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Glaucoma: HELP
Articles by Ning Li Wang
Based on 139 articles published since 2008
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Between 2008 and 2019, N. L. Wang wrote the following 139 articles about Glaucoma.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6
1 Editorial [Emphasizing the technological specification of glaucoma examination to promote mutual recognition to the results]. 2014

Wang, Ningli. ·Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China. Email: wningli@vip.163.com. ·Zhonghua Yan Ke Za Zhi · Pubmed #25052798.

ABSTRACT: It is very important for us to establish the technological specifications in medical field. Many problems will appear if we neglect them, which include difficulty in approving the results of examination with each other, waste of medical resources and increase of patients' time and expense, lack of guarantee for medical quality and safety and insupportable for further study with collecting medical data, etc. Although many technical operations were included in glaucoma field, unified technical specification was still deficiency in our country, which will have some certain influence on the clinical and research work. Only increasing the understanding of importance of technological specifications and establishing the applications of glaucoma's technical specifications, our whole level of glaucoma diagnosis and treatment will be raised in the whole country.

2 Editorial [Emphasis on promotion of the adaptive technology is the sky point of improving of treatment and prevention level of glaucoma]. 2013

Wang, Ning-li. ·Beijing Tongren Eye Center,Beijing Tongren Hospital, Capital Medical University, Beijing institute of Ophthalmology, Beijing Ophthalmology & Visual Science Key Lab., Beijing 100730, China. Email: wningli@vip.163.com. ·Zhonghua Yan Ke Za Zhi · Pubmed #24512993.

ABSTRACT: Promoting the control of primary angle-closure glaucoma (PACG) and primary open angle glaucoma (POAG) is most important prevention program of blindness in China. PACG has been incorporated into the prevention program of blindness in China based on the population-based screening studies. However, the clinical screening should be strengthened in POAG. The creation of a series of appropriate technologies suitable for glaucoma prevention and management has been achieved in China, especially for PACG. The technologies have been evaluated in the pilot areas and obtained very good results in China. It is recommended to develop new technology suitable for glaucoma management using the following workflow: research, development, and evaluation by large scale hospitals, and then clinical trial in the pilot areas. After a cost-benefit analysis is made, the new technology can be promoted and applied in clinical practice nationwide. We propose to gradually formed a strategical mode of "screening in township hospitals, intervention in county hospitals, and technical support and tackling in provincial hospitals" in order to improve the level of prevention and treatment of glaucoma and reduce the blindness incidence rate caused by glaucoma.

3 Editorial Perspective of genetic approaches to eye diseases. 2009

Xu, Xun / Wang, Ning. · ·Chin Med J (Engl) · Pubmed #19951595.

ABSTRACT: -- No abstract --

4 Review Mechanism of the reconstruction of aqueous outflow drainage. 2018

Xin, Chen / Tian, Ning / Li, Meng / Wang, Huaizhou / Wang, Ningli. ·Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China. · Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, 100005, China. · Department of ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China. · Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, 100005, China. wningli@vip.163.com. · Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, 100005, China. wningli@vip.163.com. ·Sci China Life Sci · Pubmed #29282607.

ABSTRACT: Glaucoma is the leading cause of irreversible blindness worldwide. The reconstruction of aqueous outflow drainage (RAOD) has recently been proposed to aid in restoring aqueous outflow drainage in primary open-angle glaucoma. However, the mechanism of RAOD remains to be fully understood. Based on literature review and research studies, the potential mechanisms of RAOD are the following: (i) Circumferential dilation of the Schlemm's canal (SC) and surrounding collector channels. (ii) Instant formation of microcracks through RAOD procedures. (iii) Formation of more pores, and local detachment between the SC endothelium (SCE) and basement membrane. (iv) Activation of stem cells by constant mechanical stress caused by the tensional suture placed at the anterior part of the SC. (v) Reversal of trabecular meshwork (TM) herniation. (vi) Mobilization of the reserve of the aqueous drainage. (vii) Change of SCE phenotype. (viii) Mechanosensing and mechanotransducing of TM.

5 Review Why does acute primary angle closure happen? Potential risk factors for acute primary angle closure. 2017

Zhang, Xiulan / Liu, Yaoming / Wang, Wei / Chen, Shida / Li, Fei / Huang, Wenbin / Aung, Tin / Wang, Ningli. ·Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China. Electronic address: zhangxl2@mail.sysu.edu.cn. · Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China. · Singapore Eye Research Institute and Singapore National Eye Centre, Singapore; Department of Ophthalmology, National University of Singapore, Singapore. · Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. ·Surv Ophthalmol · Pubmed #28428109.

