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Gout: HELP
Articles by Lina Zgaga
Based on 2 articles published since 2008

Between 2008 and 2019, Lina Zgaga wrote the following 2 articles about Gout.
+ Citations + Abstracts
1 Article The association of dietary intake of purine-rich vegetables, sugar-sweetened beverages and dairy with plasma urate, in a cross-sectional study. 2012

Zgaga, Lina / Theodoratou, Evropi / Kyle, Janet / Farrington, Susan M / Agakov, Felix / Tenesa, Albert / Walker, Marion / McNeill, Geraldine / Wright, Alan F / Rudan, Igor / Dunlop, Malcolm G / Campbell, Harry. ·Centre for Population Health Sciences, University of Edinburgh, Edinburgh, United Kingdom. lina.zgaga@ed.ac.uk ·PLoS One · Pubmed #22701608.

ABSTRACT: INTRODUCTION: Hyperuricemia is a strong risk factor for gout. The incidence of gout and hyperuricemia has increased recently, which is thought to be, in part, due to changes in diet and lifestyle. Objective of this study was to investigate the association between plasma urate concentration and: a) food items: dairy, sugar-sweetened beverages (SSB) and purine-rich vegetables; b) related nutrients: lactose, calcium and fructose. METHODS: A total of 2,076 healthy participants (44% female) from a population-based case-control study in Scotland (1999-2006) were included in this study. Dietary data was collected using a semi-quantitative food frequency questionnaire (FFQ). Nutrient intake was calculated using FFQ and composition of foods information. Urate concentration was measured in plasma. RESULTS: Mean urate concentration was 283.8±72.1 mmol/dL (females: 260.1±68.9 mmol/dL and males: 302.3±69.2 mmol/dL). Using multivariate regression analysis we found that dairy, calcium and lactose intakes were inversely associated with urate (p = 0.008, p = 0.003, p = 0.0007, respectively). Overall SSB consumption was positively associated with urate (p = 0.008), however, energy-adjusted fructose intake was not associated with urate (p = 0.66). The intake of purine-rich vegetables was not associated to plasma urate (p = 0.38). CONCLUSIONS: Our results suggest that limiting purine-rich vegetables intake for lowering plasma urate may be ineffectual, despite current recommendations. Although a positive association between plasma urate and SSB consumption was found, there was no association with fructose intake, suggesting that fructose is not the causal agent underlying the SSB-urate association. The abundant evidence supporting the inverse association between plasma urate concentration and dairy consumption should be reflected in dietary guidelines for hyperuricemic individuals and gout patients. Further research is needed to establish which nutrients and food products influence plasma urate concentration, to inform the development of evidence-based dietary guidelines.

2 Article SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout. 2008

Vitart, Veronique / Rudan, Igor / Hayward, Caroline / Gray, Nicola K / Floyd, James / Palmer, Colin N A / Knott, Sara A / Kolcic, Ivana / Polasek, Ozren / Graessler, Juergen / Wilson, James F / Marinaki, Anthony / Riches, Philip L / Shu, Xinhua / Janicijevic, Branka / Smolej-Narancic, Nina / Gorgoni, Barbara / Morgan, Joanne / Campbell, Susan / Biloglav, Zrinka / Barac-Lauc, Lovorka / Pericic, Marijana / Klaric, Irena Martinovic / Zgaga, Lina / Skaric-Juric, Tatjana / Wild, Sarah H / Richardson, William A / Hohenstein, Peter / Kimber, Charley H / Tenesa, Albert / Donnelly, Louise A / Fairbanks, Lynette D / Aringer, Martin / McKeigue, Paul M / Ralston, Stuart H / Morris, Andrew D / Rudan, Pavao / Hastie, Nicholas D / Campbell, Harry / Wright, Alan F. ·MRC Human Genetics Unit, Western General Hospital, Edinburgh EH4 2XU, UK. ·Nat Genet · Pubmed #18327257.

ABSTRACT: Uric acid is the end product of purine metabolism in humans and great apes, which have lost hepatic uricase activity, leading to uniquely high serum uric acid concentrations (200-500 microM) compared with other mammals (3-120 microM). About 70% of daily urate disposal occurs via the kidneys, and in 5-25% of the human population, impaired renal excretion leads to hyperuricemia. About 10% of people with hyperuricemia develop gout, an inflammatory arthritis that results from deposition of monosodium urate crystals in the joint. We have identified genetic variants within a transporter gene, SLC2A9, that explain 1.7-5.3% of the variance in serum uric acid concentrations, following a genome-wide association scan in a Croatian population sample. SLC2A9 variants were also associated with low fractional excretion of uric acid and/or gout in UK, Croatian and German population samples. SLC2A9 is a known fructose transporter, and we now show that it has strong uric acid transport activity in Xenopus laevis oocytes.