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Gout: HELP
Articles by Yingjuan He
Based on 3 articles published since 2010
(Why 3 articles?)
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Between 2010 and 2020, Yi He wrote the following 3 articles about Gout.
 
+ Citations + Abstracts
1 Article Pallidifloside D from Smilax riparia enhanced allopurinol effects in hyperuricemia mice. 2015

Hou, Pi-Yong / Mi, Chao / He, Yi / Zhang, Jun / Wang, Shu-Qing / Yu, Fei / Anderson, Samantha / Zhang, Yan-Wen / Wu, Xiao-Hui. ·Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China. · College of Public Health and Communication, Tianjin Medical University, Tianjin 300070, China. · Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA. · Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China. Electronic address: zhangyanwen@tijmu.edu.cn. · Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China; Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA. Electronic address: longhui804@163.com. ·Fitoterapia · Pubmed #26051087.

ABSTRACT: Pallidifloside D, a saponin glycoside constituent from the total saponins of Smilax riparia, had been proved to be effective in hyperuricemic control. Allopurinol is a commonly used medication to treat hyperuricemia and its complications. In this study, we evaluated whether Pallidifloside D could enhance allopurinol's effects by decreasing the serum uric acid level in a hyperuricemic mouse model induced by potassium oxonate. We found that, compared with allopurinol alone, the combination of allopurinol and Pallidifloside D significantly decreased the serum uric acid level and increased the urine uric acid level (both P<0.05), leading to the normalized serum and urine uric acid concentrations. Data on serum, urine creatinine and BUN supported these observations. Our results showed that the synergistic effects of allopurinol combined with Pallidifloside D were linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1. Our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions.

2 Article Anti-hyperuricemia effects of allopurinol are improved by Smilax riparia, a traditional Chinese herbal medicine. 2015

Wu, Xiao-Hui / Wang, Chong-Zhi / Wang, Shu-Qing / Mi, Chao / He, Yi / Zhang, Jun / Zhang, Yan-Wen / Anderson, Samantha / Yuan, Chun-Su. ·Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China; Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA. · Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA. · Tianjin Key Laboratory on Technologies Enabling Development of Clinical, Therapeutics and Diagnostics, College of Pharmacy, Tianjin Medical University, Tianjin 300070, China. · College of Public Health and Communication, Tianjin Medical University, Tianjin 300070, China. · Tang Center for Herbal Medicine Research, University of Chicago, Chicago, IL 60637, USA. Electronic address: cyuan@dacc.uchicago.edu. ·J Ethnopharmacol · Pubmed #25617746.

ABSTRACT: ETHNOPHARMACOLOGICAL RELEVANCE: The roots and rhizomes of Smilax riparia are called "Niu-Wei-Cai" in traditional Chinese medicine (TCM). This botanical has been used in treating the symptoms of gout and other hyperuricemic-related conditions in TCM. Allopurinol is a commonly used medication to treat hyperuricemia and its complications. In this study, we evaluated whether Smilax riparia could enhance allopurinol׳s effects by decreasing the serum uric acid level in a hyperuricemic mouse model induced by potassium oxonate. MATERIALS AND METHODS: We examined the effects of allopurinol (5mg/kg) administration alone or in combination with Smilax riparia saponins (SRS, 500 mg/kg) on the serum uric acid (SUA), serum creatinine (SCr) and blood urea nitrogen (BUN) levels in a hyperuricemic mouse model. The effects of allopurinol alone or those of allopurinol plus SRS on the XOD activities were measured. Western blot analysis was used to measure the levels of mURAT1, mGLUT9 and mOTA1 in the mice. RESULTS: Compared with allopurinol alone, the combination of allopurinol and SRS significantly decreased the serum uric acid level and increased the urine uric acid level (both P<0.05), leading to the normalized serum and urine uric acid concentrations. Data on serum and urine creatinine and BUN supported these observations. The attenuation of hyperuricemia-induced renal dysfunction was linked to the inhibition of both serum and hepatic xanthine oxidase (XOD), the down-regulation of renal mURAT1 and mGLUT9, and the up-regulation of mOAT1. CONCLUSION: The anti-hyperuricemia effects of allopurinol are improved by Smilax riparia co-administration. The results were supported by the measurement of uric acid, creatinine, BUN, XOD, mURAT1, mGLUT9 and mOAT1. Our data may have a potential value in clinical practice in the treatment of gout and other hyperuricemic conditions.

3 Article Determination of purine contents in different parts of pork and beef by high performance liquid chromatography. 2015

Rong, Shengzhong / Zou, Lina / Zhang, Yannan / Zhang, Guangteng / Li, Xiaoxia / Li, Miaojing / Yang, Fenghua / Li, Chunmei / He, Yingjuan / Guan, Hongjun / Guo, Yupeng / Wang, Dong / Cui, Xinyu / Ye, Hongting / Liu, Fenghai / Pan, Hongzhi / Yang, Yuexin. ·The Public Health School, Mudanjiang Medical University, Mudanjiang, China. · The Affiliated Hongqi Hospital, Mudanjiang Medical University, Mudanjiang, China. · The Public Health School, Harbin Medical University, Harbin, China. · The Public Health School, Harbin Medical University, Harbin, China. Electronic address: panhongzhi@163.com. · The Institute of Nutrition and Food Safety, Chinese Centre for Disease Control and Prevention, Beijing, China. Electronic address: yxyang@263.net. ·Food Chem · Pubmed #25306349.

ABSTRACT: Determination of adenine, hypoxanthine, guanine and xanthine in different parts of pork and beef using high performance liquid chromatography was described. Chromatographic separation was carried out on Waters Atlantis T3 column (4.6 mm × 250 mm × 5 μm) with column temperature at 30 °C. The mobile phase contained 99% 10.0 mmol/L ammonium formate solution at pH 3.6 and 1.0% methanol. Chromatography was achieved at a flow rate of 1.0 mL/min and detection wavelength at 254 nm. The results indicated that total purine amounts in pork rump and beef sirloin were higher than those in other parts (P<0.05). The principal purine bases were hypoxanthine and adenine, and hypoxanthine content was the most highest in all samples (P<0.05). As pork rump and beef sirloin contain considerable amounts of total purine and uricogenic purine base, we suggest that excess consumption of them be avoid, whereas pork loin chop and beef rib eye are more suitable for a low-purine diet.