ABSTRACT: Acute primary angle closure is an ocular emergency and requires immediate management to avoid blindness. Narrow anterior chamber angle, advanced age, female gender, and Asian ethnic background are considered risk factors for acute primary angle closure. The predictive power of these factors is, however, relatively poor, and many questions remain unanswered because acute primary angle closure eventually develops in only a relatively small proportion of anatomically predisposed eyes. We summarize the potential roles of various factors in the pathogenesis of acute primary angle closure.

6 Review [Diagnosis and treatment of ocular hypertension]. 2016

Sun, Y Y / Chen, W W / Wang, N L. ·Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital of Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing 100730, China. ·Zhonghua Yan Ke Za Zhi · Pubmed #27531115.

ABSTRACT: Ocular hypertension is popular among people, with a prevalence of 3% to 10% in those older than 40 years old. Without proper intervention, over 10% of the patients with ocular hypertension would develop glaucoma in the following 5 to 10 years. Glaucoma has become one of the leading causes of blindness all over the world, which makes it essential for us to pay enough attention to the prevention and treatment of ocular hypertension. However, it is not cost-effective to treat all the patients with ocular hypertension. Certain side effects may also be caused with long-term medical treatment. Therefore, it is of great importance for ophthalmologists to identify the right time and use appropriate therapeutic methods. To introduce the knowledge of ocular hypertension, the definition, epidemiology, diagnosis, risk factors and treatment of ocular hypertension are reviewed in this article. (Chin J Ophthalmol, 2016, 52: 542-546).

7 Review Translamina Cribrosa Pressure Difference as Potential Element in the Pathogenesis of Glaucomatous Optic Neuropathy. 2016

Jonas, Jost B / Wang, Ningli / Yang, Diya. ·From the *Department of Ophthalmology, Medical Faculty Mannheim, Ruprecht-Karls-University, Seegartenklinik Heidelberg, Germany; †Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory; and ‡Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. ·Asia Pac J Ophthalmol (Phila) · Pubmed #26713405.

ABSTRACT: The main proven risk factor for glaucomatous optic neuropathy (GON) is an intraocular pressure (IOP) higher than the pressure sensibility of the optic nerve head allows. Fulfilling Koch postulates, numerous studies have shown that the presence of high IOP leads to GON, that lowering IOP stops the progression of GON, and that a re-increase in IOP again causes the progression of GON. There are, however, many patients with glaucoma who have statistically normal or low IOP, and despite low IOP values, they develop progressing GON. These observations led to findings that IOP is only 1 of 2 determinants of the translamina cribrosa pressure difference (TLCPD), which is the main pressure-related parameter for the physiology and pathophysiology of the optic nerve head. The second parameter influencing TLCPD is orbital cerebrospinal fluid pressure (CSFP) as the counter pressure against IOP across the lamina cribrosa. Recent experimental and clinical studies have suggested that a low CSFP could be associated with GON in normal-pressure glaucoma. These investigations included studies with an experimental long-term reduction in CSFP in monkeys, population-based studies, and clinical retrospective and prospective investigations on patients with normal-pressure glaucoma. Besides TLCPD, other ocular parameters influenced by CSFP may be choroidal thickness, retinal vein pressure and diameter, occurrence of retinal vein occlusions, and occurrence and severity of diabetic retinopathy.

8 Review Choroidal physiology and primary angle closure disease. 2015

Zhang, Xiulan / Wang, Wei / Aung, Tin / Jonas, Jost B / Wang, Ningli. ·Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China. Electronic address: zhangxl2@mail.sysu.edu.cn. · Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-Sen University, Guangzhou, China. · Glaucoma Service, Singapore National Eye Centre, Singapore. · Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University of Heidelberg, Seegartenklinik, Heidelberg, Germany. · Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Science Key Laboratory, Beijing, China. ·Surv Ophthalmol · Pubmed #26164737.

