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Gout: HELP
Articles by Cynthia Sung
Based on 2 articles published since 2010
(Why 2 articles?)

Between 2010 and 2020, Cynthia Sung wrote the following 2 articles about Gout.
+ Citations + Abstracts
1 Article Is HLA-B*58:01 genotyping cost effective in guiding allopurinol use in gout patients with chronic kidney disease? 2020

Teng, Gim Gee / Tan-Koi, Wei-Chuen / Dong, Di / Sung, Cynthia. ·Division of Rheumatology, University Medicine Cluster, National University Health System, Singapore, 119228. · Chronic Program, Alexandra Hospital, National University Health System, Singapore, 159964. · Vigilance & Compliance Branch, Health Sciences Authority, Singapore, 138667. · Global Health Research Center, Duke Kunshan University, China, 215316. · Health Services & Systems Research, Duke-NUS Medical School, Singapore, 169857. ·Pharmacogenomics · Pubmed #32180492.


2 Article Cost-effectiveness analysis of genotyping for HLA-B*5801 and an enhanced safety program in gout patients starting allopurinol in Singapore. 2015

Dong, Di / Tan-Koi, Wei-Chuen / Teng, Gim Gee / Finkelstein, Eric / Sung, Cynthia. ·Health Services & Systems Research Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore. · Vigilance & Compliance Branch, Health Sciences Authority, 11 Biopolis Way, #11-01, Helios, Singapore 138667, Singapore. · Saw Swee Hock School of Public Health, National University of Singapore, Tahir Foundation Building, 12 Science Drive 2, #10-01, Singapore 117549, Singapore. · Division of Rheumatology, National University Health System, University Medicine Cluster, Singapore. · Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore. · Emerging Infectious Diseases Program, Duke-NUS Graduate Medical School, 8 College Road, Singapore 169857, Singapore. ·Pharmacogenomics · Pubmed #26554739.

ABSTRACT: AIMS: Allopurinol is an efficacious urate-lowering therapy (ULT), but is associated with rare serious adverse drug reactions of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN), with higher risk among HLA-B*5801 carriers. We assessed the cost-effectiveness of HLA-B*5801 testing, an enhanced safety program or strategies with both components. METHODS: The analysis adopted a health systems perspective and considered Singaporean patients with chronic gout, over a lifetime horizon, using allopurinol or probenecid. The model incorporated SJS/TEN and gout treatment outcomes, allele frequencies, drug prices and other medical costs. RESULTS: Based on cost-effectiveness threshold of US$50,000 per quality-adjusted life year, HLA-B*5801-guided ULT selection or enhanced safety program was not cost effective. Avoidance of ULTs was the least preferred strategy as uncontrolled gout leads to lower quality-adjusted life years and higher costs. CONCLUSION: The analysis underscores the need for biomarkers with higher positive predictive value for SJS/TEN, less expensive genetic tests or safety programs, or more effective gout drugs. .