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Gout: HELP
Articles by Andre G. Uitterlinden
Based on 4 articles published since 2010
(Why 4 articles?)
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Between 2010 and 2020, André G. Uitterlinden wrote the following 4 articles about Gout.
 
+ Citations + Abstracts
1 Article Target genes, variants, tissues and transcriptional pathways influencing human serum urate levels. 2019

Tin, Adrienne / Marten, Jonathan / Halperin Kuhns, Victoria L / Li, Yong / Wuttke, Matthias / Kirsten, Holger / Sieber, Karsten B / Qiu, Chengxiang / Gorski, Mathias / Yu, Zhi / Giri, Ayush / Sveinbjornsson, Gardar / Li, Man / Chu, Audrey Y / Hoppmann, Anselm / O'Connor, Luke J / Prins, Bram / Nutile, Teresa / Noce, Damia / Akiyama, Masato / Cocca, Massimiliano / Ghasemi, Sahar / van der Most, Peter J / Horn, Katrin / Xu, Yizhe / Fuchsberger, Christian / Sedaghat, Sanaz / Afaq, Saima / Amin, Najaf / Ärnlöv, Johan / Bakker, Stephan J L / Bansal, Nisha / Baptista, Daniela / Bergmann, Sven / Biggs, Mary L / Biino, Ginevra / Boerwinkle, Eric / Bottinger, Erwin P / Boutin, Thibaud S / Brumat, Marco / Burkhardt, Ralph / Campana, Eric / Campbell, Archie / Campbell, Harry / Carroll, Robert J / Catamo, Eulalia / Chambers, John C / Ciullo, Marina / Concas, Maria Pina / Coresh, Josef / Corre, Tanguy / Cusi, Daniele / Felicita, Sala Cinzia / de Borst, Martin H / De Grandi, Alessandro / de Mutsert, Renée / de Vries, Aiko P J / Delgado, Graciela / Demirkan, Ayşe / Devuyst, Olivier / Dittrich, Katalin / Eckardt, Kai-Uwe / Ehret, Georg / Endlich, Karlhans / Evans, Michele K / Gansevoort, Ron T / Gasparini, Paolo / Giedraitis, Vilmantas / Gieger, Christian / Girotto, Giorgia / Gögele, Martin / Gordon, Scott D / Gudbjartsson, Daniel F / Gudnason, Vilmundur / Anonymous3221150 / Haller, Toomas / Hamet, Pavel / Harris, Tamara B / Hayward, Caroline / Hicks, Andrew A / Hofer, Edith / Holm, Hilma / Huang, Wei / Hutri-Kähönen, Nina / Hwang, Shih-Jen / Ikram, M Arfan / Lewis, Raychel M / Ingelsson, Erik / Jakobsdottir, Johanna / Jonsdottir, Ingileif / Jonsson, Helgi / Joshi, Peter K / Josyula, Navya Shilpa / Jung, Bettina / Kähönen, Mika / Kamatani, Yoichiro / Kanai, Masahiro / Kerr, Shona M / Kiess, Wieland / Kleber, Marcus E / Koenig, Wolfgang / Kooner, Jaspal S / Körner, Antje / Kovacs, Peter / Krämer, Bernhard K / Kronenberg, Florian / Kubo, Michiaki / Kühnel, Brigitte / La Bianca, Martina / Lange, Leslie A / Lehne, Benjamin / Lehtimäki, Terho / Anonymous3231150 / Liu, Jun / Loeffler, Markus / Loos, Ruth J F / Lyytikäinen, Leo-Pekka / Magi, Reedik / Mahajan, Anubha / Martin, Nicholas G / März, Winfried / Mascalzoni, Deborah / Matsuda, Koichi / Meisinger, Christa / Meitinger, Thomas / Metspalu, Andres / Milaneschi, Yuri / Anonymous3241150 / O'Donnell, Christopher J / Wilson, Otis D / Gaziano, J Michael / Mishra, Pashupati P / Mohlke, Karen L / Mononen, Nina / Montgomery, Grant W / Mook-Kanamori, Dennis O / Müller-Nurasyid, Martina / Nadkarni, Girish N / Nalls, Mike A / Nauck, Matthias / Nikus, Kjell / Ning, Boting / Nolte, Ilja M / Noordam, Raymond / O'Connell, Jeffrey R / Olafsson, Isleifur / Padmanabhan, Sandosh / Penninx, Brenda W J H / Perls, Thomas / Peters, Annette / Pirastu, Mario / Pirastu, Nicola / Pistis, Giorgio / Polasek, Ozren / Ponte, Belen / Porteous, David J / Poulain, Tanja / Preuss, Michael H / Rabelink, Ton J / Raffield, Laura M / Raitakari, Olli T / Rettig, Rainer / Rheinberger, Myriam / Rice, Kenneth M / Rizzi, Federica / Robino, Antonietta / Rudan, Igor / Krajcoviechova, Alena / Cifkova, Renata / Rueedi, Rico / Ruggiero, Daniela / Ryan, Kathleen A / Saba, Yasaman / Salvi, Erika / Schmidt, Helena / Schmidt, Reinhold / Shaffer, Christian M / Smith, Albert V / Smith, Blair H / Spracklen, Cassandra N / Strauch, Konstantin / Stumvoll, Michael / Sulem, Patrick / Tajuddin, Salman M / Teren, Andrej / Thiery, Joachim / Thio, Chris H L / Thorsteinsdottir, Unnur / Toniolo, Daniela / Tönjes, Anke / Tremblay, Johanne / Uitterlinden, André G / Vaccargiu, Simona / van der Harst, Pim / van Duijn, Cornelia M / Verweij, Niek / Völker, Uwe / Vollenweider, Peter / Waeber, Gerard / Waldenberger, Melanie / Whitfield, John B / Wild, Sarah H / Wilson, James F / Yang, Qiong / Zhang, Weihua / Zonderman, Alan B / Bochud, Murielle / Wilson, James G / Pendergrass, Sarah A / Ho, Kevin / Parsa, Afshin / Pramstaller, Peter P / Psaty, Bruce M / Böger, Carsten A / Snieder, Harold / Butterworth, Adam S / Okada, Yukinori / Edwards, Todd L / Stefansson, Kari / Susztak, Katalin / Scholz, Markus / Heid, Iris M / Hung, Adriana M / Teumer, Alexander / Pattaro, Cristian / Woodward, Owen M / Vitart, Veronique / Köttgen, Anna. ·Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. atin1@jhu.edu. · Welch Centre for Prevention, Epidemiology and Clinical Research, Baltimore, MD, USA. atin1@jhu.edu. · Medical Research Council Human Genetics Unit, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. · Department of Physiology, University of Maryland School of Medicine, Baltimore, MD, USA. · Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. · Institute for Medical Informatics, Statistics and Epidemiology, University of Leipzig, Leipzig, Germany. · LIFE Research Centre for Civilization Diseases, University of Leipzig, Leipzig, Germany. · Target Sciences-Genetics, GlaxoSmithKline, Collegeville, PA, USA. · Department of Medicine and Genetics, University of Pennsylvania, Philadelphia, PA, USA. · Department of Nephrology, University Hospital