuma State Hospital, Zonguldak, Turkey. · Department of Physical Medicine and Rehabilitation, Medicine Faculty of Bülent Ecevit University, Zonguldak, Turkey. ·Arch Rheumatol · Pubmed #31497758.

ABSTRACT: Objectives: This study aims to evaluate the differences in serum levels of tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), (IL-8), and oxidized low-density lipoprotein (Ox-LDL) between female fibromyalgia (FM) patients and healthy females and also to examine a possible relationship between the cytokines/biomarker and the severity of pain and clinical features of FM. Patients and methods: This case-control study included 48 female patients (mean age 26.51±6.98 years; range, 18 to 50 years) who were diagnosed with FM according to the American College of Rheumatology criteria and 43 healthy female subjects (mean age 23.93±4.22 years; range, 18 to 50 years). Serum levels of TNF-α, IL-1β, IL-8, and Ox-LDL were measured by enzyme-linked immunosorbent assay in both groups. Fibromyalgia Impact Questionnaire, Visual Analog Scale, symptom severity scale, and widespread pain index were carried out and also their relationships with TNF-α, IL-1β, IL-8, and Ox-LDL levels were evaluated. Results: There was no difference in levels of the serum TNF-α, IL-1β, IL-8, and Ox-LDL between FM patients and healthy controls (p>0.05). The severity of pain was significantly associated with TNF-α (r=0.338; p=0.021) and IL-8 (r=0.299; p=0.043) levels, and Ox-LDL (r=0.415; p=0.006) level was found to be related to symptom severity of FM. Conclusion: Our results suggest that serum levels of TNF-α and IL-8 may be involved in the occurrence of pain in FM. The level of Ox-LDL may play an important role in the severity of symptoms. Future studies are needed to determine whether and how Ox-LDL plays a role in FM.

11 Article Evaluation of the effects of neural therapy in patients diagnosed with fibromyalgia. 2019

Altınbilek, Turgay / Terzi, Rabia / Başaran, Aynur / Tolu, Sena / Küçüksaraç, Seher. ·Department of Physiotherapy and Rehabilitation, İstanbul Kültür University, Faculty of Health Sciences, İstanbul, Turkey. · Department of Physical Therapy and Rehabilitation, Kocaeli Derince Training and Research Hospital, Kocaeli, Turkey. · Department of Physical Therapy and Rehabilitation, Special Özlem Physical Therapy and Rehabilitation Center, Konya, Turkey. · Department of Physical Therapy and Rehabilitation, Bezmialem Foundation University, İstanbul, Turkey. · Department of Physical Therapy and Rehabilitation, Beyhekim State Hospital, Konya, Turkey. ·Turk J Phys Med Rehabil · Pubmed #31453538.

ABSTRACT: Objectives: This study aims to compare the effects of neural therapy and exercise on pain, quality of life, depression, anxiety, and functioning status in patients diagnosed with fibromyalgia syndrome (FMS). Patients and methods: This multi-center study included a total of 72 patients (60 females, 12 males; mean age: 39.2±9.5 years; range, 22 to 53 years) who were diagnosed with FMS according to the 1990 American College of Rheumatology (ACR) criteria between January 2015 and June 2015. The patients were randomly divided into two groups: the first group (n=30) received an exercise program (strengthening, stretching, relaxation, and aerobic exercises, three days a week), and the second group (n=42) received a total of six sessions of neural therapy as one session a week in addition to the same exercise program. Pain severity was assessed with the Visual Analog Scale (VAS), emotional state with the Beck Depression Scale (BDS) and Beck Anxiety Inventory (BAI), quality of life with Short Form-36 (SF-36), and functioning status with the Fibromyalgia Impact Questionnaire (FIQ). The patients were evaluated at the end of treatment (week 6) and one month after the end of treatment. Results: The mean disease duration was 34.3±9.3 months, the mean VAS score was 7.3±2.2, and the mean FIQ score was 58.4±13.2. There were significant improvements in the VAS, FIQ, SF-36, BDS, and BAI scores after the treatment in both groups (p<0.05). Post-treatment BDS and VAS scores were significantly lower in the neural therapy group (p=0.038; p=0.049; p<0.05). There was no significant difference in any parameter one month after the treatment between the groups (p>0.05). Conclusion: When neural therapy is combined with exercise in FMS patients, it may be advantageous in terms of pain and depression, compared to exercise alone.

