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Granuloma Inguinale HELP
Based on 35 articles published since 2010
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These are the 35 published articles about Granuloma Inguinale that originated from Worldwide during 2010-2020.
 
+ Citations + Abstracts
Pages: 1 · 2
1 Guideline [Anorectal STD]. 2016

Janier, M / Dupin, N / Derancourt, C / Caumes, E / Bouscarat, F / Milpied, B / Anonymous3940885. ·Centre clinique et biologique des MST, hôpital Saint-Louis, 42, rue Bichat, 75010 Paris, France. Electronic address: michel.janier@sls.aphp.fr. · Service de dermatologie, hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. · Service de dermatologie, CHU de Fort-de-France, 97261 Fort-de-France, Martinique. · Service des maladies infectieuses et tropicales, hôpital Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75013 Paris, France. · Service de dermatologie, hôpital Bichat Claude-Bernard, 46, rue Henri-Huchard, 75018 Paris, France. · Service de dermatologie, hôpital Saint-André, CHU, 1, rue Jean-Burguet, 33000 Bordeaux, France. ·Ann Dermatol Venereol · Pubmed #27773510.

ABSTRACT: -- No abstract --

2 Guideline [Donovanosis (granuloma inguinale)]. 2016

Caumes, E / Janier, M / Dupin, N / Alcaraz, I / Maatouk, I / Timsit, F-J / Anonymous3930885. ·Service des maladies infectieuses et tropicales, hôpital Pitié-Salpêtrière, 47, boulevard de l'Hôpital, 75013 Paris, France. Electronic address: eric.caumes@psl.aphp.fr. · Centre clinique et biologique des MST, hôpital Saint-Louis, 42, rue Bichat, 75010 Paris, France. · Service de dermatologie, hôpital Cochin, 27, rue du Faubourg-Saint-Jacques, 75014 Paris, France. · Service de dermatologie, centre hospitalier Gustave-Dron, rue du President-Coty, 59208 Tourcoing, France. · Service de dermatologie, Hôtel-Dieu de France, Alfred-Naccache, Achrafieh, Beyrouth, Liban. ·Ann Dermatol Venereol · Pubmed #27773509.

ABSTRACT: -- No abstract --

3 Guideline European guideline for the management of donovanosis, 2010. 2010

O'Farrell, N / Moi, H / Anonymous6210679. ·Ealing Hospital, London, UK. nigel.o'farrell@eht.nhs.uk ·Int J STD AIDS · Pubmed #21097731.

ABSTRACT: Donovanosis is a rare sexually transmitted infection now mainly seen in sporadic cases in Papua New Guinea, South Africa, India, Brazil and Australia. The causative organism is Calymmatobacterium granulomatis though a proposal has been put forward that the organism be reclassified as Klebsiella granulomatis comb. nov. The incubation period is approximately 50 days with genital papules developing into ulcers that increase in size. Four types of lesions are described - ulcerogranulomatous, hypertrophic, necrotic and sclerotic. The diagnosis is usually confirmed by microscopic identification of characteristic Donovan bodies on stained tissue smears. More recently, polymerase chain reaction (PCR) methods have been developed. The recommended treatment is azithromycin 1 g weekly until complete healing is achieved.

4 Review Nonviral Sexually Transmitted Diseases. 2019

Cologne, Kyle G / Hsieh, Christine. ·Division of Colon and Rectal Surgery, Keck School of Medicine at the University of Southern California, Los Angeles, California. ·Clin Colon Rectal Surg · Pubmed #31507345.

ABSTRACT: This article provides a practical overview for the management of nonviral sexually transmitted diseases affecting the perianal and anorectal regions. Clinical manifestations, diagnosis, and treatment of syphilis, gonorrhea, chancroid, donovanosis, and lymphogranuloma venereum are individually addressed.

5 Review Sexually Transmitted Diseases in the Emergency Department. 2019

Pfennig, Camiron L. ·Prisma Health, University of South Carolina School of Medicine Greenville, 701 Grove Road, Greenville, SC 29605, USA. Electronic address: cpfennig@ghs.org. ·Emerg Med Clin North Am · Pubmed #30940365.

