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Glaucoma: HELP
Articles from France
Based on 577 articles published since 2009
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These are the 577 published articles about Glaucoma that originated from France during 2009-2019.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4 · 5 · 6 · 7 · 8 · 9 · 10 · 11 · 12 · 13 · 14 · 15 · 16 · 17 · 18 · 19 · 20
1 Editorial [Ocular hypertension after intravitreal injection, foreword]. 2017

Denis, P / Pisella, P-J. ·Hospices civils de Lyon, hôpital de la Croix-Rousse, 103, boulevard de la Croix-Rousse, 69317 Lyon cedex 04, France; CHU de Tours, 2, boulevard Tonnelle, 37000 Tours, France. ·J Fr Ophtalmol · Pubmed #28318714.

ABSTRACT: -- No abstract --

2 Editorial [Editorial]. 2015

Rouland, J-F. ·Service d'ophtalmologie, hôpital Huriez, avenue Polonowski, 59037 Lille cedex, France. Electronic address: jfrouland@chru-lille.fr. ·J Fr Ophtalmol · Pubmed #25842147.

ABSTRACT: -- No abstract --

3 Review Diffuse Iris Melanoma: Conservative Treatment with Proton Beam Therapy after Limbal Stem Cell Preservation or Enucleation? 2019

Leblanc, Alice / Lumbroso-Le Rouic, Livia / Desjardins, Laurence / Dendale, Rémi / Cassoux, Nathalie. ·Département d'Ophtalmologie, Institut Curie, Paris, France. · Département d'Ophtalmologie, Institut Curie, Poitiers, France. · ICPO - Centre de Protonthérapie de l'Institut Curie à Orsay, Paris, France. · Université Paris V Descartes, Paris, France. ·Ocul Oncol Pathol · Pubmed #31768362.

ABSTRACT: Objectives: Iris melanomas represent 2-3% of uveal melanomas; the diffuse variant accounts for approximately 10% of all iris melanomas. Different treatment modalities for diffuse iris melanomas (DIM) have been proposed depending on the local status as well as the age and general condition of the patient. Methods: This study is a single-centre retrospective case series describing the diagnosis, treatments and outcomes of DIM. Treatment consisted of enucleation or proton beam therapy (PT) of the whole anterior segment. Patients who were treated with PT benefitted from limbal stem cell preservation before irradiation. Results: Between 1996 and 2016, a total of 14 patients with DIM presented to our institution and were included in the database. The global survival was 86%. The median follow-up was 4.6 years (range 4 months to 15 years). Only 1 patient (7%) developed metastatic disease of the DIM (gastric location). No patient developed liver metastasis. Seven patients were treated by enucleation and 7 by PT after limbal stem cell preservation. After a conservative attempt, local tumour recurrence occurred in 2 patients at 2 years, requiring enucleation. The cornea was clear after irradiation in all patients. Cataract ( Conclusions: DIM is a very rare tumour. The global survival is excellent. Conservative treatment with PT is an efficient alternative to enucleation and allows good local tumour control. Cataract and glaucoma are the main radiation-related complications, but the corneal status was excellent due to the stem cell harvest prior to radiotherapy.

4 Review Tear Film Osmolarity, Ocular Surface Disease and Glaucoma: A Review. 2019

Fogagnolo, Paolo / Torregrossa, Giulia / Tranchina, Laura / Ferreras, Antonio / De Cillá, Stefano / Labbé, Antoine / Figus, Michele / Ottobelli, Laura / Rossetti, Luca. ·Eye Clinic, San Paolo Hospital, University of Milan, Milan, Italy. · Department of Ophthalmology, Miguel Servet University Hospital, University of Zaragoza, Zaragoza, Spain. · Unit of Ophthalmology, Ospedale Maggiore della Carita, Novara, Italy. · Department of Ophthalmology III, Quinze-Vingts National Ophthalmology Hospital, Vision Institute, Versailles Saint-Quentin en Yvelines University, 75012 Paris, France. · Ophthalmology, Department of Neurosciences, University of Pisa, Pisa, Italy. ·Curr Med Chem · Pubmed #31345142.

ABSTRACT: Glaucoma is the second leading cause of blindness in the world, affecting more than 60 million people globally. In order to reduce the progression of the disease, both medical and surgical treatments are used. Frequent side effects of both treatments include a range of modifications of the ocular surface grouped as the Ocular Surface Disease (OSD), which include Dry Eye Disease (DED). DED and other OSD negatively impact on the success of anti-glaucoma treatments and reduce the adherence to medical therapies. Tear film osmolarity (TFO) is a relatively novel test which has become a hallmark of DED. The aim of this paper was to review the association between OSD, DED and glaucoma in view of published TFO data, and to discuss future fields of research and treatments on the topic of glaucoma iatrogenic damage.

5 Review Systematic Review of Economic Evaluations in Primary Open-Angle Glaucoma: Decision Analytic Modeling Insights. 2019

Bartelt-Hofer, Jose / Ben-Debba, Lilia / Flessa, Steffen. ·Ernst Moritz Arndt University of Greifswald, Greifswald, Germany. jose.bartelthofer@stud.uni-greifswald.de. · Dauphine University, Paris, France. · Ernst Moritz Arndt University of Greifswald, Greifswald, Germany. ·Pharmacoecon Open · Pubmed #31111447.