12 Article The important role of central sensitization in chronic musculoskeletal pain seen in different rheumatic diseases. 2019

Guler, Mehmet Akif / Celik, Omer Faruk / Ayhan, Fikriye Figen. ·Department of Physical Medicine and Rehabilitation, Gaziosmanpasa Taksim Training and Research Hospital, Mevlana District, 884. Street No: 23, 34255 Gaziosmanpasa, Istanbul, Turkey. makifguler89@gmail.com. · Department of Physical Medicine and Rehabilitation, Divisions of Rheumatology, Pain Medicine, Health Sciences University, Ankara Training and Research Hospital, Ankara, Turkey. · Department of Physical Therapy and Rehabilitation, Usak University, High School of Health Sciences, Usak, Turkey. ·Clin Rheumatol · Pubmed #31446538.

ABSTRACT: OBJECTIVE: This study explored the role of central sensitization (CS) pain in patients with various rheumatic diseases using the CS inventory (CSI). METHODS: A total of 193 patients of mean age 50.72 ± 9.65 years were included; they were divided into four different groups in terms of their rheumatic diseases. Patients with rheumatoid arthritis (RA), spondyloarthropathy (SpA), osteoarthritis (OA), and fibromyalgia syndrome (FMS) were evaluated in tertiary care rheumatology/pain medicine settings. Disease duration and activity, the Bath Ankylosing Spondylitis Disease Activity Index, the Disease Activity Score-28, and pain severity (evaluated using a visual analog scale) were assessed, and the Turkish version of the CSI administered. RESULTS: CS syndromes were present in almost half the patients (45% of SpA, 41% of RA, 62% of OA, and 94% of FMS patients). We found no significant relationship between disease activity and the CSI-A scores in SpA or RA patients (p = 0.731 and p = 0.390, respectively). As expected, the CSI-A scores were highest in the FMS group (p = 0.000), but were similar in the other groups (p < 0.05). CS-related syndromes (CSI-B conditions) were present at similar frequencies in the RA, SpA, and OA groups, but were less common in the FMS group (p = 0.000). CONCLUSIONS: The CSI usefully detects CS pain in patients with rheumatic diseases. Treatment of such pain can enhance the quality of daily life in patients with rheumatic diseases.Key Point• Central sensitization pain is common in patients with rheumatic diseases including rheumatoid arthritis, spondyloarthropathies, and osteoarthritis.

13 Article Comorbid fibromyalgia in migraine patients: clinical significance and impact on daily life. 2019

Onder, Halil / Hamamci, Mehmet / Alpua, Murat / Ulusoy, Ersin Kasım. ·Neurology Clinic, Yozgat City Hospital , Yozgat , Turkey. · Department of Neurology, Bozok University Medical School , Yozgat , Turkey. · Department of Neurology, Kırıkkale University Medical School , Kırıkkale , Turkey. · Neurology Clinic, Kayseri Training and Research Hospital , Kayseri , Turkey. ·Neurol Res · Pubmed #31221031.

ABSTRACT:

14 Article Migraine in patients with fibromyalgia and outcomes of greater occipital nerve blockage. 2019

Yilmaz, Volkan / Aras, Berke / Erturk, Fatma Avsar / Cakcı, Fatma Aytul / Umay, Ebru. ·Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Ankara, Turkey. Electronic address: dryilmazv@hotmail.com. · Kastamonu Rehabilitation Center Hospital, Physical Medicine and Rehabilitation Clinic, Kastamonu, Turkey. · Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Neurology Clinic, Ankara, Turkey. · Ankara Diskapi Yildirim Beyazit Training and Research Hospital, Physical Medicine and Rehabilitation Clinic, Ankara, Turkey. ·Clin Neurol Neurosurg · Pubmed #30991338.