ABSTRACT: Sexually transmitted diseases (STDs) continue to be underrecognized leading to devastating health and economic consequences. Emergency clinicians play an important role in diagnosing and managing STDs and in improving health care outcomes for both the patient and their partners. In addition, antibiotic resistance and emerging infections continue to challenge providers in clinical practice. This review focuses on the cause, history, physical examination, diagnostic studies, and treatment strategies for bacterial vaginosis, chlamydia, genital herpes, gonorrhea, human papillomavirus, granuloma inguinale, Lymphogranuloma Venereum, Mycoplasma genitalium, syphilis, and trichomoniasis.

6 Review Other sexually transmitted diseases chancroid and donovanosis. 2016

Copeland, Nathanial K / Decker, Catherine F. · ·Dis Mon · Pubmed #27107782.

ABSTRACT: -- No abstract --

7 Review Sexually Transmitted Infections. 2015

Smith, Lindsay / Angarone, Michael P. ·Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue, Suite 900, Chicago, IL 60611, USA. · Division of Infectious Diseases, Northwestern University Feinberg School of Medicine, 645 North Michigan Avenue, Suite 900, Chicago, IL 60611, USA. Electronic address: m-angarone@northwestern.edu. ·Urol Clin North Am · Pubmed #26475947.

ABSTRACT: Sexually transmitted infections (STIs) remain a significant burden on public health in the United States. Primary prevention counseling with early diagnosis and treatment remain the best methods to decrease the incidence of STIs. Through significant public heath interventions, the incidence of gonorrhea, Chlamydia, and trichomoniasis is decreasing; however, the incidence of primary and secondary syphilis is increasing. Human papilloma virus remains the most common STI, but new vaccinations have the possibility of having a significant impact on this virus's disease potential. This review discusses the most common STIs in the United States, focusing on clinical presentation, diagnosis, and treatment.

8 Review Deep Fungal Infections, Blastomycosis-Like Pyoderma, and Granulomatous Sexually Transmitted Infections. 2015

Guidry, Jacqueline A / Downing, Christopher / Tyring, Stephen K. ·Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA. · Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA. Electronic address: cdowning@ccstexas.com. · Center for Clinical Studies, 1401 Binz, Suite 200, Houston, TX 77004, USA; Department of Dermatology, University of Texas Health Science Center, 6655 Travis, Suite 600, Houston, TX 77003, USA. ·Dermatol Clin · Pubmed #26143434.

ABSTRACT: Granulomatous diseases are caused by multiple infectious and noninfectious causes. Deep fungal infections can present in the skin or extracutaneously, most commonly with lung manifestations. An Azole or amphotericin B is the universal treatment. Blastomycosis-like pyoderma is a clinically similar condition, which is caused by a combination of hypersensitivity and immunosuppression. Successful treatment has been reported with antibiotics and, more recently, the vitamin A analog, acitretin. Granuloma inguinale and lymphogranuloma venereum cause ulcerative genital lesions with a granulomatous appearance on histology. The Centers for Disease Control and Prevention recommens treatment of these genital infections with doxycycline.

9 Review Chancroid, lymphogranuloma venereum, granuloma inguinale, genital herpes simplex infection, and molluscum contagiosum. 2014

Basta-Juzbašić, Aleksandra / Čeović, Romana. ·University Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, HR-10000 Zagreb, Croatia. · University Hospital Center Zagreb, Department of Dermatology and Venereology, School of Medicine University of Zagreb, HR-10000 Zagreb, Croatia. Electronic address: romana.ceovic@zg.htnet.hr. ·Clin Dermatol · Pubmed #24559566.

ABSTRACT: Chancroid, lymphogranuloma venereum, and granuloma inguinale may be considered as tropical venereal diseases. These diseases were a major diagnostic and therapeutic challenge in past centuries. Currently, patients with these bacterial infections that are endemic to the tropics occasionally consult with dermatologists in temperate climates. Due to the increasing frequency of travel to the tropics for tourism and work, as well as the increasing number of immigrants from these areas, it is important for dermatologists practicing in temperate climates to be familiar with the dermatologic manifestations of such infections, to be prepared to diagnose these diseases, and to treat these patients. All three "tropical" infections respond well to prompt and appropriate antimicrobial treatment, although herpes progenitalis still cannot be cured, and the number of people infected keeps growing; moreover, genital herpes can be transmitted by viral shedding before and after the visual signs or symptoms. Acyclovir, valacyclovir, and famciclovir can shorten outbreaks and make them less severe or even stop them from happening. There is currently no etiologic treatment for molluscum contagiosum, and the majority of treatment options are mechanical, causing a certain degree of discomfort. The molluscum contagiosum virus, unlike the other infectious agents mentioned, does not invade the skin.