ABSTRACT: Primary angle closure disease (PACD), prevalent in Asian countries, is generally associated with a shallower anterior chamber, a shorter axial length, thicker lens, hyperopia, and female sex. Other physiologic factors, however, may be important, especially with regard to triggering acute primary angle closure. Thickening of the choroid has been demonstrated in untreated and treated, acute and chronic PACD eyes. Recently, there has been growing interest in studying the role of the choroid in the pathophysiology of PACD. The emergence of new imaging technology such as the enhanced depth imaging mode of spectral-domain optical coherence tomography and swept-source optical coherence tomography has contributed to understanding PACD pathologies. We summarize the functions of the choroid and choroidal changes in the pathogenesis of PACD, and discuss potential future developments.

9 Review Facts and myths of cerebrospinal fluid pressure for the physiology of the eye. 2015

Jonas, Jost B / Wang, Ningli / Yang, Diya / Ritch, Robert / Panda-Jonas, Songhomitra. ·Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Seegartenklinik, Heidelberg, Germany; Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, China. · Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, China; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. Electronic address: wningli@vip.163.com. · Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology and Visual Sciences Key Laboratory, Beijing, China. · Einhorn Clinical Research Center, New York Ear Eye and Ear Infirmary of Mt. Sinai, New York, NY, USA. · Department of Ophthalmology, Medical Faculty Mannheim of the Ruprecht-Karls-University, Seegartenklinik, Heidelberg, Germany. ·Prog Retin Eye Res · Pubmed #25619727.

ABSTRACT: The orbital cerebrospinal fluid pressure (CSFP) represents the true counter-pressure against the intraocular pressure (IOP) across the lamina cribrosa and is, therefore, one of the two determinants of the trans-lamina cribrosa pressure difference (TLPD). From this anatomic point of view, an elevated TLPD could be due to elevated IOP or abnormally low orbital CSFP. Both experimental and clinical studies have suggested that a low CSFP could be associated with glaucomatous optic neuropathy in normal-pressure glaucoma. These included monkey studies with an experimental long-term reduction in CSFP, and clinical retrospective and prospective studies on patients with normal-pressure glaucoma. Since the choroidal blood drains via the vortex veins through the superior ophthalmic vein into the intracranial cavernous sinus, anatomy suggests that the CSFP could influence choroidal thickness. A population-based study revealed that thicker subfoveal choroidal thickness was associated with higher CSFP. Since the central retinal vein passes through the orbital CSF space, anatomy suggests that the retinal venous pressure should be at least as high as the orbital CSFP. Other experimental, clinical or population-based studies suggested an association between higher CSFP and higher retinal venous pressure and wider retinal veins. Consequently, a higher estimated CSFP was associated with arterial hypertensive retinopathy (with respect to the dilated retinal vein diameter and higher arterial-to-venous diameter) and with the prevalence, severity and incidence of diabetic retinopathy. Physiologically, CSFP was related with higher IOP. The influence of the CSFP on the episcleral venous pressure and/or a regulation of both CSFP and IOP by a center in the dorsomedial/perifornical hypothalamus may be responsible for this. In summary, the CSFP may be an overlooked parameter in ocular physiology and pathology. Abnormal changes in the CSFP, in particular in relationship to the IOP, may have pathophysiologic importance.

10 Review Initial Treatment for Primary Angle-Closure Glaucoma in China. 2015

Liang, Yuan Bo / Wang, Ning Li / Rong, Shi Song / Thomas, Ravi. ·*The Affiliated Eye Hospital, School of Optometry and Ophthalmology, Wenzhou Medical University, Wenzhou, Zhejiang Province †Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong ‡Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing, China §Queensland Eye Institute, University of Queensland, Qld, Australia. ·J Glaucoma · Pubmed #24786102.

ABSTRACT: China has a large burden of primary angle-closure glaucoma (PACG) and the approach to treatment is different from that in most parts of the world. In China, trabeculectomy is a mainstay of initial treatment for PACG and laser peripheral iridotomy is reserved for PAC and PACG with peripheral angle synechiae ≤180 degrees. The greater reduction of and more stable IOP, lower frequency of acute angle closure, decreased progression of peripheral anterior synechia and glaucoma, and the reduction of ocular complications associated with long-term use of glaucoma medications support the use of initial trabeculectomy in PACG without significant lens opacities. Further study is required to determine the indications and effectiveness of initial trabeculectomy for PACG in a developing country setting.

11 Review [Research progress of the side effect of the prostaglandin drugs]. 2013

Liu, Xu-yang / Tang, Li / Peng, Yu-hao / Chen, Xiao-ming / Wang, Ning-li. · ·Zhonghua Yan Ke Za Zhi · Pubmed #24555212.

