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Gout: HELP
Articles by Mohammad U. Ahmed
Based on 1 article published since 2010
(Why 1 article?)

Between 2010 and 2020, Mohammad U. Ahmed wrote the following article about Gout.
+ Citations + Abstracts
1 Review Repositioning of drugs using open-access data portal DTome: A test case with probenecid (Review). 2016

Ahmed, Mohammad U / Bennett, Dylan J / Hsieh, Tze-Chen / Doonan, Barbara B / Ahmed, Saba / Wu, Joseph M. ·Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA. ·Int J Mol Med · Pubmed #26572802.

ABSTRACT: The one gene-one enzyme hypothesis, first introduced by Beadle and Tatum in the 1940s and based on their genetic analysis and observation of phenotype changes in Neurospora crassa challenged by various experimental conditions, has witnessed significant advances in recent decades. Much of our understanding of the association between genes and their phenotype expression has benefited from the completion of the human genome project, and has shown continual transformation guided by the effort directed at the annotation and characterization of human genes. Similarly, the idea of one drug‑one primary disease indication that traditionally has been the benchmark for the labeling and usage of drugs has also undergone evident progressive refinements; in recent years the science and practice of pharmaceutical development has notable success in the strategy of drug repurposing. Drug repurposing is an innovative approach where, instead of de novo synthesis and discovery of new drugs with novel indications, drug candidates with the desired usage are identified by a process of re‑profiling using an open‑source database or knowledge of known or failed drugs already in existence. In the present study, the repurposing drug strategy employing open‑access data portal drug‑target interactome (DTome) is applied to the uncovering of new clinical usage for probenecid.