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Glaucoma: HELP
Articles by Maria Vittoria Cicinelli
Based on 4 articles published since 2008
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Between 2008 and 2019, Maria V. Cicinelli wrote the following 4 articles about Glaucoma.
 
+ Citations + Abstracts
1 Review Global causes of blindness and distance vision impairment 1990-2020: a systematic review and meta-analysis. 2017

Flaxman, Seth R / Bourne, Rupert R A / Resnikoff, Serge / Ackland, Peter / Braithwaite, Tasanee / Cicinelli, Maria V / Das, Aditi / Jonas, Jost B / Keeffe, Jill / Kempen, John H / Leasher, Janet / Limburg, Hans / Naidoo, Kovin / Pesudovs, Konrad / Silvester, Alex / Stevens, Gretchen A / Tahhan, Nina / Wong, Tien Y / Taylor, Hugh R / Anonymous15250923. ·Department of Mathematics and Data Science Institute, Imperial College London, London, UK. · Vision and Eye Research Unit, Anglia Ruskin University, Cambridge, UK. Electronic address: rb@rupertbourne.co.uk. · Brien Holden Vision Institute, Sydney, NSW, Australia; School of Optometry and Vision Science, University of New South Wales, Sydney, NSW, Australia. · International Agency for the Prevention of Blindness, London, UK. · Moorfields Eye Hospital NHS Foundation Trust, London, UK. · San Raffaele Scientific Institute, Milan, Italy. · York Hospital, York, UK. · Department of Ophthalmology, Universitätsmedizin, Mannheim, Germany; Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. · L V Prasad Eye Institute, Hyderabad, India. · Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Harvard Medical School, Boston, MA, USA; Discovery Eye Center, Addis Ababa, Ethiopia; MyungSung Christian Medical Center, Addis Ababa, Ethiopia. · Nova Southeastern University, Fort Lauderdale, FL, USA. · Health Information Services, Grootebroek, Netherlands. · Brien Holden Vision Institute, Sydney, NSW, Australia; African Vision Research Institute, University of Kwazulu-Natal, Glenwood, Durban, South Africa. · National Health and Medical Research Council Centre for Clinical Eye Research, Flinders University, Adelaide, SA, Australia. · SpaMedica Research Institute, Bolton, UK. · Department of Information, Evidence and Research, World Health Organization, Geneva, Switzerland. · Singapore Eye Research Institute, Duke-National University of Singapore Graduate Medical School, National University of Singapore, Singapore. · Melbourne School of Population and Global Health, University of Melbourne, Melbourne, VIC, Australia. ·Lancet Glob Health · Pubmed #29032195.

