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Glaucoma: HELP
Articles by Ning Li Wang
Based on 154 articles published since 2010
(Why 154 articles?)
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Between 2010 and 2020, N. L. Wang wrote the following 154 articles about Glaucoma.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7
1 Editorial [Emphasizing the technological specification of glaucoma examination to promote mutual recognition to the results]. 2014

Wang, Ningli. ·Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China. Email: wningli@vip.163.com. ·Zhonghua Yan Ke Za Zhi · Pubmed #25052798.

ABSTRACT: It is very important for us to establish the technological specifications in medical field. Many problems will appear if we neglect them, which include difficulty in approving the results of examination with each other, waste of medical resources and increase of patients' time and expense, lack of guarantee for medical quality and safety and insupportable for further study with collecting medical data, etc. Although many technical operations were included in glaucoma field, unified technical specification was still deficiency in our country, which will have some certain influence on the clinical and research work. Only increasing the understanding of importance of technological specifications and establishing the applications of glaucoma's technical specifications, our whole level of glaucoma diagnosis and treatment will be raised in the whole country.

2 Editorial [Emphasis on promotion of the adaptive technology is the sky point of improving of treatment and prevention level of glaucoma]. 2013

Wang, Ning-li. ·Beijing Tongren Eye Center,Beijing Tongren Hospital, Capital Medical University, Beijing institute of Ophthalmology, Beijing Ophthalmology & Visual Science Key Lab., Beijing 100730, China. Email: wningli@vip.163.com. ·Zhonghua Yan Ke Za Zhi · Pubmed #24512993.

ABSTRACT: Promoting the control of primary angle-closure glaucoma (PACG) and primary open angle glaucoma (POAG) is most important prevention program of blindness in China. PACG has been incorporated into the prevention program of blindness in China based on the population-based screening studies. However, the clinical screening should be strengthened in POAG. The creation of a series of appropriate technologies suitable for glaucoma prevention and management has been achieved in China, especially for PACG. The technologies have been evaluated in the pilot areas and obtained very good results in China. It is recommended to develop new technology suitable for glaucoma management using the following workflow: research, development, and evaluation by large scale hospitals, and then clinical trial in the pilot areas. After a cost-benefit analysis is made, the new technology can be promoted and applied in clinical practice nationwide. We propose to gradually formed a strategical mode of "screening in township hospitals, intervention in county hospitals, and technical support and tackling in provincial hospitals" in order to improve the level of prevention and treatment of glaucoma and reduce the blindness incidence rate caused by glaucoma.

3 Review Progression on canaloplasty for primary open angle glaucoma. 2019

Zhang, Jun / Wang, Ning-Li. ·Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China. · Dalian Aier Eye Hospital, Dalian 116031, Liaoning Province, China. ·Int J Ophthalmol · Pubmed #31637200.

ABSTRACT: As a non-penetrating glaucoma surgery (NPGS), canaloplasty aims to reconstruct the physiological outflow of aqueous humor by dilating the Schlemm's canal. Ab interno canaloplasty (ABiC), which can reconstruct the natural outflow pathways of aqueous humor in mild-to-moderate primary open angle glaucoma (POAG) patients, is a new minimally invasive glaucoma surgery (MIGS) procedure improving from traditional canaloplasty. Canaloplasty can reduce intraocular pressure (IOP) with high efficiency and security. There are no complications such as scar formation and encapsulation for this no-bleb canaloplasty.

4 Review The genetics of angle closure glaucoma. 2019

Wang, Jin / Yusufu, Mayinuer / Khor, Chiea Chuen / Aung, Tin / Wang, Ningli. ·Beijing Tongren Hospital, Capital Medical University, Beijing, China. · Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, China. · Singapore Eye Research Institute, Singapore; Genome Institute of Singapore, Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. · Singapore Eye Research Institute, Singapore; Singapore National Eye Center, Singapore, Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. · Beijing Tongren Hospital, Capital Medical University, Beijing, China; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Key Laboratory of Ophthalmology and Visual Sciences, China. Electronic address: wningli@vip.163.com. ·Exp Eye Res · Pubmed #31634478.

ABSTRACT: Glaucoma, the leading cause of irreversible blindness worldwide, can be divided into two major types: primary open angle glaucoma (POAG) and primary angle closure glaucoma (PACG). PACG could lead to severe vision loss and has a high prevalence among Asian populations. The worldwide population affected by PACG is estimated to exceed 20 million by 2020. Recent studies have shown that there are at least eight genetic loci significantly associated with risk of PACG, possibly contributing to the phenotype by interacting with environmental factors. This review presents the progress that has been achieved in the genetics of PACG and its future perspectives. This article should be considered as a memorial article to honor Dr. R. Rand Allingham's remarkable contribution to genetic association studies in glaucoma. We are deeply saddened by the loss of Dr. Allingham, not only a huge loss for ophthalmology, but also loss of a dear friend. Looking back to his extraordinary career, Dr. Allingham devoted his whole life and passion into establishing the genetic basis of different forms of glaucoma such as open angle, angle closure, and exfoliation glaucoma. He had a special interest in analyses of populations from African ancestry, which greatly boosted the understanding of glaucoma genetics.