ABSTRACT: OBJECTIVE: Our objective was to review, compare and gain insight into economic evaluations in primary open-angle glaucoma (POAG) with a focus on existing decision analytic models. METHODS: A literature review was performed using clinical and specialized databases following best practices. Relevant inclusion criteria included the development of a decision analytic model, the assessment of POAG interventions, and a full economic evaluation in terms of costs and health-related outcomes. Model inputs and settings were extracted, compared and analyzed. Main study incremental outcomes were also reported. RESULTS: The literature review identified 22 full articles in alignment with the eligibility criteria for a total of 15 countries and a wide range of years from 1983 to 2018. Interventions included as competing alternatives in the eligible studies were topical medications (33%), screening or diagnosis (33%), surgical interventions (10%), laser trabeculoplasty (10%) and minimally invasive surgeries (3%). Markov models using transition states were the most common type of modeling approach. Cost-utility models using a mid- to long-term time horizon with a national payer perspective were the most frequent type of economic evaluation identified. Model states commonly included disease severity levels, as defined by glaucoma staging systems, and other relevant events such as blindness and death. Authors did not sufficiently justify key modeling assumptions, inputs or the robustness of their findings. CONCLUSIONS: Decision analytic models in POAG can reasonably guide future modeling research by revealing common practices, inputs and assumptions. Furthermore, this review revealed evidence gaps in terms of unexplored interventions and treatment sequences.

6 Review [Congenital aniridia in children]. 2019

Bremond-Gignac, Dominique. ·Service d'ophtalmologie, hôpital Necker Enfants-malades, AP-HP, centre de maladies rares OPHTARA, université Paris-Descartes, université Sorbonne-Paris-Cité, Paris, France. Unité CNRS FR3636, université Paris-Descartes, université Sorbonne-Paris-Cité, Paris, France. Coordonnateur du Centre OPHTARA maladies rares en Ophtalmologie, Centre Européen ERN EYE. Présidente du CMS Geniris et Aniridia Europe. ·Rev Prat · Pubmed #30983291.

ABSTRACT: Congenital aniridia in children. Congenital aniridia is a genetic rare disease that affects the entire eyeball (pan-ocular disease). The disease is characterized by partial or complete absence of iris. Clinical signs in children are essentially photophobia and nystagmus. The prevalence was reported range from 1:40,000 births to 1:100,000 but may be underestimated. It can also be associated with other systemic disorders then constituting a syndromic aniridia. These different syndromes are to be detected rapidly at risk of nephroblastoma in WAGR syndrome (Wilms' tumor, aniridia, genitourinary anomalies, mental retardation) or cerebellar ataxia in Gillespie syndrome. The diagnosis is mostly performed in infants. Congenital aniridia combines several types of ocular disorders, such as aniridia, foveal hypoplasia, glaucoma, cataract, and progressive corneal opacification. Preventive therapies should be instituted and all ocular aspects of the disease should be treated. This disease often leads to major visual impairment or even long-term blindness and requires UV protection optical correction. Clinical research is active with corneal stem cells and gene therapy.

7 Review Glaucoma progression analysis by Spectral-Domain Optical Coherence Tomography (SD-OCT). 2019

Renard, J-P / Fénolland, J-R / Giraud, J-M. ·Centre du glaucome ophtalmologie, hôpital Bégin, 69, avenue de Paris, 94160 Saint-Mandé, France. Electronic address: pr_renard@yahoo.fr. · Centre du glaucome ophtalmologie, hôpital Bégin, 69, avenue de Paris, 94160 Saint-Mandé, France. ·J Fr Ophtalmol · Pubmed #30955899.

ABSTRACT: Spectral domain optical coherence tomography (SD-OCT) provides an objective quantification of the lesions of various target tissue structures in glaucoma, with unprecedented resolution, which has now demonstrated its interest in controlling the progression of glaucomatous neuropathy, from early stages to late stages. A certain number of well-established proofs state that a progressive modification in OCT is a common predictor of functional loss, and that patients with rapid OCT changes have an increased risk of developing glaucomatous scotoma. Follow-up of the progression goes through three stages. It consists first of all in detecting the evolution of damage to the retinal nerve fiber layer (RNFL), then that of the macular ganglion cell complex (GCC), in order to better define this progression of the damage to the target structures and, thirdly, to complete its analysis by integrating it with the analysis of the functional impairment. We note today that there is a greater risk of developing a future functional deficit of the visual field in subjects with a RNFL loss slope greater than -1/year, for all clinical stages of glaucoma. The characteristics of GCC progression are much better specified. Often earlier than that of the progress of the thinning of the RNFL and much faster in the subjects considered as "progressors", its cartography is better defined, with a particular interest for the follow-up of diversion maps and "wide field" acquisitions offering better visibility of deficits and their progression. To date, a certain number of suspicious indicators of short-term progress can be retained, highlighting the essential precaution of having two or more basic measures and a confirmation of the change on at least one new OCT acquisition. Finally, if the interpretation of the progression must always be based on clinical examination data, and the macula in particular, it remains crucial to confront the progression of the RNFL with that of the GCC and with that of the visual field.

8 Review [XEN 2019

Buffault, J / Baudouin, C / Labbé, A. ·Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France. · Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, université de Versailles Saint-Quentin-en-Yvelines, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne Billancourt, France; Inserm, U968, université UPMC Paris VI, UMR S 968, institut de la vision , CNRS, UMR 7210, 75012 Paris, France. · Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, université de Versailles Saint-Quentin-en-Yvelines, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne Billancourt, France; Inserm, U968, université UPMC Paris VI, UMR S 968, institut de la vision , CNRS, UMR 7210, 75012 Paris, France. Electronic address: dr.antoinelabbe@gmail.com. ·J Fr Ophtalmol · Pubmed #30879831.

