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Glaucoma: HELP
Articles by Yvonne Ou
Based on 10 articles published since 2010
(Why 10 articles?)
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Between 2010 and 2020, Yvonne Ou wrote the following 10 articles about Glaucoma.
 
+ Citations + Abstracts
1 Review Surgical Management of Pediatric Glaucoma. 2017

Chang, Ingrid / Caprioli, Joseph / Ou, Yvonne. · ·Dev Ophthalmol · Pubmed #28442696.

ABSTRACT: Pediatric glaucoma surgery is challenging because of the differences in anatomy from the adult, differences in the behavior of the tissues of a child's glaucomatous eye, the variety in causes of the disease, and difficulties with postoperative management. Goniotomy and trabeculotomy are the preferred initial treatments for primary congenital glaucoma. Trabeculectomy with adjunctive mitomycin C is more likely to succeed in older, phakic patients, but carries the long-term risk of bleb-associated endophthalmitis. Glaucoma drainage devices may be preferred in younger children and in patients with aphakic glaucoma, but these devices can cause tube-related complications. Lastly, cyclodestructive procedures are reserved for patients in whom filtering surgery has failed, given its more unpredictable effects and serious complications.

2 Review Who's lost first? Susceptibility of retinal ganglion cell types in experimental glaucoma. 2017

Della Santina, Luca / Ou, Yvonne. ·Department of Pharmacy, University of Pisa, Via Bonanno, 6, Pisa, 56126, Italy. Electronic address: luca.dellasantina@gmail.com. · Department of Ophthalmology, University of California, San Francisco, 10 Koret Way, San Francisco, CA, 94143, USA. Electronic address: yvonne.ou@ucsf.edu. ·Exp Eye Res · Pubmed #27319294.

ABSTRACT: The purpose of this article is to summarize our current knowledge about the susceptibility of specific retinal ganglion cell (RGC) types in experimental glaucoma, and to delineate the initial morphological and functional alterations that occur in response to intraocular pressure (IOP) elevation. There has been debate in the field as to whether RGCs with large somata and axons are more vulnerable, with definitive conclusions still in progress because of the wide diversity of RGC types. Indeed, it is now estimated that there are greater than 30 different RGC types, and while we do not yet understand the complete details, we discuss a growing body of work that supports the selective vulnerability hypothesis of specific RGC types in experimental glaucoma. Specifically, structural and functional degeneration of various RGC types have been examined across different rodent models of experimental glaucoma (acute vs. chronic) and different strains, and an emerging consensus is that OFF RGCs appear to be more vulnerable to IOP elevation compared to ON RGCs. Understanding the mechanisms by which this selective vulnerability manifests across different RGC types should lead to novel and improved strategies for neuroprotection and neuroregeneration in glaucoma.

3 Review Surgical management of pediatric glaucoma. 2012

Ou, Yvonne / Caprioli, Joseph. ·Glaucoma Division, Department of Ophthalmology, University of California, San Francisco, Calif, USA. giorgio.marchini@univr.it ·Dev Ophthalmol · Pubmed #22517182.

ABSTRACT: Pediatric glaucoma surgery is challenging because of the differences in anatomy from the adult, differences in the behavior of the tissues of a child's glaucomatous eye, the variety in causes of the disease, and difficulties with postoperative management. Goniotomy and trabeculotomy are the preferred initial treatments for primary congenital glaucoma. Trabeculectomy with adjunctive mitomycin C is more likely to succeed in older, phakic patients, but carries the long-term risk of bleb-associated endophthalmitis. Glaucoma drainage devices may be preferred in younger children and in patients with aphakic glaucoma, but these devices can cause tube-related complications. Lastly, cyclodestructive procedures are reserved for patients in whom filtering surgery has failed, given its more unpredictable effects and serious complications.

4 Article Biolistic Labeling of Retinal Ganglion Cells. 2018

Santina, Luca Della / Ou, Yvonne. ·Department of Ophthalmology, University of California, San Francisco, 10 Koret Way, San Francisco, CA, 94143, USA. luca.dellasantina@ucsf.edu. · Department of Ophthalmology, University of California, San Francisco, 10 Koret Way, San Francisco, CA, 94143, USA. ·Methods Mol Biol · Pubmed #29190026.

ABSTRACT: Labeling of cellular structures is of fundamental importance in the investigation of diseases of the central nervous system. Biolistic labeling of retinal ganglion cells (RGCs) allows visualization of dendritic and synaptic structures of RGCs in retinal explants from animal models of experimental glaucoma. This technique sparsely labels RGCs, and, due to the stochastic nature of the particle delivery, all RGC types can be potentially observed in the labeled tissue. Quantification of dendritic and synaptic properties permits examination of the specific alterations to RGC morphology at different stages of degeneration, such as dendritic shrinkage and excitatory synapse loss.

