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Gout: HELP
Articles by Giovanni Gambaro
Based on 2 articles published since 2008
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Between 2008 and 2019, Giovanni Gambaro wrote the following 2 articles about Gout.
 
+ Citations + Abstracts
1 Article Modulation of genetic associations with serum urate levels by body-mass-index in humans. 2015

Huffman, Jennifer E / Albrecht, Eva / Teumer, Alexander / Mangino, Massimo / Kapur, Karen / Johnson, Toby / Kutalik, Zoltán / Pirastu, Nicola / Pistis, Giorgio / Lopez, Lorna M / Haller, Toomas / Salo, Perttu / Goel, Anuj / Li, Man / Tanaka, Toshiko / Dehghan, Abbas / Ruggiero, Daniela / Malerba, Giovanni / Smith, Albert V / Nolte, Ilja M / Portas, Laura / Phipps-Green, Amanda / Boteva, Lora / Navarro, Pau / Johansson, Asa / Hicks, Andrew A / Polasek, Ozren / Esko, Tõnu / Peden, John F / Harris, Sarah E / Murgia, Federico / Wild, Sarah H / Tenesa, Albert / Tin, Adrienne / Mihailov, Evelin / Grotevendt, Anne / Gislason, Gauti K / Coresh, Josef / D'Adamo, Pio / Ulivi, Sheila / Vollenweider, Peter / Waeber, Gerard / Campbell, Susan / Kolcic, Ivana / Fisher, Krista / Viigimaa, Margus / Metter, Jeffrey E / Masciullo, Corrado / Trabetti, Elisabetta / Bombieri, Cristina / Sorice, Rossella / Döring, Angela / Reischl, Eva / Strauch, Konstantin / Hofman, Albert / Uitterlinden, Andre G / Waldenberger, Melanie / Wichmann, H-Erich / Davies, Gail / Gow, Alan J / Dalbeth, Nicola / Stamp, Lisa / Smit, Johannes H / Kirin, Mirna / Nagaraja, Ramaiah / Nauck, Matthias / Schurmann, Claudia / Budde, Kathrin / Farrington, Susan M / Theodoratou, Evropi / Jula, Antti / Salomaa, Veikko / Sala, Cinzia / Hengstenberg, Christian / Burnier, Michel / Mägi, Reedik / Klopp, Norman / Kloiber, Stefan / Schipf, Sabine / Ripatti, Samuli / Cabras, Stefano / Soranzo, Nicole / Homuth, Georg / Nutile, Teresa / Munroe, Patricia B / Hastie, Nicholas / Campbell, Harry / Rudan, Igor / Cabrera, Claudia / Haley, Chris / Franco, Oscar H / Merriman, Tony R / Gudnason, Vilmundur / Pirastu, Mario / Penninx, Brenda W / Snieder, Harold / Metspalu, Andres / Ciullo, Marina / Pramstaller, Peter P / van Duijn, Cornelia M / Ferrucci, Luigi / Gambaro, Giovanni / Deary, Ian J / Dunlop, Malcolm G / Wilson, James F / Gasparini, Paolo / Gyllensten, Ulf / Spector, Tim D / Wright, Alan F / Hayward, Caroline / Watkins, Hugh / Perola, Markus / Bochud, Murielle / Kao, W H Linda / Caulfield, Mark / Toniolo, Daniela / Völzke, Henry / Gieger, Christian / Köttgen, Anna / Vitart, Veronique. ·Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom. · Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. · Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany. · King's College London, St. Thomas' Hospital Campus, London, United Kingdom. · Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland. · William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom. · Institute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy; University of Trieste, Trieste, Italy. · Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy. · Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom. · Estonian Genome Center, University of Tartu, Tartu, Estonia. · Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland. · Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. · Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. · Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America. · Member of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. · Institute of Genetics and Biophysics "A. Buzzati-Traverso"-Consiglio Nazionale delle Ricerche (CNR), Naples, Italy. · Biology and Genetics section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy. · Icelandic Heart Association Research Institute, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland. · Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. · Institute of Population Genetics, National Research Council of Italy, Sassari, Italy. · Department of Biochemistry, University of Otago, Dunedin, New Zealand. · Uppsala Clinical Research Center, Uppsala University Hospital, Upsalla, Sweden; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden. · Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy; Affiliated Institute of the University of Lübeck, Lübeck, Germany. · Faculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia. · Estonian Genome Center, University of Tartu, Tartu, Estonia; Broad Institute, Cambridge, MA, United States of America; Children's Hospital Boston, Boston, MA, United States of America. · Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom; Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom. · Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom. · Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom; Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom. · Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany. · Icelandic Heart Association Research Institute, Kopavogur, Iceland. · Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, MD, United States of America. · Institute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy. · Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland. · Tallinn University of Technology, Department of Biomedical Engineering, Chair of Medical Physics, Tallinn, Estonia; Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia. · Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. · Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. · Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany. · Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany; Klinikum Grosshadern, Munich, Germany. · Bone and Joint Research Group, Department of Medicine, University of Auckland, Auckland, New Zealand. · Department of Medicine, University of Otago, Christchurch, New Zealand. · Department of Psychiatry/EMGO Institute, VU University Medical Centre, Amsterdam, the Netherlands. · Laboratory of Genetics, National Institute on Aging (NIA), Baltimore, MD, United States of America. · Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Turku, Finland. · University Hospital Regensburg, Regensburg, Germany. · Department of Medicine, Nephrology Division, Lausanne University Hospital, Lausanne, Switzerland. · Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany. · Max Planck Institute of Psychiatry, Munich, Germany. · Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. · Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Turku, Finland; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom; University of Helsinki, Institute of Molecular Medicine, Helsinki, Finland. · Department of Mathematics and Informatics, Università di Cagliari, Cagliari, Italy; Department of Statistics, Universidad Carlos III de Madrid, Madrid, Spain. · Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom. · Faculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia; Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom. · Queen Mary, University of London, London, United Kingdom. · Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Department of Epidemiology, Subdivision Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. · Department of Epidemiology, Subdivision Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands. · Institute of Internal Medicine, Renal Program, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy. · Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden. · on behalf of PROCARDIS; Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. · Estonian Genome Center, University of Tartu, Tartu, Estonia; Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland; University of Helsinki, Institute of Molecular Medicine, Helsinki, Finland. · University Institute of Social and Preventive Medicine, Lausanne, Switzerland. · Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Renal Division, Freiburg University Hospital, Freiburg, Germany. ·PLoS One · Pubmed #25811787.

