Pick Topic
Review Topic
List Experts
Examine Expert
Save Expert
  Site Guide ··   
Gout: HELP
Articles from Miscellaneous cities in China
Based on 87 articles published since 2008
||||

These are the 87 published articles about Gout that originated from Miscellaneous cities in China during 2008-2019.
 
+ Citations + Abstracts
Pages: 1 · 2 · 3 · 4
1 Review A novel uromodulin mutation in autosomal dominant tubulointerstitial kidney disease: a pedigree-based study and literature review. 2018

Lin, Ziqiang / Yang, Juan / Liu, Hong / Cai, Dan / An, Zhenmei / Yu, Yerong / Chen, Tao. ·a Department of Endocrinology and Metabolism , West China Hospital of Sichuan University , Chengdu , P. R. China. · b Department of Endocrinology , Guihang 302 Hospital , Anshun , P. R. China. · c Department of Endocrinology , Science City Hospital of Sichuan Province , Mianyang , P. R. China. · d Department of Endocrinology , PI County People's Hospital , Chengdu , P. R. China. ·Ren Fail · Pubmed #29569962.

ABSTRACT: Autosomal dominant tubulointerstitial kidney disease caused by mutations in uromodulin gene (ADTKD-UMOD) is a spectrum of hereditary renal disorders, characterized by early-onset hyperuricemia, gout and progressive nephropathy. This study presented a novel UMOD mutation in an ADTKD pedigree and reviewed studies in Chinese population. The index patient is a 16-year-old girl with hypertension, hyperuricemia and normal serum creatinine level. Four affected and six unaffected members were available for genetic screen. The mutation analysis was performed by next-generation sequencing and direct sequencing. A literature research was conducted to review Chinese ADTKD-UMOD cases. MEDLINE and Chinese Biomedicine Databases were searched with 'uromodulin', 'juvenile gout' and their related terms. Genetic sequencing revealed a de novo mutation within exon 3 (Cys223Gly), which was co-segregating with phenotype in this pedigree. In the review, four studies and our study involving a total of 67 ADTKD patients from 11 families were identified. Of these patients, 27 were confirmed to carry UMOD mutations. Mutations occurred in exon 3 were commonly observed, while mutations within exon 4, 5 and 9 occurred less frequently in Chinese ADTKD-UMOD cases. Among these cases, median age of symptom onset was 26.5 years, median age of end-stage renal diseases (ESRD) or death by ESRD was 41.9 years without renal replacement treatment. Phenotype caused by mutations in D8C domain seemed to be severe than those in GPI domain. Compared with patients of other race, Chinese ADTKD-UMOD patients advanced more aggressively to ESRD.

2 Review Research progress in the genetics of hyperuricaemia and gout. 2016

Zheng, Min / Ma, Jun-wu. ·National Key Laboratory for Swine Genetics, Breeding and Production Technology, Jiangxi Agricultural University, Nanchang 330045, China. ·Yi Chuan · Pubmed #27103454.

ABSTRACT: Gout is one of the most common inflammatory arthritis caused by hyperuricaemia, which is affected by both genetic factors and environmental factors. Early researches show that a few of rare monogenic mutations, such as PRPS1 and HPRT1 mutations, lead to abnormal purine anabolism and then cause hyperuricaemia and gout. In recent years, genome-wide association studies (GWAS) have identified dozens of susceptibility loci and/or candidate genes associated with hyperuricemia and gout. Loss-of-function mutations in SLC2A9, SLC22A11, and SLC22A12 cause hereditary hypouricaemia, while their overexpression may increase the reabsorption of uric acid. In contrast, loss-of-function mutations in ABCG2, SLC17A1, and SLC17A3 cause urate underexcretion of renal and intestinal. These variations leading to blood uric acid excretion disorder (excess reabsorption and underexcretion) are the main genetic factors affecting hyperuicemia and gout. Moreover, to some degree, inhibins-activins growth factor system, transcription factors, cytoskeleton and gene-environment interaction can also affect the level of blood uric acid. In addition, two risk genes, RFX3 and KCNQ1, which might impair immune response and lead to functional deficiency of beta cell were recently discovered to influence hyperuiceamia and gout in Han Chinese. This paper systematically reviews genetic studies on hyperuricaemia and gout to improve our understanding of pathogenesis of hyperuricaemia and gout.

3 Review Increased Risk of Cancer in relation to Gout: A Review of Three Prospective Cohort Studies with 50,358 Subjects. 2015

Wang, Weijie / Xu, Donghua / Wang, Bin / Yan, Shushan / Wang, Xiaochen / Yin, Yin / Wang, Xuehao / Sun, Beicheng / Sun, Xiaoyang. ·Department of Neurosurgery, Huai'an First People's Hospital Affiliated to Nanjing Medical University, 6 Beijing Road West, Huai'an 223300, China. · Department of Rheumatology, The First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China ; Liver Transplantation Center of the First Affiliated Hospital and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210002, China. · Department of Endocrinology, The Affiliated Hospital of Medical College, Qingdao University, Qingdao 266003, China. · Liver Transplantation Center of the First Affiliated Hospital and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210002, China ; Department of Surgical Oncology, The Eighty-First Hospital of People's Liberation Army, Nanjing 210002, China. · Liver Transplantation Center of the First Affiliated Hospital and State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210002, China. ·Mediators Inflamm · Pubmed #26504360.

ABSTRACT: Gout is a common inflammatory disease characterized by acute arthritis and hyperuricemia. A number of epidemiological studies have suggested the critical role of gout in carcinogenesis. The aim of this study was to estimate the association between gout and cancer risk by meta-analysis of all relevant studies published to date. A comprehensive literature search in PubMed and Embase databases from their inception up to July 1, 2014, was performed to identify eligible studies. The strength for relationship between gout and the risk of different cancers was evaluated by calculating pooled relative risks (RRs) with 95% confidence intervals (95% CIs). All analyses were carried out by STATA 12.0 software. Gout patients were at an increased risk of cancer, particularly urological cancers, digestive system cancers, and lung cancer. No such significant association between gout and the risk of breast or brain cancers was observed. Sensitivity analysis did not materially alter the pooled results. Gout is a risk factor of cancer, particularly that of urological cancers, digestive system cancers, and lung cancer. The pooled data further support the hypothesis of a link between gout and carcinogenesis.