5 Review [Review of studies on the application of biomechanical factors in the evaluation of glaucoma]. 2019

Song, Hongfang / Li, Qi / Wang, Ningli / Wang, Wenjia / Long, Xiaoxue / Liu, Zhicheng. ·Beijing Key Laboratory of Fundamental Research on Biomechanics in Clinical Application, Beijing 100069, P.R.China;School of Biomedical Engineering, Capital Medical University, Beijing 100069, P.R.China. · Beijing Tongren Hospital, Capital Medical University, Beijing 100005, P.R.China. ·Sheng Wu Yi Xue Gong Cheng Xue Za Zhi · Pubmed #31016950.

ABSTRACT: There are so many biomechanical risk factors related with glaucoma and their relationship is much complex. This paper reviewed the state-of-the-art research works on glaucoma related mechanical effects. With regards to the development perspectives of studies on glaucoma biomechanics, a completely novel biomechanical evaluation factor -- Fractional Flow Reserve (FPR) for glaucoma was proposed, and developing clinical application oriented glaucoma risk assessment algorithm and application system by using the new techniques such as artificial intelligence and machine learning were suggested.

6 Review Mechanism of the reconstruction of aqueous outflow drainage. 2018

Xin, Chen / Tian, Ning / Li, Meng / Wang, Huaizhou / Wang, Ningli. ·Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China. · Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, 100005, China. · Department of ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. · Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China. wningli@vip.163.com. · Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, 100005, China. wningli@vip.163.com. ·Sci China Life Sci · Pubmed #29282607.

ABSTRACT: Glaucoma is the leading cause of irreversible blindness worldwide. The reconstruction of aqueous outflow drainage (RAOD) has recently been proposed to aid in restoring aqueous outflow drainage in primary open-angle glaucoma. However, the mechanism of RAOD remains to be fully understood. Based on literature review and research studies, the potential mechanisms of RAOD are the following: (i) Circumferential dilation of the Schlemm's canal (SC) and surrounding collector channels. (ii) Instant formation of microcracks through RAOD procedures. (iii) Formation of more pores, and local detachment between the SC endothelium (SCE) and basement membrane. (iv) Activation of stem cells by constant mechanical stress caused by the tensional suture placed at the anterior part of the SC. (v) Reversal of trabecular meshwork (TM) herniation. (vi) Mobilization of the reserve of the aqueous drainage. (vii) Change of SCE phenotype. (viii) Mechanosensing and mechanotransducing of TM.

7 Review Why does acute primary angle closure happen? Potential risk factors for acute primary angle closure. 2017

Zhang, Xiulan / Liu, Yaoming / Wang, Wei / Chen, Shida / Li, Fei / Huang, Wenbin / Aung, Tin / Wang, Ningli. ·Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China. Electronic address: zhangxl2@mail.sysu.edu.cn. · Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China. · Singapore Eye Research Institute and Singapore National Eye Centre, Singapore; Department of Ophthalmology, National University of Singapore, Singapore. · Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. ·Surv Ophthalmol · Pubmed #28428109.

ABSTRACT: Acute primary angle closure is an ocular emergency and requires immediate management to avoid blindness. Narrow anterior chamber angle, advanced age, female gender, and Asian ethnic background are considered risk factors for acute primary angle closure. The predictive power of these factors is, however, relatively poor, and many questions remain unanswered because acute primary angle closure eventually develops in only a relatively small proportion of anatomically predisposed eyes. We summarize the potential roles of various factors in the pathogenesis of acute primary angle closure.

8 Review [Diagnosis and treatment of ocular hypertension]. 2016

Sun, Y Y / Chen, W W / Wang, N L. ·Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital of Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing 100730, China. ·Zhonghua Yan Ke Za Zhi · Pubmed #27531115.

ABSTRACT: Ocular hypertension is popular among people, with a prevalence of 3% to 10% in those older than 40 years old. Without proper intervention, over 10% of the patients with ocular hypertension would develop glaucoma in the following 5 to 10 years. Glaucoma has become one of the leading causes of blindness all over the world, which makes it essential for us to pay enough attention to the prevention and treatment of ocular hypertension. However, it is not cost-effective to treat all the patients with ocular hypertension. Certain side effects may also be caused with long-term medical treatment. Therefore, it is of great importance for ophthalmologists to identify the right time and use appropriate therapeutic methods. To introduce the knowledge of ocular hypertension, the definition, epidemiology, diagnosis, risk factors and treatment of ocular hypertension are reviewed in this article. (Chin J Ophthalmol, 2016, 52: 542-546).

