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Gout: HELP
Articles from Serbia
Based on 2 articles published since 2008

These are the 2 published articles about Gout that originated from Serbia during 2008-2019.
+ Citations + Abstracts
1 Article Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines. 2014

Schauer, Christine / Janko, Christina / Munoz, Luis E / Zhao, Yi / Kienhöfer, Deborah / Frey, Benjamin / Lell, Michael / Manger, Bernhard / Rech, Jürgen / Naschberger, Elisabeth / Holmdahl, Rikard / Krenn, Veit / Harrer, Thomas / Jeremic, Ivica / Bilyy, Rostyslav / Schett, Georg / Hoffmann, Markus / Herrmann, Martin. ·Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany. · 1] Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany. [2] Department of Otorhinolaryngology, Head and Neck Surgery, Section for Experimental Oncology and Nanomedicine (SEON), University Hospital Erlangen, Erlangen, Germany. · 1] Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany. [2] Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, China. · Department of Radiation Oncology, University Hospital Erlangen, Erlangen, Germany. · Department of Radiology, Friedrich-Alexander University of Erlangen-Nuremberg, Erlangen, Germany. · Division of Molecular and Experimental Surgery, Department of Surgery, University of Erlangen Medical Center, Erlangen, Germany. · Division of Medical Inflammation Research, Department of Medical Biochemistry and Biophysics, Karolinska Institute, Stockholm, Sweden. · Department of Pathology, MVZ of Pathology, Trier, Germany. · 1] Department of Internal Medicine 3, University of Erlangen-Nuremberg, Erlangen, Germany. [2] Institute of Rheumatology, School of Medicine, University of Belgrade, Belgrade, Serbia. · Institute of Cell Biology, National Academy of Sciences of Ukraine, Lviv, Ukraine. ·Nat Med · Pubmed #24784231.

ABSTRACT: Gout is characterized by an acute inflammatory reaction and the accumulation of neutrophils in response to monosodium urate (MSU) crystals. Inflammation resolves spontaneously within a few days, although MSU crystals can still be detected in the synovial fluid and affected tissues. Here we report that neutrophils recruited to sites of inflammation undergo oxidative burst and form neutrophil extracellular traps (NETs). Under high neutrophil densities, these NETs aggregate and degrade cytokines and chemokines via serine proteases. Tophi, the pathognomonic structures of chronic gout, share characteristics with aggregated NETs, and MSU crystals can induce NETosis and aggregation of NETs. In individuals with impaired NETosis, MSU crystals induce uncontrolled production of inflammatory mediators from neutrophils and persistent inflammation. Furthermore, in models of neutrophilic inflammation, NETosis-deficient mice develop exacerbated and chronic disease that can be reduced by adoptive transfer of aggregated NETs. These findings suggest that aggregated NETs promote the resolution of neutrophilic inflammation by degrading cytokines and chemokines and disrupting neutrophil recruitment and activation.

2 Article [Quality of treatment in gouty patients considering EULAR recommendations]. 2012

Radak-Perović, Marija / Zlatković-Svenda, Mirjana. ·School of Medicine, University of Belgrade, Belgrade, Serbia. ·Srp Arh Celok Lek · Pubmed #23350244.

ABSTRACT: INTRODUCTION: There are 12 recommendations for gout treatment, based on evidence and opinion of experts. OBJECTIVE: To assess the quality of therapy in patients with gout analyzing adherence to four selected recommendations. METHODS: Retrospective cross sectional study of 111 patients with gouty flare was conducted. Adherence to selected recommendation was defined as odds ratio between the number of patients whose therapy adhered to treatment recommendation and the number of patients eligible for the relevant recommendation. These recommendations refer to indications for allopurinol treatment (R1), prophylaxis of induced gouty flares in the first month of allopurinol treatment (R2), treatment goals (R3), and treatment monitoring regime (R4). RESULTS: Out of 111 patients with gout, 25 with tophi, 87 with frequent gouty flares and 46 with CUA or X-ray erosions were indicated for allopurinol treatment. The adherence to R1 was 76% for tophi patients, 54% for patients with frequent gouty flares, and 63% for patients with CUA. None of the patients starting allopurinol was either recruited for gouty prophylaxis or monitored properly; adherence to R2 as well as to R4 was 0%. Target serum uric acid (SUc) rating below 360 micromol/L was achieved in 13/50 patients treated with allopurinol, while the adherence to R3 was 26%. Therapeutic monitoring in accordance with P4 was not done in any of the patients on allopurinol. There were no differences in mean levels of the SUc between allopurinol users and non-users: 471.3 +/- 164.4 vs. 460.0 +/- 103.5 micromol/L (p = 0.067). Therefore, almost every second patient with gouty flares was on allopurinol therapy (50/111). CONCLUSION: The degree of deviation in relation to the key principles of correct treatment in patients with gout ranged from a relatively high (24%) to that of absolute digression (100%).