ABSTRACT: OBJECTIVES: The aim of this study is to evaluate the efficacy of greater occipital nerve (GON) blockage in patients with migraine and fibromyalgia (FM) comorbidity. PATIENTS AND METHOD: 20 patients who were diagnosed as FM according to 2010 American College of Rheumatology (ACR) diagnostic criteria and migraine according to International Classification of Headache Disorers II criteria and did not recieve any medication or GON block for both disorders were included for the study. GON blocks were repeated every week in the first month and repeated montly for the following 2 months. The frequency and duration of the migraine attacks, pain severity with visual analogue scale (VAS), quality of life (QoL) with revised fibromyalgia impact questionnaire (FIQR) and migraine disability assesment questionnaire (MIDAS) before,1 st month and 3rd months after treatment were recorded and compared. RESULTS: 95% of 20 patients were female (n = 19) and 5% was male (n = 1). The affected site was left in 60% of the patients (n = 12) and 40% was right (n = 8). There was significant improvement in terms of all evaluation parameters both at 1 st month and 3rd months after treatment compared to the baseline. Likely, all parameters were significantly improved at 3rd month compared to the 1 st month. CONCLUSIONS: GON blockage reduces pain severity, headache frequency and duration and increases QoL in patients with migraine and FM comorbidity.

15 Article Alteration of Thiol-Disulfide Homeostasis in Fibromyalgia Syndrome. 2019

Tuzcu, Ayca / Baykara, Rabia Aydogan / Alışık, Murat / Omma, Ahmet / Acet, Gunseli Karaca / Dogan, Erdal / Cure, Medine Cumhur / Duygun, Fatih / Cure, Erkan / Erel, Ozcan. ·Department of Biochemistry, Malatya Education and Research Hospital, Malatya, Turkey. · Department of Physical Medicine and Rehabilitation, Malatya Education and Research Hospital, Malatya, Turkey. · Department of Clinical Biochemistry, Ankara Education and Research Hospital, Ankara, Turkey. · Division of Rheumatology, Department of Internal Medicine, Numune Education and Research Hospital, Ankara, Turkey. · Department of Biochemistry, Istanbul Laboratory, Istanbul, Turkey. · Departments of Orthopedics and Traumatology, Antalya Training and Research Hospital, Antalya, Turkey. · Department of Internal Medicine, Camlica Erdem Hastanesi, Istanbul, Turkey. erkancure@yahoo.com. · Department of Clinical Biochemistry, Faculty of Medicine, Yildirim Beyazit University, Ankara, Turkey. ·Acta Medica (Hradec Kralove) · Pubmed #30931891.

ABSTRACT: BACKGROUND: Fibromyalgia syndrome (FMS) is an extra-articular rheumatological disease, characterized by widespread pain and somatic symptoms. The etiology has not yet been clarified. Oxidative stress may play an important role in FMS etiology. Thiol group is a very strong antioxidant. We aimed to investigate whether thiol/disulfide homeostasis in FMS is altered or not. MATERIAL AND METHODS: A total of 80 female FMS patients and 64 healthy female control individuals were included in this study. Thiol and disulfide values were measured by Erel's novel methods. RESULTS: Native thiol (330.6 ± 46.1 vs. 356.8 ± 55.5 μmol/L, p = 0.005) and native thiol/total thiol (89.4 ± 3.2 vs. 93.3 ± 4.0, p < 0.001) levels of FMS patients were significantly lower when compared to the values of control group. However, disulfide (19.4 ± 6.3 vs. 12.2 ± 6.3 μmol/L, p < 0.001) levels of FMS patients were significantly higher than healthy individuals. A negative correlation was found between the native thiol/total thiol and fibromyalgia impact questionnaire (FIQ) score among the FMS patients. A positive correlation was found between disulfide values and FIQ score among the patients. CONCLUSIONS: In FMS patients, there was a significant correlation between the decrease in the thiol levels and an increase in the disulfide levels with the FIQ scores. We determined that thiol-disulfide rate was deteriorated in FMS patients and it increases in favor of disulfide amounts.