9 Review Translamina Cribrosa Pressure Difference as Potential Element in the Pathogenesis of Glaucomatous Optic Neuropathy. 2016

Jonas, Jost B / Wang, Ningli / Yang, Diya. ·From the *Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University, Seegartenklinik Heidelberg, Germany; †Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory; and ‡Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. ·Asia Pac J Ophthalmol (Phila) · Pubmed #26713405.

ABSTRACT: The main proven risk factor for glaucomatous optic neuropathy (GON) is an intraocular pressure (IOP) higher than the pressure sensibility of the optic nerve head allows. Fulfilling Koch postulates, numerous studies have shown that the presence of high IOP leads to GON, that lowering IOP stops the progression of GON, and that a re-increase in IOP again causes the progression of GON. There are, however, many patients with glaucoma who have statistically normal or low IOP, and despite low IOP values, they develop progressing GON. These observations led to findings that IOP is only 1 of 2 determinants of the translamina cribrosa pressure difference (TLCPD), which is the main pressure-related parameter for the physiology and pathophysiology of the optic nerve head. The second parameter influencing TLCPD is orbital cerebrospinal fluid pressure (CSFP) as the counter pressure against IOP across the lamina cribrosa. Recent experimental and clinical studies have suggested that a low CSFP could be associated with GON in normal-pressure glaucoma. These investigations included studies with an experimental long-term reduction in CSFP in monkeys, population-based studies, and clinical retrospective and prospective investigations on patients with normal-pressure glaucoma. Besides TLCPD, other ocular parameters influenced by CSFP may be choroidal thickness, retinal vein pressure and diameter, occurrence of retinal vein occlusions, and occurrence and severity of diabetic retinopathy.

10 Review Choroidal physiology and primary angle closure disease. 2015

Zhang, Xiulan / Wang, Wei / Aung, Tin / Jonas, Jost B / Wang, Ningli. ·Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China. Electronic address: zhangxl2@mail.sysu.edu.cn. · Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China. · Glaucoma Service, Singapore National Eye Centre, Singapore. · Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Seegartenklinik, Heidelberg, Germany. · Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China. ·Surv Ophthalmol · Pubmed #26164737.

ABSTRACT: Primary angle closure disease (PACD), prevalent in Asian countries, is generally associated with a shallower anterior chamber, a shorter axial length, thicker lens, hyperopia, and female sex. Other physiologic factors, however, may be important, especially with regard to triggering acute primary angle closure. Thickening of the choroid has been demonstrated in untreated and treated, acute and chronic PACD eyes. Recently, there has been growing interest in studying the role of the choroid in the pathophysiology of PACD. The emergence of new imaging technology such as the enhanced depth imaging mode of spectral-domain optical coherence tomography and swept-source optical coherence tomography has contributed to understanding PACD pathologies. We summarize the functions of the choroid and choroidal changes in the pathogenesis of PACD, and discuss potential future developments.

11 Review Facts and myths of cerebrospinal fluid pressure for the physiology of the eye. 2015

Jonas, Jost B / Wang, Ningli / Yang, Diya / Ritch, Robert / Panda-Jonas, Songhomitra. ·Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Seegartenklinik, Heidelberg, Germany; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, China. · Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, China; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. Electronic address: wningli@vip.163.com. · Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. · Einhorn Clinical Research Center, New York Ear Eye and Ear Infirmary of Mt. Sinai, New York, NY, USA. · Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Seegartenklinik, Heidelberg, Germany. ·Prog Retin Eye Res · Pubmed #25619727.

ABSTRACT: The orbital cerebrospinal fluid pressure (CSFP) represents the true counter-pressure against the intraocular pressure (IOP) across the lamina cribrosa and is, therefore, one of the two determinants of the trans-lamina cribrosa pressure difference (TLPD). From this anatomic point of view, an elevated TLPD could be due to elevated IOP or abnormally low orbital CSFP. Both experimental and clinical studies have suggested that a low CSFP could be associated with glaucomatous optic neuropathy in normal-pressure glaucoma. These included monkey studies with an experimental long-term reduction in CSFP, and clinical retrospective and prospective studies on patients with normal-pressure glaucoma. Since the choroidal blood drains via the vortex veins through the superior ophthalmic vein into the intracranial cavernous sinus, anatomy suggests that the CSFP could influence choroidal thickness. A population-based study revealed that thicker subfoveal choroidal thickness was associated with higher CSFP. Since the central retinal vein passes through the orbital CSF space, anatomy suggests that the retinal venous pressure should be at least as high as the orbital CSFP. Other experimental, clinical or population-based studies suggested an association between higher CSFP and higher retinal venous pressure and wider retinal veins. Consequently, a higher estimated CSFP was associated with arterial hypertensive retinopathy (with respect to the dilated retinal vein diameter and higher arterial-to-venous diameter) and with the prevalence, severity and incidence of diabetic retinopathy. Physiologically, CSFP was related with higher IOP. The influence of the CSFP on the episcleral venous pressure and/or a regulation of both CSFP and IOP by a center in the dorsomedial/perifornical hypothalamus may be responsible for this. In summary, the CSFP may be an overlooked parameter in ocular physiology and pathology. Abnormal changes in the CSFP, in particular in relationship to the IOP, may have pathophysiologic importance.