ABSTRACT: PURPOSE: The purpose of this study was to analyze the change in intraocular pressure (IOP) and glaucoma medications using the XEN METHODS: We included cohort studies with at least one year of follow-up in patients with primary open angle glaucoma (POAG), pseudo-exfoliative glaucoma (PXG) or pigmentary glaucoma (PG) who received a XEN® gel stent. The main outcome measure was IOP reduction at 12 months follow-up. Secondary outcomes were the decrease in glaucoma medications 12 months after surgery, frequency and type of postoperative interventions and complication rate. RESULTS: A total of 8 case series published between 2016 and 2018 were included; six were prospective studies, and two were retrospective. There was no randomized controlled trial. The data concerned a total of 958 eyes of 777 patients. The various studies showed a mean IOP at 12 months between 13 and 16mmHg, which represented an IOP reduction between 25 and 56% (mean: 42%). This decrease was associated with a reduction in glaucoma medications in all studies. The decrease in IOP was significantly greater in XEN CONCLUSION: XEN

9 Review XEN 2019

Buffault, J / Baudouin, C / Labbé, A. ·Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU ForeSight, , 28, rue de Charenton, 75012 Paris, France. · Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU ForeSight, , 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, université de Versailles Saint-Quentin-en-Yvelines, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne-Billancourt, France; Inserm, U968, université UPMC Paris VI, UMR S 968, institut de la vision, CNRS, UMR 7210, 75012 Paris, France. · Service d'ophtalmologie, centre hospitalier national d'ophtalmologie des Quinze-Vingts, IHU ForeSight, , 28, rue de Charenton, 75012 Paris, France; Service d'ophtalmologie, hôpital Ambroise-Paré, université de Versailles Saint-Quentin-en-Yvelines, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne-Billancourt, France; Inserm, U968, université UPMC Paris VI, UMR S 968, institut de la vision, CNRS, UMR 7210, 75012 Paris, France. Electronic address: dr.antoinelabbe@gmail.com. ·J Fr Ophtalmol · Pubmed #30683533.

ABSTRACT: PURPOSE: The purpose of this study was to analyze the change in intraocular pressure (IOP) and glaucoma medications using the XEN METHODS: We included cohort studies with at least one year of follow-up in patients with primary open angle glaucoma (POAG), pseudo-exfoliative glaucoma (PXG) or pigmentary glaucoma (PG) who received a XEN RESULTS: A total of 8 case series published between 2016 and 2018 were included; six were prospective studies, and two were retrospective. There was no randomized controlled trial. The data concerned a total of 958 eyes of 777 patients. The various studies showed a mean IOP at 12 months between 13 and 16mmHg, which represented an IOP reduction between 25 and 56% (mean: 42%). This decrease was associated with a reduction in glaucoma medications in all studies. The decrease in IOP was significantly greater in XEN CONCLUSION: XEN

10 Review Prostaglandin analogues and nitric oxide contribution in the treatment of ocular hypertension and glaucoma. 2019

Impagnatiello, Francesco / Bastia, Elena / Almirante, Nicoletta / Brambilla, Stefania / Duquesroix, Brigitte / Kothe, Angela C / Bergamini, Michael V W. ·Nicox Research Institute, Milan, Italy. · Nicox SA, Valbonne Sophia Antipolis, France. · Silver Pharma Consulting, Inc., Buckeye, AZ, USA. · Nicox Ophthalmics, Inc., Fort Worth, TX, USA. · Nicox Ophthalmics, Inc., Research Triangle Park, NC, USA. ·Br J Pharmacol · Pubmed #29669171.

ABSTRACT: In patients with ocular hypertension or glaucoma, all treatments aim to lower intraocular pressure (IOP) by modulating aqueous humour (AH) production and/or uveoscleral and trabecular meshwork/Schlemm's canal AH drainage. PG analogues are considered to be the 'gold standard' treatment and are the most frequently used IOP-lowering agents. Recent data support an important role for NO in regulating IOP. Thus, novel PG analogues carrying a NO-donating moiety were recently advanced. Latanoprostene bunod (LBN) and NCX 470, NO-donating derivatives of latanoprost and bimatoprost, respectively, are examples of such compounds. LBN ophthalmic solution, 0.024% (Vyzulta™), showed greater IOP-lowering efficacy compared with that of Xalatan

11 Review Epigenetics in Age-related Macular Degeneration (AMD). 2018

Desmettre, T J. ·Centre de rétine médicale, 187, rue de Menin, 59520 Marquette-Lez-Lille, France; London International Medical Centre, 18-22 Queen Anne Street, London, W1G 8HU, United Kingdom. Electronic address: thomas@desmettre.org. ·J Fr Ophtalmol · Pubmed #30458925.

ABSTRACT: Age-related Macular Degeneration (AMD) is a complex multifactorial condition involving multiple genetic, environmental and constitutional factors. Inflammation, oxidative stress and lipid metabolism seem to be the most important factors in the pathogenesis of the disease. The importance of genetic factors has mainly been revealed with the influence of histocompatibility complement factor H (CFH) variations and the ARSM2 susceptibility gene. Another component, epigenetics, could help to explain some of the relationships between environmental and genetic factors. Epigenetics is defined as the study of modulations of gene activity that can be transmitted over cell divisions without involving mutation of the DNA sequence. The molecules that are involved in these mechanisms are referred to as the epigenome. The mechanisms involve DNA methylation, histone modification, chromatin remodeling, and gene inhibition by non-coding RNA. Epigenetics could explain how the environment may induce relatively stable changes in traits or even diseases, possibly inheritable over several generations. Epigenetic traits established during development, and/or acquired under the influence of nutritional factors or other environmental factors, could influence the interactions between genes and the environment. Several authors have recently shown the influence of epigenetic factors in the pathogenesis of ocular diseases such as cataract, dry eye, glaucoma, diabetic retinopathy and more recently AMD. A better understanding of the involvement of genetic variants at risk, their relationship with epigenetics and environmental factors would certainly help to better assess the risk of developing AMD or better understand recent changes in the incidence of the disease.