10 Review Sexually transmitted and anorectal infectious diseases. 2013

Cone, Molly M / Whitlow, Charles B. ·Department of Colon and Rectal Surgery, Vanderbilt University Medical Center, Nashville, TN, USA. ·Gastroenterol Clin North Am · Pubmed #24280405.

ABSTRACT: Sexually transmitted diseases (STDs) are common and they can involve the anus and rectum in both men and women. In this article, the main bacterial and viral STDs that affect the anus and rectum are discussed, including their prevalence, presentation, and treatment.

11 Review Vulvar edema. 2010

Amankwah, Yaa / Haefner, Hope. ·Department of Obstetrics, Gynecology and Newborn Care, The Ottawa Hospital, University of Ottawa, Ontario, Canada. yamankwah@ottawahospital.on.ca ·Dermatol Clin · Pubmed #20883919.

ABSTRACT: Vulvar edema is associated with a variety of conditions. The edema can result from inflammatory conditions, infections, infestations, trauma, pregnancy, tumors and iatrogenic causes. At times, it is difficult to determine the cause of the vulvar edema. Treatment consists of determining the origin of the edema and giving the appropriate therapy for that diagnosis as well as the use of compression and, at times, lymphatic massage.

12 Article The changing epidemiology of genital ulcer disease in South Africa: has donovanosis been eliminated? 2020

Muller, Etienne E / Kularatne, Ranmini. ·STI Section, Centre for HIV & STIs, National Institute for Communicable Diseases, Johannesburg, South Africa etiennem@nicd.ac.za. · STI Section, Centre for HIV & STIs, National Institute for Communicable Diseases, Johannesburg, South Africa. · Department of Clinical Microbiology & Infectious Diseases, Faculty of Health Sciences, University of the Witwatersrand, Johannesburg, South Africa. ·Sex Transm Infect · Pubmed #32075875.

ABSTRACT: OBJECTIVES: We used an in-house molecular assay for the detection of METHODS: Between 2007 and 2018, a total of 974 genital ulcer specimens with no previously identified sexually transmitted (STI) pathogens were selected from STI aetiological surveys conducted in all nine provinces of South Africa. Giemsa-stained ulcer smears from the same participants had previously been routinely analysed for the presence of typical Donovan bodies within large mononuclear cells. A RESULTS: The CONCLUSIONS: This is the first study to assess

13 Article [Sexually Transmitted Infections in the Tropics]. 2018

Bendick, C. ·Department of Dermatology, Preah Kossamak-Hospital, BP 1006, Phnom Penh, Kambodscha. cambodia.derma@gmail.com. ·Hautarzt · Pubmed #30324430.

ABSTRACT: Sexually transmitted infections (STI) are common all over the world and the incidence of chlamydia, gonorrhea, syphilis and trichomoniasis alone is estimated at 500 million/year. Of these infections 75% occur in tropical countries in Latin America, sub-Saharan Africa and South as well as Southeast Asia. The bacterial infections chancroid, lymphogranuloma venereum (LGV) and granuloma inguinale (GI, Donovanosis) are termed tropical STI. They occur mainly in tropical countries, i. e. regions situated between the equator and the northern and southern 23.5° latitudes, regions which are characterized by hot humid climates as well as poverty and underdevelopment. These three diseases are primarily associated with ulcerations of the skin, thus their presence represents an increased risk for transmission of HIV and other STI. As with all STI, to minimize the risk of tropical infections it is essential to avoid hazardous sexual practices and to use condoms.

14 Article 2018 UK national guideline for the management of donovanosis. 2018

O'Farrell, Nigel / Hoosen, Anwar / Kingston, Margaret. ·1 London North West Healthcare University NHS Trust, Ealing Hospital, London, UK. · 2 Medical Microbiology, University of Free State, Bloemfontein, South Africa. · 3 The Northern Sexual Health, Contraception and HIV Service, The Hathersage Centre, Manchester, UK. ·Int J STD AIDS · Pubmed #29743002.