16 Article Evaluation of carotid-femoral pulse wave velocity, aortic stiffness index, and aortic distensibility in patients with fibromyalgia. 2019

Gunturk, Ertugrul Emre / Ekiz, Timur / Akkaya, Hasan. ·Faculty of Medicine, Department of Cardiology, Nigde Omer Halisdemir University, Nigde, Turkey. ertugrulemre@yahoo.com. · Nigde Omer Halisdemir Universitesi Merkez Yerleşkesi, Tip Fakültesi Kardiyoloji Anabilim Dalı, Bor Yolu Uzeri, 51240, Merkez/Nigde, Turkey. ertugrulemre@yahoo.com. · Turkmenbası Medical Center, Department of Physical and Rehabilitation Medicine, Adana, Turkey. · Faculty of Medicine, Department of Cardiology, Nigde Omer Halisdemir University, Nigde, Turkey. ·Clin Rheumatol · Pubmed #30635854.

ABSTRACT: OBJECTIVE: The aim of this study was to compare the carotid-femoral pulse wave velocity (CFPWV), aortic stiffness index (ASI), and aortic distensibility values of fibromyalgia patients with those of healthy subjects. METHODS: This study was conducted as a case-control study between September 2017 and March 2018. Echocardiographic evaluations were administered by the same cardiologist. ASI, aortic distensibility, CFPWV, and other echocardiographic parameters of fibromyalgia patients and healthy subjects were compared. In addition, all patients were assessed using the Fibromyalgia Impact Questionnaire (FIQ), number of tender points, and Visual Analogue Scale (VAS) pain score. RESULTS: The fibromyalgia group consisted of 67 female patients with a mean age of 48.54 ± 3.1 years (range, 42-55 years) and the control group consisted of 50 healthy subjects with a mean age of 49.76 ± 3.1 years (range, 42-55 years). No significant difference was observed between the groups in respect of age and body mass index (p > 0.05). CFPWV and ASI values were significantly higher in the fibromyalgia group than in the control group. Aortic distensibility values were significantly lower in the fibromyalgia group compared to the control group (p < 0.05 for all). There was a very strong, positive correlation between the CFPWV values and number of tender points (r = 0.936, p < 0.001), VAS (r = 0.927, p < 0.001), FIQ (r = 0.941, p < 0.001), and ASI (r = 0.957, p < 0.001). CONCLUSION: CFPWV and aortic stiffness seem to be increased and aortic distensibility seems to be decreased in patients with fibromyalgia. Alleviating pain and improving the disease severity may be helpful in preventing cardiovascular risk factors in patients with fibromyalgia.

17 Article The association between fibromyalgia and female sexual dysfunction: a systematic review and meta-analysis of observational studies. 2019

Besiroglu, M D Huseyin / Dursun, M D Murat. ·Department of Urology, Catalca Ilyas Cokay State Hospital, Istanbul, Turkey. drhuseyin1985@hotmail.com. · Department of Urology, Malatya Training and Research Hospital, Malatya, Turkey. ·Int J Impot Res · Pubmed #30467351.

ABSTRACT: Female sexuality in patients with fibromyalgia has received little attention in the literature, and published data have mainly relied upon a small sample size with evident heterogeneity. Our aim was to pool the observational studies on the association between fibromyalgia and sexual dysfunction in female patients to reach a more comprehensive and reliable result. The literature search comprised of Pubmed-Medline, Cochrane, and Embase databases. The relevant studies that met the inclusion criteria were gathered and the pooled effect size was calculated. The standard mean difference of the global sexual function score as well as the sub-items scores were calculated using the random-effect size model. Sensitivity analysis was conducted. Publication bias was assessed using Funnel plots and Begg and Mazumdar rank correlation tests. The meta-analysis was conducted in accordance with the MOOSE guideline. The six selected studies contained 919 participants (ranging from 51 to 362). Of those, 578 were patients with fibromyalgia, and 341 were the controls. While four studies evaluated the sexual function using the female sexual function index (FSFI) questionnaire, two used changes in the sexual functioning questionnaire (CSFQ). Patients with fibromyalgia had a decreased total sexual function score [(-5.02 (-7.58 to -2.46), p < 0.0001; Q = 664.28; p-value for heterogeneity = p < 0.0001; I