12 Review [Epigenetics in age-related macular degeneration (AMD) - French translation of the article]. 2018

Desmettre, T. ·Centre de rétine médicale, 187, rue de Menin, 59520 Marquette-Lez-Lille, France; London International Medical Centre, 18-22 Queen Anne Street, London, W1G 8HU, Royaume-Uni. Electronic address: thomas@desmettre.org. ·J Fr Ophtalmol · Pubmed #30454959.

ABSTRACT: Age-related macular degeneration (AMD) is a complex multifactorial condition involving multiple genetic, environmental and constitutional factors. Inflammation, oxidative stress and lipid metabolism seem to be the most important factors in the pathogenesis of the disease. The importance of genetic factors has mainly been revealed with the influence of histocompatibility complement factor H (CFH) variations and the ARSM2 susceptibility gene. Another component, epigenetics, could help to explain some of the relationships between environmental and genetic factors. Epigenetics is defined as the study of modulations of gene activity that can be transmitted over cell divisions without involving mutation of the DNA sequence. The molecules that are involved in these mechanisms are referred to as the epigenome. The mechanisms involve DNA methylation, histone modification, chromatin remodeling, and gene inhibition by non-coding RNA. Epigenetics could explain how the environment may induce relatively stable changes in traits or even diseases, possibly inheritable over several generations. Epigenetic traits established during development, and/or acquired under the influence of nutritional factors or other environmental factors, could influence the interactions between genes and the environment. Several authors have recently shown the influence of epigenetic factors in the pathogenesis of ocular diseases such as cataract, dry eye, glaucoma, diabetic retinopathy and more recently AMD. A better understanding of the involvement of genetic variants at risk, their relationship with epigenetics and environmental factors would certainly help to better assess the risk of developing AMD or better understand recent changes in the incidence of the disease.

13 Review Cyclodestructive Procedures in Glaucoma: A Review of Current and Emerging Options. 2018

Dastiridou, Anna I / Katsanos, Andreas / Denis, Philippe / Francis, Brian A / Mikropoulos, Dimitrios G / Teus, Miguel A / Konstas, Anastasios-Georgios. ·2nd Department of Ophthalmology, Aristotle University, Thessaloniki, Greece. · Department of Ophthalmology, University of Ioannina, Ioannina, Greece. · University Department of Ophthalmology, Lyons, France. · Doheny and Stein Eye Institutes, University of California Los Angeles (UCLA), Los Angeles, CA, USA. · 3rd University Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece. · Department of Ophthalmology, Hospital Universitario "Principe de Asturias", Universidad de Alcalá, Alcala De Henares, Spain. · 1st and 3rd University Departments of Ophthalmology, Aristotle University of Thessaloniki, Thessaloniki, Greece. konstas@med.auth.gr. ·Adv Ther · Pubmed #30448885.

ABSTRACT: The first surgical modalities to reduce aqueous humor production by damaging the ciliary body date back to the early twentieth century. Until recently, however, cyclodestructive procedures (e.g., cyclocryotherapy and transscleral diode laser photocoagulation) have been reserved as last option procedures in refractory glaucoma patients with poor visual potential. Emerging technologic innovation has led to the development of promising, safer and less destructive techniques, such as micropulse diode cyclophotocoagulation, endoscopic cyclophotocoagulation and ultrasound cyclodestruction. Consequently, an emerging paradigm shift is under way with the selection of these surgical options in eyes with less severe glaucoma and good visual potential. Although existing evidence has not, as yet, adequately defined the role and value of these procedures, their emergence is a welcome expansion of available options for patients with moderate-to-severe glaucoma. This article reviews the pertinent evidence on both established and evolving cyclodestructive techniques and describes their growing role in the management of glaucoma.

14 Review Pluripotent Stem Cell-Based Approaches to Explore and Treat Optic Neuropathies. 2018

Rabesandratana, Oriane / Goureau, Olivier / Orieux, Gaël. ·Sorbonne Université, INSERM, CNRS, Institut de la Vision, Paris, France. ·Front Neurosci · Pubmed #30294255.

ABSTRACT: Sight is a major sense for human and visual impairment profoundly affects quality of life, especially retinal degenerative diseases which are the leading cause of irreversible blindness worldwide. As for other neurodegenerative disorders, almost all retinal dystrophies are characterized by the specific loss of one or two cell types, such as retinal ganglion cells, photoreceptor cells, or retinal pigmented epithelial cells. This feature is a critical point when dealing with cell replacement strategies considering that the preservation of other cell types and retinal circuitry is a prerequisite. Retinal ganglion cells are particularly vulnerable to degenerative process and glaucoma, the most common optic neuropathy, is a frequent retinal dystrophy. Cell replacement has been proposed as a potential approach to take on the challenge of visual restoration, but its application to optic neuropathies is particularly challenging. Many obstacles need to be overcome before any clinical application. Beyond their survival and differentiation, engrafted cells have to reconnect with both upstream synaptic retinal cell partners and specific targets in the brain. To date, reconnection of retinal ganglion cells with distal central targets appears unrealistic since central nervous system is refractory to regenerative processes. Significant progress on the understanding of molecular mechanisms that prevent central nervous system regeneration offer hope to overcome this obstacle in the future. At the same time, emergence of reprogramming of human somatic cells into pluripotent stem cells has facilitated both the generation of new source of cells with therapeutic potential and the development of innovative methods for the generation of transplantable cells. In this review, we discuss the feasibility of stem cell-based strategies applied to retinal ganglion cells and optic nerve impairment. We present the different strategies for the generation, characterization and the delivery of transplantable retinal ganglion cells derived from pluripotent stem cells. The relevance of pluripotent stem cell-derived retinal organoid and retinal ganglion cells for disease modeling or drug screening will be also introduced in the context of optic neuropathies.