ABSTRACT: BACKGROUND: Contemporary data for causes of vision impairment and blindness form an important basis of recommendations in public health policies. Refreshment of the Global Vision Database with recently published data sources permitted modelling of cause of vision loss data from 1990 to 2015, further disaggregation by cause, and forecasts to 2020. METHODS: In this systematic review and meta-analysis, we analysed published and unpublished population-based data for the causes of vision impairment and blindness from 1980 to 2014. We identified population-based studies published before July 8, 2014, by searching online databases with no language restrictions (MEDLINE from Jan 1, 1946, and Embase from Jan 1, 1974, and the WHO Library Database). We fitted a series of regression models to estimate the proportion of moderate or severe vision impairment (defined as presenting visual acuity of <6/18 but ≥3/60 in the better eye) and blindness (presenting visual acuity of <3/60 in the better eye) by cause, age, region, and year. FINDINGS: We identified 288 studies of 3 983 541 participants contributing data from 98 countries. Among the global population with moderate or severe vision impairment in 2015 (216·6 million [80% uncertainty interval 98·5 million to 359·1 million]), the leading causes were uncorrected refractive error (116·3 million [49·4 million to 202·1 million]), cataract (52·6 million [18·2 million to 109·6 million]), age-related macular degeneration (8·4 million [0·9 million to 29·5 million]), glaucoma (4·0 million [0·6 million to 13·3 million]), and diabetic retinopathy (2·6 million [0·2 million to 9·9 million]). Among the global population who were blind in 2015 (36·0 million [12·9 million to 65·4 million]), the leading causes were cataract (12·6 million [3·4 million to 28·7 million]), uncorrected refractive error (7·4 million [2·4 million to 14·8 million]), and glaucoma (2·9 million [0·4 million to 9·9 million]). By 2020, among the global population with moderate or severe vision impairment (237·1 million [101·5 million to 399·0 million]), the number of people affected by uncorrected refractive error is anticipated to rise to 127·7 million (51·0 million to 225·3 million), by cataract to 57·1 million (17·9 million to 124·1 million), by age-related macular degeneration to 8·8 million (0·8 million to 32·1 million), by glaucoma to 4·5 million (0·5 million to 15·4 million), and by diabetic retinopathy to 3·2 million (0·2 million to 12·9 million). By 2020, among the global population who are blind (38·5 million [13·2 million to 70·9 million]), the number of patients blind because of cataract is anticipated to rise to 13·4 million (3·3 million to 31·6 million), because of uncorrected refractive error to 8·0 million (2·5 million to 16·3 million), and because of glaucoma to 3·2 million (0·4 million to 11·0 million). Cataract and uncorrected refractive error combined contributed to 55% of blindness and 77% of vision impairment in adults aged 50 years and older in 2015. World regions varied markedly in the causes of blindness and vision impairment in this age group, with a low prevalence of cataract (<22% for blindness and 14·1-15·9% for vision impairment) and a high prevalence of age-related macular degeneration (>14% of blindness) as causes in the high-income subregions. Blindness and vision impairment at all ages in 2015 due to diabetic retinopathy (odds ratio 2·52 [1·48-3·73]) and cataract (1·21 [1·17-1·25]) were more common among women than among men, whereas blindness and vision impairment due to glaucoma (0·71 [0·57-0·86]) and corneal opacity (0·54 [0·43-0·66]) were more common among men than among women, with no sex difference related to age-related macular degeneration (0·91 [0·70-1·14]). INTERPRETATION: The number of people affected by the common causes of vision loss has increased substantially as the population increases and ages. Preventable vision loss due to cataract (reversible with surgery) and refractive error (reversible with spectacle correction) continue to cause most cases of blindness and moderate or severe vision impairment in adults aged 50 years and older. A large scale-up of eye care provision to cope with the increasing numbers is needed to address avoidable vision loss. FUNDING: Brien Holden Vision Institute.

2 Article Comparison of methods to quantify macular and peripapillary vessel density in optical coherence tomography angiography. 2018

Rabiolo, Alessandro / Gelormini, Francesco / Sacconi, Riccardo / Cicinelli, Maria Vittoria / Triolo, Giacinto / Bettin, Paolo / Nouri-Mahdavi, Kouros / Bandello, Francesco / Querques, Giuseppe. ·Department of Ophthalmology, University Vita-Salute, IRCCS San Raffaele, Milan, Italy. · Stein Eye Institute, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, California, United States of America. · Eye Clinic, Department of Neurological and Movement Sciences, University of Verona, Verona, Italy. ·PLoS One · Pubmed #30335815.

ABSTRACT: PURPOSE: To compare macular and peripapillary vessel density values calculated on optical coherence tomography angiography (OCT-A) images with different algorithms, elaborate conversion formula, and compare the ability to discriminate healthy from affected eyes. METHODS: Cross-sectional study of healthy subjects, patients with diabetic retinopathy, and glaucoma patients (44 eyes in each group). Vessel density in the macular superficial capillary plexus (SCP), deep capillary plexus (DCP), and the peripapillary radial capillary plexus (RCP) were calculated with seven previously published algorithms. Systemic differences, diagnostic properties, reliability, and agreement of the methods were investigated. RESULTS: Healthy eyes exhibited higher vessel density values in all plexuses compared to diseased eyes regardless of the algorithm used (p<0.01). The estimated vessel densities were significantly different at all the plexuses (p<0.0001) as a function of method used. Inter-method reliability and agreement was mostly poor to moderate. A conversion formula was available for every method, except for the conversion between multilevel and fixed at the DCP. Substantial systemic, non-constant biases were evident between many algorithms. No algorithm outperformed the others for discrimination of patients from healthy subjects in all the retinal plexuses, but the best performing algorithm varied with the selected plexus. CONCLUSIONS: Absolute vessel density values calculated with different algorithms are not directly interchangeable. Differences between healthy and affected eyes could be appreciated with all methods with different discriminatory abilities as a function of the plexus analyzed. Longitudinal monitoring of vessel density should be performed with the same algorithm. Studies adopting vessel density as an outcome measure should not rely on external normative databases.

