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Gout: HELP
Articles by Paul M. McKeigue
Based on 1 article published since 2008

Between 2008 and 2019, Paul M. McKeigue wrote the following article about Gout.
+ Citations + Abstracts
1 Article SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. 2008

Vitart, Veronique / Rudan, Igor / Hayward, Caroline / Gray, Nicola K / Floyd, James / Palmer, Colin N A / Knott, Sara A / Kolcic, Ivana / Polasek, Ozren / Graessler, Juergen / Wilson, James F / Marinaki, Anthony / Riches, Philip L / Shu, Xinhua / Janicijevic, Branka / Smolej-Narancic, Nina / Gorgoni, Barbara / Morgan, Joanne / Campbell, Susan / Biloglav, Zrinka / Barac-Lauc, Lovorka / Pericic, Marijana / Klaric, Irena Martinovic / Zgaga, Lina / Skaric-Juric, Tatjana / Wild, Sarah H / Richardson, William A / Hohenstein, Peter / Kimber, Charley H / Tenesa, Albert / Donnelly, Louise A / Fairbanks, Lynette D / Aringer, Martin / McKeigue, Paul M / Ralston, Stuart H / Morris, Andrew D / Rudan, Pavao / Hastie, Nicholas D / Campbell, Harry / Wright, Alan F. ·MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK. ·Nat Genet · Pubmed #18327257.

ABSTRACT: Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200-500 microM) compared with other mammals (3-120 microM). About 70% of daily urate disposal occurs via the kidneys, and in 5-25% of the human population, impaired renal excretion leads to hyperuricemia. About 10% of people with hyperuricemia develop gout, an inflammatory arthritis that results from deposition of monosodium urate crystals in the joint. We have identified genetic variants within a transporter gene, SLC2A9, that explain 1.7-5.3% of the variance in serum uric acid concentrations, following a genome-wide association scan in a Croatian population sample. SLC2A9 variants were also associated with low fractional excretion of uric acid and/or gout in UK, Croatian and German population samples. SLC2A9 is a known fructose transporter, and we now show that it has strong uric acid transport activity in Xenopus laevis oocytes.