ABSTRACT: The objective of this guideline is to provide guidance for the diagnosis and management of donovanosis, a now rare sexually transmitted infection. This guidance is primarily for professionals working in UK Sexual Health services (although others may find it useful) and refers to the management of individuals presenting with possible symptoms of donovanosis who are over the age of 16. An updated literature review since the last Clinical Effectiveness Group (CEG) guideline produced for this condition in 2011 has shown few new developments. Most reports in the literature relate to cases of unusual presentations of the condition.

15 Article Donovanosis With Bowen Disease. 2017

Narang, Tarun / Manhas, Ashwini / Kumar, Bhushan. ·Department of Dermatology, Venereology & Leprology, Post Graduate Institute of Medical Education and Research, Chandigarh, India; narangtarun@yahoo.co.in. · Department of Microbiology, Gian Sagar Medical College and Hospital, Ram Nagar, Banur, Patiala, India. · Silver Oaks Multispecialty Hospital, Mohali, Punjab, India. ·Skinmed · Pubmed #28270316.

ABSTRACT: A 45-year-old farmer presented with ulcers and plaques over his scrotum for the past 4 to 5 years. The condition started as a small lesion on the shaft of the penis, which improved with treatment; however, after 2 to 3 months, papulonodular lesions developed on the scrotum, which increased in size and subsequently broke down to form ulcers. He denied drug abuse but had a history of multiple unprotected sexual exposures. He was prescribed oral antibiotics, which improved the lesions, but he failed to take the antibiotics for more than a week. He also used powders, lotions, and salves (exact nature not known), which did not help and sometimes even burned the skin. After stopping the medicine, he developed new lesions that followed a similar course. Examination revealed nontender ulcers on the scrotum with raised, rolled-out margins and pale red, granulation tissue that bled on touch (Figure 1). In addition, there were nodules with a pinkish red granular surface and scaly erythematous plaques on the scrotum. Regional lymph nodes were not enlarged.

16 Article Donovanosis and squamous cell carcinoma: The relationship conundrum! 2017

Arora, Amanjot K / Kumaran, Muthu S / Narang, Tarun / Saikia, Uma N / Handa, Sanjeev. ·1 Department of Dermatology, Venereology and Leprology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. · 2 Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India. ·Int J STD AIDS · Pubmed #27535727.

ABSTRACT: Donovanosis is a rare, chronic and indolent sexually transmitted infection caused by Klebsiella granulomatis. The ulcers in donovanosis rarely undergo malignant transformation, which is usually seen in longstanding ulcers. We present a case of a 32-year-old male who presented with a two-month history of rapidly progressive, large, foul-smelling ulcers over the groin, distal penile shaft and scrotum. Crushed tissue smears from ulcers revealed basophilic intracellular and extracellular Donovan bodies. Fine needle aspiration cytology from inguinal lymph nodes and biopsy from the ulcers revealed well-differentiated squamous cell carcinoma. The current case aims to alert clinicians that donovanosis is a rare but possible cause of cutaneous malignancy. Nonetheless, the pathogenesis of malignant transformation in donovanosis needs further research.

17 Article Granuloma inguinale in a 51-year-old man. 2016

Ornelas, Jennifer / Kiuru, Maija / Konia, Thomas / Larsen, Larissa. ·School of Medicine, UC Davis. lnlarsen@ucdavis.edu. ·Dermatol Online J · Pubmed #27617463.

ABSTRACT: Granuloma inguinale, or Donovanosis, is a rare, sexually transmitted ulcerative disease primarily affecting the genital area. In this report, we present a case of a 50-year-old man that was diagnosed with granuloma inguinale after a 2-month history of a penile ulcer. Histological analysis demonstrated the presence of Donovan bodies within macrophages, confirming the diagnosis. He was subsequently treated with trimethoprim/sulfamethoxazole with improvement in the ulcer. This case serves as a reminder to clinicians that although granuloma inguinale is rarely encountered in the US, it should still be suspected in patients with non-healing penile ulcers.