5 Article Selective Vulnerability of Specific Retinal Ganglion Cell Types and Synapses after Transient Ocular Hypertension. 2016

Ou, Yvonne / Jo, Rebecca E / Ullian, Erik M / Wong, Rachel O L / Della Santina, Luca. ·Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143, yvonne.ou@ucsf.edu luca.dellasantina@gmail.com. · Department of Ophthalmology, University of California, San Francisco, San Francisco, California 94143. · Department of Biological Structure, University of Washington, Seattle, Washington 98195, and. · Department of Biological Structure, University of Washington, Seattle, Washington 98195, and Department of Pharmacy, University of Pisa, Pisa, Italy 56126 yvonne.ou@ucsf.edu luca.dellasantina@gmail.com. ·J Neurosci · Pubmed #27581463.

ABSTRACT: SIGNIFICANCE STATEMENT: Conflicting reports regarding the selective vulnerability of specific retinal ganglion cell (RGC) types in glaucoma exist. We examine, for the first time, the effects of transient intraocular pressure elevation on the structure and function of various RGC types. Among the α-like RGCs studied, αOFF-transient RGCs are the most vulnerable to transient transient intraocular pressure elevation as measured by rates of cell death, morphologic alterations in dendrites and synapses, and physiological dysfunction. Specifically, we found that presynaptic ribbon density decreased to a greater degree in the OFF sublamina of the inner plexiform layer. Our results suggest selective vulnerability both of specific types of RGCs and of specific inner plexiform layer sublaminae, opening new avenues for identifying novel diagnostic and treatment targets in glaucoma.

6 Article Scleral intraocular pressure measurement in cadaver eyes pre- and postkeratoprosthesis implantation. 2014

Lin, Charles C / Chen, Aiyin / Jeng, Bennie H / Porco, Travis C / Ou, Yvonne / Han, Ying. ·Department of Ophthalmology, Stanford University, Stanford, California, United States. ·Invest Ophthalmol Vis Sci · Pubmed #24557348.

ABSTRACT: PURPOSE: We correlated scleral IOP to assigned IOP using pneumatonometry in cadaver eyes before and after Boston type I keratoprosthesis (KPro) implantation. METHODS: Corneal IOP and scleral IOP at the superonasal, superotemporal, inferotemporal, and inferonasal quadrants were measured using pneumatonometry in six cadaver eyes cannulated with an infusion line with assigned IOP held at 20, 30, 40, and 50 mm Hg. Measurements of scleral IOP at the same location were repeated after a KPro was implanted. Correlations between scleral IOP and assigned IOP were analyzed for the entire group of eyes, and for each individual eye before and after KPro. One eye was tested by another masked grader for interobserver variability. RESULTS: Scleral IOP measured higher than corneal IOP by a mean of 13.2 mm Hg. For group analysis, pre-KPro scleral IOP had a positive and linear correlation with assigned IOP in all quadrants (P < 0.00001), and this correlation was preserved after KPro implantation (P < 0.00001). There was strong interobserver agreement in all measurement sites (P < 0.001). In analyses of individual eyes, scleral IOP measured at the inferotemporal quadrant confirmed the strong linear association between scleral IOP and assigned IOP before and after KPro for all study eyes. A Bland-Altman plot showed that the difference in scleral IOP between pre-KPro and post-KPro eyes fell mostly within ± 5 mm Hg. CONCLUSIONS: Scleral IOP measured by pneumatonometry may be used to estimate IOP in cadaver eyes with and without keratoprosthesis. This may be a potential modality for assessing IOP for patients with corneal pathology or keratoprosthesis.

7 Article Glaucoma, Alzheimer disease and other dementia: a longitudinal analysis. 2012

Ou, Yvonne / Grossman, Daniel S / Lee, Paul P / Sloan, Frank A. ·Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA. ·Ophthalmic Epidemiol · Pubmed #22978529.

ABSTRACT: PURPOSE: To evaluate the risk of developing Alzheimer disease (AD) or other dementia in patients diagnosed with open-angle glaucoma (OAG) in a nationally representative longitudinal sample of elderly persons. METHODS: This retrospective cohort study (January 1, 1994-December 31, 2007) used Medicare 5% claims data. We identified beneficiaries aged 68+ years who had at least two claims with diagnoses of OAG and no Alzheimer or other dementia in 1994, using a 3-year look-back period between 1991 and 1993 (n = 63,235) and beneficiaries matched on age, sex, race, and Charlson index without a diagnosis of OAG throughout the observational period (n = 63,235), using propensity score matching. Using a Cox Proportional Hazards model, we analyzed time to AD diagnosis and time to AD or other dementia diagnosis. RESULTS: Elderly individuals diagnosed with OAG did not have an increased rate of AD and other dementia diagnosis compared to those without OAG during a 14-year follow-up period, even after controlling for relevant covariates present at baseline. CONCLUSIONS: Individuals aged 68+ years diagnosed with OAG have a decreased rate of AD or other dementia diagnosis compared to control patients without an OAG diagnosis. Although OAG and AD are both age-related neurodegenerative diseases, our findings do not support a positive association.