12 Review Initial Treatment for Primary Angle-Closure Glaucoma in China. 2015

Liang, Yuan Bo / Wang, Ning Li / Rong, Shi Song / Thomas, Ravi. ·*The Affiliated Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang Province †Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong ‡Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing, China §Queensland Eye Institute, University of Queensland, Qld, Australia. ·J Glaucoma · Pubmed #24786102.

ABSTRACT: China has a large burden of primary angle-closure glaucoma (PACG) and the approach to treatment is different from that in most parts of the world. In China, trabeculectomy is a mainstay of initial treatment for PACG and laser peripheral iridotomy is reserved for PAC and PACG with peripheral angle synechiae ≤180 degrees. The greater reduction of and more stable IOP, lower frequency of acute angle closure, decreased progression of peripheral anterior synechia and glaucoma, and the reduction of ocular complications associated with long-term use of glaucoma medications support the use of initial trabeculectomy in PACG without significant lens opacities. Further study is required to determine the indications and effectiveness of initial trabeculectomy for PACG in a developing country setting.

13 Review [Research progress of the side effect of the prostaglandin drugs]. 2013

Liu, Xu-yang / Tang, Li / Peng, Yu-hao / Chen, Xiao-ming / Wang, Ning-li. · ·Zhonghua Yan Ke Za Zhi · Pubmed #24555212.

ABSTRACT: Glaucoma is one of the leading causes of blindness , second to cataract. Lowering intraocular pressure is the most effective therapeutic means for this disease, with prostaglandin analogs as the first-line medication. These drugs are efficacious and safe, with well-tolerated local adverse effects. They are also generally regarded to have almost no systemic untoward effect. Nonetheless, with the continuous rise in their popularity, systemic adverse effects caused by topical ocular use of prostaglandins have attracted increasing attention. These adverse effects include digestive, respiratory, and cardiovascular systems, as well as skin and hair. Although the incidence of these adverse effects is low, physicians need to be aware of their occurrence. Research progress of the prostacyclin class lOP-lowering medication side effects are reviewed.

14 Review Cerebrospinal fluid pressure and glaucoma. 2013

Jonas, Jost B / Wang, Ningli. ·Department of Ophthalmology, Medical Faculty Mannheim, University of Heidelberg, Germany. · Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University; Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. ·J Ophthalmic Vis Res · Pubmed #24349669.

ABSTRACT: Eyes with normal-pressure glaucoma and those with high-pressure glaucoma can show a similar optic nerve head appearance, while eyes with vascular optic neuropathies show a markedly different optic disc appearance. Factors in addition to intraocular pressure (IOP) may thus play a role in the pathogenesis of glaucomatous optic neuropathy. Clinical and experimental studies showed that (1) physiologic associations between cerebrospinal fluid (CSF) pressure, systemic arterial blood pressure, IOP and body mass index exist; (2) a low CSF pressure was associated with the development of glaucomatous optic nerve damage in cats; (3) patients with normal (intraocular) pressure glaucoma had significantly lower CSF pressure and a higher trans lamina cribrosa pressure difference when compared to normal subjects; and (4) patients with normal- pressure glaucoma as compared with patients with high-pressure glaucoma have a significantly narrower orbital CSF space. A shallow orbital CSF space has been shown to be associated with a low CSF pressure. Due to anatomic reasons, the orbital CSF pressure and the optic nerve tissue pressure (and not the atmospheric pressure) form the retro-laminar counter-pressure against the IOP and are thus part of the trans-lamina cribrosa pressure difference and gradient. Assuming that an elevated trans-lamina cribrosa pressure difference and a steeper trans-lamina cribrosa pressure gradient are important for glaucomatous optic nerve damage, a low orbital CSF pressure would therefore play a role in the pathogenesis of normal-(intraocular) pressure glaucoma. Due to the association between CSF pressure and blood pressure, a low blood pressure could be indirectly involved.

15 Review [Research progress in intraocular pressure monitoring of glaucoma]. 2013

Hao, Jie / Zhen, Yi / Ma, Jian-min / Wang, Ning-li. ·Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. · Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. Email: wningli@vip.163.com. ·Zhonghua Yan Ke Za Zhi · Pubmed #24330937.

ABSTRACT: Elevation of intraocular pressure (IOP) is a major risk factor for the development and the progression in glaucoma optic nerve damage. The reduction of IOP remains mainstream strategy of glaucoma therapy. A large fluctuation of IOP in the circadian rhythm may play a role in the optic nerve damage in glaucoma progression. IOP monitoring provides important information of IOP mean, peak and fluctuation to assist the diagnosis and treatment of glaucoma. With the development of technology, the commonly used methods of IOP monitoring including IOP measurement for diurnal, 24 hours, and habitual body position have evolved to continuous IOP-monitoring using novel device. The influencing factors including tonometer, body position and the light have been taken into account for the reliability of IOP measurement. In this review, we summarized the recent progress in IOP monitoring and the factors affecting the IOP measurements and discussed immense opportunity of IOP-monitoring to better diagnose and to treat for glaucoma.