ABSTRACT: Glaucoma is one of the leading causes of blindness , second to cataract. Lowering intraocular pressure is the most effective therapeutic means for this disease, with prostaglandin analogs as the first-line medication. These drugs are efficacious and safe, with well-tolerated local adverse effects. They are also generally regarded to have almost no systemic untoward effect. Nonetheless, with the continuous rise in their popularity, systemic adverse effects caused by topical ocular use of prostaglandins have attracted increasing attention. These adverse effects include digestive, respiratory, and cardiovascular systems, as well as skin and hair. Although the incidence of these adverse effects is low, physicians need to be aware of their occurrence. Research progress of the prostacyclin class lOP-lowering medication side effects are reviewed.

12 Review [Research progress in intraocular pressure monitoring of glaucoma]. 2013

Hao, Jie / Zhen, Yi / Ma, Jian-min / Wang, Ning-li. ·Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. · Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. Email: wningli@vip.163.com. ·Zhonghua Yan Ke Za Zhi · Pubmed #24330937.

ABSTRACT: Elevation of intraocular pressure (IOP) is a major risk factor for the development and the progression in glaucoma optic nerve damage. The reduction of IOP remains mainstream strategy of glaucoma therapy. A large fluctuation of IOP in the circadian rhythm may play a role in the optic nerve damage in glaucoma progression. IOP monitoring provides important information of IOP mean, peak and fluctuation to assist the diagnosis and treatment of glaucoma. With the development of technology, the commonly used methods of IOP monitoring including IOP measurement for diurnal, 24 hours, and habitual body position have evolved to continuous IOP-monitoring using novel device. The influencing factors including tonometer, body position and the light have been taken into account for the reliability of IOP measurement. In this review, we summarized the recent progress in IOP monitoring and the factors affecting the IOP measurements and discussed immense opportunity of IOP-monitoring to better diagnose and to treat for glaucoma.

13 Review Intracranial pressure and glaucoma. 2013

Jonas, Jost B / Yang, Diya / Wang, Ningli. ·Department of Ophthalmology, Medical Faculty Mannheim-Heidelberg, Mannheim, Germany. ·J Glaucoma · Pubmed #23733115.

ABSTRACT: Eyes with normal-tension and high-tension glaucoma can have a similar optic nerve head appearance, which differs markedly from the optic disc appearance in vascular optic neuropathies. Factors in addition to intraocular pressure (IOP) may play a role in the pathogenesis of glaucomatous optic neuropathy. Clinical and experimental studies have shown (1) physiologic associations between cerebrospinal fluid pressure (CSFP), systemic arterial blood pressure, IOP, and body mass index; (2) that a low CSFP was associated with the development of glaucomatous optic nerve damage in cats; and (3) that patients with normal-tension glaucoma had significantly lower CSFP and a higher trans-lamina cribrosa pressure difference when compared to normal subjects. Due to anatomic reasons, the orbital CSFP and the optic nerve tissue pressure (and not the atmospheric pressure) form the retro-laminar counter-pressure against the IOP and are thus part of the trans-lamina cribrosa pressure difference and gradient. Assuming that an elevated trans-lamina cribrosa pressure difference and a steeper trans-lamina cribrosa pressure gradient are important for glaucomatous optic nerve damage, a low orbital CSFP would therefore play a role in the pathogenesis of normal-tension glaucoma. Due to the association between CSFP and blood pressure, a low blood pressure would also be indirectly involved.

14 Review Low cerebrospinal fluid pressure in the pathogenesis of primary open-angle glaucoma: epiphenomenon or causal relationship? The Beijing Intracranial and Intraocular Pressure (iCOP) study. 2013

Wang, Ningli / Yang, Diya / Jonas, Jost B. ·Department of Ophthalmology, Beijing Tongren Eye Center, Beijing Institute of Ophthalmology, Beijing, China. ·J Glaucoma · Pubmed #23733114.

ABSTRACT: Previous experimental and clinical investigations have suggested that some patients with primary open-angle glaucoma may have an abnormally low orbital cerebrospinal fluid pressure (CSFP). A meta-analysis of available clinical data showed a marked overlap in lumbar CSFP measurements between patients with normal-tension glaucoma and healthy subjects, so that the question arises as to which additional factors play a role in the pathogenesis of glaucomatous optic neuropathy.