4 Review Could MicroRNAs be Regulators of Gout Pathogenesis? 2015

Wang, Yangang / Xu, Donghua / Wang, Bin / Hou, Xu. ·Department of Endocrinology, Affiliated Hospital of Qingdao University, Qingdao, China. ·Cell Physiol Biochem · Pubmed #26279417.

ABSTRACT: MicroRNAs (miRNAs) are a class of noncoding RNAs that mainly negatively regulate gene expression. miRNAs have important roles in many diseases, including inflammatory diseases. Gout is a common arthritis caused by deposition of monosodium urate crystals within joints. Recent studies suggested that miRNAs may be involved in the development of inflammatory arthritis, including acute gouty arthritis. In the present review, we systemically discuss relevant publications in order to provide a better understanding on the possible role of miRNAs in gout. miRNAs may act as regulators of gout pathogenesis via several pathways. Targeting miRNAs may be a promisingstrategy in the treatment of gout.

5 Review Parathyroid disease. 2010

Wen, Hong Yan / Schumacher, H Ralph / Zhang, Li Yun. ·Shanxi Medical University, 86# South Xinjian, Shanxi Province, China. ·Rheum Dis Clin North Am · Pubmed #21092844.

ABSTRACT: Patients with parathyroid disease can have important musculoskeletal problems.Hypoparathyroidism can cause subcutaneous calcifications, tetany, muscle cramps,and paresthesias, but also myopathies and an ankylosing spondylitis-like back disease. Hypoparathyroidism can occur in SLE caused by antiparathyroid antibodies.Patients with hyperparathyroidism can develop bone disease with cysts, erosions,and deformities. They can also develop pseudogout, gout, myopathies, and tendon ruptures.

6 Clinical Trial A phase 3, multicenter, randomized, allopurinol-controlled study assessing the safety and efficacy of oral febuxostat in Chinese gout patients with hyperuricemia. 2015

Xu, Shaoyong / Liu, Xiangyang / Ming, Jie / Chen, Shenren / Wang, Yangang / Liu, Xiumei / Liu, Hong / Peng, Yongde / Wang, Jianqin / Lin, Jinying / Ji, Haiwang / Liu, Bin / Lu, Ying / Liu, Peng / Zhang, Yonghong / Ji, Qiuhe. ·Department of Endocrinology, Xijing Hospital, Fourth Military Medical University, Xi'an, China. · Department of Endocrinology, the Second Affiliated Hospital of Shantou University Medical College, Shantou, China. · Department of Endocrinology, the Affiliated Hospital of Qingdao University, Qingdao, China. · Department of Rheumatology, the First Hospital of Shanxi Medical University, Taiyuan, China. · Department of Endocrinology, the First Affiliated Hospital of Guangxi Medical University, Nanning, China. · Department of Endocrinology, Shanghai General Hospital, Shanghai, China. · Department of Nephrology, Lanzhou University Second Hospital, Lanzhou, China. · Department of Hematology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China. · Department of Traditional Chinese Medicine and Rheumatology, Shaanxi Provincial People's Hospital, Xi'an, China. · Department of Hand and Foot Surgery, the First Hospital of Jilin University, Jilin, China. · Department of Nephrology, Zhejiang Provincial Tongde Hospital, Hangzhou, China. · Department of Endocrinology, Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning, China. · Department of Rheumatology, Luoyang Orthopedic-Traumatological Hospital, Luoyang, China. ·Int J Rheum Dis · Pubmed #26013187.

ABSTRACT: AIM: To compare the efficiency and safety of febuxostat with those of allopurinol in Chinese patients with gout and hyperuricemia. METHODS: The trial which was conducted at 13 centers in China during 2011-2013 included a 2-week run-in and a 24-week treatment period. A total of 504 eligible participants with gout and with serum urate ≥ 480 μmol/L were randomly assigned 1 : 1 : 1 to febuxostat 40 mg/day, febuxostat 80 mg/day and allopurinol 300 mg/day groups. The primary efficacy endpoint was the percentage of subjects whose last three serum urate levels were < 360 μmol/L. RESULTS: The primary efficacy endpoint was reached by 33.5% of subjects taking febuxostat 80 mg/day, 22.5% of those taking febuxostat 40 mg/day and 17.0% of those taking allopurinol 300 mg/day (P < 0.001 for the comparison between febuxostat 80 mg/day and allopurinol 300 mg/day groups; P = 0.216 for the comparison between febuxostat 40 mg/day and allopurinol 300 mg/day groups). The incidence of gout flare was relatively high in each group during the first 8 weeks and gradually decreased thereafter. There was no statistically significant difference between the three groups (P > 0.05). The incidence of adverse events was similar in the three treatment groups. The most frequent treatment-related adverse events were liver function test abnormalities. CONCLUSIONS: Febuxostat 80 mg/day had superior urate-lowering efficacy to that of febuxostat 40 mg/day or allopurinol 300 mg/day, which was comparable in Chinese gout patients with hyperuricemia. Febuxostat, at a daily dose of 40 or 80 mg, was safe and well tolerated.

7 Article Common variants in the 2019

Zhou, Zhaowei / Li, Zhiqiang / Wang, Can / Li, Xinde / Cheng, Xiaoyu / Li, Changgui / Shi, Yongyong. ·1Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiaric Disorders (Ministry of Education), Shanghai Jiao Tong University, No. 1954 Huashan Road, Shanghai, 200030 People's Republic of China. · 0000 0004 0368 8293 · grid.16821.3c · 2Biomedical Sciences Institute, the Qingdao Branch of SJTU Bio-X Institutes, Qingdao University, Qingdao, 266003 People's Republic of China. · 0000 0001 0455 0905 · grid.410645.2 · 3Qingdao Key Laboratory of Gout, The Affiliated Hospital of Qingdao University, Qingdao, 266003 People's Republic of China. · grid.412521.1 · 4Shandong Provincial Key Laboratory of Metabolic Disease, The Affiliated Hospital of Qingdao University, Qingdao, 266003 People's Republic of China. · 5Metabolic Disease Institute, Qingdao University, Qingdao, 266003 People's Republic of China. · 6The Department of Endocrinology and Metabolism, The Affiliated Hospital of Qingdao University, No.16 Jiangsu Road, Qingdao, 266003 People's Republic of China. ·Hereditas · Pubmed #30679935.