16 Review Intracranial pressure and glaucoma. 2013

Jonas, Jost B / Yang, Diya / Wang, Ningli. ·Department of Ophthalmology, Medical Faculty Mannheim-Heidelberg, Mannheim, Germany. ·J Glaucoma · Pubmed #23733115.

ABSTRACT: Eyes with normal-tension and high-tension glaucoma can have a similar optic nerve head appearance, which differs markedly from the optic disc appearance in vascular optic neuropathies. Factors in addition to intraocular pressure (IOP) may play a role in the pathogenesis of glaucomatous optic neuropathy. Clinical and experimental studies have shown (1) physiologic associations between cerebrospinal fluid pressure (CSFP), systemic arterial blood pressure, IOP, and body mass index; (2) that a low CSFP was associated with the development of glaucomatous optic nerve damage in cats; and (3) that patients with normal-tension glaucoma had significantly lower CSFP and a higher trans-lamina cribrosa pressure difference when compared to normal subjects. Due to anatomic reasons, the orbital CSFP and the optic nerve tissue pressure (and not the atmospheric pressure) form the retro-laminar counter-pressure against the IOP and are thus part of the trans-lamina cribrosa pressure difference and gradient. Assuming that an elevated trans-lamina cribrosa pressure difference and a steeper trans-lamina cribrosa pressure gradient are important for glaucomatous optic nerve damage, a low orbital CSFP would therefore play a role in the pathogenesis of normal-tension glaucoma. Due to the association between CSFP and blood pressure, a low blood pressure would also be indirectly involved.

17 Review Low cerebrospinal fluid pressure in the pathogenesis of primary open-angle glaucoma: epiphenomenon or causal relationship? The Beijing Intracranial and Intraocular Pressure (iCOP) study. 2013

Wang, Ningli / Yang, Diya / Jonas, Jost B. ·Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing, China. ·J Glaucoma · Pubmed #23733114.

ABSTRACT: Previous experimental and clinical investigations have suggested that some patients with primary open-angle glaucoma may have an abnormally low orbital cerebrospinal fluid pressure (CSFP). A meta-analysis of available clinical data showed a marked overlap in lumbar CSFP measurements between patients with normal-tension glaucoma and healthy subjects, so that the question arises as to which additional factors play a role in the pathogenesis of glaucomatous optic neuropathy.

18 Review [Physical exercise and intraocular pressure]. 2011

Liang, Yuan-bo / Wu, Yue / Li, Si-zhen / Sun, Lan-ping / Wang, Ning-li. ·Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. yuanboliang@gmail.com ·Zhonghua Yan Ke Za Zhi · Pubmed #22177134.

ABSTRACT: In the 1960s, it had been observed that physical exercises could reduce the intraocular pressure (IOP) in patients with glaucoma. However, the effect of IOP reduction varied with exercise type and intensity, as well as the duration after exercise. Difference of lowering the IOP in glaucoma patients and healthy people were also observed. The mechanisms of reducing the IOP by exercise were very complicated and believed to be associated with the lower concentration of norepinephrine, the rising of colloid osmotic pressure, the co-action of nitric oxide and endothelin after exercise, and also related to the gene polymorphism of β2-adrenergic receptor. Physical exercise, such as jogging, walking and bicycle riding, could be suggested as a complimentary therapy in addition to the pharmaceutical and surgical therapies available for glaucoma patients, even though the mechanism for lowering IOP is not clear enough.

19 Clinical Trial One-year interim comparison of canaloplasty in primary open-angle glaucoma following failed filtering surgery with primary canaloplasty. 2016

Xin, Chen / Chen, Xiaoya / Shi, Yan / Li, Meng / Wang, Huaizhou / Wang, Ningli. ·Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. · Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. · Department of Ophthalmology, Xuzhou 1st Hospital, Jiangsu, China. ·Br J Ophthalmol · Pubmed #27060163.