18 Article Assessment of hand function and disability in fibromyalgia. 2019

Devrimsel, G / Turkyilmaz, A K / Beyazal, M S / Karkucak, M. ·Department of Physical Medicine and Rehabilitation, Recep Tayyip Erdogan University Medical School, Rize, Turkey. gdevrimsel@gmail.com. · Department of Physical Medicine and Rehabilitation, Recep Tayyip Erdogan University Medical School, Rize, Turkey. ·Z Rheumatol · Pubmed #30324279.

ABSTRACT: OBJECTIVE: Fibromyalgia, a potentially debilitating chronic pain syndrome, is a chronic disease. We aimed to compare the hand function of fibromyalgia (FM) patients and healthy individuals and to demonstrate the relationship between hand disability and FM. PATIENTS AND METHODS: The study was consisted of 40 female patients with FM and 30 healthy controls. All participants were evaluated for pain threshold measurements, handgrip strength, and pinch strength. Functional states, hand disability, and hand skills and coordination were evaluated using the Fibromyalgia Impact Questionnaire (FIQ) form, the Disability of Arm-Shoulder-Hand (DASH) questionnaire and the Purdue Pegboard Test, respectively. RESULTS: Handgrip strength values, DASH score, lateral pinch strength test, Pegboard placement time, and Pegboard collection time of the patient group were significantly lower than those of the control group (all p < 0.05). A negative correlation was found between FIQ score and handgrip strength, two-point pinch strength test, three-point pinch strength test, and lateral pinch strength test in patients with moderate FM (all p < 0.05). Furthermore, a correlation was observed between DASH score and handgrip strength, lateral pinch strength test, Purdue Pegboard placement time, and Purdue Pegboard collection time in patients with moderate FM (all p < 0.05). CONCLUSIONS: Our results show that hand function was decreased in patients with FM compared to healthy controls and decreasing hand function was influenced by FIQ score. As a result, the evaluation of hand function should be taken into consideration in the management of FM.

19 Article Evaluation of rational drug use knowledge level in patients with musculoskeletal disorders. 2019

Arikan, İnci / Özyigit, Filiz. ·Department of Public Health, Medical Faculty of Kütahya Health Sciences University, Kütahya 43100, Turkey. · Department of Pharmacology, Medical Faculty of Kütahya Health Sciences University, Kütahya 43100, Turkey. ·J Back Musculoskelet Rehabil · Pubmed #30248041.

ABSTRACT: BACKGROUND: For treatment of chronic musculoskeletal disorders pains to be successful, drug interventions are required. OBJECTIVE: In this study, we aimed to evaluate the Rational Drug Use Knowledge Level (RDUKL) in patients with musculoskeletal disorders and some relevant factors. METHOD: The study was carried out in October 2017 on patients treated in the Physical Therapy Rehabilitation Hospital in Turkey. The prepared questionnaire and RDUKL scale were administered to 239 patients by face-to-face interviews. The ANOVA test, chi-squared test and logistic regression model were used for the statistical evaluation. RESULTS: Forty-three percent of the study group was found to have Rational Drug Use Knowledge (RDUK). The patients who used medicines under family supervision had twice as much RDUK as those who did not use medicines under family supervision, and those who were university graduates had six times as much RDUK as those who had primary education or below. Scale score was found to be low in patients with fibromyalgia and high in patients with rheumatoid arthritis (p< 0.05). CONCLUSION: RDUKL was found to be low in the group with chronic diseases and high average age. Besides training, it is important to provide patients with family support about their illness and its treatment. Thus, positive contributions can be made to the increase of the RDUKL.