ABSTRACT: Background: Serum uric acid (SUA), hyperuricemia (HUA) and gout are complex traits with relatively high heritability. This study aims to identify whether a candidate gene, Results: Three sample sets of 1376 gout patients, 1290 long-term HUA subjects (no gout attack) and 1349 normouricemic controls were recruited for this study. Eight polymorphisms in the Conclusions: Our findings support the associations of the

8 Article Resveratrol attenuates the MSU crystal-induced inflammatory response through the inhibition of TAK1 activity. 2019

Li, Hongmei / Ou, Guochun / He, Yonglong / Ren, Long / Yang, Xiaohong / Zeng, Mei. ·Preclinical School of North SiChuan Medical College, 234# Fujiang Road, Nanchong 637000, Sichuan, China. · Institute of Rheumatology and Immunology, The Affiliated Hospital of North Sichuan Medical College, 63# Wenhua Road, Nanchong 637000, Sichuan, China. · The Fifth People's Hospital of Nanchong City, 21#Bajiao Street, Nanchong 637100, Sichuan, China. · Institute of Rheumatology and Immunology, The Affiliated Hospital of North Sichuan Medical College, 63# Wenhua Road, Nanchong 637000, Sichuan, China; Sichuan Key Laboratory of Medical Imaging, North SiChuan Medical College, 234# Fujiang Road, Nanchong 637000, Sichuan, China; Preclinical School of North SiChuan Medical College, 234# Fujiang Road, Nanchong 637000, Sichuan, China. Electronic address: zengmei123@gmail.com. ·Int Immunopharmacol · Pubmed #30537632.

ABSTRACT: TAK1 is closely associated with the NF-κB and MAPK signaling pathways. In the present study, we aimed to explore the relationship between TAK1 and gout as well as the effects of resveratrol on TAK1 activity and MSU crystal-induced inflammation. The expression levels of total TAK1 and phosphorylated TAK1 in gout patients were detected by western blotting. The influence of resveratrol on TAK1 activity and MSU crystal-induced inflammation was investigated in THP-1 cell and murine models of gout. The results showed that TAK1 and p-TAK1 were highly expressed in gouty arthritis patients. MSU crystals accelerated the expression of TAK1 and p-TAK1 in human PBMCs. The anti-inflammatory effects of resveratrol on MSU crystal-induced inflammation in vitro and in vivo included the alleviation of pro-inflammatory cytokines, inflammatory cell recruitment and foot swelling. Resveratrol limited the activation of TAK1 and its downstream signaling pathway, including the degradation of IκBα, the activation of NF-κB P65 and the phosphorylation of P38 and JNK. In conclusion, resveratrol may have a potential therapeutic effect on gouty arthritis by inhibiting TAK1 activity.

9 Article Febuxostat in the treatment of gout patients with low serum uric acid level: 1-year finding of efficacy and safety study. 2018

Shen, Minning / Zhang, Junyu / Qian, Kai / Li, Chunmei / Xu, Wenyu / Gu, Bingjie / Wang, Xiaoqin / Ren, Qijie / Yang, Leilei / Yuan, Hai / Su, Dinglei / Chen, Xingguo. ·Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. · Department of Clinical Laboratory, Changzhou traditional Chinese Medicine Hospital, Changzhou, 213000, China. · Department of Rheumatology and Immunology, Nanjing First Hospital, Nanjing Medical University, Nanjing, 210006, China. 13851750676@163.com. ·Clin Rheumatol · Pubmed #30196323.

ABSTRACT: To retrospectively analyze the efficacy and safety of febuxostat on gout patients with low serum uric acid level. A study was conducted in Nanjing First Hospital from October 2015 to September 2016. Thirty nine acute gouty arthritis patients from the emergency and outpatient department were included. Patients met the 2015 Gout Classification Criteria revised by American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) and had urate deposition around the joints detected by dual-energy computerized tomography (DECT). Patients whose serum uric acid (SUA) were between 5.0 and 7.0 mg/dl (300-420 μmol/l) received febuxostat treatment to maintain the SUA level between 3.0 and 5.0 mg/dl for 1 year. Efficacy and safety of febuxostat were observed during the process. Three of 39 subjects were excluded because of adverse events (AEs) after receiving an initial febuxostat treatment for 2 months. Thirty six subjects were enrolled. The mean SUA level was reduced significantly from 6.51 ± 0.28 mg/dl at baseline to 4.24 ± 0.38 mg/dl and SUA of all subjects decreased by 34.8% compared with baseline. After 1-year treatment, the volume of tophus was reduced approximately 62.8%. Serum creatinine decreased stepwise in 8 gout patients with chronic kidney diseases from 162.5 ± 9.2 μmol/l to 131.4 ± 11.0 μmol/l. Two months after initiation of treatment, the number of gout flares began to markedly decrease and almost did not occur after 1 year. After the 1-year treatment of febuxostat, the average SUA level declined significantly, and the renal function improved gradually. There was nearly complete abolition of gout flares by the end of the study. Tophi resolved markedly compared with baseline as assessed by DECT. Furthermore, only a few people experienced adverse events. Febuxostat has a notable effect for gout patients in the lower SUA level range.