ABSTRACT: BACKGROUND/AIMS: This study was to explore the 1-year interim efficacy and safety of canaloplasty for primary open-angle glaucoma (POAG) with failed glaucoma filtration surgery (GFS) but an intact Schlemm's canal (SC). METHODS: This was a single-surgeon prospective clinical study. Patients with POAG scheduled for canaloplasty were included and divided into two groups (with or without failed GFS). The status of SC was determined by gonioscopy and ultrasound biomicroscopy. Primary outcome measures included intraocular pressure (IOP) and glaucoma medication use at various follow-up points. The secondary outcome measure was the rate of surgical success. RESULTS: Thirty-seven eyes were enrolled in group 1 (no GFS) and 23 eyes were enrolled in group 2 (failed GFS). The mean IOP (16.0±1.6 vs 16.2±1.6 mm Hg) and the number of medications (0.3±0.8 vs 0.3±0.6) at 18 months after canaloplasty were not significantly different between the two groups. There was no significant difference in complete success rate (criteria A: 52.2% vs 59.5%, p=0.587; criteria B: 39.1% vs 48.6%, p=0.343), as well as the qualified success rate (criteria A: 86.5% vs 82.6%, p=0.668; criteria B: 78.4% vs 69.6%, p=0.445). In group 2, the age, sex, number of previous surgeries, time span between operations were not significantly associated with surgery failure (p=0.199, 0.747, 0.977 and 0.615). Hyphaema was the most common postoperative complications. CONCLUSIONS: Canaloplasty is an effective and safe option for POAG with failed GFS but an intact SC. TRIAL REGISTRATION NUMBER: ChiCTR-ICR-15005788, Results.

20 Clinical Trial Intraocular pressure lowering efficacy and safety of travoprost 0.004% as a replacement therapy in patients with open angle glaucoma or ocular hypertension. 2010

Ge, Jian / Sun, Xing-huai / Wang, Ning-li / Zhao, Jia-liang / Wu, Ling-ling / Chen, Xiao-ming / Wang, Zhi-xin / Li, Benny. ·Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, Guangdong 510060, China. gejian@mail.sysu.edu.cn ·Chin Med J (Engl) · Pubmed #20819599.

ABSTRACT: BACKGROUND: Travoprost has been widely used for the treatment of patients with open-angle glaucoma (OAG) or ocular hypertension (OH). The aim of this study was to evaluate the intraocular pressure (IOP) lowering efficacy of travoprost 0.004% monotherapy in patients previously treated with other topical hypotensive medications, and in previously untreated patients. METHODS: This open-label, 12-week study in 1651 adult patients with ocular hypertension or open-angle glaucoma who were untreated or required a change in therapy (due to either inadequate efficacy or safety issues) as judged by the investigator was conducted at 6 sites in China. Previously treated patients were instructed to discontinue their prior medications at the first visit. All the patients were dosed with travoprost 0.004% once-daily at 8 p.m. in both eyes for 12 weeks. Efficacy and safety evaluations were conducted at week 4 and 12. IOP measurements were performed at the same time of day at the follow-up visits. RESULTS: For patients transitioned to travoprost, mean IOP reductions from baseline in untreated and treated patients with different prior medications at week 12 were: latanoprost, (4.3 +/- 4.6) mmHg; beta-blocker, (6.3 +/- 4.0) mmHg; alpha-agonist, (7.5 +/- 4.3) mmHg; topical carbonic anhydrase inhibitors, (8.0 +/- 4.9) mmHg. All mean IOP changes from baseline were statistically significant (P < 0.001). No treatment-related serious adverse events were reported in this study. CONCLUSIONS: In patients treated with other hypotensive medications or untreated, the IOP reduction with travoprost was significant. The results of this study demonstrated the potential benefit of using travoprost as a replacement therapy in order to ensure adequate IOP control. Travoprost administered once daily was safe and well tolerated in patients with glaucoma or ocular hypertension.

21 Article Altered information flow and microstructure abnormalities of visual cortex in normal-tension glaucoma : evidences from rest-state fMRI and DKI. 2020

Li, Ting / Qu, Xiaoxia / Chen, Weiwei / Wang, Qian / Wang, Huaizhou / Wang, Ying / Huang, Caiyun / Zhang, Xun / Wang, Ningli / Xian, Junfang. ·Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. · Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, China. · Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, China. Electronic address: wningli@vip.163.com. · Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address: cjr.xianjunfang@vip.163.com. ·Brain Res · Pubmed #32389589.

ABSTRACT: Normal tension glaucoma (NTG) is a neurodegenerative disease involves multiple brain areas, but the mechanism remains unclear. The aim of this study is to investigate the correlation between structural injury and functional reorganization in the brain of NTG, using resting-state functional MRI and diffusion kurtosis imaging (DKI) data acquired for 26 NTG patients and 24 control subjects. Granger causality analysis (GCA) was used to calculate the effective connectivity (EC) between visual cortices and the whole brain to reflect the information flow. The fractional anisotropy (FA), mean kurtosis (MK), axial kurtosis (AK), and radial kurtosis (RK) derived from DKI of visual cortices were extracted to evaluate structural injury. Microstructural abnormalities were detected in bilateral BA17, BA18, and BA19. NTG patients showed significantly decreased EC from BA17 to higher visual cortices and increase EC from higher visual cortices to BA17. The EC from BA17 to posterior cingulate cortex (PCC) and from PCC to BA17 both significantly increased, while the EC from right BA18 and BA19 to PCC significantly decreased. Decreased EC between somatosensory cortex and BA17, as well as the decreased ECs between supramarginal gyrus (SMA) and BA17/BA19 were detected. Several abnormal ECs were significantly correlated with microstructural injuries of BA17 and BA18. In conclusion, NTG causes reorganization of information flows among visual cortices and other brain areas, which is consistent with brain microstructural injury.