Regensburg, Regensburg, Germany. · Department of Genetic Epidemiology, University of Regensburg, Regensburg, Germany. · Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. · Department of Biostatistics, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. · Division of Quantitative Sciences, Department of Obstetrics & Gynecology, Vanderbilt Genetics Institute, Vanderbilt Epidemiology Center, Institute for Medicine and Public Health, Vanderbilt University Medical Center, Nashville, TN, USA. · Biomedical Laboratory Research and Development, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. · deCODE Genetics, Amgen Inc., Reykjavik, Iceland. · Department of Medicine, Division of Nephrology and Hypertension, University of Utah, Salt Lake City, UT, USA. · Genetics, Merck & Co., Inc, Kenilworth, NJ, USA. · Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. · Strangeways Research Laboratory, University of Cambridge, Cambridge, UK. · Institute of Genetics and Biophysics Adriano Buzzati-Traverso-CNR, Naples, Italy. · Eurac Research, Institute for Biomedicine, Bolzano, Italy. · Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Yokohama (Kanagawa), Japan. · Department of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan. · Institute for Maternal and Child Health-IRCCS Burlo Garofolo, Trieste, Italy. · Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. · DZHK (German Center for Cardiovascular Research), Partner Site Greifswald, Greifswald, Germany. · Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. · Department of Epidemiology, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. · Department of Epidemiology and Biostatistics, Faculty of Medicine, School of Public Health, Imperial College London, London, UK. · Institute of Public Health & Social Sciences, Khyber Medical University, Peshawar, Pakistan. · Department of Neurobiology, Care Sciences and Society, Division of Family Medicine and Primary Care, Karolinska Institutet, Stockholm, Sweden. · School of Health and Social Studies, Dalarna University, Falun, Sweden. · Department of Internal Medicine, Division of Nephrology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. · Division of Nephrology, University of Washington, Seattle, WA, USA. · Kidney Research Institute, University of Washington, Seattle, WA, USA. · Cardiology, Geneva University Hospitals, Geneva, Switzerland. · Department of Computational Biology, University of Lausanne, Lausanne, Switzerland. · Swiss Institute of Bioinformatics, Lausanne, Switzerland. · Department of Integrative Biomedical Sciences, University of Cape Town, Cape Town, South Africa. · Cardiovascular Health Research Unit, Department of Medicine, University of Washington, Seattle, WA, USA. · Department of Biostatistics, University of Washington, Seattle, WA, USA. · Institute of Molecular Genetics, National Research Council of Italy, Pavia, Italy. · Human Genetics Centre, University of Texas Health Science Centre, Houston, TX, USA. · Hasso Plattner Institute for Digital Health at Mount Sinai, Icahn School of Medicine at Mount Sinai, New York, NY, USA. · University of Trieste, Department of Medicine, Surgery and Health Sciences, Trieste, Italy. · Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany. · Institute of Clinical Chemistry and Laboratory Medicine, University Hospital Regensburg, Regensburg, Germany. · Centre for Genomic and Experimental Medicine, Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh, UK. · Centre for Global Health Research, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. · Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, TN, USA. · Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore, Singapore. · Department of Cardiology, Ealing Hospital, London, UK. · Imperial College Healthcare NHS Trust, Imperial College London, London, UK. · MRC-PHE Centre for Environment and Health, School of Public Health, Imperial College London, London, UK. · IRCCS Neuromed, Pozzilli, Italy. · Center for Primary Care and Public Health (Unisanté), University of Lausanne, Lausanne, Switzerland. · Institute of Biomedical Technologies, Italy National Research Council, Milano, Italy. · Bio4Dreams, Milano, Italy. · San Raffaele Research Institute, Milano, Italy. · Department of Clinical Epidemiology, Leiden University Medical Centre, Leiden, the Netherlands. · Section of Nephrology, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands. · Fifth Department of Medicine (Nephrology, Hypertensiology, Rheumatology, Endocrinology, Diabetology), Medical Faculty Mannheim, University of Heidelberg, Mannheim, Germany. · Department of Genetics, University Medical Center Groningen, Groningen, the Netherlands. · Institute of Physiology, University of Zurich, Zurich, Switzerland. · Department of Women and Child Health, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany. · Centre for Pediatric Research, University of Leipzig, Leipzig, Germany. · Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany. · Department of Nephrology and Hypertension, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany. · Department of Anatomy and Cell Biology, University Medicine Greifswald, Greifswald, Germany. · Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Baltimore, MD, USA. · Department of Public Health and Caring Sciences, Molecular Geriatrics, Uppsala University, Uppsala, Sweden. · Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany. · Institute of Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany. · German