10 Article Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. 2018

He, Hongbin / Jiang, Hua / Chen, Yun / Ye, Jin / Wang, Aoli / Wang, Chao / Liu, Qingsong / Liang, Gaolin / Deng, Xianming / Jiang, Wei / Zhou, Rongbin. ·Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China. · Innovation Center for Cell Signaling Network, University of Science and Technology of China, Hefei, 230027, China. · State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China. · High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui, 230031, China. · Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, University of Science and Technology of China, Hefei, 230026, China. · State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen University, Xiamen, Fujian, 361102, China. xmdeng@xmu.edu.cn. · Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China. ustcjw@ustc.edu.cn. · Hefei National Laboratory for Physical Sciences at Microscale, the CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei, 230027, China. zrb1980@ustc.edu.cn. · Innovation Center for Cell Signaling Network, University of Science and Technology of China, Hefei, 230027, China. zrb1980@ustc.edu.cn. ·Nat Commun · Pubmed #29959312.

ABSTRACT: Oridonin (Ori) is the major active ingredient of the traditional Chinese medicinal herb Rabdosia rubescens and has anti-inflammatory activity, but the target of Ori remains unknown. NLRP3 is a central component of NLRP3 inflammasome and has been involved in a wide variety of chronic inflammation-driven human diseases. Here, we show that Ori is a specific and covalent inhibitor for NLRP3 inflammasome. Ori forms a covalent bond with the cysteine 279 of NLRP3 in NACHT domain to block the interaction between NLRP3 and NEK7, thereby inhibiting NLRP3 inflammasome assembly and activation. Importantly, Ori has both preventive or therapeutic effects on mouse models of peritonitis, gouty arthritis and type 2 diabetes, via inhibition of NLRP3 activation. Our results thus identify NLRP3 as the direct target of Ori for mediating Ori's anti-inflammatory activity. Ori could serve as a lead for developing new therapeutics against NLRP3-driven diseases.

11 Article Isolation and genomic characterization of gosling gout caused by a novel goose astrovirus. 2018

Yang, Jing / Tian, Jiajun / Tang, Yi / Diao, Youxiang. ·College of Animal Science and Technology, Shandong Agricultural University, Tai'an, Shandong Province, China. · Shandong Provincial Key Laboratory of Animal Biotechnology and Disease Control and Prevention, Tai'an, Shandong, China. · Shandong Provincial Engineering Technology Research Center of Animal Disease Control and Prevention, Tai'an, Shandong, China. ·Transbound Emerg Dis · Pubmed #29920970.

ABSTRACT: A severe infectious disease characterized with gout, haemorrhage and swellings of kidneys has affected goslings around the major goose-producing regions in China since November 2016. A Novel goose-origin astrovirus (AStV), designated as AStV/SDPY/Goose/1116/17 (AStV-SDPY) strain, was isolated from diseased goslings, and experimental reproduction of gout was successful using the AStV-SDPY strain. Additionally, the AStV-SDPY was conducted for its full genome sequencing characterization using next-generation sequencing (NGS) technique on Illumina HiSeq platform. A complete genome of the AStV-SDPY was 7,252 nt in length and encoded three viral proteins. Phylogenetic analysis revealed that AStV-SDPY strain belongs to an independent branch of avian astroviruses, and the nucleotide homology among AStV-SDPY and other classic avian astrovirus strains was only 48.8%-68.2%. Results of above data indicated the causative agent of the gosling gout occurring in China is a novel divergent goose astrovirus.

12 Article Metabolomics approach by 2018

Zhang, Yannan / Zhang, Huanzhen / Chang, Dong / Guo, Fuchuan / Pan, Hongzhi / Yang, Yuexin. ·Department of Nutrition and Food Hygiene, School of Public Health, Ningxia Medical University, Yinchuan, 750004, China. · Department of Obstetrics and Gynecology, Tai'an Hospital of Traditional Chinese Medicine, Tai'an, 271000, China. · Department of Clinical Laboratory, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, 201301, China. · Department of Nutrition and Food Safety, School of Public Health, Fujian Medical University, Fuzhou, 350122, China. · Department of Sanitary Inspection, Shanghai University of Medical & Health Sciences, Shanghai, 201318, China. panhongzhilaoshi@163.com. · National Institute for Nutrition and Health, Chinese Center for Disease Control and Prevention, Beijing, 100050, China. yxyang@263.net. ·Arthritis Res Ther · Pubmed #29871692.

ABSTRACT: BACKGROUND: Gout is a metabolic disease and is the most common form of inflammatory arthritis affecting men. However, the pathogenesis of gout is still uncertain, and novel biomarkers are needed for early prediction and diagnosis of gout. The aim of this study was to develop a systemic metabolic profile of patients with asymptomatic hyperuricemia (HUA) and gout by using a metabolomics approach, and find potential pathophysiological mechanisms of and markers of predisposition to gout. METHODS: Serum samples were collected from 149 subjects, including 50 patients with HUA, 49 patients with gout and 50 healthy controls. RESULTS: By serum metabolic profiling, 21 metabolites including lipids and amino acids were significantly altered in patients with HUA or gout. The levels of identified biomarkers together with clinical data showed apparent alteration trends in patients with HUA or gout compared to healthy individuals. According to pathway analysis, three and five metabolic pathways were remarkably perturbed in patients with HUA or gout, respectively. These enriched pathways involve in lipid metabolism, carbohydrate metabolism, amino acids metabolism and energy metabolism. CONCLUSIONS: Taken together, we identified the biomarker signature for HUA and gout, which provides biochemical insights into the metabolic alteration, and identified a continuous progressive axis of development from HUA to gout.

13 Article Effects of breeds, tissues and genders on purine contents in pork and the relationships between purine content and other meat quality traits. 2018

Zheng, Min / Huang, Yizhong / Ji, Jiuxiu / Xiao, Shijun / Ma, Junwu / Huang, Lusheng. ·State Key Laboratory for Swine Genetics, Breeding and Production Technology, Jiangxi Agricultural University, Nanchang 330045, China. · State Key Laboratory for Swine Genetics, Breeding and Production Technology, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address: mjwjxlab@jxau.edu.cn. · State Key Laboratory for Swine Genetics, Breeding and Production Technology, Jiangxi Agricultural University, Nanchang 330045, China. Electronic address: lushenghuang@hotmail.com. ·Meat Sci · Pubmed #29715664.