22 Article Comparison of the Intraocular Pressure-Lowering Efficacy and Safety of the Brinzolamide/Brimonidine Fixed-Dose Combination versus Concomitant Use of Brinzolamide and Brimonidine for Management of Open-Angle Glaucoma or Ocular Hypertension. 2020

Wang, Ningli / Lu, Da-Wen / Pan, Yingzi / Astakhov, Yury / Iureva, Tatyana / Adewale, Adeniyi / Walker, Thomas M. ·Beijing Tongren Eye Center, Beijing, People's Republic of China. · Tri-Service General Hospital, Taipei, Taiwan. · Peking University First Hospital, Beijing, People's Republic of China. · Pavlov First Saint Petersburg State Medical University, Saint Petersburg, Russia. · Irkutsk Branch of the Academician S.N. Fyodorov Eye Microsurgery Federal State Institution, Irkutsk, Russia. · Novartis Pharmaceuticals Corporation, Fort Worth, TX, USA. ·Clin Ophthalmol · Pubmed #32158181.

ABSTRACT: Objective: To demonstrate that the intraocular pressure (IOP)-lowering efficacy of a twice-daily brinzolamide 10 mg/mL (BRINZ)/brimonidine 2 mg/mL (BRIM) fixed-dose combination (BBFC) was non-inferior to its individual components (BRINZ+BRIM) dosed concomitantly in patients with open-angle glaucoma (OAG) or ocular hypertension (OHT). Safety was also evaluated. Methods and Analysis: This was a Phase III, multicenter, observer-masked study in patients from China, Russia and Taiwan. Patients aged ≥18 years with a mean IOP ≥21 mmHg and ≤36 mmHg in the same eye after washout of other IOP-lowering medications were included. Eligible patients were randomized (1:1) to receive BBFC or BRIZ+BRIM eye drops twice daily for 3 months. The primary endpoint was the mean change in diurnal IOP (averaged over 09:00, +2 h, and +7 h) from baseline to Month 3. Adverse events (AEs) were recorded throughout the study. Results: The per-protocol set included 349 patients (BBFC, n=172; BRINZ+BRIM, n=177). The mean±standard deviation diurnal IOP at baseline was 24.6±2.66 mmHg in both groups. At Month 3, the least square mean±standard error change in diurnal IOP from baseline was -7.2±0.34 mmHg and -7.3±0.34 mmHg with BBFC and BRINZ+BRIM, respectively (between-group difference: 0.1 mmHg [95% CI -0.5, 0.7]). In the BBFC and BRINZ+BRIM groups, 53.3% and 55.0% of patients achieved a diurnal IOP <18 mmHg, and 43.2% and 37.4% of patients, respectively, achieved a mean diurnal IOP reduction >30% from baseline at Month 3. Ocular AEs were reported in 28.7% (BBFC) and 22.5% (BRINZ+BRIM) of patients; conjunctival hyperemia was the most frequent ocular AE (BBFC, 6.4%; BRINZ+BRIM, 6.8%). Non-ocular AEs were reported in 32.4% (BBFC) and 30.4% (BRINZ+BRIM) of patients. Conclusion: The study findings demonstrate that the efficacy of twice-daily BBFC was non-inferior to BRINZ+BRIM in patients with OAG/OHT. The safety profile of BBFC was similar to that of BRINZ+BRIM.

23 Article Disease-related and age-related changes of anterior chamber angle structures in patients with primary congenital glaucoma: An in vivo high-frequency ultrasound biomicroscopy-based study. 2020

Shi, Yan / Han, Ying / Xin, Chen / Hu, Man / Oatts, Julius / Cao, Kai / Wang, Huaizhou / Wang, Ningli. ·Beijing Tongren Eye Center, Beijing Tongren Hospital, Beijing Institute of Ophthalmology, Capital Medical University, Beijing, China. · Department of Ophthalmology, University of California, San Francisco School of Medicine, San Francisco, CA, United States of America. · Department of Ophthalmology, National Key Discipline of Pediatrics, Ministry of Education, Beijing Children's Hospital, Capital Medical University, Beijing, China. ·PLoS One · Pubmed #31990918.