Center for Diabetes Research, Neuherberg, Germany. · QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia. · Icelandic Heart Association, Kópavogur, Iceland. · Faculty of Medicine, School of Health Sciences, University of Iceland, Reykjavik, Iceland. · Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. · Montreal University Hospital Research Centre, Centre Hospitalier de lUniversité de Montréal, Montreal, Quebec, Canada. · Medpharmgene, Montreal, Quebec, Canada. · Laboratory of Epidemiology and Population Sciences, National Institute on Aging, Intramural Research Program, National Institutes of Health, Bethesda, MD, USA. · Clinical Division of Neurogeriatrics, Department of Neurology, Medical University of Graz, Graz, Austria. · Institute for Medical Informatics, Statistics and Documentation, Medical University of Graz, Graz, Austria. · Department of Genetics, Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Centre, Shanghai, China. · Shanghai Industrial Technology Institute, Shanghai, China. · Department of Clinical Chemistry, Fimlab Laboratories, and Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. · Department of Pediatrics, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. · National Heart, Lung, and Blood Institute Framingham Heart Study, Framingham, MA, USA. · The Centre for Population Studies, National Heart, Lung, and Blood Institute, Framingham, MA, USA. · Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA. · Stanford Cardiovascular Institute, Stanford University, Stanford, CA, USA. · Molecular Epidemiology and Science for Life Laboratory, Department of Medical Sciences, Uppsala University, Uppsala, Sweden. · Stanford Diabetes Research Center, Stanford University, Stanford, CA, USA. · The Centre of Public Health Sciences, University of Iceland, Reykjavik, Iceland. · Landspitalinn University Hospital, Reykjavík, Iceland. · University of Iceland, Reykjavík, Iceland. · Geisinger Research, Biomedical and Translational Informatics Institute, Rockville, MD, USA. · Department of Clinical Physiology, Tampere University Hospital, and Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. · Kyoto-McGill International Collaborative School in Genomic Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan. · Department of Biomedical Informatics, Harvard Medical School, Boston, MA, USA. · Deutsches Herzzentrum München, Technische Universität München, Munich, Germany. · German Centre for Cardiovascular Research, Partner Site Munich Heart Alliance, Munich, Germany. · Institute of Epidemiology and Biostatistics, University of Ulm, Ulm, Germany. · MRC-PHE Centre for Environment and Health, 323 School of Public Health, Imperial College London, London, UK. · National Heart and Lung Institute, Imperial College London, London, UK. · Integrated Research and Treatment Centre Adiposity Diseases, University of Leipzig, Leipzig, Germany. · Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Medical University of Innsbruck, Innsbruck, Austria. · RIKEN Centre for Integrative Medical Sciences, Yokohama (Kanagawa), Japan. · Division of Biomedical Informatics and Personalized Medicine, School of Medicine, University of Colorado Denver-Anschutz Medical Campus, Aurora, CO, USA. · Nuffield Department of Population Health, University of Oxford, Oxford, UK. · The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. · The Mindich Child Health and Development Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. · Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK. · Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. · Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany. · Clinical Institute of Medical and Chemical Laboratory Diagnostics, Medical University of Graz, Graz, Austria. · Laboratory of Clinical Genome Sequencing, Graduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan. · Independent Research Group Clinical Epidemiology, Helmholtz Zentrum München, German Research Centre for Environmental Health, Neuherberg, Germany. · Ludwig-Maximilians-Universität München at UNIKA-T Augsburg, Augsburg, Germany. · Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany. · Institute of Human Genetics, Technische Universität München, Munich, Germany. · Department of Psychiatry, Amsterdam Neuroscience and Amsterdam Public Health Research Institute, Amsterdam University Medical Centers, Amsterdam, the Netherlands. · VA Boston Healthcare System, Boston, MA, USA. · Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA. · Vanderbilt University Medical Centre, Division of Nephrology & Hypertension, Nashville, TN, USA. · Massachusetts Veterans Epidemiology Research and Information Center, VA Cooperative Studies Program, VA Boston Healthcare System, Boston, MA, USA. · Department of Genetics, University of North Carolina, Chapel Hill, NC, USA. · University of Queensland, St Lucia, Queensland, Australia. · Department of Public Health and Primary Care, Leiden University Medical Centre, Leiden, the Netherlands. · Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Centre for Environmental Health, Neuherberg, Germany. · Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich, Germany. · Department of Internal Medicine I (Cardiology), Hospital of the Ludwig-Maximilians-University Munich, Munich, Germany. · Division of Nephrology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. · Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. · Data Tecnica International, Glen Echo, MD, USA. · Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Greifswald, Germany. · Department