8 Article Development of a resident training module for systematic optic disc evaluation in glaucoma. 2012

Law, Simon K / Tamboli, Diana A / Ou, Yvonne / Giaconi, Joann A / Caprioli, Joseph. ·Jules Stein Eye Institute, University of California, Los Angeles, CA, USA. law@jsei.ucla.edu ·J Glaucoma · Pubmed #21602706.

ABSTRACT: PURPOSE: To determine the impact on ophthalmology residents of a training module to teach systematic optic disc (disc) evaluation. METHODS: A training module for disc evaluation was developed consisting of: (1) a computer-based evaluation course with 100 illustrative disc photographs featuring normal and glaucomatous discs; (2) 2 different disc photograph test sets to be completed before and after taking the course; and (3) a 1-page checklist emphasizing 8 areas of disc evaluation to guide the residents through the test sets. Each area required identification of 2 to 3 key features pertinent to glaucoma. Points were assigned to each correctly answered item on the checklist by ophthalmology residents of 2 training programs. Residents were also asked to evaluate the disc according to a glaucoma scale. Main outcome measures included precourse and postcourse checklist scores and disc glaucoma evaluation scores. RESULTS: Twenty-eight residents from 2 training programs completed the training module. Mean checklist scores improved significantly after taking the evaluation course across all residents and in residents who had 2 years of ophthalmology residency experience (P = 0.019, 0.017, respectively). Precourse disc glaucoma evaluation score increased 4% to 6% per year of ophthalmology residency training (P = 0.023, R = 0.1838). One program had a higher mean postcourse disc glaucoma evaluation score than another (P = 0.038). CONCLUSIONS: A systematic disc evaluation module for resident training may improve disc evaluation, provide an objective method to assess the resident's learning experience, monitor the progress and identify areas of weakness of training, and compare results among groups of residents across different residency programs.

9 Article A critical appraisal and comparison of the quality and recommendations of glaucoma clinical practice guidelines. 2011

Ou, Yvonne / Goldberg, Ivan / Migdal, Clive / Lee, Paul P. ·Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, USA. ·Ophthalmology · Pubmed #21507487.

ABSTRACT: PURPOSE: To appraise primary open-angle glaucoma (POAG) practice guidelines critically and to compare these guidelines' major recommendations. DESIGN: Evaluation of clinical practice guidelines and their development process. PARTICIPANTS: Glaucoma fellowship-trained ophthalmologists. METHODS: The POAG clinical practice guidelines published by the American Academy of Ophthalmology (AAO), European Glaucoma Society (EGS), and South East Asia Glaucoma Interest Group (SEAGIG) were evaluated by independent reviewers using the Appraisal of Guidelines for Research and Evaluation (AGREE) instrument. MAIN OUTCOME MEASURES: Domain scores using the AGREE instrument. RESULTS: Critical appraisal using the AGREE instrument demonstrated that the AAO guidelines scored favorably (>60%) in the domains of scope and purpose, rigor of development, and clarity and presentation, while scoring unfavorably (<60%) in the domains of stakeholder involvement, applicability, and editorial independence. The Terminology and Guidelines for Glaucoma and the Asia Pacific Glaucoma Guidelines respectively developed by EGS and SEAGIG scored favorably in the domains of scope and purpose and clarity and presentation, but scored unfavorably in the domains of stakeholder involvement, applicability, and editorial independence. The major recommendations regarding diagnosis and management of POAG were similar among the 3 guidelines, although the level of detail varied considerably. CONCLUSIONS: Although the clinical practice guidelines from the AAO, SEAGIG, and EGS have contributed to developing evidence-based guidelines for glaucoma management, there is variability in the quality of the guideline development process and how it is reported as evaluated by a standardized instrument. The adoption of common standards in developing clinical practice guidelines in ophthalmology should improve their consistency and quality. FINANCIAL DISCLOSURE(S): Proprietary or commercial disclosure may be found after the references.

10 Unspecified Neurotrophic keratitis after micropulse transscleral diode laser cyclophotocoagulation. 2019

Perez, Claudio I / Han, Ying / Rose-Nussbaumer, Jennifer / Ou, Yvonne / Hsia, Yen C. ·Department of Ophthalmology, University of California, San Francisco, CA, USA. · Fundación Oftalmológica los Andes, Universidad de los Andes, Santiago, Chile. · Francis I Proctor Foundation, University of California, San Francisco, CA, USA. ·Am J Ophthalmol Case Rep · Pubmed #31193794.

ABSTRACT: Purpose: To report two cases of neurotrophic keratitis (NK) after micropulse transscleral cyclophotocoagulation (MP-TCP). Observations: Two patients with predisposing factors for decreased corneal sensation developed NK 1 month after MP-TCP. Both patients did not heal with initial treatment with topical antibiotic and preservative free artificial tears. One patient required use of a bandage contact lens and the other patient required tarsorrhaphy. Both eyes experienced recurrence of NK. Conclusions and importance: NK can be triggered after MP-TCP in patients with underlying predisposing factors for decreased corneal sensation. This uncommon but vision-threatening complication should be discussed preoperatively with high-risk patients as a possible adverse event after MP-TCP and followed closely postoperatively.