ABSTRACT: OBJECTIVES: To provide in vivo measurements of anterior chamber angle structures and their relationship with age as evaluated by high-frequency ultrasound biomicroscopy (UBM) in patients with primary congenital glaucoma (PCG). METHODS: High-frequency UBM was done for 51 PCG eyes from 40 patients (aged from 3 to 96 months) and 11 unaffected contralateral eyes. Parameters, including the proportion of observable abnormal tissue membrane and Schlemm's canal, the largest cross-sectional area (CSA) of Schlemm's canal (SC), SC meridional diameter, trabecular-iris angle (TIA), trabecular meshwork (TM) thickness, iris thickness, ciliary process length, and corneal limbus thickness were compared between the two groups and their relationship with age was explored in PCG eyes. RESULTS: Abnormal tissue membrane was detected in 27.5% of PCG eyes and none in unaffected eyes. SC was observed in 73.1% of PGC eyes compared to 100% in unaffected eyes (P<0.001). The largest CSA of SC, SC meridional diameter, iris thickness, and corneal limbus thickness were all significantly smaller in PCG eyes compared to unaffected eyes (all P<0.05). TIA and ciliary process length in unaffected eyes were smaller than PCG eyes (both P<0.05). The largest CSA of SC, TM thickness, iris thickness, and ciliary process length were all significantly correlated to age in PCG eyes (P<0.05). CONCLUSIONS: The anatomical information evaluated by high-frequency UBM may provide glaucoma specialists a useful tool to aid in understanding the dysgenesis and changes with age of anterior chamber angle in PCG.

24 Article Is kidney function associated with primary open-angle glaucoma? Findings from the Asian Eye Epidemiology Consortium. 2020

Tham, Yih-Chung / Tao, Yijin / Zhang, Liang / Rim, Tyler Hyung Taek / Thakur, Sahil / Lim, Zhi Wei / Chee, Miao Li / Bikbov, Mukharram M / Kazakbaeva, Gyulli M / Wang, Ningli / Cao, Kai / Hao, Jie / Nangia, Vinay / Panda-Jonas, Songhomitra / Wang, Ya Xing / Wong, Ian Y / Chan, Jonathan Cheuk Hung / Meng, Qianli / Sabanayagam, Charumathi / Wong, Tien Y / Jonas, Jost B / Zhong, Hua / Cheng, Ching-Yu / Anonymous2751059. ·Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore. · Ophthalmology and Visual Science Academic Clinical Program, Duke-NUS Medical School, Singapore, Singapore. · Department of Ophthalmology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China. · Department of Ophthalmology, Severance Hospital, Institute of Vision Research, Yonsei University College of Medicine, Seoul, Republic of Korea. · Faculty of Medicine, University of New South Wales, Sydney, New South Wales, Australia. · Ufa Eye Research Institute, Ufa, Bashkortostan, Russian Federation. · Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology and Visual Sciences, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. · Suraj Eye Institute, Nagpur, Maharashtra, India. · Department of Ophthalmology, Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. · Department of Ophthalmology, Hong Kong Sanatorium and Hospital, Hong Kong SAR, China. · Department of Ophthalmology, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China. · Department of Ophthalmology, Guangdong Eye Institute, Guangdong Provincial People's Hospital, Guangzhou, Guangdong, China. · Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. · Singapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore chingyu.cheng@duke-nus.edu.sg. ·Br J Ophthalmol · Pubmed #31959588.

ABSTRACT: AIM: To comprehensively examine the association between kidney function and primary open angle glaucoma (POAG) in a large consortium of multiple Asian population-based studies. METHODS: 28 925 participants (57 340 eyes) from 9 population-based studies (from China, Hong Kong, India, Korea, Russia, Singapore) of the Asian Eye Epidemiology Consortium were included. Across all studies, POAG was defined based on the International Society of Geographical and Epidemiological Ophthalmology criteria. Estimated glomerular filtration rate (eGFR) was calculated from serum creatinine. Chronic kidney disease (CKD) was defined as eGFR<60 mL/min/1.73 m RESULTS: After adjusting for age, gender, study group, hypertension, diabetes, hyperlipidaemia, body mass index, smoking status and IOP, lower eGFR (per 10 mL/min/1.73 m CONCLUSION: In this large pooled-analysis of multiple Asian population-based studies, our findings suggest that the association between CKD and POAG may only be present in East Asians specifically but not in the overall Asian population. Further evaluation in Japanese population is warranted to confirm this observation.

25 Article [Changes and development of glaucoma in China in the past 70 years]. 2020

Wang, N L / Liu, X Y. ·Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Ophthalmology, Beijing Key Laboratory of Ophthalmology & Visual Sciences, Beijing 100730, China. · Xiamen Eye Center of Xiamen University, Xiamen 361016, China. ·Zhonghua Yan Ke Za Zhi · Pubmed #31937056.

ABSTRACT: Glaucoma is a major irreversible blindness-causing disease. Traditional Chinese Medicine literature have mentioned glaucoma since Qin and Han Dynasties. Progress has been made since 1949, especially in these 50 years. Since 1990, rapid progress has been achieved in the field of glaucoma, including the research of pathogenesis, education, training and establishment of diagnosis and treatment standard for glaucoma. Nowadays, Chinese glaucoma specialists are giving out more and more voice in the international platform. Though the outcome is delightful, we realize that we are still lack of original innovations. After all, the road is still long and rugged, more efforts should be put into the fight against glaucoma.

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