of Cardiology, Heart Center, Tampere University Hospital, Tampere, Finland. · Department of Cardiology, Finnish Cardiovascular Research Center-Tampere, Faculty of Medicine and Health Technology, Tampere University, Tampere, Finland. · Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. · Section of Gerontology and Geriatrics, Department of Internal Medicine, Leiden University Medical Centre, Leiden, the Netherlands. · University of Maryland School of Medicine, Baltimore, MD, USA. · Department of Clinical Biochemistry, Landspitali University Hospital, Reykjavik, Iceland. · Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK. · Department of Medicine, Geriatrics Section, Boston Medical Center, Boston University School of Medicine, Boston, MA, USA. · Institute of Genetic and Biomedical Research, National Research Council of Italy, UOS of Sassari, Sassari, Italy. · Department of Psychiatry, University Hospital of Lausanne, Lausanne, Switzerland. · Faculty of Medicine, University of Split, Split, Croatia. · Gen-info Ltd, Zagreb, Croatia. · Nephrology Service, Department of Specialties in Internal Medicine, University Hospitals of Geneva, Geneva, Switzerland. · Centre for Cognitive Ageing and Cognitive Epidemiology, University of Edinburgh, Edinburgh, UK. · Einthoven Laboratory of Experimental Vascular Research, Leiden University Medical Centre, Leiden, the Netherlands. · Department of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku, Finland. · Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland. · Centre for Population Health Research, University of Turku and Turku University Hospital, Turku, Finland. · Institute of Physiology, University Medicine Greifswald, Karlsburg, Germany. · Department of Health Sciences, University of Milan, Milano, Italy. · ePhood Scientific Unit, ePhood SRL, Milano, Italy. · Center for Cardiovascular Prevention, First Faculty of Medicine, Charles University and Thomayer Hospital, Prague, Czech Republic. · Thomayer Hospital, Prague, Czech Republic. · Department of Medicine II, First Faculty of Medicine, Charles University, Prague, Czech Republic. · Division of Endocrinology, Diabetes and Nutrition, University of Maryland School of Medicine, Baltimore, MD, USA. · Molecular Biology and Biochemistry, Gottfried Schatz Research Centre for Cell Signaling, Metabolism and Aging, Medical University of Graz, Graz, Austria. · Neurology Unit, Fondazione IRCCS Istituto Neurologico Carlo Besta, Milan, Italy. · Institute of Molecular Biology and Biochemistry, Centre for Molecular Medicine, Medical University of Graz, Graz, Austria. · Division of Population Health and Genomics, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. · Division of Endocrinology, Nephrology and Rheumatology, University of Leipzig, Leipzig, Germany. · Heart Centre Leipzig, Leipzig, Germany. · Department of Endocrinology and Nephrology, University of Leipzig, Leipzig, Germany. · Centre de Recherche du CHUM, Montreal, Quebec, Canada. · Department of Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, the Netherlands. · Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. · Department of Genetics, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. · Durrer Centre for Cardiovascular Research, the Netherlands Heart Institute, Utrecht, the Netherlands. · Leiden Academic Centre for Drug Research, Leiden University, Leiden, the Netherlands. · Genomics plc, Oxford, UK. · Interfaculty Institute for Genetics and Functional Genomics, University Medicine Greifswald, Greifswald, Germany. · Internal Medicine, Department of Medicine, Lausanne University Hospital, Lausanne, Switzerland. · Centre for Population Health Sciences, Usher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, UK. · Department of Physiology and Biophysics, University of Mississippi Medical Centre, Jackson, MS, USA. · Geisinger Research, Biomedical and Translational Informatics Institute, Danville, PA, USA. · Kidney Health Research Institute, Geisinger, Danville, PA, USA. · Department of Nephrology, Geisinger, Danville, PA, USA. · Division of Kidney, Urologic and Hematologic Diseases, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. · Department of Medicine, University of Maryland School of Medicine, Baltimore, MD, USA. · Cardiovascular Health Research Unit, Department of Medicine, Department of Epidemiology, Department of Health Service, University of Washington, Seattle, WA, USA. · Kaiser Permanente Washington Health Research Institute, Seattle, WA, USA. · Department of Nephrology and Rheumatology, Kliniken Südostbayern AG, Traunstein, Germany. · Department of Public Health and Primary Care, University of Cambridge, Cambridge, UK. · Laboratory for Statistical Analysis, RIKEN Centre for Integrative Medical Sciences, Osaka, Japan. · Department of Statistical Genetics, Osaka University Graduate School of Medicine, Osaka, Japan. · Division of Epidemiology, Department of Medicine, Vanderbilt Genetics Institute, Vanderbilt University Medical Centre, Nashville, TN, USA. · Department of Veterans Affairs, Tennessee Valley Healthcare System (626)/Vanderbilt University, Nashville, TN, USA. · Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA. anna.koettgen@uniklinik-freiburg.de. · Institute of Genetic Epidemiology, Department of Biometry, Epidemiology and Medical Bioinformatics, Faculty of Medicine and Medical Center-University of Freiburg, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de. ·Nat Genet · Pubmed #31578528.