ABSTRACT: The purine contents of animal foods are becoming widely concerned because excess intake of purine increases the risk of hyperuricemia and gout. In this study, we investigated the impacts of breed, tissue and sex on pork purine content and its correlations with multiple meat quality traits. Among six pig breeds, the average value of total purine contents (TP) in longissimus lumborum muscle was lowest in Chinese Laiwu pigs (114.2 mg/100 g) while highest in Chinese Bamaxiang mini pigs (139.3 mg/100 g). Considerable variations in TP were observed within most breeds, as well as among twelve pork organs with the range from 7 to 245 mg/100 g. However, no significant differences in TP were found between barrows and gilts. Intriguingly, lower purine content in meat was significantly associated with higher ultimate pH, better meat color and more abundant intramuscular fat content and marbling. The results thus suggest that the selection of low-purine pig species is available, which may simultaneously improve other meat quality traits.

14 Article Rate of adherence to urate-lowering therapy among patients with gout: a systematic review and meta-analysis. 2018

Yin, Rulan / Li, Lin / Zhang, Guo / Cui, Yafei / Zhang, Lijuan / Zhang, Qiuxiang / Fu, Ting / Cao, Haixia / Li, Liren / Gu, Zhifeng. ·Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, China. · Emergency and critical care medicine, The First Affiliated Hospital of Soochow University, Suzhou, China. · School of Nursing, Nantong University, Nantong, China. · Department of Operating Room, The First Affiliated Hospital of Soochow University, Suzhou, China. · Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, China. ·BMJ Open · Pubmed #29643150.

ABSTRACT: INTRODUCTION: Reported adherence to urate-lowering therapy (ULT) in gout varies widely (17%-83.5%). Variability may partly be due to different adherence measurement methods. This review aimed to quantify ULT adherence in adult patients with gout. METHODS: This analysis examined studies in PubMed, Web of Science, CNKI Scholar and WanFang databases from inception to January 2017. Papers were selected by inclusion and exclusion criteria in the context. Random-effect meta-analysis estimated adherence. RESULTS: 22 studies were found by the inclusion criteria, which involved 1 37 699 patients with gout. Four ways to define adherence were reported. Meta-analysis revealed that the overall adherence rate was 47% (95% CI 42% to 52%, I CONCLUSIONS: Among adult patients with gout, overall adherence rate to ULT was as low as 47%, which suggested that clinicians should pay more attention to medication adherence in patients with gout to effectively improve adherence to ULT.

15 Article Clinical characteristics of infectious ulceration over tophi in patients with gout. 2018

Xu, Jianjun / Zhu, Zaihua / Zhang, Wei. ·1 Department of Burns, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. · 2 Division of Rheumatology and Immunology, Huashan Hospital, Fudan University, Shanghai 200040, China. · 3 Department of Orthopedics, Wenzhou Central Hospital, Wenzhou 325000, China. ·J Int Med Res · Pubmed #29587574.

ABSTRACT: Objective The aim of this study was to investigate the clinical characteristics of infectious ulceration over tophi in patients with gout. Methods Participants were recruited from the First Affiliated Hospital of Wenzhou Medical University. The clinical characteristics of the patients and wound characteristics were recorded. Results Of the 38 enrolled patients, 18 were found to have infectious ulceration over tophi. Staphylococcus aureus was the most common pathogen and was identified in nine patients. Patients with infection were significantly older (69.6 vs. 60.1 years) and had a worse quality of life than those without infection. Patients with infection also had a significantly longer ulcer duration (125.6 vs. 54.2 days), larger ulcer size (2.47 vs. 1.99 cm

16 Article Development of benzoxazole deoxybenzoin oxime and acyloxylamine derivatives targeting innate immune sensors and xanthine oxidase for treatment of gout. 2018

Huang, Jun / Zhou, Zehao / Zhou, Mengze / Miao, Mingxing / Li, Huanqiu / Hu, Qinghua. ·Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, PR China. · Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China. · Department of Medicinal Chemistry, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, PR China. Electronic address: huanqiuli@suda.edu.cn. · Department of Pharmacology, School of Pharmacy, China Pharmaceutical University, Nanjing 210009, PR China. Electronic address: huqh@cpu.edu.cn. ·Bioorg Med Chem · Pubmed #29472126.

ABSTRACT: Both the inhibition of inflammatory flares and the treatment of hyperuricemia itself are included in the management of gout. Extending our efforts to development of gout therapy, two series of benzoxazole deoxybenzoin oxime derivatives as inhibitors of innate immune sensors and xanthine oxidase (XOD) were discovered in improving hyperuricemia and acute gouty arthritis. In vitro studies revealed that most compounds not only suppressed XOD activity, but blocked activations of NOD-like receptor (NLRP3) inflammasome and Toll-like receptor 4 (TLR4) signaling pathway. More importantly, (E)-1-(6-methoxybenzo[d]oxazol-2-yl)-2-(4-methoxyphenyl)ethanone oxime (5d) exhibited anti-hyperuricemic and anti-acute gouty arthritis activities through regulating XOD, NLRP3 and TLR4. Compound 5d may serve as a tool compound for further design of anti-gout drugs targeting both innate immune sensors and XOD.

17 Article Ultrasound scans and dual energy CT identify tendons as preferred anatomical location of MSU crystal depositions in gouty joints. 2018

Yuan, Yuan / Liu, Chang / Xiang, Xi / Yuan, Tong-Ling / Qiu, Li / Liu, Yi / Luo, Yu-Bin / Zhao, Y / Herrmann, Martin. ·Department of Rheumatology and Immunology, West China Hospital, Sichuan University, 610041, Chengdu, China. · Department of Rheumatology and Immunology, Affiliated Hospital of Southwest Medical University, 646000, Luzhou, China. · Department of Medical Imaging, West China Hospital, Sichuan University, 610041, Chengdu, China. · Department of Musculoskeletal Ultrasound, West China Hospital, Sichuan University, 610041, Chengdu, China. · Department of Rheumatology and Immunology, West China Hospital, Sichuan University, 610041, Chengdu, China. zhao.y1977@163.com. · Department of Internal Medicine 3, University of Erlangen-Nuremberg, 91054, Erlangen, Germany. ·Rheumatol Int · Pubmed #29442150.