15 Review The Physiology of Homeoprotein Transduction. 2018

Di Nardo, Ariel A / Fuchs, Julia / Joshi, Rajiv L / Moya, Kenneth L / Prochiantz, Alain. ·Centre for Interdisciplinary Research in Biology (CIRB), Collège de France, CNRS UMR 7241, INSERM U1050, Labex MemoLife, PSL Research University , Paris , France. ·Physiol Rev · Pubmed #30067157.

ABSTRACT: The homeoprotein family comprises ~300 transcription factors and was long seen as primarily involved in developmental programs through cell autonomous regulation. However, recent evidence reveals that many of these factors are also expressed in the adult where they exert physiological functions not yet fully deciphered. Furthermore, the DNA-binding domain of most homeoproteins contains two signal sequences allowing their secretion and internalization, thus intercellular transfer. This review focuses on this new-found signaling in cell migration, axon guidance, and cerebral cortex physiological homeostasis and speculates on how it may play important roles in early arealization of the neuroepithelium. It also describes the use of homeoproteins as therapeutic proteins in mouse models of diseases affecting the central nervous system, in particular Parkinson disease and glaucoma.

16 Review Role of Optineurin in the Mitochondrial Dysfunction: Potential Implications in Neurodegenerative Diseases and Cancer. 2018

Weil, Robert / Laplantine, Emmanuel / Curic, Shannel / Génin, Pierre. ·Laboratory of Signaling and Pathogenesis, Institut Pasteur, CNRS UMR3691, Paris, France. ·Front Immunol · Pubmed #29971063.

ABSTRACT: Optineurin (Optn) is a 577 aa protein encoded by the

17 Review Systemic and Ocular Determinants of Peripapillary Retinal Nerve Fiber Layer Thickness Measurements in the European Eye Epidemiology (E3) Population. 2018

Mauschitz, Matthias M / Bonnemaijer, Pieter W M / Diers, Kersten / Rauscher, Franziska G / Elze, Tobias / Engel, Christoph / Loeffler, Markus / Colijn, Johanna Maria / Ikram, M Arfan / Vingerling, Johannes R / Williams, Katie M / Hammond, Christopher J / Creuzot-Garcher, Catherine / Bron, Alain M / Silva, Rufino / Nunes, Sandrina / Delcourt, Cécile / Cougnard-Grégoire, Audrey / Holz, Frank G / Klaver, Caroline C W / Breteler, Monique M B / Finger, Robert P / Anonymous4211447. ·Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Department of Ophthalmology, University of Bonn, Bonn, Germany. · Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands; Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands. · Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany. · Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany; Institute for Medical Informatics, Statistics and Epidemiology, Leipzig University, Leipzig, Germany. · Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany; Schepens Eye Research Institute, Harvard Medical School, Boston, Massachusetts. · Department of Epidemiology, Erasmus MC, Rotterdam, The Netherlands. · Department of Ophthalmology, Erasmus MC, Rotterdam, The Netherlands. · Section of Academic Ophthalmology, School of Life Course Sciences, FoLSM, King's College London, London, United Kingdom. · Department of Ophthalmology, University Hospital Dijon, Dijon, France; Eye and Nutrition Research Group, University of Bourgogne Franche Comté, Dijon, France. · Department of Ophthalmology, Centro Hospitalar e Universitário de Coimbra, Coimbra, Portugal; Faculty of Medicine, University of Coimbra, Institute for Biomedical Imaging and Life Sciences, Coimbra, Portugal; Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal. · Association for Innovation and Biomedical Research on Light and Image, Coimbra, Portugal. · University of Bordeaux, Inserm, Bordeaux Population Health Research Center, Team LEHA, Bordeaux, France. · Department of Ophthalmology, University of Bonn, Bonn, Germany. · Population Health Sciences, German Center for Neurodegenerative Diseases (DZNE), Bonn, Germany; Institute for Medical Biometry, Informatics and Epidemiology (IMBIE), Faculty of Medicine, University of Bonn, Bonn, Germany. · Department of Ophthalmology, University of Bonn, Bonn, Germany. Electronic address: robert.finger@ukbonn.de. ·Ophthalmology · Pubmed #29716786.