18 Article [A case of donovanosis acquired in France]. 2016

Okhremchuk, I / Marmottant, E / Abed, S / Nguyen, A-T / Fournier, B / Boye, T / Morand, J-J. ·Service d'anatomie et cytologie pathologiques, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon, France; Service de dermatologie et de vénérologie, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon, France. Electronic address: ilonaokh@hotmail.fr. · Service de dermatologie et de vénérologie, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon, France. · Service d'anatomie et cytologie pathologiques, HIA Sainte-Anne, 2, boulevard Sainte-Anne, 83800 Toulon, France. ·Ann Dermatol Venereol · Pubmed #27174716.

ABSTRACT: INTRODUCTION: Donovanosis (granuloma inguinale) is a bacterial infection caused by Klebsiella granulomatis that occurs mainly in the genital area and is primarily sexually transmitted; it is seen predominantly in the tropics. Herein, we report a case of the disease contracted in metropolitan France. PATIENTS AND METHODS: A 47-year-old man presented with painless ulceration of the glans, present for one month, with progressive extension; there was no history of any recent trip abroad. Skin biopsy with Whartin-Starry and Giemsa staining revealed Donovan bodies in the cytoplasm of macrophages. Based on these findings, further questioning of the patient revealed unprotected sexual contact two months earlier in France. Treatment was initiated with azithromycin 1g on the first day followed by 500mg per day for three weeks. The clinical outcome was spectacular, with almost complete regression of the ulcer at 7 days. DISCUSSION: This case demonstrates that donovanosis can occur in metropolitan France.

19 Article 2016 European guideline on donovanosis. 2016

O'Farrell, Nigel / Moi, Harald. ·Pasteur Suite, Ealing Hospital, London, UK nigel.o'farrell@nhs.net. · Olafia Clinic, Oslo University Hospital, Institute of Medicine, University of Oslo, Norway. ·Int J STD AIDS · Pubmed #26882914.

ABSTRACT: Donovanosis is a rare sexually transmitted infection now mainly seen in sporadic cases in Papua New Guinea, South Africa, India, Brazil and Australia. The causative organism is Calymmatobacterium granulomatis, though a proposal has been put forward that the organism be reclassified as Klebsiella granulomatis comb nov The incubation period is approximately 50 days with genital papules developing into ulcers that increase in size. Four types of lesions are described - ulcerogranulomatous, hypertrophic, necrotic and sclerotic. The diagnosis is usually confirmed by microscopic identification of characteristic Donovan bodies on stained tissue smears. More recently, polymerase chain reaction methods have been developed. The recommended treatment is azithromycin 1 g weekly until complete healing is achieved.

20 Article Non-healing genital herpes mimicking donovanosis in an immunocompetent man. 2016

Gupta, Vishal / Khute, Prakash / Patel, Anjali / Gupta, Somesh. ·Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India omeshgupta@hotmail.com. · Department of Dermatology and Venereology, All India Institute of Medical Sciences, New Delhi, India. · University of Bristol, Bristol, UK. ·Int J STD AIDS · Pubmed #25614521.

ABSTRACT: Although atypical presentations of herpetic infection in immunocompetent individuals are common, they very rarely have the extensive, chronic and verrucous appearances seen in the immunocompromised host. We report a case of genital herpes manifesting as painless chronic non-healing genital ulcers with exuberant granulation tissue in an immunocompetent man. Owing to this morphology, the ulcers were initially mistaken for donovanosis. To the best of our knowledge, such a presentation of genital herpes in an immunocompetent individual has not been described previously.

21 Article National Notifiable Diseases Surveillance System surveillance report: Sexually transmissible infections in Aboriginal and Torres Strait Islander people. 2015

Bright, Amy. ·Office of Health Protection, Australian Government Department of Health, Canberra, Australian Capital Territory. ·Commun Dis Intell Q Rep · Pubmed #26779731.

ABSTRACT: -- No abstract --

22 Article Donovanosis causing lymphadenitis, mastoiditis, and meningitis in a child. 2015

Ahmed, Nadia / Pillay, Ashendri / Lawler, Melissa / Bobat, Raziya / Archary, Moherndran. ·Department of Genitourinary Medicine, Mortimer Market Centre, London, UK. Electronic address: nadia.ahmed2@nhs.net. · Department of Paediatric Infectious Diseases, King Edward VIII Hospital, KwaZulu-Natal, South Africa. · Department of Paediatrics, University of KwaZulu-Natal, South Africa. ·Lancet · Pubmed #26122163.