15 Review [Physical exercise and intraocular pressure]. 2011

Liang, Yuan-bo / Wu, Yue / Li, Si-zhen / Sun, Lan-ping / Wang, Ning-li. ·Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China. yuanboliang@gmail.com ·Zhonghua Yan Ke Za Zhi · Pubmed #22177134.

ABSTRACT: In the 1960s, it had been observed that physical exercises could reduce the intraocular pressure (IOP) in patients with glaucoma. However, the effect of IOP reduction varied with exercise type and intensity, as well as the duration after exercise. Difference of lowering the IOP in glaucoma patients and healthy people were also observed. The mechanisms of reducing the IOP by exercise were very complicated and believed to be associated with the lower concentration of norepinephrine, the rising of colloid osmotic pressure, the co-action of nitric oxide and endothelin after exercise, and also related to the gene polymorphism of β2-adrenergic receptor. Physical exercise, such as jogging, walking and bicycle riding, could be suggested as a complimentary therapy in addition to the pharmaceutical and surgical therapies available for glaucoma patients, even though the mechanism for lowering IOP is not clear enough.

16 Review [Clinical observation on glaucoma filtering blebs in vivo]. 2008

Xin, Chen / Wang, Ning-li / Qiao, Li-ya. ·Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China. ·Zhonghua Yan Ke Za Zhi · Pubmed #18953903.

ABSTRACT: Filtering surgery is an effective and a most commonly used technique in managing glaucoma. However, the failure of surgery is often caused by the scar formation of the filtering pathway. It is important for clinicians to evaluate the morphology and the function of the filtering bleb, especially in the early period of post-operation when IOP is normal. The success of surgery relies upon the early intervention whenever the filtering bleb showing the tendency of scarring. This paper reviews recent development in the observation and the treatment of glaucoma filtering blebs.

17 Clinical Trial One-year interim comparison of canaloplasty in primary open-angle glaucoma following failed filtering surgery with primary canaloplasty. 2016

Xin, Chen / Chen, Xiaoya / Shi, Yan / Li, Meng / Wang, Huaizhou / Wang, Ningli. ·Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. · Department of Ophthalmology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. · Department of Ophthalmology, Xuzhou 1st Hospital, Jiangsu, China. ·Br J Ophthalmol · Pubmed #27060163.

ABSTRACT: BACKGROUND/AIMS: This study was to explore the 1-year interim efficacy and safety of canaloplasty for primary open-angle glaucoma (POAG) with failed glaucoma filtration surgery (GFS) but an intact Schlemm's canal (SC). METHODS: This was a single-surgeon prospective clinical study. Patients with POAG scheduled for canaloplasty were included and divided into two groups (with or without failed GFS). The status of SC was determined by gonioscopy and ultrasound biomicroscopy. Primary outcome measures included intraocular pressure (IOP) and glaucoma medication use at various follow-up points. The secondary outcome measure was the rate of surgical success. RESULTS: Thirty-seven eyes were enrolled in group 1 (no GFS) and 23 eyes were enrolled in group 2 (failed GFS). The mean IOP (16.0±1.6 vs 16.2±1.6 mm Hg) and the number of medications (0.3±0.8 vs 0.3±0.6) at 18 months after canaloplasty were not significantly different between the two groups. There was no significant difference in complete success rate (criteria A: 52.2% vs 59.5%, p=0.587; criteria B: 39.1% vs 48.6%, p=0.343), as well as the qualified success rate (criteria A: 86.5% vs 82.6%, p=0.668; criteria B: 78.4% vs 69.6%, p=0.445). In group 2, the age, sex, number of previous surgeries, time span between operations were not significantly associated with surgery failure (p=0.199, 0.747, 0.977 and 0.615). Hyphaema was the most common postoperative complications. CONCLUSIONS: Canaloplasty is an effective and safe option for POAG with failed GFS but an intact SC. TRIAL REGISTRATION NUMBER: ChiCTR-ICR-15005788, Results.

18 Clinical Trial Intraocular pressure lowering efficacy and safety of travoprost 0.004% as a replacement therapy in patients with open angle glaucoma or ocular hypertension. 2010

Ge, Jian / Sun, Xing-huai / Wang, Ning-li / Zhao, Jia-liang / Wu, Ling-ling / Chen, Xiao-ming / Wang, Zhi-xin / Li, Benny. ·Zhongshan Ophthalmic Center, State Key Laboratory of Ophthalmology, Sun Yat-sen University, Guangzhou, Guangdong 510060, China. gejian@mail.sysu.edu.cn ·Chin Med J (Engl) · Pubmed #20819599.