ABSTRACT: Elevated serum urate levels cause gout and correlate with cardiometabolic diseases via poorly understood mechanisms. We performed a trans-ancestry genome-wide association study of serum urate in 457,690 individuals, identifying 183 loci (147 previously unknown) that improve the prediction of gout in an independent cohort of 334,880 individuals. Serum urate showed significant genetic correlations with many cardiometabolic traits, with genetic causality analyses supporting a substantial role for pleiotropy. Enrichment analysis, fine-mapping of urate-associated loci and colocalization with gene expression in 47 tissues implicated the kidney and liver as the main target organs and prioritized potentially causal genes and variants, including the transcriptional master regulators in the liver and kidney, HNF1A and HNF4A. Experimental validation showed that HNF4A transactivated the promoter of ABCG2, encoding a major urate transporter, in kidney cells, and that HNF4A p.Thr139Ile is a functional variant. Transcriptional coregulation within and across organs may be a general mechanism underlying the observed pleiotropy between urate and cardiometabolic traits.

2 Article Modulation of genetic associations with serum urate levels by body-mass-index in humans. 2015

Huffman, Jennifer E / Albrecht, Eva / Teumer, Alexander / Mangino, Massimo / Kapur, Karen / Johnson, Toby / Kutalik, Zoltán / Pirastu, Nicola / Pistis, Giorgio / Lopez, Lorna M / Haller, Toomas / Salo, Perttu / Goel, Anuj / Li, Man / Tanaka, Toshiko / Dehghan, Abbas / Ruggiero, Daniela / Malerba, Giovanni / Smith, Albert V / Nolte, Ilja M / Portas, Laura / Phipps-Green, Amanda / Boteva, Lora / Navarro, Pau / Johansson, Asa / Hicks, Andrew A / Polasek, Ozren / Esko, Tõnu / Peden, John F / Harris, Sarah E / Murgia, Federico / Wild, Sarah H / Tenesa, Albert / Tin, Adrienne / Mihailov, Evelin / Grotevendt, Anne / Gislason, Gauti K / Coresh, Josef / D'Adamo, Pio / Ulivi, Sheila / Vollenweider, Peter / Waeber, Gerard / Campbell, Susan / Kolcic, Ivana / Fisher, Krista / Viigimaa, Margus / Metter, Jeffrey E / Masciullo, Corrado / Trabetti, Elisabetta / Bombieri, Cristina / Sorice, Rossella / Döring, Angela / Reischl, Eva / Strauch, Konstantin / Hofman, Albert / Uitterlinden, Andre G / Waldenberger, Melanie / Wichmann, H-Erich / Davies, Gail / Gow, Alan J / Dalbeth, Nicola / Stamp, Lisa / Smit, Johannes H / Kirin, Mirna / Nagaraja, Ramaiah / Nauck, Matthias / Schurmann, Claudia / Budde, Kathrin / Farrington, Susan M / Theodoratou, Evropi / Jula, Antti / Salomaa, Veikko / Sala, Cinzia / Hengstenberg, Christian / Burnier, Michel / Mägi, Reedik / Klopp, Norman / Kloiber, Stefan / Schipf, Sabine / Ripatti, Samuli / Cabras, Stefano / Soranzo, Nicole / Homuth, Georg / Nutile, Teresa / Munroe, Patricia B / Hastie, Nicholas / Campbell, Harry / Rudan, Igor / Cabrera, Claudia / Haley, Chris / Franco, Oscar H / Merriman, Tony R / Gudnason, Vilmundur / Pirastu, Mario / Penninx, Brenda W / Snieder, Harold / Metspalu, Andres / Ciullo, Marina / Pramstaller, Peter P / van Duijn, Cornelia M / Ferrucci, Luigi / Gambaro, Giovanni / Deary, Ian J / Dunlop, Malcolm G / Wilson, James F / Gasparini, Paolo / Gyllensten, Ulf / Spector, Tim D / Wright, Alan F / Hayward, Caroline / Watkins, Hugh / Perola, Markus / Bochud, Murielle / Kao, W H Linda / Caulfield, Mark / Toniolo, Daniela / Völzke, Henry / Gieger, Christian / Köttgen, Anna / Vitart, Veronique. ·Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom. · Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. · Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany. · King's College London, St. Thomas' Hospital Campus, London, United Kingdom. · Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland; Swiss Institute of Bioinformatics, Lausanne, Switzerland. · William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, United Kingdom. · Institute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy; University of Trieste, Trieste, Italy. · Division of Genetics and Cell Biology, San Raffaele Scientific Institute, Milano, Italy. · Department of Psychology, The University of Edinburgh, Edinburgh, United Kingdom; Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom. · Estonian Genome Center, University of Tartu, Tartu, Estonia. · Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland. · Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. · Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America. · Clinical Research Branch, National Institute on Aging, Baltimore, MD, United States of America. · Member of Netherlands Consortium for Healthy Aging (NCHA) sponsored by Netherlands Genomics Initiative (NGI), Leiden, The Netherlands; Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands. · Institute of Genetics and Biophysics "A. Buzzati-Traverso"-Consiglio Nazionale delle Ricerche (CNR), Naples, Italy. · Biology and Genetics section, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy. · Icelandic Heart Association Research Institute, Kopavogur, Iceland; University of Iceland, Reykjavik, Iceland. · Department of Epidemiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands. · Institute of Population