ABSTRACT: PURPOSE: To investigate systemic and ocular determinants of peripapillary retinal nerve fiber layer thickness (pRNFLT) in the European population. DESIGN: Cross-sectional meta-analysis. PARTICIPANTS: A total of 16 084 European adults from 8 cohort studies (mean age range, 56.9±12.3-82.1±4.2 years) of the European Eye Epidemiology (E3) consortium. METHODS: We examined associations with pRNFLT measured by spectral-domain OCT in each study using multivariable linear regression and pooled results using random effects meta-analysis. MAIN OUTCOME MEASURES: Determinants of pRNFLT. RESULTS: Mean pRNFLT ranged from 86.8±21.4 μm in the Rotterdam Study I to 104.7±12.5 μm in the Rotterdam Study III. We found the following factors to be associated with reduced pRNFLT: Older age (β = -0.38 μm/year; 95% confidence interval [CI], -0.57 to -0.18), higher intraocular pressure (IOP) (β = -0.36 μm/mmHg; 95% CI, -0.56 to -0.15), visual impairment (β = -5.50 μm; 95% CI, -9.37 to -1.64), and history of systemic hypertension (β = -0.54 μm; 95% CI, -1.01 to -0.07) and stroke (β = -1.94 μm; 95% CI, -3.17 to -0.72). A suggestive, albeit nonsignificant, association was observed for dementia (β = -3.11 μm; 95% CI, -6.22 to 0.01). Higher pRNFLT was associated with more hyperopic spherical equivalent (β = 1.39 μm/diopter; 95% CI, 1.19-1.59) and smoking (β = 1.53 μm; 95% CI, 1.00-2.06 for current smokers compared with never-smokers). CONCLUSIONS: In addition to previously described determinants such as age and refraction, we found that systemic vascular and neurovascular diseases were associated with reduced pRNFLT. These may be of clinical relevance, especially in glaucoma monitoring of patients with newly occurring vascular comorbidities.

18 Review [Pseudoexfoliation syndrome and pseudoexfoliation glaucoma]. 2018

Schweitzer, C. ·Service d'ophtalmologie, CHU de Bordeaux, 33000 Bordeaux, France; UMR 1219, Inserm, Bordeaux Population Health Research Center, team LEHA, université Bordeaux, 33000 Bordeaux, France. Electronic address: cedric.schweitzer@chu-bordeaux.fr. ·J Fr Ophtalmol · Pubmed #29329947.

ABSTRACT: Pseudoexfoliation syndrome is an age-related systemic disease that mainly affects the anterior structures of the eye. Despite a worldwide distribution, reported incidence and prevalence of this syndrome vary widely between ethnicities and geographical areas. The exfoliative material is composed mainly of abnormal cross-linked fibrils that accumulate progressively in some organs such as the heart, blood vessels, lungs or meninges, and particularly in the anterior structures of the eye. The exact pathophysiological process still remains unclear but the association of genetic and environmental factors are thought to play a role in the development and progressive extracellular accumulation of exfoliative material. Hence, LOXL1 gene polymorphisms, responsible for metabolism of some components of elastic fibers and extracellular matrix, and increased natural exposure to ambient ultraviolet or caffeine consumption have been associated with pseudoexfoliation syndrome. Ophthalmological manifestations are commonly bilateral with an asymmetric presentation and can lead to severe visual impairment and blindness more frequently than in the general population, mainly related to glaucoma and cataract. Pseudoexfoliation glaucoma is a major complication of pseudoexfoliation syndrome and represents the main cause of identifiable glaucoma worldwide. Visual field progression is more rapid than that observed in primary open angle glaucoma, and filtering surgery is more frequently required. Nuclear cataract is more frequent and occurs earlier than in the general population. Owing to poorer pupil dilation and increased zonular instability, cataract surgery with pseudoexfoliation is associated with a 5- to 10-fold increase in surgical complications compared to cataract surgery without pseudoexfoliation. Some specific treatments targeting production, formation or accumulation of exfoliative material could improve the prognosis of this syndrome.

19 Review Diseases of the retina and the optic nerve associated with obstructive sleep apnea. 2018

Mentek, Marielle / Aptel, Florent / Godin-Ribuot, Diane / Tamisier, Renaud / Pepin, Jean-Louis / Chiquet, Christophe. ·Grenoble Alpes University, HP2 Laboratory, INSERM U1042, Grenoble, France. · Grenoble Alpes University, HP2 Laboratory, INSERM U1042, Grenoble, France; Department of Ophthalmology, University Hospital of Grenoble, Grenoble, France. · Grenoble Alpes University, HP2 Laboratory, INSERM U1042, Grenoble, France; Pôle Thorax et Vaisseaux, University Hospital of Grenoble, Grenoble, France. · Grenoble Alpes University, HP2 Laboratory, INSERM U1042, Grenoble, France; Department of Ophthalmology, University Hospital of Grenoble, Grenoble, France. Electronic address: christophe.chiquet@inserm.fr. ·Sleep Med Rev · Pubmed #29107469.

ABSTRACT: Many associations between ocular disorders and obstructive sleep apnea (OSA) have been studied, such as nonarteritic anterior ischemic optic neuropathy, glaucoma, papilledema, retinal vein occlusion, eyelid hyperlaxity, lower-eyelid ectropion and recurrent corneal erosions. The objective of this review is to synthetize the possible vascular disorders of the retina and the optic nerve associated with sleep apnea patients and to discuss the underlying pathophysiological hypotheses. Main mechanisms involved in the ocular complications of OSA are related to intermittent hypoxia, sympathetic system activation, oxidant stress, and deleterious effects of endothelin 1. The main evidence-based medicine data suggest that OSA should be screened in patients with ischemic optic neuropathy and diabetic retinopathy. The effect of OSA treatment and emerging therapies are discussed.

20 Review The Role of the P2X7 Receptor in Ocular Stresses: A Potential Therapeutic Target. 2017

Dutot, Mélody / Olivier, Elodie / Wakx, Anaïs / Rat, Patrice. ·UMR 8638 CNRS COMETE, Université Paris Descartes, Sorbonne Paris Cité, Faculté de Pharmacie, 4 Avenue de l'Observatoire, 75006 Paris, France. · Recherche et Développement, Laboratoire d'Evaluation Physiologique, Yslab, 2 rue Félix Le Dantec, 29000 Quimper, France. ·Vision (Basel) · Pubmed #31740640.