ABSTRACT: BACKGROUND: Travoprost has been widely used for the treatment of patients with open-angle glaucoma (OAG) or ocular hypertension (OH). The aim of this study was to evaluate the intraocular pressure (IOP) lowering efficacy of travoprost 0.004% monotherapy in patients previously treated with other topical hypotensive medications, and in previously untreated patients. METHODS: This open-label, 12-week study in 1651 adult patients with ocular hypertension or open-angle glaucoma who were untreated or required a change in therapy (due to either inadequate efficacy or safety issues) as judged by the investigator was conducted at 6 sites in China. Previously treated patients were instructed to discontinue their prior medications at the first visit. All the patients were dosed with travoprost 0.004% once-daily at 8 p.m. in both eyes for 12 weeks. Efficacy and safety evaluations were conducted at week 4 and 12. IOP measurements were performed at the same time of day at the follow-up visits. RESULTS: For patients transitioned to travoprost, mean IOP reductions from baseline in untreated and treated patients with different prior medications at week 12 were: latanoprost, (4.3 +/- 4.6) mmHg; beta-blocker, (6.3 +/- 4.0) mmHg; alpha-agonist, (7.5 +/- 4.3) mmHg; topical carbonic anhydrase inhibitors, (8.0 +/- 4.9) mmHg. All mean IOP changes from baseline were statistically significant (P < 0.001). No treatment-related serious adverse events were reported in this study. CONCLUSIONS: In patients treated with other hypotensive medications or untreated, the IOP reduction with travoprost was significant. The results of this study demonstrated the potential benefit of using travoprost as a replacement therapy in order to ensure adequate IOP control. Travoprost administered once daily was safe and well tolerated in patients with glaucoma or ocular hypertension.

19 Article [Preliminary study on the measurement of optic nerve subarachnoid space in patients with normal tension glaucoma]. 2018

Liu, H R / Yang, D Y / Ma, T / Shi, W Y / Chen, Y H / Pang, R Q / Du, J L / Zhu, Q / Wang, N L. ·Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing 100730, China. ·Zhonghua Yan Ke Za Zhi · Pubmed #30440153.

ABSTRACT:

20 Article Quantification of Pulse-Dependent Trabecular Meshwork Motion in Normal Humans Using Phase-Sensitive OCT. 2018

Xin, Chen / Song, Shaozhen / Johnstone, Murray / Wang, Ningli / Wang, Ruikang K. ·Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. · Department of Bioengineering, University of Washington, Seattle, Washington, United States. · Department of Ophthalmology, University of Washington, Seattle, Washington, United States. ·Invest Ophthalmol Vis Sci · Pubmed #30029254.

ABSTRACT: Purpose: The purpose of this study was to characterize the pulsatile motion of trabecular meshwork (TM) in normal subjects and demonstrate its changes in accommodation with phase-sensitive optical coherence tomography (PhS-OCT). Methods: A new PhS-OCT laboratory prototype was designed to measure pulsatile TM motion in 13 healthy humans. Two sets of images were captured in 10 subjects, first with best corrective refraction and the other with an additional 3.0 diopters of accommodation. In each image, both maximum velocity (MV) and cumulative displacement (CD) in two selected regions of TM, the internal (IMV and ICD) and external (EMV and ECD) region, were measured. Results: For all parameters the intraclass correlation coefficient was >0.75. Neither MV nor CD was significantly different between eyes in individual subjects (PIMV = 0.967, PEMV = 0.391, PICD = 0.603, PECD = 0.482). In 26 eyes, with best corrective refraction, the EMV was higher than the IMV (23.9 ± 9.8 vs. 18.9 ± 8.08 μm/s; P = 0.0001), as was the ECD compared with the ICD (0.340 ±0.125 vs. 0.264 ± 0.111 μm; P = 0.000004). With accommodation, MV and CD significantly increased (PIMV = 0.0003, PEMV = 0.0003, PICD = 0.019, and PECD = 0.007), whereas MV and CD in the external region were still larger than those in the internal area (PEMV vs. IMV = 0.009, PECD vs. ICD = 0.023). Conclusions: This study demonstrates the differences in TM motion between the internal and external regions of TM and displays its change with accommodation. The findings and good reproducibility suggest PhS-OCT helps to understand TM function in regulation of IOP, and, with further refinements, it may be useful in clinical management of glaucoma.