ABSTRACT: We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, Pinter= 2.6 x 10-8). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDARADD, also displayed suggestive differences in main effect size between the lean and obese strata. All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata. They include the locus RBMS1-TANK (men, Pdifflean-overweight= 4.7 x 10-8), a region that has been associated with several obesity related traits, and TSPYL5 (men, Pdifflean-overweight= 9.1 x 10-8), regulating adipocytes-produced estradiol. The top-ranking known urate loci was ABCG2, the strongest known gout risk locus, with an effect halved in obese compared to lean men (Pdifflean-obese= 2 x 10-4). Finally, pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum. These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment.

2 Article Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 2013

Köttgen, Anna / Albrecht, Eva / Teumer, Alexander / Vitart, Veronique / Krumsiek, Jan / Hundertmark, Claudia / Pistis, Giorgio / Ruggiero, Daniela / O'Seaghdha, Conall M / Haller, Toomas / Yang, Qiong / Tanaka, Toshiko / Johnson, Andrew D / Kutalik, Zoltán / Smith, Albert V / Shi, Julia / Struchalin, Maksim / Middelberg, Rita P S / Brown, Morris J / Gaffo, Angelo L / Pirastu, Nicola / Li, Guo / Hayward, Caroline / Zemunik, Tatijana / Huffman, Jennifer / Yengo, Loic / Zhao, Jing Hua / Demirkan, Ayse / Feitosa, Mary F / Liu, Xuan / Malerba, Giovanni / Lopez, Lorna M / van der Harst, Pim / Li, Xinzhong / Kleber, Marcus E / Hicks, Andrew A / Nolte, Ilja M / Johansson, Asa / Murgia, Federico / Wild, Sarah H / Bakker, Stephan J L / Peden, John F / Dehghan, Abbas / Steri, Maristella / Tenesa, Albert / Lagou, Vasiliki / Salo, Perttu / Mangino, Massimo / Rose, Lynda M / Lehtimäki, Terho / Woodward, Owen M / Okada, Yukinori / Tin, Adrienne / Müller, Christian / Oldmeadow, Christopher / Putku, Margus / Czamara, Darina / Kraft, Peter / Frogheri, Laura / Thun, Gian Andri / Grotevendt, Anne / Gislason, Gauti Kjartan / Harris, Tamara B / Launer, Lenore J / McArdle, Patrick / Shuldiner, Alan R / Boerwinkle, Eric / Coresh, Josef / Schmidt, Helena / Schallert, Michael / Martin, Nicholas G / Montgomery, Grant W / Kubo, Michiaki / Nakamura, Yusuke / Tanaka, Toshihiro / Munroe, Patricia B / Samani, Nilesh J / Jacobs, David R / Liu, Kiang / D'Adamo, Pio / Ulivi, Sheila / Rotter, Jerome I / Psaty, Bruce M / Vollenweider, Peter / Waeber, Gerard / Campbell, Susan / Devuyst, Olivier / Navarro, Pau / Kolcic, Ivana / Hastie, Nicholas / Balkau, Beverley / Froguel, Philippe / Esko, Tõnu / Salumets, Andres / Khaw, Kay Tee / Langenberg, Claudia / Wareham, Nicholas