Genetics, National Research Council of Italy, Sassari, Italy. · Department of Biochemistry, University of Otago, Dunedin, New Zealand. · Uppsala Clinical Research Center, Uppsala University Hospital, Upsalla, Sweden; Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden. · Center for Biomedicine, European Academy Bozen/Bolzano (EURAC), Bolzano, Italy; Affiliated Institute of the University of Lübeck, Lübeck, Germany. · Faculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia. · Estonian Genome Center, University of Tartu, Tartu, Estonia; Broad Institute, Cambridge, MA, United States of America; Children's Hospital Boston, Boston, MA, United States of America. · Centre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh, United Kingdom; Medical Genetics Section, University of Edinburgh Centre for Genomics and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, Edinburgh, United Kingdom. · Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom. · Medical Research Council (MRC) Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine (IGMM), University of Edinburgh, Edinburgh, United Kingdom; Roslin Institute, The University of Edinburgh, Edinburgh, United Kingdom. · Institute of Clinical Chemistry and Laboratory Medicine, University Medicine Greifswald, Ernst-Moritz-Arndt University Greifswald, Greifswald, Germany. · Icelandic Heart Association Research Institute, Kopavogur, Iceland. · Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Welch Center for Prevention, Epidemiology and Clinical Research, John Hopkins University, Baltimore, MD, United States of America. · Institute for Maternal and Child Health-Istituto Di Ricovero e Cura a Carattere Scientifico (IRCCS) "Burlo Garofolo", Trieste, Italy. · Department of Medicine, Internal Medicine, Lausanne University Hospital, Lausanne, Switzerland. · Tallinn University of Technology, Department of Biomedical Engineering, Chair of Medical Physics, Tallinn, Estonia; Centre of Cardiology, North Estonia Medical Centre, Tallinn, Estonia. · Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. · Institute of Epidemiology II, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Research Unit of Molecular Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany. · Institute of Genetic Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany. · Institute of Epidemiology I, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany; Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany; Klinikum Grosshadern, Munich, Germany. · Bone and Joint Research Group, Department of Medicine, University of Auckland, Auckland, New Zealand. · Department of Medicine, University of Otago, Christchurch, New Zealand. · Department of Psychiatry/EMGO Institute, VU University Medical Centre, Amsterdam, the Netherlands. · Laboratory of Genetics, National Institute on Aging (NIA), Baltimore, MD, United States of America. · Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Turku, Finland. · University Hospital Regensburg, Regensburg, Germany. · Department of Medicine, Nephrology Division, Lausanne University Hospital, Lausanne, Switzerland. · Institute of Medical Informatics, Biometry and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-University, Munich, Germany. · Max Planck Institute of Psychiatry, Munich, Germany. · Institute for Community Medicine, University Medicine Greifswald, Greifswald, Germany. · Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Turku, Finland; Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom; University of Helsinki, Institute of Molecular Medicine, Helsinki, Finland. · Department of Mathematics and Informatics, Università di Cagliari, Cagliari, Italy; Department of Statistics, Universidad Carlos III de Madrid, Madrid, Spain. · Human Genetics, Wellcome Trust Sanger Institute, Hinxton, United Kingdom. · Faculty of Medicine, University of Split, Croatia, Soltanska 2, Split, 21000, Croatia; Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh, Scotland, United Kingdom. · Queen Mary, University of London, London, United Kingdom. · Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands; Department of Epidemiology, Subdivision Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands; Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands. · Department of Epidemiology, Subdivision Genetic Epidemiology, Erasmus MC, Rotterdam, The Netherlands. · Institute of Internal Medicine, Renal Program, Columbus-Gemelli University Hospital, Catholic University, Rome, Italy. · Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, 751 85, Sweden. · on behalf of PROCARDIS; Department of Cardiovascular Medicine, Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. · Estonian Genome Center, University of Tartu, Tartu, Estonia; Department of Chronic Disease Prevention, National Institute for Health and Welfare (THL), Helsinki, Finland; University of Helsinki, Institute of Molecular Medicine, Helsinki, Finland. · University Institute of Social and Preventive Medicine, Lausanne, Switzerland. · Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, United States of America; Renal Division, Freiburg University Hospital, Freiburg, Germany. ·PLoS One · Pubmed #25811787.