21 Article Reduced Functional and Anatomic Interhemispheric Homotopic Connectivity in Primary Open-Angle Glaucoma: A Combined Resting State-fMRI and DTI Study. 2018

Wang, Qian / Chen, Weiwei / Wang, Huaizhou / Zhang, Xun / Qu, Xiaoxia / Wang, Ying / Li, Ting / Wang, Ningli / Xian, Junfang. ·Department of Radiology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. · Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing, China. ·Invest Ophthalmol Vis Sci · Pubmed #29677346.

ABSTRACT: Purpose: To investigate if abnormal interhemispheric homotopic functional connectivity were accompanied by corresponding anatomic connectivity changes in primary open-angle glaucoma (POAG) patients, and to relate connectivity changes with retinal nerve fiber layer (RNFL) thickness and ganglion cell complex (GCC) thickness. Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) and diffusion tensor imaging (DTI) were performed in 16 POAG patients and 19 healthy controls. Indices of interhemispheric homotopic functional connectivity and the underlying anatomic connectivity changes were derived with voxel-base whole-brain voxel-mirrored homotopic connectivity (VMHC) analyses and VMHC-guided probabilistic tractography. Pearson correlation analyses were used to explore the correlations between interhemispheric homotopic functional connectivity changes and anatomic connectivity alterations, and RNFL and GCC thickness. Results: Reduced VMHC values between bilateral homotopic cortical areas located in Brodmann area (BA)17, BA18, and BA19. Decreased anatomic connectivity connecting bilateral visual cortical areas inside BA17 and BA18 were observed in POAG patients. Furthermore, positive correlations between average RNFL thickness and reduced VMHC values of BA17 (r = 0.572, P = 0.021)/BA18 (r = 0.600, P = 0.014)/BA19 (r = 0.550, P = 0.027) are found using Pearson correlation analyses. Conclusions: Combinations of interhemispheric homotopic functional connectivity and anatomic connectivity changes may help to elucidate the mechanism of interhemispheric synchronization injury in POAG patients. Reduced VMHC values positively correlate with glaucomatous changes of RNFL thickness, which strengthens the hypothesis that POAG affects the visual cortex using a novel functional MRI characteristic.

22 Article Matricellular Proteins Play a Potential Role in Acute Primary Angle Closure. 2018

Wang, Jing / Fu, Mingshui / Liu, Kun / Wang, Ning / Zhang, Zhihua / Zhou, Minwen / Xu, Xun. ·a Department of Ophthalmology , Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China. · b Shanghai Key Laboratory of Fundus Disease , Shanghai , China. ·Curr Eye Res · Pubmed #29558210.

ABSTRACT: PURPOSE: To quantify levels of matricellular proteins in aqueous humor samples from acute primary angle closure (APAC) and non-glaucomatous cataract eyes and investigate their correlation with intraocular pressure (IOP) fluctuation. MATERIALS AND METHODS: Aqueous humor samples were collected from 63 eyes including 29 current APAC eyes, 12 previous APAC eyes, and 22 cataract eyes. Concentrations of four main matricellular proteins (SPARC, tenascin-C, thrombospondin-2, and osteopontin) were measured using multiplexed immunoassay kits. Correlations between matricellular proteins and age, sex, and IOP were then detected using Spearman's rank correlation coefficient. RESULTS: The levels of SPARC, thrombospondin-2, and osteopontin were significantly elevated in the APAC group as compared to the cataract group (p < 0.001, p < 0.001, and p = 0.009, respectively). Further separation of the APAC group into current and previous APAC groups showed that only the differences of SPARC and thrombospondin-2 between the current APAC and cataract groups were significant (both p < 0.001). All four matricellular proteins were found to have a positive correlation with IOP in the current APAC group but no correlation was found in the previous APAC or cataract groups. CONCLUSIONS: The levels of matricellular proteins were significantly elevated in the current APAC eyes and positively correlated to IOP. Further studies are necessary to investigate the molecular mechanisms and histological evidence of pathogenesis in matricellular proteins in APAC.

23 Article [Prioritize the standardization of clinical diagnosis and treatment of glaucoma]. 2018

Wang, N L / Qiao, C Y. ·Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab., Beijing 100730, China. ·Zhonghua Yan Ke Za Zhi · Pubmed #29518873.

