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Gout: HELP
Articles by Lenore J. Launer
Based on 2 articles published since 2009
(Why 2 articles?)
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Between 2009 and 2019, Lenore Launer wrote the following 2 articles about Gout.
 
+ Citations + Abstracts
1 Article Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 2013

Köttgen, Anna / Albrecht, Eva / Teumer, Alexander / Vitart, Veronique / Krumsiek, Jan / Hundertmark, Claudia / Pistis, Giorgio / Ruggiero, Daniela / O'Seaghdha, Conall M / Haller, Toomas / Yang, Qiong / Tanaka, Toshiko / Johnson, Andrew D / Kutalik, Zoltán / Smith, Albert V / Shi, Julia / Struchalin, Maksim / Middelberg, Rita P S / Brown, Morris J / Gaffo, Angelo L / Pirastu, Nicola / Li, Guo / Hayward, Caroline / Zemunik, Tatijana / Huffman, Jennifer / Yengo, Loic / Zhao, Jing Hua / Demirkan, Ayse / Feitosa, Mary F / Liu, Xuan / Malerba, Giovanni / Lopez, Lorna M / van der Harst, Pim / Li, Xinzhong / Kleber, Marcus E / Hicks, Andrew A / Nolte, Ilja M / Johansson, Asa / Murgia, Federico / Wild, Sarah H / Bakker, Stephan J L / Peden, John F / Dehghan, Abbas / Steri, Maristella / Tenesa, Albert / Lagou, Vasiliki / Salo, Perttu / Mangino, Massimo / Rose, Lynda M / Lehtimäki, Terho / Woodward, Owen M / Okada, Yukinori / Tin, Adrienne / Müller, Christian / Oldmeadow, Christopher / Putku, Margus / Czamara, Darina / Kraft, Peter / Frogheri, Laura / Thun, Gian Andri / Grotevendt, Anne / Gislason, Gauti Kjartan / Harris, Tamara B / Launer, Lenore J / McArdle, Patrick / Shuldiner, Alan R / Boerwinkle, Eric / Coresh, Josef / Schmidt, Helena / Schallert, Michael / Martin, Nicholas G / Montgomery, Grant W / Kubo, Michiaki / Nakamura, Yusuke / Tanaka, Toshihiro / Munroe, Patricia B / Samani, Nilesh J / Jacobs, David R / Liu, Kiang / D'Adamo, Pio / Ulivi, Sheila / Rotter, Jerome I / Psaty, Bruce M / Vollenweider, Peter / Waeber, Gerard / Campbell, Susan / Devuyst, Olivier / Navarro, Pau / Kolcic, Ivana / Hastie, Nicholas / Balkau, Beverley / Froguel, Philippe / Esko, Tõnu / Salumets, Andres / Khaw, Kay Tee / Langenberg, Claudia / Wareham, Nicholas J / Isaacs, Aaron / Kraja, Aldi / Zhang, Qunyuan / Wild, Philipp S / Scott, Rodney J / Holliday, Elizabeth G / Org, Elin / Viigimaa, Margus / Bandinelli, Stefania / Metter, Jeffrey E / Lupo, Antonio / Trabetti, Elisabetta / Sorice, Rossella / Döring, Angela / Lattka, Eva / Strauch, Konstantin / Theis, Fabian / Waldenberger, Melanie / Wichmann, H-Erich / Davies, Gail / Gow, Alan J / Bruinenberg, Marcel / Anonymous4691162 / Stolk, Ronald P / Kooner, Jaspal S / Zhang, Weihua / Winkelmann, Bernhard R / Boehm, Bernhard O / Lucae, Susanne / Penninx, Brenda W / Smit, Johannes H / Curhan, Gary / Mudgal, Poorva / Plenge, Robert M / Portas, Laura / Persico, Ivana / Kirin, Mirna / Wilson, James F / Mateo Leach, Irene / van Gilst, Wiek H / Goel, Anuj / Ongen, Halit / Hofman, Albert / Rivadeneira, Fernando / Uitterlinden, Andre G / Imboden, Medea / von Eckardstein, Arnold / Cucca, Francesco / Nagaraja, Ramaiah / Piras, Maria Grazia / Nauck, Matthias / Schurmann, Claudia / Budde, Kathrin / Ernst, Florian / Farrington, Susan M / Theodoratou, Evropi / Prokopenko, Inga / Stumvoll, Michael / Jula, Antti / Perola, Markus / Salomaa, Veikko / Shin, So-Youn / Spector, Tim D / Sala, Cinzia / Ridker, Paul M / Kähönen, Mika / Viikari, Jorma / Hengstenberg, Christian / Nelson, Christopher P / Anonymous4701162 / Anonymous4711162 / Anonymous4721162 / Anonymous4731162 / Meschia, James F / Nalls, Michael A / Sharma, Pankaj / Singleton, Andrew B / Kamatani, Naoyuki / Zeller, Tanja / Burnier, Michel / Attia, John / Laan, Maris / Klopp, Norman / Hillege, Hans L / Kloiber, Stefan / Choi, Hyon / Pirastu, Mario / Tore, Silvia / Probst-Hensch, Nicole M / Völzke, Henry / Gudnason, Vilmundur / Parsa, Afshin / Schmidt, Reinhold / Whitfield, John B / Fornage, Myriam / Gasparini, Paolo / Siscovick, David S / Polašek, Ozren / Campbell, Harry / Rudan, Igor / Bouatia-Naji, Nabila / Metspalu, Andres / Loos, Ruth J F / van Duijn, Cornelia M / Borecki, Ingrid B / Ferrucci, Luigi / Gambaro, Giovanni / Deary, Ian J / Wolffenbuttel, Bruce H R / Chambers, John C / März, Winfried / Pramstaller, Peter P / Snieder, Harold / Gyllensten, Ulf / Wright, Alan F / Navis, Gerjan / Watkins, Hugh / Witteman, Jacqueline C M / Sanna, Serena / Schipf, Sabine / Dunlop, Malcolm G / Tönjes, Anke / Ripatti, Samuli / Soranzo, Nicole / Toniolo, Daniela / Chasman, Daniel I / Raitakari, Olli / Kao, W H Linda / Ciullo, Marina / Fox, Caroline S / Caulfield, Mark / Bochud, Murielle / Gieger, Christian. ·Renal Division, Freiburg University Hospital, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de ·Nat Genet · Pubmed #23263486.