ABSTRACT: -- No abstract --

23 Article Squamous cell carcinoma complicating donovanosis not a thing of the past! 2014

Sethi, Sumit / Sarkar, Rashmi / Garg, Vijay / Agarwal, Shipra. ·Department of Dermatology and Venereology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India. · Department of Dermatology and Venereology, Maulana Azad Medical College and Associated Hospitals, New Delhi, India rashmisarkar@gmail.com. · Deparment of Pathology, Maulana Azad Medical College and Associated Hospital, New Delhi, India. ·Int J STD AIDS · Pubmed #24554002.

ABSTRACT: Donovanosis causes granulomatous ulceration of genitalia and neighbouring sites with little tendency to heal spontaneously. It is uncommonly seen nowadays in sexually transmitted infection clinics of north India. The present case is reported for its scarcity and to make clinicians aware of this disease which may rarely accompany carcinoma.

24 Article [Lymphogranuloma venereum: new serovariant L2b and old "groove sign"]. 2013

de Lavaissière, M / Nougué, J. ·CH Montauban, médecine Interne, pathologies infectieuse et tropicales, 100, rue Léon Cladel, 82000 Montauban, France. delavaissierem@yahoo.fr ·Bull Soc Pathol Exot · Pubmed #23749408.

ABSTRACT: An ongoing lymphogranuloma venereum (LGV) outbreak has been reported in several European countries since 2003, related to a new variant L2b. This serovar appears to affect men who have sex with men (MSM), most of them being co-infected with the Human Immunodeficiency Virus (HIV). The secondary stage of LGV may involve lymph nodes and the inguinal form has sometimes been described on each side of the inguinal ligament thus named the "groove sign". We report the case of LGV serovariant L2b acquired by an heterosexual intercourse in an HIV seronegative patient who presented with an inguinal lymph node and a "groove sign". This is an uncommon but suggestive sign of LGV and we suggest that the clinical presentation of L2b LGV might not be so different than other variants and than the 20th century authors' description. Such a new Chlamydia trachomatis variant may circulate in other populations than MSM in Europe and clinical awareness must prevail.

25 Article Infantile donovanosis presenting as external auditory canal polyps: a diagnostic trap. 2012

Ramdial, Pratistadevi K / Sing, Yetish / Ramburan, Amsha / Naidu, Tesuven K / Samuel, Elizabeth Y / Bagratee, Jayanthilall S / Calonje, Eduardo. ·Department of Anatomical Pathology, School of Laboratory Medicine & Medical Sciences, University of KwaZulu-Natal, Durban, KwaZulu-Natal, South Africa †National Health Laboratory Service, Durban, KwaZulu-Natal, South Africa. ramdial@ukzn.ac.za ·Am J Dermatopathol · Pubmed #23169417.

ABSTRACT: Two infants, 6 months and 4 months of age, presented with bilateral or unilateral external auditory canal polyps and otorrhea, respectively. Additional findings on examination included otitis media and mastoiditis. Tympanic membrane perforation was noted in one patient and a postauricular abscess in the other. Incisional biopsies of the polyps and abscess were reported as nonspecific mixed inflammation and abscess wall, respectively. There was a limited response to an empirical 5-day course of trimethoprim sulfamethoxazole. The children were referred to the academic hospital, and excision of the polyps and biopsies of the middle ear, mastoid, and postauricular abscess was undertaken. All the biopsies demonstrated donovanosis. Reappraisal of the initial incisional biopsies also confirmed donovanosis. Trimethoprim sulfamethoxazole was administered to both patients for 3 weeks, with resolution of the lesions. Subsequent investigations confirmed genital tract donovanosis, human immunodeficiency virus seropositivity, acquired immunodeficiency syndrome, and pulmonary tuberculosis in both mothers. Heightened awareness of the occurrence of donovanosis at unusual sites and improved recognition of the histomorphological features of the disease, especially in small and superficial biopsies, are pivotal not only for its correct diagnosis in extragenital cutaneous and extracutaneous locations but also for timely and adequate therapy and an improved infant and maternal outcome.

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