ABSTRACT: The standardization of clinical diagnosis and treatment of glaucoma is crucial to ensuring the quality of medical treatment and yielding high quality results in clinical research. Based on the results of a questionnaire survey, this paper analyzes the reasons for the gap between the current situations of glaucoma diagnosis and treatment in China and the international and domestic guidelines and consensus, emphasizes the importance of standardization in clinical diagnosis and treatment, and discusses the feasible strategies for improving the standardization of diagnosis and treatment.The goal is to improve glaucoma diagnosis and treatment service capability, bridge the gap between reality and domestic and international guidelines and consensus, and further standardize the management of glaucoma as a chronic disease, through efforts in strengthening training and promoting standardization.

24 Article Safety and Efficiency of Trabectome-mediated Trabecular Meshwork Ablation for Chinese Glaucoma Patients: A Two-year, Retrospective, Multicentre Study. 2018

Dang, Ya-Long / Cen, Yu-Jie / Hong, Ying / Huang, Ping / Wang, Ning-Li / Wang, Chao / Zhang, Chun / Anonymous2570937. ·Department of Ophthalmology, Peking University Third Hospital, Beijing 100191, China. · Department of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing 100005, China. · Department of Ophthalmology, University of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. ·Chin Med J (Engl) · Pubmed #29451146.

ABSTRACT: Background: The aim of the study was to evaluate the long-term safety and efficacy of the Trabectome for Chinese glaucoma patients. Methods: This was a multicenter, retrospective, observational study. Glaucoma patients, except those with neovascular glaucoma, with/without a visually significant cataract were enrolled. The patients received Trabectome or a combined surgery with phacoemulsification and intraocular lens implantation. The primary outcome evaluation was a reduction in intraocular pressure (IOP), and the secondary outcomes were a reduction in glaucoma medication, the 2-year success percentages, and complications. Success was defined as an IOP <21 mmHg and at least a 20% IOP reduction from baseline after 3 months for any two consecutive visits, without additional glaucoma surgery. The data were processed using the R Stats Package version 3.0.0. The Wilcoxon test was used to compare the postoperative IOP and the number of glaucoma medications with baselines. The Kaplan-Meier test was used to calculate the 2-year success percentage. The risk factors related to Trabectome failure were determined by logistic regression. Results: A total of 120 glaucoma patients were enrolled. The Trabectome efficiently reduced the IOP from a baseline of 22.8 ± 1.34 mmHg to 17.6 ± 0.96 mmHg, and the use of glaucoma medications from 2.2 ± 0.17 mmHg to 1.4 ± 0.21 in a 2-year follow-up (both, P < 0.01). The overall success percentage was 80%. No risk factor related to Trabectome failure was identified. No vision-threatening complication was observed. Ten patients, who required secondary glaucoma surgery, all reached the target IOP. Conclusions: In a 2-year follow-up, Trabectome was an efficient and safe procedure for Chinese glaucoma patients.

25 Article Measurement and Associations of the Optic Nerve Subarachnoid Space in Normal Tension and Primary Open-Angle Glaucoma. 2018

Liu, Hanruo / Yang, Diya / Ma, Teng / Shi, Wenyuan / Zhu, Qiang / Kang, Jun / Wang, Ningli. ·Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. · Beijing Institute of Ophthalmology, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Electronic address: wningli@vip.163.com. ·Am J Ophthalmol · Pubmed #29246580.

ABSTRACT: PURPOSE: To measure the area of the optic nerve subarachnoid space (ONSASA) in patients with normal tension glaucoma (NTG), primary open-angle glaucoma (POAG), and controls and examine its association with relevant ocular and systemic parameters. DESIGN: Cross-sectional study. METHODS: The study included 40 patients with NTG, 42 with POAG, and 45 healthy controls. B-scan ultrasound was performed binocularly, using a 12.5-MHz linear array probe. The measurement of the optic nerve subarachnoid space (ONSAS) and calculation of the ONSASA using ImageJ 1.51e analysis software was done by 2 experienced observers in a masked manner. RESULTS: The ONSASA between 3 and 7 mm behind the globe in NTG (5.15 ± 0.81 mm CONCLUSIONS: The ONSASA is smaller in NTG as compared to normal control. This is compatible with a lower cerebrospinal fluid pressure in the optic nerve in NTG, implying that trans-lamina cribrosa pressure difference might be abnormally higher in the NTG group than in normal controls.

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