ABSTRACT: OBJECTIVE: The present study was performed to localize the articular deposition of monosodium urate (MSU) crystal in joints. We compare the detection efficiencies of dual-energy CT (DECT) and ultrasound scans. METHODS: Analyses by DECT and ultrasound were performed with 184 bilateral joints of the lower limbs of 54 consecutive gout patients. All joints were categorized into (1) knee, (2) ankle, (3) MTP1, and (4) MTP2, and sorted into those with and those without detectable MSU deposition. The comparison of the positive rate between DECT and ultrasound and the agreement was performed using the McNemar test and the Cohen's κ coefficient, respectively. Next, we listed the MSU crystal deposition as assessed by ultrasound between the DECT-positive and -negative joints according to their interior structure. We included tendons, synovia, cartilage, subcutaneous tissue, etc. RESULTS: Among all joints, the percentages with MSU crystal deposition detected by DECT (99/184, 53.8%) and ultrasound (106/184, 57.6%) were comparable (P = 0.530 > 0.05). For MTP1 (21/34, 61.8%; 12/34, 35.3%; P < 0.05) and MTP2-5 (17/34, 50.0%; 10/34, 29.4%, P < 0.05), ultrasound and DECT were more efficient, respectively. The data concordance in 46 of 50 joints (92.00%; κ = 0.769, P < 0.05) for knee; and 27 of 34 joints (79.41%; κ = 0.588, P < 0.05) for MTP2-5 and suggested that tendons were the most frequent anatomical location of MSU crystal deposition. CONCLUSIONS: The tendons are the most frequent anatomical location of MSU crystal depositions. The concordance rate of knee joints and MTP2-5 joints shows good agreement between DECT and ultrasound depending on the location.

18 Article Associations between the SLC22A12 gene and gout susceptibility: a meta-analysis. 2018

Zou, Yao / Du, Jinfeng / Zhu, Yantong / Xie, Xi / Chen, Jinwei / Ling, Guanghui. ·Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, China. · Department of Rheumatology and Immunology, The Second Xiangya Hospital of Central South University, Changsha, China. doctorlgh@163.com. ·Clin Exp Rheumatol · Pubmed #29352852.

ABSTRACT: OBJECTIVES: The aim of this study is to explore whether the polymorphisms of rs475688 and rs3825016 in the solute carrier family 22 member 12 (SLC22A12) gene are associated with the susceptibility to gout or hyperuricaemia. METHODS: Relevant studies were enrolled by searching databases systematically. The pooled odds ratios (ORs) with 95% confidence interval (CI) were used to evaluate the associations. Q-test and I2 statistics were used to evaluate the heterogeneity. Publication bias was evaluated using Begg's funnel plots and Egger regression test. RESULTS: A total of 7 articles involving 1216 patients and 1844 healthy controls were included in this meta-analysis. Significant association was detected between rs475688 polymorphism and gout susceptibility in three genetic models (C vs. T: OR=1.464, 95% CI 1.078-1.989, p=0.015; CC+CT vs. TT: OR=2.028, 95% CI 1.488-2.763, p=0.000; CC vs. CT+TT: OR=2.226, 95% CI 1.746-2.838, p=0.000). Significant association was observed between rs3825016 polymorphism and hyperuricaemia susceptibility only in allelic comparison (C vs. T: OR=1.274, 95% CI 1.101-1.474, p=0.001). CONCLUSIONS: The rs475688 polymorphism is associated with gout susceptibility. The correlation between rs3825016 polymorphism of SLC22A12 and hyperuricaemia susceptibility is possible.

19 Article Association of NLRP3 polymorphisms with susceptibility to primary gouty arthritis in a Chinese Han population. 2018

Zhang, Quan-Bo / Qing, Yu-Feng / He, Yong-Long / Xie, Wen-Guang / Zhou, Jing-Guo. ·Department of Geriatrics of the Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637007, China. · Department of Rheumatology and Immunology of the Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, China. · Institute of Rheumatology of North Sichuan Medical College, Nanchong, Sichuan, 637007, China. · Department of Rheumatology and Immunology of the Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan, 637000, China. jgzhou@nsmc.edu.cn. ·Clin Rheumatol · Pubmed #29214547.

ABSTRACT: The NLRP3-interleukin1β (IL1β) signaling pathway is involved in monosodium urate (MSU)-mediated inflammation. The aim of this present study was to determine whether single nucleotide polymorphisms (SNPs) in the NLRP3 gene are associated with susceptibility to gouty arthritis (GA) and whether these SNPs alter the expression of components of the NLRP3-IL1β signaling pathway. The rs10754558, rs4612666, and rs1539019 SNPs were detected in 583 patients with GA and 459 healthy subjects. NLRP3 and IL1β mRNA levels in peripheral blood mononuclear cells (PBMCs) and serum IL1β levels were measured in different genotype carriers, and correlations between the NLRP3 SNPs and NLRP3 mRNA, IL1β mRNA, and serum IL1β levels were investigated. The GG genotype of NLRP3 rs10754558 was found to be significantly associated with patients with GA compared to the healthy control subjects via multivariate logistic regression analysis (adjusted OR = 2.68, P = 0.006). The CGA haplotypes were independently associated with patients with GA compared to the healthy control subjects (adjusted OR = 1.968, P = 0.02). The levels of NLRP3 mRNA, IL1β mRNA, and serum IL1β in the patients with GA were significantly different among the three genotypes of rs10754558 (all P < 0.01). The GG genotype of rs10754558 and the CGA haplotype of rs4612666-C, rs10754558-G, and rs1539019-A are both independent risk factors for primary GA development. The rs10754558 polymorphism might participate in regulating immune and inflammation responses in patients with GA by influencing the expression of components of the NLRP3 inflammasome. Future multicenter studies aimed at replicating these findings in an independent population as well as functional tests will aid in further defining the role of these SNPs in the development of GA.