ABSTRACT: We tested for interactions between body mass index (BMI) and common genetic variants affecting serum urate levels, genome-wide, in up to 42569 participants. Both stratified genome-wide association (GWAS) analyses, in lean, overweight and obese individuals, and regression-type analyses in a non BMI-stratified overall sample were performed. The former did not uncover any novel locus with a major main effect, but supported modulation of effects for some known and potentially new urate loci. The latter highlighted a SNP at RBFOX3 reaching genome-wide significant level (effect size 0.014, 95% CI 0.008-0.02, Pinter= 2.6 x 10-8). Two top loci in interaction term analyses, RBFOX3 and ERO1LB-EDARADD, also displayed suggestive differences in main effect size between the lean and obese strata. All top ranking loci for urate effect differences between BMI categories were novel and most had small magnitude but opposite direction effects between strata. They include the locus RBMS1-TANK (men, Pdifflean-overweight= 4.7 x 10-8), a region that has been associated with several obesity related traits, and TSPYL5 (men, Pdifflean-overweight= 9.1 x 10-8), regulating adipocytes-produced estradiol. The top-ranking known urate loci was ABCG2, the strongest known gout risk locus, with an effect halved in obese compared to lean men (Pdifflean-obese= 2 x 10-4). Finally, pathway analysis suggested a role for N-glycan biosynthesis as a prominent urate-associated pathway in the lean stratum. These results illustrate a potentially powerful way to monitor changes occurring in obesogenic environment.

3 Article Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. 2013

Köttgen, Anna / Albrecht, Eva / Teumer, Alexander / Vitart, Veronique / Krumsiek, Jan / Hundertmark, Claudia / Pistis, Giorgio / Ruggiero, Daniela / O'Seaghdha, Conall M / Haller, Toomas / Yang, Qiong / Tanaka, Toshiko / Johnson, Andrew D / Kutalik, Zoltán / Smith, Albert V / Shi, Julia / Struchalin, Maksim / Middelberg, Rita P S / Brown, Morris J / Gaffo, Angelo L / Pirastu, Nicola / Li, Guo / Hayward, Caroline / Zemunik, Tatijana / Huffman, Jennifer / Yengo, Loic / Zhao, Jing Hua / Demirkan, Ayse / Feitosa, Mary F / Liu, Xuan / Malerba, Giovanni / Lopez, Lorna M / van der Harst, Pim / Li, Xinzhong / Kleber, Marcus E / Hicks, Andrew A / Nolte, Ilja M / Johansson, Asa / Murgia, Federico / Wild, Sarah H / Bakker, Stephan J L / Peden, John F / Dehghan, Abbas / Steri, Maristella / Tenesa, Albert / Lagou, Vasiliki / Salo, Perttu / Mangino, Massimo / Rose, Lynda M / Lehtimäki, Terho / Woodward, Owen M / Okada, Yukinori / Tin, Adrienne / Müller, Christian / Oldmeadow, Christopher / Putku, Margus / Czamara, Darina / Kraft, Peter / Frogheri, Laura / Thun, Gian Andri / Grotevendt, Anne / Gislason, Gauti Kjartan / Harris, Tamara B / Launer, Lenore J / McArdle, Patrick / Shuldiner, Alan R / Boerwinkle, Eric / Coresh, Josef / Schmidt, Helena / Schallert, Michael / Martin, Nicholas G / Montgomery, Grant W / Kubo, Michiaki / Nakamura, Yusuke / Tanaka, Toshihiro / Munroe, Patricia B / Samani, Nilesh J / Jacobs, David R / Liu, Kiang / D'Adamo, Pio / Ulivi, Sheila / Rotter, Jerome I / Psaty, Bruce M / Vollenweider, Peter / Waeber, Gerard / Campbell, Susan / Devuyst, Olivier / Navarro, Pau / Kolcic, Ivana / Hastie, Nicholas / Balkau, Beverley / Froguel, Philippe / Esko, Tõnu / Salumets, Andres / Khaw, Kay Tee / Langenberg, Claudia / Wareham, Nicholas J / Isaacs, Aaron / Kraja, Aldi / Zhang, Qunyuan / Wild, Philipp S / Scott, Rodney J / Holliday, Elizabeth G / Org, Elin / Viigimaa, Margus / Bandinelli, Stefania / Metter, Jeffrey E / Lupo, Antonio / Trabetti, Elisabetta / Sorice, Rossella / Döring, Angela / Lattka, Eva / Strauch, Konstantin / Theis, Fabian / Waldenberger, Melanie / Wichmann, H-Erich / Davies, Gail / Gow, Alan J / Bruinenberg, Marcel / Anonymous6210745 / Stolk, Ronald P / Kooner, Jaspal S / Zhang, Weihua / Winkelmann, Bernhard R / Boehm, Bernhard O / Lucae, Susanne / Penninx, Brenda W / Smit, Johannes H / Curhan, Gary / Mudgal, Poorva / Plenge, Robert M / Portas, Laura / Persico, Ivana / Kirin, Mirna / Wilson, James F / Mateo Leach, Irene / van Gilst, Wiek H / Goel, Anuj / Ongen, Halit / Hofman, Albert / Rivadeneira, Fernando / Uitterlinden, Andre G / Imboden, Medea / von Eckardstein, Arnold / Cucca, Francesco / Nagaraja, Ramaiah / Piras, Maria Grazia / Nauck, Matthias / Schurmann, Claudia / Budde, Kathrin / Ernst, Florian / Farrington, Susan M / Theodoratou, Evropi / Prokopenko, Inga / Stumvoll, Michael / Jula, Antti / Perola, Markus / Salomaa, Veikko / Shin, So-Youn / Spector, Tim D / Sala, Cinzia / Ridker, Paul M / Kähönen, Mika / Viikari, Jorma / Hengstenberg, Christian / Nelson, Christopher P / Anonymous6220745 / Anonymous6230745 / Anonymous6240745 / Anonymous6250745 / Meschia, James F / Nalls, Michael A / Sharma, Pankaj / Singleton, Andrew B / Kamatani, Naoyuki / Zeller, Tanja / Burnier, Michel / Attia, John / Laan, Maris / Klopp, Norman / Hillege, Hans L / Kloiber, Stefan / Choi, Hyon / Pirastu, Mario / Tore, Silvia / Probst-Hensch, Nicole M / Völzke, Henry / Gudnason, Vilmundur / Parsa, Afshin / Schmidt, Reinhold / Whitfield, John B / Fornage, Myriam / Gasparini, Paolo / Siscovick, David S / Polašek, Ozren / Campbell, Harry / Rudan, Igor / Bouatia-Naji, Nabila / Metspalu, Andres / Loos, Ruth J F / van Duijn, Cornelia M / Borecki, Ingrid B / Ferrucci, Luigi / Gambaro, Giovanni / Deary, Ian J / Wolffenbuttel, Bruce H R / Chambers, John C / März, Winfried / Pramstaller, Peter P / Snieder, Harold / Gyllensten, Ulf / Wright, Alan F / Navis, Gerjan / Watkins, Hugh / Witteman, Jacqueline C M / Sanna, Serena / Schipf, Sabine / Dunlop, Malcolm G / Tönjes, Anke / Ripatti, Samuli / Soranzo, Nicole / Toniolo, Daniela / Chasman, Daniel I / Raitakari, Olli / Kao, W H Linda / Ciullo, Marina / Fox, Caroline S / Caulfield, Mark / Bochud, Murielle / Gieger, Christian. ·Renal Division, Freiburg University Hospital, Freiburg, Germany. anna.koettgen@uniklinik-freiburg.de ·Nat Genet · Pubmed #23263486.

ABSTRACT: Elevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with serum urate concentrations (18 new regions in or near TRIM46, INHBB, SFMBT1, TMEM171, VEGFA, BAZ1B, PRKAG2, STC1, HNF4G, A1CF, ATXN2, UBE2Q2, IGF1R, NFAT5, MAF, HLF, ACVR1B-ACVRL1 and B3GNT4). Associations for many of the loci were of similar magnitude in individuals of non-European ancestry. We further characterized these loci for associations with gout, transcript expression and the fractional excretion of urate. Network analyses implicate the inhibins-activins signaling pathways and glucose metabolism in systemic urate control. New candidate genes for serum urate concentration highlight the importance of metabolic control of urate production and excretion, which may have implications for the treatment and prevention of gout.

4 Article Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors. 2010

Yang, Qiong / Köttgen, Anna / Dehghan, Abbas / Smith, Albert V / Glazer, Nicole L / Chen, Ming-Huei / Chasman, Daniel I / Aspelund, Thor / Eiriksdottir, Gudny / Harris, Tamara B / Launer, Lenore / Nalls, Michael / Hernandez, Dena / Arking, Dan E / Boerwinkle, Eric / Grove, Megan L / Li, Man / Linda Kao, W H / Chonchol, Michel / Haritunians, Talin / Li, Guo / Lumley, Thomas / Psaty, Bruce M / Shlipak, Michael / Hwang, Shih-Jen / Larson, Martin G / O'Donnell, Christopher J / Upadhyay, Ashish / van Duijn, Cornelia M / Hofman, Albert / Rivadeneira, Fernando / Stricker, Bruno / Uitterlinden, Andre G / Paré, Guillaume / Parker, Alex N / Ridker, Paul M / Siscovick, David S / Gudnason, Vilmundur / Witteman, Jacqueline C / Fox, Caroline S / Coresh, Josef. ·Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. ·Circ Cardiovasc Genet · Pubmed #20884846.

ABSTRACT: BACKGROUND: Elevated serum urate levels can lead to gout and are associated with cardiovascular risk factors. We performed a genome-wide association study to search for genetic susceptibility loci for serum urate and gout and investigated the causal nature of the associations of serum urate with gout and selected cardiovascular risk factors and coronary heart disease (CHD). METHODS AND RESULTS: Meta-analyses of genome-wide association studies (GWAS) were performed in 5 population-based cohorts of the Cohorts for Heart and Aging Research in Genome Epidemiology consortium for serum urate and gout in 28 283 white participants. The effect of the most significant single-nucleotide polymorphism at all genome-wide significant loci on serum urate was added to create a genetic urate score. Findings were replicated in the Women's Genome Health Study (n=22 054). Single-nucleotide polymorphisms at 8 genetic loci achieved genome-wide significance with serum urate levels (P=4×10(-8) to 2×10(-242) in SLC22A11, GCKR, R3HDM2-INHBC region, RREB1, PDZK1, SLC2A9, ABCG2, and SLC17A1). Only 2 loci (SLC2A9, ABCG2) showed genome-wide significant association with gout. The genetic urate score was strongly associated with serum urate and gout (odds ratio, 12.4 per 100 μmol/L; P=3×10(-39)) but not with blood pressure, glucose, estimated glomerular filtration rate, chronic kidney disease, or CHD. The lack of association between the genetic score and the latter phenotypes also was observed in the Women's Genome Health Study. CONCLUSIONS: The genetic urate score analysis suggested a causal relationship between serum urate and gout but did not provide evidence for one between serum urate and cardiovascular risk factors and CHD.