ABSTRACT: Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.

2 Article Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. 2010

Yang, Qiong / Köttgen, Anna / Dehghan, Abbas / Smith, Albert V / Glazer, Nicole L / Chen, Ming-Huei / Chasman, Daniel I / Aspelund, Thor / Eiriksdottir, Gudny / Harris, Tamara B / Launer, Lenore / Nalls, Michael / Hernandez, Dena / Arking, Dan E / Boerwinkle, Eric / Grove, Megan L / Li, Man / Linda Kao, W H / Chonchol, Michel / Haritunians, Talin / Li, Guo / Lumley, Thomas / Psaty, Bruce M / Shlipak, Michael / Hwang, Shih-Jen / Larson, Martin G / O'Donnell, Christopher J / Upadhyay, Ashish / van Duijn, Cornelia M / Hofman, Albert / Rivadeneira, Fernando / Stricker, Bruno / Uitterlinden, Andre G / Paré, Guillaume / Parker, Alex N / Ridker, Paul M / Siscovick, David S / Gudnason, Vilmundur / Witteman, Jacqueline C / Fox, Caroline S / Coresh, Josef. ·Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. ·Circ Cardiovasc Genet · Pubmed #20884846.

ABSTRACT: BACKGROUND: Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors. We performed a genome-wide association study to search for genetic susceptibility loci for serum urate and gout and investigated the causal nature of the associations of serum urate with gout and selected cardiovascular risk factors and coronary heart disease (CHD). METHODS AND RESULTS: Meta-analyses of genome-wide association studies (GWAS) were performed in 5 population-based cohorts of the Cohorts for Heart and Aging Research in Genome Epidemiology consortium for serum urate and gout in 28 283 white participants. The effect of the most significant single-nucleotide polymorphism at all genome-wide significant loci on serum urate was added to create a genetic urate score. Findings were replicated in the Women's Genome Health Study (n=22 054). Single-nucleotide polymorphisms at 8 genetic loci achieved genome-wide significance with serum urate levels (P=4×10(-8) to 2×10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1). Only 2 loci (SLC2A9, ABCG2) showed genome-wide significant association with gout. The genetic urate score was strongly associated with serum urate and gout (odds ratio, 12.4 per 100 μmol/L; P=3×10(-39)) but not with blood pressure, glucose, estimated glomerular filtration rate, chronic kidney disease, or CHD. The lack of association between the genetic score and the latter phenotypes also was observed in the Women's Genome Health Study. CONCLUSIONS: The genetic urate score analysis suggested a causal relationship between serum urate and gout but did not provide evidence for one between serum urate and cardiovascular risk factors and CHD.