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Gout: HELP
Articles by Lynette D. Fairbanks
Based on 2 articles published since 2008

Between 2008 and 2019, Lynette Fairbanks wrote the following 2 articles about Gout.
+ Citations + Abstracts
1 Article Acute effect of milk on serum urate concentrations: a randomised controlled crossover trial. 2010

Dalbeth, Nicola / Wong, Sumwai / Gamble, Greg D / Horne, Anne / Mason, Barbara / Pool, Bregina / Fairbanks, Lynette / McQueen, Fiona M / Cornish, Jillian / Reid, Ian R / Palmano, Kate. ·Department of Medicine, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Rd., Grafton, Auckland, New Zealand. n.dalbeth@auckland.ac.nz ·Ann Rheum Dis · Pubmed #20472590.

ABSTRACT: OBJECTIVES: Recent observational studies have highlighted the beneficial role of dairy ingestion in gout prevention. The aims of this study were to determine the acute effects of milk ingestion on serum urate concentrations and examine the mechanisms of these effects. METHODS: This was a short-term randomised controlled crossover trial of milk in 16 healthy male volunteers. The following products were tested (each 80 g protein): soy control, early season skim milk, late season skim milk (containing high concentrations of orotic acid, a naturally occurring uricosuric agent) and ultrafiltrated MPC 85 skim milk. Each participant received a single dose of each product in random order. Serum and urine were obtained immediately before and then hourly over a 3 h period after ingestion of each study product. RESULTS: Ingestion of the soy control led to an increase in serum urate concentrations by approximately 10%. In contrast, ingestion of all milks led to a decrease in serum urate concentrations by approximately 10% (p<0.0001). All products (including soy) rapidly increased the fractional excretion of uric acid (FEUA). Late season milk led to a greater increase in FEUA than MPC 85 (p=0.02) and early season milk (p=0.052). There were no differences over time in serum oxypurines or purine-containing nucleosides. However, all products increased the fractional excretion of xanthine. CONCLUSIONS: Intact milk has an acute urate-lowering effect. These data provide further rationale for long-term intervention studies to determine whether such dietary interventions have an adjunctive role in the management of individuals with hyperuricaemia and gout.

2 Article SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. 2008

Vitart, Veronique / Rudan, Igor / Hayward, Caroline / Gray, Nicola K / Floyd, James / Palmer, Colin N A / Knott, Sara A / Kolcic, Ivana / Polasek, Ozren / Graessler, Juergen / Wilson, James F / Marinaki, Anthony / Riches, Philip L / Shu, Xinhua / Janicijevic, Branka / Smolej-Narancic, Nina / Gorgoni, Barbara / Morgan, Joanne / Campbell, Susan / Biloglav, Zrinka / Barac-Lauc, Lovorka / Pericic, Marijana / Klaric, Irena Martinovic / Zgaga, Lina / Skaric-Juric, Tatjana / Wild, Sarah H / Richardson, William A / Hohenstein, Peter / Kimber, Charley H / Tenesa, Albert / Donnelly, Louise A / Fairbanks, Lynette D / Aringer, Martin / McKeigue, Paul M / Ralston, Stuart H / Morris, Andrew D / Rudan, Pavao / Hastie, Nicholas D / Campbell, Harry / Wright, Alan F. ·MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK. ·Nat Genet · Pubmed #18327257.

ABSTRACT: Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200-500 microM) compared with other mammals (3-120 microM). About 70% of daily urate disposal occurs via the kidneys, and in 5-25% of the human population, impaired renal excretion leads to hyperuricemia. About 10% of people with hyperuricemia develop gout, an inflammatory arthritis that results from deposition of monosodium urate crystals in the joint. We have identified genetic variants within a transporter gene, SLC2A9, that explain 1.7-5.3% of the variance in serum uric acid concentrations, following a genome-wide association scan in a Croatian population sample. SLC2A9 variants were also associated with low fractional excretion of uric acid and/or gout in UK, Croatian and German population samples. SLC2A9 is a known fructose transporter, and we now show that it has strong uric acid transport activity in Xenopus laevis oocytes.