ABSTRACT: The P2X7 receptor is expressed in both anterior and posterior segments of the eyeball. In the ocular surface, the P2X7 receptor is activated in case of external aggressions: preservatives and surfactants induce the activation of P2X7 receptors, leading to either apoptosis, inflammation, or cell proliferation. In the retina, the key endogenous actors of age-related macular degeneration, diabetic retinopathy, and glaucoma act through P2X7 receptors' activation and/or upregulation of P2X7 receptors' expression. Different therapeutic strategies aimed at the P2X7 receptor exist. P2X7 receptor antagonists, such as divalent cations and Brilliant Blue G (BBG) could be used to target either the ocular surface or the retina, as long as polyunsaturated fatty acids may exert their effects through the disruption of plasma membrane lipid rafts or saffron that reduces the response evoked by P2X7 receptor stimulation. Treatments against P2X7 receptor activation are proposed by using either eye drops or food supplements.

21 Review [Role of laser peripheral iridotomy in pigmentary glaucoma and pigment dispersion syndrome: A review of the literature [French version]]. 2017

Buffault, J / Leray, B / Bouillot, A / Baudouin, C / Labbé, A. ·Service d'ophtalmologie, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne-Billancourt, France; DHU Sight Restore, université de Versailles Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines, France. · Service d'ophtalmologie, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne-Billancourt, France; DHU Sight Restore, université de Versailles Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines, France; Service d'ophtalmologie 3, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France. · Service d'ophtalmologie, hôpital Ambroise-Paré, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne-Billancourt, France; DHU Sight Restore, université de Versailles Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines, France; Service d'ophtalmologie 3, centre hospitalier national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France. Electronic address: dr.antoinelabbe@gmail.com. ·J Fr Ophtalmol · Pubmed #29050926.

ABSTRACT: PURPOSE: Pigment dispersion syndrome (PSD) is characterized by a structural abnormality of the posterior surface of the iris causing contact with the zonular fibers. It can lead to an open-angle glaucoma secondary to pigment dispersion into the trabecular meshwork. Laser peripheral iridotomy (PI) has been proposed as a treatment for pigmentary glaucoma (PG) and pigment dispersion syndrome (PDS) by reducing the dispersion of pigment. The goal of this review was to assess the effects of PI for PSD and PG. METHODS: We included six randomized controlled trials and two cohort studies (286 eyes of 218 participants). Four trials included participants with PG, and 4 trials enrolled participants with PSD with or without elevated intraocular pressure (IOP). RESULTS: Among patients with PG, at an average of 9 months of follow-up, the mean difference in IOP between groups was 2.69mmHg less in the PI group (95 % CI: -6.05 to 0.67; 14 eyes). In patients with PDS, the average IOP was statistically lower after PI as compared to baseline (Student test, t=11.49, P<0.01). With regard to visual field progression in participants with GP, after an average follow-up of 28 months, the risk of progression was not influenced by PI (RR 1.00 95 %: CI 0.16 to 6.25; 32 eyes). No trials that enrolled patients with PSD showed a diminution of the risk of glaucoma conversion at mid- and long-term. CONCLUSION: PI decreases the biomechanical factor causing contact between the iris and zonular fibers and may lower IOP over the long-term. Nevertheless, the effects of PI on visual field changes or progression have not been established in PG and PDS. There is no scientific evidence as of yet to advocate PI as a treatment for PDS or PG.

22 Review Role of laser peripheral iridotomy in pigmentary glaucoma and pigment dispersion syndrome: A review of the literature. 2017

Buffault, J / Leray, B / Bouillot, A / Baudouin, C / Labbé, A. ·Department of ophthalmology, Ambroise-Paré hospital, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne Billancourt, France; DHU Sight Restore, université de Versailles-Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines, France. · Department of ophthalmology, Ambroise-Paré hospital, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne Billancourt, France; DHU Sight Restore, université de Versailles-Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines, France; Department of ophthalmology 3, Quinze-Vingts national ophthalmology hospital, 28, rue de Charenton, 75012 Paris, France. · Department of ophthalmology, Ambroise-Paré hospital, AP-HP, 9, avenue Charles-De-Gaulle, 92100 Boulogne Billancourt, France; DHU Sight Restore, université de Versailles-Saint-Quentin-en-Yvelines, Saint-Quentin-en-Yvelines, France; Department of ophthalmology 3, Quinze-Vingts national ophthalmology hospital, 28, rue de Charenton, 75012 Paris, France. Electronic address: dr.antoinelabbe@gmail.com. ·J Fr Ophtalmol · Pubmed #28987446.

ABSTRACT: PURPOSE: Pigment dispersion syndrome (PDS) is characterized by a structural abnormality of the posterior surface of the iris causing contact with the zonular fibers. It can lead to an open-angle glaucoma secondary to pigment dispersion into the trabecular meshwork. Laser peripheral iridotomy (PI) has been proposed as a treatment for pigmentary glaucoma (PG) and pigment dispersion syndrome (PDS) by reducing the dispersion of pigment. The goal of this review was to assess the effects of PI for PDS and PG. METHODS: We included six randomized controlled trials and two cohort studies (286 eyes of 218 participants). Four trials included participants with PG, and 4 trials enrolled participants with PDS with or without elevated intraocular pressure (IOP). RESULTS: Among patients with PG, at an average of 9 months of follow-up, the mean difference in IOP between groups was 2.69mm Hg less in the PI group (95% CI: -6.05 to 0.67; 14 eyes). In patients with PDS, the average IOP was statistically lower after PI as compared to baseline (Student test t=11.49, P<0.01, 38 eyes). With regard to visual field progression in participants with PG, after an average follow-up of 28 months, the risk of progression was not influenced by PI (RR 1.00 95% CI: 0.16 to 6.25; 32 eyes). No trials that enrolled patients with PDS showed a diminution of the risk of glaucoma conversion at mid- and long-terms. CONCLUSION: PI decreases the biomechanical factor causing contact between the iris and zonular fibers and may lower IOP over the long-term. Nevertheless, the effects of PI on visual field changes or progression have not been established in PG and PDS. There is no scientific evidence as of yet to advocate PI as a treatment for PDS or PG.