J / Isaacs, Aaron / Kraja, Aldi / Zhang, Qunyuan / Wild, Philipp S / Scott, Rodney J / Holliday, Elizabeth G / Org, Elin / Viigimaa, Margus / Bandinelli, Stefania / Metter, Jeffrey E / Lupo, Antonio / Trabetti, Elisabetta / Sorice, Rossella / Döring, Angela / Lattka, Eva / Strauch, Konstantin / Theis, Fabian / Waldenberger, Melanie / Wichmann, H-Erich / Davies, Gail / Gow, Alan J / Bruinenberg, Marcel / Anonymous4691162 / Stolk, Ronald P / Kooner, Jaspal S / Zhang, Weihua / Winkelmann, Bernhard R / Boehm, Bernhard O / Lucae, Susanne / Penninx, Brenda W / Smit, Johannes H / Curhan, Gary / Mudgal, Poorva / Plenge, Robert M / Portas, Laura / Persico, Ivana / Kirin, Mirna / Wilson, James F / Mateo Leach, Irene / van Gilst, Wiek H / Goel, Anuj / Ongen, Halit / Hofman, Albert / Rivadeneira, Fernando / Uitterlinden, Andre G / Imboden, Medea / von Eckardstein, Arnold / Cucca, Francesco / Nagaraja, Ramaiah / Piras, Maria Grazia / Nauck, Matthias / Schurmann, Claudia / Budde, Kathrin / Ernst, Florian / Farrington, Susan M / Theodoratou, Evropi / Prokopenko, Inga / Stumvoll, Michael / Jula, Antti / Perola, Markus / Salomaa, Veikko / Shin, So-Youn / Spector, Tim D / Sala, Cinzia / Ridker, Paul M / Kähönen, Mika / Viikari, Jorma / Hengstenberg, Christian / Nelson, Christopher P / Anonymous4701162 / Anonymous4711162 / Anonymous4721162 / Anonymous4731162 / Meschia, James F / Nalls, Michael A / Sharma, Pankaj / Singleton, Andrew B / Kamatani, Naoyuki / Zeller, Tanja / Burnier, Michel / Attia, John / Laan, Maris / Klopp, Norman / Hillege, Hans L / Kloiber, Stefan / Choi, Hyon / Pirastu, Mario / Tore, Silvia / Probst-Hensch, Nicole M / Völzke, Henry / Gudnason, Vilmundur / Parsa, Afshin / Schmidt, Reinhold / Whitfield, John B / Fornage, Myriam / Gasparini, Paolo / Siscovick, David S / Polašek, Ozren / Campbell, Harry / Rudan, Igor / Bouatia-Naji, Nabila / Metspalu, Andres / Loos, Ruth J F / van Duijn, Cornelia M / Borecki, Ingrid B / Ferrucci, Luigi / Gambaro, Giovanni / Deary, Ian J / Wolffenbuttel, Bruce H R / Chambers, John C / März, Winfried / Pramstaller, Peter P / Snieder, Harold / Gyllensten, Ulf / Wright, Alan F / Navis, Gerjan / Watkins, Hugh / Witteman, Jacqueline C M / Sanna, Serena / Schipf, Sabine / Dunlop, Malcolm G / Tönjes, Anke / Ripatti, Samuli / Soranzo, Nicole / Toniolo, Daniela / Chasman, Daniel I / Raitakari, Olli / Kao, W H Linda / Ciullo, Marina / Fox, Caroline S / Caulfield, Mark / Bochud, Murielle / Gieger, Christian. ·Renal Division, Freiburg University Hospital, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de ·Nat Genet · Pubmed #23263486.

ABSTRACT: Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.