20 Article Depression and anxiety correlate with disease-related characteristics and quality of life in Chinese patients with gout: a case-control study. 2018

Fu, Ting / Cao, Haixia / Yin, Rulan / Zhang, Lijuan / Zhang, Qiuxiang / Li, Liren / Feng, Xingmei / Gu, Zhifeng. ·a Research Center of Clinical Medicine , Affiliated Hospital of Nantong University , Nantong, Jiangsu , P.R. China. · b Department of Rheumatology , Affiliated Hospital of Nantong University , Nantong , P.R. China. · c School of Nursing , Nantong University , Nantong, Jiangsu , P.R. China. · d Department of Stomatology , Affiliated Hospital of Nantong University , Nantong, Jiangsu , P.R. China. ·Psychol Health Med · Pubmed #28942667.

ABSTRACT: This study aims to evaluate the prevalence of depression and anxiety and investigate the potential risk factors for depression and anxiety in Chinese gout patients. A self-report survey was administered to 226 gout patients and 232 age- and gender-matched healthy individuals. Patients were asked to complete a set of standardized self-report questionnaires. Univariate and mutiple regression were used to analyze the data. We found 15.0% of gout patients had depression, and 5.3% had anxiety. After adjusted demographic variables, the prevalence of depression was significantly higher than the healthy controls (6.0%). There were significant correlations among education, total pain, disease duration, stage of gout, functional disability, number of tophi, number of flares/last year, presence of tender joints, nephropathy comorbidity, health-related quality of life (HRQoL), and psychological status. Meanwhile, logistic regression analysis identified number of tophi, functional disability, and mental component summary (MCS) as predictors of depression in gout patients. Education and MCS were significantly accounted for anxiety. In summary, the prevalence of depressive symptoms among gout patients was higher than healthy individuals. Education, disability, tophi and HRQoL were important risk factors linked to depression/anxiety in Chinese gout population.

21 Article Association of gout and depression: A systematic review and meta-analysis. 2018

Lin, Song / Zhang, Huaqi / Ma, Aiguo. ·The College of Public Health, Qingdao University, Qingdao, China. ·Int J Geriatr Psychiatry · Pubmed #28921661.

ABSTRACT: OBJECTIVE: Several studies have shown that gout is associated with depression symptoms. In this study, a systematic review and meta-analysis was performed to explore the relationship between gout and depression. METHODS: Published articles were identified through a comprehensive review of PUBMED and EMBASE. Data from studies reporting relative risks, odds ratios, or hazard ratios comparing the risk of depression among participants who had gout versus those without gout were analyzed. A random-effect model was used to calculate pooled odds ratios and 95% confident intervals (CI). RESULTS: Seven studies, which included 411 745 participants, aligned with our inclusion criteria and were included in the meta-analysis. Pooled analysis showed an association between gout and depression, with an odds ratio of 1.19 (95%CI, 1.11, 1.29; I CONCLUSION: Our meta-analysis demonstrates a positive association between gout and depression. Further large-scale prospective cohort studies are needed to investigate the causality between gout and depression.

22 Article [Analysis of serum ferritin and high sensitive C reactive protein in patients with gout]. 2017

Wei, Jingyan / Zhang, Huaqi / Wang, Yan / Li, Changgui / Ma, Aiguo. ·Department of Nutrition and Food Hygiene, College of Public Health, Qingdao University, Qingdao 266023, China. ·Wei Sheng Yan Jiu · Pubmed #29903099.

ABSTRACT: OBJECTIVE: To analyze the relationship between serum ferritin(SF) level and high sensitive C reactive protein( hs-CRP) in men and the risk of gout. METHODS: We chosed 600 male patients diagnosed with gout as gout group, 600 male patients with hyperuricemia were diagnosed as hyperuricemia group, and randomly selected 600 cases of the same period of male health examination as the control group. The detection information of physical examination and related indicators of three groups were collected, such as height, weight, serum ferritin, high sensitive C reactive protein, uric acid( UA), fasting blood glucose( FPG), triglyceride(TG), total cholesterol( TC) and so on. RESULTS: Serum ferritin( SF) higher than that of hyperuricemia group 114. 45 μg/L( P<0. 05)and the control group 76. 02 μg/L( P<0. 05), while the level of hs-CRP in gout patients up to 0. 3 mg/dL, was significantly higher than that 0. 13 mg/dL in hyperuricemia group and 0. 09 mg/dL in control group( all P<0. 05). After adjusting for BMI, TG, TC, FPG and UA five confounding factors, SF was positively correlated with hs-CRP levels in the hyperuricemia group and the gout group, while there was no association between SF and hs-CRP levels in the control group. The multivariate logistic regression analysis showed that SF( ≥ 69. 01 μg/L) had significantly increased risk of HUA, after adjusting for BMI, TG, TC, FPG and UA five confounding factors, the high level of SF( ≥155. 78μg/L) had significantly increased risk of gout, with OR of 2. 678( 95% CI 1. 484-4. 833), and higher levels of hs-CRP( > 0. 9 mg/dL) was also a risk factor of gout, with OR of 3. 104( 95% CI 1. 727-5. 580). However, SF and hs-CRP were not risk factors of hyperuricemia. CONCLUSION: Serum ferritin level and high sensitive C reactive protein levels are significantly elevated in patients with gout. It is revealed that hs-CRP, SF may be involved in the pathogenesis of gout patients.