23 Review [Retinal vein occlusions]. 2017

Pierru, A / Girmens, J-F / Héron, E / Paques, M. ·Centre national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France. Electronic address: alexpierru@gmail.com. · Centre national d'ophtalmologie des Quinze-Vingts, 28, rue de Charenton, 75012 Paris, France. ·J Fr Ophtalmol · Pubmed #28916115.

ABSTRACT: Retinal venous occlusions comprise central retinal vein occlusion, hemiretinal vein occlusions, and branch retinal vein occlusions. They are associated with arterial hypertension and glaucoma. Retinal vein occlusions occur more frequently in males, at a median age of 55. The pathogenesis of retinal venous occlusions remains obscure. The clinical presentation of the disease is variable. In most cases, there is a unilateral visual loss over days with a painless, white and quiet eye. However, retinal venous occlusions may also present as an abrupt and profound loss of vision, or be asymptomatic. The course of the disease may be chronic, often with exacerbations. The most severe complication is the onset of extensive capillary non-perfusion, with a high risk of neovascular glaucoma. The most frequent complication is macular edema due to breakdown of the blood-retinal barrier, which can originate from the macula itself and/or from the disc. The treatment is symptomatic. Retinal venous occlusions may resolve either because of the recanalization of the affected vein, or because of the establishment of an efficient collateral circulation. Intravitreal anti-VEGF antibodies or steroids may transiently improve vision, as well as laser photocoagulation, focused or not on macroaneurysms. Visual sequelae are frequent.

24 Review Management of postoperative inflammation after cataract and complex ocular surgeries: a systematic review and Delphi survey. 2017

Aptel, Florent / Colin, Cyrille / Kaderli, Sema / Deloche, Catherine / Bron, Alain M / Stewart, Michael W / Chiquet, Christophe / Anonymous670915. ·Department of Ophthalmology, Joseph Fourier University, Grenoble, France. · Pôle IMER, Hospices Civils de Lyon, Lyon, Rhône-Alpes, France. · Solid Drug Development SA, Genève, Switzerland. · Department of Ophthalmology, University Hospital, Dijon, France. · Department of Ophthalmology, Mayo Clinic College of Medicine, Jacksonville, Florida, USA. ·Br J Ophthalmol · Pubmed #28774934.

ABSTRACT: Prevention and management of postoperative ocular inflammation with corticosteroids and non-steroidal anti-inflammatory drugs (NSAIDs) have been evaluated in several randomised controlled trials (RCTs). However, neither consensus regarding the efficacies of different regimens nor established guidelines are currently available. This has resulted in different practice patterns throughout the world. A systematic literature review found that for the management of postcataract inflammation nepafenac produced a positive outcome in three of three RCTs (3/3), as did ketorolac (1/1), bromfenac (7/7), loteprednol (3/3) and difluprednate (6/6), but not flurbiprofen (0/1). A single study found that betamethasone produced inconclusive results after retinal detachment (RD) surgery; ketorolac was effective (1/1) after vitrectomy, but triamcinolone was ineffective (0/1) after trabeculectomy. A two-round Delphi survey asked 28 international experts to rate both the inflammatory potential of different eye surgeries and their agreement with different treatment protocols. They rated trabeculectomy, RD surgery and combined phacovitrectomy as more inflammatory than cataract surgery. Vitrectomies for macular hole or epiretinal membrane were not deemed more inflammatory than cataract surgery. For trabeculectomy, they preferred to treat longer than for cataract surgery (NSAID + corticosteroid three times a day for 2 months vs 1 month). For vitrectomy alone, RD surgery and combined phacovitrectomy, the panel preferred the same treatment as for cataract surgery (NSAID + corticosteroid three times a day for 1 month). The discrepancy between preferred treatment and perception of the eye's inflammatory status by the experts for RD and combined vitreoretinal surgeries highlights the need for RCTs to establish treatment guidelines.

25 Review [Ophthalmology in 2016 : the advent of ocular biomarkers]. 2017

Matet, Alexandre / Daruich, Alejandra / Behar-Cohen, Francine. ·Université de Lausanne, Département d'ophtalmologie, Fondation Asile des aveugles, Hôpital ophtalmique Jules-Gonin, 1011 Lausanne. · INSERM UMR 1138, Université Paris Descartes, Centre de Recherche des Cordeliers, 15, rue de l'Ecole de médecine, 75006 Paris, France. ·Rev Med Suisse · Pubmed #28703544.

ABSTRACT: Precision medicine is the future. In all fields of medicine, optimized therapy aims at identifying individuals at risks in order to prevent diseases, to identify specific molecular targets in a specific patient, at a specific time, to administer optimized treatment with less side effects. To achieve this ambitious aim, biomarkers, which should be specific and sensitive predictive indicators of diseases, or of response to treatment or of a state of evolution of the disease, must be identified. The eye offers an easy access organ to collect directly media or tissue, which can serve to identify such markers. This paper summarizes recent advances in the identification of ocular biomarkers of ocular diseases but also of brain diseases.

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