20 Article Psychiatric comorbidity and childhood trauma in fibromyalgia syndrome. 2018

Gündüz, Nermin / Polat, Aslıhan / Erzincan, Erkal / Turan, Hatice / Sade, Ilgın / Tural, Ümit. ·Department of Psychiatry, Dumlupınar University School of Medicine Kütahya Evliya Çelebi Training and Research Hospital, Kütahya, Turkey. · Department of Psychiatry, Kocaeli University School of Medicine, Kocaeli, Turkey. · Department of Psychiatry, Erenkoy Mental Health and Psychiatry Training and Research Hospital, İstanbul, Turkey. · Department of Psychiatry, İstanbul Moodist Psychiarty and Neurology Hospital, İstanbul, Turkey. · Department of Physical Medicine and Rehabilitation, Kocaeli University School of Medicine, Kocaeli, Turkey. ·Turk J Phys Med Rehabil · Pubmed #31453497.

ABSTRACT: Objectives: In this study, we aimed to compare patients with fibromyalgia syndrome (FMS) and those with myofascial pain syndrome (MPS) and healthy women and to investigate the prevalence of childhood traumatic experiences (CTEs) in relation to comorbid mood and anxiety disorders. Patients and methods: Between February 2014 and May 2014, a total of 136 women including 52 with FMS, 35 with MPS, and 49 healthy controls were included in the study. The Sociodemographic Data Form, Mood and Anxiety Disorders Modules of Structured Clinical Interview for Diagnostic and Statistical Manual of Mental Disorders fourth edition (DSM-IV) Axis I Disorders (SCID-I), Fibromyalgia- related Symptom Scale (FSS), Hamilton Depression Rating Scale (HDRS), Hamilton Anxiety Rating Scale (HARS), and Childhood Trauma Questionnaire-28 (CTQ-28) were applied to participants. Results: As a result of the semi-structured clinical interview conducted by a psychiatrist experienced in psychological trauma, the prevalence of any mood or anxiety disorder were found to be significantly more common in the FMS group. Childhood traumatic experiences, not only in general, but also with all subtypes, were also reported to be significantly more in FMS patients. Besides, only in patients with FMS, a significant relationship was found between the psychiatric diagnoses and the presence of CTEs. Furthermore, the CTQ-28 scores were correlated positively with the FSS scores as well as HDRS and HARS. Among the symptoms screened by the FSS, only crying and over-reacting to incidents were significantly associated with CTEs in FMS group. Conclusion: Based on our study results, CTEs may play a critical role in the development of fibromyalgia and may be related with comorbid mood and anxiety disorders in FMS patients. Associating psychological symptoms such as crying or over-reacting to incidents in FMS patients should be, therefore, alerting for psychiatric consultation.

21 Article Relationship of leptin, growth hormone, and insulin-like growth factor levels with body mass index and disease severity in patients with fibromyalgia syndrome. 2018

Koca, Tuba Tülay / Berk, Ejder / Seyithanoğlu, Muhammet / Koçyiğit, Burhan Fatih / Demirel, Adnan. ·Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey. tuba_baglan@yahoo.com. · Faculty of Medicine, Department of Physical Medicine and Rehabilitation, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey. · Faculty of Medicine, Department of Biochemistry, Kahramanmaraş Sütçü İmam University, Kahramanmaraş, Turkey. · Physical Medicine and Rehabilitation Clinic, Bingöl State Hospital, Bingöl, Turkey. ·Acta Neurol Belg · Pubmed #30547374.