3 Article Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe in 2015: magnitude, temporal trends and projections. 2018

Bourne, Rupert R A / Jonas, Jost B / Bron, Alain M / Cicinelli, Maria Vittoria / Das, Aditi / Flaxman, Seth R / Friedman, David S / Keeffe, Jill E / Kempen, John H / Leasher, Janet / Limburg, Hans / Naidoo, Kovin / Pesudovs, Konrad / Peto, Tunde / Saadine, Jinan / Silvester, Alexander J / Tahhan, Nina / Taylor, Hugh R / Varma, Rohit / Wong, Tien Y / Resnikoff, Serge / Anonymous6461055. ·Vision & Eye Research Unit, Anglia Ruskin University, Cambridge, UK. · Department of Ophthalmology, Universitätsmedizin, Mannheim, Germany. · Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. · INRA, UMR1324 Centre des Sciences du Goût et de l'Alimentation, Dijon, France. · CNRS, UMR6265 Centre des Sciences du Goût et de l'Alimentation, Dijon, France. · Centre des Sciences du Goût et de l'Alimentation, Université Bourgogne Franche-Comté, Dijon, France. · Ophthalmology Department, Dijon University Hospital, Dijon, France. · San Raffaele Scientific Institute, Milan, Italy. · Health Education Yorkshire and the Humber, Leeds, UK. · Department of Mathematics and Data Science Institute, Imperial College London, London, UK. · Department of Statistics, University of Oxford, Oxford, UK. · Dana Center for Preventive Ophthalmology, Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA. · LV Prasad Eye Institute, Hyderabad, India. · Department of Ophthalmology, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA. · Discovery Eye Center, Addis Ababa, Ethiopia. · Myungsung Christian Medical Center and Medical School, Addis Ababa, Ethiopia. · Nova Southeastern University, Davie, Florida, USA. · Health Information Services, Grootebroek, The Netherlands. · African Vision Research Institute, University of Kwazulu-Natal, Brien Holden Vision Institute, Durban, South Africa. · NHMRC Centre for Clinical Eye Research, Flinders University, Adelaide, South Australia, Australia. · School of Medicine, Dentistry and Biomedical Sciences, Queen's University Belfast, Belfast, UK. · Centers for Disease Control and Prevention, Atlanta, Georgia, USA. · St Pauls Eye Unit, Royal Liverpool University Hospital, Liverpool, UK. · Brien Holden Vision Institute, Sydney, New South Wales, Australia. · School of Optometry and Vision Science, University of New South Wales, Sydney, New South Wales, Australia. · Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia. · Department of Ophthalmology, Keck School of Medicine of USC, Los Angeles, California, USA. · Singapore Eye Research Institute, Duke-NUS Graduate Medical School, National University of Singapore, Singapore. ·Br J Ophthalmol · Pubmed #29545417.

ABSTRACT: BACKGROUND: Within a surveillance of the prevalence and causes of vision impairment in high-income regions and Central/Eastern Europe, we update figures through 2015 and forecast expected values in 2020. METHODS: Based on a systematic review of medical literature, prevalence of blindness, moderate and severe vision impairment (MSVI), mild vision impairment and presbyopia was estimated for 1990, 2010, 2015, and 2020. RESULTS: Age-standardised prevalence of blindness and MSVI for all ages decreased from 1990 to 2015 from 0.26% (0.10-0.46) to 0.15% (0.06-0.26) and from 1.74% (0.76-2.94) to 1.27% (0.55-2.17), respectively. In 2015, the number of individuals affected by blindness, MSVI and mild vision impairment ranged from 70 000, 630 000 and 610 000, respectively, in Australasia to 980 000, 7.46 million and 7.25 million, respectively, in North America and 1.16 million, 9.61 million and 9.47 million, respectively, in Western Europe. In 2015, cataract was the most common cause for blindness, followed by age-related macular degeneration (AMD), glaucoma, uncorrected refractive error, diabetic retinopathy and cornea-related disorders, with declining burden from cataract and AMD over time. Uncorrected refractive error was the leading cause of MSVI. CONCLUSIONS: While continuing to advance control of cataract and AMD as the leading causes of blindness remains a high priority, overcoming barriers to uptake of refractive error services would address approximately half of the MSVI burden. New data on burden of presbyopia identify this entity as an important public health problem in this population. Additional research on better treatments, better implementation with existing tools and ongoing surveillance of the problem is needed.

4 Minor Subconjunctival sustained-release dexamethasone implant as an adjunct to trabeculectomy for primary open angle glaucoma. 2016

Furino, Claudio / Boscia, Francesco / Cicinelli, Maria Vittoria / Sborgia, Alessandra / Alessio, Giovanni. ·Department of Ophthalmology, University of Bari, Bari, Italy. ·Indian J Ophthalmol · Pubmed #27146944.

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