23 Article Serum connective tissue growth factor is a highly discriminatory biomarker for the diagnosis of rheumatoid arthritis. 2017

Yang, Xinyu / Lin, Ke / Ni, Shanmin / Wang, Jianmin / Tian, Qingqing / Chen, Huaijun / Brown, Matthew A / Zheng, Kaidi / Zhai, Weitao / Sun, Li / Jin, Shengwei / Wang, Jianguang. ·Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou, China. · Department of Biochemistry, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China. · Department of Rheumatology, Jiamusi Central Hospital, Jiamusi, China. · Institute of Health and Biomedical Innovation, Translational Research Institute, Queensland University of Technology, Princess Alexandra Hospital, Brisbane, Australia. · Centre for Precision Medicine, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China. · Department of Orthopaedic Surgery, Shanghai Guanghua Special Hospital for Rheumatoid Arthritis, Shanghai, China. · Department of Immunology and Rheumatology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, China. grassandsun@126.com. · Department of Anesthesia and Critical Care, The Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325035, China. jinshengwei69@163.com. · Department of Biochemistry, School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China. wz_wjg@163.com. ·Arthritis Res Ther · Pubmed #29166915.

ABSTRACT: BACKGROUND: Our previous proteomic study indicated that connective tissue growth factor (CTGF) may be a potential biomarker for rheumatoid arthritis (RA) diagnosis. The aim was to assess the performance of CTGF as a biomarker of RA. METHOD: Serum and synovial fluid CTGF was detected using a direct high sensitivity sandwich ELISA kit. Serum CTGF levels were tested for discriminatory capacity and optimal assay cutoffs determined in a training cohort of 98 cases of RA with 103 healthy controls. The assay performance was then validated in a further cohort of 572 patients (with RA (n = 217), ankylosing spondylitis (n = 92), gout (n = 74), osteoarthritis (n = 52), systemic lupus erythematosus (n = 72), or primary Sjögren's syndrome (pSS) (n = 65)). RESULTS: Significant elevation of synovial fluid CTGF concentration was found in RA patients, demonstrating excellent diagnostic ability to predict RA (area under the curve (AUC) = 0.97). Similar results were found in serum CTGF detection. At the optimal cutoff value 88.66 pg/mL, the sensitivity, specificity, and the AUC was 0.86, 0.92, and 0.92, respectively, in the training cohort. Similar performance was observed in the validation cohort, with sensitivity, specificity, positive likelihood, and negative likelihood of 0.82, 0.91, 5.74, and 0.12, respectively. Stronger discriminatory capacity was seen with the combination of CTGF and anti-citrullinated protein antibody (ACPA) (AUC = 0.96) than with either ACPA or rheumatoid factor (RF) alone (AUC = 0.80 or 0.79, respectively). The discriminatory performance of serum CTGF was consistent across all inflammatory conditions tested (AUC >0.92 in all cases), with the sole exception of pSS. Serum CTGF did not vary with symptom duration or disease activity. CONCLUSIONS: Serum CTGF is a promising diagnostic biomarker for RA, with performance in the current study better than either ACPA or RF.

24 Article Associated factors with functional disability and health-related quality of life in Chinese patients with gout: a case-control study. 2017

Fu, Ting / Cao, Haixia / Yin, Rulan / Zhang, Lijuan / Zhang, Qiuxiang / Li, Liren / Gu, Zhifeng. ·Research Center of Clinical Medicine, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China. · Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China. · School of Nursing, Nantong University, Nantong, Jiangsu, People's Republic of China. · School of Nursing, Nantong University, Nantong, Jiangsu, People's Republic of China. larry017@163.com. · Department of Rheumatology, Affiliated Hospital of Nantong University, Nantong, Jiangsu, People's Republic of China. guzf@ntu.edu.cn. ·BMC Musculoskelet Disord · Pubmed #29100504.

ABSTRACT: BACKGROUND: Gout is a painful, inflammatory disease that may cause decreased function and health-related quality of life (HRQoL). Limited study did not take the influence of gout characteristics and anxiety on HRQoL into consideration and there are no studies associated with functional disability in individuals with gout from China. This study aims to investigate the related factors of functional disability and HRQoL in gout patients recruited from China. METHODS: A total of 226 consecutive gout patients and 232 age- and gender-matched healthy individuals were involved in the study. A series of questionnaires (the Short Form 36 health survey, the Patient Health Questionnaire, the Generalized Anxiety Disorder questionnaire, the 10 cm Visual Analog Scale, and the Health Assessment Questionnaire-Disability Index) were applied. Blood samples were taken to examine the level of serum uric acid. Independent samples t-tests, Chi square tests, U test, Spearman rank correlation, logistic regression modeling, and linear regression were used to analyze the data. RESULTS: After adjusted demographic variables, individuals with gout have poorer HRQoL compared to healthy controls. Univariate tests presented that patients with functional disability had longer disease duration, more frequent flares/last year, more severe total pain, more number of tophi, higher degree of depression and anxiety, with a trend toward diabetes, the treatment of colchicine and corticosteroids use, compared to patients without functional disability. Meanwhile, place of residence, hypertension, DM, disease duration, cardiovascular disease, number of flares/last year, total pain, more number of tophi, presence of tender joints, depression, anxiety, currently using colchicine and corticosteroids were correlated significantly with HRQoL. Additionally, multiple regression analysis identified severe pain, depression, and colchicine use as predictors of functional disability. Cardiovascular disease, total pain, number of flares/last year, presence of tender joints, depression, anxiety, colchicine and corticosteroids use contributed to low HRQoL. CONCLUSIONS: After adjusted demographic variables, gout subjects have poorer HRQoL compared to healthy controls. Chinese gout population experiencing poor HRQoL and functional disability were likely to suffer from gout-related features and psychological problems. The results underscore the need of effective interventions including psychological nursing and appropriate treatment approaches to reduce their functional disability and improve their HRQoL.

25 Article Anti-Gouty Arthritis and Antihyperuricemia Effects of Sunflower 2017

Li, Lanzhou / Teng, Meiyu / Liu, Yange / Qu, Yidi / Zhang, Yuanzhu / Lin, Feng / Wang, Di. ·School of Life Sciences, Jilin University, Changchun 130012, China. · Jilin JiCe Testing Technology Co., LTD, Changchun 130012, China. · Zhuhai College of Jilin University, Jilin University, Zhuhai 519041, China. ·Biomed Res Int · Pubmed #28929115.

ABSTRACT: This study was performed to investigate the therapeutic effects and possible mechanisms of sunflower

Next