ABSTRACT: OBJECTIVE: A high prevalence of obesity in fibromyalgia syndrome (FMS) predisposes patients to metabolic changes. It is not clear how the clinical manifestations of the disease affect metabolism. This study aimed to investigate leptin, growth hormone (GH), and insulin-like growth factor (IGF-1) levels in FMS, and their relationship with body mass index (BMI) and disease severity. METHOD: This case-control study included 60 patients with FMS and 42 age- and sex-matched healthy controls. BMIs were recorded for all participants. The disease severity was assessed using the Fibromyalgia Impact Questionnaire (FIQ) and a visual analog scale (VAS). The serum levels of leptin, GH, and IGF-1 of all participants were measured using specific enzyme-linked immunosorbent assays. RESULTS: Both groups had similar age (p = 0.058), sex (p = 0.25), and BMI (p = 0.29) distribution. The mean age of the FMS and the control groups was 40.7 ± 10.8 years and 36.2 ± 13.6 years, respectively. The mean BMI was 26.7 kg/m CONCLUSION: We found that leptin (high), GH (low), and IGF-1 (low) levels were statistically different, together with being independent of disease severity (FIQ, VAS), and correlated with BMI in the FMS group. These findings may be related with hypothalamo-pituitary axis dysfunction, BMI, and energy metabolism.

22 Article A probable case of movement disorder (Tardive dyskinesia) due to duloxetine treatment. 2018

Yılmaz, Resul / Üstün, Damlanur / Tuncer Uzun, Sema / Reisli, Ruhiye / Türk, Şeyda. ·Department of Anesthesiology and Reanimation, Zile State Hospital, Tokat, Turkey. dr.r.yilmaz@gmail.com. ·Agri · Pubmed #30403275.

ABSTRACT: Tardive dyskinesia and tardive dystonia are caused by dopamine receptor blocking agents, mostly antipsychotics and sometimes antidepressants or calcium channel blockers. Duloxetine is a serotonin-noradrenaline reuptake inhibitor used in the treatment of diabetic neuropathic pain and fibromyalgia, as well as major depression. In this case, we aimed to discuss the tardive dyskinesia-like appearance of a patient using duloxetine due to fibromyalgia.

23 Article The relationship between serum leptin level and disease activity and inflammatory markers in fibromyalgia patients. 2018

Ataoglu, Safinaz / Ankarali, Handan / Samanci, Rumeysa / Ozsahin, Mustafa / Admis, Ozlem. ·Department of Physical Medicine and Rehabilitation, University of Duzce, Medical Faculty, Duzce, Turkey. · Department of Biostatistics and Medical Informatics, University of Istanbul Medeniyet, Medical Faculty, Istanbul, Turkey. · Department of Biochemistry, University of Duzce, Medical Faculty, Duzce, Turkey. ·North Clin Istanb · Pubmed #30374474.

ABSTRACT: OBJECTIVE: The aim of this study was to investigate whether there is a correlation between serum leptin level, disease activity and inflammation markers in patients with fibromyalgia syndrome (FMS). METHODS: A total of 48 patients with FMS diagnosed according to the 1990 American College of Rheumatology criteria were included in the study, as well as 36 healthy women as controls. The Visual Analogue Scale was used to gauge pain severity, the Fibromyalgia Impact Questionnaire was used to assess physical function, the 36-Item Short Form Health Survey was used to examine quality of life, and depression was measured with the Beck Depression Inventory. Blood samples were examined for erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP), high-sensitivity CRP level (hsCRP), the neutrophil-to-lymphocyte ratio (NLR), and the serum leptin level was determined using the enzyme-linked immunosorbent assay method. RESULTS: The serum leptin level in patients with FMS was significantly higher than in the healthy group. However, no significant relationship was found between leptin level and clinical and inflammatory parameters. In addition, there were no significant differences between the patients and the control group in measurements of ESR, CRP, hsCRP, or NLR. CONCLUSION: A higher serum leptin level in patients with FMS suggested that leptin may play role in the pathogenesis of FMS, yet there was no relationship between leptin and clinical and inflammatory parameters, suggesting that leptin is not an indicator of disease activity in FMS. Additional research should be performed with larger patient groups.

24 Article Demographic characteristics, clinical findings and functional status in patients with fibromyalgia syndrome. 2018

Demirbag, Birsel Canan / Bulut, Aliye. ·Faculty of Health Sciences, Department of Nursing Karadeniz Technical University, Trabzon. · Faculty of Health Sciences, Department of Nursing Bingol University, Bingol, Turkey. ·J Pak Med Assoc · Pubmed #30317299.

ABSTRACT: OBJECTIVE: To explore the demographic features, clinical findings and functional status in patients presenting with fibromyalgia syndrome. METHODS: The cross-sectional study was conducted between May 1 and August 1, 2017, and comprised fibromyalgia syndrome patients who were followed up at the Physical Medicine and Rehabilitation Polyclinic of Bingöl State Hospital, Bingöl, Turkey. Data collection was done using a predesigned questionnaire. It consisted of two parts. In the first part, patients were asked questions including their socio-demographic characteristics. In the second part, visual analogue scale and fibromyalgia impact questionnaire were applied for evaluating pain intensity and function. RESULTS: Of the 136 patients, 101(74.3%) had no sleeping pattern and 88(64.7%) were restricted in activities of daily living. Pain complaints were lasting for a mean period of 5.0±5.1 years and the diagnosis version was 3.8±3.2 years. The mean score of the fibromyalgia impact questionnaire was 53.3±15.3 and 125(91.9%) patients had a mild level. The mean score of visual analogue scale was 5.1±3.0 and 50(36.8%) patients had severe pain. Fibromyalgia impact questionnaire score of illiterate individuals was significantly higher than others (p<0.05), and the score of low-income individuals was higher than the others (p<0.05). Individuals with high income had the lowest score (p<0.05). CONCLUSIONS: Patients with fibromyalgia had a better course of illness when their education and socio-economic status were in good condition, and the complications of pain and illness were further reduced.

25 Article Frequency of audiological complaints in patients with fibromyalgia syndrome and its relationship with oxidative stress. 2018

Koca, T T / Seyithanoglu, M / Sagiroglu, S / Berk, E / Dagli, H. ·Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Turkey. · Department of Clinic Biochemistry, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Turkey. · Department of Otorhinolaryngology, Faculty of Medicine, Sütçü İmam University, Kahramanmaraş, Turkey. ·Niger J Clin Pract · Pubmed #30297558.

ABSTRACT: Aim: Central sensitization-related neuroaudiological symptoms are frequently seen in patients with fibromyalgia syndrome (FMS). This study aimed to evaluate the audiological signs and symptoms in patients with FMS and explore their relationship with oxidative stress markers. Methods: This prospective controlled cross-sectional study compared the serum myeloperoxidase, superoxide dismutase, glutathione peroxidase (GPx), nitric oxide (NO), and malondialdehyde (MDA) concentrations in 44 patients with FMS diagnosed according to the 2010 American College of Rheumatology criteria and 44 healthy volunteers. FMS severity was assessed using the visual analog scale and Fibromyalgia Impact Questionnaire. An audiological assessment including vocalizations, vertigo, balance problems, and hearing problems was done to all participants. Results: The two groups were of similar age (P = 0.24), gender (P = 0.40), and weight distribution (P = 0.6). Vertigo, tinnitus, hearing, and balance complaints (P = 0.01/P = 0.00/P = 0.00/P = 0.01) were significantly higher in the FMS group. All subunits and total scores of dizziness handicap inventory were significantly higher (P = 0.00/P = 0.00/P = 0.01/P = 0.01) in the FMS group. An antioxidant GPx and oxidant parameters such as NO and MDA were found to be significantly higher (P = 0.00/P = 0.01/P = 0.02). The hearing assessments at frequencies between 250 and 12,000 Hz showed a significant difference between the two groups (high hearing frequencies in the FMS group) in audiometry. No significant difference was found between the two groups in terms of the presence of stabilo-acoustic reflex, intraaural pressure, and compliance (P = 0.18/P = 0.33/P = 0.41) in tympanogram. Conclusions: Patients with FMS have high levels of oxidative stress markers (GPx, NO, and MDA), highly frequent audiological symptoms with high hearing frequencies in audiometry, independent of disease severity.

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